OnAir, with Clinical Respiratory News – Details, episodes & analysis

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OnAir, with Clinical Respiratory News

Clinical Respiratory News

Health & Fitness

Frequency: 1 episode/33d. Total Eps: 17

Listen to OnAir with Clinical Respiratory News, the podcast about respiratory care and sleep-disordered breathing. In each episode we’ll be airing our thoughts on the latest research, trends and events in COPD and OSA, NIV and HFT, digital health and new technologies. Join our presenters as they interview clinical experts and bring you lively discussions and thought-provoking insights on recent studies and hot topics. Make sure you make time for OnAir! This content is intended for health professionals only. © ResMed

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https://thorax.bmj.com/content/77/2/178
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https://clinicaltrials.gov/study/NCT02835638
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How can we reduce the burden of COPD?

Episode 17

Friday, November 15, 2024 • Duration 21:01

Recorded to raise awareness on World COPD Day 2024, this episode of OnAir is dedicated to chronic obstructive pulmonary disease – the third-leading cause of deaths worldwide. But as well as discussing the prevalence, underlying causes and trajectories of the condition, expert guests Professor Jean-Louis Pépin and research scientist Elroy Boers share new perspectives provided by their recent findings on the subject, including:

How real-world evidence can better reflect the complexity and heterogeneity of COPD
Why analysing data on gender and socioeconomic differences can lead to greater understanding of the disease landscape
What real-word evidence tells us about treating COPD patients with NIV

Looking to the future, our guests finish on a positive note by discussing the potential beneficial impacts new COPD management strategies could have on patient outcomes and economic and healthcare burdens.

Guests:

Prof. Jean-Louis Pépin, PU-PH in Clinical Physiology, head of the HP2 research laboratory, Grenoble, France

Dr Elroy Boers, Lead Health Research Scientist, ResMed

Hosts:

Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care.

Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.

References and useful links:

Boers, M. Barrett, J.G. Su, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open. 2023;6(12):e2346598. doi:10.1001/jamanetworkopen.2023.46598
Boers, A. Allen, A. Benjafield, L.E. Crotty Alexander, A. Malhotra and M. Barrett. A scenario-based modeling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping. (abstract). ERS 2024.
-L Pépin, P. Lemeille, H. Denis, A. Josseran, F. Lavergne, A. Panes, S. Bailly, A. Palot, A. Prigent, Health trajectories before initiation of non-invasive ventilation for chronic obstructive pulmonary disease: a French nationwide database analysis, The Lancet Regional Health - Europe, 2023, 100717, ISSN 2666-7762, doi: 10.1016/j.lanepe.2023.100717. 2
J.-L. Pépin, E. Herquelot, H. Denis, A. Josseran, F. Lavergne, A. Schmidt, S. Bailly, A. Palot, A. Prigent, and on behalf of the MedXcloud group. Impact of Long-term Domiciliary Non Invasive Ventilation (NIV) on Severe Exacerbations and Survival in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Nationwide Cohort Study Using Multistate Models (abstract). Am J Respir Crit Care Med 2024;209:A4978.

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/.

This podcast is intended for healthcare professionals only.

Disclaimer:

This programme is non promotional and is sponsored by ResMed.
The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme.
The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits.

Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health.

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Exploring AI’s role in sleep and breathing health

Episode 16

Tuesday, October 22, 2024 • Duration 21:24

With 4,300 unique presentations from an estimated 30,000 authors at this year’s ERS, there was a lot of information to absorb… so we invited Dr Meredith Barrett, Vice President of Patient Health Insights at ResMed, who attended the event in Vienna, Austria, to share her highlights.

ERS’s theme was ‘Humans and Machines: Getting the Balance Right’ setting the scene for enthusiastic debate about artificial intelligence (AI) and what it means for the future of sleep and breathing health. Meredith distills the main talking points down into two key areas of insight:

Potential benefits of AI:

Increasing the accuracy of sleep-disordered breathing diagnostics
Analysing predictive factors for chronic conditions such as COPD and asthma
Detecting patterns in patient data to help personalise care
Improving efficiency and reducing workload for healthcare professionals

Questions and concerns about AI:

Whether it could undermine the patient-clinician relationship
The need for research on safety and effectiveness in real-world settings
Ethical questions, such as whether AI could cause biased outcomes
How patient data is handled and accessed

As well as exploring these topics with host Daniela Gautschi, Meredith tells us about other aspects of the agenda that caught her attention – with a focus on digital health, novel diagnostics in sleep, understanding the future burden of respiratory disease, and how to promote treatment adherence by understanding a user’s social context.

