Clinician, researcher, and gut-geek Dr. Michael Ruscio DC covers the ever-changing world of functional health science. From debunking trends to research deep dives to practical takeaways, Dr. Ruscio DC Radio is health science made digestible.
These [podcasts] are educational and informational only and are not medical, chiropractic, psychological, or other professional advice of any kind. They do not create or constitute any professional relationship between us and you. Always consult your licensed healthcare providers and never disregard or delay obtaining medical advice based on information in our [podcast]. Please review our full terms of use and disclaimers posted on our Website at https://drruscio.com/privacy-policy.
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Données mises à jour le 11/10/2026
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1028 - The Histamine Treatment That Helped These Patients Get Their Lives Back
Épisode 590
dimanche 27 septembre 2026 • Durée 19:13
Could calming overactive mast cells help with chronic fatigue, brain fog, and food reactivity? Dr. Ruscio explores remarkable improvements reported in a Johns Hopkins case series using cromolyn sodium—a mast cell stabilizer developed from the plant compound khellin. Learn how it works in the gut, dosing and safety considerations, and how it may help highly reactive patients tolerate treatment for underlying triggers.
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
*Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.
1027 - What Happens When You Drink Kefir Every Day?
Épisode 589
mardi 15 septembre 2026 • Durée 17:46
What happens when you drink kefir every day? In this video, Dr. Ruscio breaks down findings from 70+ clinical trials on this traditional fermented drink, including its potential effects on gut health, digestion, inflammation, metabolic health, and even brain function. He also covers how much kefir to drink, whether homemade or store-bought is better, and what to look for on the label.
Not all probiotics are created equal, and even a good probiotic may not work if you're using the wrong formula, dose, or duration.
In this episode, Dr. Ruscio breaks down how to choose a high-quality probiotic, what GMP and third-party testing actually tell you, how long probiotics typically need to work, the most evidence-supported formula types and doses, and what to do if you're sensitive or don't respond.
And if you have any questions or topics you would like covered in the future, let me know in the comments!
👇Read these next 👇
📌 Timestamps 🎧 Audio Episode & Featured Studies Follow Me
1025 - Why Antifungal Treatment Fails (And What to Do Instead)
Épisode 587
dimanche 16 août 2026 • Durée 01:09:34
In this episode, Dr. Ruscio and Dr. Scott Spiridigliozzi break down why mold and fungal treatments often fail—and what may improve the odds of success. They discuss how to get clearer on the diagnosis, why herbal therapies may not be enough for some patients, the importance of reaching therapeutic antifungal levels, why underdosing can backfire, and how targeting the right tissues may help prevent relapse. They also share insights from their own experiences with chronic fungal illness and how those lessons are shaping their evolving treatment approach.
📌Timestamps 🎧Audio Episode & Featured Studies Follow Me
1024 - How to Save Your Gallbladder and Avoid Surgery
Épisode 586
dimanche 9 août 2026 • Durée 23:39
Gallbladder removal may not always be the only option. In this video, Dr. Scott Spiridigliozzi explains how SIBO and gut dysbiosis may contribute to gallstones, sludge, and poor gallbladder function. He also shares two patient cases and the gut-focused protocol used to resolve their symptoms and help them avoid surgery.
Could hidden fungus or mold exposure be driving recurring gut symptoms? In this episode, Dr. Scott Spiridigliozzi interviews Dr. Pejman Katiraei about a novel "backdoor" mechanism through which inhaled fungal toxins may reach the gut through the bloodstream, disrupt the microbiome, increase intestinal permeability, and contribute to persistent symptoms such as bloating, food reactions, fatigue, brain fog, and anxiety.
They also discuss how to identify possible fungal or environmental triggers and the practical steps that may help restore gut health and reduce symptoms.
Parasites are an often-overlooked factor in chronic gut symptoms, food intolerance, histamine-type reactions, fatigue, and cases where patients feel stuck despite addressing SIBO, Candida, or other common gut imbalances. In this episode, Dr. Ruscio, Dr. Jake Vonfeldt, and Dr. Scott Spiridigliozzi discuss common parasites like Giardia, Cryptosporidium, Blastocystis, pinworms, and helminths, why standard testing can miss them, and how clinical history can help determine when parasites deserve closer consideration. They also share both natural and pharmaceutical parasite protocols, along with practical guidance on when each approach may be appropriate.
