The Skin Science Podcast with Thomas Hitchcock, Ph.D. – Details, episodes & analysis

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with special guests, Angela Wilson McDonald, Global VP, Education and Customer Success, and Brian Jones, Ph.D., Global VP, R&D Pharma and Biomedical Innovation, about what the scientific literature says about microneedling, acne and granulomas. 

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

0:00 Introduction and disclaimers
1:04 Special guest, Dr. Brian Jones 
3:13 Define episode topic: the science behind microneedling and acne
6:00 Social media video detailing a skin reaction months after a microneedling treatment 
9:12 What is acne-prone skin? 
13:11 Can acne be spread?
14:49 Clip from S1 Ep2 "Acne" with Dr. James Leydon
17:27 What causes acne?
21:20 Inflammation and acne
23:44 Microneedling studies in individuals with acne-prone skin
28:16 Lack of scientific evidence that microneedling worsens acne 
35:15 Granulomas and risks of microneedling topicals into skin
40:33 Allergic reactions to metals 
43:48 Acne is a multifactorial condition 
45:09 Return to discussion about social media video 
49:00 Microneedling practices associated with granulomas
51:20 Closing remarks

REFERENCES

24:00 Mehran, G., Sepasgozar, S., Rohaninasab, M., Goodarzi, A., Ghassemi, M., Fotooei, M., & Behrangi, E. (2019). Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial. Iran J Dermatol, 22, 87–91. https://www.iranjd.ir/article_100199_17b3901512f6a7d987df9c24299a856d.pdf

25:49 Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Topical application of skin biome care regimen containing live cultures and ferments of Cutibacterium acnes defendens strain XYCM42 and the impact on clinical outcomes following microneedle-induced skin remodeling. The Journal of Clinical and Aesthetic Dermatology, 16(12), 18–30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729805/pdf/jcad_16_12_18.pdf

31:24 Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Study to determine the safety and efficacy of microneedling as an effective treatment for acne vulgaris. Skin Health and Disease, 3(5), e264. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549865/pdf/SKI2-3-e264.pdf

35:21 Heck, E., & Traboulsi, D. (2022). A case of a delayed granulomatous reaction on the face following microneedling: A case report. SAGE Open Medical Case Reports, 10, 2050313X221102489. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178993/pdf/10.1177_2050313X221102489.pdf

35:47 Yadav, S., & Dogra, S. (2016). A cutaneous reaction to microneedling for postacne scarring caused by nickel hypersensitivity. Aesthetic Surgery Journal, 36(4), NP168–NP170. https://doi.org/10.1093/asj/sjv229

38:40 Handal, M., Kyriakides, K., Cohen, J., & Hoffman, C. (2023). Sarcoidal granulomatous reaction

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with Jigna Patel, MD, of Vedaskin, and Angela Wilson McDonald, Global VP, Education and Customer Success, about retinoids and their impact on the skin's microbiota. 

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.


0:00 Intro
1:06 Special guest, Dr. Jigna Patel
4:57 Holistic approaches
6:10 Retinoids & patient considerations
10:12 Safety concerns
13:40 What do retinoids do?
18:29 Changing approaches to skincare
21:06 Do modern societal norms accelerate aging?
25:25 Accepting progression in skincare
31:55 Intermission for puzzle of the day
35:28 How Xycrobe technology came to be
43:50 Using commensal microbes for better skin health
48:20 Translating science into patient care
53:59 C. acnes and retinoid receptors
56:50 Closing remarks

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, the team discusses hyperhidrosis and an FDA-cleared treatment device with Dan Moyer, VP of Marketing and Sales at RA Fischer Co. 

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, the team discusses exosomes.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, we discuss hair loss with Kyle Gillett, MD, Board Certified Family Medicine, Board Certified Obesity Medicine.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, we discuss melasma with Amelia Hausauer, MD, a board-certified dermatologist.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, we discuss the skin barrier with Jennifer Holman, MD, FAAD, a board-certified dermatologist, board-certified micrographic dermatologic surgeon, and a fellow of the American Academy of Dermatology.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options.  In this episode, we discuss skin cancer with Jennifer Holman, MD, FAAD, a board-certified dermatologist, board-certified micrographic dermatologic surgeon, and a fellow of the American Academy of Dermatology.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a bi-monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options. In this episode, Dr. Hitchcock and Angela Wilson McDonald discuss biomecare and why Xycrobe, the novel technology found in BIOJUVE, is "holistic" biomecare.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a bi-monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options. In this episode, Dr. Hitchcock and Angela Wilson McDonald discuss the Xycrobe journey, a novel technology found in BIOJUVE, a topical probiotic for the skin biome and Crown's newest innovation. 

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.