While the U.S. was busy capturing Venezuelan President Nicolas Maduro, someone online was  busy placing bets on prediction markets on the ouster. And these well-timed bets may have netted a still-anonymous someone more than $400,000. Was this a case of kind-of-legal insider trading? Or is America going all-out on its efforts to make everything a casino?

We’re going to be talking to pediatrician Dr. Lauren Hughes about the major changes to the CDC vaccine schedule. We want your questions! Hit us up via email at whatnextTBD@slate.com or leave us a voicemail at 646-582-0091. 

Guest: Alex Kirshner, Slate contributing writer

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Podcast production by Evan Campbell, and Patrick Fort.

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After the Trump administration launched a massive Immigrations and Customs Enforcement operation in Minnesota, protesters gathered to defend immigrant neighbors. Renee Nicole Good, a mother of a six year old, showed up with her wife and dog to film altercations between officers and community members. What happened next changed everything. 

Guest: Jon Collins, senior reporter on the Minnesota Public Radio News race, class and communities team.

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Podcast production by Ethan Oberman, Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme and Rob Gunther. 

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If you were to sum up 2025 in a film, which would you pick? The question that nearly wrecked the brain of Slate’s chief movie critic.

Guest: Dana Stevens, Slate’s movie critic.

Dana’s ten best movies of 2025.

Her review of Sinners.

And her review of One Battle After Another.

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Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther.

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Over three different trips during the war, this doctor saw the chaos of blast injuries in northern Gaza give way to gunshot wounds suffered at aid-distribution sites in the south. 

Guest:  Dr. Mohammed "Adeel" Khaleel, minimally invasive and complex spinal surgeon with Texas Metroplex Institute for Sports Medicine & Orthopedic Surgery.

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Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther.

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This week we look back on some of our favorite stories from a year that had us asking—sometimes with excitement and sometimes with exasperation—"What Next?" This episode originally aired March 21.

A very strange bankruptcy case is coming to a close. Its settlement hinges not on payments rendered or bills neglected, but on the pain of millions of American families who slid into the jaws of the opioid crisis. Now, the people who set off the crisis are about to settle their debts.

Guest: Brian Mann, reporter on addiction for NPR.

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The Food and Drug Administration gave an important thumbs up to lab-grown chicken, which means we could start seeing it in stores as soon as next year. While billions of dollars have been spent developing lab-grown meat, important questions remain: Is the production of it actually greener than raising livestock? Can it be made affordably? Is it healthy? And will anyone eat it?

Guest: Chloe Sorvino, staff writer on food and agriculture at Forbes, and the author of Raw Deal: Hidden Corruption, Corporate Greed and the Fight for the Future of Meat.

Host: Lizzie O’Leary

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Even in a crazy year for crypto, Sam Bankman-Fried’s story is undeniably the most bananas. And even in the context of the implosion of FTX, getting arrested has got to make this week his worst yet. What charges does SBF face?

Guest: Stacy-Marie Ishmael, managing editor on crypto for Bloomberg News

Host: Lizzie O’Leary

Sponsored by Saks.com. Check out the Holiday Gift Guide on saks.com

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The Reichsbürger movement is the group behind the plot to overthrow the German government that was disrupted last week. Their grievances are both specific to their country—that the German government is illegitimate and the Reich needs to be reestablished—and familiar to right-wing extremist watchers in the U.S.. They have been radicalized by lockdowns, vaccine requirements, and Qanon. How is this American conspiracy exporting itself? 

Guest: Josh Keating, global security reporter at Grid focused on conflict, diplomacy, and foreign policy.

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Since its founding in the 1980s, the Federalist Society has been advancing right-wing judges through the American judicial system. One of their most ardent critics called up a member to talk about how.

Guest: Mark Joseph Stern, Slate senior writer.

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Argentina and Croatia face off in the World Cup semifinals today, and all eyes are on Lionel Messi. At 35, Messi is trying to put a cap on a legendary career and bring a World Cup championship to his home country. 

How did he get to the top of the soccer world? And what will be his legacy if Argentina loses?

Guest: Jasmine Garsd Garcia, host of NPR’s soccer podcast “The Last Cup.” 

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In an effort to address New York’s growing problem of unhoused people living on the streets, Mayor Eric Adams announced that the city would start involuntarily hospitalizing people. It’s a strategy the city tried back in the ‘80s as well. Why didn’t it work then?

