Going anti-Viral - Going Anti-Viral

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Must Listen Episode - Latest Update on Emerging Viral Infections and Current Public Health Threats

Season 1 · Episode 36

Saturday, January 18, 2025 • Duration 01:03:33

This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," a panel discussion held on January 15, 2025. This IAS-USA Dialogue is a must listen as our distinguished panel of infectious diseases experts dives deep into some of the most pressing public health challenges facing the world today. Moderated by Carlos del Rio, MD, a Distinguished Professor of Medicine in the Division of Infectious Diseases at Emory University School of Medicine, this Dialogue brings together world-class experts Yvonne Maldonado, MD, Peter Chin-Hong, MD, and Jason Zucker, MD, to discuss the latest news on urgent and emerging viral outbreaks, including mpox, avian flu (H5N1), respiratory syncytial virus (RSV), measles, human metapneumovirus, and COVID-19/long COVID.

The panel also reflects on the alarming erosion of public trust in public health experts, which has been compounded by misinformation and the long-term effects of the COVID-19 pandemic.

0:00 – Introduction

2:27 – Update on mpox including treatment options

11:09 – Discussion of avian flu (H5N1), influenza, and vaccination in human and animals

27:36 – Impact of avian flu (H5N1) on dairy and other agriculture industries and the role of public health in supporting the economy

32:47 – Impact of recent study on Tamiflu in treatment recommendations and discussion of Biloxivir

37:37 – Update on COVID-19 – vaccination, treatment with Paxlovid, other treatment options, and long COVID

48:27 – Recent updates on respiratory syncytial virus (RSV) and vaccination

52:03 – Discussion of human metapneumovirus

54:25 –Impact of misinformation on the reduction in measles vaccinations and the health risks of measles to the population at large

59:54 – Concluding remarks

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.

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Episode 35 - Reflections on the Role of HRSA in the Care of People with HIV – Laura Cheever

Season 1 · Episode 35

Tuesday, January 14, 2025 • Duration 32:48

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Laura Cheever who was, until recently, the Associate Administrator of the HIV/AIDS Bureau at the Health Resources and Services Administration (HRSA). She joined HRSA in 1999 when she served as the national director of the Ryan White AIDS Education and Training Center program. Dr Cheever is Board Certified in Infectious Diseases and continues to provide clinical care for patients with HIV. Dr Cheever describes her early work at HRSA and the Ryan White HIV/AIDS Program. Dr Cheever and Dr Saag then discuss quality measures adopted to demonstrate program effectiveness and the impact these efforts had on funding. They also discuss the staff in the program and their role in working with local providers. They address the role that private insurance, the Affordable Care Act, and different presidential administrations play in the services of the program as well as work left to be done and look ahead to the next ten years of HIV care.

0:00 – Introduction

1:40 – A discussion of Dr Cheever’s early years at the Health Resources and Services Administration (HRSA)

7:51 – Implementation of national quality measures for HIV care using data collection through CAREWare

11:41 – How did new information impact decision making regarding Ryan White funding decisions

15:04 – Impact of changing guidelines on direction given to the Ryan White clinics

19:26 – The staff at HRSA and the impact of potential budget cuts on the program

24:05 – The role private insurance and the Affordable Care Act had in providing treatment through the Ryan White program

25:10 – Do different presidential administrations influence the services of the Ryan White program

27:34 – Discussion of the work left to be done

29:29 – Predictions for the next ten years of HIV care and closing remarks

__________________________________________________Produced by IAS-USA, Going–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Episode 26 - The Exploding Epidemic of Substance Use Disorder: What Can We Do? - Dr Sandra Springer

Season 1 · Episode 26

Tuesday, September 24, 2024 • Duration 28:21

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Sandra Springer from the Yale School of Medicine about the substance use disorder epidemic. Dr Springer describes the history of the epidemic and the recent crisis of overdose deaths in the United States. She talks about the increase in overdose deaths since 1999 due to prescription opioids. Dr Saag and Dr Springer review how HIV practitioners can manage patients with substance abuse disorder, including a discussion of how to manage patients undergoing withdrawal. Finally, they address harm reduction strategies available to practitioners and new data showing a reduction in overdose deaths, providing long-term hope for the effectiveness of these strategies. But they note that more research, funding, and outreach is needed to meet the risks that opioid and non-opioid substances pose in the future.

