Microbiome Medics – Details, episodes & analysis

Dr. Siobhan McCormack interviews James Kinross, a colorectal surgeon and microbiome researcher. James discusses the potential of robotic surgery and its precision, the link between the microbiome and colorectal cancer, and the importance of preserving gut health. They explore probiotics, evidence-based treatments, and the role of Fusobacterium nucleatum in colorectal cancer. James emphasizes the need for microbial conservation for disease prevention and offers practical advice from his book "Dark Matter" on diet and nutrition for a healthier gut microbiome. This conversation highlights the critical impact of microbiome research on the future of healthcare.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Dr. Siobhan McCormack, Dr. Sheena Fraser, and guest Lucy Kerrison (aka The GutNut Dietician) discuss the role of diet in managing inflammatory bowel disease (IBD), focusing on Crohn's disease. Lucy emphasizes personalized nutrition, debunks dietary myths during flare-ups, and addresses challenges accessing dietitians in the NHS. The conversation covers low fiber diets, the Crohn's disease exclusion diet, essential nutrients in IBD management, fermented foods, Small Intestinal Bacterial Overgrowth (SIBO), and the low FODMAP diet. They advocate for tailored dietary advice, highlight the scarcity of dietitians for effective gut health management, and stress the importance of updated guidelines and holistic approaches in tackling gut-related conditions.

Patient resources

• https://crohnsandcolitis.org.uk 
• https://gutscharity.org.uk 
• https://www.bda.uk.com
• https://www.alandesmond.com/revolution

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this 3rd & final episode Dr Sheena & Dr Shiv get to chat to Professor Robert Thomas , a full time NHS Consultant Oncologist, Sorts and Nutrition scientist and active medical researcher who explains why he thinks the gut microbiome and gut health are key to cancer prevention, response cancer therapies and survivorship.

They discuss diet, research and patient empowerment. It seems that small, simple , achievable dietary and behaviour changes really can improve outcomes , overall wellbeing and survivorship. 

Professor Thomas Bio
Professor Robert Thomas is a full time NHS Consultant Oncologist at Bedford and Addenbrooke's Hospitals, a teacher at Cambridge University and visiting Professor of Sports and nutritional science at the University of Bedfordshire. He trained at the Royal Marsden Hospital had period of full-time laboratory and clinical research at the Institute of Cancer and Duke University, North Carolina. He now manages patients with chemotherapy, radiotherapy, hormones and biological targeted treatments but incorporates nutritional and lifestyle strategies to enhance their effect, reduce side effects and improve overall wellbeing.

He is also head of a Lifestyle and Cancer Research Unit which designs and conducts government backed studies evaluating the impact of exercise, diet and natural therapies on cancer, other chronic diseases and more recently recovery from Covid-19. In collaboration with Universities in Southern California, Cambridge and Glasgow, this unit has published over 100 peer reviewed scientific papers and regularly presents studies across the World. He is a patron of two cancer support charities and advises
Macmillan and other support groups on their informal materials for patients.

He previously led the UK Polybalm and Pomi-T randomised studies and currently leads the UK's covid-19 nutritional intervention study (The Phyto-V study) assessing whether prebiotic polyphenol rich foods plus a probiotic could lower the severity and duration of symptoms.

He is author of the UK bestseller "How to Live" and has been awarded The British Oncology Association “Oncologist of the Year” and The Royal College of Radiologist Research Medal.

Twitter: @cancernetUK
Facebook: @cancernetUK

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this 2nd episode on cancer and the gut microbiome , our Microbiome Medics duo continue their exploration of the impact of the gut microbiome on all aspects of cancer biology focusing on responses to cancer therapies and the potential effects of medications such as antibiotics and proton pump inhibitors on the resident microbes.

