Explore every episode of the podcast Going anti-Viral
| Title | Pub. Date | Duration | |
|---|---|---|---|
| Must Listen Episode - Latest Update on Emerging Viral Infections and Current Public Health Threats | 18 Jan 2025 | 01:03:33 | |
This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," a panel discussion held on January 15, 2025. This IAS-USA Dialogue is a must listen as our distinguished panel of infectious diseases experts dives deep into some of the most pressing public health challenges facing the world today. Moderated by Carlos del Rio, MD, a Distinguished Professor of Medicine in the Division of Infectious Diseases at Emory University School of Medicine, this Dialogue brings together world-class experts Yvonne Maldonado, MD, Peter Chin-Hong, MD, and Jason Zucker, MD, to discuss the latest news on urgent and emerging viral outbreaks, including mpox, avian flu (H5N1), respiratory syncytial virus (RSV), measles, human metapneumovirus, and COVID-19/long COVID. The panel also reflects on the alarming erosion of public trust in public health experts, which has been compounded by misinformation and the long-term effects of the COVID-19 pandemic. 0:00 – Introduction 2:27 – Update on mpox including treatment options 11:09 – Discussion of avian flu (H5N1), influenza, and vaccination in human and animals 27:36 – Impact of avian flu (H5N1) on dairy and other agriculture industries and the role of public health in supporting the economy 32:47 – Impact of recent study on Tamiflu in treatment recommendations and discussion of Biloxivir 37:37 – Update on COVID-19 – vaccination, treatment with Paxlovid, other treatment options, and long COVID 48:27 – Recent updates on respiratory syncytial virus (RSV) and vaccination 52:03 – Discussion of human metapneumovirus 54:25 –Impact of misinformation on the reduction in measles vaccinations and the health risks of measles to the population at large __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 35 - Reflections on the Role of HRSA in the Care of People with HIV – Laura Cheever | 14 Jan 2025 | 00:32:48 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Laura Cheever who was, until recently, the Associate Administrator of the HIV/AIDS Bureau at the Health Resources and Services Administration (HRSA). She joined HRSA in 1999 when she served as the national director of the Ryan White AIDS Education and Training Center program. Dr Cheever is Board Certified in Infectious Diseases and continues to provide clinical care for patients with HIV. Dr Cheever describes her early work at HRSA and the Ryan White HIV/AIDS Program. Dr Cheever and Dr Saag then discuss quality measures adopted to demonstrate program effectiveness and the impact these efforts had on funding. They also discuss the staff in the program and their role in working with local providers. They address the role that private insurance, the Affordable Care Act, and different presidential administrations play in the services of the program as well as work left to be done and look ahead to the next ten years of HIV care. 0:00 – Introduction 1:40 – A discussion of Dr Cheever’s early years at the Health Resources and Services Administration (HRSA) 7:51 – Implementation of national quality measures for HIV care using data collection through CAREWare 11:41 – How did new information impact decision making regarding Ryan White funding decisions 15:04 – Impact of changing guidelines on direction given to the Ryan White clinics 19:26 – The staff at HRSA and the impact of potential budget cuts on the program 24:05 – The role private insurance and the Affordable Care Act had in providing treatment through the Ryan White program 25:10 – Do different presidential administrations influence the services of the Ryan White program 27:34 – Discussion of the work left to be done 29:29 – Predictions for the next ten years of HIV care and closing remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 26 - The Exploding Epidemic of Substance Use Disorder: What Can We Do? - Dr Sandra Springer | 24 Sep 2024 | 00:28:21 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Sandra Springer from the Yale School of Medicine about the substance use disorder epidemic. Dr Springer describes the history of the epidemic and the recent crisis of overdose deaths in the United States. She talks about the increase in overdose deaths since 1999 due to prescription opioids. Dr Saag and Dr Springer review how HIV practitioners can manage patients with substance abuse disorder, including a discussion of how to manage patients undergoing withdrawal. Finally, they address harm reduction strategies available to practitioners and new data showing a reduction in overdose deaths, providing long-term hope for the effectiveness of these strategies. But they note that more research, funding, and outreach is needed to meet the risks that opioid and non-opioid substances pose in the future. 0:00 – Introduction 1:22 – Magnitude of the substance use disorder epidemic 2:31 – Factors that led to the increase in deaths after 1999 3:54 – Background on widespread fentanyl use 5:22 – Impact of prescription opioids for chronic pain management on addictions 7:52 – HIV healthcare practitioners’ role in managing patients with substance use disorders 10:15 – Management of withdrawal, including long-term management options 18:33 – Harm reduction strategies and the use of naloxone to prevent overdose deaths 23:04 – Review of new data showing reduction in overdose deaths in the United States 24:19 – Closing remarks and expectations for the next 10 years IAS–USA resources on substance use disorders: -- MATE Act CME - https://www.iasusa.org/dea-compliant-cme-resource-center/ -- Fellow Resources: https://www.iasusa.org/fellow-student-resources/ __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 25 - What’s all this fuss about Bird Flu (Influenza A) – with Dr Andrew Pavia | 10 Sep 2024 | 00:34:56 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Andrew Pavia from the University of Utah about influenza A, specifically the H5N1 strain. Dr Pavia describes the progression of H5N1 and its recent impacts on poultry and other animal populations, including an overview of a recent outbreak among dairy cattle and whether there is a risk to humans exposed on farms and the milk supply at large. They discuss how influenza vaccines are determined each year and the timing of when best to recommend vaccination. They describe treatment options for influenza and their effectiveness against H5N1. Finally, they address public health measures taken during influenza outbreaks and the COVID-19 pandemic, offering lessons learned for future influenza outbreaks in humans. 