Explore every episode of the podcast Hart2Heart with Dr. Mike Hart
| Title | Pub. Date | Duration | |
|---|---|---|---|
| #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price | 08 Oct 2026 | 01:25:18 | |
Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contamination, emergency-room strain, physician burnout, and broader problems within the Canadian healthcare system. They also examine medical cannabis, CBD and lesser-known cannabinoids, psychedelic medicine, sleep, longevity, and the importance of balancing individual choice with evidence, clinical judgment, and responsible medical guidance. Dr. Ira Price is an emergency physician, sports medicine specialist, and longtime cannabinoid-medicine practitioner whose work sits at the intersection of acute care, emerging therapeutics, and patient-centered medicine. Over nearly two decades working with cannabinoids and years on the front lines of emergency care, he has developed a strong focus on helping patients navigate treatments that often move faster than traditional medical guidelines. His approach emphasizes collaboration rather than gatekeeping, encouraging physicians to remain lifelong learners while helping patients critically evaluate evidence, understand risks and benefits, and make more informed decisions about their health. He brings a practical perspective shaped by emergency medicine, sports medicine, cannabinoid research and clinical practice, and firsthand experience with the evolving challenges facing modern healthcare.
Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer Related Pain — Li Wang et al., including Dr. Ira Price / The BMJ H2H 241 IRA PRICE TRANSCRIPT BMJ https://www.bmj.com/content/374/bmj.n1034 Therapeutic Potential of Cannabidiol (CBD) in Anxiety Disorders: A Systematic Review and Meta-Analysis — Kevin Han, Jia-Yu Wang, Peng-Yun Wang & Yue-Chu-Han Peng H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/38924898/ EPIDIOLEX (Cannabidiol) — Jazz Pharmaceuticals H2H 241 IRA PRICE TRANSCRIPT EPIDIOLEX.com https://www.epidiolex.com/what-is-epidiolex Acute Effects of Cannabigerol on Anxiety, Stress, and Mood — Carrie Cuttler, Amanda Stueber, Ziva D. Cooper & Ethan Russo / Scientific Reports H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/39003387/ CBD and THCV in Patients With Type 2 Diabetes — Khalid A. Jadoon et al. / Diabetes Care H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/27573936/ Dependence Potential and Acute Toxicity of Psychoactive Substances — Robert S. Gable / American Journal of Drug and Alcohol Abuse H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/8213692/ Tru Niagen / Nicotinamide Riboside (NR) — Niagen Bioscience / Dr. Charles Brenner H2H 241 IRA PRICE TRANSCRIPT Tru Niagen https://www.truniagen.com/pages/our-story Oura Ring Sleep Tracking — Oura Health H2H 241 IRA PRICE TRANSCRIPT Oura Support https://support.ouraring.com/hc/en-us/articles/11752397946003-Sleep-Stages
Show Notes 00:00 Welcome to the Hart2Heart Podcast 02:04 Peptides Are Everywhere 04:01 GLP-1s Disrupt Weight Loss 08:02 Metformin Longevity Debate 10:41 Doctors Handling Unapproved GLPs 17:17 Patient Power And Education 21:31 Misinformation And Collaboration 25:02 Canadian Drug Policy Overhaul 31:37 Fentanyl Lacing Medetomidine 36:23 Why Healthcare Is Failing 41:01 ER Burnout And Wellness 43:17 Physician Self Care 43:39 Residency Grind Reality 44:23 Fixing Resident Hours 45:34 ER Career Longevity 47:05 Private Healthcare Debate 51:07 Immigration System Strain 53:24 CBD Hype vs Evidence 56:53 CBD Dosing and Cost 01:00:39 Buspirone and Psychedelics 01:08:24 Underrated Cannabinoids 01:12:54 Cannabis Sleep and REM 01:19:03 Cannabis Risks and Alcohol 01:24:47 Closing Thoughts
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology | 01 Oct 2026 | 01:03:19 | |
Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving role of GLP-1 medications in obesity treatment and long-term cardiometabolic health. Dr. Spencer Nadolsky is a physician specializing in obesity medicine, lipidology, and cardiometabolic health, with a strong focus on preventing chronic disease before it develops. His approach combines evidence-based medicine with individualized risk assessment, helping patients make sense of cholesterol, metabolic health, body weight, medications, and lifestyle without relying on one-size-fits-all recommendations. Known for translating complex medical research into practical guidance, he emphasizes sustainable health decisions, meaningful clinical outcomes, and finding the balance between being proactive about longevity and becoming overly consumed by it.
SAMSON Trial: Statin, Placebo, and No Treatment — James P. Howard et al. / Imperial College London https://pubmed.ncbi.nlm.nih.gov/34531021/
Multi-Ethnic Study of Atherosclerosis (MESA) — National Heart, Lung, and Blood Institute / NIH https://www.nhlbi.nih.gov/science/multi-ethnic-study-atherosclerosis-mesa
Framingham Heart Study Offspring Cohort — National Heart, Lung, and Blood Institute / BioLINCC https://biolincc.nhlbi.nih.gov/studies/framoffspring/
Repatha (Evolocumab) — Amgen https://www.repatha.com/resources-and-support
Ezetimibe — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/ezetimibe-10mg-tablet/
Rosuvastatin — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/rosuvastatin-10mg-tablet/
Psyllium Fiber / Metamucil — Procter & Gamble / Metamucil https://www.metamucil.com/en-us/articles/psyllium-fiber/psyllium-fiber-in-metamucil
Docs Who Lift Podcast — Dr. Spencer Nadolsky & Dr. Karl Nadolsky https://docswholift.com/podcast/
Vineyard — Dr. Spencer Nadolsky
Dr. Spencer Nadolsky on Instagram — Dr. Spencer Nadolsky https://www.instagram.com/drnadolsky/
Dr. Spencer Nadolsky on X — Dr. Spencer Nadolsky
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:46 Why Switch To Repatha 02:42 Diet Limits And ApoB Goals 04:03 Ezetimibe And Statin Rationale 05:07 Family History Wake Up Call 06:26 Nocebo And Cleaner PCSK9 10:31 Lp Little A Not A Factor 11:47 Oura Ring And Biohacker Stress 13:33 Dropping Pitavastatin And CoQ10 17:20 Bempedoic Acid And Combo Therapy 20:18 LDL ApoB Discordance Explained 23:37 How Low Is Too Low 26:10 Optimal Targets And When To Start 29:13 Can Ultra Low Prevent Plaque 31:09 Why People Ignore Cholesterol 32:23 Can Plaque Regress 33:16 Vitamin K2 Reality Check 34:00 Mechanisms vs Outcomes 34:58 Lp(a) Drug Disappointment 37:08 How to Use Lp(a) 40:23 HDL Myths Explained 43:11 Triglycerides and Insulin 45:35 Oxidized LDL and NMR 47:33 Supplements That Matter 48:51 Berberine Benefits and Risks 51:50 GLP-1 Stacking Debate 56:41 Microdosing and Plateaus 59:34 Longevity and Alcohol Effects 01:00:36 Future of Anti Obesity Drugs 01:02:00 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #239 Oral Peptides: How They Work Without Entering the Bloodstream | 24 Sep 2026 | 00:20:28 | |
Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky.
LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati | 17 Sep 2026 | 01:09:46 | |
In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function.
Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge
Show Notes
00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening | 10 Sep 2026 | 01:25:22 | |
Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers. Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.
NOBS Toothpaste Tablets — NOBS NOBS Herbal Mouthwash — NOBS Atomic Habits — James Clear Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter Relative Dentin Abrasivity (RDA) Explained — American Dental Association
Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:08 Why Oral Health Matters 04:35 Choosing The Right Toothpaste 09:15 Why Whitening Toothpaste Fails 13:58 Key Toothpaste Ingredients 22:49 Hydroxyapatite And Fluoride 28:31 Electric Brushes And Technique 30:56 Waterpik Versus Flossing 34:32 Mouthwash Myths And Safer Picks 40:24 Acidic Mouthwash Risks 41:00 Tongue Scraping Basics 44:21 Nighttime Snacking Rules 45:48 Carbonated Drinks and pH 47:43 Mouth Breathing and Dry Mouth 50:39 Teeth Whitening Science 54:00 Whitening Options and Longevity 01:00:25 Dental Cleaning Ingredients 01:01:54 Fillings Materials and Safety 01:06:53 Root Canals Mythbusting 01:11:34 Veneers Hype and Downsides 01:16:37 Gum Disease and Heart Health 01:20:19 Ideal Oral Hygiene Plan 01:24:10 Where to Find NOBS
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims | 03 Sep 2026 | 01:24:55 | |
In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition offers, while Dr. Price separates what he has personally observed from what has yet to be established through rigorous research. The conversation explores cannabinoids, THC, CBD, terpenes, chemotherapy and radiation, pathology and imaging, the limitations of anecdotal evidence, and the regulatory, funding, and data-access barriers standing between individual case reports and credible clinical trials. Lee Whitley is an entrepreneur and the creator of Lee's Oil and Lee Helps, a cannabis-based project that grew out of his personal experience with cancer and his years of developing and refining a proprietary cannabis formulation. He has since become an outspoken advocate for studying the results he says he has observed through formal clinical research. Dr. Ira Price is a physician with nearly two decades of experience prescribing cannabinoids and researching medical cannabis, including published work on cannabis for opioid substitution and years of lecturing internationally on cannabinoid medicine. Together, Whitley and Dr. Price bring two very different perspectives to the conversation—one shaped by personal experience and unconventional experimentation, and the other by clinical practice, scientific skepticism, and a focus on evidence, regulation, and properly designed trials. Lee Helps / Lee's Oil — Lee Whitley Cannabis for Opioid Substitution Trial (COST) — Dr. Ira Price / Cannabis Research Associates https://clinicaltrials.gov/study/NCT03859089 Cannabis Research Licensing — Health Canada
Clinical Trials With Cannabis — Health Canada Human Health Therapeutics Research Centre — National Research Council Canada
Prescribing Drugs Policy — College of Physicians and Surgeons of Ontario (CPSO) https://www.cpso.on.ca/physicians/policies-guidance/policies/prescribing-drugs 4-Year-Old Cancer Case With 132 Tumors — Lee Whitley / Shit My Dad Taught Me Lee Helps Cancer & Melanoma Testimonials — Lee Whitley / Lee Helps Oil
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Claimed Cure Rates 01:59 Doctor Skepticism 03:47 Four Year Old Case 06:40 Colon Cancer Testimonial 09:43 Lee Cancer Story 14:28 Injection Timeline 16:00 Formula Breakdown 18:28 Terpenes Explained 21:29 Rick Simpson Comparison 24:52 How It Works 27:43 Chemo Radiation Debate 33:20 Injections Vs Pills 36:42 Research Roadblocks 44:03 Trial Plans Abroad 44:34 30 Women Trial Plan 46:02 Study Design Debate 47:23 Dosing Protocol Details 48:43 Big Pharma Buyout Claims 51:50 Suppression And Threats 55:12 What Happens After Success 57:59 Finding Patients And Reach 59:48 Treating More Than Cancer 01:06:51 How The Plant Was Found 01:13:47 Chemo Radiation Clash 01:17:59 Timeline And Publication 01:20:27 Closing Advice And Wrap
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #235 Dr. Leigh Erin Connealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors | 27 Aug 2026 | 01:06:14 | |
In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial function. They also discuss fasting and ketogenic diets, cancer screening, GLP-1 medications, aspirin, peptides, medicinal mushrooms, IV vitamin C, and other integrative approaches, along with Dr. Connealy's concerns about conventional screening and treatment practices. Throughout the conversation, she emphasizes individualized care and looking beyond a diagnosis to understand the broader conditions affecting each patient.
Dr. Leigh Erin Connealy is a medical doctor with four decades of experience who takes a prevention-focused, whole-person approach to health, longevity, and complex chronic disease. Her work spans human optimization through advanced conditions including cancer, dementia, autoimmune disease, and Parkinson's, with an emphasis on identifying and addressing factors that may interfere with the body's ability to function optimally. Her approach was shaped in part by her own health journey after learning that she had been exposed before birth to DES (diethylstilbestrol), which led her to undergo ongoing evaluations at MD Anderson and explore medicine beyond conventional symptom-based care. Over her career, she has incorporated individualized laboratory assessment, natural hormones, nutrition, peptides, and other integrative strategies while emphasizing what she describes as "creating health" rather than simply treating a diagnosis.