0:00 – Introduction

1:22 – Magnitude of the substance use disorder epidemic

2:31 – Factors that led to the increase in deaths after 1999

3:54 – Background on widespread fentanyl use

5:22 – Impact of prescription opioids for chronic pain management on addictions

7:52 – HIV healthcare practitioners’ role in managing patients with substance use disorders

10:15 – Management of withdrawal, including long-term management options

18:33 – Harm reduction strategies and the use of naloxone to prevent overdose deaths

23:04 – Review of new data showing reduction in overdose deaths in the United States

24:19 – Closing remarks and expectations for the next 10 years

IAS–USA resources on substance use disorders:

-- MATE Act CME - https://www.iasusa.org/dea-compliant-cme-resource-center/

-- Fellow Resources:

Episode 25 - What’s all this fuss about Bird Flu (Influenza A) – with Dr Andrew Pavia

Season 1 · Episode 25

Tuesday, September 10, 2024 • Duration 34:56

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Andrew Pavia from the University of Utah about influenza A, specifically the H5N1 strain. Dr Pavia describes the progression of H5N1 and its recent impacts on poultry and other animal populations, including an overview of a recent outbreak among dairy cattle and whether there is a risk to humans exposed on farms and the milk supply at large. They discuss how influenza vaccines are determined each year and the timing of when best to recommend vaccination. They describe treatment options for influenza and their effectiveness against H5N1. Finally, they address public health measures taken during influenza outbreaks and the COVID-19 pandemic, offering lessons learned for future influenza outbreaks in humans.

0:00 – Introduction

1:32 – Overview of influenza

2:54 – Human susceptibility to influenza

5:20 –Types of influenza and evolution of H5N1 from birds to mammals

9:24 – Natural history of transmission in humans

12:34 – Current outbreak of H5N1 in dairy cattle and risk to the milk supply

16:48 – Overview of influenza vaccines and immunity

18:47 – Optimal time to get the influenza vaccine and combined vaccination for COVID-19

23:36 – Treatment options with onset of influenza symptoms and H5N1 is resistance

30:00 – Lessons learned from public health measures taken to protect against outbreaks of influenza and COVID-19

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

GoingViral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on:

Episode 24 - HPV and Anal Cancer: Vaccination and Screening in People with HIV - Dr Timothy Wilkin

Season 1 · Episode 24

Tuesday, August 27, 2024 • Duration 27:14

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Timothy Wilkin from the University of California San Diego about the human papillomavirus (HPV) and anal cancer with options for screening, prevention, and vaccination.

They provide an overview of HPV and the types of HPV that lead to cancer. They discuss screening and prevention for anal cancer at HIV and PrEP clinics. They also discuss the findings of the ANCHOR study that demonstrated that high-resolution anoscopy screening detects and prevents anal cancer caused by HPV. Finally, they review HPV vaccination, its effectiveness, and the challenges with uptake of the vaccine in the population at large.

0:00 – Introduction

1:32 – Overview of HPV

3:01 – HPV and cancer

4:43 – Screening and prevention for anal cancer at HIV and PrEP clinics

9:38 – Findings of the ANCHOR study – efficacy of high resolution anoscopy in detecting anal cancer caused by HPV.

11:32 – Barriers to screening and treatment

15:05 – HPV vaccination - recommendations and efficacy

18:10 – Challenges with HPV vaccination uptake

24:30 – Next ten years of HPV and closing remarks

Resources and articles:

Single dose HPV vaccine article
https://pubmed.ncbi.nlm.nih.gov/35693874/

ANCHOR trial
https://pubmed.ncbi.nlm.nih.gov/35704479/

CDC OI HPV guidelines
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/humanInternational Anal Neoplasia Society (guidelines and HRA training)

Episode 23 - New Long COVID Disability Guidelines - with Dr Paul Volberding

Season 1 · Episode 23

Tuesday, August 13, 2024 • Duration 26:32

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Paul Volberding from the University of California San Francisco about long COVID and new long COVID disability guidelines. They discuss the symptoms and causes of long COVID and where to find treatment. Dr Volberding discussed his work with the National Academy of Medicine, which recently released a report on long COVID disability guidelines.

0:00 – Introduction

1:53 – What is long COVID? How does someone know if they have it?

