Your hormones control everything—from energy levels to weight, mood, and overall health. But understanding them shouldn’t feel like decoding a medical textbook. Welcome to Hormones, Metabolism & You!, the podcast where board-certified endocrinologist Dr. Cassie Smith breaks down the science behind your body’s most powerful regulators.
Each week, Dr. Smith tackles the real questions about metabolism, weight management, thyroid health, menopause, PCOS, insulin resistance, and more—giving you clear, actionable insights to take charge of your health. Whether you’re struggling with stubborn weight, feeling fatigued, or just want to optimize your well-being, this podcast is your go-to resource for evidence-based advice, practical tips, and expert interviews.
It’s time to understand your hormones, master your metabolism, and feel your best—because when your body is in balance, you thrive!
🎧 Subscribe now and start your journey to better health!
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48: The Truth About Supplements for Hormonal Health with Shawn Wells
Sunday, March 2, 2025 • Duration 01:11:10
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About Sean Wells: Shawn Wells, MPH, RD, CISSN, FISSN, is a globally recognized nutritional biochemist, dietitian, and supplement formulator. Known as The World's Greatest Formulator, he has developed over 1,000 products and holds 40+ patents in the health and wellness industry.
A best-selling author of The ENERGY Formula, Shawn’s work has been featured on major platforms like Forbes, NPR, and The Joe Rogan Experience. Passionate about optimizing health, he continues to innovate in performance nutrition and longevity.
Hormonal Health & Menopause Support
Evening Primrose Oil – Supports hormonal balance and reduces hot flashes
Borage Oil (High GLA Source) – Supports menopause symptoms and skin health
Dong Quai – Traditional herb for hormonal balance
Maca Root – Enhances libido and energy
Pregnenolone – A precursor hormone for estrogen, progesterone, and DHEA
Stress & Adaptogens
Ashwagandha – Reduces cortisol and supports stress resilience
Rhodiola Rosea – Enhances mental and physical performance
Holy Basil (Tulsi) – Reduces anxiety and promotes relaxation
L-Theanine – Supports focus and relaxation without drowsiness
Sleep Optimization
Magnesium Glycinate – Supports relaxation and muscle recovery
Melatonin (Low Dose) – Supports circadian rhythm and deep sleep
Glycine – Improves sleep quality and cognitive function
Gut & Metabolic Health
Tributyrin (Postbiotic) – Supports gut lining integrity
Berberine (Dihydroberberine) – Supports insulin sensitivity and metabolic health
Vitamin D3 – Essential for immune function and hormone balance
Methylated B Vitamins (B6, B12, Folate) – Supports mood, energy, and cognitive function
Cognitive & Mood Support
SAM-e – Supports mood and neurotransmitter balance
5-HTP – Precursor to serotonin for mood and sleep support [add link]
Alpha-GPC – Boosts cognitive function and memory [add link]
Methylene Blue – Enhances mitochondrial energy production [add link]
Libido & Sexual Health
Horny Goat Weed (Icariin) – Enhances blood flow and testosterone availability
Nitric Oxide Boosters (Beetroot, Citrulline, Arginine) – Supports circulation and sexual function
📚 More From Shawn Wells
Visit ShawnWells.com for more insights
Follow Shawn on Instagram: @ShawnWells
Read The ENERGY Formula
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
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47: Is Your Lack of Sleep Making You Fat? with Dr. Audrey Wells
Episode 47
Sunday, February 23, 2025 • Duration 55:48
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TL;DR: In this episode of "Hormones, Metabolism, and You," Dr. Cassie Smith, who specializes in functional medicine and endocrinology, teams up with Dr. Audrey Wells, an expert in sleep medicine, to delve into how sleep significantly influences mental health. They talk about how common sleep disorders are in the U.S., affecting between 50 to 70 million people, and how these disorders can contribute to anxiety and depression. The episode also touches on how much sleep we really need, the limitations of using sleep tracking devices, and the particular sleep issues that women often face. Dr. Wells stresses the importance of maintaining good sleep habits and shares practical tips for getting better sleep. She also points out the necessity of taking a comprehensive approach when diagnosing and treating sleep disorders.
About Dr. Audrey Wells:
Audrey Wells, MD attended University of Michigan Medical School and went on to train at Washington University School of Medicine in pediatrics and pediatric pulmonary medicine. It was during this time that she developed a specific interest in adult and pediatric sleep medicine. She returned to her home state of New Mexico to complete a sleep medicine fellowship. As Chief Medical Officer, she led the development of OmniSleep Medicine Centers to become a comprehensive sleep clinic for both adults and children from 2010 to 2018.
Show Highlights:
(00:00:06) Dr. Cassie Smith introduces the podcast and highlights the significance of sleep disorders affecting many Americans.
