This Week in Virology – Details, episodes & analysis

TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• MicrobeTV Discord Server
• Gaza baby has polio (Times Israel)
• Monkeypox virus clade Ib in Thailand (CIDRAP)
• Updated COVID-19 vaccines (FDA)
• Effectiveness of Ebola virus vaccine (Lancet Inf Dis)
• Measles cases in Georgia, Oregon (CIDRAP)
• Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell)
• Receptor shifts govern submergence of encephalitis arbovirus (Nature)
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• Letters read on TWiV 1145
• Timestamps by Jolene. Thanks!

Kathy – Googlegangers and AWWW clip
Rich – RP FLIP (floating instrument platform)
Alan – Big labs are bad for careers
Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.

Become a patron of TWiV!

• Fauci recovering at home from West Nile Virus infection (STAT News)
• Gaza: poliovirus RNA in sewage water (GPEI)
• Bombs and polio…..cease fire, Oh my!  (Guardian)
• The variant type 2 poliovirus in Gaza  (United Nations: The Question of Palestine)
• 25 years polio free?  (Facebook)
• 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN)
• More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard)
• Sloth fever……Oropouche virus (USA Today)
• Oropouche virus disease import into US (MMWR)
• Gabon’s first case of mpox (CIDRAP)
• Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs)
• What about vaccines? (Bavarian Nordic)
• LC16 replicating smallpox vaccine (WHO)
• Historical smallpox vaccination against mpox clade II (Eurosurveillance)
• FDA approves Emergent Bio’s smallpox vaccine for mpox (Reuters)
• Mpox: epidemiology and vaccinology (Emerging Infectious Disease)
• Tecovirimat for MPOX? (STOMP)
• UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO)
• WHO preparedness plan prepares to lunch (CIDRAP)
• Working blindly against new mpox isolate (Reuters)
• CDC monkey pox response: TRANSMISSION ? (CDC Newsroom)
• The mpox (Africa CDC: Centers for Disease Control and Prevention)
• Evidence for mpox respiratory transmission(LANCET Microbe)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response)
• Great, more SARS-CoV-2 testing! (CIDRAP)
• EUA for updated Novavax COVID-19 vaccine (FDA)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• IDSA suggests new preventive COVID-19 agent (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Breakthrough from pemivibart/permgarda (bioRxiv)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry)
• Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine)
• Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
• Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature)
• Letters read on TWiV 1144
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• MicrobeTV Discord Server
• What’s going on with measles? (J Virol)
• Poliovirus in Gaza (Science)
• Sanitation concerns in Gaza (AP)
• Community vaccine beliefs (PLoS One)
• 14 year old dies of Nipah in India (Hindustan Times)
• Selection of nirmatrelvir resistance mutants (Sci Adv)
• CCHFV monoclonal antibodies (Cell Rep)
• CCHFV vaccine (TWiV 565)
• Prometheus Project (TWiV 578)
• TWiV at USAMRIID (TWiV 1015)
• Letters read on TWiV 1135
• Timestamps by Jolene. Thanks!

Angela – Animal research is not always king
Brianne – Why the US has more tornadoes than any other country
Dickson – Earth’s core has slowed so much it’s moving backward
Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove
Vincent – Seventh patient ‘cured’ of HIV: why scientists are excited

Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• Wastewater surveillance data as a complement to tracking incidence of influenza A and RSV (CDC)
• Chatbot-delivered online intervention to promote seasonal influenza vaccination (JAMA)
• Temporal assessment of disparities in California COVID-19 mortality by industry (AOE)
• CDC/HICPAC’s plan to weaken guidance for health care respiratory protection and infection control (NNU)
• Modelling the impact of a high-uptake bivalent booster scenario on COVID-19 burden (The Lancet)
• Can high COVID-19 vaccination rates in adults help protect unvaccinated children? (ES)
• Paxlovid use and hospitalizations or death in previously uninfected high-risk population with COVID-19 (JID)
• Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID)
• Vaccination after developing long COVID (IJID)
• Contribute to our Floating Doctors fundraiser at PWB
• Letters read on TWiV 1046
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.

• Norton Zinder, 83 (Reuters)
• Jenner's cowpox vaccine paper (Bartleby, Gutenberg)
• Norovirus VLP vaccine (NEJM)
• Plant-grown H5N1 VLP vaccine (Reuters, PLoS One)
• Plant-grown norovirus VLP
• Hexavalent pediatric vaccine
• TWiV on Facebook
• Letters read on TWiV 170

Michael and the TWiV team review epidemiology basics, including fatality ratios.

• Michael's blog and podcast
• Epidemiology literature critique (PowerPoint)
• Seven mistakes in epidemiology (ETE)
• Snow cholera map
• TWiV on Facebook
• Letters read on TWiV 169

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

• Vectored HIV immunoprophylaxis (Nature)
• Vectored immunoprophylaxis - the Movie (YouTube)
• Adeno-associated virus (Wikipedia)
• In vitro evolution of H5N1 towards human receptor specificity (Virology)
• Endogenous viral genes non-essential in chicken (Nature)
• Rates of HIV transmission per coital act (J Inf Dis)
• TWiV on Facebook
• Letters read on TWiV 168

The complete TWiVome deconstructs the movie Contagion.

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.

• Niemann-Pick C1 is entry factor for HCV (Nature Med)
• Ebola virus entry requires Niemann-Pick C1 (Nature one, two)
• Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens)
• An exit strategy for measles virus (Science)
• On this day in history
• TWiV on Facebook
• Letters read on TWiV 166

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.