0:00 – Introduction 1:32 – Overview of influenza 2:54 – Human susceptibility to influenza 5:20 –Types of influenza and evolution of H5N1 from birds to mammals 9:24 – Natural history of transmission in humans 12:34 – Current outbreak of H5N1 in dairy cattle and risk to the milk supply 16:48 – Overview of influenza vaccines and immunity 23:36 – Treatment options with onset of influenza symptoms and H5N1 is resistance 30:00 – Lessons learned from public health measures taken to protect against outbreaks of influenza and COVID-19 __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 24 - HPV and Anal Cancer: Vaccination and Screening in People with HIV - Dr Timothy Wilkin | 27 Aug 2024 | 00:27:14 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Timothy Wilkin from the University of California San Diego about the human papillomavirus (HPV) and anal cancer with options for screening, prevention, and vaccination. They provide an overview of HPV and the types of HPV that lead to cancer. They discuss screening and prevention for anal cancer at HIV and PrEP clinics. They also discuss the findings of the ANCHOR study that demonstrated that high-resolution anoscopy screening detects and prevents anal cancer caused by HPV. Finally, they review HPV vaccination, its effectiveness, and the challenges with uptake of the vaccine in the population at large. 0:00 – Introduction 1:32 – Overview of HPV 3:01 – HPV and cancer 4:43 – Screening and prevention for anal cancer at HIV and PrEP clinics 9:38 – Findings of the ANCHOR study – efficacy of high resolution anoscopy in detecting anal cancer caused by HPV. 11:32 – Barriers to screening and treatment 15:05 – HPV vaccination - recommendations and efficacy 18:10 – Challenges with HPV vaccination uptake 24:30 – Next ten years of HPV and closing remarks Resources and articles: Single dose HPV vaccine article __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 23 - New Long COVID Disability Guidelines - with Dr Paul Volberding | 13 Aug 2024 | 00:26:32 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Paul Volberding from the University of California San Francisco about long COVID and new long COVID disability guidelines. They discuss the symptoms and causes of long COVID and where to find treatment. Dr Volberding discussed his work with the National Academy of Medicine, which recently released a report on long COVID disability guidelines. 0:00 – Introduction 1:53 – What is long COVID? How does someone know if they have it? 6:22 – Risk factors and causes of long COVID 11:51 – Treatments for and research on long COVID 14:14 – When is long COVID a disability? Disability recommendations from the National Academy of Medicine on long COVID 19:53 – How does someone with long COVID get help? 23:54 - Closing Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 22 – Update on Emerging Infections – COVID-19, Measles, and More - with Dr Peter Chin-Hong | 30 Jul 2024 | 00:26:03 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Peter Chin-Hong from the University of California San Francisco to get an update on important emerging infections. They discuss the current outbreak of COVID-19 and trends in the epidemiology of the disease. They also address emerging measles cases and the underlying pathophysiology of the disease. They also discuss the impact of vaccine disinformation on the risk of measles transmissibility. Finally, they address emerging infections such as avian flu, vaccine developments, and address others like respiratory syncytial virus (RSV) and pertussis. 0:00 – Introduction 1:42 – Status of the current COVID-19 outbreak 3:48 – Update on treatments and vaccination for COVID-19 11:53 – Overview of measles and transmissibility 15:30 – Measles herd immunity and vaccine disinformation 19:50 – Other emerging infections and vaccine developments 23:21 – Closing thoughts __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 21 - New HIV Prevention: “What I’m Excited About” with Dr Raphael Landovitz | 16 Jul 2024 | 00:32:40 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Raphael Landovitz from the UCLA Medical School about the latest information on HIV prevention via Preexposure Prophylaxis, or PrEP. They discuss the history of PrEP and early efficacy and then move into a discussion of the evolution of PrEP from episodic dosing to longer-acting therapies. The episode also highlights recent research and how that may impact the future of PrEP dosing. 0:00 - Introduction 1:59 - History of Preexposure Prophylaxis, or PrEP 5:39 - Why initial PrEP regimens were not 100% effective 12:01 - Discussion of episodic PrEP and 2-1-1 regimens 16:22 - How longer-acting therapy has been shown to be superior to episodic dosing 20:29 - LEVI syndrome - what is it? 25:05 - What the future holds for PrEP 29:18 - Closing Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 20 - The Impact of GLP-1 Receptor Agonists with Dr Suman Srinivasa | 02 Jul 2024 | 00:26:59 | |
Episode 20 - The Impact of GLP-1 Receptor Agonists with Dr Suman Srinivasa In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Suman Srinivasa from Harvard Medical School about the impact of GLP-1 receptor agonists on diabetes and obesity. They discuss the mechanisms, benefits, and current and potential applications, including their use by people with HIV. The episode also highlights future prospects and challenges, including access to medication. 00:00 Introduction 01:42 Understanding GLP-1 Receptor Agonists 03:19 Mechanisms and Benefits of GLP-1 Receptor Agonists 05:34 Clinical Applications and Insurance Challenges 09:56 GLP-1 Receptor Agonists in HIV Patients 15:50 Future Prospects and Broader Applications 23:37 Closing Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 19 - Latest Update on Urgent Viral Outbreaks Recorded June 11, 2024 | 18 Jun 2024 | 00:59:28 | |