(00:01:20) How sleep issues relate to mental health disorders like anxiety and depression.
(00:02:09) Understanding how much sleep individuals need, varying by sex and personal circumstances.
(00:03:10) Symptoms and signs indicating potential sleep problems, including feedback from sleep partners.
(00:07:31) Discussion of how sleep deprivation can exacerbate symptoms of anxiety, depression, and ADHD.
(00:18:36) Impact of hormonal changes during menstruation, pregnancy, and menopause on sleep quality.
(30:04) Exploration of how alcohol consumption negatively impacts sleep and heart rate variability.
(32:44) Strategies to improve sleep quality, including managing negative thoughts and creating a calming environment.
(40:43) Connection between sleep deprivation and emotional dysregulation, emphasizing the importance of adequate sleep for mental health.
(00:49:10) How sleep deprivation affects healthcare professionals' performance and well-being.
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Dr. Audrey Wells:
Super Sleep MD Website
A. Wells MD, The Expert Sleep Coach Website
Instagram (@supersleepmd)
Facebook Group: Super Sleep MD – A CPAP and Sleep Apnea Community
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Episode 38: Redefining The Definition Of “Diet” & Strength Training For Women with Sal Di Stefano, Mind Pump Host
Episode 38
Sunday, December 22, 2024 • Duration 01:21:47
About My Guest:
Sal Di Stefano is a fitness expert, entrepreneur, and co-host of the Mind Pump podcast. With over two decades of experience in personal training and fitness education, Sal is passionate about busting myths in the health industry and promoting sustainable, science-backed approaches to fitness. His expertise lies in helping people build muscle, improve metabolism, and develop healthy relationships with exercise and nutrition.
Social Handles:
Website
Facebook
Instagram
YouTube
Summary:
This episode focuses on how women can revolutionize their fitness routines by incorporating strength training, eating whole foods, and aligning exercise with their body’s natural cycles. Sal shares practical advice for overcoming fitness myths and building sustainable health habits that prioritize well-being over aesthetics. With actionable tips for beginners and insights for seasoned fitness enthusiasts, this conversation is a must-listen for anyone looking to optimize their health.
Timestamps:
(00:00) Introduction to Sal Di Stefano and his journey into fitness
(05:28) The misconceptions women face in fitness
(11:14) Why strength training is key to long-term health
(17:55) The metabolic benefits of building muscle
(29:05) Overcoming fitness myths and establishing healthy routines
(43:55) Intuitive eating and avoiding processed foods
(57:45) The role of strength training in hormonal balance
(1:12:10) Final tips for sustainable health habits
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Disclaimer
Episode 37: The Mental Health, Insulin, and Gut Connection: How to Heal ADHD, Brain Fog, Anxiety, and Depression
Episode 37
Sunday, December 15, 2024 • Duration 01:22:55
About My Guest:
Dr. Matt Bernstein is one of the leading voices in the emerging field of metabolic psychiatry. He trained as a psychiatry resident in Belmont, Massachusetts, where he served as chief resident. He was also a psychiatrist in charge and later served as an assistant medical director of a schizophrenia and bipolar inpatient unit.
Dr. Bernstein developed his passion for community-based care as the chief medical officer of Ellenhorn, where he pursued alternative ways such as focusing on metabolism, nutrition, cardiac rhythm, biology, and exercise to help individuals achieve their best level of functioning without relying solely on traditional psychiatry approaches.
Social Handles:
Website
Facebook
LinkedIn
Summary:
Join me in this episode of the #BackToTheBasicsPodcast as we delve into the innovative approach of metabolic psychiatry with Dr. Matt Bernstein.
Drawing from years of experience and his groundbreaking work with ketogenic diets, he explains how addressing cerebral insulin resistance and improving mitochondrial function can significantly benefit patients with psychiatric disorders.
From anxiety and depression to schizophrenia and bipolar disorder, we shed light on how these conditions can be better managed or even mitigated through targeted dietary and lifestyle changes.
Timestamps:
08:57 - The impact of ketosis on mental health disorders
18:14 - What is the cell danger response?
24:10 - ADHD and its metabolic impact on children's behavior
30:51 - The link between childhood insulin resistance and mental illness
44:15 - The importance of exercise, sleep, and circadian rhythm for mental health
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Episode 36: Thyroid Truth: Iodine, Hashimoto's, and Hypothyroidism
Episode 36
Sunday, December 8, 2024 • Duration 47:49
About My Guest:
Dr. Alan Christianson, NMD is a board-certified naturopathic endocrinologist focused on thyroid care. He is also a best-selling author whose recent titles include The Thyroid Reset Diet and The Metabolism Reset Diet.
