The Egg Whisperer Show – Details, episodes & analysis

Read the full show notes here: https://www.draimee.org/boosting-egg-quality-what-we-know-about-nad-and-fertility-with-dr-mark-ratner

I'm honored to be joined by Dr. Mark Ratner, Chief Science Officer at Theralogix. We're diving deep into the science of NAD+ - what it is, why it matters for fertility, and how it might help improve egg quality and outcomes for those pursuing IVF or egg freezing. Dr. Ratner, a board certified urologist, brings a wealth of expertise in nutritional supplements and reproductive health, and I've been looking forward to sharing this conversation with you.

Throughout our interview, we explore the fascinating roles of NAD+ and sirtuins in ovarian health, discuss the latest research (from mice to humans!), and break down what these findings could mean for anyone hoping to preserve or boost their fertility. We also touch on practical strategies, from supplements to lifestyle changes, and address common questions about safety, effectiveness, and the future of this exciting area of reproductive science.

In this episode, we cover:

• What NAD+ is and why it's crucial for egg health and fertility
• The role of sirtuins as "master regulators" in our cells and their connection to ovarian reserve
• How age-related declines in NAD+ and sirtuins impact egg quality
• Insights from animal and human studies on NAD+ supplementation and fertility outcomes
• The difference between NAD+ supplements and precursors like nicotinamide riboside
• Dietary and lifestyle approaches to boosting NAD+ (and why caloric restriction isn't for everyone)
• The growing awareness among fertility specialists and what's next for research in this field

Resources

Get OvaNAD+ from Theralogix at their website (use the code EGG for a 15% discount)

Join The IVF Class
Find Dr. Aimee's Fertility Essentials & Supplements   Do you have questions about IVF?
Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, November 17, 2025 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!
Subscribe to the newsletter to get updates

Did you know that nearly all embryos show some level of mosaicism, even in successful pregnancies? In this conversation with Meaghan Doyle, a Licensed Certified Genetic Counselor specializing in fertility genetics and the founder of DNAide Genetic Counseling, we're discussing the latest findings on PGT-A testing and what it means for embryo selection and fertility treatment: and this is fascinating!

Meaghan joins me to discuss a fascinating new article titled "New PGT-A Test Shows that Nearly All Blastocysts and Fetal Tissue are Mosaic." We'll break down what this means for fertility treatment, embryo selection, and how patients can use this information to make the best decisions for their family-building journey.

In this episode, we cover:

• What PGT-A testing does and how its sensitivity has evolved
• What mosaicism is and why nearly all embryos exhibit it
• How new research is changing the way we interpret mosaic results
• What these findings mean for embryo selection and transfer decisions
• How fertility patients can advocate for themselves and make informed choices

Resources
Find Meaghan Doyle's DNAide Genetic Counseling website here
Follow Meaghan on Instagram
Join The IVF Class
Find Dr. Aimee's Fertility Essentials & Supplements

Do you have questions about IVF?
Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, November 17, 2025 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!
Subscribe to the newsletter to get updates

In this episode, I'm honored to welcome Dr. Ray Dorsey, a renowned neurologist, researcher, and author of the New York Times bestseller, The Parkinson's Plan. Together, we dive into the critical topic of Parkinson's Disease, now the fastest growing neurological disorder in the world, and explore how environmental toxins (rather than aging or genetics), are fueling its rise. Dr. Dorsey shares his expertise on how exposures, even as early as in utero, can increase the risk of Parkinson's and other serious conditions, and offers practical steps families can take to protect themselves and future generations.

Throughout our conversation, we discuss the broader themes of environmental health, fertility, and advocacy. We explore the science behind how early-life exposures can plant the seeds for neurodegenerative diseases, the importance of shifting our understanding from genetics to environment, and the actionable ways we can reduce risk. Dr. Dorsey also introduces the "Parkinson's 25" - a set of practical recommendations for families, and shares inspiring stories of advocacy and change.

In this episode, we cover:
💙Why Parkinson's Disease is rising and the role of environmental toxins
💙The impact of early-life and in utero exposures on long-term neurological health
💙The difference between genetic and environmental risk factors for Parkinson's
💙How pesticides, air pollution, and chemicals like trichloroethylene affect fertility and brain health
💙The "Parkinson's 25" steps for reducing risk and protecting your family
💙Advocacy success stories, including the Healthy Schools Act and organic golf courses
💙Practical tips for improving indoor air quality and minimizing everyday exposures

Resources:
The Parkinson's Plan book: https://amzn.to/46V7BZu
The Parkinson's Plan website: pdplan.org
Contact Dr. Dorsey: info@pdplan.org
Healthy Schools Act (California): https://www.cdpr.ca.gov/cac-letter/written-policy-clarifying-state-and-county-roles-in-enforcing-provisions-of-the-healthy-schools-act-assembly-bill-2260/
Countdown by Shanna Swan (on fertility and environmental toxins): 
https://amzn.to/4nSniGR
National Plan to End Parkinson's Act: https://www.ninds.nih.gov/current-research/trans-agency-activities/national-plan-end-parkinsons

Do you have questions about IVF?
Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, November 17, 2025 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.
Follow on Apple Podcasts Follow on Spotify Subscribe to my YouTube channel for more fertility tips!
Subscribe to the newsletter to get updates
Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

AMH hormone is a useful Fertility Screening test used to guide people about how many eggs they have left, but the results can be confusing. Find out everything you need to know about this "Always Meandering Hormone," and how it impacts infertility.

