The Trusted Pharmacist Podcast pulls back the curtain on the healthcare industry, exposing the flaws in the system and empowering listeners to take control of their health. Hosted by pharmacist Steve Hoffart, this show delivers science-backed insights, debunks medical myths, and highlights natural and medical solutions that truly work.
Through candid solo episodes and expert interviews, Steve provides actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Whether you're looking to improve your health, understand your body's needs, or make sense of conflicting medical advice, this podcast is your go-to source for honest, practical information.
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Données mises à jour le 02/10/2026
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Why You Wake Up at 3 AM & Can't Fall Back Asleep | Dr. Stasha Gominak Returns
jeudi 1 octobre 2026 • Durée 49:36
Dr Stasha Gominak is back, and together we fix a real patient's problem…live.
Last time she shared why your sleep is broken. This time she solves a single hour of your sleep, the 3am wake up.
If that's happening to you, you're not alone. The 3am wake up is the single most common sleep complaint we hear.
What You'll Discover In This Episode
How the biggest sleep supplement in America is actually overdosing us
The root cause of the 3am wake-up
Supplements you can STOP buying
The one vitamin to take at 3am
The real patient situation and Dr Stasha's sleep supplement stack
The vitamin critical for both mothers and children
Steve's most recommended sleep supplement
Click to learn more about Dr Gominak's RightSleep program, or click to explore Magnolia Pharmacy's Sleep Support collection of supplements.
Reminder: Patient examples, supplements and dosages are for educational purposes only.
About the Guest
Dr Stasha Gominak is a former practicing neurologist and the creator of RightSleep®, dividing her time between helping individuals, through virtual coaching sessions and teaching clinicians and coaches how to use RightSleep concepts to improve their patients' health and well being.
Dr Gominak completed a Neurology residency in 1989 at the Harvard-affiliated, Massachusetts General Hospital. In 2004 Dr. Gominak began to concentrate on treating neurological illness by improving sleep. She published a pivotal article in 2012 proposing that the global struggle with worsening sleep was linked to reduced sun exposure.
In 2016 she followed with a second article linking the change in the intestinal microbiome to the epidemic of poor sleep, and described a simple process for normalizing sleep and the intestinal bacterial population, called RightSleep®.
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
A Small-Town Pharmacist Broke Down on TikTok. Here's Why.
jeudi 24 septembre 2026 • Durée 36:47
Your pharmacy might be busier than ever..and going broke.
Small-town pharmacist Fair Jones went viral on TikTok the moment she couldn't take it anymore. People Magazine told her story. Now she joins me to explain what's happening behind the counter, and why your next prescription may not get filled.
If you're like many people, your pharmacist is your first call when you or your family are sick. As Fair points out, " There are times in our town, people that just don't have extra money lying around to go to the doctor for every single little thing. And so they'll just call us and say, "Hey Fair, this is what's going on. What do you think?"
We talk about what your hometown pharmacy actually does that mail order never will, what gets lost when a pharmacy closes, and how you can help prevent losing your pharmacy.
What You'll Discover In This Episode
Why your pharmacy might be struggling to pay for its next drug shipment
How you're forced into brand name drugs instead of inexpensive generics
The surprising share of prescriptions pharmacies lose money filling
Why Fair had to sign an NDA just to see her own reimbursement contract
How filling nine prescriptions for a stranded patient left her 88 cents profit
One easy thing you can do to help keep your pharmacy from closing its doors
Your hometown pharmacy isn't struggling because they stopped mattering. They're struggling because they're making a difference, but middlemen have made it nearly impossible to succeed while giving great care and service.
For more information or to get involved, visit , or ask your HR department who your PBM is.
This Decides If Your Hormones Work | Dr John Kim
jeudi 17 septembre 2026 • Durée 32:47
You've cleaned up your diet, optimized your sleep, taken all the right supplements. Maybe you're on hormone therapy or working with a functional medicine provider.
But you still have fatigue and brain fog, can't lose the extra weight, and your microbiome isn't improving. What's keeping your hormones from working properly?
I brought fellow pharmacist Dr John Kim, PharmD to share his perspective on cell mitochondria and how it governs hormone production, metabolism and receptor function. He's been through his own health journey, so he has a unique blend of expertise and personal experience as a patient searching for answers.