[The Cancer Revolution] — Leigh Erin Connealy, MD / Hachette Book Group [Be Perfectly Healthy] — Leigh Erin Connealy, MD / Perfectly Healthy [Celluverse Podcast] — Dr. Leigh Erin Connealy, Alannah Connealy & Jess Donovan [Dr. Leigh Erin Connealy Instagram — @connealymd] — Leigh Erin Connealy, MD [Cologuard Plus] — Exact Sciences Corporation [QTI Breast Acoustic CT Scanner] — QT Imaging Holdings, Inc. [UT MD Anderson Cancer Center] — The University of Texas MD Anderson Cancer Center [Eminence Organic Skin Care — Sun Care] — Eminence Organic Skin Care [Primally Pure Sunscreen] — Primally Pure [COOLA Sunscreen] — COOLA
Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:07 Root Cause Medicine 02:29 Is Cancer Preventable 05:42 Biggest Risk Factors 09:51 Toxins And Detox Testing 12:26 Sweating And Detox Baths 00:00 Doctors Not Listening 16:58 Does Sugar Feed Cancer 22:37 Fasting And Keto Strategies 26:05 Mushrooms And Supplements 27:21 Thiamine And Nutrient Gaps 29:35 Hormones And Cancer Risk 35:42 Complete Hormone Panels 38:02 GLP-1s and Cancer Risk 39:18 Daily Aspirin Debate 41:12 Peptides to Avoid 43:20 Russian Peptides Cycling 45:43 Non Toxic Sunscreen Choices 47:14 Deodorants and Aluminum 48:18 AirPods and Brain Health 50:26 Cancer Screening Strategy 54:30 Breast Imaging Options 56:05 Biopsy Spread Concerns 58:09 Why Medicine Misses Prevention 01:01:55 Personal DES Cancer Journey 01:03:10 IV Vitamin C for Cancer 01:04:26 Where to Follow and Book
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #234 Navigating Weight Loss: Breaking Down Barriers with Dan Go | 20 Aug 2026 | 01:01:13 | |
After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awareness, protein and fiber for satiety, meal timing, restaurant strategies, preserving muscle with low-volume strength training, FFMI as an alternative to BMI, and a balanced view of GLP-1 medications that considers both their benefits and trade-offs. Dan Go is a fitness coach and entrepreneur whose work focuses on helping busy professionals, founders, and entrepreneurs improve their body composition, health, and performance through sustainable nutrition, behavior change, and efficient training. His coaching approach emphasizes identifying the specific habits, beliefs, and environmental factors that make fat loss difficult, then building practical systems and guardrails that clients can maintain long term. Rather than relying on extreme diets or high-volume workouts, he focuses on awareness, consistency, adequate protein, structured eating, and time-efficient strength training to help clients lose fat while preserving muscle. [Dan Go Official Website] — Dan Go (Dan Go) [The High Performance Journal] — Dan Go (Dan Go) [Dan Go on X] — Dan Go (X (formerly Twitter)) [Dan Go on Instagram] — Dan Go (Instagram) [Dan Go Private Coaching] — High Performance Founder / Dan Go (High Performance Founder) [Why I Quit Drinking Alcohol] — Mark Manson (Mark Manson) [A Satiety Index of Common Foods] — S. H. Holt, J. C. Miller, P. Petocz & E. Farmakalidis (PubMed) [Fat-Free Mass Index (FFMI) Research] — Loenneke et al. (PubMed Central (PMC)) [ChatGPT] — OpenAI (ChatGPT) [Claude] — Anthropic (Claude) [Mounjaro (tirzepatide)] — Eli Lilly and Company (Mounjaro) [Ozempic (semaglutide)] — Novo Nordisk (Ozempic)
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:49 Rapid Fat Loss Setup 01:11 Find The Bottleneck 02:38 Late Night Eating Roots 04:21 Mark Manson Case Study 05:55 Metabolic Reset Phase 06:38 After Weight Loss Plan 09:29 Remove Obstacles First 10:59 Sustainable Diet Rules 13:03 No Cheat Meals 13:15 90 10 Ratio Diet 15:27 Tracking For Awareness 18:12 Calorie Blind Spots 19:45 Guardrails Not Counting 21:43 Satiety And Fiber 24:24 GLOP Protein Breakfast 28:36 Why Eat Breakfast 30:14 Breakfast Beats Stress 31:22 Night Eating Guardrails 32:53 Sleep and Late Meals 34:15 Restaurant Ordering Hacks 38:49 Keep Muscle While Cutting 45:30 FFMI Over BMI 47:31 GLP-1s Balanced Take 54:25 Dosing and Nutrition Guardrails 57:50 Men vs Women Fat Loss 59:58 Where to Find Dan Go
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #233 Understanding NAD+: Insights with Dr. Charles Brenner | 13 Aug 2026 | 01:01:20 | |
Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.
Brenner Lab — Charles Brenner, PhD
Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies
Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/
This is the PAD study discussed in the episode where NR improved six-minute walking performance.
NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968
This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.
Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext
This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.
NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/
This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.
Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/
This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.
Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner
Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition | 06 Aug 2026 | 00:55:48 | |
This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, insulin resistance, visceral fat, estradiol, DHT, fertility, and individualized dosing. The conversation also challenges common measures such as BMI and body fat percentage, emphasizing skeletal muscle mass, visceral adiposity, sustainable health goals, and the minimum effective intervention.
Dr. Jonathan Schoeff is a spinal surgeon and longevity medicine practitioner whose work focuses on hormone health, metabolic optimization, body composition, and individualized health strategy. Through comprehensive laboratory testing, clinical assessment, and personalized treatment planning, he helps clients understand how hormones, insulin sensitivity, muscle mass, visceral fat, lifestyle, and long-term health goals interact. Describing his role as that of a "biological strategist," Dr. Schoeff emphasizes precision over standardized protocols and develops practical plans designed around each person's biology, priorities, and daily life.
Health and Human Performance Optimization to Enhance Military Readiness — U.S. Department of War
Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action — Giacomo Tirabassi et al. https://pubmed.ncbi.nlm.nih.gov/26421011/
Comparative Effects of Daily and Weekly Boron Supplementation on Plasma Steroid Hormones and Proinflammatory Cytokines — Mohammad Reza Naghii et al. https://pubmed.ncbi.nlm.nih.gov/21129941/
Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi
Surviving Sepsis Campaign Adult Guidelines — Society of Critical Care Medicine
The Longevity Lab — Dr. Jonathan Schoeff and Candace Schoeff https://longevitylabwellness.com/
Jonathan Schoeff on Instagram — Dr. Jonathan Schoeff https://www.instagram.com/jonschoeff/
Jonathan Schoeff on YouTube — Dr. Jonathan Schoeff https://www.youtube.com/@drjonschoeff
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:42 Military Low T Screening 04:32 Normal Ranges and Treatment 08:19 Free Testosterone and Insulin 12:35 High SHBG and Enclomiphene 15:54 hCG Fertility and Protocols 19:35 Obesity Low T Strategy 23:26 Aromatase Inhibitors and Estrogen 26:51 DHT Mood and Libido Balance 28:57 DHT Balance Risks 30:10 Minimum Effective Dose 31:55 Longevity Strategy Mindset 33:31 Clinic Cuts Alcohol Use 35:40 Goals Drive Strategy 38:06 Body Fat Targets Debate 41:54 Sustainable Leanness 45:33 Personalized Nutrition Plans 48:09 Beyond Body Fat Metrics 52:29 Rules Not Regulations 53:31 Wrap Up And Where To Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics | 30 Jul 2026 | 01:11:54 | |
Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising interventions from overhyped protocols while emphasizing evidence, appropriate dosing, consistency, and individual risk. Dr. Kyle Gillett is a physician and founder of Gillett Health whose work focuses on personalized hormone care, metabolic health, performance, and longevity. He uses laboratory results, symptoms, medical history, lifestyle, and treatment response to guide decisions about hormones, medications, peptides, and supplements. He also hosts the Gillett Health Podcast and founded Sage Bio.
[Gillett Health] — Dr. Kyle Gillett and James O'Hara [The Gillett Health Podcast] — Dr. Kyle Gillett and James O'Hara [Sage Bio Laboratory Testing] — Sage Bio, Inc. [AirDoctor Air Purifiers] — AirDoctor and Ideal Living [Consensus Research Search] — Consensus [Google Scholar] — Google [Cravv Cytisine Product Information] — Health Canada [Juven Therapeutic Nutrition] — Abbott Nutrition [EGRIFTA WR Tesamorelin Prescribing Information] — U.S. Food and Drug Administration [QUVIVIQ Daridorexant Information] — Idorsia Pharmaceuticals [DAYVIGO Lemborexant Information] — Eisai [Micro- and Nanoplastics in Coronary Circulation Study] — Pasquale Paolisso and colleagues, European Heart Journal [CJC-1295 FDA Review Materials] — U.S. Food and Drug Administration, Pharmacy Compounding Advisory Committee [Kyle Gillett, MD on Instagram] — Dr. Kyle Gillett
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Bromantane Overview 02:16 How Bromantane Works 04:45 Trump Debate Stack 06:03 Nicotine Microdosing 08:39 Cartilax vs BPC 12:06 Ultimate Healing Stack 14:09 Healing Supplements 16:26 Tesamorelin Benefits 21:09 Growth Hormone Dosing 22:54 Kids and Height 25:13 Selank and Benzo Taper 28:59 Best Time for BPC 31:03 BPC Safety Risks 33:00 GLP1 Motility Fixes 34:39 Low Dose Naltrexone Uses 36:06 LDN and Alcohol Effects 37:10 GLP-1 Heartburn Fixes 38:42 GLP-1s and Drinking 40:18 Hangover Supplement Stack 42:55 Oral vs Injectable Carnitine 45:27 NAD+ Shots vs Precursors 47:35 Hair Loss Stack for Men 50:44 Topical Dutasteride Strategy 56:06 Hair Loss Stack for Women 56:59 Top Longevity Meds 01:00:28 Aspirin Nuance and Lp 01:02:25 TUDCA for Gallbladder 01:04:36 Leptin Resistance Basics 01:06:33 Microplastics and Indoor Air 01:10:03 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K | 23 Jul 2026 | 01:09:37 | |
Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims. Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.
Quick Coherence Technique — HeartMath https://help.heartmath.com/introduction/quick-coherence-technique/ The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al. https://pubmed.ncbi.nlm.nih.gov/36142272/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific https://www.quicksilverscientific.com/products/facial-beauty-serum Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri Vladimir Khavinson Publications — Professor Vladimir Khavinson https://khavinson.info/publications
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:57 GLP-1 Starting Doses 03:39 GLP-1 Anti Inflammation Aging 07:15 Motility Supplements Side Effects 09:02 Tirzepatide vs Semaglutide 11:46 Adrenal Fatigue Myth 13:23 Fatigue Bloodwork Checklist 16:16 TRT Hematocrit Sleep Apnea 19:01 Underrated Blood Tests 20:06 Womens HRT Basics 22:21 Testosterone for Women 25:19 Thyroid Treatment LDN NAD 29:31 Progesterone GABA Sleep 32:25 Progesterone for Men Debate 33:43 Testosterone Injection Frequency 36:05 TRT Dosing Frequency 36:45 Why TRT Stops Working 37:50 Creams vs Injections 39:08 Fertility and HCG 41:46 Peptides vs Pharma 44:17 HGH and Secretagogues 45:12 5-Amino-1-MQ Hype 48:15 Topical GHK-Cu Skincare 50:25 Injectable Copper Peptide Hair 52:26 BPC 157 and TB500 58:25 Thymosin Alpha 1 Immunity 01:01:13 Mitochondrial Peptides 01:03:20 Endo 205 and New Peptides 01:04:17 Kavinson and Epitalon 01:08:21 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety | 16 Jul 2026 | 01:22:28 | |
Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.
Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling | 09 Jul 2026 | 00:31:33 | |
The episode explains how to use minoxidil for hair loss, emphasizing that it supports follicles and prolongs the anagen phase but does not block DHT (with topical dutasteride mentioned as a scalp-focused DHT option). It reviews evidence that 5% topical minoxidil is optimal (better than 2% and superior to 10%), works best on the crown/vertex, and should be applied to the scalp—not the hair—with expectations set for gradual results and possible early shedding. Twice-daily topical use is recommended unless combined with 0.01% tretinoin, which can make once-daily use similarly effective, though irritation can occur. Microneedling combined with minoxidil is strongly recommended based on a 2013 RCT, with guidance on depth (0.5–1.0 mm), frequency, and waiting 12–24 hours (or longer with tretinoin) before applying minoxidil. The episode also compares oral minoxidil dosing, notes a 2024 RCT showing similar outcomes to topical at 5 mg, and details systemic side effects, monitoring, and cautions including pet toxicity with topical use.
Full Hair Loss Podcast — Wnt vs DHT https://www.youtube.com/watch?v=bswq-Qhfebs
Minoxidil + Microneedling — 2013 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC3746236/
5% vs 2% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/12196747/
5% vs 10% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/31403367/
Minoxidil + 0.01% Tretinoin Study https://pubmed.ncbi.nlm.nih.gov/17902730/
Oral vs Topical Minoxidil — 2024 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11007651/
Topical Dutasteride Study https://pmc.ncbi.nlm.nih.gov/articles/PMC12405733/
Topical Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a689003.html
Oral Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a682608.html
Tretinoin Drug Information https://medlineplus.gov/druginfo/meds/a682437.html
Dutasteride Drug Information https://medlineplus.gov/druginfo/meds/a603001.html
Minoxidil Toxicity in Dogs and Cats https://pubmed.ncbi.nlm.nih.gov/34370845/
Sildenafil / Viagra Drug Information https://medlineplus.gov/druginfo/meds/a699015.html
Tadalafil / Cialis Drug Information https://medlineplus.gov/druginfo/meds/a604008.html
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:45 Minoxidil Basics 01:43 DHT And What It Misses 03:07 How Minoxidil Works 03:55 Best Areas To Treat 04:30 Choosing The Right Strength 05:55 Once Or Twice Daily 08:28 Applying It Correctly 10:10 Microneedling Protocol 15:17 Formulations And Routine 18:14 Topical Side Effects 19:34 Shedding And Pet Safety 20:44 Oral Minoxidil Overview 22:53 Dosing And Risks 27:39 Combining Oral And Topical 28:36 Final Takeaways
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency | 02 Jul 2026 | 00:29:03 | |
The speaker shares a structured, consistent diet designed to support hard training (three strength sessions, Norwegian 4x4, Zone 2 cardio, and one MMA session weekly), reduce "food noise," and stay full with high protein and fiber. He explains cooling/freezing rice to increase resistant starch and lower glycemic impact, then details his daily routine: a morning shake with creatine, collagen peptides, greens/red powder, and beta-alanine; four eggs mid-morning; high-protein Greek yogurt mixed with psyllium husk and acacia fiber; a pre-workout oats-and-whey bowl; a post-workout shake with whey, berries, vegetables, and sauerkraut; and a batch-prepped dinner of extra-lean ground beef, basmati rice, avocado, and sauce, plus a small yogurt-and-berries snack. Daily totals are about 2600 calories with ~260g protein, ~262g carbs, ~62–80g fat, and ~42g fiber, with weekend flexibility including two gin martinis and restaurant meals like steak or occasional pasta.
