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Explore every episode of the podcast This Week in Neuroscience

Dive into the complete episode list for This Week in Neuroscience. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

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1–50 of 74

TitlePub. DateDuration
TWiN 75: Arc, tau, and Alzheimer's29 sept. 202601:08:50

Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major histopathological hallmark of Alzheimer's disease.

Hosts: Vincent Racaniello and Tim Cheung

Guest: Melissa Cooper

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Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 74: Plastic astrocyte networks with Melissa Cooper30 juil. 202601:06:29

Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks.

Hosts: Vincent Racaniello and Tim Cheung

Guest: Melissa Cooper

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Music is by Ronald Jenkees

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TWiN 73: The price of a bigger brain25 juin 202601:26:34

TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 72: What cesarean babies miss01 juin 202601:09:10

TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.

.Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 71: Psychedelics rewire the brain from within29 avr. 202601:31:05

TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 70: Unraveling the axon wrap17 mars 202601:19:19

TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 69: Fibromyalgia and the microbiome05 mars 202601:11:29

TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 68: Firewall for the brain27 janv. 202601:14:21

TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 67: Interpreting situation-specific facial signals24 déc. 202501:30:40

TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 66: Neuroscience of overeating26 nov. 202501:24:11

TWiN reviews the underlying neurobiological mechanisms of overeating and obesity, the role of the hypothalamus and reward systems in controlling food intake and energy balance, and how dysregulation in these systems leads to overeating.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 65: Air pollutants promote dementia04 nov. 202501:37:18

TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain atrophy and impaired cognition and motor function.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 64: How the brain decides what we see08 oct. 202501:14:01

TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 63: Microbiome-targeted neurotherapy21 août 202501:31:51

TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 62: Memories of bad food23 juil. 202501:21:48

TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to illness delays of several days.

Hosts: Vincent Racaniello, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 61: Blood to the brain25 juin 202501:40:12

TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the brain and the periphery.

Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 60: You get the gist of it?03 juin 202501:05:21

TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuitry.

Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 59: AI co-scientist02 avr. 202501:14:45

Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries.

Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 58: Tongue-dragging rescue behavior10 mars 202501:14:21

TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection.

Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 57: Repetitive injury, herpes, and Alzheimer's04 févr. 202500:40:09

TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease.

Hosts: Vincent Racaniello and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 56: Astrocytes help neurons remember26 nov. 202401:00:44

TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall.

Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 55: A brain circuit for day/night balance28 oct. 202401:09:29

TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change.

Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

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Music is by Ronald Jenkees

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TWiN 54: How pregnancy transforms the brain01 oct. 202401:05:25

TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.

Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 53: Slowing time by cooling the brain29 juil. 202401:10:03

Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Joseph J. Paton and Felipe Rodrigues

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Music is by Ronald Jenkees

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TWiN 52: Probiotic improves social behavior in children with ASD24 juin 202401:05:50

Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.

Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Music is by Ronald Jenkees

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TWiN 51: Sensory processing dysfunction in autism spectrum disorders28 mai 202401:11:20

TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. 

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 50: Neurological sequelae after COVID-1929 avr. 202401:04:25

TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. 

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?25 mars 202401:31:25

TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. 

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 48: Traumatic brain injury and retroviruses19 févr. 202400:51:13

TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 47: Walking after spinal cord injury29 janv. 202400:55:25

TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 46: Neuronal activity promotes glioma progression01 janv. 202400:51:04

TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 45: Acupuncture modulates the immune system13 déc. 202300:52:24

TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. 

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 44: ADHD and persistent pain02 nov. 202301:00:41

TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 43: Pavlovian opioid tolerance04 oct. 202301:02:41

TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 42: Therapeutic effects of psychedelic drugs18 juil. 202300:56:34

TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 41: Alzheimer's and melanin-concentrating hormone20 juin 202301:18:30

Vivianne explains how early in Alzheimer's disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 40: Dopamine organizes behavior's syllables11 mai 202301:04:17

Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 39: Virus-like capsids trigger paraneoplastic disease28 avr. 202300:52:39

Junjie from Jason's lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu

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Music is by Ronald Jenkees

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TWiN 38: Bacterial immunity heals sensory neurons27 mars 202301:04:57

TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.

Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 37: Microglia at the crossroads23 janv. 202301:15:05

TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 36: Unbearable neurologists03 janv. 202301:29:33

TWiN answers listener questions about Alzheimer's disease, glaucoma and the microbiota, Dravet's Syndrome, schizophrenia, brain development, and chips implanted in the human brain.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 35: Neuromodulation in treatment-resistant depression06 déc. 202201:09:13

Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. 

Hosts: Jason Shepherd and Timothy Cheung

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  • Closed-loop neuromodulation for depression (Nat Med)
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 34: Microglia vital after spinal cord injury30 sept. 202201:09:17

TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 33: Viruses leaving the brain31 août 202200:58:11

TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 32: Relearning how to move after stroke02 août 202200:59:47

TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.

Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 31: HIV-1 co-receptor shapes window for memory linking29 juin 202201:11:52

TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease24 mai 202201:09:52

TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson's disease.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 29: Astrocytes close the critical period02 mai 202201:02:05
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 28: Oligodendrocyte performance enhancing exosomes04 avr. 202201:13:59

TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 27: Eyes wired to the auditory cortex03 mars 202201:03:47

TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.

Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 26: Immunological memory in the brain31 janv. 202200:53:49
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses.

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Music is by Ronald Jenkees

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