What You'll Discover In This Episode
The 'cell danger' response & what triggers it
How the body 'protects' itself from hormone therapy & supplements
Why progesterone can backfire & cause more anxiety
How Dr John's heart attack at 33 revealed long-hidden root causes
How overlooked drug interactions set patients up for failure
P.S. Are you looking for hormone therapy tailored to your unique needs?
Explore our bioidentical hormones and find the best solution for you:
Dr. John Kim, PharmD is a functional medicine pharmacist who helps patients uncover the root causes of their health challenges, with training in anti-aging and regenerative medicine. His own health struggles in 2015 deepened his understanding of complex, chronic illness, and his recovery from chronic infections, along with his work with families affected by autism spectrum disorder, shaped his focus on immune health and the body's underlying stress response. He is the founder of Kim Wellness, a virtual tele-wellness practice focused on hormone balance, immune health, and gut function, and speaks nationally and internationally on functional medicine. Learn more at
The Fiber–Depression Connection No One Talks About w/ Dr. Oscar Coetzee (Part 2)
jeudi 10 septembre 2026 • Durée 26:59
If nutrition can affect anxiety and depression, what should we actually measure, change, and investigate before reaching for another prescription?
Knowing that mental health can have nutritional and biological drivers is one thing. Knowing what to do with that information is another. Should we start with fiber, test vitamin D and iron, examine thyroid function, or investigate what is happening inside the cells? Without a clear approach, nutrition can easily become another world of guesswork, conflicting advice, and supposed quick fixes.
In Part 2, we move from understanding the nutrition, mental health connection to identifying the practical next steps. Dr. Oscar Coetzee explains why the average American may not be eating enough fiber to properly support the gut microbiome, which nutrient deficiencies he prioritizes when evaluating mental health symptoms, and how thyroid function can influence mood and energy. He also walks us through the organic acids test and what it can reveal about cellular energy, nutrient status, neurotransmitter pathways, stress, detoxification, and microbial activity.
In this episode, I continue my conversation with nutritionist, author, and speaker Dr. Oscar Coetzee. We explore how to investigate the biological factors affecting mental health without falling for quick fixes, why antidepressants should never be stopped abruptly, and the emerging probiotic research that Oscar believes could change how we support the gut and brain.
What You'll Discover in This Episode
Why fiber matters for the gut bacteria involved in producing the building blocks for serotonin and dopamine
How the average American's fiber intake compares with the amount Oscar believes is needed to improve the microbiome
Why fiber should be increased gradually instead of added in large amounts overnight
The connection Oscar sees between an underfed microbiome and rising levels of anxiety and depression
Why vitamin D deficiency and iron deficiency are among the first problems Oscar investigates
How anemia can affect mood, energy, and cognition, particularly in menstruating women
Before You Increase Your SSRI, Check Your Nutrient Levels w/ Dr. Oscar Coetzee
jeudi 3 septembre 2026 • Durée 27:58
What if the antidepressant isn't failing because it's the wrong medication, but because the body doesn't have enough of what it needs to make serotonin in the first place?
As a pharmacist, I've filled thousands of antidepressant prescriptions. But there is a question we rarely stop to ask before increasing a dose or trying another medication: Where does serotonin actually come from? An SSRI can help the brain reuse the serotonin that is already available, but the production of neurotransmitters also depends on what is happening elsewhere in the body.
This means symptoms we identify as anxiety or depression may sometimes have more than one possible driver. Low vitamin D, iron deficiency, unstable blood sugar, poor digestion, inflammation, and an imbalanced microbiome can all influence how we feel.
In this episode, I'm joined by nutritionist, author, and speaker Dr. Oscar Coetzee. We explore the missing nutritional and biological "third leg" of mental healthcare and why mood disorders can have a lot more to do with what's on your plate than you think.
What You'll Discover In This Episode
The overlooked question we should ask before assuming an antidepressant has "stopped working"
Why the gut microbiome helps provide the raw materials the body needs to make serotonin and dopamine
How nutrient deficiencies can interfere with neurotransmitter production even when someone is eating a seemingly healthy diet
Why poor digestion may matter just as much as the nutrients we consume
The "three-legged stool" of mental healthcare and the leg that is often missing
How low blood sugar, anemia, and vitamin deficiencies can mimic symptoms associated with anxiety or depression
Why a healthy gut depends on microbial balance, not simply eliminating every "bad" bacterium
How toxins released by certain gut bacteria may contribute to inflammation in the brain
Why two people with similar gut problems can experience very different mental health symptoms
Why You Never Hear About Estriol and How That Affects Your Health
jeudi 27 août 2026 • Durée 32:49
What if the estrogen missing from your hormone therapy wasn't left out because it failed, but because no one could build a profitable drug around it?
