AJT Highlights – Details, episodes & analysis

In this Specialty Podcast, Dr. Dami Ko is joined by Dr. Katherine Rizzolo, and Dr. Leonela Villegas to discuss kidney transplantation for undocumented immigrants in the United States, particularly the challenges they face and ethical considerations.

Dr. Dami Ko is an assistant professor at Northeastern University, specializing in post-transplant care and quality of life.

Dr. Katherine Rizzolo is a nephrologist in Boston, MA.

Dr. Leonela Villegas is a Pediatric Nephrologist at Hartford, CT

References:

Long-term impact of immigration status on outcomes in pediatric kidney transplant recipients. 

Successful pathways to liver transplant for undocumented immigrants. 

Undocumented immigrants: A glaring inequity in transplant.

Hosts Roz and Alberto are joined by new Editorial Fellow Dr. Sofia Bin to discuss the key articles of the August issue of the American Journal of Transplantation.

Dr. Sofia Bin is an assistant professor of medical and surgical sciences at the University of Bologna.

[02:46] Gut microbiome alterations precede graft rejection in kidney transplantation patients

[10:31] Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: a multicenter international study

Editorial: Graft biopsy reimagined: Integrating morphology and molecular maps

[22:20] Does a changing donor pool explain the recent rise in the United States kidney nonuse rate?

[32:45] A scintigraphic look at the dead donor rule in donation after the circulatory determination of death with the use of normothermic regional perfusion: A single-center interventional trial

Editorial: Normothermic regional perfusion in donation after circulatory determination of death—Confirming the absence of brain reperfusion

[37:03] Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: initial insights from the International LDLT Registry

Hosts Roz and Josh are joined by Sergio Acuna, MD to discuss the key articles of the January issue of American Journal of Transplantation.

Dr. Sergio Acuna is a clinical instructor in abdominal transplant surgery at the University of Alabama at Birmingham

[03:21] The dangerous precedent of censoring scientific dissemination

[08:45] Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury

Editorial: Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration

[14:00] Probable antibody-mediated rejection in kidney transplantation is a rare and challenging phenotype to define: Findings from a single-center study

[19:54] The relationship of microvascular inflammation with antibody-mediated rejection in kidney transplantation

Editorial: Exploring microvascular inflammation and the spectrum of antibody-mediated rejection

[25:56] Long-term persistence of seroprotection against measles following measles-mumps-rubella vaccination administered before and after pediatric liver transplantation

[31:26] Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Hosts Roz and Josh are joined by Abraham Matar, MD to discuss the key articles of the December issue of American Journal of Transplantation.

Dr. Abraham ‘Abe’ Matar is a Transplant Surgery Fellow at the University of Minnesota

[02:15] Economic Evaluation of Weight Loss and Transplantation Strategies for Kidney Transplant Candidates with Obesity

Editorial: Selecting Weight Loss Strategies for Kidney Transplant Candidacy: Weighty decisions

[11:44] Electrostimulation suppresses allograft rejection via promoting lymphatic regulatory T cell migration mediated by lymphotoxin (LT)-LTb receptor signaling

[18:57] Ischemia Reperfusion Responses in Human Lung Transplants at the Single Cell Resolution

[28:36] The suggestion of mitigating disparity in the liver transplantation field among ABO blood type

Description:  Hosts Roz and Josh are joined by Sharon Weeks Groh, MD to discuss the key articles of the November issue of American Journal of Transplantation.

Dr. Sharon Weeks Groh is a transplant surgeon at Walter Reed

[02:08] Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared to laparoscopic or open - A single center prospective registry study of 3,448 cases

[09:34] Public Attitudes to Xenotransplantation: A National Survey in the United States

[18:09] Non-clinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1

[25:52] Establishing targets for goal-directed anesthesia in renal transplantation: a cohort analysis of high-saliency surgical time-courses.

Editorial: Intraoperative blood pressure management during kidney transplantation: grafts under pressure.

