That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun), what I should be doing in the fall (writing), and what kind of episodes you can expect. I'd like to call it To Health With That! Season One BONUS Episodes.Thanks so much for being here and adding so much in terms of comments and questions - I couldn't do this without you.In September we'll have occasional episodes about methylation and MTHFR, maximum safe doses of methyl folate, methylation adaptogens, and a few other big topics that come up.Agent? Editor? Just have a comment? Email me! amy @ tohealthwiththat.comIn the season four finale of the 'To Health With That' podcast, host Dr. Amy Neuzil wraps up the season which focused on fatigue - discussing its causes and solutions. She announces a summer break for listeners to enjoy, expressing gratitude for their engagement and inviting them to stay in touch. Amy reveals plans for a reduced schedule next season due to her focus on writing a book, with occasional bonus episodes centered on MTHFR and methylation. Amy also expresses interest in connecting with agents and publishers for her book project and promises updates in the future. The podcast will return with irregular episodes and content mainly focused on MTHFR and methylation topics.00:00 - Intro00:35 - Season Four Wrap-Up and Summer Plans01:09 - A Heartfelt Thank You and How to Stay in Touch01:32 - Looking Ahead: Season One Bonus Episodes and Book Plans02:40 - Signing Off: See You After the Break!GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.comFREE COURSE: MTHFR Basics: ⁠https://www.tohealthwiththat.com/free-tools⁠WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you!SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt

Gentle MTHFR Detox ProtocolA gentle six-week detoxification protocol tailored for individuals with MTHFR polymorphism. She explains how decreased methylation in MTHFR polymorphism sufferers leads to toxin accumulation and stresses the importance of detoxification. The protocol includes preparatory steps, recommended supplements like NAC and liposomal glutathione, dietary adjustments, and lifestyle changes aimed at supporting the body's detox process. Additionally, she discusses the health benefits of detoxification, such as weight loss and improved sleep, and provides practical tips for easing into detox. The episode also addresses potential detox symptoms and the importance of consulting with a practitioner before starting the protocol.Here's the protocol in written form so you don't have to take notes: https://www.tohealthwiththat.com/post/gentle-six-week-detoxification-protocol-for-mthfr

GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.comFREE COURSE: MTHFR Basics: https://www.tohealthwiththat.com/free-tools⁠WEBSITE (check out the free tools section!): https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you!SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt00:00 - Intro00:30 - Why do a detox02:07 - Detox Essentials: What You'll Need03:45 - Pre-Detox Preparation: Weeks 1 and 207:02 - The Active Detox Phase: Weeks 3 to 610:21 - Closing Thoughts and Community Invitation

Problems with oxygenation can affect your sleep quality and quantity, leaving you feeling tired, or like you slept but woke up as tired as you were the night before, or just plain exhausted.Iron deficiency and carbon monoxide poisoning are both oxygen problems, not that we think of them that way, but many oxygen problems are more subtle. The classic oxygen problem overnight is sleep apnea, which causes you to wake up through the night becuase you stop breathing momentarily.Mouth breathing at night also impairs oxygen and leads to fatigue, low energy, and a poor night's sleep. My favorite solution to this problem is mouth taping.00:00 - Intro00:40 - Iron deficiency and carbon monoxide poisoning01:55 - Sleep Apnea02:21- Types of Sleep Apnea03:08 - Sleep apnea treatment03:36 - Sinuses and fatigue04:07 - Mouth breathing and fatigue05:15 - Why mouth breathing causes fatigue05:45 - Three differences between breathing through your nose and mouth07:05 - Fix mouth breathing with mouth tapingThanks so much for for watching or listening. Here are some other links that you might like.

The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠

Genetic Rockstars - a community for people making the most of their favorite genes and getting better together ⁠https://community.tohealthwiththat.com/⁠

FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

When you're working with MTHFR and following a good plan, you start to feel better from day one. But that doesn't mean that day 38 isn't kind of icky. There are bad days and that's part of the journey, but why? What is really happening when these bad days jump out at you? We'll talk about:

• Your bucket
• Your backlog
• Working with both of those
• Some tools you can use to fix bad days.
• Why symptom tracking makes all the difference.

If you want a free symptom tracker, sign up for my newsletter here for a free download, or join the MTHFR community Genetic Rockstars and find your free symptom tracker in the MTHFR Library - a whole bunch of free resources just for the community.