Norwegian 4x4 Protocol https://www.ntnu.edu/cerg/advice
VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio
Creatine / Athletic Performance https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/
Creatine / Sleep Deprivation Study https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/
Multi Collagen Peptides https://pmc.ncbi.nlm.nih.gov/articles/PMC8521576/
Collagen Before Exercise Study https://pmc.ncbi.nlm.nih.gov/articles/PMC5183725/
ATP Labs Greens & Reds https://atplab.com/products/green-red-whole-foods-100-organic
Beta-Alanine https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/
Coenzyme Q10 https://www.nccih.nih.gov/health/coenzyme-q10
Fish Oil / Omega-3 https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/
Oikos High Protein Greek Yogurt https://www.oikos.ca/en/oikos-high-protein
Psyllium Husk / LDL Cholesterol
Acacia Fiber / Gut Microbiome https://pmc.ncbi.nlm.nih.gov/articles/PMC8296006/
Short-Chain Fatty Acids / Butyrate https://pmc.ncbi.nlm.nih.gov/articles/PMC8153313/
Grass-Fed Whey Protein https://atplab.com/products/grass-fed-whey
Fermented Foods / Sauerkraut https://pmc.ncbi.nlm.nih.gov/articles/PMC9020749/
Resistant Starch / Cooled Rice Study https://pmc.ncbi.nlm.nih.gov/articles/PMC9013350/
Quest Protein Bars https://www.questnutrition.com/collections/protein-bars
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:45 Diet Goals and Structure 01:58 Training Schedule and Carbs 03:42 Morning Supplements Stack 07:19 First Meal Eggs and Fats 09:00 Greek Yogurt Fiber Snack 11:26 Pre Workout Oats and Whey 13:22 Post Workout Shake and Gut Health 15:19 Dinner Meal Prep Beef Rice Avocado 18:40 Evening Snack and Sleep Timing 19:58 Daily Macros and Protein Targets 20:58 Weekend Flex Meals and Alcohol 24:30 Extra Foods and Final Takeaways 28:23 Wrap Up and Thanks
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine | 25 Jun 2026 | 01:01:09 | |
Dr. Kristin Collier joins Dr. Mike Hart to discuss the ethical, cultural, and technological forces reshaping modern medicine. Reflecting on the 2022 white coat speech walkout, she explores viewpoint diversity, self-censorship, moral courage, and the importance of cultivating wisdom alongside technical skill in medical education. The conversation also examines physician-assisted suicide, its relationship to suicide prevention, mental illness, disability, chronic disease, palliative care, healthcare funding, and the protection of vulnerable patients. They also discuss the promise and risks of artificial intelligence in medicine, including concerns about weakened clinical reasoning and the loss of person-to-person care, as well as spirituality, meaning, reproductive ethics, IVF, abortion, and human dignity. Dr. Kristin Collier is a physician, medical educator, and bioethics scholar whose work focuses on medical education, spirituality in healthcare, human dignity, and the moral responsibilities of physicians. Drawing from her experience teaching future doctors and caring for patients, she examines how wisdom, compassion, intellectual freedom, and ethical reflection can help medicine remain both scientifically rigorous and deeply human. Truth Matters — Robert P. George and Cornel West The Age of Feelings: Recovering the Truth Meditations — Marcus Aurelius Medical Wisdom with Kristin Collier Moral Diversity for Medical Trainees Moral Diversity for Medical Trainees — DOI Professionalism in Modern Medicine: Does the Emperor Have Any Clothes? The Patient as a Person — Abraham Joshua Heschel Physician-Assisted Suicide Isn't Healthcare AMA Code of Medical Ethics — Physician-Assisted Suicide AMA Report on Assisted-Suicide Terminology AMA Physician-Assisted Suicide Report Stephanie Packer's Story Oregon Death With Dignity Act Reports Oregon Death With Dignity Act 2025 Report The Death Treatment — Rachel Aviv Canadian MAID Public-Opinion Survey Health Canada Annual MAID Report Physician-Assisted Suicide and MAID Debate In Vitro Fertilization: A Good End by Bad Means In Vitro Fertilization Article — DOI Roe v. Wade Kristin Collier — University of Michigan Kristin Collier X / Twitter Kristin Collier — PubMed Publications Kristin Collier — Google Scholar Kristin Collier — Apple Podcasts
Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:44 Patients React to Intolerance 04:14 Cancel Culture in Medicine 08:05 Private Support and Fear 09:22 Moral Courage in Academia 11:17 Courage Versus Conformity 13:30 Why Medicine Needs Wisdom 16:45 Viewpoint Diversity in Training 22:29 Stoicism and Detached Concern 25:36 Physician Assisted Suicide Debate 29:51 Is It Ever Compassionate 31:49 Hard Cases and Suffering Care 32:20 Compassion Beyond Killing 33:09 Why People Request MAID 33:56 Suicide Prevention Paradox 37:00 Mental Illness and Euthanasia 40:02 Psychedelics Versus MAID 42:12 Euthanasia as a Hammer 46:23 AI Threats to Medicine 51:40 AI in Training Today 52:45 Spirituality and Meaning 56:11 Pro Life Pro Woman 58:33 Human Dignity Closing The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss | 18 Jun 2026 | 00:59:17 | |
This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication. Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results. Dr. Christle Guevarra Website Dr. Christle's Free GLP-1 Guide https://www.drchristle.com/glp1-guide Dr. Christle Instagram https://www.instagram.com/dr.christle/ Ozempic — semaglutide Wegovy — semaglutide for weight management Mounjaro — tirzepatide Zepbound — tirzepatide for weight management / sleep apnea FDA: Concerns With Unapproved GLP-1 Drugs Retatrutide Clinical Trial Info https://clinicaltrials.gov/study/NCT05882045 Vyvanse — lisdexamfetamine https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Creatine — NIH Supplement Info https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Psyllium Husk / Fiber — MedlinePlus https://medlineplus.gov/druginfo/meds/a601104.html Berberine — NCCIH https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know Tesamorelin — MedlinePlus https://medlineplus.gov/druginfo/meds/a611035.html CJC-1295 — PubMed Research https://pubmed.ncbi.nlm.nih.gov/16352683/ Ipamorelin — PubMed Research https://pubmed.ncbi.nlm.nih.gov/9849822/ FDA: Peptides / Compounding Safety Concerns Oura Ring White Claw
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Weekly Dosing Debate 03:41 Starting Dose Basics 06:28 Pens vs Vials Safety 08:37 Finding Your Sweet Spot 11:01 Nighttime Binge Window 13:32 Lifestyle Work Still Matters 14:30 Benefits Beyond Weight 17:27 Libido and Low Calories 22:26 Alcohol Hits Different 24:59 Cancer Claims Reality Check 26:59 Strength Training Priority 29:06 Supplements and Creatine 29:38 Creatine Protein Fiber Basics 31:50 Berberine Pros and Cons 32:37 Peptides Sleep and Muscle 35:28 Too Lean for GLP-1 38:52 Cycles PCOS and Fertility 40:45 Food Noise vs Appetite 44:42 Staying On or Stopping 49:19 Heart Rate and HRV Concerns 51:38 Ozempic vs Mounjaro Choices 54:45 Sleep Apnea and Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement | 11 Jun 2026 | 01:06:29 | |
Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC meeting. He explains most peptide APIs and many compounded GLP-1 ingredients come from China, while pharma-grade GLP-1s have more U.S. production. The discussion covers retatrutide's potential biologic classification (40–amino acid rule) and pricing implications, MOTS-c as an adjunct for low energy on GLP-1s, skepticism about cardarine, growth hormone secretagogues and cancer fears, TRT dosing frequency, sleep apnea screening, HCG's roles, and penis enhancement via traction for length and hyaluronic acid filler for girth, emphasizing expectations and mental health. Dr. Alex Tatem is a board-certified urologist focused on men's health, hormone optimization, male fertility, and sexual wellness. In this episode, he joins Dr. Mike Hart to discuss the changing landscape of peptide therapy, including FDA restrictions, compounding pharmacies, drug supply chains, and the growing debate around access to treatments such as BPC-157, MOTS-c, and retatrutide. He also breaks down practical considerations for men using testosterone replacement therapy, including HCG, fertility preservation, dosing frequency, estrogen-related side effects, and sleep apnea risk. Drawing from his experience treating a wide range of patients, he shares a harm-reduction approach to performance medicine and explains what men should understand before considering growth hormone peptides, GLP-1 medications, or penile enhancement procedures. Dr. Alex Tatem Website Dr. Alex Tatem Instagram https://www.instagram.com/dralextatem/ Huberman Lab — Peptides: The Science, Uses & Safety | Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri FDA Pharmacy Compounding Advisory Committee Meeting — July 23–24, 2026 FDA Bulk Drug Substances Under Section 503A FDA Compounding Safety Risks Semaglutide / Ozempic https://medlineplus.gov/druginfo/meds/a618008.html Tirzepatide / Mounjaro https://medlineplus.gov/druginfo/meds/a622044.html Retatrutide Clinical Trial https://clinicaltrials.gov/study/NCT05929066 Testosterone Cypionate https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=testosterone%20cypionate Human Chorionic Gonadotropin / HCG https://pubmed.ncbi.nlm.nih.gov/?term=human+chorionic+gonadotropin BPC-157 https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157 KPV Peptide https://pubmed.ncbi.nlm.nih.gov/?term=KPV+peptide TB-500 / Thymosin Beta-4 https://pubmed.ncbi.nlm.nih.gov/?term=thymosin+beta-4 MOTS-c https://pubmed.ncbi.nlm.nih.gov/?term=MOTS-c CJC-1295 https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295 Ibutamoren / MK-677 https://pubmed.ncbi.nlm.nih.gov/?term=ibutamoren+MK-677 Cardarine / GW501516 https://pubmed.ncbi.nlm.nih.gov/?term=GW501516+cardarine PhalloFILL at Urology of Indiana https://menshealthin.com/services/phallofill/ Hyaluronic Acid Penile Girth Enhancement Overview
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 Are Peptides Threatening Pharma 01:17 Patent Law and FDA Categories 02:19 The 2023 Peptide Ban Fallout 03:59 Safety or Money Debate 06:09 China Supply Chain Exposed 11:33 RFK Jr Peptide Messaging 16:01 Retatrutide Biologic Fight 20:51 What Biologic Status Costs 25:27 MOTS-c as GLP-1 Booster 28:43 Growth Hormone Cancer Myth 32:18 Sleep Effects and Bryan Johnson 35:04 Microplastics and Saunas 36:48 Cardarine Cancer Risk 40:07 TRT and HCG Basics 45:08 HCG Dosing Nuance 49:06 Daily TRT Microdosing 52:03 Sleep Apnea on TRT 56:34 Penis Enhancement Options 01:02:54 Realistic Expectations 01:04:46 Wrap Up and Where to Follow
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #223 How I Increased My VO2 Max at 41 With the Norwegian 4x4 Protocol | 28 May 2026 | 00:34:52 | |
The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus weekly MMA, he shifted to one zone 2 session, one Norwegian 4x4 VO2 max workout, and one MMA session weekly. He defines VO2 max and details the 4x4 protocol (4 minutes hard/3 minutes easy for 4 rounds plus brief warmup/cooldown), using a COROS heart rate monitor to track significant zone 5 time. Starting at 8.0 mph, he increased treadmill speed by 0.1 mph weekly to 9.3 mph, discussing deload weeks, fatigue limits, body weight changes, footwear, sauna frequency, and mixed views on supplements like beta-alanine, beetroot, and ketones.
Norwegian 4x4 Protocol VO2 Max / Zone 2 Cardio Stats Canada VO2 Max Percentile Table Oura Ring COROS Heart Rate Monitor Freak Athlete Nordic Hyper / Hyper Pro HOKA Clifton 10 Nike Zoom Fly Post-Exercise Sauna Bathing Study Urolithin A Beetroot / Dietary Nitrate Ketone-IQ Beta-Hydroxybutyrate / BHB Ketones L-Citrulline Creatine Beta-Alanine MOTS-c Cardarine / GW501516 Brady Holmer Hart2Heart Episode with Brady Holmer
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 VO2 Max Story Setup 01:27 Baseline Training Split 02:58 What VO2 Max Means 05:10 Why Add Structure 06:01 Norwegian 4x4 Explained 06:49 Starting Speeds Recovery 08:07 Zone 5 Targets 10:55 Tracking Heart Rate 12:23 Estimating VO2 Max 14:37 Zone 2 And MMA Role 17:20 Bodyweight And Running 19:46 Shoes Sauna Supplements 24:44 Progressive Overload Plan 29:34 Deloads Plateaus Mindset 31:29 Final Takeaways Encouragement
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia | 21 May 2026 | 01:03:28 | |
Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis PT-141 / Bremelanotide GHK-Cu copper peptide Tretinoin / Retin-A NAD+ Nicotinamide Riboside / NR Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione GLP-1 drugs Tirzepatide BPC-157 TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test Tesamorelin
Thymosin Alpha-1 SS-31 / Elamipretide Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes Psyllium husk
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #221 Acute vs. Chronic Inflammation: Causes, Biomarkers, and How to Lower It | 14 May 2026 | 00:58:24 | |
The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin resistance), poor sleep and sleep apnea, ultra-processed foods, sedentary behavior, overtraining, chronic psychological stress, poor oral health, gut dysbiosis/barrier issues, smoking, alcohol, pollution, autoimmune disease, and chronic infection. The host reviews biomarkers to discuss with a physician such as high-sensitivity CRP, ESR, ferritin, WBC and neutrophil-to-lymphocyte ratio, fasting insulin, ApoB, omega-3 index/omega-6:omega-3 ratio, and homocysteine. Chronic inflammation is linked to cardiovascular disease, depression/anhedonia, brain fog, autoimmune disease risk, cancer mechanisms, skin aging, erectile dysfunction, and chronic pain. Treatment focuses on lifestyle (notably treating sleep apnea, sleep optimization, fat loss, exercise, oral health, omega-3 intake, sauna, stress regulation, circadian rhythm), selected supplements (vitamin D if deficient, curcumin, boswellia, ginger, garlic, olive oil polyphenols, sulforaphane, magnesium/glycine, taurine, NAC, quercetin, probiotics, creatine), and brief discussion of drugs including GLP-1 agonists, colchicine, NSAIDs, corticosteroids, and biologics.