Would you like to learn about IVF?
Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, July 14, 2025 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.
Subscribe to my YouTube channel for more fertility tips!

Join Egg Whisperer School
Follow the podcast
Subscribe to the newsletter to get updates
Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Recently, Elizabeth shared a question on AskTheEggWhisperer.com. She is 41, and she and her husband are carriers of a recessive disorder that results in severe physical and mental disability. Here's what she says, "I'm 41 AMH 0.95. We had a little girl naturally when I was. 40, but she didn't survive. We have a 25% chance of recurrence to screen for the disorder.
We did our first round of IVF and we got results back today out of seven eggs, five fertilized, three made it to blast. We have one normal that is not affected. There was another normal blast, but it was affected, and there was one with abnormal chromosomes. We're so happy to have a good one to use.
We might want two children though. I have two more rounds covered by insurance, but they can't be used for embryo banking. Should I wait until after a healthy pregnancy with our good one to do IVF again? Or should we do another round now?"

You can tune in to hear my answer, and listen to the answers to other listener questions.

Listen on Dr. Aimee's website
  Subscribe to my YouTube channel for more fertility tips!
  Join Egg Whisperer School
Checkout the podcast
Subscribe to the newsletter to get updates
Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Recently, Tracy shared a question on AskTheEggWhisperer.com. She is 29, and her husband is 39.
Here's what she says, "I have hypothalamic amenorrhea. I've had two egg retrievals. The first egg retrieval, three fertilized after seven retrieved, one blast tested abnormally. The second retrieval, we added an Omnitrope and dexamethazone during stimulation. ICSI and calcium solution to the eggs. Five retrieved, one fertilize, one blast, and it was normal. I eat very well, I take supplements, I meditate, and I am doing acupuncture.  Any ideas on why have such poor fertilization? Do you think I have poor quality eggs, or is that the protocol that's hurting them? Should we be testing my husband's sperm further? What would you do for my next cycle?
Thank you for being such a guiding light."

You can tune in to hear my answer, and listen to the answers to other listener questions.

Listen on Dr. Aimee's website
  Subscribe to my YouTube channel for more fertility tips!
  Join Egg Whisperer School
Checkout the podcast
Subscribe to the newsletter to get updates
Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

In this live Fertility Expert Q and A , I'm joined by Dr. Andrea Vidali. I had the honor of interviewing him about Pregmune, a platform for patients to receive a Reproductive Immunology work-up with him. We dove into the 6 categories that are part of a reproductive immunology work-up: HLA testing, NK activity, Systemic Inflammation, Thrombophilia, Regulatory T-cell, and Autoimmunity. It was so fascinating to learn from the best today. I hope you will listen in!

Listen on Dr. Aimee's website
Subscribe to my YouTube channel for more fertility tips!
  Join Egg Whisperer School
Subscribe to the newsletter to get updates
  Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Today, on the Egg Whisperer Show podcast, I'm excited to be joined by Dr. Andrea Vidali. He is a world renowned endometriosis specialist, surgeon, miscarriage specialist and reproductive immunologist. Dr. Vidali is the founder and CEO of Pregmune, a healthcare information company that leverages his research in the fields of IVF and its relation to miscarriage and Immunology.

I'm delighted to have him join us to talk about Pregmune and the role immunological factors play in fertility. In today's interview, we are going to be talking about what fertility patients need to know about immunological factors, how immunological factors may present themselves when diagnosed with "unexplained infertility," 6 important factors that may impact your ability to conceive, and how to get tested in order to see if any immunological factors may be involved when having difficulty conceiving.

Listen on Dr. Aimee's website
Subscribe to my YouTube channel for more fertility tips!
  Join Egg Whisperer School
Subscribe to the newsletter to get updates
  Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Most fertility treatment hinges on the strategic use of drugs to help the body be as fertile as possible. My goal is to give each of my patients a personalized fertility plan with custom calendars of what to do, which drug to take, and when.

Today on the podcast, I'm walking through fertility calendars (keeping things confidential, of course) and talking about the drugs I commonly use to give my patients the best chance at fertility success. 

Read the full show notes on Dr. Aimee's website

Subscribe to my YouTube channel for more fertility tips!

Join Egg Whisperer School
Checkout the podcast
Subscribe to the newsletter to get updates

Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Recently, Rita sent a question in to Ask the Egg Whisperer. She is 30 and lives in Boston. Here's what she has to say, "I recently found out I have silent endometriosis, and had surgery for it. I'm now experiencing worse and more aggressive endometriosis. I've switched fertility doctors to one who specializes in excision surgery and fertility, and his recommendations was to do one cycle of fast-track IVF and bank as many embryos as possible.
What is fast track IVF, opposed to regular IVF?
He did not put me on an "endo friendly" protocol. Do you get fewer eggs with an endo friendly protocol?
My dream is to be a mom of five. My AMH is 4, FSA is 7.
I've been taking CoQ10, 0 fish oil, vitamin D, NAC, and I just started melatonin.
Is there anything else you can recommend?"

You can tune in to hear the answer to Rita's question, along with other listener questions.

Have IVF questions? Join The IVF Class at The Egg Whisperer School

Follow on Apple Podcasts Follow on Spotify   Subscribe to my YouTube channel for more fertility tips!
Subscribe to the newsletter to get updates
Submit your question at AskTheEggWhisperer.com
  Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.