Your body naturally produces three estrogens: estrone, estradiol, and estriol. Yet most hormone therapy replaces only estradiol. It is easy to assume that estriol was studied, found ineffective, and discarded. But that is not what happened. It didn't necessarily lose a scientific argument; it lost a business one, and over time, we mistook that silence for proof.
That missing conversation matters because estrogen does not produce the same effect everywhere in the body. And this could help explain why some women see their hot flashes disappear on estradiol while continuing to struggle with mood changes, disrupted sleep, brain fog, gut problems, recurrent UTIs, or unexplained inflammation. Their treatment may not be failing; it may simply be addressing only part of the hormonal picture.
In this episode, I talk about why you never hear about estriol, why it's not about effectiveness, and when to consider asking your doctor about it.
What You'll Discover in This Episode
Why your body produces three estrogens, while most hormone therapy replaces only one
How estriol may have lost a business argument, not a scientific one
Why the absence of an FDA-approved estriol product does not automatically prove that estriol is ineffective
The crucial difference between a hormone binding to a receptor and fully activating it
How estrogen receptor alpha and estrogen receptor beta can produce very different effects throughout the body
Why estradiol can successfully relieve hot flashes while mood, sleep, memory, gut, or inflammatory symptoms remain
What research involving the brain, gut, immune system, and urogenital tissue suggests about receptor beta
What human multiple sclerosis trials may reveal about estriol's potential immune effects, and what those studies cannot yet prove
Why elevated cholesterol and metabolic health may further complicate estrogen receptor signaling
Estrogen Receptor Biology Brain, Mood, and Memory Gut Health Estriol and the Immune System Estriol Physiology and Ovarian Function Route of Administration and Inflammation An Important Note About the Evidence
Better Sleep with No Sleep Aids? Neurologist Explains.
jeudi 20 août 2026 • Durée 46:07
What if your go-to sleep aid was keeping you from deep, restorative sleep?
People come into the pharmacy every day looking for over-the-counter sleep aids or sleep supplements, so I reached out to neurologist and sleep expert Dr Stasha Gominak.
She has a very different view on what's disrupting our sleep, and practical steps we can take to transform our sleep.
What You'll Discover In This Episode
How moving indoors wrecked the brain chemical our body needs
How common sleep aids disrupt our body's natural sleep process
The link between Vitamin D and sleep
Sleep Trackers: The only metric that might actually be correct
The dosing mistake that might push you into Vitamin D deficiency
Practical dosing and timing for key vitamins
About the Guest
Dr Stasha Gominak is a former practicing neurologist and the creator of RightSleep®, dividing her time between helping individuals, through virtual coaching sessions and teaching clinicians and coaches how to use RightSleep concepts to improve their patients' health and well being.
Dr Gominak completed a Neurology residency in 1989 at the Harvard-affiliated, Massachusetts General Hospital. In 2004 Dr. Gominak began to concentrate on treating neurological illness by improving sleep. She published a pivotal article in 2012 proposing that the global struggle with worsening sleep was linked to reduced sun exposure.
In 2016 she followed with a second article linking the change in the intestinal microbiome to the epidemic of poor sleep, and described a simple process for normalizing sleep and the intestinal bacterial population, called RightSleep®.
Menopause, Mitochondria, and Why Your Energy Has Gone Down w/ Jennifer Scheinman
jeudi 13 août 2026 • Durée 43:00
Why do mitochondria come up so often in conversations about energy and longevity, but rarely when women are trying to understand what is happening to their bodies in menopause?
Most people have heard mitochondria described as the "powerhouse of the cell." But they also play a role in muscle function, recovery, cellular communication, and hormone production. As we age, damaged mitochondria can build up while the body becomes less efficient at clearing them away.
Could some of the fatigue, brain fog, reduced strength, and poor recovery women are told to accept as part of menopause or aging also be connected to declining mitochondrial health?
Perimenopause dietitian-nutritionist, Jen Scheinman, explains why mitochondria deserve a bigger place in the menopause conversation.