Guest: Sam Tsemberis, founder and executive director of Pathways to Housing, and associate clinical professor of Psychiatry and Biobehavioral Sciences at UCLA.

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Self-driving cars and robotaxis are starting to appear on the streets of San Francisco. While we have a whole regulatory system in place for drivers, who’s making sure these new cars are safe?

Guest: David Zipper, Visiting Fellow at the Harvard Kennedy School's Taubman Center for State and Local Government

Host: Lizzie O’Leary

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Artificial intelligence is growing in leaps and bounds, and everywhere from Big Tech companies like Google to small teams like OpenAI are developing more and more convincing chatbots. Is the world ready for convincing, talking computers? 

Guest: Alex Kantrowitz, host of the Big Technology podcast.

Host: Emily Peck

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Toomaj Salehi, an Iranian rapper known for criticizing the regime with his music, has been arrested by the Iranian government. His friends and family now worry he could face the death penalty. 

Guest: Nahayat Tizhoosh, Producer at the CBC.

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American agriculture relies on foreign workers, and they rely on the H-2A visa program to work legally in the United States. Despite a growing number of people applying for visa spots, the Trump administration has proposed cutting the division of the Department of Labor that enforces H-2A rules, leaving workers to choose between being vulnerable to ICE or to exploitation. 

Guest: Max Blau, ProPublica reporter covering health care, the environment, agriculture and immigration.

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Three botched lethal injections in Alabama have once again highlighted the practical complexity and possible illegality of the death penalty. Even states that are adamantly in favor of capital punishment are being stalled on a purely pragmatic level. 

Guest: Elizabeth Bruenig, staff writer at The Atlantic

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Even after a campaign awash in scandals, gaffes, and the occasional speculation on werewolves vs. vampires, Herschel Walker still can’t be counted out in the run-off election to represent Georgia in the U.S. Senate. What can the parties take away from the last race of the 2022 midterms? 

Guest: Jim Newell, Senior Politics Writer for Slate.

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The U.S. has welcomed thousands Afghan refugees since pulling out of Afghanistan in 2021. Safe from the Taliban, but without social security numbers,credit ratings, or even sometimes basic English, they have to make a new life relying on a patchwork of volunteers and their wits.  

Guests:

Elena MacFarlane, volunteer with the Immigrant and Refugee Outreach Center and assistant Professor in the Johns Hopkins Department of Genetic Medicine.

Lila and Basheer, Afghan refugees living in Maryland.

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The Biden administration’s Department of Justice and Federal Trade Commission are both staffed with accomplished progressives who are proving more aggressive than their predecessors in either the Trump or Obama eras. But can Big Tech be tamed?

Guest: Leah Nylen, reporter for Bloomberg News 

Host: Lizzie O’Leary

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Dating back to the Arab Spring, Twitter’s potential for real-time organizing has been a selling point. But trying to find information on China’s “Zero COVID” protests reveals just how vulnerable the now-understaffed platform is to manipulation.

Guest: Joseph Menn, cybersecurity reporter for the Washington Post. 

Host: Lizzie O’Leary

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For nearly three years, people in China have endured their government’s “Zero COVID” policies to prevent cases from overwhelming their hospital system. But after a fire in Urumqi broke out and videos spread of fire rescue having trouble reaching the building, people have taken to the streets in defiance of orders and even gone as far as demanding President Xi Jinping’s resignation. 

Guest: Matthew Brazil, co-author of Chinese Communist Espionage: An Intelligence Primer and a fellow at the Jamestown Foundation.

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With no clear path to advance and winter settling in, what would it take for Russia to negotiate an exit from Ukraine?

Guest: Fred Kaplan. Slate’s war stories correspondent

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With Yale and Harvard law schools withdrawing from U.S. News & World Report’s annual law school rankings, others have followed suit. With the rating system for all colleges taking criticism, being “gamed,” and beset by scandal, is this the beginning of the end of the influential college-ranking system?

Guest: Colin Diver, the Charles A. Heimbold, Jr., Professor of Law and Economics Emeritus at the University of Pennsylvania, former Dean of Penn Law School and president of Reed College, 2002 through 2012. 

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Hakeem Jeffries appears set to take over as Nancy Pelosi steps down as the head of the House Democrats. As a member of the Progressive Caucus who has often sided against progressives with party leadership, what will the House Democrats look like with Jefferies at the helm? 

Guest: Alex Sammon, politics writer at Slate.