This is a big journey - how do you know when you're there? In good news, there are two main ways. This week, we'll talk about:

• Signs and behaviors that indicate your methylation is balanced
• What to do if you need a more concrete answer
• Three lab values that matter
• A few lab values that don't matter so much (in my opinion).

The most important thing is to let the journey happen. You can't really rush this one! I'd love to see you in the free MTHFR community Genetic Rockstars, or even, if you want a little bit more support, in MTHFR Academy - a dedicated MTHFR coaching community.

This week we've got some questions from listeners - all about MTHFR. We'll talk about:

• What to do if you want to work with Amy.
• The three different options and how to find them.
• How MRI Contrast medium might be different for MTHFR folks
• What mamas nursing MTHFR babies should do about MRIs
• How to ask a question of your own. I'll try to do answer sessions once a month.

If you do have a question, go to https://tohealthwiththat.com and scroll down the page about half way. You'll se a video of me, asking you for your questions. You can ask your question in video, audio, or written format. Thanks so much to Sandy and Sam, who asked this week's questions.

If you're interesting in joining Genetic Rockstars, our amazing MTHFR community, go to community.tohealthwiththat.com

We've all heard so many  things we're supposed to do to be happy, but do you know anybody who actually does them? This week we'll talk about simple joyhacks, most of which take five minutes or less, that have been shown by science to boost your happiness. We'll talk about:

• A two-minute trick with a pencil (no joke!)
• Why smaller, achievable goals boost your joy more than bigger, shinier ones.
• A great reason to visit an art gallery, take a hike, or play in the park.
• Why the little stuff matters more than the big stuff.

I hope you'll join us in Genetic Rockstars because, IMHO it's the most amazing group of MTHFR folks on the internet. Hear other people's stories, share laughs, take a course like the 10-week MTHFR 101, or even join group coaching in the MTHFR Academy. It's all waiting for you at community.tohealthwiththat.com

Research has mostly shown that mental health issues often correlate with imbalance in neurotransmitters and so that idea has been locked in socially. We have painted ourselves into a corner in which ALL mental health issues must be neurotransmitters. This week, we'll talk about:

• Four reasons why it might not always be about neurotransmitters.
• Why the word "depression" might mean something different to everybody.
• How the mechanistic model fails in neurotransmitter balance.
• Amy's theory on neurotransmitters.

This week you can see the complete show notes here, and you can check out our amazing MTHFR community, Genetic Rockstars, here.

One more episode in our mini-series on neurotransmitters, MTHFR also affects your levels of norepinephrine and its metabolite, epinephrine. We'll discuss:

• The only two neurotransmitters that are also hormones and what that means.
• Why too high norepinephrine looks like you've taken too much cocaine.
• The sloth of too low norepinephrine.
• A few simple things you can do to boost or quench your norepinephrine and epinephrine.

If you'd like to see the full show notes you can find those here.  Also, I'd love it if you'd join me in the MTHFR community, Genetic Rockstars.

In our little mini-series on MTHFR and neurotransmitters, we'll move on to discuss the relationship between MTHFR and dopamine. We'll talk about:

• The unlikely first symptoms you might see of low dopamine levels
• Why banana smoothies might help with dopamine related weight gain (like after you quit smoking)
• The issue with dopamine receptors
• And how to boost your levels without drugs.

For the complete show notes including links to related concepts (like our post on serotonin, or the BH4 connection) you can click here. If you can't wait to join the MTHFR community, Genetic Rockstars, or take an MTHFR 101 course, click here. Thanks for listening! Don't forget to subscribe or leave a review so other people can find great information to help them on their MTHFR journey a little bit more easily.

MTHFR is tangled up with neurotransmitters via its direct link with the BH4 pathway, which is where most neurotransmitters are made. So let's talk about MTHFR and serotonin. This week we'll go over:

• The surprisingly mixed evidence with serotonin and depression.
• The first thing you should do to boost serotonin with MTHFR.
• Low serotonin symptoms you might never think of.
• Some amazing serotonin boosters that are all natural.

Thanks for listening today and if you'd like the complete show notes with links to resources, they're here.  Also, if you want to be a Genetic Rockstar too, click here.