We explore the connection between estrogen and mitochondrial function, how mitophagy helps remove damaged mitochondria, and how urolithin A may support that process.
What You'll Discover In This Episode
Why mitochondria are often overlooked in menopause conversations
What mitochondria do beyond producing energy
How mitochondrial decline may contribute to fatigue and poor recovery
The connection between estrogen and mitochondrial function
What mitophagy is and why it slows with age
How urolithin A supports mitochondrial cleanup
How urolithin A differs from CoQ10 and NAD boosters
What the research suggests about strength, endurance, and recovery
Why mitochondrial support cannot replace sleep, exercise, and nutrition
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
About the Guest
is a perimenopause dietitian-nutritionist, longevity and healthy aging expert, and women's health advocate. She holds a master's degree in integrative and functional nutrition and is the founder of Next Jen Health.
The Hidden Side Effects of Cholesterol, Diabetes & Acid Reflux Medications
jeudi 6 août 2026 • Durée 29:40
What if the medication that's helping one health problem is quietly contributing to another?
Many of the most commonly prescribed medications for cholesterol, diabetes, acid reflux, allergies, anxiety, and pain can affect nutrient levels, hormones, sleep, memory, and energy over time. But common doesn't mean the medication is harmless.
In this episode, I explain why medications should never be put on autopilot. From statins and metformin to acid blockers and antidepressants, I share the questions every patient should be asking to better understand the long-term effects of the medications they take every day.
What You'll Discover In This Episode
Why "normal" blood work doesn't always tell the whole story
How common diabetes medications may contribute to fatigue, brain fog, and nerve problems
The hidden nutrient deficiencies linked to acid reflux medications
What statins can (and can't) tell you about your heart health and cholesterol
Why some allergy and sleep medications may affect memory as you get older
How certain antidepressants, pain medications, and anti-anxiety drugs can impact mood, balance, and cognition
The questions every patient should ask before automatically refilling a prescription
Why medications should be monitored just as carefully as the conditions they're treating
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Natural Thyroid May Be Changing: Is Your Treatment Actually Optimized? w/ Nat Jones
jeudi 30 juillet 2026 • Durée 29:59
What happens if the thyroid medication that finally helped you feel like yourself becomes harder to access?
Natural desiccated thyroid has been used for decades, and many women prefer it because it provides both T4 and active T3. Proposed FDA changes have raised questions about its future, but they also bring a much bigger issue into focus.
Why do so many women still struggle with fatigue, brain fog, weight changes, cold intolerance, and low energy even when they are taking thyroid medication and their lab results are considered "normal"?
Pharmacist and compounding expert Nat Jones explains what more complete thyroid care can look like for women in perimenopause and menopause. We explore why T4 alone may not be enough for every woman, how stress and cortisol can interfere with thyroid function, and how compounded T4/T3 therapy can offer a more individualized approach.
What You'll Discover In This Episode
Why some patients prefer natural desiccated thyroid to levothyroxine
T4 vs. T3: why having both can make a meaningful difference
What your options are if desiccated thyroid becomes harder to access
Why women still feel hypothyroid when their TSH is "normal"
How compounded T4 and T3 can be customized to the individual patient
Why standard thyroid ratios do not work equally well for everyone
The overlooked role of cortisol and chronic stress in thyroid treatment
The additional thyroid markers that may reveal what TSH misses
How ferritin and nutrient deficiencies can affect thyroid function
Why Hashimoto's requires more than simply replacing thyroid hormone
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
Fair Jones, together with husband Taylor, owns Sav-Mor Drugs and Gifts, an independent pharmacy in Grenada, MS. She's also a PBM reform advocate and mother fighting for patient access and fairness.