Dr. Christianson has been featured on countless media appearances including Dr. Oz, The Doctors, and The Today Show. He is the founding president behind the Endocrine Association of Naturopathic Physicians and The American College of Thyroidology.
Social Handles:
Website
Facebook
Instagram
Summary:
Discover the hidden link between iodine and thyroid health with Dr. Alan Christensen. In this episode of the #BackToTheBasicsPodcast, learn how environmental factors, diet, and genetics influence thyroid function. Debunk myths about iodine supplementation, understand the limitations of testing, and explore natural strategies to support thyroid healing.
Timestamps:
02:14 - Why thyroid disease rates are increasing.
06:59 - Debunking iodine myths: testing, supplementation, and risks.
18:04 - Managing iodine intake with dietary adjustments.
20:01 - Can Hashimoto's and hypothyroidism be reversed?
29:27 - Success stories of reversing thyroid issues.
40:11 - Benefits of morning sunlight and circadian rhythm resetting.
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Disclaimer
Episode 35: How Your Brain and Gut Shape Your Health and Mood
Episode 35
Sunday, December 1, 2024 • Duration 01:18:37
About My Guest:
Dr. Mark Gordon is the author of The Clinical Application of Interventional Medicine, which is recognized as a primer for the standards of care and assessment for interventional endocrinology. He is currently the medical director of CBS/Viacom Studios and the medical director of education for Assess Medical Laboratories. He has also participated in projects with HBO, ESPN, CNN, FOX, and Good Morning.
Social Handles:
Website
Instagram
Summary:
In this episode of the #BackToTheBasicsPodcast, let’s dive into the brain-gut connection with neuroendocrinologist Dr. Mark Gordon. Our discussion also reveals how inflammation impacts brain function, hormonal balance, and overall health, offering actionable insights into optimizing mental and physical wellness.
Timestamps:
04:12 - How trauma impacts hormones and the connection to depression
06:34 - The role of gut health in treating inflammation
14:50 - Peroxynitrite and its role in mood disorders
23:09 - Secondary hypothyroidism caused by brain inflammation
31:25 - Non-traumatic factors contributing to brain injuries and mental health issues
43:11 - Benefits of pregnenolone in addressing cognitive decline and hormonal imbalance
57:42 - The importance of optimized hormonal levels for reversing chronic conditions
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Disclaimer
Episode 34: The PCOS Puzzle: Mastering Metabolic Health with Marcelle Pick
Episode 34
Sunday, November 24, 2024 • Duration 01:00:29
About My Guest:
Marcelle Pick, OB-GYN NP, is a globally recognized women’s health expert, author, and educator. She co-founded the Women to Women Clinic in 1983 to transform how women experience healthcare. Marcelle’s Drop20 Now™ method has empowered thousands of women to achieve their weight loss and wellness goals naturally.
Social Handles:
Website
Facebook
Instagram
Summary:
Marcelle Pick explains how PCOS is often misunderstood as a hormonal disorder when it is fundamentally a metabolic issue. She shares actionable advice on improving diet, incorporating mindful exercise, and supporting adrenal health to overcome PCOS symptoms.
Timestamps:
(00:00) – Introduction and feedback on PCOS interest
(02:14) – Meet Marcelle Pick: her journey and expertise
(03:00) – Why PCOS is a metabolic problem
(05:33) – Practical dietary tips for PCOS management
(10:22) – Recognizing PCOS symptoms
(17:57) – Exercise and PCOS: What’s safe and effective
(26:55) – Carbs, protein, and timing in PCOS nutrition
(35:16) – The importance of listening to your body
(48:48) – Why gut health and adrenal function matter
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Episode 33: How Gut Health and Hormones Are Linked: Insights from Dr. Peter Kan
Episode 33
Sunday, November 17, 2024 • Duration 01:20:42
About My Guest:
Dr. Peter Kan is a board-certified integrative medicine practitioner, functional medicine expert, and chiropractic neurologist specializing in chronic conditions. He is the creator of the NeuroMetabolic Integration program and has helped over 5,000 patients worldwide reclaim their health through his virtual practice. Dr. Kan bridges Eastern and Western medicine, emphasizing the body’s innate ability to heal.
Social Handles:
Website
Instagram
LinkedIn
Summary:
This episode dives into the role of gut health in hormonal imbalances like PCOS. Dr. Kan explains how insulin resistance, neurological dysfunction, and gut microbiome imbalances create a cascade of health issues. He provides practical tips for improving digestion, reducing inflammation, and balancing hormones through lifestyle changes.