This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," which is a panel discussion held on June 11, 2024. Dr Paul A. Volberding from the University of California San Francisco serves as moderator and welcomes three distinguished panelists: Dr Carlos del Rio from Emory University, Yvonne Maldonado from Stanford University, and Dr Peter Chin-Hong from the University of California San Francisco. The episode covers various pressing topics, including updates on COVID-19, avian flu, MPOX, measles, and other viral diseases. Discussions touch on vaccines, their effectiveness, public health approaches, and current research. 00:00 Introduction to Going Antiviral Podcast 01:21 COVID-19 Current Issues and Personal Experiences 06:11 Long COVID and Paxlovid Study 07:59 Global Perspective on COVID-19 13:59 COVID-19 Vaccination Updates 23:52 Avian Flu: Current Concerns and Insights 29:15 The Threat of Avian Flu 29:46 Understanding H5N2 and Its Impact 33:09 The Ongoing MPOX Outbreak 37:02 Global Public Health Challenges 49:51 Travel Vaccines and Precautions 56:31 The Importance of RSV Vaccination 58:14 Concluding Remarks and Resources __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 18 - CROI 2024 Insights: Future Prospects of HIV Management and Cardiovascular Health with Dr Todd Brown | 04 Jun 2024 | 00:31:04 | |
Episode 18 - CROI 2024 Insights: Future Prospects of HIV Management and Cardiovascular Health with Dr Todd Brown Recorded May 3, 2024 This episode discusses the evolving landscape of HIV-related metabolic complications and cardiovascular health. Dr Michael Saag and Dr Todd Brown cover insights from CROI 2024, key studies on blood pressure management, the cardiovascular benefits of statins, and the promising role of GLP-1 receptor agonists in treating diabetes, obesity, and cardiovascular disease in people with HIV. 00:00 Introduction 01:56 Blood Pressure Management in HIV 09:56 The Impact of Statins on Cardiovascular Health 18:07 The Revolutionary Role of GLP-1 Receptor Agonists in HIV Management 27:01 Looking Ahead: The Future of HIV Treatment and Management 29:21 Closing Remarks and Future Directions __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 17 - CROI 2024 Insights: Progress and Challenges in HIV Antiretroviral Therapy with Dr Barbara Taylor Recorded May 2, 2024 | 21 May 2024 | 00:27:03 | |
Episode 17 - CROI 2024 Insights: Progress and Challenges in HIV Antiretroviral Therapy with Dr Barbara Taylor Recorded May 2, 2024
This episode of Going anti-Viral with Dr Michael Saag hosts Dr Barbara Taylor. They discussed topics covered at CROI 2024, including the 95-95-95 goal, long-acting antiretroviral therapies, mental health challenges in HIV care, and the potential for long-acting treatments in other viral diseases like hepatitis C.
00:00 Introduction and Remembering Dr Scott M. Hammer
00:27 CROI 2024 Highlights
02:55 Exploring the 95-95-95 Goal and Challenges in HIV Epidemic Control
09:01 Innovations in Long-Acting Antiretroviral Therapies
14:11 Advancements in Hepatitis C and B Therapies
16:51 COVID-19 Treatments and Resistance Concerns
19:26 Addressing Mental Health in HIV Care __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 34 – How far we’ve come with HIV – J. Kevin Carmichael | 31 Dec 2024 | 00:35:34 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Kevin Carmichael of the Arizona Department of Health Services about the unique challenges caregivers faced in addressing the HIV/AIDS pandemic. Dr Carmichael is a family physician who began work in HIV in 1983 while in medical school in Miami, Florida. During his residency at the University of Miami, Dr Carmichael co-authored one of the first written guidance for clinical HIV care “HIV/AIDS: A Primary Care Handbook.” Dr Saag and Dr Carmichael discuss their shared history in caring for people during the early years of HIV and AIDS in the 1980s and 1990s. They also discuss the challenges in managing families of people with AIDS. Dr Carmichael then reflects upon the transition in the care of HIV in 1995 when protease inhibitors became available, effectively the start of turning HIV into a manageable chronic disease. Finally, Dr Saag and Dr Carmichael provide thoughts for younger practitioners currently involved in HIV management. 0:00 – Introduction 1:22 – A discussion of the early years of HIV and AIDS care in the 1980s 7:43 – How Dr Carmichael came to focus on HIV and AIDS care 12:36 – Dr Carmichael’s transition to care in Arizona and differences from his time in Miami 16:08 –Discussion of advanced AIDS and working with families of people with HIV at the time 23:12 – The arrival of protease inhibitors in 1995 and the transition to management of a chronic disease 31:00 – Closing remarks and reflections for younger practitioners involved in HIV care __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 16 - Insights on HIV Cure by Stem Cell Transplant with Dr Ravindra Gupta Recorded Live at CROI 2024 on March 3, 2024 | 07 May 2024 | 00:20:40 | |
Episode 16 - Insights on HIV Cure by Stem Cell Transplant with Dr Ravindra Gupta Recorded Live at CROI 2024 on March 3, 2024
In this episode of Going anti-Viral, Dr Michael Saag hosts Dr Ravindra Gupta. Dr Gupta is the infectious diseases expert who led the team that treated Adam Castillejo, also known as ‘The London Patient,' the second person known to have been cured of HIV. The discussion, recorded on March 3, 2024, at the Conference on Retroviruses and Opportunistic Infections (CROI), focused on the intricate process of finding a suitable stem cell donor, the immunologic and virologic considerations around the transplant process, and the collaborative medical team effort involved.
