Unseen Upside: Investments Beyond Their Returns – Details, episodes & analysis

Step into the world of advanced robotics, where AI is transforming how we work, move, and live. 

Discover how surgical robots, autonomous vehicles, and AI-driven exoskeletons are advancing healthcare, streamlining operations, and restoring independence for individuals. Hear from innovators at Xeno Dynamics, leading investors, and a family whose journey with multiple sclerosis (MS) inspired a foundation dedicated to advancing exoskeleton rehabilitation, opening doors to greater autonomy and inclusion worldwide.

Guests include:

• Maram Fakhouri, Vice Chair and Co-Founder of STF5 Care Foundation
• Zhe Liang, Chairman of Xeno Dynamics
• Lior Susan, Founder and Managing Partner of Eclipse Ventures
• Judy Zhang, Head of China Client Business and Partner at Cambridge Associates

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.

Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

Travel to a Vermont dairy farm to see how AI is reshaping agriculture.

Learn how data-driven tools are making farming more sustainable and productive, and how companies like Inari Seeds are engineering crops for a changing climate. This episode uncovers the future of food—where technology, tradition, and environmental stewardship meet.

Guests include:

• Lucas Mann, Co-Founder and Managing Partner of Acre Venture Partners
• Catherine Feuillet, Chief Scientific Officer at Inari
• Richard Nelson, Farmer at Nelson Dairy Farm

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.

Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

How will evolving digital technologies impact healthcare delivery, patient experience, and access to care?

According to new venture-backed companies, they can advance health equity, democratize access, and empower individuals to take control of their health journey. Alongside industry pioneers and investors, we explore digital health advancements such as telemedicine, remote monitoring, and data-driven diagnostics that are all working to improve healthcare efficiencies.

Join us as we uncover the potential of these technologies to improve healthcare outcomes for all.

Guests include:

• Lynne Chou O'Keefe, Founder & Managing Partner at Define Ventures
• Siva Namasivayam, CEO & Co-Founder at Cohere Health
• Chavon Sutton, Senior Investment Director in the Sustainable & Impact Investing Research Group at Cambridge Associates

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.

Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Join us in Kotzebue, Alaska to explore the issue of rural healthcare and the inequities faced by these communities.

We shine a light on innovative solutions aimed at improving rural healthcare delivery, like a program called Siamit that’s connecting cutting-edge medicine from Massachusetts General Hospital (MGH) and Harvard Medical School to the tribal regions of Alaska. We also look at the role of venture capital in driving advancements that promote access to healthcare for those living in rural parts of the country.

Guests include:

• Lucas Trout, Lecturer on Global Health and Social Medicine at Harvard Medical School
• Susan Rawlings Molina, Co-Founder and CEO at GroundGame Health
• Alyssa Jaffee, Partner at 7wireVentures

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.

Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Prescription drug prices in the United States are 2.78 times higher than in other developed countries, but why?

We untangle the barriers surrounding drug affordability and find out why accessing life-saving medications is costly to so many. Joined by experts, advocates, and one Cystic Fibrosis patient relying on expensive medication to live, we examine the complex factors contributing to the high costs of drugs, from research and development to pricing strategies and supply chain dynamics. We also investigate potential solutions to improve access and affordability without compromising on drug innovation.

Guests include:

• Peter Kolchinsky, Founder and Managing Partner at RA Capital
• Gunnar Esiason, Head of Patient Engagement at RAVen (RA Ventures)
• Dean Dimizas, Partner in the Private Client Practice at Cambridge Associates

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.

Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Join us as we head to the Bronx to examine the critical intersection of housing and health and the innovative solutions that are aiming to address the affordable housing crisis in major cities like New York and LA. Through conversations with non-profit leaders and impact investors, we dive into how affordable housing impacts public health and health equity, highlighting the investment strategies and community partnerships that are moving the needle. We also discuss the challenges of housing insecurity and the disproportionate effects on marginalized communities, recognizing affordable housing is a critical determinant of community health. 

Guests include:

• Margaret Anadu, Senior Partner at The Vistria Group
• Tim Ortez, Vice President & Chief Financial Officer at Weingart Foundation
• Jasmine Richards, Head of Diverse Manager Research at Cambridge Associates

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

How does venture capital contribute to advancing health equity and public health? Find out on season five of Unseen Upside, premiering Tuesday, October 8.

This season, we dive into how today's investment decisions are shaping tomorrow's innovations in critical areas such as affordable housing, maternal health, drug pricing, and more. Join us for engaging conversations with investors and entrepreneurs as we uncover the profound impact of venture capital on our lives on a grand scale.

Powered by the global network of Cambridge Associates, join us to explore healthcare investments beyond their returns.

Listen now to Unseen Upside. 

While we’re busy pulling together stories for the fifth season of Unseen Upside, we thought you might be curious about what it is that Cambridge Associates actually does. In a nutshell, we have the privilege of partnering with some of the world’s top institutional investors—like nonprofits, universities, hospitals, pension plans, and even private families—and we try to help them reach their investment goals.

Recently, we had a conversation with four of our non-profit clients from institutions with assets ranging from $200 million to $850 million to understand why they chose to outsource day-to-day portfolio decisions so they could focus on bigger picture strategy for their organizations. Their stories offer insight into how we collaborate with clients so they can do even more for the communities they serve. 

Don’t forget to check back this fall for the latest season of Unseen Upside: Investments Beyond Their Returns.

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Artificial intelligence is transforming healthcare, unleashing new investment opportunities. From cancer screening to drug discovery, AI promises to augment clinical decision-making and improve care. 

We’ll explore the surging ecosystem of medical AI innovations, from the emerging tech landscape to practical deployment. But what are the challenges facing real-world implementation? Which applications show the most promise? 

Join us as we investigate how artificial intelligence can change healthcare for the better while examining what it will take to do it well. 

Guests include:

• Bob Nelsen, Co-Founder and Managing Director at Arch Venture Partners
• Daphne Koller, Founder and CEO at insitro
• David Baker, Ph.D., 2024 Nobel Prize in Chemistry Laureate, Director at the Institute for Protein Design and Professor of Biochemistry at University of Washington
• Theresa Hajer, Partner and Managing Director of Venture Capital Research at Cambridge Associates

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Autoimmune diseases like lupus impact over 5 million patients globally, but treatment options remain limited. Now, decoding the once mysterious "dark genome" could bring new therapies. Over 90% of our DNA was once considered "junk"—but we’ve learned this dark matter regulates gene expression and human disease. This episode takes you to the pioneers who are unlocking the dark genome's potential to correct root causes of complex conditions like lupus. We'll chat with those illuminating this uncharted territory and developing novel approaches. 

Guests include:

• Rosana Kapeller, M.D., Ph.D., Co-Founder, President, & CEO at Rome Therapeutics
• Steve Kafka, General Partner at S32
• Keri Mastrogiacomo, mother of a Lupus patient
• Katherine Cavanagh, Associate Investment Director at Cambridge Associates 

This episode has named a Winner by the International Women’s Podcast Awards for their “A Moment of Visionary Leadership” category.

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.