📌Timestamps 🎧Audio Episode & Featured Studies Follow Me
1021 - The Surprising Gut + Energy Benefits of NAC (N-Acetylcysteine)
Épisode 583
dimanche 31 mai 2026 • Durée 35:47
In this episode, Dr. Ruscio breaks down the surprising gut and systemic benefits of NAC (N-acetylcysteine), including how it may help break down biofilms, support SIBO and H. pylori treatment, improve gut lining repair, boost nutrient absorption, and support glutathione, mitochondria, and brain health. You'll also learn when sustained-release NAC may be useful, how to dose NAC properly, and what side effects or cautions to keep in mind.
📌 Timestamps 🎧 Audio Episode & Featured Studies Follow Me
1020 - This New Histamine Treatment Helped 89% of Patients
Épisode 582
dimanche 24 mai 2026 • Durée 29:04
New research suggests that low-dose peptide therapy may help calm histamine-driven inflammation and mast cell activation in people with stubborn symptoms like food reactions, brain fog, fatigue, flushing, itching, hives, bloating, and digestive distress. In this episode, Dr. Ruscio explains how the gut, histamine, and mast cells are connected, what the latest human research shows, and why this approach may help some patients who haven't fully responded to diets, supplements, or other natural therapies.
Dr. Ruscio and Dr. Scott discuss a clinical framework for fungus, Candida, and mold as potential drivers of persistent gut, sinus, brain fog, fatigue, and inflammatory symptoms. They cover key diagnostic clues, sinus involvement, blood mold antibodies, sinus CT, limitations of urine mycotoxin testing, and treatment options including diet, probiotics, herbals, biofilm support, sinus therapies, and prescription antifungals.
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/
📉Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis: https://pubmed.ncbi.nlm.nih.gov/9378812/
📉Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients: https://pubmed.ncbi.nlm.nih.gov/17048974/
📉Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox: https://pubmed.ncbi.nlm.nih.gov/33132781/
Facebook - https://www.facebook.com/DrRuscio
Instagram - https://www.instagram.com/drruscio/
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉 Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemical indexes and bile composition in patients with cholecystolithiasis: https://pubmed.ncbi.nlm.nih.gov/36353477/
📉 Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemical indexes and bile composition in patients with cholecystolithiasis: https://pubmed.ncbi.nlm.nih.gov/36353477/
📉 Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth: https://pubmed.ncbi.nlm.nih.gov/23574267/
📉 Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia:
📉 A positive correlation between autonomic nervous system function and endoscopic disease severity in chronic rhinosinusitis: https://pubmed.ncbi.nlm.nih.gov/40988571/
Facebook - https://www.facebook.com/DrRuscio
Instagram - https://www.instagram.com/drruscio/
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/
📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/
📉Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection: https://pubmed.ncbi.nlm.nih.gov/20922415/
📉Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: https://pubmed.ncbi.nlm.nih.gov/20038852/
📉Impact of vitamin A on selected gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico: https://pubmed.ncbi.nlm.nih.gov/17041847/
📉Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis:
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Supplementary endoscopy video reproduced from: Baumgartner M, Lang M, Holley H, et al. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology (2021). Available on PubMed Central. Licensed under CC BY 4.0.
📉 Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: https://pubmed.ncbi.nlm.nih.gov/38299014/
📉 The role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men: https://pubmed.ncbi.nlm.nih.gov/33405232/
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉 Improvement of Chronic Spontaneous Urticaria After Glucagon-Like Peptide 1 Receptor Agonist Therapy: Report of Two Cases: https://pubmed.ncbi.nlm.nih.gov/41535531/
📉 Unintended Benefit of GLP-1 Treatment for Obesity: Resolution of Chronic Systemic Mastocytosis Symptoms:
📉 International Society for Mast Cell Activation Syndromes:https://ismcas.org/
Facebook - https://www.facebook.com/DrRuscio
Instagram - https://www.instagram.com/drruscio/
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
📉 Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/
📉 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth: https://pubmed.ncbi.nlm.nih.gov/23574267/
📉 Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox: https://pubmed.ncbi.nlm.nih.gov/33132781/
📉 Efficacy of generic forms of itraconazole capsule in treating subjects with chronic pulmonary aspergillosis:
DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
*Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.
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