Decision fatigue is the weary, burned out feeling that comes from the constant burden of too many choices. Simple choices and consequential ones all add into this issue, but today we're talking about some strategies especially for the decision fatigue that comes along with MTHFR and any other chronic health issue. We'll discuss:

• 4 red flags that tell you you're in decision fatigue territory.
• 7 ways to minimize decision fatigue in your health or any other area of your life right now.
• How the 80-20 rule can simplify your life.

Thanks for listening and if you're looking for the complete show notes, click here.  If you know or suspect you have an MTHFR issue and want to join an amazing community of people who are getting better together, join Genetic Rockstars today at community.tohealthwiththat.com.

This is our most frequently asked question in Genetic Rockstars, the MTHFR community, so I figured we'd better have a conversation about it. This week we'll discuss:

• The four most common forms of B12 available
• Which forms are active
• Which form is already methylated
• The form that can have the most side effects for MTHFR folks
• The form that needs to be detoxified as well as methylated.

B 12 is pivotal to the MTHFR journey, so it helps to know your stuff before you buy. You can see the full show notes here, and if you're pretty sure you should be a Genetic Rockstar (because I'm pretty sure you need to be,) click here.

Sex hormones have a lot to do with how energetic you feel, or how sleepy, or how grumpy. So, let's talk about how estrogen ties into sleep, weight, and metabolism. How progesterone helps insomnia and gets stolen by stress hormones. Also, how testosterone is a feel-good chemical. We'll also talk about xenoestrogens, which come from outside your body, and how to reduce estrogen, boost progesterone and testosterone, and generally find hormone balance.00:00 - intro00:29 - What sex hormones do00:59 - Estrogen and metabolism01:40 - Estrogen dominance02:03 - Xenoestrogens (estrogen from chemicals)02:25 - Two ways to manage estrogen levels02:30 - Avoid estrogen from chemicals03:43 - Detoxify estrogen better03:53 - Estrogen detox needs good methylation05:00 - Progesterone, sleep, and stress06:25 - Testosterone and wellbeing07:04 - High estrogen causes low testosterone07:48 - Men need weight bearing exercise08:02 - Losing weight leads to estrogen spikes08:20 - Supplements for Testosterone08:38 - Energy changes in menstrual cycle09:26 - The bottom lineThanks so much for for watching or listening. Here are some other links that you might like.

The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠

Genetic Rockstars - a community for people making the most of their favorite genes and getting better together ⁠https://community.tohealthwiththat.com/⁠

FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

These two amazing research studies are actually measuring how active the MTHFR gene is and how Omega-3 fatty acids from fish oils change that. We'll talk about:

• B vitamins and omega-3s together and what happens to homocysteine when you take them.
• The remarkable effects of omega-3 for pregnant women with MTHFR.
• Why EVERY pregnant woman with MTHFR should take fish oils.

Thanks for listening and if you want to see the full show notes or diagrams of how the different enzymes fit into the homocysteine cycle, they're here.

Research is starting to show that some magic happens between B vitamins and fish oils, or omega-3 fatty acids, that allows the two of them together to work far better than either one alone.  Especially in areas that are of some concern to MTHFR folks, like cognitive decline, homocysteine levels, and inflammation. What is the magic here?

You can check out the full show notes here: MTHFR, B Vitamins and Fish Oils. Also, check out our amazing community of MTHFR folks just like you, here at Genetic Rockstars.

We've talked about the risks of homocysteine and optimal  levels and even the link between Covid-19 disease severity and Homocysteine, so now, let's talk about how to tackle the problem when your homocysteine is high. Let's learn about:

• Why it's important to remember you can have fleas and ticks on the same dog.
• Other causes of high homocysteine
• A step-by-step plan to get your homocysteine levels into optimal.

Thanks for  listening this week! If you'd like to see the full show notes, they are here. Also, a huge shoutout to all of the people who have joined me in the Genetic Rockstars MTHFR Community - I can't believe how amazing everyone is.

Ok - so we get that homocysteine is a problem for MTHFR folks. But what levels are we talking about here? In this episode we'll talk about:

• Important things your doctor might forget to tell you when you're getting your homocysteine tested.
• The normal range, and why in this case "normal" has little to do with optimal.
• What the research is beginning to show might be a more ideal range to shoot for.
• The unexpected risks of lowering your homocysteine too much.

We'll also talk a bit about Genetic Rockstars, our new MTHFR community full of incredible folks - I hope you join us there at community.tohealthwiththat.com  You can click here for the complete show notes.