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The option to “buy now and pay later” over installments exploded over the past two years, thanks to people being flush with stimulus cash and shopping online during the pandemic. But is this new, underregulated industry a useful line of credit or another path into debt?

Guest: Paulina Cachero, personal finance reporter for Bloomberg.

Host: Lizzie O’Leary

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Media giants like Paramount and Disney have been swift to capitulate to the Trump administration and the tenacious head of the FCC, Brendan Carr. Why new ownership from the likes of the Ellisons is likely to make things worse.

Guest: Nitish Pahwa, staff writer for business and tech at Slate.

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Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther.

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When presale tickets for Taylor Swift’s upcoming tour effectively broke the internet last week, Ticketmaster emerged as the villain…again. The media behemoth has been reviled since the ‘90s, but it has continued to grow, through a merger with Live Nation. What can a Department of Justice antitrust investigation, buoyed by Swifties, actually do? 

Guest: Jason Koebler, editor-in-chief of Motherboard at Vice.

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During the 2022 midterms, four states voted to ban slavery, which is still legal—and practiced—in the form of forced prison labor. The ballot initiatives are designed to keep people from having to work against their will and could provide prisoners with the opportunity to sue for higher wages, and better working conditions, including medical exemptions for those who are pregnant and postpartum. 

Guest: Candace Bond-Theriault Esq., Director of Racial Justice Policy & Strategy at Columbia Law School’s Center for Gender & Sexuality Law. 

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Fentanyl has been a right-wing boogeyman and ostensible reason for Republicans to rail for more security at the U.S.-Mexico border. As the opioid crisis continues, the danger fentanyl poses has become vividly clear. While stopping overdoses is important, resurfacing nasty drug war tropes isn’t helping. 

Guest: Brian Mann, NPR correspondent covering addiction

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After decades as America’s booming industry, tens of thousands of tech workers have been laid off in November alone. Is the venture-capital, low-interest-rate wind leaving the sails temporary or is this the end of the hunt for “the next big thing?”

Guest: Timothy B. Lee, reporter for Full Stack Economics covering labor markets, technology, and housing.

Host: Lizzie O’Leary

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At this year’s annual UN conference on climate change, they are discussing “climate reparations,” wherein the rich countries that grew their wealth burning fossil fuels pay money to poorer and more vulnerable countries. It sounds sensible, but is the UN capable of administering something like this? And how much money are we talking here?

Guest: Vijay Vaitheeswaran, global energy and climate innovation editor at The Economist.

Host: Lizzie O’Leary

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State supreme court elections, for a long time, were an afterthought; filler for the ballot’s second page. But with questions of abortion rights on the line, this year both parties started pouring money and attention on the races across the country. Even where the races are explicitly “non-partisan,” the partisan political machine has arrived. 

Guest: Erik Ortiz, staff writer for NBC News focusing on racial injustice and social inequality.

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The Supreme Court case Brackeen v. Haaland concerns how adoption placement currently works under the Indian Child Welfare Act. The law prioritizes placing Native children with Native families. But depending on how the court rules, striking down or changing ICWA could affect not only adoption but Indian tribes’ entire status as sovereign nations. 

Guest: Elizabeth Hidalgo Reese, Stanford law professor and scholar of American Indian tribal law, federal Indian law, and constitutional law.

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After bracing themselves for a “red wave,” the Democrats will keep their Senate majority after the midterms. However, the Republicans will likely, narrowly take the House, thanks in part to gains made in deep blue New York State. How did the party bungle this so badly? And why do some Democrats say it’s Andrew Cuomo’s fault?

Guest: Jimmy Vielkind, reporter for the Wall Street Journal covering New York State politics and government.

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Though just last year he was ousted from office amidst corruption charges, Benjamin Netanyahu has returned to power, leading a coalition of three hard right-wing parties. Palestinians inside Israel are concerned that some of their leaders are now emboldened in their goal of expelling Arabs from the country.

Guest: Peter Beinart, professor of journalism and political science at the Craig Newmark Graduate School of Journalism at the City University of New York and an editor-at-large at Jewish Currents.

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The (once) third-largest cryptocurrency exchange, FTX, collapsed in stunning fashion this week, highlighting why consumers really do want regulation, and why old financial institutions remain wary of crypto.

Guest: Felix Salmon, host of Slate Money, chief financial correspondent for Axios.

Host: Lizzie O’Leary

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If you’re hunting for a job, the odds are increasingly likely you’ll have an interview with an artificial intelligence “recruiter.” And why not? It’s also increasingly likely you’ll be working with A.I. anyway. 

