In this special "Best of Season 7" episode, we’re revisiting the most impactful, inspiring, and thought-provoking moments from our standout interviews this season. From groundbreaking health hacks and personal growth strategies to expert insights on optimizing your life, these are the clips that sparked the biggest conversations. Whether you're a long-time listener or new to the show, this episode is packed with must-hear wisdom from our incredible guests. Tune in for a quick recap of what made Season 7 unforgettable!

- Check out SelfDecode: https://selfdecode.com/

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In this episode Joe sits down with Jack Smith, known for his pioneering biohacking experiments.

Jack shares his biohacking journey, highlighting unique health devices like the Pulse PEMF machine, EES cube, Altwork desk, and Oura Ring. 

He also delves into therapies such as ketamine for mental wellness, GAINSWave, and resistant starch for gut health. 

Through discussions on neurofeedback, silent retreats, and advanced wellness practices, Jack underscores his dedication to health optimization techniques and consistent lab testing.

You can follow his ongoing experiments on X @_jacksmith

Interested in joining the upcoming AIWO retreat? Click here to schedule a call.

- Check out SelfDecode: https://selfdecode.com/

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This is the first episode of a three-part series with Elizma Lambert, where we delve into the world of the Organic Acids Test (OAT) and its crucial role in optimizing health.

In this episode, we get started on our analysis of Organic Acids Test (OAT) and its essential role in naturopathic medicine and precision health. 

Elizma Lambert, a seasoned expert with over 20 years of experience, discusses the legitimacy and applications of functional health tests, especially the OAT test. 

First, we specifically look at fungal infections like Candida, and look at how these tests diagnose complex conditions by examining the intricate relationships with symptoms and signals. 

We'll explore the benefits of a holistic approach to health, moving beyond quick fixes to address genetic predispositions through multi-dimensional health strategies. 

Find out what’s in Joe’s mood toolkit! Joe Cohen has been doing health experiments on himself for over 20 years, and he’s finally sharing all his knowledge with you.

In this episode, Joe walks you through lifestyle changes and 3 of his favorite supplements for mood: 5-HTP, thiamine, and resistant starch & butyrate. He discusses his megadosing experiments, dosages, and his problem with the RDA.

He explains why he takes each supplement, the mechanisms of action of these supplements, and the effects they have on his mood. Plus, discover the one problem Joe has with resistant starch.

Find out how Joe determines if he’s deficient in a nutrient, and the importance of learning your genetic predispositions and tracking your labs when building your regimen.

Learn all about Joe’s favorite mood stabilizer supplements!

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Have you heard of scientific wellness? In this episode, Nathan Price and Joe discuss whether the conventional approach of using pharmaceuticals to treat chronic diseases is effective, or if a preventative approach to complex conditions such as cardiovascular disease and Alzheimer’s is the best choice.

Nathan explains how genes can help predict the success of lifestyle-based interventions and talks about the accuracy of polygenic risk scores vs single variants for disease prediction, and how genetics can be used in healthcare.

Nathan and Joe also talk about nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), DHEA, and other supplements. Plus, Nathan explains the controversy of choline, carnitine, and TMAO, and if you should be worried.

Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. He was named one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine and was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.

- Preorder The Age of Scientific Wellness

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Should you be scared of psychedelics? In this episode, Tim Gray and Joe talk about how to get more REM and deep sleep, and Tim discusses his experience with methylene blue. They talk about the pros and cons of alcohol and their experience with different psychedelics.

Tim shares his experience with conventional medicine, the top things he’s trying to optimize in his health and his strategies for kidney health, gut health, and more. He talks about how he used to track 35 biomarkers every day, and which ones he still continues to monitor.

They discuss methylation, the MTHFR gene & SNPs, and how genetics and your environment can affect your overall health and how you respond to supplements.

Tim Gray is the UK’s leading biohacker and the founder of the popular Health Optimisation Summit, The Biohacker London Meetup group, and London’s first private Hyperbaric Oxygen Clinic. He is dedicated health optimizing biohacker, a psychology specialist, entrepreneur, and global speaker.

- Check out the Health Optimisation Summit (Use code SELFDECODE for 10% off your ticket)

- Find Tim on Instagram

- Check out SelfDecode

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Are supplements a waste of time and money? In this episode, Shawn Wells and Joe discuss whether taking supplements every day is bad for your health, and Joe shares the one time a supplement caused his liver enzymes to spike (it’s not what you’d expect!).