00:00 Introduction
00:30 The London Patient
03:05 Finding the CCR5∆32 Stem Cell Match
04:21 Clinical Challenges on the Transplant Journey
06:58 Post-Transplant Monitoring and Milestones
15:53 Reflecting on the Journey
18:51 Closing Thoughts and Acknowledgments __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 15 - A Journey from HIV to Cure with Adam Castillejo, also known as The London Patient, Part 1 Recorded Live at CROI 2024 on March 3, 2024 | 23 Apr 2024 | 00:24:50 | |
In this episode of Going anti-Viral, host Dr Michael Saag interviews Adam Castillejo, known as the London patient, who is the second person to have been cured of HIV infection. The discussion, recorded on March 3, 2024, at The Conference on Retroviruses and Opportunistic Infections (CROI), touches on Adam's initial HIV diagnosis in London during the early 2000s, the societal stigma and personal impact of the diagnosis, and his dual battle with HIV and cancer. Adam shares the complex journey of his treatment, including the failure of initial interventions and the ultimate success of a bone marrow transplant from a donor with a CCR5 delta 32 mutation, leading to his cure of HIV and cancer. The conversation delves into the technical aspects of bone marrow transplant, the emotional and physical challenges Adam faced during recovery, and the continued stigma he experiences even post-cure. The episode reflects on the broader implications of Adam's story for HIV research and societal perceptions of the disease. 00:00 Introduction 01:10 Adam's Early Struggle with HIV Diagnosis 02:46 Confronting Stigma and Finding Support 05:26 The Battle Against Cancer and Mental Health Challenges 08:35 The Turning Point: Bone Marrow Transplant 15:14 The Journey of Recovery 17:29 Life After the Cure 22:37 Concluding Thoughts __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 14 - HIV Treatment with Long-Acting Injectables with Dr Aadia Rana Recorded Live at CROI 2024 on March 4, 2024 | 09 Apr 2024 | 00:26:39 | |
Episode 14 - HIV Treatment with Long-Acting Injectables with Dr Aadia Rana Recorded Live at CROI 2024 on March 4, 2024 In this episode, Dr Michael Saag and Dr Adia Rana discuss a breakthrough study on using a long-acting injectable HIV treatment with conditional economic incentives for individuals who were unable to take oral therapy. Presented at CROI 2024, the study's positive outcomes offer an effective option for certain individuals with no other options for continuing oral antiretroviral therapy. Updated Treatment Recommendation on Use of Cabotegravir and Rilpivirine for People With HIV From the IAS-USA Guidelines Panel
00:00 Introduction to the Podcast and Guest
00:50 Exploring Adherence Challenges and Study Insights
03:27 The Evolution of HIV Treatment: From Oral to Injectable Therapies
10:59 Study Results: A New Alternative for Select Individuals with Limited Treatment Options
16:05 Navigating Real-World Applications and Ethical Considerations
21:08 Reflecting on the Journey and Looking Ahead
25:21 Closing Thoughts and Future Directions __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 13 - Advancements in STI Prevention: Insights from Dr Jean-Michel Molina Recorded at CROI 2024 on March 3, 2024 | 26 Mar 2024 | 00:28:31 | |
Episode 13 - Advancements in STI Prevention: Insights from Dr Jean-Michel Molina Recorded Live at CROI 2024 on March 3, 2024 In this episode of Going anti-Viral, Dr Michael Saag and Dr Jean-Michel Molina discuss recent developments in STI prevention, focusing on doxycycline as post-exposure prophylaxis (DoxyPEP) and the evaluation of a meningococcal vaccine for gonorrhea prevention in the ANRS Doxyvac trial. Recorded at CROI 2024, Dr Molina shares insights from clinical trials, including challenges with data analysis and implications for future STI prevention and vaccine research. 00:00 Introduction to the Podcast and Guest
00:30 Innovative Approaches in Clinical Care with Dr Jean-Michel Molina 00:54 Exploring the Impact of Doxycycline and Vaccines on STIs 01:50 Challenges and Insights from Clinical Trials 04:29 The Journey from Interim Analysis to Final Results 09:27 Addressing Data Discrepancies 21:05 Future Directions in STI Prevention and Vaccine Research 26:46 Closing Thoughts and the Importance of Trustworthy Research __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 12 - New Study on Treatments for Non-Alcoholic Fatty Liver Disease in People With HIV With Dr Jordan Lake Recorded Live from CROI 2024 | 12 Mar 2024 | 00:24:13 | |
Episode 12 - New Study on Treatments for Non-Alcoholic Fatty Liver Disease in People With HIV With Dr Jordan Lake Recorded Live from CROI 2024 In this episode, Dr Michael Saag speaks with Dr Jordan Lake live from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI). They discuss the prevalence of non-alcoholic fatty liver disease (NAFLD) among people with HIV and explore the effectiveness of the GLP-1 receptor agonist semaglutide, commonly used to treat diabetes and aid in weight loss, to treat NAFLD. Future areas of research are considered, including maintenance strategies post-weight loss and a placebo-controlled version of the study. 00:02 Introduction and Welcome 00:44 Discussion on Non-Alcoholic Fatty Liver Disease in People With HIV 01:56 Role of HIV in Non-Alcoholic Fatty Liver Disease 02:43 Understanding the Inflammation and Fat Accumulation in the Liver 04:38 Exploring the Impact of Nucleoside Therapy on Non-Alcoholic Fatty Liver Disease 06:37 Potential Treatments for Non-Alcoholic Fatty Liver Disease 07:35 The Role of Semaglutide in Treating Non-Alcoholic Fatty Liver Disease 13:36 The Importance of Routine Assessment for Non-Alcoholic Fatty Liver Disease 15:37 Exploring New Drugs for Treating Non-Alcoholic Fatty Liver Disease 18:49 The Challenges and Future Directions in Non-Alcoholic Fatty Liver Disease Research 22:25 Conclusion and Closing Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 11- Innovations in Vaccine Research: Single Cell Immunity Development With Dr Fabian Otte Recorded Live from CROI 2024 | 07 Mar 2024 | 00:23:40 | |
Episode 11 - Innovations in Vaccine Research: Single Cell Immunity Development With Dr Fabian Otte Recorded Live from CROI 2024 In this podcast episode, Dr Michael Saag converses with Dr Fabian Otte, a molecular biologist at the University of Basel in Switzerland, live from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI). Dr Otte shares insights into the ongoing development of an innovative SARS-CoV-2 vaccine that employs a single-cell immunity development approach. Highlighting its potential benefits, such as broader and longer-lasting immunity compared with mRNA vaccines. This pioneering vaccine research might also extend to other RNA viruses in the future.