Guest:

Dr Meredith Barrett, Vice President, Patient Health Insights, ResMed

Host:

References and useful links:

Women and OSA: Breaking barriers to diagnosis and treatment

Episode 15

Monday, September 2, 2024 • Duration 49:30

While research has shown that women who are diagnosed and treated for OSA may experience greater improvements in quality of life scores and higher CPAP usage than men1, actually getting a diagnosis in the first place can be an uphill struggle.

So in this episode of OnAir we invite two leading experts on the topic, Prof. Sophia Schiza and Dr Alison Wimms, to explain why this is – and what can be done so more women with OSA can enjoy the benefits of therapy sooner and for longer...

They have a lot to say on the subject, so we’ve divided up the recording by questions, so you can focus on the areas that interest you the most, or listen to it as a whole – the choice is yours!:

Introduction

00:51 Schiza: Why is this an important topic?
03:09 Dr Wimms: What has kept you interested in this topic?

Differences between OSA presentation in men and women

05:02 What are the main symptoms of OSA for male and female patients?
09:06 How can we see differences in patients’ diagnostic traces?
11:51 Why do these differences exist?
11:06 Are there also difference between the sexes when it comes to treatment acceptance and response?
21:25 Are there any other differences to highlight?

Deep dive into female OSA research

27:25 Tell us more about the UK MERGE-data for mild OSA1...
33:54 ...and the ESADA-publication2 about OSA phenotypes where gender is one of the parameters of weight in the spider charts displaying patient characteristics?

Conclusion

43:31 What is the most important practical advice for clinicians who see women every day and want to help those with sleep apnoea?

Guests:

Prof. Sophia Schiza, Head of the ERS Assembly 4 Sleep Disordered Breathing and head of Sleep Disorders Center, Department of Respiratory Medicine at the School of Medicine, University of Crete, Greece

Home high-flow therapy: the Danish approach

Episode 14

Tuesday, August 6, 2024 • Duration 23:11

In this episode of OnAir Professor Ulla Møller Weinreich, Head of the Danish Lung Society, explains the why, who and how of the national guidelines for home HFT her team created in 20191, including:

Why they started using home HFT and the clinical benefits they discovered, including reduced dyspnoea, easier work of breathing and improved mucus clearance, 2 and cost-effectiveness of the treatment.3
Which patients benefit the most from the treatment – and how it can ease some of the physiological strains experienced by those with COPD or bronchiectasis.
How clinicians can initiate HFT with patients, starting by defining clear indications and treatment goals, before moving on to practical considerations such as setting the right flow and choosing the right cannula.

Guest:

Professor Ulla Møller Weinreich - Head of the Respiratory Research Unit, Aalborg University Hospital, Denmark, and Head of the Danish Lung Society

Host:

References and useful links:

Storgaard LH, Hockey H, Laursen BS, Weinreich UM. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018;13:1195-1205. https://doi.org/10.2147/COPD.S159666
Weinreich, U. M., Juhl, K. S., Søby Christophersen, M., Gundestrup, S., Hanifa, M. A., Jensen, K., … Storgaard, L. H. (2023). The Danish respiratory society guideline for long-term high flow nasal cannula treatment, with or without supplementary oxygen. European Clinical Respiratory Journal, 10(1). https://doi.org/10.1080/20018525.2023.2178600
Sørensen SS, Storgaard LH, Weinreich UM. Cost-Effectiveness of Domiciliary High Flow Nasal Cannula Treatment in COPD Patients with Chronic Respiratory Failure. Clinicoecon Outcomes Res. 2021;13:553-564

ASV: using real-world evidence for real-life insights

Episode 13

Tuesday, July 9, 2024 • Duration 21:56

In this episode of OnAir, host Daniela Gautschi is joined by two experts in ASV therapy* and real-world evidence: Prof. Michael Arzt (READ-ASV registry1, 2) and Prof. Renaud Tamisier (FACE-cohort3, 4 and FACIL-VAA5 registries).

Experience shows that ASV can improve symptoms and quality of life for some patients with central sleep apnoea. But which patients are most likely to benefit and why? By performing large-scale database analyses, Prof. Arzt and Prof. Tamisier have been able to identify clinically meaningful clusters of CSA patients, explore phenotypes that have yet to be studied by RCTs, and shed light on the critical role played by sleep, respiratory and cardiovascular comorbidities.