Shawn talks about the problem with certain supplement companies and lets you in on important things to look out for when choosing a supplement. They talk about all kinds of supplements, including lipoic acid, dihydroberberine, paraxanthine, ergothioneine, NAD, and more, discussing their effects, dosages, and how they work in the body.

Shawn and Joe also discuss the importance of optimal mitochondria function and why you should pay attention to it, and Shawn shares his ultimate mitochondrial supplement stack.

Shawn Wells, MPH, LDN, RD, CISSN, FISSN, is the world’s leading nutrition biochemist and an expert on health optimization. He’s formulated over 700 supplements, foods, and beverages, and is the author of The Energy Formula.

- Check out SelfDecode

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Do supplements work the same for everyone? In this episode, Lucas Aoun shares his favorite supplements to improve cognitive function and focus, and he and Joe dig deep into how these compounds work in the body, discussing the research, dosages, and what to look out for.

They discuss dopamine and the mechanisms behind dopamine supplements and share their different experiences experimenting with supplements. Plus, listen to the benefits of increasing dopamine levels steadily vs taking supplements that cause a spike.

Lucas and Joe also talk about how to optimize testosterone levels, what causes low testosterone, and Lucas shares one surprising hack to increase your testosterone levels. Plus, find out one health hack Joe coins as “bromeopathy”.

Lucas Aoun is the founder of Ergogenic Health and Australia's leading biohacker & men's health expert.

This interview is not intended as medical advice.

- Find Lucas on YouTube

- Check out SelfDecode

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Low carb? Keto? Low fat? Fasting? In this episode, Katie Wells and Joe talk about her experience with dieting, some of the benefits she gets from intermittent fasting, and they discuss the controversial topic of cholesterol (spoiler: lower is not necessarily better).

Katie shares some of her favorite health hacks, and they talk about how genetics can influence a person’s health and how to use this information to live optimally. They also discuss which and how to track labs, the importance of optimal vs normal ranges, and what Katie does to hack her sleep & mood.

Katie Wells is the founder and CEO of wellnessmama.com and wellnesse.com. A mom of 6, she took her health into her own hands and started researching to find the answers to her health struggles. She has written over 1,500 blog posts, 3 books, and was named one of the most influential people in health and wellness.

This interview is not intended as medical advice.

- Check out SelfDecode

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Timestamps:

(0:00) - Introduction

(1:04) - How Katie got into health

(3:53) - The Personalized Health Podcast?

(4:57) - Shifting of health goals

(6:44) - Katie’s current health goals

(8:14) - Joe shares his health journey

(9:04) - What labs to track for anti-aging?

(10:32) - Alcohol and saturated fats affect on health

(12:31) - Katie Wells thoughts on LDL cholesterol

(13:24) - Over-dieting and under nourishing

(16:52) - Unsullied by paid sponsors

(17:18) - Megadosing and metabolic flexibility

(18:45) - Katies daily supplement intake & fasting

(20:01) - The mental and spiritual benefits of a long fast

(22:15) - Joe’s experience with fasting

(23:42) - What supplements does Katie take now?

(24:39) - Pregnenolone dosages & benefits

(25:40) - Nootropic stack for focus

(26:37) - Tips to improve sleep from Katie

(28:45) - Katie’s most successful health “experiments”

(30:09) - The importance of protein in your diet

(31:40) - The last time Katie changed her mind about a health topic

(32:42) - The best health hack Katie wished she found earlier

(34:52) - Katie’s top hacks to optimize mood

(36:36) - The difference between normal and optimal lab ranges

(37:45) - How using SelfDecode can help optimize your lab levels

(38:58) - The most interesting DNA discovery

(41:10) - Katie’s expectations on her life span

(43:15) - Characteristics that make you successful

Is high cholesterol really bad for you? In this episode, Joe and Siim Land discuss what causes high cholesterol, which biomarkers to track for longevity, and the biggest mistake people make when trying to lose weight.

Siim shares one surprising mineral that can help lower cholesterol and talks about how intermittent fasting helps his mental & physical performance. Then, Siim and Joe discuss a top supplement for longevity and healthspan.

Siim Land is a renowned public speaker and expert in biohacking, health optimization, and overall performance optimization. He is also the author of Metabolic Autophagy and The Immunity Fix with Dr. James Dinicolantonio.

This interview is not intended as medical advice.

- Check out SelfDecode

- Join Joe’s online community

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Timestamps:

(0:00) - Introduction

(0:41) - Why Siim Got Into Biohacking

(2:35) - What markers should you measure for longevity?