Chronic inflammation C-reactive protein test ESR blood test Ferritin blood test Homocysteine test ApoB test Insulin resistance Obstructive sleep apnea CPAP therapy Sleep hygiene Physical activity guidelines Ultra-processed foods Gum disease Gut microbiome Fiber Autoimmune diseases Inflammation and heart disease Inflammation and depression Cancer and chronic inflammation Omega-3 supplements
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 Inflammation Basics 01:24 Acute Versus Chronic 03:29 Chronic Disease Link 03:52 Visceral Fat Driver 06:06 Sleep And Apnea 12:33 Food And Movement 16:02 Stress And Oral Health 18:17 Gut And Fiber 21:17 Toxins Autoimmune Infection 26:05 Inflammation Biomarkers 27:13 Inflammation Blood Markers 28:37 Ferritin Iron Balance 30:07 Metabolic Cardio Labs 32:08 Omega 3 Index Insights 34:07 Homocysteine Risks 34:58 Why Inflammation Matters 41:07 Lifestyle Fixes 46:24 Supplement Options 54:36 Medication Overview 57:36 Final Takeaways
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #220 Wnt vs DHT: Understanding Androgenic Alopecia and the Top Treatments to Slow Hair Loss | 07 May 2026 | 00:41:17 | |
In this solo episode on androgenic alopecia, the host explains that hair loss is slow and progressive, driven largely by genetics and DHT-mediated miniaturization of follicles across the anagen, catagen, and telogen cycle, and stresses early detection using periodic photos of the temples, hairline/vertex, and crown. He frames hair growth as a "battle" between Wnt signaling (promotes growth and anagen entry via stem cell activation) and DHT signaling (suppresses Wnt and increases inhibitors like DKK, TGF-beta, and PGD2), noting advanced loss involves inflammation, fibrosis, and irreversible follicle loss. He reviews contributors like poor scalp blood flow, iron deficiency (most evidence), possible zinc/B12/folate deficiency, thyroid dysfunction, and insulin resistance, then covers treatments: finasteride (oral and topical) and dutasteride as DHT blockers with potential systemic side effects, plus minoxidil and microneedling (home vs professional) as key options, with add-ons like ketoconazole shampoo, PRP, red light, and cautions about anabolic steroids and high-dose testosterone increasing DHT pressure.
Hair loss diagnosis and treatment Androgenetic alopecia DHT and WNT signaling Finasteride Topical finasteride FDA warning on compounded topical finasteride Post-finasteride syndrome Dutasteride Minoxidil Microneedling for hair loss Ketoconazole shampoo Topical caffeine Pumpkin seed oil PRP for hair loss Red light / low-level light therapy Stem cells / exosomes for hair growth Iron, zinc, B12, and folate deficiencies Thyroid testing Insulin resistance / metabolic syndrome Testosterone / TRT Tretinoin Anastrozole / Arimidex Anabolic steroids
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:56 What Is Androgenic Alopecia 02:17 Hair Follicle Life Cycle 03:55 Miniaturization and Early Detection 06:51 DHT Basics and Other Causes 09:27 WNT Versus DHT Explained 13:10 Nutrients Thyroid and Insulin 16:26 Finasteride Benefits and Risks 19:21 Topical Finasteride and Dutasteride 25:01 Minoxidil Growth Booster 27:19 Microneedling for WNT Activation 30:21 Extra Treatments and Add Ons 37:04 Testosterone TRT and Steroids 40:16 Wrap Up and Key Takeaways
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #219 Dr. Allen Frances on AI Chatbots, Mental Health Risks, Privacy, and the Overdiagnosis of Autism | 30 Apr 2026 | 00:46:54 | |
Dr. Allen Frances discusses how AI chatbots can provide effective support for everyday stress and mild symptoms, with tens of millions using them, but warns they can be dangerous for vulnerable groups—especially the very young, the very old, the socially isolated, and people with severe mental illness—potentially contributing to psychosis, suicide, or eating disorders. He argues harm is driven by chatbots being programmed to be pleasing and validating to maximize screen time, creating dependency and "echo chambers," and highlights major privacy risks and manipulation potential given extensive data collection and weak safeguards. Frances advocates a hybrid model where therapists and patients train chatbots as assistants aligned with treatment goals, and cautions about industry profit motives, limited regulation, scams, political propaganda, and broader societal risks. He also explains autism's overdiagnosis since DSM-IV's expansion (Asperger's/autism spectrum) and describes ADHD and autism as current fad diagnoses amplified by services and social media.
Dr. Allen Frances is a psychiatrist, author, and leading voice on psychiatric diagnosis, mental health, and the risks of overmedicalization. He is widely known for his work on the DSM-IV and for his book Saving Normal, which challenges the overdiagnosis and overtreatment of everyday life struggles. In this episode, he joins Dr. Mike Hart to break down the growing impact of AI chatbots on mental health, therapy, privacy, and clinical care. He explains when chatbot support may be helpful, why vulnerable users can be harmed, how AI could reshape psychotherapy, and why privacy with chatbots may be an illusion. He also discusses the overdiagnosis of autism and ADHD, the role of social media in self-diagnosis, and why false labels can change how people see themselves and their future. Books & ArticlesSaving Normal — Allen Frances Allen Frances — Psychiatric Times Articles 1984 — George Orwell ChatGPT / OpenAI Claude / Anthropic Grok / xAI Character.AI Replika Signal TikTok EU AI Act Australia Social Media Age Restrictions Kaiser Mental Health Workers AI Strike Psychiatry, Diagnosis & Mental Health References DSM-5-TR Autism Spectrum Disorder — NIMH ADHD — CDC SSRIs — FDA Hippocratic Oath Historical / Therapy References ELIZA Chatbot Carl Rogers
Show Notes
00:00 Welcome to the Hart2Heart Podcast 00:49 Benefits vs Dangers 01:52 Engagement and Validation Trap 03:21 Who Is Most at Risk 04:19 When Chatbots Help 05:43 Hybrid Therapy Future 06:52 How to Train Assistants 08:47 Therapists Must Adapt 09:33 Healthcare Replacement Nightmare 11:15 Human Touch vs AI Limits 12:41 Suicide Risk and Lawsuits 14:43 SSRIs and Primary Care 16:56 Everyday Use and Vulnerables 19:12 Regulation and Kids 22:03 AI Power and Resource Costs 23:43 Deepfake Psychiatrists 24:30 Most Dystopian Takeover 25:50 AI Dependency Dangers 27:11 Why No One Pauses AI 28:41 EU Regulation Falling Behind 29:36 AI Hacking Breakthrough 30:38 Chatbot Privacy Myth 32:53 Protecting Yourself Online 35:26 Echo Chambers Manipulation 37:17 Scams Deepfakes Politics 40:44 Autism Overdiagnosis DSM 44:13 ADHD Fad Diagnosis Risks 45:53 Wrap Up Resources
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #218 Lab-Grown Meat, Grocery Prices, and the Real Drivers of Food Inflation in Canada (with the Food Professor) | 23 Apr 2026 | 00:53:47 | |
In a wide-ranging interview, Dr. Sylvain Charlebois ("The Food Professor") discusses whether lab-grown (cellular) meat is overhyped, citing consumer acceptance, cost, and labeling as key barriers, though he found lab-grown chicken indistinguishable in taste and notes potential for nutrient customization. The conversation then turns to Canadian food inflation, arguing there is little evidence grocers are gouging consumers via higher margins, though grocers pressure suppliers through fees, affecting prices and supply-chain discipline. Charlebois contends food inflation is largely structural and policy-driven, pointing to trade barriers, carbon tax impacts, logistics, supply management, counter-tariffs, and the GST holiday's inflationary effect. He proposes solutions focused on competition, tax relief, logistics investment, and policy reform, and closes with a cautious view of ultra-processed food rhetoric, emphasizing consumer information over bans.
Dr. Sylvain Charlebois is a professor of food distribution and policy at Dalhousie University and director of the Agri-Food Analytics Lab, where his work focuses on food distribution, food policy, food security, and food safety. Widely known as "The Food Professor," he is one of Canada's most recognized voices on food inflation, grocery pricing, supply chains, and the future of food. His research has been featured in major outlets including The Economist, The New York Times, The Wall Street Journal, and The Globe and Mail, and he also hosts The Food Professor Podcast. In this episode, he breaks down what's really driving food prices in Canada, whether grocers are being unfairly blamed, the debate around lab-grown meat, and how ultra-processed foods and GLP-1 drugs are reshaping the food industry.
Sylvain / The Food Professor The Food Professor on X — https://x.com/FoodProfessor Sylvain Charlebois on LinkedIn — https://ca.linkedin.com/in/thefoodprofessor The Food Professor Podcast — https://the-food-professor.simplecast.com/ Food Tech / Salmon AquaBounty — https://aquabounty.com/our-salmon/why-aquabounty-salmon FDA AquAdvantage Salmon Fact Sheet — https://www.fda.gov/animal-veterinary/aquadvantage-salmon/aquadvantage-salmon-fact-sheet Sustainable Blue — https://www.sustainableblue.com/ Canada Food Policy / Data Canada Grocery Code of Conduct — https://canadacode.org/ Code of Conduct Page — https://canadacode.org/code/code-of-conduct/ Health Canada Front-of-Package Nutrition Symbol — https://www.canada.ca/en/health-canada/services/food-nutrition/nutrition-labelling/front-package.html Statistics Canada Household Income — https://www.statcan.gc.ca/hub-carrefour/quality-life-qualite-vie/prosperity-prosperite/household-income-revenu-menage-eng.htm GST/HST Holiday Page — https://www.canada.ca/en/services/taxes/child-and-family-benefits/gst-hst-holiday-tax-break.html David Dodge, Bank of Canada Profile — https://www.bankofcanada.ca/profile/david-dodge/ Companies / Brands Mentioned Loblaw Companies — https://loblaw.ca/ Sobeys — https://www.sobeys.com/ Walmart Canada — https://www.walmartcanada.ca/ CBC Organization Profile — https://federal-organizations.canada.ca/profil.php?OrgID=CBC&lang=en Johnson & Johnson — https://www.jnj.com/ McDonald's Canada — https://www.mcdonalds.com/ca/en-ca.html GLP-1 / Weight Loss Drugs Ozempic Canada — https://www.ozempic.ca/en_ca.html Wegovy Canada — https://www.wegovy.ca/en_ca.html Media / Podcast Reference The Joe Rogan Experience — https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk
Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:37 Lab Meat Hype Cycle 01:50 How Cultured Meat Works 03:06 Acceptance and Cost Barriers 04:46 Taste Test and Nutrition Tweaks 06:54 Vegans Vegetarians and Labeling 14:53 Canada Food Inflation Debate 15:57 Grocers Fees and Supplier Squeeze 17:40 Policy Roots and Middle Class Squeeze 21:06 Fixes Without More Spending 23:27 Supply Management Price Premiums 24:51 Politics Crises and Inflation Spending 26:53 Inflation And Taxes 27:38 Conservative Policy Impact 28:19 Grocer Margins And Manufacturing 30:05 GST Holiday Backfire 33:18 Media Blind Spots 35:05 Counter Tariffs Price Ripple 37:41 Carney Versus Poilievre 42:53 Media Subsidies And CBC 44:39 Ultra Processed Food Debate 48:54 Addiction Obesity And GLP1 51:30 Regulation Tradeoffs Wrap Up 52:51 Where To Follow Closing
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike HartInstagram: @drmikehart | |||
| #217 Dr. Russell Kennedy on Anxiety as a Body Alarm: Childhood Patterns, Worry, Somatic Healing | 16 Apr 2026 | 01:08:25 | |
Dr. Mike Hart interviews Dr. Russell Kennedy about chronic anxiety as a childhood safety adaptation that never turns off, driven more by a body-based "alarm" than by thinking. Kennedy explains why understanding anxiety and talk-based cognitive approaches often have limited effect because subcortical systems communicate through feeling; alarm sensations trigger the mind to generate worries, which can become dopamine-reinforced and addictive. He discusses sensitivity (often cited as 15–20% of the population), modern stressors like smartphones and social media reducing discomfort tolerance, and high-functioning anxiety in high achievers and physicians, with sleep as a key regulation marker. Kennedy emphasizes reconnecting mind and body and adult self with younger self using somatic techniques (body scanning, hand placement, "sensation without explanation," and the SHOULD acronym), notes trauma can occur without an overtly traumatic life, links dysregulated autonomic states to varied symptoms, and shares rapid tools like the physiological sigh and alternate nostril breathing, plus his "Sanity" app and AnxietyMD resources. Dr. Russell Kennedy is a physician, author, and anxiety expert whose work explores the deeper roots of chronic anxiety, especially the role of childhood stress, nervous system dysregulation, and the body's stored alarm response. In this episode, he explains why anxiety is not just a thinking problem but a feeling problem, how worry becomes a coping pattern that keeps people stuck, why high performers often live in a state of hidden dysregulation, and how self-connection, somatic awareness, and better sleep can help break the cycle. Through a blend of clinical experience, neuroscience, and personal insight, Kennedy helps listeners better understand where anxiety comes from and what it actually takes to heal it at the root.