6:22 – Risk factors and causes of long COVID

11:51 – Treatments for and research on long COVID

14:14 – When is long COVID a disability? Disability recommendations from the National Academy of Medicine on long COVID

19:53 – How does someone with long COVID get help?

23:54 - Closing Remarks

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.

Follow Going anti-Viral on:

Episode 22 – Update on Emerging Infections – COVID-19, Measles, and More - with Dr Peter Chin-Hong

Season 1 · Episode 22

Tuesday, July 30, 2024 • Duration 26:03

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Peter Chin-Hong from the University of California San Francisco to get an update on important emerging infections. They discuss the current outbreak of COVID-19 and trends in the epidemiology of the disease. They also address emerging measles cases and the underlying pathophysiology of the disease. They also discuss the impact of vaccine disinformation on the risk of measles transmissibility. Finally, they address emerging infections such as avian flu, vaccine developments, and address others like respiratory syncytial virus (RSV) and pertussis.

0:00 – Introduction

1:42 – Status of the current COVID-19 outbreak

3:48 – Update on treatments and vaccination for COVID-19

11:53 – Overview of measles and transmissibility

15:30 – Measles herd immunity and vaccine disinformation

19:50 – Other emerging infections and vaccine developments

23:21 – Closing thoughts

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on:

Episode 21 - New HIV Prevention: “What I’m Excited About” with Dr Raphael Landovitz

Season 1 · Episode 21

Tuesday, July 16, 2024 • Duration 32:40

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Raphael Landovitz from the UCLA Medical School about the latest information on HIV prevention via Preexposure Prophylaxis, or PrEP. They discuss the history of PrEP and early efficacy and then move into a discussion of the evolution of PrEP from episodic dosing to longer-acting therapies. The episode also highlights recent research and how that may impact the future of PrEP dosing.

0:00 - Introduction

1:59 - History of Preexposure Prophylaxis, or PrEP

5:39 - Why initial PrEP regimens were not 100% effective

12:01 - Discussion of episodic PrEP and 2-1-1 regimens

16:22 - How longer-acting therapy has been shown to be superior to episodic dosing

20:29 - LEVI syndrome - what is it?

25:05 - What the future holds for PrEP

29:18 - Closing Remarks

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on:

Episode 20 - The Impact of GLP-1 Receptor Agonists with Dr Suman Srinivasa

Season 1 · Episode 20

Tuesday, July 2, 2024 • Duration 26:59

Episode 20 - The Impact of GLP-1 Receptor Agonists with Dr Suman Srinivasa

In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Suman Srinivasa from Harvard Medical School about the impact of GLP-1 receptor agonists on diabetes and obesity. They discuss the mechanisms, benefits, and current and potential applications, including their use by people with HIV. The episode also highlights future prospects and challenges, including access to medication.

00:00 Introduction

01:42 Understanding GLP-1 Receptor Agonists

03:19 Mechanisms and Benefits of GLP-1 Receptor Agonists

05:34 Clinical Applications and Insurance Challenges

09:56 GLP-1 Receptor Agonists in HIV Patients

15:50 Future Prospects and Broader Applications

23:37 Closing Remarks

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on:

Episode 19 - Latest Update on Urgent Viral Outbreaks Recorded June 11, 2024

Season 1 · Episode 19

Tuesday, June 18, 2024 • Duration 59:28

This episode of Going anti-Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," which is a panel discussion held on June 11, 2024.

Dr Paul A. Volberding from the University of California San Francisco serves as moderator and welcomes three distinguished panelists: Dr Carlos del Rio from Emory University, Yvonne Maldonado from Stanford University, and Dr Peter Chin-Hong from the University of California San Francisco. The episode covers various pressing topics, including updates on COVID-19, avian flu, MPOX, measles, and other viral diseases. Discussions touch on vaccines, their effectiveness, public health approaches, and current research.

00:00 Introduction to Going Antiviral Podcast

01:21 COVID-19 Current Issues and Personal Experiences

06:11 Long COVID and Paxlovid Study

07:59 Global Perspective on COVID-19

13:59 COVID-19 Vaccination Updates

23:52 Avian Flu: Current Concerns and Insights

29:15 The Threat of Avian Flu

29:46 Understanding H5N2 and Its Impact

33:09 The Ongoing MPOX Outbreak

37:02 Global Public Health Challenges

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