(8:28) - Taking blood tests every year to track improvements

(10:40) - The top supplement to improve longevity

(13:21) - Unsullied by paid sponsors

(13:47) - Cholesterol in the biohacking world

(14:49) - Intermittent fasting, fats, and lowering cholesterol

(17:30) - Zinc and Copper ratio

(18:53) - Does lower T3 contribute to high cholesterol?

(20:03) - One supplement with high evidence of increasing lifespan

(21:00) - What Siim tracks on a regular basis

(23:09) - Siim’s HRV numbers

(24:20) - How Siim improves mental performance

(26:51) - How Siim improves physical performance

(30:35) - The biggest mistake people make with fat loss

(35:21) - Genetics affect on portion control in diets

(37:06) - How often is Siim physically active per day?

(38:31) - How you process carbs differently based on your body composition

(41:00) - Sleephacking tips from Siim Land

(46:20) - Improving your immunity

Kiwi as a biohack for sleep? Bet you didn’t know that one! In this episode, Joe and Teemu Arina talk all about biohacking your sleep, low & high HRV ranges, why heart rate variability is important for your overall health, and discuss some of Teemu’s favorite biohacks for the body & brain.

Teemu tells Joe why he got into biohacking, his secret to handling stress, and what he thinks is the best approach to optimizing his mental and physical performance. He also gives you a glimpse of what his supplement stack looks like and lets you in on one of his favorite supplements.

Teemu Arina is a thriving speaker and the creator and organizer of the Biohacker Summit. He’s also the author of the Biohacker's Handbook: Upgrade Yourself and Unleash Your Inner Potential.

This interview is not intended as medical advice.

- Join Joe at the Biohacker Summit (Use code SELFDECODE10 for 10% off)

- Check out SelfDecode

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Timestamps:

(0:00) - Introduction

(1:42) - How Teemu got into biohacking

(7:43) - Optimizing the physical to improve the mental

(10:10) - How to improve your creativity

(13:03) - Personalizing your biohacking tools

(21:18) - Unsullied by paid sponsors

(21:45) - What is HRV and how Teemu increase his HRV

(26:49) - What are Joe’s strategies for improving HRV

(32:54) - The strength of the mind and negative effects of measuring

(34:44) -  How the environment affects your sleep quality

(36:38) - The best biohacks for sleep

(41:00) - Melatonin’s effect on the body

(42:51) - What supplements does Teemu take every day?

(45:41) - Discount code for Biohacker Summit

Are EMFs harmful? Should you wear sunscreen? In this episode, Joe and Dr. Joseph Mercola discuss these and other controversial topics within the health industry. Dive deep into the importance of sun exposure (it’s not just vitamin D), vegetable oils, and learn valuable insights to hack your diet.

Dr. Mercola shares his secret for better vitamin D levels, discusses the problems with linoleic acid and which foods to avoid, and talks about the one supplement he hasn’t taken in 15 years. Plus, listen to the top mistakes people make when trying to biohack their health.

Dr. Mercola is a New York Times bestselling author and the founder of the natural health website Mercola.com, one of the world’s leading natural health website with millions of monthly visitors.

Timestamps:

(0:00) - Introduction

(2:27) - The importance of the sun and Vitamin D

(7:03) - Mendelian Randomization Studies with Vitamin D

(10:20) - Dr. Mercola & The New York Times

(11:45) - EMFs vs. Vaccines

(14:25) - Tracking the effects of EMFs, Vegetable Oil, and Vaccines

(15:32) - Unsullied by paid sponsors

(16:00) - How long do the effects of Vegetable Oil last?

(19:39) - The negative effects of Vegetable Oils

(21:40) - What does Linoleic Acid do to your body?

(26:34) - How Dr. Mercola changed his diet to remove vegetable oils and decrease linoleic acid

(32:23) - Why studies on Vegetable Oil make it seem less harmful

(34:06) - LDL Cholesterol levels

(37:33) - The top 5 worst things people are doing for their health

(44:37) - Iron, Ferritin, and Hemoglobin

This interview is not intended as medical advice.

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In this episode, we dive deep into the world of precision health with Dr. Michael Snyder, a renowned professor of genetics at Stanford University and the chair of the genetics department. 

Join us as Dr. Snyder shares his groundbreaking insights on the latest advancements in precision medicine, biohacking, and personalized healthcare. 

Discover how cutting-edge technology, supplements, and genetic research can optimize your longevity and overall wellness. 

Tune in to learn how you can leverage precision medicine to enhance your longevity and improve your health. Don't miss out on the transformative potential of these innovations to help you live a longer, healthier life.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe speaks with Jean Fallacara, a multifaceted entrepreneur, neuroscientist, and calisthenics enthusiast. 