Guest: Danielle Abril, technology-in-the-workplace reporter for the Washington Post.

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The second largest investor in Twitter, after Elon Musk, is the Saudis, which raises questions about what kinds of “free speech” Musk is really committed to. But it also raises questions around national security in the U.S. 

Guest: Chris Murphy, U.S. Senator from Connecticut

Host: Lizzie O’Leary

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The dust still hasn’t settled from the midterm elections. But some themes have begun emerging: the GOP underperformed; the right to abortion won on state-level votes; Florida has gone red, but Democrats won gubernatorial races across the old “blue wall.” And it may be time for Republicans to consider who they are, apart from the party of Trump.

Guest: Jamelle Bouie, columnist at the New York Times.

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As Texas laws have become more discriminatory against trans individuals and their families, many wonder if they can even stay in the Lone Star State, especially when parents could be investigated as child abusers for providing healthcare to their children. This family made the difficult decision to move to Colorado. 

Guests:

Katie Laird, social justice blogger.

Noah Laird, high school junior.

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Paul Pelosi joined a growing list of Congress members and their families who have been targets of violent political attacks. What can be done about the growing safety risk of being in the public eye? And what does living under threat do to the people charged with running the government?

Guest: Liz Goodwin, Congress reporter at the Washington Post.

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Trump won Ohio handily, and it’s been expected that JD Vance would cruise into a Senate seat this fall. But Democratic candidate Tim Ryan seems to have struck a chord with the very demographics that have been drifting away from his party. Does he have what it takes to win in Trump country? And could his success be replicated across the Midwest?

Guest: Alec MacGillis, politics and government reporter at ProPublica.

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It’s been a rough autumn for parents of little kids, as non-COVID respiratory diseases are taking advantage of the first fall since 2019 where schools and daycares are full again, and America’s strained pediatric health care system is once again put to the test. 

Guest: Katherine Wu, science writer for The Atlantic.

Host: Lizzie O’Leary.

Podcast production by Madeline Ducharme.

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One week in as head honcho of Twitter and Elon Musk is in a tight spot: how do you balance the desires of advertisers with your ostensible zeal for free speech? How do you make something for which you’ve already overpaid turn a profit? How do you convince Stephen King to pony up for a blue check?

Guest: Alex Kirshner, contributing writer at Slate. 

Host: Lizzie O’Leary

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Podcast production by Madeline Ducharme.

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Democrats have been winning reliably in Nevada, but between the lack of enthusiasm for Joe Biden among Latino voters, and a lackluster voter-turnout effort from Vegas’s hospitality union, it’s very possible that the face of Nevada’s “Stop the Steal” effort may win a Senate seat.

Guest: Jon Ralston, CEO and Editor in Chief of The Nevada Independent.

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Joe Biden won Colorado by 13 points, which is why Jim O’Dea is running for the Senate as a moderate Republican—one who will stand up to Donald Trump. It’s a message that isn’t winning support from Democratic voters, and may well be undermining his appeal to Republicans.  

Guest: Jim Newell, senior politics writer at Slate. 

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Yesterday, the Supreme Court heard oral arguments in two cases challenging race-conscious admissions programs. If the justices decide that affirmative action is unconstitutional—as they seem poised to do—how can universities still create diverse student bodies? 

Guest: Mark Joseph Stern, senior writer at Slate covering the Supreme Court.

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TikTok—which was supposed to be banned again on Wednesday but, again, isn’t—may be legal once more. The Trump administration says it’s meeting with Xi Jinping Friday to finalize the agreement, which may involve—get this—a wealthy Trump-supporting tech mogul. 

Guest: Nitish Pahwa, staff writer for business and tech at Slate.

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According to the recently released results of the National Assessment of Educational Progress, American students across the country are scoring lower on math and reading. But before we panic, it’s important to put those results in context, and consider what evaluations can actually tell us.

Guest: Jack Schneider, associate professor of education at the University of Massachusetts Lowell and co-host of the education policy podcast “Have You Heard.”

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There are some 400 million surveillance cameras installed in China, one for every three to four civilians. Built with the help of American tech companies, the surveillance state was pitched to the public as a way to make society safer and more efficient. But after severe lockdowns during COVID, the public has been objecting out of the eye of the camera lens. Protests are being written on bathroom walls.

Guest: Josh Chin, deputy bureau chief, China, for the Wall Street Journal

Host: Lizzie O’Leary

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