00:02 Introduction to the Podcast and Guest
00:28 Discussion on the Development of Next-Generation SARS-CoV-2 Vaccines
00:50 Exploring a Single-Cell Immunity Approach
01:10 Understanding the Vaccine Development Process
02:42 The Potential of the New Vaccine
03:13 Challenges and Advantages of the New Vaccine
05:07 The Impact of the Vaccine on Immune Response __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 10 - Harnessing the Power of Bacteriophages With Dr Robert Schooley Recorded February 8, 2024 | 27 Feb 2024 | 00:32:30 | |
Episode 10 - Harnessing the Power of Bacteriophages With Dr Robert Schooley In this podcast episode, host Dr Michael Saag speaks with Dr Robert “Chip” Schooley, a distinguished Professor of Medicine in the Division of Infectious Diseases and Global Public Health at the University of California San Diego. They discuss the revolutionary potential of bacteriophages, viruses that can infect and kill bacteria. They detail the research efforts and case studies involved in understanding the potential deployment of bacteriophages as a medical treatment. The discussion also highlights the necessity for clinical trials and future research involving genetically engineered phages. 00:02 Introduction and Guest Profile 01:51 The Growing Problem of Antimicrobial Resistance 02:55 Understanding Bacteriophages 04:21 The History and Use of Bacteriophages in Labs 05:45 The Role of Bacteriophages in Molecular Biology 11:43 The Journey of Treating a Patient with Bacteriophages 19:19 The Future of Bacteriophage Therapy 31:05 Closing Remarks and Podcast Outro __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 9 - Understanding The Implementation of Doxycycline Post-Exposure Prophylaxis (DoxyPEP) and Addressing Sexually Transmitted Infections with Dr Annie Luetkemeyer Recorded January 30, 2024 | 13 Feb 2024 | 00:29:48 | |
Episode 9 - Understanding The Implementation of Doxycycline Post-Exposure Prophylaxis (DoxyPEP) and Addressing Sexually Transmitted Infections with Dr Annie Luetkemeyer
In this episode of Going anti-Viral, Dr Michael Saag has an insightful discussion with Dr Annie Luetkemeyer, a professor of medicine in the Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General at the University of California San Francisco. Centering around the state of sexually transmitted infections in the United States, rising cases, strategies for control, and the promising role of doxycycline post-exposure prophylaxis (DoxyPEP) 00:02 Introduction to the Podcast 01:31 Discussion on the State of Sexually Transmitted Infections 05:21 Exploring the Concept of Post-Exposure Prophylaxis 07:19 Understanding the Implementation of DoxyPEP 10:23 Effectiveness of DoxyPEP 17:41 Potential Side Effects and Concerns of DoxyPEP 22:37 Future Prospects of DoxyPEP in STI Prevention 28:04 Conclusion and Final Thoughts 28:46 Podcast Closing Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 8 - An Overview of The HIV/AIDS Epidemic, Prevention and Intervention Methods, and Future Strategies with Dr Susan Buchbinder Recorded January 16, 2024 | 30 Jan 2024 | 00:28:08 | |
Episode 8 - An Overview of The HIV/AIDS Epidemic, Prevention and Intervention Methods, and Future Strategies with Dr Susan Buchbinder In this episode of the Going anti-Viral podcast, host Dr Michael Saag speaks with Dr Susan Buchbinder, a professor of medicine, epidemiology, and biostatistics at the University of California, San Francisco. They discuss the HIV/AIDS epidemic, tracing its history from its rise in the early 80s to its current status. The conversation covers the efficacy of different preventive and treatment strategies, such as community engagement, behavioral changes, condom use, pre-exposure prophylaxis (PrEP), and the prospects of a future HIV vaccine. 00:02 Introduction to the Podcast 00:31 Guest Introduction: Dr Susan Buchbinder 01:10 History of the HIV Epidemic 05:01 The Role of Community in HIV Prevention 06:30 Prevention and Interventions 07:40 The Importance of HIV Testing 10:28 The Revolution of PrEP in HIV Prevention 12:42 The Challenges in Ending the HIV Epidemic 22:18 The Future of HIV Prevention 24:55 Conclusion and Final Thoughts __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 7 - A Conversation With Dr Katelyn K. Jetelina About Her Journey in The Field of Epidemiology, The Initial Handling of The COVID-19 Pandemic, The Spreading of Misinformation, And The Urgent Need to Rebuild Public Trust in Health Infrastructure | 16 Jan 2024 | 00:27:38 | |
Episode 7 - A Conversation With Dr Katelyn K. Jetelina About Her Journey in The Field of Epidemiology, The Initial Handling of The COVID-19 Pandemic, The Spreading of Misinformation, And The Urgent Need to Rebuild Public Trust in Health Infrastructure Recorded January 8, 2024. In this episode of Going anti-Viral, Dr Michael Saag speaks to epidemiologist Dr Katelyn K. Jetelina, co-founder of The Health Trust Initiative, and Senior Scientific Advisor to several government and non-profit agencies, including the White House, Centers for Disease Control and Prevention, and Resolve to Save Lives. The conversation, dated January 8, 2024, revolves around Dr Jetelina’s journey in the field of epidemiology, the initial handling of the COVID-19 pandemic, the spreading of misinformation, and the urgent need to rebuild public trust in health infrastructure. They also touch on the role of Artificial Intelligence (AI) in rapidly spreading misinformation for profit, and its potential to disseminate correct information. Dr Jetelina suggests that empowering community leaders with accurate scientific information and leveraging technologic innovations can play a key role in improving the public health system. 00:02 Introduction and Guest Presentation 01:09 Dr Jetelina's Journey Into Epidemiology 03:19 Understanding the Transmission of COVID-19 06:39 The Impact of COVID-19 and the Role of Public Health Officials 11:00 The Challenge of Misinformation and Disinformation 21:49 Addressing the Future: Preparing for the Next Pandemic 26:10 Conclusion and Final Remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 33 - Overview of Travel Medicine: Vaccines, Outbreaks, and More - Dr David Freedman | 17 Dec 2024 | 00:34:17 | |