Jean shares insights on how he maintains peak performance through biohacking, focusing on supplements, exercise routines, and meditation practices. 

Joe and Jean dive deep into the realms of precision health, genetic testing, and maintaining a balanced, enjoyable lifestyle while pursuing optimal health. 

Tune in for an engaging discussion on fitness tips, the importance of diet, and how to transform your health regimen!

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/

Timestamps:

(0:00) - Introduction

(19:44) - Jean's top supplements

(30:55) - Jean's diet

(35:41) - Mindset hacks

In this episode, Joe dives into the complex world of proline supplementation.

He discusses the impacts proline has on collagen synthesis, aiming for improved skin health, enhanced wound healing, and better exercise recovery. 

However, the journey took an unexpected turn as Joe explains the biomechanics behind why he experienced several side effects such as anxiety, restlessness, and hypochondriac behaviors.

Throughout the episode, Joe explores:

• The intended benefits of proline for collagen synthesis and recovery

• The biochemical interaction of proline with lysine and vitamin C as per the Linus Pauling protocol

• The severe side effects experienced due to high doses of proline and the genetic predisposition affecting glutamate metabolism

• Strategies attempted to mitigate these effects

Join Joe as he unpacks the lessons learned from his proline supplementation experiment, shedding light on the potential risks and the importance of understanding one's genetic makeup before undertaking such regimens.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Join Joe as he takes a closer look at saffron, a spice revered not just for its flavor but for its impressive health benefits. 

In this deep dive, Joe explores how saffron could potentially outshine caffeine in enhancing mental clarity and focus. 

This episode goes in-depth on how saffron impacts various aspects of health, from improving sleep quality to reducing gut inflammation and boosting immune function.

Discover the comprehensive effects of saffron on:

• Mental Focus: How saffron compares to caffeine in enhancing cognitive performance.

• Sleep Quality: The role of saffron in promoting restful sleep and adjusting sleep cycles.

• Gut Health & Immunity: Insights into saffron’s anti-inflammatory properties and its implications for gut health and immune system support.

• Exercise Recovery: Exploring the potential benefits of saffron in reducing muscle soreness and speeding up recovery times.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Join Joe as he delves into his journey with MSM (Methyl Sulfonyl Methane) supplementation, a key to detoxing the body and enhancing recovery. 

In this episode, Joe discusses:

• The Impact of Heavy Metals on Health: Understanding the dangers of heavy metals and the importance of detoxing them from our bodies.

• MSM as a Detox & Methylation Aid: How MSM supplementation helps clear heavy metals and play a vital role in methylation.

• Recovery and Resilience Through MSM: How MSM aids in the recovery of tendon and joint injuries, contributing to better exercise outcomes.

• Combining Sulfur Sources for Optimal Detox: Strategies in integrating MSM with other sulfur sources.

• Enhanced Health Markers: Insights into how MSM positively influences key health markers like homocysteine, DHEA sulfate, ALT, and HSCRP.

Discover the powerful role of MSM in detoxing heavy metals and enhancing physical recovery. 

Tune in to learn how this supplement could revolutionize your approach to health and detoxification.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Buy Jo’s Resistant Starch on Amazon

Join Joe as he explores the powerful benefits of resistant starch as a natural alternative to Ozempic. 

In this episode, Joe dives into how resistant starch not only supports weight management and cognitive function but also promotes gut health—all without the side effects associated with pharmaceutical options like Ozempic.

Joe discusses:

• Resistant Starch for Health: How this natural supplement enhances the production of butyrate, GLP-1, and how these play significant roles in weight loss, muscle growth, and overall health improvement.

• Cognitive and Mood Enhancement: Insights into how increasing BDNF levels through butyrate production can boost cognitive functions and mood.

• Comparison with Ozempic: Joe compares the effects and side effects of resistant starch with Ozempic, providing a detailed analysis based on his personal experiences and scientific research.

• Practical Advice on Dosage: Detailing the specific dosage of resistant starch used in a recent study published in Nature in 2024, which demonstrated substantial benefits in weight management.

Tune in to learn why resistant starch might be the key to achieving your health goals naturally, making it a foundational supplement for enhancing immune function, preventing chronic diseases, and improving cognitive health.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Joe has an in-depth conversation with Dr. Rita Marie, a licensed doctor of chiropractic and the founder of the Institute of Nutritional Endocrinology, about the importance of personalized healthcare in addressing insulin, thyroid, adrenal, and digestive imbalances through the integration of genetics and lifestyle changes. 

