Dr. Mike T Nelson gets geeky with the latest research and scientific findings in the fitness world. Visit www.flexdiet.com to get Flex Diet Certified and www.miketnelson.com for more geeky goodness.
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Données mises à jour le 30/09/2026
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Is Zone 2 Overrated? HIIT, VO2 Max & Metabolic Flexibility with Dr. Martin Gibala — #405
Épisode 406
lundi 28 septembre 2026 • Durée 01:02:56
Dr. Martin Gibala is a Professor of Kinesiology at McMaster University and one of the world's leading researchers on high-intensity interval training.
Can short bursts of hard cardio outperform hours of Zone 2 for the average person? Exercise physiologist Dr. Martin Gibala explains how HIIT can improve VO2 max and metabolic flexibility, why elite athletes' 80/20 split may not fit a time-strapped schedule, and how to judge vigorous effort without chasing a perfect heart-rate zone.
Expect to learn how to scale HIIT for beginners, what RPE and the talk test reveal about vigorous effort, when short sprints differ from VO2 max intervals, why elite athletes’ 80/20 approach may not fit your schedule, how Zone 2 definitions can mislead, and what metabolic flexibility and mitochondrial capacity really mean—and much more.
Episode 404: Whole-Body MRI, CT Scans, and What Imaging Can Tell You — Matthew Paul Clemons, MD
Épisode 405
lundi 21 septembre 2026 • Durée 01:21:45
Matthew Paul Clemons, MD, is a diagnostic radiologist specializing in nuclear medicine and body imaging. He is Head of Nuclear Medicine at Radiology Partners Houston and a rectal and prostate cancer specialist.
Whole-body MRI promises a detailed look under the hood—but what can a quick screening scan actually see, miss, and send you chasing? Dr. Paul Clemons explains why a whole-body MRI is a limited study, how incidental findings can lead to further tests, and why standard screening remains the better choice for most people.
Expect to learn how MRI creates images and why scan protocols take time, why open MRI systems can have important image-quality limits, how PET/MRI adds functional information, why CT and MRI can be complementary rather than redundant, how radiation and implanted devices factor into decisions, why spine findings do not always match symptoms, when conservative care deserves consideration, and where DEXA versus MRI can be useful for tracking body-composition trends.
Episode Timestamps: 1:50 Whole-body MRI and preventive screening 2:52 How MRI works: magnets, noise, and safety 7:05 Open MRI, magnet strength, and image quality 9:05 MRI sequences, scan time, and diagnostic protocols 11:47 Why whole-body MRI is a limited screen 12:46 Incidental findings and downstream testing13:57 High-risk screening, rare genetic conditions, and lung limits17:53 Sensitivity, specificity, and standard screening24:15 PET/MRI and where whole-body imaging has a clinical role27:05 Why MRI and PET/CT systems are expensive to install31:59 MRI safety, implants, and pacemakers36:36 CT versus MRI: why one scan can lead to another38:52 Whole-body CT, radiation, and its limits43:47 Back-pain scans: why an image may not explain symptoms51:44 Physical therapy, surgery, and warning signs58:46 Evaluating evidence for peptides, stem cells, and biologics1:05:47 Choosing an orthopedic surgeon for athletic goals1:15:24 DEXA versus MRI for body-composition trends
AI Disclosure, Deepfakes & the Death of Expertise — Dean Guedo & Jeb Stuart Johnston — #404
Épisode 404
lundi 14 septembre 2026 • Durée 01:19:51
Dean Guedo is an Edmonton, Alberta-based online nutrition coach and strength/nutrition professional with roughly a decade in fitness, athletics and strength sports, and Jeb Stuart Johnston is a National Board Certified Health & Wellness Coach and the Charleston, SC-based founder of Food on the Mind, specializing in emotional eating and food obsession.
Dean and Jeb join Dr. Mike T Nelson for their yearly AI check-in, getting into whether creators should disclose AI use and why deepfaked video is a very different beast than AI-assisted writing. The conversation ranges into dead internet theory, why so much hard-won fitness expertise never made it onto the internet at all, and why demanding physical skills may become more valuable, not less, as AI accelerates.
Expect to learn whether creators should disclose their AI use and why deepfaked video is a fundamentally different risk category than AI-assisted writing, why LLM writing may have already "peaked" and regresses toward the average, why fitness's hard-won oral tradition (Charlie Francis, Louie Simmons, old forums) never made it onto the internet at all, why oral defense of your own thinking may be the most AI-proof skill you can build, and why demanding physical skills could become more valuable — not less — as AI accelerates, and much more.