Listen now to understand how this research could transform the diagnosis, treatment and prognosis of patients with persistent CSA and Treatment-Emergent CSA.

Guests:

Prof. Michael Arzt - Professor of Internal Medicine, University Hospital Regensburg, Germany

Prof. Renaud Tamisier - Professor of Clinical Physiology, Grenoble Alpes University and Director of the Sleep Exploration Centre, Grenoble Alpes University Hospital, France

Host:

References and useful links:

Arzt M, Munt O, Pépin J-L, et al. Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV): protocol and cohort profile. ERJ Open Res 2023; 9: 00618-2022 [DOI: https://doi.org/10.1183/23120541.00618-2022]
Arzt M, Munt O, Pépin JL, Heinzer R, Kübeck R, von Hehn U, Ehrsam-Tosi D, Benjafield AV, Woehrle H. Effects of Adaptive Servo-Ventilation on Quality of Life: The READ-ASV Registry. Ann Am Thorac Soc. 2024 Jan 19. doi:

ATS 2024: a look to the future of sleep and breathing health

Episode 12

Monday, June 10, 2024 • Duration 14:46

The ATS (American Thoracic Society) International Conference is a key event in the global sleep and breathing health calendar. So in this episode of OnAir, we asked Kimberly Sterling and Luciana Rabello – who were there as part of ResMed’s Medical Affairs Team – to share the exciting developments and research findings that caught their attention.

Topics discussed include:

Endotypes: what they are and how they differ to phenotypes – with a look at the role endotyping can play in the management of heterogenous conditions like OSA, and why a collaborative approach to its application may be key.
AI in medicine: how large-language models ‘think’ about complex care cases compared to the reasoning of seasoned clinicians, and the possibility of developing speech-based screening for sleep apnoea.
GLP-1s: could the use of these anti-obesity medications be associated with increased PAP adherence?

Kimberly and Luciana also tell us about connecting with peers to share scientific findings from the 26 abstracts ResMed supported at the event – including evidence that suggests PAP therapy reduces the risks of death and hospitalisation for patients with OSA.*

Guests:

Dr Kimberly Sterling - Vice President, Global Value & Access, Medical Affairs, ResMed

Dr Luciana Rabello - Director of Clinical Advocacy, Medical Affairs, ResMed

Host:

References and useful links:

ATS President’s Message
*A. Malhotra, J.-L. Pépin, P.A. Cistulli, A. Wimms, F. Lavergne, F.H. Sert Kuniyoshi, S.H. Munson, B. Schuler, S.R. Badikol, C. Wilson, L. Willes, C. Kelly, T. Kendzerska, D.A. Johnson, R. Heinzer, C.-H. Lee, A.V. Benjafield, and on behalf of the medXcloud group. All-cause Mortality in Obstructive Sleep Apnea: Systematic Literature Review Including Randomised Trials and Confounding Adjusted Non-randomised Controlled Studies and Meta-analysis of Positive Airway Pressure Treatment (abstract). Am J Respir Crit Care Med 2024;209:A4735.

The Sleep Revolution project – shaking up the future of sleep medicine

Episode 11

Thursday, May 23, 2024 • Duration 21:38

Funded by a 15 million-euro grant from the EU’s Horizon 2020 programme for health demographic change and wellbeing, the Sleep Revolution project is an ambitious one that aims to shake up current diagnostic methods for sleep-disordered breathing (SBD).

In this episode of OnAir, we talk to the head of the project, Professor Erna Sif Arnardóttir. She tells us how she believes strong collaboration between the project’s partners convinced the EU that the Sleep Revolution project could make real change, including:

Bringing advanced sleep diagnostics from the hospital into patient’s homes
Encouraging patients to participate in their own care with the help of technical solutions
Developing different personalised treatment options for patients with SDB
Creating a new European Sleep Questionnaire to help capture the whole sleep profile of a person for clinical and research purposes

Prof. Arnardóttir also shares her thoughts on topics such as the importance of multi-night diagnostics, whether AHI is sufficient as parameter to classify the severity of OSA, and how digital tools – such as apps and wearables – and cooperation between different entities could transform the future of sleep medicine.

Guest:

Prof. Erna Sif Arnardóttir - Director of the Reykjavik University Sleep Institute; Associate Professor at the Department of Engineering and Department of Computer Science at Reykjavik University, Iceland

Host:

References and useful links:

https://sleeprevolution.eu/en

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at .