In good-ish news, Covid-19 has been around long enough for us to get some DNA-specific research into the mix. Not much research has been done yet on Covid-19 and MTHFR, but we do have some data. We'll talk about:

• The link between C677T mutation, Covid-19 and mortality rates
• How high homocysteine might be a predictor of Covid-19 outcomes
• Why MTHFR folks are more susceptible to acute viral-related high homocysteine
• How MTHFR folks can protect themselves from the worst Covid-19 outcomes
• Why avoiding folic acid is even more important than ever.

Thanks for listening and come visit Genetic Rockstars, the MTHFR community at community.tohealthwiththat.com

It's really easy to get into the mindset that methionine is "good" and homocysteine is "bad" but the truth is so much more interesting than that! Let's talk about:

• The nutrients you are probably getting way too much of if you live in the West.
• How "boosting your protein" might be a failed strategy.
• The weird link between methionine and Covid-19
• Why MTHFR folks have to be extra careful about their protein intake.

Don't miss the detailed show notes here with all the protein requirements and if you're as excited about Genetic Rockstars as I am, click to join.

Homocysteine is usually the first thing that tips you or your doctor off to the fact that there may be an MTHFR mutation or an issue somewhere else in this genetic process. But what is the big deal? In this episode we'll talk about:

• The risks of having high homocysteine - it's not just about your heart (but heart attacks are a real problem, so don't underestimate that part).
• The link between MTHFR, B vitamins, and homocysteine
• The reason why homocysteine is actually necessary for your health
• The great thing about using homocysteine as a tool.
• An announcement about Genetic Rockstars - you don't want to miss that!

The complete show notes for this week with links to a *lot* of research, are here. 

We've had a few conversations about detox, but let's revisit some of these concepts in greater detail.

This week we'll talk about:

• The symptoms that can happen if you're pushing detox too hard.
• Why being emotionally "toxic" and physically toxic are eerily similar.
• Three lovely ways for MTHFR folks to detox without the drama and life-crises of detox kits.

If you're looking for the complete show notes with links to research, here they are. 

If you'd like to join the most amazing community of MTHFR folks on the internet, check out Genetic Rockstars.

Last week we talked about the idea of breaking mental bad habits and I gave you three tools you can use.

• The Fantasy
• The Stop and Drop
• The Distraction

So what happens when you actually start using these tools? Find out in today's episode. You'll learn about:

• The four phases of progress
• Why step two is vital, but feels like you're moving backward
• The science behind what seems so good it could only be witchcraft

For the full show notes, click here or visit tohealthwiththat.com

Let's talk about Overmethylation.

• Do overmethylators even need to have the MTHFR mutation?
• Unique gifts overmethylators bring to the world and the strengths of this group.
• The darker side of those gifts.
• Health risks that are more common in overmethylators.
• Drug and nutrient reactions that are more likely for the folks in this group.

For the complete show notes, look here. If you're not sure if you're an undermethylator or an overmethylator look here. If you want to sign up for the beta group of my MTHFR 101 class - email me at Amy @ tohealthwiththat.com (but leave out the spaces.)

There is nothing more frustrating than waking up in the middle of the night and not being able to go back to sleep easily. Nighttime waking is draining and exhausting, and you wake up feeling like you might as well not have bothered with all of those hours of tossing and turning. So, what can you do to help you sleep through the night without waking up? Let's talk about some options.00:00 - Intro01:13 - Time release melatonin02:23 - Night-time blood sugar spikes02:35 - Dawn Phenomenon03:08 - Night waking with "normal" blood sugars03:31 - Diet changes for blood sugar overnight04:05 - Supplements for overnight blood sugar05:00 - Prescription changes for nighttime waking in diabetes05:19 - Night-time cortisol spikes06:23 - Supplement to manage overnight cortisol07:07 - Histamine spikes at night07:46 - Supplements to lower histamine at night08:18 - Hormones and insomnia09:04 - Supplements to help preserve progesterone

This week we're expanding on the conversation about other factors in depression and talking about the single most overlooked factor in mental health - bad habits. Mental bad habits are a fact of life, but we'll talk about three different techniques to break them.

1. The fantasy
2. The stop and drop
3. The distraction

We'll also talk about how these bad habits form to begin with and what neuroplasticity has to do with all of it.  Click here for the complete show notes and next week we'll finish the conversation with a little bit more on what to expect when you're starting to use these life hacks.