Newsletter: Tangential, Inconsequential, Existential and Experiential (Substack)
Episodes you'll enjoy next:
Episode 136 — Flex Diet, Phys Flex, Metabolism and Nutrition Research for Compound Performance (Jeb and Dean interview Dr. Mike T Nelson):
Building a Fitness Empire: Business Lessons, Zone 2 & Recovery Trends with Don Saladino — #403
Épisode 403
mardi 8 septembre 2026 • Durée 01:20:32
Don Saladino is a New York-based coach and health entrepreneur who has trained A-list clients like Ryan Reynolds, Hugh Jackman, and Blake Lively since founding Drive495 in 2005.
Don Saladino has spent nearly three decades training A-list stars like Ryan Reynolds and Hugh Jackman — and in this episode, he shares the single business lesson he wishes he’d learned sooner. He and Dr. Mike also dig into why Don closed his $2M-overhead NYC gym, how tracking respiratory rate reshaped his approach to Zone 2 training, and the sobering personal loss that changed how he views performance enhancers.
Expect to learn why Don stopped over-certifying and started looking at what’s leaking in his business, how he built 17 years of trust with a client like Ryan Reynolds, the real financial toll of running a NYC gym (think $1M rent and $2M overhead), what tracking respiratory rate taught him about Zone 2 training volume, his honest take on performance enhancers at 49 (natural), and the personal loss that reshaped how he views unsupervised PED use, and much more.
#402 — VO2 Max, Zone 2 Training & the Psychology of Human Performance — Ben Skutnik: Listen here
#397 — How Elite Bodybuilders Think About Problem-Solving, Business and Nutrition with Coach Cliff Wilson: Listen here
Episode Timestamps:
2:26 — #1 Business Lesson: Stop Over-Certifying, Start Looking at What’s Leaking
VO2 Max, Zone 2 Training & the Psychology of Human Performance — Ben Skutnik — #402
Épisode 402
lundi 31 août 2026 • Durée 01:36:43
Dr. Ben Skutnik, PhD, CSCS*D, NSCA-CPT*D, is an Assistant Professor of Kinesiology and Human Performance Lab Director at Butler University and Head of Nutrition Coaching at Power Athlete.
Dr. Ben Skutnik joins the show to separate fact from fad in aerobic training, debunking zone 2 hype and explaining why VO2 max matters but isn't everything.
Expect to learn why reading scientific literature is its own skill, how uncontrolled variables quietly derail hypertrophy and menstrual-cycle training research, why treating people as fragile backfires, why anecdote in human performance often outruns the research, how "closing the loop" with clients beats chasing mechanisms, what the Norwegian 4x4 method gets right (and what most zone 2 research gets wrong about training zones), and how to actually build VO2 max with the critical power model, and much more.
#400 — Build Aerobic Fitness Before Mitochondrial Peptides: AMPK, VO2 Max & Recovery — Dr. Dwayne Jackson: Listen here
#374 — Zone 2 Cardio: What the Science Really Says (Pros, Cons & Better Options) with Kristi Storoschuk: Listen here
Episode Timestamps:
1:46 — Why Ben was recommended for this conversation on cardiovascular and aerobic programming
Psychedelics, Neuroplasticity and the Military-to-Spiritual Journey with Rick Alexander — #401
Épisode 401
lundi 24 août 2026 • Durée 01:14:57
Rick Alexander is a depth-psychological counselor, psychedelic practitioner, and interfaith spiritual care provider currently completing his Ph.D. in Mythology/Depth Psychology and a former Naval Special Operations combat medic.
Rick was a Special Operations combat medic until a single psychedelic experience shattered his worldview and sent him back to school to study psychedelic spiritual care. He and Dr. Mike dig into neuroplasticity windows, why “good trip/bad trip” is the wrong question, and what may really be happening in DMT space.
Expect to learn how a rough teenage salvia trip and a later psilocybin experience redirected Rick's entire career, what life is really like as a Special Operations Combat Medic supporting SEALs and Green Berets, why military training narrows emotional range and makes civilian re-entry so hard, how integration (not the trip itself) determines whether a psychedelic experience heals or destabilizes you, what the "third wave" of psychedelic science gets right that the DSM's "hallucinogen" label gets wrong, whether neuroplastic windows could help athletes learn skills faster, and what a brutal 5-MeO-DMT experience taught Rick about his own running form and breathing.
#47 — Tools to Down-Regulate in Response to Stress (an earlier conversation with Rick Alexander): Listen here
#194 — The Pros and Cons of Psychedelic Compounds with Psychedelic Researcher Rebekah Senanayake: Listen here
Episode Timestamps:
Build Aerobic Fitness Before Mitochondrial Peptides: AMPK, VO2 Max & Recovery — Dr. Dwayne Jackson — #400
Épisode 400
lundi 17 août 2026 • Durée 01:19:09
Dr. Dwayne Jackson is a health specialist, medical educator, scientist, and entrepreneur with a PhD in neurovascular physiology.
