The Proof Podcast is a space for science-based conversation. Together with his guests, Simon Hill, a qualified physiotherapist and nutritionist, explores the health and longevity benefits that come with mastering physical exercise, nutrition, mindfulness, recovery, sleep, and alignment. Facts, nuance and trustworthy recommendations minus the hyperbole. All the proof you need to live better for longer.
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My Plaque Protocol, and Why I Started a PCSK9 Inhibitor | Simon Hill, MSc
Season 1
Monday, October 5, 2026 • Duration 56:59
A few weeks ago I published my own heart scans, and one number travelled further than the rest: a 48% drop in plaque over 16 and a half months. The question underneath that video was the obvious one. How? This episode is the answer, and it is also the part I could easily have left out.
Three companies analysed the same two scans. HeartFlow found a 48% reduction, Cleerly found a 20% increase, and QAngio found essentially no change at all. Same heart, same images, and a sixfold spread in the absolute amount of plaque they measured. I walk through my full protocol, explain which analysis I anchor to and why, and tell you why, despite that headline, I have started a PCSK9 inhibitor.
What We Cover:
Why cumulative ApoB exposure matters more than the cholesterol reading you have today
My nutrition, training, and sleep protocol, and the supplements I deliberately avoided
Why three platforms measuring the same heart came back with 11.5, 60, and 74 cubic millimetres
The published concern about AI overestimation of plaque, and which analysis Dr Matthew Budoff trusts
How my percentile swings 25 points depending on the reference database
Why I started a PCSK9 inhibitor, and how I chose it over a statin
Why you should be sceptical of dramatic short-interval scan results, including mine
All three analyses agreed on the thing that matters: the plaque burden is low, and it is not progressing rapidly. That agreement is worth far more than the headline.
Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Eight Sleep
Upgrade your sleep with the Pod 6 by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $200 off. You get 30 days to try it at home and return it if you don't love it.
Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
Upwork
Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life.
SwimClub
SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Why Your MRI Doesn't Mean You Need Surgery | Dr Howard Luks
Season 1
Monday, September 28, 2026 • Duration 01:26:34
Howard Luks is an orthopaedic surgeon with almost 30 years of experience, and a good deal of his week is spent telling people they do not need an operation. We work through the joints that bring most people into a clinic, knees, shoulders, Achilles tendons and ankles, and separate what a scan is actually telling you from what it is being used to justify.
Almost everyone over 40 has something on an MRI that will be described as a tear. Very few of those people need surgery, and plenty have no pain at all. Howard's case, drawn from three decades in clinic and the sham-surgery and physiotherapy-controlled trials behind it, is that our language has raced ahead of the biology, and that the words we use change how people move and live.
What We Cover
Why "tear" and "bone on bone" are the wrong words, and what they do to a person's behaviour
What sham surgery trials showed for meniscus tears, rotator cuff tears and bone spur removal
How metabolic health shapes both your pain and your ability to heal after surgery
Why tendons respond to load rather than rest
Cortisone, PRP, stem cells and peptides: what the evidence supports and what is marketing
Ice, anti-inflammatories and ankle sprains, and why early movement beats a boot
Plyometrics, balance and power, and why they matter more than strength after 50
This is a conversation about being careful with language and honest about uncertainty, and about keeping your capacity so you can keep doing the things you care about.
To connect with Howard Luks, read his writing on Substack or find him on X and Instagram.
If you enjoy the show, please leave a rating and review on Apple Podcasts or Spotify. It genuinely helps other people find these conversations.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Eight Sleep
Upgrade your sleep with the Pod 6 by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $200 off. You get 30 days to try it at home and return it if you don't love it.
Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.
Momentous ships to many countries worldwide depending on local import regulations.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Birth, Breastfeeding, and the Truth About Baby Food | Dr Federica Amati
Season 1
Monday, September 21, 2026 • Duration 01:22:31
This is part two of my conversation with Dr Federica Amati, Head Nutritionist at ZOE and author of the Sunday Times bestseller Every Body Should Know This. In part one we covered preconception, fertility, and pregnancy nutrition. Here we follow the first 1,000 days through to the end: birth, breastfeeding, weaning, and the environmental exposures behind all of it.
Much of this territory has become a source of guilt rather than clarity. Federica's framing is the one I keep returning to: this window is critical, but it is not fragile. Biology adapts, most of what shapes these years is structural, and where parents do have agency the evidence is more reassuring than the headlines suggest.
What we cover:
Why a critical window is not a fragile one, and what the first 1,000 days actually set
Choline, iodine, and omega-3 in pregnancy, and the "four eggs a day" myth
C-sections and the infant microbiome, and why the differences largely converge by age two
Breast milk as a living system, and an honest comparison with formula
Weaning without the marketing: the smoosh test, iron at six months, and early allergen introduction
Microplastics and endocrine disruptors, and the swaps that do the most work
Federica is exceptionally good at separating what the evidence supports from what the marketing claims, and she does it without ever making parents the villain.
To connect with Dr Federica Amati, follow her on Instagram at @dr.fede.amati or explore her work at ZOE. You can read more about the campaign she discusses in this episode at Plastic Free Babies, and her Sunday Times bestseller, Every Body Should Know This, is available wherever books are sold.