Episode 33 - Overview of Travel Medicine: Vaccines, Outbreaks, and More - Dr David Freedman In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr David Freedman of the University of Alabama at Birmingham to provide an overview of travel medicine: vaccines, outbreaks, and more. Dr Freedman is a professor of infectious diseases and his research is focused on clinical tropical medicine, including the development of surveillance networks to characterize infectious disease morbidity in travelers and migrants. Dr Saag and Dr Freedman provide an overview of worldwide outbreaks such as: mpox, H5N1, Marburg virus, Ebola, dengue fever, chikungunya, and Zika virus. Dr Freedman discusses the treatments and vaccines available for each of these outbreaks. They also address the clinical challenges of treating individuals with emerging infections of unknown origin. Finally, Dr Saag and Dr Freedman address the acute setting of treating rabies exposures from bats and other wild animals. 0:00 – Introduction 1:11 – Overview of surveillance networks and current areas of concern 4:01– Discussion of mpox outbreaks including a new clade in the Democratic Republic of the Congo 7:10 – Risk of H5N1 human transmission 10:07 – Update on Marburg virus disease 12:22 – Current status of Ebola disease and availability of monoclonal antibodies for treatment 15:53 – Overview of outbreaks in the Caribbean: dengue fever and chikungunya 25:08 – Update on Zika virus 26:36 – Discussion of how to clinically address cases of emerging viruses like Oropouche virus 29:50 – How to prevent and treat rabies exposures from bats and other animals __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 6 - A Conversation With Dr Anthony Fauci on His Career and His Role in The Responses to AIDS and COVID-19. Recorded December 14, 2023 | 19 Dec 2023 | 00:32:07 | |
Episode 6 - A Conversation With Dr Anthony Fauci on His Career And His Role in the Responses to AIDS and COVID-19. Recorded December 14, 2023
Dr Michael Saag hosts Dr Anthony Fauci on this episode of the Going anti-Viral podcast, discussing Dr Fauci's career journey, his involvement in AIDS research, and his contribution towards managing other viral diseases. The conversation particularly focuses on the initial response to AIDS, the response to the COVID-19 pandemic, the vaccine development process, and the challenges and successes encountered. The podcast also highlights the significant shift in activism around public health crises, contrasting the constructive role of AIDS activists with the destructive anti-science activism faced during COVID-19.
00:02 Introduction and Background 00:42 Dr Anthony Fauci's Early Life and Career 02:07 Beginning of the AIDS Story 02:12 First Encounter with AIDS and Initial Response 03:34 The Turning Point in AIDS Research 04:16 Building the AIDS Research Team 12:04 The Role of Activism in AIDS Research 17:06 The Emergence of COVID-19 17:55 The Development of the COVID-19 Vaccine 25:58 The Challenges of Anti-Science Activism in the COVID-19 Era 29:29 The Future of Public Health Communication 30:28 Conclusion and Reflections __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 5 - An In-depth Discussion on Syphilis With Dr Meredith Clement, Associate Professor at Louisiana State University Health Sciences Center. Recorded at The 2023 RWHAP CLINICAL CONFERENCE in Portland, OR, Dec 4, 2023 | 12 Dec 2023 | 00:26:05 | |
Episode 5 - An In-depth Discussion on Syphilis With Dr Meredith Clement, Associate Professor at Louisiana State University Health Sciences Center. This special episode was recorded live from the 2023 Ryan White HIV/AIDS Program CLINICAL CONFERENCE in Portland, OR, on December 4th, 2023. __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 4 - A Deep Dive Into Vaccine Development with Dr Richard Koup, Deputy Director Chief, Immunology Laboratory Vaccine Research Center, NIAID, NIH. Recorded Live From The 2023 RWHAP CLINICAL CONFERENCE in Portland, OR, December 2, 2023 | 06 Dec 2023 | 00:29:30 | |
Episode 4 - A Deep Dive Into Vaccine Development With Dr Richard Koup, Deputy Director Chief, Immunology Laboratory Vaccine Research Center, NIAID, NIH. This special episode was recorded live from the 2023 Ryan White CLINICAL CONFERENCE in Portland, OR, December 2nd, 2023 __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 3 - Latest Update on Emerging And Reemerging Urgent Viral Outbreaks, Including COVID-19, MPOX, And Flu. October 2023 | 10 Nov 2023 | 00:57:12 | |
Episode 3 - Latest Update on Emerging And Reemerging Urgent Viral Outbreaks, Including COVID-19, MPOX, And Flu. October 2023
She joined moderator Paul Volberding, MD, and discussants Peter Chin-Hong, MD, and Carlos del Rio, MD, for a lively discussion on the latest hot-button issues in the field of infectious diseases. Key conversations focus on the state of the COVID-19 pandemic, the role of vaccines and the growing issues related to insufficient data when tracking and treating viral infections. The discussion further extends to examine the political backlash that threatens institutional trust, pushing for a stronger approach that involves community-based contributions to conquering infectious diseases. 00:08 Introduction and Guest Presentation 01:16 Guest Introductions and Backgrounds 04:48 Discussion on Current Infectious Disease Trends 09:14 The Role of Data in Tracking Disease Trends 12:30 The Politics of Public Health Data 16:41 The Impact of Politics on Vaccination 16:54 Vaccination Discussion: COVID-19, Influenza, and RSV 26:20 Influenza Season Discussion 28:24 Discussion on Vaccination Coverage and Data Collection 30:30 The Importance of Vaccination Timing and Convenience 31:33 Understanding RSV in Adults and Its Diagnosis 32:28 The Importance of Testing and the Impact of COVID-19 on Testing Practices 33:13 The Challenge of Distinguishing Between Different Respiratory Infections 34:27 Discussion on Influenza Vaccines and Their Effectiveness 36:08 The Importance of Vaccination and Addressing Vaccine Hesitancy 43:55 The Future of Vaccines 09:10 Addressing the Challenges of Misinformation and Trust in Public Health __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 2 - Latest Update on Urgent Virus Outbreaks, August 2023 Dialogue on Urgent Viral Diseases | 10 Nov 2023 | 00:55:29 | |
Episode 2 - Latest Update on Urgent Virus Outbreaks, August 2023 Dialogue on Urgent Viral Diseases This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Virus Outbreaks," which is a panel discussion held on August 1, 2023. Dr Paul A. Volberding from the University of California San Francisco serves as the moderator and welcomes three distinguished panelists: Dr Carlos del Rio from Emory University, Yvonne Maldonado from Stanford University and Dr Michael Saag from the University of Alabama Birmingham. discuss recent developments in COVID-19, MPOX, RSV, and HIV. This includes the the paradigm-shifting results of the REPRIEVE study, current hurdles in COVID-19 vaccination and antiviral treatment, and trends in RSV and MPOX. They also discuss the overall impact of COVID-19 on education and child development.