Dr. Rita Marie discusses her approach to helping patients by not only looking at conventional lab tests but also incorporating genetics and lifestyle factors such as diet, sleep, and stress management to create a comprehensive health strategy. 

She emphasizes the necessity of moving beyond one-size-fits-all solutions to tackle health challenges, the motivational power of understanding one's genetic predispositions, and the significance of practitioners being curious and knowledgeable about nutritional biochemistry and genetics. 

Additionally, the conversation delves into the necessity of optimizing health before issues become irreversible and highlights some of the common markers and supplements considered in Dr. Rita Marie's practice.

- If you’re a health practitioner, visit inemethod.com

- Visit https://drritamarie.com/

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/
- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues. 

Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin. 

He concludes by weighing the pros and cons of AKG.

Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we delve into the pivotal role of the BHMT gene within the body's methylation process. 

We discuss how the BHMT enzyme is essential for catalyzing a vital reaction that transforms homocysteine into methionine. 

Additionally, we cover the importance of betaine in enhancing the methylation cycle. Betaine acts as a methyl donor, particularly in the reaction facilitated by the BHMT enzyme, making it crucial for reducing homocysteine levels and supporting cardiovascular and neurological health.

We also explore the complexity of methylation pathways and emphasize the need for a comprehensive evaluation of multiple genes to truly understand and optimize methylation.

Be sure to follow our podcast for more expert insights into how betaine, methylation, and genetics can be leveraged to optimize both body and brain health.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Aaron Michael and Dr. Saida Desilet discuss practical tips for enhancing intimacy, overcoming common sexual challenges, and sustaining long-term passion. 

Gain insights from their combined 50 years of experience in revolutionizing sex coaching, relationships, and intimacy. 

Learn about natural methods to boost sexual health, the impact of neurochemistry, and the role of emotional openness in sexual satisfaction. 

Whether you're single, in a relationship, or looking to optimize your intimate experiences, this episode provides invaluable knowledge on creating dynamic and fulfilling connections.

- Visit https://embodiedlove.love/

- Follow Dr. Saida Desilets on Instagram

- Follow Aaron Michael on Instagram

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/

Timestamps:

00:00 Introduction

01:09 Common Mistakes in Sexual Relationships

02:48 Health and Its Impact on Sex Drive

05:00 The Role of Neurochemistry in Sexual Health

06:21 Substances and Their Effects on Sexual Function

15:03 Techniques for Enhancing Sexual Experience

26:58 Emotional Connection and Sexual Openness

34:41 Healing from Trauma and Self-Discovery

35:46 Exploring Mental Arousal and Touch

39:33 Understanding Erotic Fingerprints

40:13 Preventing Boredom in Long-Term Relationships

41:19 The Dynamics of Sexual Desire

58:20 The Role of Smell in Attraction

01:00:51 Navigating Threesomes and Sexual Exploration

In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease. 

Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels.

Joe draws on personal experiences to compare the negatives against the significant positives of niacin, as he explores niacin's biochemical effects, particularly its interaction with proteins such as 2PY, 4PY, and VCAM1, all linked to cardiovascular health. 

Throughout the episode, Joe examines the importance of dosage, sharing insights into the varying effects of low versus high doses of niacin. 

Join Joe as he navigates the complexities of niacin use, advocating for a well-informed, nuanced approach to its benefits and risks.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. 

Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. 

We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making. 

Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. 

Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. 

Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. 

Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders. 

The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions. 

Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/
- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe takes questions from SelfDecode members, answering questions like:

• What makes SelfDecode different from other DNA companies?

• How does the recommendations engine work?

• Can you find out if a certain supplement is right for you?

Plus, he shares some of his genetic predispositions and how they correlate with his lab levels!

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1.

We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators. 

Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups. 

We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

This episode was originally published on April 12, 2015.

Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry. 

They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold exposure, water quality, and the necessity of questioning mainstream nutritional advice. 

Next, they focus on aligning with nature's design through sunlight exposure, understanding electron flow, optimizing DHA intake, and reducing exposure to non-native EMFs. 

These conversations aim to encourage curiosity over conforming, urging listeners to consider the interconnectedness of their biology with their environment in the pursuit of optimal health.

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters. 

Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition. 

We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health. 

From increased breakdown linked to mood disorders to decreased activity associated with elevated neurotransmitter levels, we unravel the complex interplay between genes and mental well-being.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Joe dives into the world of personalized wellness with Lauren Sambataro and Renee Belz, known as The Biohacker Babes.

