Performance Around The Clock – Details, episodes & analysis

Performance Around the Clock episode 20 comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the pleasure to talk with Dr. Christoph Scheiermann who studies the role of circadian rhythms in immune response and how this impacts health and disease.  In particular, he’s known for his research on the recruitment and localization of leukocytes which is under circadian control.  This process plays a crucial role in immune response which can be leveraged to improve cancer immunotherapy and vaccination efficacy.  Learn more about his impactful research in this episode. Thanks for listening.

Guest:

Dr. Christoph Scheiermann

Full Professor

Department of Pathology and Immunology

Centre Medical Universitaire (CMU)

X (formerly Twitter): @ScheiermannLab

https://twitter.com/ScheiermannLab

Lab webpage:

http://scheiermannlab.de/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi.  Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior.  His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadianClock gene.  In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.

Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:

The Honma Prize in Biological Rhythms Research

NSF Presidential Young Investigator Award

Searle Scholars Award

Bristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia University

Fellow of the American Academy of Arts and Sciences

Member of the National Academy of Sciences

Member of the National Academy of Medicine

Gruber Neuroscience Prize at the Society for Neuroscience

Guest:

Dr. Joseph Takahashi

Chair of the Department of Neuroscience at UT Southwestern Medical Center

Loyd B. Sands Distinguished Chair in Neuroscience

X (formerly Twitter): @CircadianClocks

https://twitter.com/circadianclocks

UT Southwestern profile:

https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.html

Lab webpage:

https://labs.utsouthwestern.edu/takahashi-lab

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In this special, 10th episode of the Performance Around the Clock podcast, we have the honor of speaking with Professor Greg Lemke of the Salk Institute. We discuss his distinguished scientific career from the early beginnings to the discovery of TAM receptor tyrosine kinases. Enjoy.

Guest:

Dr. Greg Lemke

Françoise Gilot-Salk Chair and professor in the Molecular Neurobiology Laboratory

Salk Institute for Biological Studies

Laboratory: https://www.lemkelab.org/

Salk page: https://www.salk.edu/scientist/greg-lemke/

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 9 of Performance Around the Clock, we are delighted to talk to cardiologist, Dr. Elizabeth Sage Epstein again. Dr. Epstein and Dr. Panda discuss the role of cholesterol in cardiovascular disease risk. The conversation covers topics such as the absorption of fat and cholesterol in the body, the impact of LDL particles on plaque formation in coronary arteries, and the use of advanced cardiology techniques, such as NMR LipoProfile and calcium scoring, to assess cardiovascular health. Dr. Epstein emphasizes the importance of understanding cholesterol levels and how they contribute to the risk of cardiovascular disease, and also highlights the potential for lifestyle changes to reverse plaque development.

Guest:

Dr. Elizabeth Sage Epstein, Scripps Health, Integrative Cardiology Fellow

X (formerly Twitter): @lizziesageMD

https://twitter.com/lizziesageMD

Author:

A Beautiful Heart Cookbook: Heart-Healthy Recipes for a Long, Happy Life

https://www.amazon.com/Beautiful-Heart-Cookbook-Heart-healthy-Recipes/dp/1982234164

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/satchinpanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 8 of the Performance Around the Clock podcast, Dr. Satchin Panda has an enlightening conversation with Dr. Elizabeth Sage Epstein, a cardiologist and author. They discuss the importance of the heart and impact on overall health, preventive measures for chronic diseases, the cardiovascular system and the importance of cardiac health in young, active individuals.

Guest:

Dr. Elizabeth Sage Epstein, Scripps Health, Integrative Cardiology Fellow

X (formerly Twitter): @lizziesageMD

https://twitter.com/lizziesageMD

Author:

A Beautiful Heart Cookbook: Heart-Healthy Recipes for a Long, Happy Life

https://www.amazon.com/Beautiful-Heart-Cookbook-Heart-healthy-Recipes/dp/1982234164

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 7 of the Performance Around the Clock podcast, Dr. Panda talks with Dr. Michael Lam who is a pulmonologist and assistant professor at the UCSD in the Department of Medicine and in the Division of Pulmonary, Critical Care, and Sleep Medicine. They explore the science of the immune system and link with circadian rhythms, delving into the impact of sleep, light, and even meal timing on the body's immune system. They also discuss challenges faced in the ICU and strategies for improving recovery.