Depression isn't an MTHFR problem, it's a human problem. Having said that, there are lots of ways MTHFR can contribute and the best news is, they're mostly fixable. In this episode we'll talk about:

• The two contributors to depression that every parent of a toddler understands.
• How balancing your methylation can help reduce five potential contributors to depression.
• Why when your doctor "runs out of drugs to try," you still have a bunch of options.

For the complete show notes (with links to buckets of research) click here.  If you want to join me in the beta group for an MTHFR 101 course, email me at amy at tohealthwiththat.com (except take out the spaces and replace the word "at" with the @ symbol.) 

Undermethylation is the most common MTHFR basic state, and it has its own unique strengths, challenges, and reactions to the world. In this episode you will learn:

• The amazing things about undermethylators that have helped them push their dreams into the world.
• The three most common health issues undermethylators face.
• Drugs and supplements to which  undermethylators tend to react badly.
• The link between undermethylation and histamine.

For complete show notes, follow this link. If you're not sure if you're an overmethylator or an undermethylator, follow this link. If you're interested in being part of the beta group of MTHFR 101, email me at amy at tohealthwiththat.com (but without the spaces, and replacing the "at" with @).

Healing can be a messy process, but by using a systematic approach you can avoid some of the craziness. In this episode we'll talk about:

• Supplement Soup, and how to avoid it.
• The three phases for working with MTHFR
• The four piles you should put your supplements into (and which ones you can toss).
• The beta group for Amy's new MTHFR 101 course - launching this spring, and how you can be a part of it.

The complete show notes can be seen here. Thanks for listening!

This week will help you to get a mental image of how all of your tiny stressors end up turning into symptoms your body. It's an MTHFR fairy tale (don't worry, there's a happy ending.) Remember - the goal is to empty your bucket. :)

The full show notes can be seen here: https://www.tohealthwiththat.com/the-bucket-theory-and-mthfr/

Let's face it - MTHFR goes hand in hand with allergies and sensitivities in a number of different forms. In this episode, we'll talk about:

• The four known links between MTHFR and allergies.
• The four types of allergies or sensitivities that are common for MTHFR folks.
• How these sensitivities can be a strength, if you can harness them.

For details about the upcoming MTHFR community, follow this link. And for the complete show notes with links to research, click here.

This episode resulted from a great question from listener Jane Turner - thanks, Jane! We'll talk about:

• MTHFR and Tylenol (or paracetamol, or acetaminophen - just depending on what country you happen to be in)
• MTHFR and NSAIDS (or non-steroidal anti-inflammatories)
• Surprising information about MTHFR and aspirin
• The sad truth about MTHFR and opioid medications
• One commonly used anesthetic that is not a great idea for MTHFR folks
• A quick look at some alternatives for chronic pain

Thanks for listening and you can find detailed show notes with links to the research, here.

The internets get hugely focused on particular mutations, so here's my nod to A1298C. In this episode we'll talk about:

• What makes a difference in your clinical outcomes according to research and my own clinical practice
• What doesn't (that matters just as much!)
• The confusing nomenclature of A1298C and what it all means
• The one factor that is far more important than your particular mutation
• A superpower that might be specific to A1298C mutations - although it's anyone's guess why.

If you're interested in seeing the show notes, they're right here.

This episode might surprise you! This week we'll go over:

• The bizarre and confusing array of names for the C677T mutation
• The gaps in current research
• How much you can trust the research regarding enzyme activity and level of compromise
• The two factors that actually matter about the mutation
• Which information reigns supreme, clinically speaking - your mutation or your basic over/undermethylation state.

You can see the complete show notes and links to all of the research here. Don't forget to give me a thumbs up or a high-five or a bunch of stars or some kind of smiley face or four tomatoes or whatever it is I'm supposed to be getting. Help other mutants find some good info! :)

Detox is for life, at least it is if you, like me, have an MTHFR situation.

In this episode we'll discuss:

• Why detox kits are not always the best for us (it isn't the answer you're expecting)
• Three strategies for ongoing gentle detoxification
• What a "gut sponge" actually is
• And the unsexiest detox topic.

Thanks for listening and if you'd like to see the full show notes, you can click here. Don't forget to subscribe!

Also, I totally busted 10 minutes this week, but I couldn't find anything to cut! Sorry folks, I'll do better next week. :)

Supplements to help you fall asleep are a big topic, and there are many to choose from, but these are my favorite supplements to get you to sleep faster.