With roots in wellness and holistic dentistry, The Biohacker Babes bring their wealth of expertise as health entrepreneurs, nutritional consultants, and holistic lifestyle coaches to the table.

In this enlightening conversation, we explore the pivotal role of lab testing in crafting personalized health regimens, emphasizing essential tests such as CBC, CMP, and functional lab tests.

The Biohacker Babes also dive into the complexities of hormone regulation, genetic predispositions, and the profound impact of stress, diet, and environment on overall health, as well as discuss advanced testing methodologies including organic acids tests, the GI MAP test, and the Dutch test, designed to fine-tune health interventions for maximum effectiveness.

Join us as we navigate the landscape of personalized wellness with the Biohacker Babes, unlocking the secrets to a vibrant, thriving life.

- Visit https://thebiohackerbabes.com/

- Check out @biohacker_babes on Instagram

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Intro

(1:10) - Important lab tests for Biohacker Babes

(5:45) - Digestion

(10:30) - Amino acids

(15:09) - Analyzing Joes biochemistry

(22:47) - Heavy metals testing

(29:52) - CGM & HRV

(41:57) - Epigenetic aging tests

(44:42) - Continuing with digestion

(51:55) - Food sensitivities

(55:01) - GI Mapping

In this episode of The Joe Cohen Show, we dive deep into the world of dopamine.

We'll be focusing on the role of genetics, specifically the DRD2 gene, in regulating dopamine levels and how it affects your brain's reward system, motivation, and susceptibility to addiction.

Here's what you can expect to learn:

• How the DRD2 gene influences dopamine D2 receptors and their impact on pleasure-seeking behaviors.

• Understanding the variants of the DRD2 gene and its link to dopamine receptor.

• How genetics can affect motivation, reward processing, and potentially lead to a dopamine imbalance.

• The importance of maintaining balanced dopamine levels for optimal cognitive function.

Join us as we explore the fascinating world of dopamine and genetics! 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Join us for an enlightening roundtable discussion featuring health experts Joe Cohen, Kris Gethin, Tim Gray, and Siim Land as they dive deep into the world of health optimization. 

In this episode, our expert panel explores a wide range of health tests and biomarkers, from basic to advanced, and what they mean for your health, including VO2 max assessments, heart rate variability, full-body MRI scans, gut microbiome analysis, and food sensitivity testing.

We also discuss topics like EMF and heavy metal sensitivity, shedding light on how these factors can impact overall health. 

Get exclusive insights into the advanced wellness center AIWO and its groundbreaking solutions, and discover how AIWO's cutting-edge approach is revolutionizing health and wellness.

But it's not just about theory—our panelists also share their personal experiences and tips gained throughout their own health journeys. From overcoming obstacles to achieving peak performance, they provide actionable advice to help you optimize your health and live your best life.

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) Introduction

(00:21) The AIWO Experience

(47:31) Heart Rate Variability

(53:11) VO2 max

(56:22) Joe's Favorite Supplement for Recovery

(58:39) Sound changes here

(01:05:33) EMF & Heavy Metal Sensitivity

(01:13:29) Digestive Enzymes

(01:20:22) Kris' Top Health Hack

In this episode, Joe sits down with Chris Mirabile, founder and CEO of Novos Labs, to explore cutting-edge strategies for reducing your biological age and slowing the pace of aging. 

Chris shares his personal journey and the science behind his success, diving into the mechanisms of aging and the powerful supplements that can make a difference. 

They discuss the benefits of fisetin, glycine, hyaluronic acid, and more, uncovering how these ingredients contribute to longevity and overall health. 

Chris also shares insights into his daily health regimen, the clinical trials backing Novos' products, and the innovative formulations that are paving the way for a longer, healthier life. 

Tune in to discover how you can take control of your aging process and optimize your health with the latest in anti-aging science.

- visit https://novoslabs.com/

- Follow Chris @slowmyage

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/

Love is in the air as we dive into the science behind relationships.

In this episode, we explore the fascinating world of oxytocin, affectionately known as the "love hormone," and its connection to the OXTR gene.

Responsible for encoding the oxytocin receptor, this gene plays a crucial role in shaping our social bonds, empathy levels, and even cognitive abilities. We discuss groundbreaking research, including the 'happy marriage study,' which unveils intriguing insights into how our genetic variations may influence our relationship dynamics.

We uncover how oxytocin, influenced by the OXTR gene, extends beyond social bonding, playing a pivotal role in enhancing cognitive functions. Could our brain development be intricately tied to our social interactions?

Join us on this journey through the science of love and genetics.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. 

Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. 

The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging. 