If this episode was useful, a rating or review on Apple Podcasts, or a follow on Spotify, makes a genuine difference to the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Upwork
Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life.
ProLon
ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF.
ProLon ships within the United States.
Skylight
Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.
Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.
Momentous ships to many countries worldwide depending on local import regulations.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
The Liver Disease 30% of Us Have and Never Feel | Prof Aleksander Krag
Season 1
Monday, September 14, 2026 • Duration 01:20:55
Around 30% of the world's population has too much fat in their liver, and almost none of them know it. Liver disease stays silent until it is very advanced, which is exactly why so many people are found too late.
In this episode I sit down with Prof Aleksander Krag, professor and department chair of gastroenterology and hepatology at Odense University Hospital and former Secretary General of the European Association for the Study of the Liver, to separate the frightening headline number from the thing that actually determines risk. It is not the fat. It is the scarring, and there is a simple test that can tell you whether you have any.
What we cover
Why a third of us have fat in our liver, and why that alone is not the thing to worry about
Steatosis versus fibrosis, and why only scarring predicts clinical liver disease
What blood-based alcohol biomarkers revealed about self-reported drinking
The single home measurement that tracks liver risk best
FIB-4, FibroScan, elastography, and ELF, explained plainly
How reversible liver damage really is, and where semaglutide and resmetirom fit
The policy levers Aleksander argues would prevent more disease than any clinic can
If you have ever wondered whether your drinking, your waistline, or your last set of liver enzymes is worth acting on, this conversation gives you a clear place to start.
To connect with Prof Aleksander Krag, visit the Centre for Liver Research (FLASH) at the University of Southern Denmark, follow him on X, or find him on LinkedIn.
If this episode was useful, please leave a rating and review on Apple Podcasts or Spotify. It genuinely helps more people find the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.
Momentous ships to many countries worldwide depending on local import regulations.
SwimClub
SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.
Eight Sleep
Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.
Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
The Case for Treating Cholesterol Before Plaque Appears | Dr Thomas Dayspring and Dr Dan Soffer
Season 1
Monday, September 7, 2026 • Duration 01:42:10
Almost all of us have atherosclerosis, and almost none of us are told so, because "normal" cholesterol is a population average rather than a physiological target. Dr Thomas Dayspring and Dr Dan Soffer, both Masters of the National Lipid Association, join me for a conversation devoted entirely to primary prevention.
They do not agree on everything, and that is the point. Tom argues ApoB is the cause of atherosclerosis. Dan calls it the necessary substrate. Between them you get an unusually honest look at how two experienced clinicians weigh evidence, uncertainty, and their own bias when treating someone who feels perfectly well.
What We Cover:
Why genes matter less for atherosclerosis than most people assume
Is ApoB causal, or simply necessary? The disagreement, in full
What "normal" cholesterol means, and the levels we are born with
LDL-C years: a five-second calculation you can run on yourself
What the 2026 dyslipidemia guideline changed
How they would manage a healthy man in his thirties with a family history and an ApoB of 100
Statin muscle symptoms, and the simple test that settles it
If you have ever been told your cholesterol is fine and wondered what that actually means, start here.
To connect with Dr Thomas Dayspring, find him on X, where he posts as @Drlipid. To connect with Dr Daniel Soffer, visit his Penn Medicine profile.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Skylight
Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.
Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.
Pique
Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.
Pique ships within the U.S. and to Australia, Canada, and select EU countries.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
Shopify
Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Bone Health, Falls, Medications & Healthy Longevity | Dr Deborah Kado
Season 1
Monday, August 31, 2026 • Duration 01:35:17
Everyone wants to talk about longevity. Almost no one wants to talk about gerontology, the field that has been studying how to age well for a century. Dr Deborah Kado, Stanford professor of medicine and geriatrician, joins me to bridge that gap.
From bone health and balance to deprescribing, gut microbiome research, and the surprising power of your attitude towards ageing, this is a masterclass in what actually matters for a long, well-lived life.
What We Cover:
Why "longevity science" is largely gerontology rebranded
A positive attitude towards ageing and its link to lower dementia risk
Balance, power training, and preventing falls and fractures
The truth about osteoporosis medications and the scare that drove millions away
Why extra weight after menopause can be protective
Vitamin D, sleep regularity, and the gut microbiome
This one will change how you think about growing older, whatever your age.
To connect with Dr Deborah Kado, visit her Stanford profile or find her on LinkedIn.
Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
ProLon
ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF.
ProLon ships within the United States.
SwimClub
SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Type 2 Diabetes Remission in the GLP-1 Era | Prof Roy Taylor
Season 1
Tuesday, August 25, 2026 • Duration 01:24:46
Professor Roy Taylor returns, three years after his first appearance, with the five-year DiRECT trial results and a clear-eyed assessment of where diet-driven type 2 diabetes remission stands in the GLP-1 era.
The evidence is now solid: type 2 diabetes is, for many, a reversible condition of excess fat in the liver and pancreas. But keeping it in remission demands keeping the weight off, and the new generation of weight loss drugs comes with marketing claims that Roy says have no evidence behind them.
