This Week in Neuroscience

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TWiN 54: How pregnancy transforms the brain

Episode 54

Tuesday, October 1, 2024 • Duration 01:05:25

TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.

Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison

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Pregnancy transforms the brain (Nature)
Hormone-mediated neural remodeling during pregnancy (Science)
Effects of pregnancy on brain activity (Nature Comm)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 53: Slowing time by cooling the brain

Episode 53

Monday, July 29, 2024 • Duration 01:10:03

Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Joseph J. Paton and Felipe Rodrigues

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Using temperature to analyze the neural basis of a time-based decision (Nat Neurosci)
Hot times for the dorsal striatum (Nat Neurosci)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 44: ADHD and persistent pain

Episode 44

Thursday, November 2, 2023 • Duration 01:00:41

TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Pain hypersensitivity in ADHD model (PNAS)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 43: Pavlovian opioid tolerance

Episode 43

Wednesday, October 4, 2023 • Duration 01:02:41

TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Associative opioid analgesic tolerance (Sci Adv)
Pavlovian-conditioned opioid tolerance (Sci Adv)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 42: Therapeutic effects of psychedelic drugs

Episode 42

Tuesday, July 18, 2023 • Duration 56:34

TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Download TWiN 042 (34 MB .mp3, 57 min)
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Psychedelic drugs open critical period (Nature)
Psychedelics reopen critical periods (News-Med)
LSD microdosing doesn’t work (U Chicago Med)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 41: Alzheimer's and melanin-concentrating hormone

Episode 41

Tuesday, June 20, 2023 • Duration 01:18:30

Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Melanin-concentrating hormone and Alzheimer’s disease (Nat Neurosci)
Alzforum
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 40: Dopamine organizes behavior's syllables

Episode 40

Thursday, May 11, 2023 • Duration 01:04:17

Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Spontaneous behavior without explicit reward (Nature)
Dopamine release conveys causal associations (Science)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 39: Virus-like capsids trigger paraneoplastic disease

Episode 39

Friday, April 28, 2023 • Duration 52:39

Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu

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Virus-like capsids in paraneoplastic disease (bioRxiv)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 38: Bacterial immunity heals sensory neurons

Episode 38

Monday, March 27, 2023 • Duration 01:04:57

TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.

Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Immunity to the microbiota promotes sensory neuron regeneration (Cell)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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TWiN 37: Microglia at the crossroads

Episode 37

Monday, January 23, 2023 • Duration 01:15:05

TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Microglia states and nomenclature (Nature)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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This Week in Neuroscience – Details, episodes & analysis

Podcast details

Recent rankings

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Shared links between episodes and podcasts

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Publication history

Latest published episodes

Related Shows Based on Content Similarities

Related Shows Based on Content Similarities

Apple Podcasts

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This Week in Neuroscience – Details, episodes & analysis

Podcast details

Recent rankings

Apple Podcasts

Spotify

Shared links between episodes and podcasts

Other93

Twitter5

Apple Podcast1

RSS feed quality and score

Publication history

Latest published episodes

Similar podcasts and content

Related Shows Based on Content Similarities

Related Shows Based on Content Similarities

Other93

Twitter5

Apple Podcast1

Apple Podcasts

Spotify