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
Why B vitamins also deserve attention when evaluating mental health symptoms
How selenium, iodine, and vitamin A support thyroid function—and why an underactive thyroid can resemble anxiety or depression
The role omega-3 fatty acids and zinc play in supporting brain-derived neurotrophic factor
How medication can provide short-term relief while nutritional deficiencies and other underlying problems are addressed
Why Oscar is concerned about prescribing and combining multiple psychiatric medications in children and teenagers
What an organic acids test can reveal that routine bloodwork may miss
How this test can offer insight into mitochondrial function, B vitamin status, neurotransmitter pathways, cortisol, detoxification, and microbial activity
Why mental health is too complex for TikTok remedies and one-size-fits-all solutions
Why anyone taking an SSRI should never reduce or stop it without working with the prescribing healthcare professional
How new technology is making it possible to deliver previously difficult-to-supplement anaerobic bacteria
Why emerging probiotic research could create new possibilities for mental, metabolic, and immune health
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
About the Guest
Dr. Oscar Coetzee is a nutritionist, published author, professor, and nationally recognized speaker, and VP of Clinical Education and Practitioner Support at Designs for Health. With more than 25 years of experience in nutritional science and research, he currently serves as a faculty member at the University of Bridgeport and Associate Director of the Nutrition Track within its Doctor of Health Sciences program. His work focuses on evidence-based nutritional science and developing nutrition intervention protocols for chronic disease. To learn more, visit https://www.designsforhealth.com/ or send an email to ocoetzee@designsforhealth.com.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
How genetics can reveal vulnerabilities without determining someone's future
Why Oscar now considers diet, gut health, and cellular function before turning to extensive genetic testing
When medication may be urgently necessary and why nutrition should complement, not replace, appropriate psychiatric care
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
About the Guest
Dr. Oscar Coetzee is a nutritionist, published author, professor, and nationally recognized speaker, and VP of Clinical Education and Practitioner Support at Designs for Health. With more than 25 years of experience in nutritional science and research, he currently serves as a faculty member at the University of Bridgeport and Associate Director of the Nutrition Track within its Doctor of Health Sciences program. His work focuses on evidence-based nutritional science and developing nutrition intervention protocols for chronic disease. To learn more, visit https://www.designsforhealth.com/ or send an email to ocoetzee@designsforhealth.com.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
The strongest scientific objections to combination hormone therapy—and why they deserve serious answers
Why estriol being a "weaker" estrogen may be a feature in some formulations, not necessarily a flaw
How poorly timed blood tests can make a compounded hormone cream appear ineffective
What to ask your provider if your current estrogen therapy is helping, but you still do not feel like yourself
PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.
Research Referenced in This Episode
Every study below includes a PubMed ID (PMID), which you can use to find the original paper at PubMed.
This episode discusses hormone therapy for educational purposes only. It is not medical advice or a substitute for a conversation with your healthcare provider about your symptoms, medical history, and treatment.
Binding affinities of 74 naturally occurring estrogen metabolites at estrogen receptors alpha and beta. Estriol demonstrated preferential binding to ERβ. Zhu BT, et al. Endocrinology. 2006. PMID: 16728493
Comparative transcriptional activity of estradiol at ERα and ERβ. Bhavnani BR, et al. Endocrinology. 2008. PMID: 18599548
Crystal structure research examining how estradiol interacts with ERβ. Souza PCT, et al. Scientific Reports. 2017. PMID: 28615710
27-hydroxycholesterol as a negative allosteric modifier of estradiol binding at ERβ. Starkey NJE, et al. Endocrinology. 2018. PMID: 29579190
Effects of an ERβ-selective agonist and estradiol on serotonergic neurons after ovariectomy. Suzuki H, et al. Molecular Psychiatry. 2013. PMID: 22665260
Antidepressant effects of estradiol and an ERβ-selective agonist after long-term ovarian hormone deprivation. Hou Y, et al. Journal of Psychiatry & Neuroscience. 2019. PMID: 30565903
Effects of ERβ activation on synaptic proteins, hippocampal signaling, and memory performance. Liu F, et al. Nature Neuroscience. 2008. PMID: 18297067
Estriol treatment, cortical atrophy, remyelination, and neuronal preservation. Meyer CE, et al. Laboratory Investigation. 2023. PMID: 37245852
ERβ-mediated neuroprotection independent of peripheral anti-inflammatory effects. Tiwari-Woodruff S, et al. Proceedings of the National Academy of Sciences. 2007. PMID: 17785421
