ICU Ed and Todd-Cast – Details, episodes & analysis

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Episode 46! In this episode we talk about thrombolytic windows in acute ischemic stroke from TIMELESS published by Albers et al published in the New England Journal of Medicine and then we talk about ANDROMEDA shock and serial lactates published by Hernandez et al!

TIMELESS (pubmed): https://pubmed.ncbi.nlm.nih.gov/38329148/
TIMELESS (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2310392
ANDROMEDA-Shock (pubmed):https://pubmed.ncbi.nlm.nih.gov/30772908/
ANDROMEDA-Shock (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2724361

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 45! In this episode we talk about sepsis bundles and the 1-BED trial by Fruend et al and discuss the stress ulcer prophylaxis guidelines just published in SCCM!

1-BED (pubmed): https://pubmed.ncbi.nlm.nih.gov/38913098/
SUP Guidelines: https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/SCCM-ASHP-Guideline-Prevention-of-UGIB

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 36! In this episode we talk about tranexamic acid in GI bleeds. We flip the script a little bit and talk about our OLD article first, HALT-IT or "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis: A randomized controlled trial" published in Lancet in 2020. This sets the stage for our new trial "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis" published in Kumar et al in Hepatology (a new journal for us!)

HALT-IT: https://pubmed.ncbi.nlm.nih.gov/32563378/
TXA and cirrhosis: https://pubmed.ncbi.nlm.nih.gov/38441903/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 35! In this episode we talk about extubation practices with "Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial" published in Intensive Care Medicine by Hernandez et al. We then talk about an observation study by Zarrabian et al published in the Blue Journal "Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions".

SPEED UP: https://pubmed.ncbi.nlm.nih.gov/38353714/
Extubation on Pressors: https://pubmed.ncbi.nlm.nih.gov/35107416/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 34! In this episode we talk about oxygen targets! Specifically we go over the two oxygen target analyses that were published simultaneously with ISICEM. We spend most of our time with HOT-COVID published by Nielson et al and then dip a little into individualized treatment effects of oxygen targets published by Buell et al - both published in JAMA March 2024. The latter is a complex topic and we hit some of the high points but please reach out to us if you want a more in depth discussion!

HOT-COVID: https://pubmed.ncbi.nlm.nih.gov/38501214/
Individualized Treatment Effects: https://pubmed.ncbi.nlm.nih.gov/38501205/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 33! In this episode we are excited to be joined by Eddy Fan and Whitney Gannon, two extraordinary ECMO researchers to talk about VENT-AVOID or " Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease" published March 2024 by Duggal et al in the ATS Blue Journal.

VENT-AVOID: https://pubmed.ncbi.nlm.nih.gov/38261630/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 32! We got a lot of feedback on our last episode so we decided to address it in a full episode! A lot of listeners asked us about vasopressors specifically vasopressin and angiotensin-2 so we talk about VASST, VANISH, and ATHOS-3. It is a full episode but a good one!

VASST: https://pubmed.ncbi.nlm.nih.gov/18305265/
VANISH: https://pubmed.ncbi.nlm.nih.gov/27483065/
ATHOS-3: https://pubmed.ncbi.nlm.nih.gov/28528561/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 31! This episode we talk first about invasive vs non-invasive blood pressures from an observational paper titled "Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults" published in journal of Intensive Care Medicine by Haber et al and then for our old trial we further the discussion of blood pressure by talking about the 65 trial!

Non-invasive vs invasive blood pressure: https://pubmed.ncbi.nlm.nih.gov/38215002/
65 Trial: https://pubmed.ncbi.nlm.nih.gov/32049269/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 30! This episode is a little different. We recap the SCCM conference first. THEN we go into PROPHY-VAP or "Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury" published January 2024 by Professor Dahyot-Fizelier in Lancet Respiratory Medicine. Then we dive into our long neglected mailbag to review listener questions about MINT, intubation timing, ACORN, and all the steroids in ARDS talk

PROPHY-VAP: https://pubmed.ncbi.nlm.nih.gov/38262428/
SCCM Steroid guidelines: https://pubmed.ncbi.nlm.nih.gov/38240492/
Counter-Point should we use steroids in ARDS: https://pubmed.ncbi.nlm.nih.gov/33422201/
sRAGE in NIV and HFNC: https://pubmed.ncbi.nlm.nih.gov/38250011/
Anaerobes in Aspiration: https://pubmed.ncbi.nlm.nih.gov/37250794/
Anaerobes in Gut: https://pubmed.ncbi.nlm.nih.gov/36229047/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 29! We stray a little bit from our new and old article structure to talk about two recently published but slightly different ARDS recommendations from ATS and ESCIM. We compare and contrast them and give our takes on the data and evidence.

Thanks to everyone who emails in and gives feedback, we will do our mail bag next episode!

ATS Guidelines: https://pubmed.ncbi.nlm.nih.gov/38032683/
ESICM guidelines: https://pubmed.ncbi.nlm.nih.gov/37326646/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!