[36:53] Why partial heart transplantation could be regulated as organ transplantation

Hosts Roz and Josh are joined by Frances Lee, MD to discuss the key articles of the October issue of American Journal of Transplantation.

[00:02:31] Pre-transplant Use of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma: A Multicenter, Retrospective Cohort Study

Editorial: Integrating immune check inhibitors in liver transplantation for hepatocellular carcinoma: The right time and the right patient

[00:11:46] Association of Procurement Technique with Organ Yield and Cost Following Donation After Circulatory Death

Editorial: Dawn Has Arrived, Illuminating Thrilling Opportunities and Fresh Challenges in a New Era of U.S. Transplantation

[00:24:53] Common Definitions and Variables are Needed for the United States to Join the Conversation on Acute on Chronic Liver Failure

[00:33:15] Enhanced role of multipair donor swaps in response to size incompatibility: The first two 5-way and the first 6-way liver paired exchanges

[00:40:15] Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival

[00:48:22] Incomplete reporting of clinically significant acute rejection episodes in the National Kidney Transplant Registry

Hosts Roz and Josh are joined by Alissar El Chediak, MD to discuss the key articles of the September issue of the American Journal of Transplantation.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern

[02:55] – Liver Machine Perfusion Technology: Expanding the Donor Pool to Improve Access to Liver Transplantation

[08:01] – Editorial: Machine perfusion and liver transplant center behavior: Answers or more questions?

[11:01] - Obesity, Organ Failure, and Transplantation: A Review of the Role of Metabolic and Bariatric Surgery in Transplant Candidates and Recipients.

[18:48] – Virus Specific T Cell Therapy to Treat Refractory Viral infections in Solid Organ Transplant Recipients

[25:08] - Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant

[28:48] – Editorial: Virus-specific T-cell efficacy after solid organ transplantation: more questions than answers

[34:05] - Successful BK virus–specific T cell therapy in a kidney transplant recipient with progressive multifocal leukoencephalopathy

[37:50] - The prevalence of postacute sequelae of coronavirus disease 2019 in solid organ transplant recipients: Evaluation of risk in the National COVID Cohort Collaborative

Description:  Hosts Roz and Josh are joined by Maria Alejandra Mendoza, MD to discuss the key articles of the August issue of American Journal of Transplantation.

[01:57] Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes https://doi.org/10.1016/j.ajt.2024.02.022

[13:11] China Issued Rules on Human Organ Donation and Transplantation https://doi.org/10.1016/j.ajt.2024.04.002

[21:10] Advancing Mouse Models for Transplantation Research https://doi.org/10.1016/j.ajt.2024.01.006

[30:05] Differential induction of donor-reactive Foxp3+ Treg via blockade of CD154 vs. CD40 https://doi.org/10.1016/j.ajt.2024.03.033

[40:27] Total Robotic Liver Transplant: The Final Frontier of Minimally Invasive Surgery https://doi.org/10.1016/j.ajt.2024.03.030

Hosts Roz and Josh are joined by Mack Morris, MD to discuss the key articles of the July issue of American Journal of Transplantation.

[03:33] Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases https://doi.org/10.1016/j.ajt.2024.02.023 

[13:07] The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation https://doi.org/10.1016/j.ajt.2024.02.008 

[24:30] Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? https://doi.org/10.1016/j.ajt.2024.03.021 

[32:20] Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial https://doi.org/10.1016/j.ajt.2024.03.007 

[40:30] Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection https://doi.org/10.1016/j.ajt.2024.01.004 

In this specialty podcast, AJT Fellow and host David Cron is joined by Jesse Schold and Joel Adler to provide an overview policy evaluation in transplantation, including analytical approaches, pitfalls, and best practices.

References

Stewart et al. “Does anyone really know what (the kidney median waiting) time is?”  

Noreen et al. “Augmenting the United States transplant registry with external mortality data: A moving target ripe for further improvement”

Shifman et al. “Association of state Medicaid expansion policies with pediatric liver transplant outcomes”