Official site: Instagram: https://www.instagram.com/theanxietymd/ YouTube: https://www.youtube.com/c/DrRussellKennedyTHEANXIETYMD
Therapies Mentioned Internal Family Systems (IFS): Somatic Experiencing / somatic therapy: Physiological sigh: https://www.hubermanlab.com/newsletter/breathwork-protocols-for-health-focus-stress Alternate nostril breathing: https://www.health.harvard.edu/healthy-aging-and-longevity/alternate-nostril-breath
Pain / Neuroplasticity Resources Alan Gordon / Pain Psychology Center: https://painpsychologycenter.com/our-team Pain Reprocessing Therapy: https://www.painreprocessingtherapy.com/
Experts Mentioned David Goggins: Joseph LeDoux: https://www.joseph-ledoux.com/ Dr. Ethan Russo: Clinical endocannabinoid deficiency paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/15159679/
Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:19 Anxiety Starts in the Body 03:17 Sensitivity and Modern Stress 05:58 The Dopamine Worry Loop 08:08 Self Connection Over Self Punishment 09:09 High Functioning Anxiety and Burnout 12:41 Redefining Success Internally 17:19 Discipline vs Dysregulation 21:46 Mind Body Child Separation 27:10 Finding the Alarm Sensation 29:16 Somatic Steps to Soothe Alarm 33:18 Why We Should Say Alarm 35:07 Medicine Limits and SSRIs 35:36 Medicine Misses Root Causes 36:57 Trauma Behind Weird Symptoms 38:58 Fibro IBS and Nervous System 42:31 Forgiveness and Doctor Burnout 50:51 Biohacking Anxiety Spiral 56:56 Somatic Healing and Spirit 01:02:50 Psychedelics Need Foundation 01:03:39 Physiological Sigh Tools 01:06:24 App Plug and Farewell
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #216 VO2 Max, Zone 2 Training, HRV Wearables, Sauna, and Evidence-Based Performance Supplements with Brady Holmer | 02 Apr 2026 | 01:13:05 | |
Dr. Mike Hart interviews elite runner Brady Holmer about endurance training, VO2 max physiology, and common misconceptions. Holmer explains that zone 2 builds the aerobic base and enables high training volume with less fatigue, notes heart-rate zones are ideally defined by lactate thresholds, and says he primarily uses perceived exertion rather than lactate or heart rate during training. He advises against guiding workouts by wearable HRV scores, arguing accurate HRV requires standardized morning measurements and that wearable data can create a nocebo effect; trends may be informative, but subjective feel should come first. They discuss polarized vs pyramidal training and typical 80/20 intensity distributions, effective session durations, mechanisms limiting VO2 max (central vs peripheral), and why Norwegian 4x4 intervals work by maximizing time near 85–90% max heart rate. They cover breathing/nose breathing, inspiratory muscle training, sauna/hot baths as performance adjuncts, nutrition timing of carbohydrates, and supplements including beetroot, beta-alanine, urolithin A, and post-exercise ketones. Brady Holmer is an endurance-focused performance expert and elite runner whose work explores the science and practice of aerobic fitness, VO2 max, recovery, and smarter cardio training. In this episode, he explains how zone 2 training builds the foundation for endurance, why HRV and wearable data should be interpreted carefully, and how protocols like Norwegian 4x4 can improve performance when used in the right context. Through a blend of long-term training experience, research literacy, and practical coaching insight, Holmer helps listeners better understand how to train harder, recover smarter, and think more clearly about what actually improves cardiovascular fitness.
Training & Cardio Zone 2 Cardio Overview (Cleveland Clinic): https://health.clevelandclinic.org/zone-2-cardio
Lactate / Threshold-Based Training Threshold zones review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC6537749/
Lactate-guided threshold interval training (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC10000870/
Norwegian 4x4 Classic VO2 max paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/17414804/
4x4 protocol heart-rate response study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC7399937/
Polarized Training Meta-analysis / review (PubMed): https://pubmed.ncbi.nlm.nih.gov/38717713/
Older landmark paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/24550842/
Pyramidal Training Pyramidal vs. polarized study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC9299127/
HRV & Wearables
Marco Altini Official site: https://www.marcoaltini.com/ HRV4Training: https://www.hrv4training.com/
HRV Measurement / Use HRV4Training article with Marco Altini: https://www.hrv4training.com/blog2/heart-rate-variability-hrv-training-with-dr-marco-altini-how-to-exercise-using-hrv
Oura Ring Official: https://ouraring.com/
WHOOP Official: https://www.whoop.com/
Experts & Writing
Dr. Andy Galpin Official site: https://www.andygalpin.com/
Brady Holmer Substack profile: https://substack.com/@bradyholmer
Physiologically Speaking: https://www.physiologicallyspeaking.com/
Supplements & Recovery Exercise / Performance Supplements NIH overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/
Creatine Cleveland Clinic overview: https://my.clevelandclinic.org/health/treatments/17674-creatine
Beta-Alanine NIH consumer overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/
ISSN position stand (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/
Beetroot / Dietary Nitrate Review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4008816/
Meta-analysis (PubMed): https://pubmed.ncbi.nlm.nih.gov/23580439/
Urolithin A Mitopure / official: https://www.mitopure.com/
Altitude training camp study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC12628386/
Exogenous Ketones Ketone-IQ official: https://ketone.com/
Post-exercise ketone monoester and EPO study (PubMed): https://pubmed.ncbi.nlm.nih.gov/36449571/
Post-exercise ketones improved endurance training adaptations study (PubMed): https://pubmed.ncbi.nlm.nih.gov/41757674/
Show Notes 00:00 HRV Training Myth 00:59 Zone Two Benefits 02:11 Finding True Zone Two 03:59 RPE Over Wearables 06:27 HRV Done Right 12:06 80 20 Training Split 15:23 Zone Two Session Length 18:37 Cardio Adaptation Science 24:03 Norwegian 4x4 Explained 30:30 Sports Versus Machines 32:54 Leg Day Timing Tips 34:58 Best Leg Exercises 38:21 Nordic Curl Reality Check 39:11 Portable Nordic Setup Tips 39:51 Biggest Running Mistake 40:18 Nose Breathing Zone Two 42:16 Breathing Tools And Myths 43:08 Inspiratory Muscle Training 44:51 How Much Benefit Really 46:27 Sauna For VO2 Max 48:35 Heat Mimics Altitude 50:59 Sauna Fertility Debate 52:54 Red Light Therapy Reality 54:30 Carbs Fuel The Work 56:25 Timing Carbs Around Training 57:52 Best Carb Food Choices 59:41 Supplements For Cardio 01:00:20 Creatine Beta Alanine Beetroot 01:02:16 Urolithin A Breakthrough 01:05:01 Ketones After Training 01:07:31 Other Supplements And Caffeine 01:09:07 SARMs Peptides And Doping 01:10:10 VO2 Max And Longevity 01:10:49 Wrap Up And Where To Follow
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #215 Brain Health From Morning to Night: Sleep, Exercise, Supplements, Screens, and ADHD Meds | 26 Mar 2026 | 00:56:47 | |
Dr. Tommy Wood discusses evidence that stimulants can help people with ADHD but may worsen complex cognitive performance in non-ADHD users despite feeling more focused. He outlines an ideal brain-health day centered on consistent sleep opportunity, morning caffeine timed to protect sleep, nutrient-dense meals (protein, B vitamins, omega-3s, fiber, antioxidants), frequent movement to break up sedentary time, and structured exercise including cardio, resistance training, HIIT (notably Norwegian 4x4), and open-skill sports for added cognitive benefits. He emphasizes bright morning light and darkness at night for circadian strength, notes optic-flow/nature exposure as helpful but not required, and says electrolytes/salt needs are individual. The conversation covers cognitive decline and bioenergetics/mitochondria, critiques "type 3 diabetes" as oversimplified, reviews mixed evidence for ketones, and addresses supplements (omega-3s, vitamin D, saffron, creatine, polyphenols). Screens can help or harm depending on use and what they displace. Wood promotes his book, "The Stimulated Mind," out March 24.
Dr. Tommy Wood is a physician-scientist and brain health expert who helps people better understand how to improve cognition, protect memory, and reduce long-term dementia risk. With a focus on exercise, sleep, nutrition, and brain energetics, he explores the practical habits that support focus, processing speed, recovery, and healthy cognitive aging. Dr. Wood is known for translating complex neuroscience into clear, actionable advice, while challenging oversimplified ideas around stimulants, supplements, and modern brain optimization. Through his research, speaking, and new book The Stimulated Mind, Dr. Wood teaches people how to create the right conditions for better brain function across the lifespan. His work empowers listeners to think of brain health as something trainable—shaped by movement, sleep, learning, and the quality of the inputs we give our minds every day.
Books & Main Episode Resources The Stimulated Mind Official book page: https://www.drtommywood.com/stimulated-mind Publisher page: https://www.penguinrandomhouse.com/books/751292/the-stimulated-mind-by-dr-tommy-wood/
Dr. Tommy Wood Official website: https://www.drtommywood.com/ Instagram: https://www.instagram.com/drtommywood/
Podcasts, People & Platforms The Diary of a CEO Official show page: https://stevenbartlett.com/doac/ Joe Rogan Experience Official site: https://www.joerogan.com/ Spotify show page: https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk
Dr. Rhonda Patrick / FoundMyFitness Official site: https://www.foundmyfitness.com/ About Dr. Rhonda Patrick: https://www.foundmyfitness.com/about-dr-rhonda-patrick
Medications & Prescription Drugs Mentioned Provigil (modafinil) DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e16c26ad-7bc2-d155-3a5d-da83ad6492c8 Vyvanse (lisdexamfetamine) DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Concerta (methylphenidate) Official prescribing info: https://www.jnjlabels.com/package-insert/product-monograph/prescribing-information/CONCERTA-pi.pdf Adderall DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81 Adderall XR DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0 Aricept (donepezil) FDA label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020690s042,021720s014,022568s011lbl.pdf Hydration / Electrolytes LMNT Official site: https://drinklmnt.com/
Research, Labs & Studies Mentioned
COSMOS Trial Official site: https://cosmostrial.org/ ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT03035201
Institute for Human and Machine Cognition (IHMC) Official site: https://www.ihmc.us/
Jonathan Little Lab (UBC) Faculty page: https://hes.ok.ubc.ca/about/contact/jonathan-little/ Lab site: https://emil.ok.ubc.ca/
Show Notes 00:00 Stimulants Backfire 00:56 Plan Sleep First 02:33 Caffeine Timing 04:24 Brain Food Basics 05:12 Move All Day 06:00 Workouts That Help 07:26 Social Connection Matters 08:36 Sunlight Optic Flow Hydration 13:31 Exercise Types Compared 16:02 HIIT Lactate Brain Boost 18:18 Open Skill Sports 21:45 ADHD Meds Long Term 26:51 Which Med Is Best 27:59 Cognitive Decline Energy 28:27 Brain Energy Risk Factors 29:04 Stimulus Drives Brain Health 30:57 Type Three Diabetes Debate 33:42 Ketones and Cognition 37:13 Mitochondria and Decline 38:42 Omega Three Practical Dosing 41:45 Vitamin D and Dementia Risk 43:13 Saffron Hype Check 45:03 Creatine for the Brain 50:28 Polyphenols Diet vs Pills 52:41 Screens AI and Brain Use 55:31 Book Plug and Wrap Up
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #214 Optimal Nutrition: Fiber's Impact on Glucose and Cholesterol | 05 Mar 2026 | 00:29:27 | |
The script explains why fiber is critical for gut and metabolic health, focusing on how soluble fiber is fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate). It contrasts soluble fiber (forms a gel, lowers LDL by binding bile acids, slows glucose absorption, increases satiety, feeds the microbiome) with insoluble fiber (adds stool bulk, helps constipation). It highlights research showing 10 g/day psyllium husk (Metamucil) is linked to a 10% reduction in all-cause mortality and typically lowers LDL about 7–15%. Butyrate is emphasized as the primary fuel for colonocytes, supporting gut barrier integrity and potentially reducing colon cancer risk, while also affecting mitochondria, inflammation, and the brain. Propionate influences liver cholesterol production and satiety hormones, and acetate provides systemic energy. Practical supplementation "stacks," dosing ranges, food sources, GI side effects, and timing cautions (e.g., separating psyllium from minerals) are discussed.
Metamucil (psyllium husk fiber) — https://www.metamucil.com/
Psyllium husk (soluble fiber) — https://medlineplus.gov/druginfo/meds/a601104.html Psyllium husk (PubMed search) — https://pubmed.ncbi.nlm.nih.gov/?term=psyllium+husk
Soluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html Insoluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html
Inulin (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=inulin+prebiotic+fiber
Acacia fiber / Gum arabic (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=acacia+fiber+gum+arabic+prebiotic
Beta-glucan (oats/barley soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=beta-glucan+oats+LDL
Pectin (soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=pectin+soluble+fiber
Partially hydrolyzed guar gum (PHGG) — https://pubmed.ncbi.nlm.nih.gov/?term=partially+hydrolyzed+guar+gum
Resistant starch / Potato starch — https://pubmed.ncbi.nlm.nih.gov/?term=resistant+starch+potato+starch
Short-chain fatty acids (SCFAs) — https://www.ncbi.nlm.nih.gov/books/NBK557571/
Butyrate (SCFA) — https://pubmed.ncbi.nlm.nih.gov/?term=butyrate+short-chain+fatty+acid+colonocytes
LDL cholesterol (general) — https://medlineplus.gov/cholesterol.html
Magnesium (mineral supplement info) — https://medlineplus.gov/magnesium.html
Show Notes
00:00 Butyrate and Colon Health 00:49 Why Fiber Matters Now 02:28 How Fiber Is Digested 03:45 Soluble vs Insoluble Fiber 06:36 Gel Effect on Blood Sugar 07:36 How Soluble Fiber Lowers LDL 10:19 Short Chain Fatty Acids 101 11:32 Butyrate Deep Dive 16:40 Propionate and Liver Benefits 18:22 Acetate for Energy and Appetite 19:29 Best Fibers to Supplement 21:33 Dosing and Food Sources 24:44 Ideal Fiber Stack and Safety 28:37 Wrap Up and Next Steps
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #213 Emotions, Mind Control, and Mental Health Labels: A Conversation with Dr. Roger McFillin | 26 Feb 2026 | 01:02:08 | |
Dr. Roger McFillin argues that Western allopathic medicine and psychiatry have medicalized normal human suffering by reducing emotions to biological or chemical reactions, turning symptom checklists into fixed identities, and sustaining a drug-driven "sick care" system that creates lifelong customers. He contrasts this with viewing emotions as powerful energy meant to be moved into creation and transformation, cites psychoneuroimmunology, and warns that suppressing fear and distress with pharmaceuticals can worsen long-term outcomes. The conversation covers exposure-based approaches to unlearn fear, the role of media, social media, and advertising in provoking fear and keeping people in an unconscious "drift" state, and the importance of intentional stillness, solitude (distinct from loneliness), prayer or silent meditation, and reducing phone use—especially at the start of the day—to become more conscious and intentional.