Guest:

Dr. Michael T Lam, (MD/PhD)

Assistant Professor

Division of Pulmonary, Critical Care, and Sleep Medicine

Department of Medicine

University of California, San Diego

https://profiles.ucsd.edu/michael.lam

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 6 of Performance Around the Clock, host Professor Satchin Panda interviews Dr. Horacio de la Iglesia, a sleep and circadian expert from the University of Washington. We discuss how circadian rhythms affect nearly every aspect of human physiology and behavior, from hormone levels to sleep-wake cycles. Dr. De la Iglesia shares insights from his research on ancestral populations like the Toba who live without electricity, as well as modern teenagers and the impact of light exposure, sleep deprivation, and delayed school start times. We discuss the need to educate the public and medical community about circadian health. The episode highlights how circadian biology can inform public policy and simple lifestyle changes we can make, like increasing natural daylight exposure, to improve health.

Guest:

Dr. Horacio de la Iglesia

Professor, University of Washington

X (formerly Twitter): @horacioIglesia

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 5 of the PATC podcast, ophthalmology expert Dr. Kajuha Shubota discusses key research on how light affects vision and overall health with host Dr. Satchin Panda. He explains how lack of time outdoors and violet light exposure is increasing myopia rates in children, and eyeglasses may exacerbate the issue. He shares how dry eye is linked to stress and lifestyle factors. For presbyopia, he discusses potential drug and lens replacement solutions to improve near vision. Throughout, Dr. Shubota emphasizes how the eye offers valuable insights into aging and diseases like Alzheimer’s, as improving ocular blood flow with light may boost brain function. He remains optimistic that innovations in glasses design and lighting can profoundly improve vision and wellbeing across all life stages.

Guest:

Dr. Kazuo Tsubota

Professor, Department of Ophthalmology, Graduate School of Medicine, Keio University

Profile: http://tsubota.ne.jp/en/profile/profile.html

Lab page: https://tsubota-lab.com/en/

Host:

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 4 of the podcast, Dr. Tinh-Hai Collet, a physician and principal investigator at Geneva University Hospital, discusses with Dr. Satchin Panda his experience combining lifestyle interventions like meal timing and circadian rhythms with medicine to manage chronic conditions in patients. We discuss Dr. Collet's research on time-restricted eating, including a 6-month randomized controlled trial in Switzerland. We also discuss implementing lifestyle changes like intermittent fasting under medical supervision, potential side effects, impacts on conditions like diabetes and hypertension, and the importance of spreading circadian health knowledge among more physicians. Overall, this conversation highlights the potential for optimizing meal timing and circadian rhythms, alongside medication when needed, to improve health outcomes.

Guest:

Dr. Tinh-Hai Collet

Diabetes Center of the Geneva University Hospital (HUG)

https://www.unige.ch/medecine/diabetescentre/membres/dr-tinh-hai-collet

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 3 of this podcast, sleep and circadian rhythm expert, professor Frank Scheer discusses how our internal body clocks regulate physiology and behaviors in a 24-hour cycle. He explains how measures like dim light melatonin onset and cortisol rhythms provide insights into circadian timing. The discussion covers how factors like light exposure, meal timing, and sleep impact circadian rhythms and health. Dr. Scheer shares research on misaligning behaviors and physiology through social jet lag, night shifts, and mistimed eating. He suggests strategies like optimizing meal timing and light exposure to realign circadian rhythms. Overall, the discussion highlights how adjusting daily behaviors can improve circadian alignment, metabolism, mood, and wellbeing. Enjoy.

Guest:

Dr. Frank Scheer

Professor of Medicine, Brigham and Women's Hospital

Division of Sleep and Circadian Disorders at Harvard

X (formerly Twitter): @harvardsleepmed

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/