Thanks so much for for watching or listening. Here are some other links that you might like.

The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠

Genetic Rockstars - a community for people making the most of their favorite genes and getting better together ⁠https://community.tohealthwiththat.com/⁠

FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

00:00 - Intro00:49 - Make sure you're not taking something that keeps you awake01:13 - Special precaution with MTHFR01:57 - Body won't relax02:28 - Magnesium03:15 - Opposite reaction to magnesium03:30 - GABA03:57 - Passionflower04:15 - Agitated mind04:34 - Valerian Root04:58 - Bifidobacterium longum 171405:42 - Aromatherapy06:23 - Chamomile06:58 - Glycine07:25 - Melatonin09:18 - Next episode

It's important to keep the goals in mind when you're working with MTHFR, but... what are they?

We'll talk about:

• Three concrete health goals to work toward 
• The misguided idea of perfection
• A gentler view of the aims with MTHFR

You can see the full show notes here, and sign up to the mailing list to get a free symptom tracker and some other free goodies at tohealthwiththat.com

Starting methylfolate can be a rocky road, so it helps to know what is a normal part of starting and what is a signal that something has gone wrong somewhere. In this episode we'll talk about:

• When ups and downs matter.
• Signs and symptoms that you're pushing detoxification too hard.
• Why detoxification is even involved in this.
• How to support your body through different scenarios.

The complete show notes are here and keep your eyes and ears open for an upcoming course announcement!

Dosing 5-LMTHF isn't typically just finding a right dose and sticking with it until you die.  Typically, you have to be able to roll with the punches. In this episode, we talk about three different dosing strategies.  My favorite, intuitive dosing, Dr. Ben Lynch's Pulse Method, and a mixed strategy. We'll discuss:

• The three things you actually do have to take regularly.
• Who might not do well with intuitive dosing.
• The best strategy for people who thrive on routine.

For the full show notes, follow this link.  Don't forget to subscribe and leave feedback.

This is, of course, what everybody wants to know first thing out of the gate, before they do anything else with MTHFR, so let's talk about it. This week we'll discuss:

• The three things you should already be doing before you start 5-LMTHF.
• The three rules for starting any supplement effectively (but especially methylfolate)
• The three types of reactions you can expect with methylfolate
• What to do if you don't tolerate it.

Be sure to sign up for the mailing list on our website because we're sending out lots of freebies with more information about the topics we cover. Also, you can see the full show notes here along with links to more information about other concepts we've discussed. Thanks!

Of course MTHFR is about folate, but the whole methylation pathway is so vital to your health, that lots of other nutrients are tied up in this process, too. Today we'll discuss:

• What nutrient you absolutely must take if you've got non-alcoholic fatty liver disease (NAFLD), which is shockingly common in MTHFR folks.
• What food source of magnesium has convinced Amy that there is a God.
• How much the nutritional value of our food has declined in the last century (it's shocking. Absolutely shocking.)
• Which nutrient is especially important if you're making babies.

For the complete show notes with links to research, see this page on tohealthwiththat.com. Also, if you're new to MTHFR, check out our Start Here guide.

The question of whether you're moving to health or disease is a silly one, right? Of course you know. Except with MTHFR, this might be tricker than you think. In this episode we'll talk about:

• Finding your own MTHFR red flags that are your early warning signs that you're going in the wrong direction.
• Why I (Amy, your host) am in love with symptom trackers.
• How to use a symptom tracker.
• The tricky MTHFR red flags that disguise themselves as "positive traits."
• The four types of signs and symptoms you should be tracking for MTHFR.

I hope you enjoy and if you're looking for the show notes, click here.  Also, if you sign up for the mailing list you can download the free symptom tracker and a couple of other great freebies for MTHFR folks.

Folate is supposed to cure what ails you with MTHFR, so what happens if you just don't tolerate it... at all? This is a problem lots of MTHFR folks face, so in this episode we'll cover:

• The most crucial step if you don't tolerate folate - changing this one thing can fix something that has probably been making you feel worse your whole life.
• Two cheat work-arounds when folate isn't an option
• The difference between folate and SSRI medications
• The main categories of MTHFR folks who just don't do well with folate -  not even natural folate in foods.

You can see the full show notes here and access our Start Here for MTHFR page, here.