Effects of ERα- and ERβ-selective agonists and estradiol on intestinal cell proliferation and apoptosis. Schleipen B, et al. Carcinogenesis. 2011. PMID: 21856997
The role of ERβ in intestinal tight junctions and gut permeability. Braniste V, et al. American Journal of Physiology—Gastrointestinal and Liver Physiology. 2011. PMID: 21252046
How the gut microbiome and the estrobolome influence circulating estrogen. Baker JM, et al. Maturitas. 2017. PMID: 28778332
Immune markers in postmenopausal women receiving oral estradiol. Itaborahy RM, de Medeiros SF. Climacteric. 2016. PMID: 27593223
Estriol treatment and changes in inflammatory and anti-inflammatory immune signals in women with multiple sclerosis. Soldan SS, et al. Journal of Immunology. 2003. PMID: 14634144
Estriol-generated tolerogenic dendritic cells in an autoimmune model. Papenfuss TL, et al. Journal of Immunology. 2011. PMID: 21317386
Estriol and pulmonary inflammatory gene expression during influenza infection. Vermillion MS, Ursin RL, Klein SL, et al. Endocrinology. 2018. PMID: 30032246
Estriol regulation of TNF and IL-6 responses in a murine endotoxemia model. Zuckerman SH, et al. Inflammation. 1996. PMID: 8979148
Review of estriol's immunomodulatory role across multiple sclerosis and other immune-mediated conditions. Ali E, Mangold C, Peiris AN. Menopause. 2017. PMID: 28375935
Human Clinical Trials of Estriol
Phase I trial of oral estriol in women with relapsing-remitting multiple sclerosis. Inflammatory brain lesions decreased during treatment, returned after withdrawal, and decreased again when treatment resumed. Sicotte NL, et al. Annals of Neurology. 2002. PMID: 12436153
Phase II randomized, placebo-controlled trial of estriol added to standard therapy in 164 women with relapsing-remitting multiple sclerosis. Voskuhl RR, et al. The Lancet Neurology. 2016. PMID: 26621682
Ovarian transplantation and immune function in post-reproductive mice. King A, et al. Frontiers in Endocrinology. 2023. PMID: 36755910
Changes in C-reactive protein among postmenopausal women using different hormone preparations in the PEPI trial. Circulation. 1999. PMID: 10500035
Effects of oral and transdermal estradiol on C-reactive protein and other inflammatory markers. Zegura B, et al. Atherosclerosis. 2003. PMID: 12732395
This research includes receptor pharmacology, animal studies, and human clinical trials conducted in specific patient populations, most notably women with multiple sclerosis. These different forms of evidence cannot automatically establish that estriol will produce the same benefits for every woman using menopausal hormone therapy.
There is currently no large randomized controlled trial directly comparing estradiol alone with combined estradiol-and-estriol therapy in postmenopausal women. There is also no equivalent trial establishing that estradiol alone replaces everything women may lose when natural production of all three estrogens declines.
The purpose of sharing this research is not to present estriol as a miracle or to suggest that women who are doing well on estradiol should change their treatment. It is to show why the scientific conversation remains open—and to give women and their healthcare providers the sources they need to examine the evidence for themselves.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
Jen Scheinman
Jen also serves as Director of Science Communication at Timeline, where she helps translate emerging research on mitochondrial health, nutrition, and aging into practical guidance people can use to support their health and longevity.
Her expertise has been featured in publications including Vogue, Glamour, Mindbodygreen, and Eat This, Not That! To learn more, visit timeline.com and follow Jennifer on Instagram.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
About the Guest
Nat Jones is a pharmacist and internationally recognized expert in pharmaceutical compounding. After more than 20 years as a compounding pharmacy owner, he joined Professional Compounding Centers of America (PCCA) in Houston, Texas, in 2014, where he serves in the Pharmacy Clinical Services Department.
Dermatology is Nat's primary specialty, with additional expertise in wound and scar care, autoimmune disease, endocrinology, pain management, low-dose naltrexone, GLP-1 therapies, methylene blue, ENT, urology, and men's health. He has spent decades delivering continuing education lectures at medical seminars and webinars around the world and is known for translating complex compounding science into practical strategies healthcare providers can use.
Nat was awarded Fellowship status by the International Academy of Compounding Pharmacists in 2010. He has authored numerous professional articles, e-books, case studies, and consumer publications, and has helped develop hundreds of innovative compounding formulations used by practitioners across the United States.
About Your Host
Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 1M on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.
Stay Ahead with Steve the Pharmacist!
Loving the show? Want more insights into how your body works? Head over to TheTrustedPharmacist.com and sign up with your email! You'll get the latest episodes, plus exclusive health tips to help you take charge of your wellness. Don't miss out – join me today!
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