Amitay also delves into the science of skin renewal, the role of vitamins and metabolites in skin health, and offers practical advice on creating an effective skincare regimen tailored to individual needs and skin types.

- Use code “SELFDECODE” for 10% off younggoose.com

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions.

Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. 

Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a night owl, as well as its influence on sleep disorders and mood.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine.

Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. 

Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels.

They provide invaluable insights into personalized supplements tailored to address individual genetic predispositions and health needs.

Explore the latest advancements in methylation and homocysteine management, and discover actionable strategies for promoting longevity and optimal well being.

- Visit @drbenlynch on Instagram

- Use code "SelfDecode10" to get 10% off seekinghealth.com 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Timestamps:

(0:00) - Intro

(1:09) - State of the genetics industry

(20:07) - MTHFR and methylation

(1:04:59) - Is overmethylating real?

(1:12:06) - Riboflavin and other B vitamins

(1:18:06) - How many supplements does Ben take a day?

(1:31:54) - Epigenetics and other alternative tests

In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. 

But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? 

We uncover the research behind this startling revelation and discuss the implications for our health and well-being. 

Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better longevity. 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. 

Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. 

From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more.

Michael shares some practical strategies for enhancing gut health and addressing chronic conditions.

Join Joe and Michael as they explore the pivotal role of lifestyle changes, targeted supplements, and personalized DNA data in achieving optimal well-being.

- Learn more about Michael’s practice at https://www.planetnaturopath.com/

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Michael Smith

(01:51) - Michael's process with patients

(10:34) - Important health data points

(19:21) - Looking at gut health

(27:35) - Food sensitivities and gut health

(32:56) - Other alternative markers and tests

(38:44) - Going through test results

Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness.

These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is your gateway to the best health advice we've uncovered in Season 5.

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Intro

(0:16) - Oz Garcia

(8:31) - Methylation

(17:44) - Michael Lustgarten

(24:26) - Optimal Lab Levels

(29:37) - Matt Kaeberlein

(46:34) - Immune System

Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness. 

Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component!

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we focus on the FTO gene's pivotal role in fat metabolism, appetite, and weight management. 

Get an in-depth analysis of how the FTO gene not only influences body weight and obesity risk but also regulates appetite and fat metabolism, alongside managing emotional eating and hunger levels. 

We discuss the gene's connection to weight-related challenges, including its effects on insulin resistance, blood sugar levels, and energy expenditure. 

By understanding one’s genetic predispositions, individuals can adopt personalized approaches to diet, lifestyle, and supplementation, turning genetic insights into actionable plans for improving fat metabolism and achieving weight management goals. 

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan.

Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin's effects, the best way to take it, and its impact on immune system processes.

Gain insights from Dr. Kaeberlein's research on the mTor mechanism and rapamycin, uncovering their promising potential in extending healthspan and enhancing lifespan.

Finally, Matt and Joe discuss aging clocks, biomarkers, and microbiome tests, evaluating their significance in the context of aging research and longevity enhancement.

- Visit https://www.optispan.life/

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Intro

(02:24) - Rapamycin overview

(22:04) - How Matt uses Rapamycin

(33:24) - Biomarkers affected by rapamycin

(37:33) -  Microbiome and aging clocks

(01:04:07) - How much can you maximize life span

In this episode, Dr. Maloof reveals her biohacking strategies to revolutionize your sex life, just as you would your nutrition and fitness.

Discover research-backed practices and expert insights that go beyond the basics, helping you elevate your intimate experiences and achieve a healthier, more fulfilling life.

As the founder and CEO of Adamo Bioscience, Molly is at the forefront of bringing modern sex education to couples with a groundbreaking intimacy program developed through a study of the science of love.

The Adamo Method is a 9-week program meticulously crafted for couples ready to propel their

relationship to extraordinary heights. 

Developed by relationship and sexuality experts Dr. Saida Desilets and Aaron Michael, The Adamo Method distills over 48 years of wisdom in the realms of sex, love, and human connection.

The Adamo Method has demonstrated statistically significant improvements in:

• Sexual Satisfaction: 86% of participants reported improvements.

• Sexual Communication: 79% of participants reported enhanced communication.

• Arousal: 73% of women reported improvements.

• Sexual Functioning: 67% of women reported enhancements.

• Orgasm Quality: 70.4% of women and 65.4% of men reported improved orgasm quality.

• Orgasm Frequency: 63% of women and 69.2% of men reported increased orgasm frequency.

• Reduction in Sexual Shame: Participants experienced a significant decrease in shame,

• promoting a healthier, more positive sexual self-image.