Benefits of OSA patient phenotyping

Episode 10

Thursday, March 28, 2024 • Duration 18:35

In this episode of OnAir, sleep clinician Prof. Dr Manuel Sánchez-de-la-Torre and host Daniela Ehrsam-Tosi discuss the potential benefits of patient phenotyping for obstructive sleep apnoea.

Prof. Dr Sánchez-de-la-Torre explores why patient phenotyping can be relevant during diagnosis, for making effective treatment decisions, and during the follow-up stage. He highlights the role of patient phenotype in predicting responses and understanding neutral effects, with a particular focus on blood pressure and hypoxic burden. He also emphasises the value of telemedicine in promoting engagement and treatment adherence.

Listen to learn why progress in patient phenotyping could affect the way you treat and understand your OSA patients.

Guest:

Prof. Manuel Sánchez-de-la-Torre - University of Lleida, principal Investigator of the ‘Precision Medicine in Chronic Disease Group’ at the Biomedical Research Institute of Lleida, Spain.

Host:

Reference:

Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. JAMA. 2023;330(13):1255–1265. https://doi.org/10.1001/jama.2023.17465

This podcast is intended for healthcare professionals only.

Disclaimer:

World Sleep Day: improving health by improving sleep

Episode 9

Wednesday, March 13, 2024 • Duration 09:18

In this episode of OnAir, clinical expert Professor Christoph Schöbel and host Daniela Ehrsam-Tosi discuss sleep quality and sleep disorders.

There’s a growing awareness of the importance of sleep for our cardiovascular system and our general health and wellbeing. At the same time, our ability to get good sleep is increasingly challenged by everything from late-night scrolling to irregular work schedules, stress and anxiety. It’s thought that 10-30% of people worldwide suffer from insomnia1, not to mention other sleep disorders like OSA and restless leg syndrome.

In this context, which diagnostic and treatment pathways should we be prioritising? Should primary care screening programmes focus on sleep as well as diet and exercise? What benefits might digital technology have to offer? Professor Schöbel shares his thoughts on these points, as well as discussing the new European Insomnia Guideline2 and the challenges of treating COMISA (co-morbid insomnia and sleep apnoea).

Guest:

Prof. Christoph Schöbel - Professor of Sleep Medicine with a focus on Telemedicine, University Medicine of Essen, Germany

Host:

References and useful links:

1. Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016 Oct-Dec;5(4):780-784. https://10.4103/2249-4863.201153. PMID: 28348990; PMCID: PMC5353813.
2. Riemann, D., Espie, C. A., Altena, E., Arnardottir, E. S., Baglioni, C., Bassetti, C. L. A., Bastien, C., Berzina, N., Bjorvatn, B., Dikeos, D., Dolenc Groselj, L., Ellis, J. G., Garcia-Borreguero, D., Geoffroy, P. A., Gjerstad, M., Gonçalves, M., Hertenstein, E., Hoedlmoser, K., Hion, T., … Spiegelhalder, K. (2023). The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. Journal of Sleep Research, 32(6), e14035.

CPAP and cardiovascular risk: what’s the relationship?

Episode 8

Monday, January 15, 2024 • Duration 14:27

In this episode of OnAir, we ask whether treatment-adherent OSA patients could be lowering their cardiovascular risk while they sleep. Professor Frédéric Gagnadoux and host Nina Wiklund explore the design, results and implications of his recent 5,000-patient cohort study, which indicates that CPAP can deliver a significant reduction in major adverse cardiovascular events. They ask which patients are likely to benefit, discuss the importance of hours of usage, and consider the tools that clinicians can use to support therapy adherence. Listen to learn about the potential impact of CPAP therapy on the cardiovascular health of your OSA patients.

Guest:

Prof. Frédéric Gagnadoux - Head of the department of respiratory and sleep medicine, University Hospital of Angers, France.

Host:

References and useful links:

Gerves-Pinquie C, Bailly S, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, et al.; Pays de la Loire Sleep Cohort Study Group. (2022). Positive airway pressure adherence, mortality and cardiovascular events in sleep apnea patients. Am J Respir Crit Care Med, 206, pp. 1393–1404. DOI: 1164/rccm.202202-0366OC
Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. 2023;330(13):1255–1265. doi:10.1001/jama.2023.17465
ERS 2023 Workshop: CPAP therapy and cardiovascular outcomes – what have we learned from real-life cohorts?

The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at .

OnAir, with Clinical Respiratory News – Details, episodes & analysis

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OnAir, with Clinical Respiratory News – Details, episodes & analysis

Podcast details

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