28:18 The Need for Open Discussions on COVID-19 Vaccines __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 1 - 40 Years Later: Looking Back at The Beginning of The HIV/AIDS Epidemic | 10 Nov 2023 | 01:23:54 | |
Episode 1 - 40 Years Later: Looking Back at the Beginning of the HIV/AIDS Epidemic In this episode of Going anti-Viral, we revisit a panel discussion titled "40 Years Later: Looking Back at the Beginning of the HIV/AIDS Epidemic," sponsored by the IAS–USA.
00:00 Introduction and Overview of the Podcast 00:37 Panel Discussion: Reflecting on the Early Days of the HIV Epidemic 01:20 Panelists Share Their Personal Experiences and Challenges 02:29 The Impact of HIV on Medical Professionals and Their Careers 03:01 The Spread of HIV in Different New York City Boroughs 03:45 Panelists' Current Roles and Their Initial Encounters with HIV 06:01 The Struggle with Internalized Homophobia in HIV Patients 06:26 The Evolution of HIV Treatment and the Reaction of Medical Providers 07:44 The Emotional Impact of the HIV Epidemic 20:06 The Challenges of Creating a System of Care for HIV Patients 21:23 The Stigma and Misunderstandings Surrounding HIV 40:29 The Role of Activism in the Fight Against HIV 41:35 Institutional Responses to the HIV Epidemic 43:21 Challenges in Pediatric Care for HIV Patients 44:10 Stigma and Discrimination in Healthcare 44:47 International Efforts in HIV Testing 47:01 Safety Measures in HIV Research Labs 48:43 Health and Hospitals Corporation's Role in HIV Care 50:01 The Impact of HIV on Medical Education and Training 54:11 The Role of Activism in the HIV/AIDS Response 55:40 Lessons from HIV for Future Pandemics 57:16 The Response of the Medical Community to HIV 58:21 The Importance of Addressing Social Determinants of Health 01:00:08 The Future of HIV Research and Care 01:06:34 Closing Remarks and Reflections __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Going anti-Viral Trailer | 30 Sep 2023 | 00:01:26 | |
Introducing Going anti-Viral, the podcast of the IAS–USA, a professional continuing medical education organization focused on HIV and other viral diseases. I’m Dr Michael Saag, professor emeritus of medicine and infectious diseases at the University of Alabama at Birmingham and volunteer member of the IAS–USA Board of Directors. __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 32 - Update on the New Antiretroviral Therapy Guidelines - Dr Rajesh Gandhi | 01 Dec 2024 | 00:36:25 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Rajesh Gandhi of Harvard Medical School and Massachusetts General Hospital about the new IAS-USA recommendations for HIV treatment and prevention. Dr Gandhi is the Chair of the guidelines panel, which published its recommendations in the Journal of the American Medical Association on December 1, 2024. Dr Gandhi and Dr Saag discuss the process by which the updated guidelines were created and provide an update on what’s new in the current edition. They address other important topics like how to treat patients with opportunistic infections, guidance on when to change therapy, and strategies for preventing HIV acquisition. Finally, Dr Gandhi makes recommendations for those using the guidelines, especially those using them for the first time. 0:00 – Introduction 1:19 – Overview of the guidelines’ creation process 3:52– New recommendations on when to start antiretroviral therapy 6:37 – New guidance on what regimens to start 9:34 – Discussion of other agents like bictegravir and dolutegravir in pregnancy 10:45 – How to treat patients with an opportunistic infection 14:09 – Concern about immune reconstitution inflammatory syndrome (IRIS) 16:33 – Guidance on when to change therapy and providing support 21:18 – How do the guidelines help people stay healthy – management of cancer, cardiovascular risk, and weight gain 24:41 – Discussion on prevention of HIV and sexually transmitted diseases 30:19 – What could not be addressed in the guidelines 33:17 – Final comments and how to use the guidelines Resources: https://jamanetwork.com/ __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 31 - Will we ever have a cure for Hepatitis B? - Dr Kenneth Sherman | 19 Nov 2024 | 00:31:25 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Kenneth Sherman of Massachusetts General Hospital and Harvard Medical School about the possibility of a cure for hepatitis B. The World Health Organization estimates that 254 million people were living with chronic hepatitis B globally in 2022. Dr Saag and Dr Sherman discuss the lifecycle of hepatitis B including the role that covalently closed circular DNA (cccDNA) plays in the hepatitis B virus (HBV) replication cycle. Dr Sherman defines functional cure and provides an overview of the most promising cure strategies. They also discuss whether antiretroviral drugs like tenofovir, used in the treatment of HIV, can contribute toward a functional cure of hepatitis B. Dr Sherman discusses other strategies like capsid assembly modulators (CAMs), monoclonal antibodies, and toll-like receptor (TLR) agonists. Finally, they discuss the effectiveness of the hepatitis B vaccine in prevention and look forward to the future by considering a timeline for a cure based on the status of ongoing clinical trials. 0:00 – Introduction 1:23 – Overview of the lifecycle of hepatitis B 5:29 – Discussion of the most promising cure strategies 7:11 – Defining functional cure 10:56 – The role of drugs like tenofovir in a functional cure 13:39 – Targets that can affect viral production 16:04 – Potential of capsid assembly modulators (CAMs) 18:03 – Other strategies like immune modulators and monoclonal antibodies 22:29 – Interest in toll-like receptor (TLR) agonists and therapeutic vaccines 24:32 – Outlook for the future and the effectiveness of a hepatitis B vaccine in prevention __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 30 - Update on Mpox - a Public Health Emergency - Dr Jason Zucker | 05 Nov 2024 | 00:23:31 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Jason Zucker of Columbia University and the New York City STD Prevention Training Center about mpox and the mpox outbreak. Dr Saag and Dr Zucker discuss the 2 clades of mpox, how it is transmitted, and which clade is associated with the most recent mpox outbreak. They also discuss how to test for mpox and how people with HIV present with mpox based on their HIV viral load. Dr Zucker gives a detailed update on the STOMP (Study of Tecovirimat for Human Mpox Virus) trial that evaluates the efficacy of the antiviral tecovirimat, also known as TPOXX, for the treatment of mpox. They also address the role of vaccination in mpox, its uptake and efficacy. Finally, Dr Zucker offers his perspective on how practitioners and public health officials can address ongoing mpox outbreaks in the US and globally, including a second public health emergency of international concern that was declared in the Democratic Republic of the Congo and surrounding countries in August by the World Health Organization (WHO). 