McFillin discusses how diagnostic labels like depression and anxiety shape identity, limit choices, and contribute to chronicity and polypharmacy. He contrasts PTSD with post-traumatic growth, emphasizing processing trauma memories, facing avoided situations, challenging overgeneralized threat beliefs, and practicing forgiveness and self-compassion while also taking ownership where appropriate. They also discuss the perceived harms of the "toxic masculinity" concept, men's wellbeing, the loss of wise elders, and how men often bond and cope through shared activities. Dr. Roger McFillin is a clinical psychologist and trauma recovery expert who challenges the medicalization of normal human emotions. With a focus on emotional resilience and personal growth, he specializes in exposure therapy and psychoneuroimmunology, exploring the connection between mind, emotions, and immune health. Dr. McFillin advocates for self-regulation and transforming emotional energy into healing, critiquing the overuse of pharmaceuticals in modern mental health treatment. Through his Substack, Radically Genuine, and podcast, Dr. McFillin educates individuals on overcoming fear, achieving stillness, and reconnecting with their true selves. His work empowers people to shift from a victim mindset to one of active growth, using trauma as a catalyst for resilience and positive change.
Science & Medicine
Psychoneuroimmunology
Overview & science (NIH): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130991/
Exposure Therapy
Wikipedia overview: https://en.wikipedia.org/wiki/Exposure_therapy
Cleveland Clinic explanation: https://my.clevelandclinic.org/health/treatments/25067-exposure-therapy
Anxiety & OCD exposure-based approaches (IOCDF): https://iocdf.org/about-ocd/treatment/erp/
Heart Coherence
HeartMath Institute overview: https://www.heartmath.org/heart-coherence/
Psychiatric Diagnosis & DSM
Critique of DSM and diagnostic categories: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195174/
Psychiatric diagnosis controversies: https://www.apa.org/monitor/2013/04/diagnosis
Psychology & Healing
Post-Traumatic Growth vs. PTSD
Scientific overview of post-traumatic growth: https://www.apa.org/monitor/2014/01/psychological-recovery
Journal article on PTG vs PTSD: https://www.sciencedirect.com/science/article/abs/pii/S0272735814000412
Forgiveness and Healing
Psychology Today on forgiveness: https://www.psychologytoday.com/us/basics/forgiveness
Research evidence on forgiveness and wellbeing: https://journals.sagepub.com/doi/10.1177/1745691614568356
Self‑Healing Practices
Grounding / Earthing
What is grounding/earthing? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/
PEMF (Pulsed Electromagnetic Field) Therapy
Basics of PEMF therapy: https://www.health.harvard.edu/pain/pulsed-electromagnetic-field-therapy
Meditation & Stillness
Mindfulness & stillness research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422583/
Psychology Today on solitude and healing: https://www.psychologytoday.com/us/blog/hide-and-seek/201209/finding-solitude-its-benefits-and-challenges
Cultural & Media Influence
Mind Control & Fear Provocation
The psychology of fear in media messaging: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.566245/full
Media influence and persuasion research: https://www.communicationtheory.org/agenda-setting-theory/
Toxic Masculinity
Research overview on toxic masculinity: https://www.apa.org/advocacy/health-men/guidelines
What toxic masculinity means: https://www.psychologytoday.com/us/blog/the-masculine-mind/201802/what-toxic-masculinity
Dr. Roger McFillin Content
Substack (Radically Genuine): https://drmcmillan.substack.com
Show Notes 00:00 Emotions as Energy 00:33 Medicalizing Suffering 02:44 Exposure Beats Suppression 05:18 Fear and Mind Control 10:21 Stillness vs Loneliness 14:47 Simple Stillness Practices 20:12 Morning Intention Rituals 25:56 Labels and Identity Traps 31:26 Systemic Treatment Harm 32:53 Depression Label Identity 35:08 Sadness Versus Pathology 36:10 PTSD And Growth 38:24 Processing Trauma Fully 41:44 Practical Recovery Steps 45:48 Forgiveness And Ownership 50:37 Toxic Masculinity Debate 56:12 Men Friendship And Elders 01:01:05 Closing Plugs Farewell 38:24 How PTSD Develops 41:44 Practical Trauma Recovery 45:48 Forgiveness and Ownership 50:37 Toxic Masculinity Debate 56:12 Male Friendship and Elders 01:01:05 Closing and Where to Follow
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #212 Cialis as a Potential Longevity Drug: Vascular, Heart, Metabolic, and Brain Benefits | 19 Feb 2026 | 00:25:46 | |
This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.
The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.
Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.
Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)
Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)
Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)
Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)
Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)
Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)
Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)
Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)
People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)
Show Notes
00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #211 Understanding the Anti-Aging Benefits of Telmisartan | 12 Feb 2026 | 00:29:31 | |
In this podcast episode, an in-depth discussion is provided on the drug Telmisartan, commonly used for lowering blood pressure. The host elaborates on how it belongs to a class of medications known as angiotensin receptor blockers (ARBs) and stands out due to its 24-hour half-life and partial PPAR-gamma agonist activity. The episode explores Telmisartan's potential benefits for longevity, including its properties that reduce cardiovascular mortality, renal decline, and metabolic issues. It also compares Telmisartan with other ARBs and addresses its unique ability to improve myocardial efficiency, reduce arterial stiffness, and support neuroprotection. Detailed explanations are given on technical concepts such as pulse pressure and its relevance to arterial compliance, and the necessity to consult a doctor before taking the medication is emphasized.
Telmisartan / ARBs (main topic) Key mechanisms mentioned Angiotensin / aldosterone / "fight-or-flight" Lab tests mentioned in the episode Arterial stiffness / pulse pressure (longevity framing) Visceral fat resource mentioned
Show Notes
00:00 Welcome to the Hart2Heart Podcast. 01:22 Understanding Angiotensin and Its Effects 02:14 How ARBs Work and Their Benefits 03:00 Unique Properties of Telmisartan 03:36 Comparing Telmisartan with Other ARBs 04:44 Telmisartan's Impact on Endurance and Fat Loss 05:59 Telmisartan and Cardiovascular Health 09:57 Blood Pressure Basics and Pulse Pressure 18:54 Telmisartan's Role in Longevity and Dosing 27:28 Conclusion and Final Thoughts
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #210 A Personal Journey: My Decision to Quit THC | 29 Jan 2026 | 00:34:15 | |
In this podcast episode, the speaker shares his personal journey of quitting THC, explaining his reasons, the gradual process over several years, and the impacts on his life. He recounts his history with THC, from early recreational use to daily dependence for sleep aid during medical school and residency. The speaker emphasizes that he does not oppose cannabis, recognizing its medicinal value, but wanted to overcome his dependency. He details his method of reducing THC use through vaping and CBD alternatives, ultimately leading to his last use in January 2025. Alongside his personal story, he discusses the benefits and potential negative impacts of THC and other cannabinoids, offering insights into who might consider quitting and why.
Cannabis, THC & Quitting Cannabis (Marijuana) — NIDA overview: https://nida.nih.gov/research-topics/cannabis-marijuana Cannabis Use Disorder — NCBI Bookshelf (StatPearls): https://www.ncbi.nlm.nih.gov/books/NBK538131/
Sleep, REM & Withdrawal Cannabis and sleep architecture — systematic review (PubMed): https://pubmed.ncbi.nlm.nih.gov/40967124/ Effects of cannabinoids on sleep — review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC8116407/
Non-Intoxicating Cannabinoids Mentioned CBD + anxiety — systematic review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11595441/
CBG — acute effects + cognition (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11246434/ THCV — overview/commentary (PubMed): https://pubmed.ncbi.nlm.nih.gov/33526143/ CBC — therapeutic potential review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11493452/
Potency: Concentrates Marijuana Concentrates — NIDA DrugFacts PDF: https://nida.nih.gov/sites/default/files/df-marijuana-concentrates.pdf
Supplements Mentioned Omega-3 Fatty Acids — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/ Vitamin D — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/VitaminD-Consumer/
Show Notes 00:00 Introduction: Why I Quit THC 02:18 My History with THC 06:10 Transition to Medical Use 13:53 The Quitting Process 20:11 Benefits and Challenges of Quitting 25:07 Thoughts on THC and Other Cannabinoids 33:25 Conclusion and Final Thoughts
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart
| |||
| #209 Advanced Healing and Prevention Techniques with Stem Cells and Peptides | 22 Jan 2026 | 01:06:11 | |
Most people think they go into your body and make all new tissue… but in actuality, they are a delivery mechanism of growth factors. I call them the ultimate traffic cop. In this episode, the host converses with Dr. Jesse Morse, a physician specializing in regenerative and anti-aging medicine. They delve into the intricacies of stem cells and their various sources, including bone marrow, fat, and donor tissue. Dr. Morse highlights the role of exosomes and growth factors in the healing process. The discussion also focuses on the prevention and treatment of Achilles tendon tears, emphasizing the importance of blood supply, proper diagnosis, and innovative therapies. Additionally, they explore the benefits and applications of various peptides, including BPC 157, TB 500, and MotC, for enhancing healing, anti-aging, and overall health. Dr. Morse also addresses the significance of nutrition and detoxification in maintaining optimal health and preventing injuries. Linktree (aggregated links to socials & resources): https://linktr.ee/DrJesseMorse Supplements, Compounds & Peptides Collagen (protein / connective tissue support): Vitamin C (collagen activation / antioxidant): Creatine (muscle & mitochondrial support): BPC-157 (peptide – tendon & gut healing): TB-500 / Thymosin Beta-4 (peptide – tissue repair): GHK-Cu (copper peptide – skin, joints, stem-cell signaling): MOTS-c (mitochondrial peptide): SS-31 / Elamipretide (mitochondrial peptide): Thymosin Alpha-1 (immune modulation peptide): LL-37 (antimicrobial / immune peptide): 5-Amino-1MQ (NNMT inhibitor / fat loss): N-Acetylcysteine (NAC – liver & detox support): Glutathione (antioxidant / detox): NAD⁺ / NMN / NR (mitochondrial & anti-aging support): PRP – Platelet-Rich Plasma: Bone Marrow–Derived Stem Cells (BMAC): Adipose-Derived Stem Cells: Amniotic / Placental Tissue Products: Exosomes (cell signaling vesicles): Ultrasound-Guided Injections: Needle Tenotomy (scar-tissue disruption): Sauna (heat detox & cardiovascular benefit): Binders – Modified Citrus Pectin: GI Detox / Toxin Binders (general concept): Heavy Metal Chelation (DMPS concept): Mercury Toxicity: Microplastics in Humans: EBOO Therapy (ozone-based blood filtration): Therapeutic Plasma Exchange (TPE): INUSpheresis (advanced plasma filtration): Medications & Drug Classes Mentioned Corticosteroids (Prednisone – tendon risk): Fluoroquinolone Antibiotics (tendon rupture risk): GLP-1 Agonists (Semaglutide / Tirzepatide / Retatrutide discussion): Protein Intake & Muscle Health: American Gluten vs European Wheat: Seed Oils & Inflammation (discussion topic): Dairy & Inflammation (contextual mention): Poor Blood Supply in Achilles Tendon (Watershed Zone): Mitochondrial Dysfunction & Aging: Stem Cells as "Medicinal Signaling Cells":
Show Notes 00:00 Introduction to Exosomes and Stem Cells 01:01 Dr. Morse's Background and Transition to Regenerative Medicine 02:03 Achilles Tendon Tears: Causes and Prevention 05:02 Preventative Measures and Treatments for Achilles Injuries 10:26 The Role of Nutrition in Tendon Health 12:53 Peptides and Their Impact on Tendon Health 15:50 Stem Cells: Misconceptions and Applications 20:52 Comparing Stem Cell Sources and Their Potency 29:52 The Controversy of International Stem Cell Treatments 34:04 Cleaning Toxins from Your Blood 34:19 The Toxic Burden in Our Environment 35:57 Practical Detox Methods 37:47 Mercury and Heavy Metal Testing 44:47 The Problem with American Gluten 46:49 Underrated Peptides for Health 53:42 Growth Hormone and Anti-Aging 01:03:34 Advanced Blood Cleaning Techniques 01:04:51 Conclusion and Contact Information
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #208 The Real Science Behind Detoxification: Liver, Kidneys, and Gut Health Explained | 15 Jan 2026 | 00:30:29 | |
Most "detox" advice focuses on cleanses and quick fixes — but real detoxification is a constant, biological process your body runs every day. In this solo episode, the host breaks down how detoxification actually works, starting with what counts as a "toxin" (including hormones and environmental chemicals) and how the body packages them for elimination. You'll learn the key roles of the liver, kidneys, and gut — and why detox can succeed in the liver but fail in the intestines, especially when certain gut bacteria produce enzymes like β-glucuronidase that can send toxins back into circulation. The episode covers major detox pathways (including glucuronidation), the importance of bile flow and regular bowel movements, and why fiber is one of the biggest levers you can pull to support elimination. It also explores how hydration, electrolyte balance, stress, and overtraining can influence detox capacity, plus the limited-but-real role sweating may play in clearing certain heavy metals. Finally, you'll get practical strategies for supporting a healthier gut microbiome and reducing toxin buildup — from diet and polyphenols to commonly discussed supplements like NAC, glycine, and taurine.