Mitochondrial peptides may be promising, but they cannot replace the aerobic base that makes their effects measurable. Dr. Dwayne Jackson explains AMPK and mitochondrial signaling, what MOTS-c and SS-31 can and cannot tell us, and why fitness data, training, and recovery come before any experimental compound.
Expect to learn how aerobic fitness supports strength and Strongman training, why lactate clearance and conditioning can become the rate limiter, what AMPK and mTOR signal, how kidney disease changed Dwayne’s perspective on aerobic capacity, where the evidence for MOTS-c and SS-31 is limited, how to design a more useful N-of-1 experiment, and why training, nutrition, recovery, COAs, and third-party testing come before experimental compounds.
01:53 — Mitochondrial peptides and the aerobic-training foundation
03:19 — Peptides as training amplifiers, not replacements
Episode 399: Urolithin A, Mitochondrial Health, and Nutrition for Pro Athletes — Dr. Emily Werner
Épisode 399
lundi 10 août 2026 • Durée 01:09:37
Emily Werner, PhD, RD, CSSD, IFNCP is Team Dietitian for the Philadelphia 76ers (NBA) and Philadelphia Flyers (NHL), and Nutrition Affairs Sport Lead at Timeline.
Dr. Emily joins Dr. Mike to unpack postbiotics, urolithin A, and why mitochondrial health matters for pro athletes and everyday people alike, digging into the real research behind Timeline's Mitopure and why chasing $200K gadgets rarely beats getting the fundamentals right.
Expect to learn what a postbiotic actually is and how urolithin A differs from other supplements, why old-school and new-school sports dietitians disagree on peptides and supplement fads, how chronic undereating quietly undermines performance in women's sports, what the current human performance research on urolithin A actually shows, how Mitopure is dosed and why urolithin A can't be reliably food-sourced, and why product quality and manufacturing integrity matter more than marketing claims, and much more.
#377 — Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr: Listen here
#382 — Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety) with Dr. Darren Candow: Listen here
Getting Back to Nutrition Basics: Gut Health, Micronutrients & Training with Zach Moore
Épisode 398
mardi 4 août 2026 • Durée 01:16:23
Zach Moore is a nutrition and exercise coach based in southern Indiana, coaching clients online and in person.
Zach cuts through the noise of complicated programming and diet protocols to get back to what actually works — minimalist strength training, honest macro-setting, and paying attention to gut health and micronutrient status before chasing anything fancier.
Expect to learn how to build serious strength with far less training volume than you think, why chasing perfect programming conditions is often a waste of energy, how Zach sets carbohydrate and macro targets for real-world clients, when (and when not) to bother with micronutrient or gut testing, and why micronutrients matter even on restrictive or elimination diets, and much more.
27:06 Individualizing & dialing in training volume
How elite bodybuilders think about problem-solving, business and nutrition with Coach Cliff Wilson
Épisode 397
lundi 27 juillet 2026 • Durée 01:15:20
Cliff Wilson is a physique coach with over 16 years of experience working with bodybuilders and physique athletes of every level, including 24 world champions and the current natural bodybuilding world champion.
Getting better doesn’t make hard things feel easier—it makes you capable of doing more. Cliff Wilson explains the mental skills behind elite physiques, why context beats internet absolutes, and how great coaches turn research, experience, and failure into better decisions.
Expect to learn why impulse control makes up 20–50% of physique coaching, why you have to learn to dribble before you try to dunk, why practitioners and social media commentators are not the same thing, why getting fitter never makes a true max effort feel easier, how context (not absolutes) explains wildly different carb intakes between world-class physique athletes, why most advanced bodybuilders eventually land back on a bro split, and what separates “collectors” of credentials from coaches who can actually integrate and apply what they know—and much more.
2:21 Welcome & introductions
6:09 What is a postbiotic? Pre-, pro-, and postbiotics explained
7:09 Urolithin A: the postbiotic behind Mitopure
8:19 How Emily started consulting for Timeline
10:11 Old-school vs. new-school sports dietitians on supplements
13:53 Peptides, anecdata, and why athletes ignore the data
20:05 The hardest lesson: letting go when clients won't listen
21:15 Money, ego, and athletes chasing $200K wellness gadgets
24:53 Chronic undereating in women's sports
30:48 Nutrition's real job: keeping athletes available to play
33:19 Inside Mitopure: Timeline's flagship urolithin A product
35:06 Mitochondria, mitophagy, and why they matter as we age
38:16 Diet, fasting, and exercise as natural mitophagy triggers
43:36 What the performance research on urolithin A actually shows
53:19 Aging, aerobic capacity, and Emily's 101-year-old grandma
55:40 Mitopure dosing: how much urolithin A and when to take it
57:14 Why urolithin A can't be food-sourced (and can't be faked)
1:03:19 Why product quality and integrity matter in supplements
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