0:00 – Introduction 1:25 – Description of mpox and its 2 clades 2:07 – Overview of the current mpox outbreak 3:11 – Mpox transmission 4:29 – Mpox in people with HIV 6:35 – Testing for mpox 9:05 – The STOMP study, enrollment, and effectiveness of tecovirimat 15:58 – The role for vaccination for mpox and who should receive it 20:38 – Outlook for the future __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 29 - Comparing and Contrasting Health Care Policies from different sides of the Aisle - Dr Jennifer Kates | 22 Oct 2024 | 00:28:53 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Jennifer Kates of KFF to compare and contrast health care policies from different sides of the aisle. Dr Kates provides an update on the Patient Protection and Affordable Care Act (ACA) and efforts to repeal the healthcare program in the United States. Dr Saag and Dr Kates also discuss the status of Medicaid expansion in the US and the impact of access to care in states where Medicaid has been expanded. They also discuss the impact of the Ryan White HIV/AIDS Program on healthcare for people with HIV and the long-term outlook for funding for the program. In addition, there is a detailed overview and outlook of funding for the 340B Drug Pricing Program that allows eligible hospitals and other healthcare organizations to purchase outpatient drugs at a discount from pharmaceutical manufacturers. Finally, Dr Saag and Dr Kates discuss the erosion of trust in science and public health officials in the US and reasons to be optimistic for the future. 0:00 – Introduction 1:15 – Update on the ACA 3:19 – Discussion of efforts to repeal the ACA 5:32 – Status of Medicaid expansion in the US 8:56 – Overview of access to HIV care through Ryan White 10:37 – Access to health insurance coverage through Ryan White 12:31 – What is 340B funding? 15:45 – Possible pressures on 340B funding 17:45 – Outlook for Ryan White funding and availability of PrEP in the program 21:34 – Discussion of the erosion of trust in science and public health 26:42 – Outlook for the future __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 28: Special Episode - Latest Update on Urgent Virus Outbreaks: October 2024 | 15 Oct 2024 | 01:02:12 | |
This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," a panel discussion held on October 4, 2024. Dr Carlos del Rio from Emory University serves as moderator and welcomes 3 distinguished panelists: Dr Yvonne Maldonado from Stanford University, Dr Peter Chin-Hong from the University of California San Francisco, and Dr Paul Sax from Brigham and Women’s Hospital. The episode covers various pressing topics, including updates on COVID-19, avian flu, mpox, and other viral diseases. Discussions touch on vaccines, their effectiveness, public health approaches, and current research. 0:00 – Introduction and overview of ongoing viral outbreaks 3:59 – Update on respiratory viruses and vaccination – seasonal flu, RSV, and COVID-19 12:17 – Discussion of monoclonal antibody treatment for COVID-19 14:15 – Update on the use of Paxlovid for COVID-19 18:48 – COVID-19 vaccination – protein vaccines vs. mRNA vaccines 22:48 – Update on pertussis 28:54 – Discussion of seasonal influenza and vaccination 32:55 – Effectiveness of shingles and RSV vaccines 35:57 – Discussion of vaccination during pregnancy 40:02 – Audience questions 43:04 – Update on H5N1 (avian flu) outbreak 52:00 – Update on Marburg virus outbreak in Rwanda 55:43 – Discussion of mpox outbreak in central Africa 59:29 – Concluding remarks __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||
| Episode 27 - What’s Hot from the Warm Line: Top 10 Questions from HIV Clinicians | 08 Oct 2024 | 00:32:22 | |
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Carolyn Chu and Dr Lealah Pollock from the University of California San Francisco about the National Clinician Consultation Center (NCCC). The NCCC offers guidance to health care practitioners on HIV, hepatitis, and substance use. Dr Chu and Dr Pollock discuss the most common questions asked by clinicians to the NCCC warm line such as: infant feeding by people with HIV, antiretroviral treatment (ART) for pregnant people with HIV, and the use of long-acting antiretroviral drugs. They also discuss how they respond to questions about the latest developments in preexposure prophylaxis (PrEP) care, care for people with sexually transmitted infections (STIs), and health care practitioner exposures. Finally, they share their thoughts about working for the NCCC and the service they offer to US-based clinicians. 1:31 – History and overview of the services provided by the NCCC 4:31 – A common question – infant feeding in people with HIV 10:03 – ART for pregnant people with HIV 13:53 – Questions about long-acting antiretroviral drugs 16:55 – Interpretation of resistance-associated mutations 18:30 – The NCCC warm line service model 20:34 – Questions about administering PrEP and impact of recent developments in PrEP research 26:08 – Questions about postexposure prophylaxis (PEP) for STIs 27:25 – Recommendations for health care practitioner exposures 29:17 – Final thoughts and closing remarks Resources: Contact the National Clinician Consultation Center (NCCC): __________________________________________________ Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. | |||