Microbiome Medics – Détails, épisodes et analyse

In this episode of Microbiome Medics, Dr. Siobhan McCormack is joined by Professor Egija Zaura from the Academic Centre of Dentistry in Amsterdam to explore the significance of the oral microbiome. They discuss why the oral microbiome warrants attention alongside the gut microbiome, emphasizing its role as the body’s first defense against pathogens.

The conversation highlights the complex interactions within the oral cavity and the consequences of dysbiosis on oral health, linking it to systemic issues like diabetes and cardiovascular diseases. As practical applications are discussed, Professor Zahra shares the importance of saliva, dietary choices, and the implications of oral hygiene products on microbial diversity. The hosts encourage proactive oral health practices, translating intricate research into actionable insights for listeners.

Professor Egija Zaura has a degree in dentistry. She is University Research Chair Professor in Oral Microbial Ecology at ACTA. Her research topics span from biofilm models and clinical studies to advanced molecular technologies in oral microbial diagnostics and complex sequencing data analyses. Her current principal interests lay on oral microbial ecology at health and disease, and translating this fundamental knowledge to the clinical practice.

This podcast is presented in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:

The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this episode of Microbiome Medics, host Sheena welcomes microbiome science celebrity Dr. Jack Gilbert about his journey from butterfly ecologist to a leading figure in microbiome research. They explore the American Gut Project's goal of understanding microbiome diversity, the Nutrition Precision Health Program’s focus on linking nutrition to health outcomes, and the clinical implications of microbiome data in patient care. Jack highlights the potential of pharmacomicrobiomics and discusses advancements in linking the microbiome to mental health. He also introduces his co-authored book, “Dirt is Good,” aimed at helping parents support their children's microbiomes. This conversation offers a compelling look at the future of microbiome science and its impact on health.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Don't miss the first of two episodes on the role of the microbiota-gut-brain axis (MGBA) in chronic pain.

30% of the UK population suffer from chronic pain and pharmacological options have proved disappointing and even downright dangerous . Could harnessing the gut microbiome be part of new approaches for this prevalent condition? Our tireless Microbiome Medics cover the MGBA basics, marvel at brain microglia and astrocytes, and identify chronic inflammation as a major player in chronic pain. They discuss a 2023 pilot study by Sala-Climent et al. looking at the effect of an anti-inflammatory diet on measures of chronic pain. 

Part two of this podcast will include UK Pain Specialist and author Dr Deepak Ravindran, who will be talking about his Lifestyle Medicine approach to chronic pain which includes optimising the gut microbiome and nutrition.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this episode we explore the fascinating vaginal microbiome. With the expertise of Professor Sarah LeBeer, a leading scientist in the field , we unravel  the complexities of this unique microbial ecosystem and its crucial role in women's health. Listen in as we discuss the dominance of lactobacilli in maintaining vaginal health and their potential influence  on other aspects of  health and well-being. Professor Lebeer explains the  dynamic shifts the vaginal microbiome undergoes across the lifespan, and the  implications these changes may have on both maternal and newborn health.

This  conversation celebrates citizen science through the Isala project. This initiative not only uncovered pivotal insights into vaginal microbiome variations but also empowered women to engage in open dialogues about their vaginal health. We address the impacts of personal habits on this intriguing microbial ecosystem  and how the knowledge gained may help shape diagnostics and treatments in women's health.

To wrap up, we explore the potential of probiotics tailored for the vaginal microbiome and the challenges they present. As we sift through the confusion surrounding probiotic products, we share practical advice for healthcare professionals and patients alike on nurturing a healthy vaginal ecosystem. From diet to lifestyle choices, we offer resources and insights that encourage proactive stewardship of one's microbiome. So, whether you're a healthcare professional or simply someone interested in the wonders of the human body, this episode is packed with intriguing discoveries and actionable knowledge.

To find out more about Professor Lebeer's work:
https://lebeerlab.com/
https://isala.be/

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Hello, fellow gut-health enthusiasts.

In this episode Dr. Siobhan McCormack and Dr. Sheena Fraser welcome you to a conversation about the popular fermented beverage that's sweeping the health world: kombucha. They explain what it is, how it’s made and what it might do for your gut health.

Learn about the celebrated SCOBY(symbiotic culture of bacteria& yeast) and how to brew your own kombucha before hearing from Emma & Kenny , founders of HIP POP beverages and fellow microbiome enthusiasts who tell us how they have turned a passion  for kombucha  into a thriving and rapidly expanding business.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

As 2023 draws to a close, it is time for Microbiome Medics to pause and reflect on
12 months of podcasts, conferences, talks, and courses. All with the aim of raising
awareness of the importance of the gut microbiome (and other human microbiomes) to all aspects of healthcare.

Thankfully, they are not just stuffing your stocking with knowledge, but also
adding some holiday cheer. Tune in for a festive exchange of microbiome-related
gifts and book recommendations. Perfect for the curious minds in your life.
Plus, find out what microbiome nerds gift each other for Christmas at the
Microbiome Medics ‘not so secret Santa’ office party.

A Christmas message from Microbiome Medics
Thank you to all the listeners for your support, constructive feedback, and great
ideas and most of all, thank you for listening! Thank you also for the incredible
feedback we have had for our Gut Microbiome for Clinicians course, which endeavours
to provide an in-depth understanding of the gut microbiome for fellow HealthCare
Professionals.

Remember to take care of your microbiomes over the festive season, and we look
forward to another year of exploring, learning, and improving our health through
understanding the fascinating world of microbiomes.