Supplements & Compounds Magnesium (supplement/mineral): Zinc (supplement/mineral): Psyllium (fiber / bulk-forming laxative): Spirulina (supplement / "blue-green algae"): Activated Charcoal (binder / poisoning use): Glycine (amino acid): N-Acetylcysteine (NAC): Foods / Gut & Microbiome Mentions Fermented foods (kimchi, sauerkraut, etc.): Kimchi (specific fermented food mentioned): Sourdough (food example mentioned): Berries (food example mentioned): Wild rice (food example mentioned): Medications Mentioned Ibuprofen (Advil): Naproxen (NSAID): Lifestyle / Modalities Mentioned Sauna: Infrared sauna: Red light therapy (photobiomodulation): Environmental / Exposure Topics Mentioned BPA (bisphenol A): Phthalates: Lead exposure: Arsenic in rice: Key Mechanism/Concept Mentioned Gut microbial β-glucuronidase (and "glucuronidation" talk):
Show Notes 00:00 Introduction to Detoxification 02:00 Understanding Toxins and Hormones 05:36 Common Environmental Toxins 07:10 The Detoxification Process 10:52 Gut Health and Detoxification 20:07 Sweating and Detoxification 23:35 Supplements for Detoxification 29:31 Conclusion and Final Tips
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart
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| #207 Mastering Hydration: The Essential Guide to Water, Electrolytes, and Optimal Performance | 08 Jan 2026 | 00:31:07 | |
What if your "healthy" water intake is still quietly hurting your performance? In this solo episode, Dr. Mike breaks down hydration from a performance-first perspective — how dehydration affects cognition and physical output, why "8 glasses a day" is an oversimplified myth, and how to personalize your intake based on body size, activity level, diet, environment, and medications. He walks through practical guidelines (including 30–35 ml/kg/day), how to use urine + thirst cues without overcomplicating it, and why timing matters (especially around workouts, sauna use, and sleep). A major focus of this episode is electrolytes — what they do, how sweat changes your needs, and why sodium is often the key limiter for athletes, sauna users, and people eating low-carb/keto. Dr. Mike also covers potassium and magnesium, caffeine and hydration, the risks of overhydration, and the classic warning signs of hyponatremia. This is a comprehensive, no-BS guide to staying hydrated, replenishing electrolytes correctly, and improving energy, performance, and sleep.
Resources: Electrolyte & Hydration Products
Medical / Health Conditions & Guidance
Lab Tests
Mineral / Supplement References
People / Sources Mentioned
Show Notes 00:00 Welcome Back to the Hart2Heart Podcast! 00:55 The Importance of Hydration 01:46 Daily Water Intake Guidelines 04:16 Sweat and Electrolyte Loss 06:56 Sodium: The Key Electrolyte 12:22 Potassium: Essential for Muscle and Heart Health 15:20 Magnesium: The Multi-Functional Mineral 20:08 Other Important Nutrients 22:33 Hydration Strategies and Special Populations 26:37 Final Tips and Conclusion
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart | |||
| #206 How to Fix High Blood Pressure (Without Guessing) | 02 Jan 2026 | 00:37:13 | |
In this solo episode, Dr. Mike breaks down everything you need to know about blood pressure, why it's so commonly misunderstood, how to measure it correctly, and what optimal numbers really look like. He explains why 120/80 isn't ideal for everyone, why blood pressure variability can be more dangerous than steady high readings, and how sleep, stress, and undiagnosed sleep apnea quietly drive hypertension. The episode walks through a clear, practical framework for managing blood pressure using lifestyle interventions first, followed by supplements, and medications only when necessary. Dr. Mike covers exercise, weight loss, sodium and potassium balance, magnesium, breathing techniques, sauna use, sleep optimization, and evidence-based supplements like olive leaf extract, beetroot, citrulline, and nattokinase. He also explains when medication is appropriate, why ARBs are often preferred, and which drugs can interfere with exercise performance. This is a comprehensive, no-BS guide to protecting your heart, brain, kidneys, and long-term health.
Blood Pressure & Monitoring
Sleep Apnea & Blood Pressure
Supplements Discussed
Medications (General Reference)
Show Notes 00:00 Welcome to the Hart2Heart Podcast. 02:15 Why 120/80 isn't optimal for everyone 04:15 What actually causes blood pressure to fluctuate 06:40 Why BP variability is more dangerous than steady high BP 07:30 How to measure blood pressure correctly at home 12:45 Nighttime BP, dippers vs non-dippers (and why it matters) 14:00 Sleep apnea: the hidden driver of hypertension 18:30 The lifestyle changes that lower BP the most 21:00 Electrolytes, magnesium, and nervous system control 26:00 Supplements that actually move the needle 31:25 When medication becomes necessary (and when it doesn't) 36:20 The long-term blood pressure strategy most people miss
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box physicians and researchers to public health experts and high-profile thinkers focused on real solutions. If you're ready to take control of your health and performance, this podcast is for you. Connect with Dr. Mike Hart Instagram: @drmikehart
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| #205 Stop Nighttime Peeing | 25 Dec 2025 | 00:40:44 | |
In this solo episode, Dr. Mike discusses the common issue of nocturia, where individuals frequently wake up at night to urinate, which disrupts sleep. The episode covers the root causes including sleep apnea, enlarged prostate, and overactive bladder, and dives into the roles of antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP). It provides a comprehensive guide on addressing nocturia through behavioral modifications such as fluid restriction and sleep hygiene, supplements like pumpkin seed extract and beta-sitosterol, and pharmaceuticals including Desmopressin and alpha-blockers. The host also touches on treating sleep apnea with CPAP machines and mandibular advancement devices, emphasizing the importance of targeting the root cause for effective treatment.
Links: CPAP (Continuous Positive Airway Pressure) Beta-Sitosterol Desmopressin (Synthetic ADH)Show Notes: 00:00 Understanding nocturia and its connection to sleep apnea 01:00 Introduction and episode overview 02:00 Defining nocturia and its impact on sleep 03:00 Types of nocturia and their causes 04:30 The role of hormones in nocturia 05:30 Sleep apnea and its effects on nocturia 15:30 Behavioral modifications to reduce nocturia 24:00 Supplements for managing nocturia 30:00 Pharmaceutical solutions for nocturia
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #204 Resetting Dopamine for Monogamy | 11 Dec 2025 | 00:28:39 | |
In this solo episode, Dr. Mike delves into the complex relationship between dopamine, romantic relationships, and the Coolidge Effect. The discussion highlights why men often feel the need for a new partner due to a desensitization of dopamine and how our overstimulated lifestyles contribute to this issue. The host explores the impact of modern habits on dopamine levels, the importance of boredom for resetting dopamine sensitivity, and the role of anticipation in maintaining desire. Practical solutions like dopamine resets, engaging in effort-based activities, and ensuring personal growth and solitude are discussed as ways to improve both individual well-being and relationship satisfaction. Links: The Dopamine Collapse Hypothesis: Foundations of Macro-Neuroeconomics
Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 01:30 Understanding the dopamine cycle 03:30 Daily habits and dopamine desensitization 09:00 The Coolidge effect and relationship dynamics 15:00 Dopamine resets and effort-based activities 22:00 Reviving desire in long-term relationships28:38 "Our nervous system never gets any time to recover—and that kills desire."
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #203 Rethinking 10k Steps | 04 Dec 2025 | 00:26:07 | |
In this episode, Dr. Mike Hart delves into the origins and contemporary relevance of the 10,000 steps rule. He discusses the latest research outcomes from a massive meta-analysis comparing daily step counts from 2,000 to 12,000 steps and their associated health benefits. Listeners will learn about the significant reductions in mortality, cardiovascular disease, cancer mortality, dementia, depression, and type 2 diabetes risk achieved by increasing daily steps. The episode also provides insights into the importance of breaking up sedentary periods, the physiological differences between various forms of steps, and practical tips for incorporating more steps into daily routines, even for office workers.
Links: Massive Steps Meta-analysis
Show Notes: (00:00) Welcome back to the Hart2Heart Podcast with Dr. Mike Hart (01:30) Origins of the 10,000 steps rule (03:00) Latest research on step counts(06:34) "Each 1,000 steps lowers your chance of depression by about 9%." (08:00) Steps vs. exercise: understanding the difference (21:30) Practical tips for increasing daily steps
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #202 Better Alternatives To Metformin | 28 Nov 2025 | 00:21:32 | |
In this solo episode, the host discusses the effects of metformin, berberine, and dihydroberberine on exercise adaptation and longevity. While metformin is known for its longevity benefits and is popular in the biohacking community, it has been shown to significantly reduce exercise adaptations and VO2 max gains. Berberine, a supplement with similar effects to metformin, is easier to obtain but still has some negative effects on exercise and significant GI side effects. The episode introduces dihydroberberine (DHB), a compound with fewer GI issues and less impact on exercise adaptation, making it more suitable for athletes. The host explains the mechanisms behind these compounds, including their effects on AMPK and mTOR pathways, and offers practical advice on when to take DHB in relation to different types of exercise to maximize benefits and minimize drawbacks.
Links: Harvard longevity researcher known for NAD+ & aging research. Diabetes drug often discussed for longevity.
Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:14 "Metformin may blunt up to 50% of your VO₂ max gains — that's a massive hit for any athlete." 00:30 Metformin: the popular longevity drug 01:00 Berberine: the over-the-counter alternative 02:30 Understanding AMPK and mTOR 04:30 Metformin's mechanism and drawbacks 06:00 Berberine's mechanism and side effects 07:30 Dihydro berberine: the superior choice 10:30 DHB and exercise: timing and benefits 18:00 Comparing Metformin, berberine, and DHB
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #201 Building True Mental Toughness with Tony Ricci | 20 Nov 2025 | 01:08:03 | |
In this episode of the Heart to Heart podcast, Dr. Mike Hart chats with Tony Ricci, an athletic performance and mental health coach for athletes. Tony shares his fascinating journey from studying exercise physiology to working with elite athletes like MMA fighter Chris Weidman. They discuss the critical impact of mental resilience on athletic performance, practical strategies for mental and physical training, and bridging the gap between nutrition, conditioning, and mental skills training. Additionally, the conversation touches on the role of technology like HRV and sleep tracking in athlete performance, effective supplement strategies, and the nuanced benefits of practices like cold plunges and saunas. Tony also reflects on adjustments he has made in his training approach over the years to avoid overtraining fighters.
Tony Ricci is a veteran performance coach and sport scientist specializing in the intersection of strength training, nutrition, and mental performance for combat athletes. With a background spanning exercise physiology, sports science, and nutrition—as well as decades of hands-on coaching—Tony has trained world-class fighters and helped shape modern approaches to MMA preparation. Connect with Tony on Instagram at sportpsy_sci_doc or at tony@fightshape.net
Links:
Show Notes: 00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart 00:30 Tony Ricci's background in athletic performance 02:00 The importance of mental performance in sports 04:30 Strategies for mental resilience in athletes 09:00 Psychological resilience and childhood experiences 13:02 "Yes, you can still build mental toughness without trauma. Many champions had good parents, good support, and still developed world-class grit." 14:30 Discipline: self-trained vs. innate 18:00 Using technology to monitor athlete performance 31:30 Handling poor sleep before a big fight 33:30 The role of caffeine in training camps 35:30 Creatine usage and dosage 37:30 Recommended supplements for athletes 39:30 Beta-alanine and its benefits 43:30 Exploring other supplements: beetroot, HMB, and Alpha GPC 48:00 Exogenous ketones and ketogenic diets 54:00 The benefits of cold plunges and saunas 58:00 Evolving training methods for fighters 01:00:30 Optimizing cardio training for fighters
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #200 Rethinking LDL and Longevity with Greg Mushen | 13 Nov 2025 | 01:01:36 | |
In this episode of the Heart to Heart Podcast, Dr. Mike Hart sits down with Greg Mushen, a former tech professional turned health advocate, to discuss his incredible journey of transforming his body and lifestyle. Greg shares insights from his background growing up in a medical family and how early exposure to health experiments sparked his long-lasting interest in nutrition and fitness. He details his significant body transformation starting at age 47, the role of tracking macros and engaging in strength training, and the importance of key habits like walking 17,000 steps a day. The conversation also delves into the use of red light therapy, the science behind resistant starches, and maintaining a balanced routine without becoming overly dependent on health gadgets. Greg's shift from a tech-centric life to a health-focused one offers valuable lessons on maintaining physical and mental wellness.
Greg Mushen is a tech veteran turned health optimizer, fitness coach, and writer whose work explores the science of sustainable transformation, metabolic health, and longevity. After a two-decade career in technology, Greg redirected his analytical mindset toward understanding how data-driven habits and consistent routines can radically improve health and well-being. Connect with him on LinkedIn at @GregMushen.