Timestamps:
(00:00) - Introduction: Why Gut Health is Crucial for PCOS and Hormonal Balance
(01:32) - What is a Chiropractic Neurologist? Understanding Functional Neurology
(03:32) - Nerves and Digestion: The Importance of the Vagus Nerve in Gut Health
(05:25) - Insulin Resistance and PCOS: How They Impact Neurology and the Gut
(13:48) - Signs of Poor Gut Health and How They Relate to Hormonal Imbalance
(21:41) - The Role of Muscle Mass in Insulin Resistance and Hormonal Health
(32:49) - How Stress and Sleep Affect Digestion, Hormones, and Overall Health
(37:36) - Alcohol’s Impact on Sleep, Gut Microbiome, and Hormonal Balance
(50:25) - Probiotics, Prebiotics, and Postbiotics: What You Need to Know
(59:23) - Mitigating Stress to Support Gut and Hormonal Health
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
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Episode 32: Mold, Gut Health, and DUTCH Testing with Aimee Neumann
Sunday, November 10, 2024 • Duration 01:20:27
About My Guest:
Aimee Neumann is a certified nurse practitioner with 17 years of experience specializing in women’s health and functional medicine. After overcoming a personal diagnosis of stage one breast cancer, Aimee has dedicated her career to uncovering the root causes of health issues, empowering her patients to achieve holistic wellness.
Social Handles:
Website
Instagram
LinkedIn
Summary:
Join Dr. Cassie Smith and Aimee Neumann as they explore the transformative power of gut health, advanced hormone testing, and mold toxicity awareness. This episode sheds light on the intricacies of DUTCH testing, the importance of gut health in hormone balance, and actionable ways to manage mold exposure. Perfect for anyone looking to take control of their health holistically!
Timestamps:
(00:00) Introduction and alarming stats about menopause and hormones.
(02:36) Why conventional training often overlooks hormonal health.
(06:46) The science behind DUTCH testing and how it works.
(09:16) Gut health’s impact on hormones and the estrobolome.
(37:09) The underestimated danger of mold toxicity and its symptoms.
(53:55) Testing for mold: urine vs. blood testing methods.
(1:07:21) Why investing in your health is key to true wellness.
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
Check out the website
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Disclaimer
Episode 31: Inside the World of Peptides: What You Need to Know for Better Health
Sunday, November 3, 2024 • Duration 01:05:11
If you are a provider and would like more education or information on the peptides we discussed in this podcast, here is a link to nucleus Pro:
https://nucleus.nubioage.com/checkout/nucleus-pro?via=cassie
If you are a provider and would like to sell any of the supplements we discussed in this podcast, here is a link to nuBioAge supplements:
https://affiliates.nubioage.com/register?ref=4NJv2kFPNW&p=136448
About My Guest:
Hayden Collier, PharmD is the director of clinical services at nuBioAge. He is committed to advancing healthcare through innovative, patient-centered approaches. With a passion for weightlifting, he draws parallels between the discipline of fitness and the importance of prevention in modern medicine. Hayden’s expertise extends beyond the pharmacy, blending sports science with cutting-edge medical strategies to redefine how we approach health and longevity. A dedicated husband, father, and sportsman, he brings the same focus and energy to both personal and professional life, always striving to inspire others to take charge of their well-being.
Social Handles:
Facebook
Instagram
NuBioAge
Instagram
Linkedin
Summary:
Join Dr. Cassie Smith and compounding pharmacy expert Hayden Collier, PharmD, as they dive into the world of peptide therapies, mitochondrial health, and what makes a quality compounding pharmacy.Timestamps:
00:00 - Introduction to Back to the Basics and Overview of Peptide Therapy
05:00 - Guest Introduction: Hayden Collier and the Role of Compounding Pharmacies
10:15 - Explanation of 503A vs. 503B Pharmacies and Regulation Differences
16:00 - Discussion on Mitochondrial Health and Benefits of Methylene Blue
21:00 - Addressing Risks of Buying Peptides Online Without Medical Supervision
27:30 - Overview of NAD Peptides and Their Role in Energy Production
34:00 - Importance of Gut Health and Introduction to Peptides for the Gut
41:00 - Thymosin Alpha and Beta: Uses in Autoimmune and Injury Recovery
47:00 - Hormone Health and Peptides for Sexual Health and Anti-Aging
54:00 - Closing Thoughts on Peptide Therapy’s Role in Holistic Health
💊 Get Dr. Cassie's own blend of Dynamic Vitamin D+K2 here: https://www.modern-endocrine.com/shop/#!/Dynamic-D-K2-60-Count/p/520045249/category=0
⚡️Get Dr. Cassie’s Iron Supplement here: https://www.modern-endocrine.com/shop/#!/Iron-60-CT-ME/p/520055514
🧪Get Dr. Cassie’s Mighty Methylfolate here: https://www.modern-endocrine.com/shop/#!/Mighty-Methylfolate-60-Count/p/520047649
Connect with Modern Endocrine:
Check out the website
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