What We Cover:
The Twin Cycle Hypothesis and personal fat threshold
Five-year DiRECT data: durable remission, halved hospital admissions, fewer cancers
Why regaining the weight means the diabetes returns
GLP-1s: what they genuinely do, and what's marketing
The muscle loss panic, put in perspective
Gestational diabetes and pre-pregnancy weight
Whether you have type 2 diabetes, care for someone who does, or simply want to understand one of the biggest shifts in modern medicine, this conversation delivers.
To learn more about Professor Roy Taylor's work, visit his research site at Newcastle University or read his book Life Without Diabetes. Clinicians can also explore his type 2 diabetes remission toolkit for general practice.
Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Upwork
Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.
Momentous ships to many countries worldwide depending on local import regulations.
HomeServe
Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you.
HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs.
Skylight
Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.
Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess
Season 1
Monday, August 17, 2026 • Duration 01:08:56
Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, registered dietitian and Senior Research Fellow at the University of Oxford, says the evidence is clear: a higher-protein, lower-carbohydrate diet can lower post-meal glucose by more than medication, no weight loss required.
We also tackle the noisier end of the blood sugar conversation: glucose spikes, fruit fear, insulin-first theories of obesity, and the panic about GLP-1s and muscle loss.
What We Cover:
Why glucose only causes direct harm at diabetic levels
How protein wakes up "sleepy" beta cells
What overfeeding trials reveal about insulin and obesity
Fruit, fibre, and fat quality: what matters and what doesn't
Menopause, PCOS, and shift work
The truth about GLP-1s and muscle loss
If you want a clear-eyed guide to metabolic health without the hype, this episode delivers.
To connect with Dr Nicola Guess, visit nicolaguess.com or find her on Instagram and YouTube.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
Shopify
Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.
Eight Sleep
Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.
Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford
Season 1
Monday, August 10, 2026 • Duration 02:03:43
About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly evaluated. In this episode I sit down with Dr Michael Eisenberg, a urologist, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, and Dr Natalie Crawford, a reproductive endocrinologist and co-founder of Fora Fertility in Austin, Texas.
This is the comprehensive male fertility resource I went looking for and couldn't find, and I have a personal stake in it. What surprised me most is that sperm health appears to be about much more than conception. It tracks with metabolic health, immune health, pregnancy outcomes, and in one Danish cohort, with age of death decades later.
What We Cover
What a semen analysis measures, and why ejaculating normally tells you nothing
Semen quality as a sixth vital sign, and the Danish study linking it to lifespan
Testosterone therapy, why it functions as a contraceptive, and how long recovery takes
Whether sperm counts are really declining, and the likely drivers
Cannabis, alcohol, heat, cycling, sleep, and body weight
Total motile sperm count, DNA fragmentation, and what to ask your lab for
Paternal age, sperm freezing, and timing your decisions
Sperm turn over roughly every three months, which makes this one of the most movable metrics in health. Whichever stage of life you're at, this conversation is worth your time.
To connect with Dr Michael Eisenberg, find him on Instagram or LinkedIn. To connect with Dr Natalie Crawford, you can find her book The Fertility Formula at nataliecrawfordmd.com/book, listen to her podcast As a Woman, or follow her on Instagram, TikTok, YouTube, and LinkedIn.
If this episode was useful, please leave a rating and review on Apple Podcasts. It genuinely helps more people find the show.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.
IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.
Pique
Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.
Pique ships within the U.S. and to Australia, Canada, and select EU countries.
Skylight
Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.
Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson
Season 1
Tuesday, August 4, 2026 • Duration 01:53:23
Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from confident hype, and in this conversation we tackle everything from new cholesterol-lowering drugs to gene editing, cognitive ageing, and the lean mass hyperresponder debate.
Along the way we get a few things off our chests about the misinformation that spreads faster than the careful answer ever can.
What We Cover
Why healthy ageing brains owe more to lifestyle than to genetics
How PCSK9 inhibitors work, and why plaque is more like geology than plumbing
Gene editing for cholesterol and functional cures for type 1 diabetes
The lean mass hyperresponder debate and what the Keto-CTA re-analysis shows
Why colorectal cancer is rising in younger adults
The 2026 dyslipidemia guidelines and why you should test your Lp(a) once
This is a grounded, evidence-first conversation, and I hope it helps you feel clearer and more confident about the decisions that actually move the needle. If you enjoy the episode, please take a moment to rate and review the show, it genuinely helps more people find it.
To connect with Dr Terry Simpson, visit terrysimpson.com, where you will find his bio, recipes, and plenty more. You can also follow him on Instagram, X, and TikTok, and read his writing on Substack.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
38Tera ships to the United States, Australia, and New Zealand.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.
Momentous ships to many countries worldwide depending on local import regulations.
Eight Sleep
Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.
Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.
LMNT
Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked.
LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com
Host of The Proof with Simon Hill
Author of The Proof is in the Plants
Subscribe & Connect:
YouTube
Apple Podcasts
Spotify
Instagram: @simonhill
Twitter: @theproof
Facebook: The Proof with Simon Hill
Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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