Links:
Show Notes: 00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart 01:00 Greg's early interest in health 02:30 The turning point: realizing the need for change 03:30 Greg's transformation and Twitter journey 04:30 Key strategies for transformation 08:00 The importance of walking and daily steps 10:00 Sustaining the transformation: tools and tips 14:23 "At first, tracking my food felt like a second job. But after six weeks, it became automatic—it stopped being effort and started being just who I am." 18:30 Mindset shifts and progress tracking 22:30 The role of LDL in health 27:00 Calories in, calories out debate 30:00 Accurate weight prediction and metabolic studies 31:00 Challenges of calorie tracking and satiation 32:00 Dr. Ted Naman's approach to calorie tracking 33:00 Impact of drinking calories and fiber intake 35:00 Complex carbs and resistant starch 41:00 Benefits of red light therapy 45:30 Nicotine use and addiction 49:00 Tech background and health experimentation 53:30 Future health technologies and personal insights
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #199 How to Train Like a Pro Fighter with Dr. Corey Peacock | 06 Nov 2025 | 00:54:48 | |
In this episode of the Heart to Heart podcast, Dr. Mike Hart interviews Dr. Corey Peacock, an exercise physiologist and department chair at Nova Southeastern University. Dr. Peacock discusses his diverse background, from establishing the Fight Science Laboratory to working with elite MMA fighters at Kill Cliff Fight Club. The conversation covers advanced training methods, including zone-based cardio, strength and conditioning exercises, and recovery protocols. Listeners gain insights into the importance of athletic balance, the role of power versus strength in MMA, and the efficacy of various recovery tools such as cold plunges, sauna, and red light therapy. Dr. Peacock emphasizes the tailored approach needed for different fighters and the benefits of continually evolving training strategies.
Dr. Corey Peacock is an exercise physiologist, sports scientist, and performance coach who bridges academic research with elite MMA training. He holds a Ph.D. in Exercise Physiology from Kent State University and serves as Department Chair of Health and Human Performance at Nova Southeastern University, where he co-founded the Fight Science Lab. As Director of Athlete Performance for Kill Cliff Fight Club, Dr. Peacock helps world-class fighters optimize strength, endurance, and recovery through science-driven performance methods. Connect with him on Instagram @drcpeacock and LinkedIn. Links: American College of Sports Medicine (ACSM) Kill Cliff Fight Club (formerly Blackzilians and Sanford MMA) Dr. José Antonio – Co-founder of Fight Science Lab
Show Notes: 00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart 00:47 Dr. Corey Peacock's Background 02:52 Cardio Training for MMA Fighters 17:41 Strength and Conditioning Essentials 30:35 Reverse Hypers and Posterior Chain Training 34:17 Balancing Strength and Power in MMA 36:44 Training Insights from Anthony Rumble Johnson 42:42 The Role of HRV in Training Adjustments 47:13 Recovery Tools: Cold Plunges, Sauna, and Red Light Therapy 52:57 Upcoming Events and Contact Information
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #198 How to Reverse Insulin Resistance | 30 Oct 2025 | 00:32:54 | |
In this solo podcast episode, Dr. Mike Hart delves into the intricacies of insulin resistance, a prevalent yet misunderstood condition. The episode covers the fundamental role of insulin, what happens during insulin resistance, and its linkage to various diseases like diabetes and heart disease. It includes a detailed discussion on how to measure insulin resistance using markers like triglyceride to HDL ratio, fasting insulin, fasting glucose, and hemoglobin A1c. Dr. Hart also explains the significance of advanced glycation end products (AGEs) and how they contribute to aging and diabetes. Practical tips on improving insulin sensitivity through diet, exercise, and supplements such as fiber, mulberry leaf extract, and berberine are provided. Additional considerations for managing blood sugar levels and preventing insulin resistance are also discussed.
Links: Fasting Insulin Test: https://medlineplus.gov/lab-tests/insulin-in-blood/ Fructosamine Test: https://medlineplus.gov/lab-tests/insulin-in-blood/ Carnosine: https://examine.com/supplements/carnosine/?show_conditions=true P5P (Pyridoxal-5-Phosphate): https://examine.com/supplements/vitamin-b6/?show_conditions=true
Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:56 Understanding Insulin and Insulin Resistance 03:02 Markers and Tests for Insulin Resistance 11:30 Advanced Glycation End Products (AGEs) 14:16 Exercise and Insulin Sensitivity 14:53 "Exercise keeps your body insulin sensitive for up to 48 hours — not just two." 16:21 Nutritional Strategies for Blood Sugar Control 20:59 Supplements and Medications for Blood Sugar Management
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #197 Why Your Brain Needs Friends with Dr. Ben Rein | 23 Oct 2025 | 01:11:12 | |
In this episode, host Dr. Mike Hart welcomes neuroscientist and author Dr. Ben Rein to discuss his new book, 'Why Brains Need Friends: The Neuroscience of Social Connection.' Dr. Rein shares his journey in neuroscience, his research on autism and MDMA, and his pivot towards science communication. They delve into the devastating effects of loneliness, comparing its impact on mortality to smoking 15 cigarettes a day, and explore why human connections are critical for our brain health. Dr. Rein also discusses the benefits of having pets, the intricate balance of social interactions across a lifespan, the effects of MDMA on feelings of connection, and the role of oxytocin in social bonding. This episode provides a deep dive into the science behind social interactions, offering actionable insights to improve mental health and wellbeing.
Dr. Ben Rein is a neuroscientist, educator, and science communicator whose work explores the biology of human connection, empathy, and social behavior. With a Ph.D. in neuroscience and postdoctoral research at Stanford University, Dr. Rein has studied everything from the neural underpinnings of autism spectrum disorder to how MDMA (ecstasy) enhances empathy in the brain.
Follow his work at mindscience.org or connect with him on Instagram.
Links:
Show Notes: 00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart 00:30 Dr. Ben Rein's background and new book 02:30 The loneliness epidemic and its effects 04:00 The science behind social interaction 04:15 " Being isolated is worse for you or as bad for you as smoking 15 cigarettes a day." 10:30 Extroversion vs. introversion: social needs 24:00 Oxytocin: the love hormone 33:00 Teamwork and social bonds 36:30 The power of tribalism in sports 38:00 Romantic relationships and health 42:00 The impact of loneliness across a lifetime 49:00 Social media and loneliness 01:02:00 The therapeutic potential of MDMA
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #196 Rethinking Protein and Recovery with Dr. Jose Antonio | 16 Oct 2025 | 00:45:26 | |
In this episode of the Heart to Heart podcast, Dr. Mike Hart chats with Dr. Jose Antonio about the evolution and impact of sports nutrition research, particularly focusing on creatine and protein consumption. Dr. Antonio shares his journey from studying muscle physiology to pioneering research in sports nutrition, highlighting the initial skepticism in the scientific community and the eventual acceptance of supplements like creatine. They also delve into the benefits of various supplements for athletic performance, the ongoing debates in the medical field regarding supplementation, and exciting upcoming research on creatine's effects on eye muscle performance in athletes.
Links: Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:00 Introduction and guest welcome 01:00 Dr. Jose Antonio's academic journey 01:30 Challenges in sports nutrition research 04:00 Breakthrough in sports supplements 08:00 The evolution of sports nutrition 13:00 High protein diet studies 14:20 "We had people eating 600 to 800 extra calories of pure protein—and nothing happened. No fat gain. That alone blew people's minds." 17:00 Protein timing and intake 20:30 Impact of hormones on protein absorption 23:00 Testosterone and protein intake 24:00 Peptides and growth hormone 25:00 Protein timing and casein 25:30 Creatine for brain and muscle 42:00 Mitochondrial health and supplements
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #195 How to Eat for Satiety with Dr. Ted Naiman | 09 Oct 2025 | 01:15:50 | |
In this episode of the Heart to Heart podcast, Dr. Mike Hart sits down with Dr. Ted Naiman, a family medicine physician from Seattle with a passion for diet and exercise. They discuss the importance of family physicians in healthcare, Dr. Naiman's personal fitness transformation focusing on a high-protein, low-carb diet, and the significance of satiety over counting calories. Dr. Naiman shares his views on effective exercise routines, optimal macronutrient ratios, and the advantages of front-loading protein. They also delve into insulin resistance, the use of fasting triglycerides as a marker, and the potential of GLP-1 medications for weight loss and insulin sensitivity. This comprehensive discussion provides actionable insights into improving metabolic health and body composition.
Dr. Ted Naiman is a family physician, author, and leading voice in evidence-based nutrition and metabolic health. With over two decades of experience in primary care, Dr. Naiman has dedicated his career to helping people understand the science of body composition, satiety, and sustainable weight management. Learn more at tednaiman.com and on LinkedIn.
Links: Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:30 Dr. Ted Naiman's background 01:30 Transformation journey 02:00 Diet and exercise philosophy 03:00 Calorie counting debate 05:30 Macro ratios and protein focus 09:30 Daily meal timing and strategy 13:27 "Front-load your protein. If you start your day with donuts, you'll eat more all day. If you start with protein, you'll automatically eat less." 20:30 Sources of protein 25:00 Carbohydrate choices 29:00 Fat sources and supplementation 34:00 Understanding insulin resistance 37:30 Understanding insulin sensitivity and resistance 39:00 Indicators of insulin resistance: triglycerides and HDL 43:30 The role of fasting insulin and glucose 50:30 Training recommendations: cardio vs. weights 52:30 Effective resistance training strategies 59:30 Visceral fat: causes and reduction strategies 01:05:30 The role of GLP-1 in weight management 01:14:30 Conclusion and final thoughts
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #194 Unraveling Imposter Syndrome and Embracing Transformation Through Storytelling | Featuring Serena Choo | 02 Oct 2025 | 01:06:22 | |
In this episode of the Heart to Heart podcast, host Dr.Mike Hart welcomes author Serena Choo, who delves into her journey of writing and overcoming imposter syndrome. They discuss Serena's second book, 'The Monkey and the Way of Zen,' which contains 28 short Zen-inspired stories aimed at providing readers a relaxing and reflective experience. Choo shares insights into the origins of her work, the importance of letting go and subtracting complexities from life, and how personal transformation can be achieved without the burden of constant goal-setting. Additionally, they touch upon topics such as her career transition, the specifics of dealing with imposter syndrome, the concept of emotional intelligence, and the potential benefits of neurolinguistic programming (NLP).
Serena Choo is a transformation coach, author, and thought leader in personal growth and self-discovery. With over two decades of experience spanning corporate finance, executive coaching, and nutritional therapy, Serena has dedicated her career to helping people break free from self-doubt, imposter syndrome, and burnout. She is the author of Letting Go of Imposter Syndrome and The Monkey and the Way of Zen: A Transformation Journey in 28 Short Stories, books that blend practical wisdom with storytelling to inspire reflection, inner peace, and authentic living. Drawing from her background in executive coaching, functional medicine, and NLP, Serena's work emphasizes radical surrender, self-awareness, and creating fulfillment through subtraction rather than constant striving. Learn more about Serena at serenachoo.com
Links: Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:30 Discussing Serena's books 02:00 The inspiration behind 'the monkey and the zen' 02:00 Serena's writing journey 04:30 Finding nemo and storytelling 05:30 The essence of zen stories 06:00 Mike's reflection on reading 07:30 Goal setting and personal fulfillment 08:30 Serena's career background 10:00 Transition to coaching 17:00 Imposter syndrome explained 21:30 Techniques to overcome imposter syndrome 27:30 Changing thought patterns 31:30 The role of fortune and stoicism 33:30 Imposter syndrome and self-doubt 34:00 Personal anecdotes and overcoming challenges 38:00 Accepting compliments and authenticity 48:30 Emotional intelligence and reactions 48:50 "To me, emotional intelligence is first about understanding what's going on within yourself — not pushing away the feelings, but being aware of the programs running underneath." 55:30 Coaching differences between genders 01:00:30 NLP and its benefits
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #193 Debunking Health Myths and Optimizing Nutrition with Alex Leaf | 25 Sep 2025 | 01:13:11 | |
In this episode of The Heart to Heart podcast, host Dr. Mike Hart interviews Alex Leaf, an independent nutritional researcher renowned for debunking nutritional misinformation on social media. The discussion covers topics such as the benefits of collagen for skin health, the potential advantages of ketogenic diets for athletes, and the truth behind various nutrition myths including the effects of soy on testosterone and semen retention. Alex also shares his insights on intermittent fasting, ideal protein intake, and the debate over seed oils. The conversation concludes with their thoughts on cardiovascular health markers and the relevance of particle size in LDL cholesterol.
Alex Leaf is an independent nutritional researcher, scientific communicator, and educator specializing in human health and performance. With a decade of experience translating complex science into actionable insights, Alex rose to prominence as a researcher and writer at Examine.com before joining Ari Whitten's Energy Blueprint. His work spans peer-reviewed publications—including contributions to the ISSN position stand on ketogenic diets—and teaching in the Master's program in Human Nutrition and Functional Medicine at the University of Western States. Follow him here:
Links: Show Notes:
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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| #192 Exploring Modern Therapy: From Psychedelics to AI with Rav Arora | 11 Sep 2025 | 01:08:16 | |
In this episode of The Heart to Heart podcast, host Dr. Mike Hart welcomes back Rav, an author and host of the Illusion of Consensus podcast. The conversation delves into Rav's evolving interests, from his initial focus on COVID-19 and myocarditis to his current pursuit of a more holistic and spiritually grounded life. Rav discusses his journey through rigorous psychotherapy, aided by psychedelics, to uncover subconscious patterns and improve his overall well-being. The discussion also touches on the utility of AI tools like ChatGPT as supplementary therapy, the impact of social media on Gen Z's social behaviors, and the rising influence of independent journalism. The episode sheds light on finding balance in a hyper-productive world, integrating different therapeutic pathways, and the significance of peaceful presence in one's life.
Rav Arora is an independent journalist, cultural critic, and podcast host exploring the intersections of health, spirituality, and human performance. Rising to prominence through his widely read Substack, The Meta Mystic, and as co-host of The Illusion of Consensus podcast, Rav has become a leading voice challenging mainstream narratives in science, psychology, and culture. Follow him here: Links: Psilocybin & Religious Leaders Study Pain Reprocessing Therapy (PRT) Show Notes:
— The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.
Beyond health science, we tackle the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect on social with Dr. Mike Hart:
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