This is a topic of some debate among the MTHFR community, and one area where Dr. Ben Lynch and I have differing opinions. In this episode we will deep dive into:

• The ways your personality is shaped by your basic state.
• The archetypes of the basic states (are you the executive, the black sheep or somewhere in the middle?)
• Whether or not optimizing your methylation will change your essential personality and nature
• How to use your basic state as an in-the-moment sign of your methylation status

Click here for the full show notes with helpful graphics, links to research, and and an over- vs. under- comparison chart. If you want to reach out and let me know what your basic state is, I'd love to hear from you. amy at tohealthwiththat.com. Thanks!

MTHFR has its sticky fingers in almost everything and energy is no exception. Fatigue is one of the most common symptoms that MTHFR folks experience, but let's face it - it's one of the most common symptoms we all experience. In this episode we'll learn:

• The six factors that link fatigue and MTHFR
• Steps one, two and three to tackling fatigue
• Eight basic steps toward good sleep hygiene
• The best trifecta of sleep supplements
• Other factors to watch out for that might link in to low energy.

Don't forget to subscribe, like, leave feedback, tweet, insta, or whatever you do - I'd love to hear from you! For the complete show notes including links to all the relevant research, click here.

Glutathione is called the "master antioxidant," which sounds important, so obviously the MTHFR polymorphism is going to mess it up. In this episode we'll talk about:

• Why glutathione is the antioxidant of antioxidants.
• What diseases are associated with low glutathione (more than half of which are also associated with MTHFR. Guess why!)
• How to boost your glutathione naturally and effectively
• What foods help increase glutathione
• When it is most important to think about glutathione supplements.

You can click here for the full show notes and sign up for the mailing list at tohealthwiththat.com so you don't miss out on any freebies, give-aways or course announcements.

MTHFR gene mutations can create a lot of havoc in your life if they aren't properly managed and sleep disorders are just one of the many problems. This video will talk about the most impactful morning and evening sleep routines for MTHFR and also give some tips for the best diet to support great sleep in a person wtih the MTHFR gene mutation.Thanks so much for for watching or listening. Here are some other links that you might like.

The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠

Genetic Rockstars - a community for people making the most of their favorite genes and getting better together ⁠https://community.tohealthwiththat.com/⁠

FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

Chapters:

00:00 - Intro

00:35 - Methylation and sleep

01:00 - Mental factors in sleep problems with MTHFR

01:18 - Physical contributors to sleep problems with MTHFR

01:38 - Right folate plus right methyl donors

02:17 - How to find your perfect doses

03:09 - Synthetic folic acid and sleep

03:40 - Blood sugars and sleep

04:25 - Best bedtime routine for great sleep with MTHFR

07:16 - Best morning routine to help sleep with MTHFR

08:12 - Activities to include in your day for great sleep with MTHFR

If you know or suspect you have MTHFR or a methylation issue, be sure to subscribe to the podcast for health tips, MTHFR hacks and great information.

Even though we talk about folate *constantly* and don't seem to talk about any other vitamins, it isn't just about the folate. In this episode, we'll talk about:

• What entire group of vitamins works together to make methylation and cellular energy happen
• What other B vitamin is absolutely necessary for MTHFR to function - it might even be more important than folate!
• Amy's MTHFR story and why she's so absurdly passionate about this whole topic.

For complete show notes, follow this link - this post refers to chemical pathways and the visuals are in the show notes.

What we have here, is an MTHFR situation. In this episode we'll talk about:

• The three scenarios when taking the right kind of folate feels yucky
• What that might mean about you
• How to fix it

Easy-peasy-lemon-squeezie (as my 5-year-old says it.)

Here are the full show notes with links to more information.

Keep your eyes peeled for MTHFR courses - we're starting out with a Help! I've Just Been Told I Have MTHFR And I Don't Get It quickie class.

We've talked about the difference between natural folate and synthetic folic acid, but what does that mean in terms of eating for your MTHFR mutation? LOTS of things... Tune in to learn:

• The two foods that you absolutely should never eat, ever.
• The ten foods highest in natural folate that you can add to your diet today.
• Easy substitutions for foods that are fortified with folic acid.
• The big payoff to changing your diet.
• The two situations where a high-natural-folate diet might not be right for you (or, might be downright wrong).

Also - take a look at the show notes here for an MTHFR breakfast that will give you 77.5% of your daily folate needs. Easy.