Note: these percentages refers to individuals who completed the program, and do not represent improvements at a population level.

Use code JOE10 and get 10% OFF Adamo

- visit https://livingadamo.com/

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/

Dive into the world of lab testing and unlock the secrets to optimal health.

In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine. 

Delve deep into the realm of comprehensive testing as Joe shares his insights on a variety of essential lab markers, including Complete Metabolic Panel, Complete Blood Count, Thyroid Panel, and Amino Acid Panel, among others. 

Learn why these tests are vital for gaining a holistic view of your well-being.

Discover common misconceptions surrounding lab tests and explore the benefits of leveraging advanced tools like SelfDecode for managing and analyzing your lab results effectively. 

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Intro

(0:40) - Mistakes people make when taking lab tests

(5:06) - Important lab tests

(11:34) - My journey with labs

(14:55) - The lab tests I take every quarter

We unravel the intricate relationship between sunlight, Vitamin D, and your genetic makeup, as we explore the pivotal role of Vitamin D in optimizing health and well-being.

At the heart of this discussion lies the VDR gene, a genetic blueprint responsible for producing the Vitamin D receptor, as we uncover it’s role alongside Vitamin D in the body.

We delve into the fascinating journey of Vitamin D synthesis, from sun-kissed skin to the activation of calcitriol, the biologically active form of Vitamin D. 

Understanding your unique genetic profile empowers you to make informed decisions about your health, from tailored dietary adjustments to personalized supplement strategies. So, join us on this genetic exploration and unlock the secrets of optimal health.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger. 

James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life.

Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health. 

- Use code “SELFDECODE” to get 15% OFF any product at neurohacker.com

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

Timestamps:

(0:00) - Intro

(1:28) - Jame’s first supplements and approach

(8:24) - Energy and mental clarity

(13:11) - Putting health into your own hands

(19:55) - Studies on Lyme Disease

(22:47) - Trusting your intuition vs a data driven approach

(30:17) - Exercise

(37:22) - Taking too many supplements

(45:29) - The one lab marker always affected by infection

(52:48) - Collagen and joint

(59:02) - NAD

(1:09:30) - Different Qualia Products

(1:11:25) - Unique biohacks

Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role.

In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger. 

Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections.

But the story doesn't end there – we explore other variants like rs1800796, connecting genetic makeup to conditions like acne, longevity, muscle recovery, and inflammatory diseases.

Is your IL6 gene making you ill, or is it your genetic strength?

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ 

Unlock the secrets to longevity with our deep dive into biohacking, lab tests, and supplements! In this episode, we explore the crucial role of lab markers in longevity, optimal lab test ranges, and associations that impact aging. Dive into the world of supplements, addressing concerns about tolerance and when is the right time to supplement for lifespan. Joe and Michael discuss the Dunedin Pace Test and its significance in aging, while shedding light on the impact of lifestyle changes and immune system health. Going deeper into the science, Michael and Joe analyze mortality risk, liver damage, protein intake, urea lives, fiber intake, calorie restriction and so much more on biological aging.Join us on this journey of discovery, as we discuss data points, close with valuable insights, and chart our future plans for further exploration into the fascinating world of longevity.

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

- Visit Conquer Aging or Die Trying!

Timestamps:

(0:00) - Introduction

(2:54) - How many supplements does Michael take?

(11:44) - Red blood cells

(14:47) - Can you increase longevity with no supplements?

(29:36) -  Dunedin Pace

(37:28) - Longevity based lab markers

(40:06) - The immune system

(42:36) - Labs affected by too much supplementing

(57:00) - Testosterone and LDL

(1:01:39) - New study on aging

(1:08:09) - Protein and amino acids

(1:13:30) - Urea and protein

(1:18:30) - Body fat and BMI

(1:23:57) - Supplementing vs training

(1:30:23) - Michael’s current diet

(1:33:34) - Michael’s current work

(1:47:17) - Urea and Uric Acid

(1:53:31) - Caloric restriction and longevity

This episode explores the transformative potential of the UGT1A1 gene in your body’s ability to detox toxins.

Uncover the role of this gene in Glucuronidation, a crucial chemical reaction that enhances the body's ability to detoxify.

Learn about the impact of genetic variations which can reduce the activity of the UGT enzyme, hindering the body's detox capabilities. Discover practical solutions to counteract toxic buildup and support the body's natural detoxification processes.

This episode unveils the science behind genetic detoxification, providing valuable insights into personalized approaches for optimal health.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: ⁠https://selfdecode.com/⁠

- Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