Dr Sheena discusses practical advice to improve gut health that she discusses with her NHS patients diagnosed with cancer and Dr Shiv introduces a few new concepts including the Oestrobolome and its importance to breast cancer and discusses a paper describing microbiomes within several different types of human cancers which may help further understanding of the impact of microorganisms on the hallmarks of cancer.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In the UK someone is diagnosed with cancer every two minutes. Every 4 minutes, someone dies of cancer. Startling statistics indeed, but did you know that human microbiomes, and the gut microbiome in particular, is pivotal to every aspect of cancer prevention, treatment response ,recovery and survivorship?

Given the importance of the subject, your loyal microbiome nerds, Dr Sheena and Dr Shiv, have chosen to allocate not one , not two, but three episodes of Microbiome Medics Podcast to this rapidly evolving and complex area of research.

In this first episode they get down and dirty with a cancer cell to figure out exactly how and why your resident gut micro-organisms might just be one of the most important resources you can utilise to harness the mighty power of your body’s remarkable and extensive anti-cancer systems. Dr Shiv thinks she can get you to fall in love with her favourite gut microbiome research paper and Dr Sheena gets all hot under the collar about the effect of sweeteners on gut microbiome function. Enjoy.

The paper discussed in this episode is:

O'Keefe SJ et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun. 2015 Apr 28;6:6342. doi: 10.1038/ncomms7342.

Chakalaka recipe link: https://www.wikihow.life/Make-Chakalaka

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Have you ever considered what difference infant feeding choice makes to long-term infant health? 

In this episode our two microbiome medics compare the impact of breast milk and formula milk on the developing infant gut microbiome. They  consider the rates of breast feeding in the UK and potential barriers to breast feeding, drawing on  their own experiences. Dr Shiv discusses a research paper from the USA  which looks at ‘re-wilding’ the infant gut microbiome with Bifidobacterium Infantis. 

The research paper discussed this episode:

O’Brien CE, Meier AK, Cernioglo K, Mitchell RD, Casaburi G, Frese SA, et al. Early probiotic supplementation with B. infantis in breastfed infants leads to persistent colonization at 1 year. Pediatr Res. 2022 Feb;91(3):627–36.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

You are 50% microbial by cell count, and your gut microbiome is central to all aspects of your physiology and health. The Microbiome Medics think you should know where the trillions of bacteria living in your intestines come from.

In this episode of Microbiome Medics, our microbiome obsessed duo discuss the importance of birth mode on gut microbiome acquisition. They highlight the massive increases in Caesarean section rates, and even chat about their own birth experiences. (Spoiler alert...it hurt)

Not to be missed by anyone born by vaginal delivery or caesarian section (or both).

That means you, by the way.  Get listening!

Discussed in this episode:

Korpela K, de Vos WM. Infant gut microbiota restoration: state of the art. Gut Microbes. 2022;14(1):2118811.
Shao Y et al. Stunted microbiota, and opportunistic pathogen colonization in caesarean section birth. Nature. 2019;574(7776):117–121.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

This week on the Microbiome Medics Podcast, Sheena and Siobhan are joined by fermentation expert - Janice Clyne. The team discuss the impact of fermented foods on the gut microbiome. Siobhan brings some interesting research comparing a fermented food diet to a high fibre diet and Janice shares a recipe with the listeners for a delicious and easy to make carrot kraut.
 
This week's paper is:
Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, et al. Gut-microbiota-targeted diets modulate human immune status. Cell [Internet]. 2021 Aug 5;184(16):4137-4153.e14. Available from: https://doi.org/10.1016/j.cell.2021.06.019

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this month's episode of Microbiome Medics - Siobhan and Sheena discuss "leaky gut". The controversy around this condition and the evidence of its existence and link with disease. A paper on emulsifiers is discussed in the research section. 

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this episode Siobhan and Sheena introduce you to the gut microbiome and discuss how it influences our health. They also consider how this knowledge has changed their own clinical practice. A recent research article on pain and the gut microbiome is discussed followed by a question and answer section. 

Reference

Nociceptor neurones direct goblet cells via a CGRP-RAMP1 axis to drive mucous production and gut barrier protection. Draping Yung et Al; Cell Oct 27 2022; article 1, Vol 185, ISS 22, p 4190-4205

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.