Book Recommendations:

• There's a Zoo in my Poo by Felice Jacka & Rob Craw
• Dark Matter by Dr James Kinross
• Animal Moves by Darryl Edwards
• The Plant-based Diet Revolution by Dr Alan Desmond

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

'When I found myself teetering on the edge of prediabetes, I knew I needed to make a change. I chose movement, and it changed my life.' - On our latest episode, we discuss this journey with Darryl Edwards, a movement coach and author, who made this transformation. From a fascinating conversation about the Primal Play Method to an enlightening discussion on the transformative power of exercise on the gut microbiome, this episode is full of insights and inspiration.

We also delve into fascinating research on the effects of exercise on our gut health. Darryl and I explore interesting animal studies that show how physical activity can boost the presence of beneficial bacteria and reduce the number of harmful ones. We discuss how diet and other factors associated with athleticism can enhance these benefits. We also touch on the importance of nutrition for athletes, especially in relation to energy expenditure, mitochondrial function, and the production of short-chain fatty acids.

Finally, we explore the implications of modern sedentary lifestyles on our health and gut microbiomes. From the evolution of furniture to the advancement of technology, we discuss how our environments encourage inactivity. But it's never too late to make a change. Whether it's introducing exercise early in life, opting for outdoor activities like gardening, or just learning to move more, every step towards a more active lifestyle can have profound impacts on our health and gut microbiomes. So, join us on this journey of discovery and learn how to reclaim the joy of movement!

https://www.primalplay.com/blog/unlock-the-power-of-play-how-active-play-boosts-adult-health-happiness

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this podcast episode, Dr Sheena Fraser and Dr Siobhan Mccormack (aka Microbiome Medics) discuss the significant impact of antibiotics on the gut microbiome. They are joined by an expert in this area Dr Anastasia Theodosiou, who is both a Microbiome Scientist and a  Registar in Microbiology & Infectious Disease.

Dr Anastasia introduces her novel term Microbiotoxicity which can be used to  explain and  predict the effects of antibiotics on human  microbiomes. The discussion also covers other drugs like proton pump inhibitors and selective serotonin reuptake inhibitors (SSRIs) which can also perturb the gut microbiome. Listeners will gain insights into the recovery timeline of the gut microbiome after antibiotic exposure and the implications of gut microbiome disruptors like Caesarian section delivery and neonatal formula feeding on both gut health and other health outcomes across the lifespan. This episode highlights the importance considering the impact of medications on the gut microbiome and how we might start to bridge the gap between microbiome research and clinical practice.

Dr Theodosiou is an MRC Clinical Research Training Fellow (University of Southampton) and an Infectious Diseases and Medical Microbiology Registrar. Her research involves the use of controlled human infection to study microbiome development in early life, including the world’s first respiratory human challenge study in pregnancy.

https://idiotspodcasting.buzzsprout.com/1782416/13193172-56-antibiotics-breastfeeding-and-infant-health

Theodosiou AA, Jones CE, Read RC, Bogaert D. Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome. Curr Opin Infect Dis. 2023;36(5):371-378. doi:10.1097/QCO.0000000000000945 https://www.hellomicro.org/post/microbiome-microbiotoxicity https://www.nbmedical.com/blog/microbiotoxicity

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:

The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this 3rd & final episode Dr Sheena & Dr Shiv get to chat to Professor Robert Thomas , a full time NHS Consultant Oncologist, Sorts and Nutrition scientist and active medical researcher who explains why he thinks the gut microbiome and gut health are key to cancer prevention, response cancer therapies and survivorship.

They discuss diet, research and patient empowerment. It seems that small, simple , achievable dietary and behaviour changes really can improve outcomes , overall wellbeing and survivorship. 

Professor Robert Thomas is a full time NHS Consultant Oncologist at Bedford and Addenbrooke's Hospitals, a teacher at Cambridge University and visiting Professor of Sports and nutritional science at the University of Bedfordshire. He trained at the Royal Marsden Hospital had period of full-time laboratory and clinical research at the Institute of Cancer and Duke University, North Carolina. He now manages patients with chemotherapy, radiotherapy, hormones and biological targeted treatments but incorporates nutritional and lifestyle strategies to enhance their effect, reduce side effects and improve overall wellbeing.

He is also head of a Lifestyle and Cancer Research Unit which designs and conducts government backed studies evaluating the impact of exercise, diet and natural therapies on cancer, other chronic diseases and more recently recovery from Covid-19. In collaboration with Universities in Southern California, Cambridge and Glasgow, this unit has published over 100 peer reviewed scientific papers and regularly presents studies across the World. He is a patron of two cancer support charities and advises Macmillan and other support groups on their informal materials for patients.

He previously led the UK Polybalm and Pomi-T randomised studies and currently leads the UK's covid-19 nutritional intervention study (The Phyto-V study) assessing whether prebiotic polyphenol rich foods plus a probiotic could lower the severity and duration of symptoms.

He is author of the UK bestseller "How to Live" and has been awarded The British Oncology Association “Oncologist of the Year” and The Royal College of Radiologist Research Medal.

Twitter: @cancernetUK

Facebook: @cancernetUK

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:

The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

In this 2nd episode on cancer and the gut microbiome , our Microbiome Medics duo continue their exploration of the impact of the gut microbiome on all aspects of cancer biology focusing on responses to cancer therapies and the potential effects of medications such as antibiotics and proton pump inhibitors on the resident microbes.

Dr Sheena discusses practical advice to improve gut health that she discusses with her NHS patients diagnosed with cancer and Dr Shiv introduces a few new concepts including the Oestrobolome and its importance to breast cancer and discusses a paper describing microbiomes within several different types of human cancers which may help further understanding of the impact of microorganisms on the hallmarks of cancer.

This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.

Disclaimer:
The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.