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Explore every episode of the podcast This Week in Neuroscience

Dive into the complete episode list for This Week in Neuroscience. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

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1–50 of 71

TitlePub. DateDuration
TWiN 54: How pregnancy transforms the brain01 Oct 202401:05:25

TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.

Hosts: Vincent RacanielloJason Shepherd, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 53: Slowing time by cooling the brain29 Jul 202401:10:03

Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

Guest: Joseph J. Paton and Felipe Rodrigues

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Music is by Ronald Jenkees

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TWiN 44: ADHD and persistent pain02 Nov 202301:00:41

TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

Hosts: Vincent RacanielloJason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 43: Pavlovian opioid tolerance04 Oct 202301:02:41

TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.

Hosts: Vincent RacanielloJason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 42: Therapeutic effects of psychedelic drugs18 Jul 202300:56:34

TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.

Hosts: Vincent RacanielloJason Shepherd, and Timothy Cheung

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Download TWiN 042 (34 MB .mp3, 57 min)
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Music is by Ronald Jenkees

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TWiN 41: Alzheimer's and melanin-concentrating hormone20 Jun 202301:18:30

Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 40: Dopamine organizes behavior's syllables11 May 202301:04:17

Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 39: Virus-like capsids trigger paraneoplastic disease28 Apr 202300:52:39

Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu

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Music is by Ronald Jenkees

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TWiN 38: Bacterial immunity heals sensory neurons27 Mar 202301:04:57

TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.

Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 37: Microglia at the crossroads23 Jan 202301:15:05

TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 36: Unbearable neurologists03 Jan 202301:29:33

TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 35: Neuromodulation in treatment-resistant depression06 Dec 202201:09:13

Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. 

Hosts: Jason Shepherd and Timothy Cheung

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  • Closed-loop neuromodulation for depression (Nat Med)
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 52: Probiotic improves social behavior in children with ASD24 Jun 202401:05:50

Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.

Hosts: Jason ShepherdTimothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Music is by Ronald Jenkees

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TWiN 34: Microglia vital after spinal cord injury30 Sep 202201:09:17

TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 33: Viruses leaving the brain31 Aug 202200:58:11

TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 32: Relearning how to move after stroke02 Aug 202200:59:47

TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.

Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 31: HIV-1 co-receptor shapes window for memory linking29 Jun 202201:11:52

TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease24 May 202201:09:52

TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 29: Astrocytes close the critical period02 May 202201:02:05
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 28: Oligodendrocyte performance enhancing exosomes04 Apr 202201:13:59

TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 27: Eyes wired to the auditory cortex03 Mar 202201:03:47

TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.

Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 26: Immunological memory in the brain31 Jan 202200:53:49
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses.

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Music is by Ronald Jenkees

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TWiN 25: Thanks for listening28 Dec 202101:02:44

TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 51: Sensory processing dysfunction in autism spectrum disorders28 May 202401:11:20

TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. 

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke24 Nov 202101:12:47

Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin.

Hosts: Vincent Racaniello and Timothy Cheung

Guests: Ioana Carcea and Robert Froemke

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Music is by Ronald Jenkees

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TWiN 23: Peripheral nervous system with Bruce Carter31 Oct 202101:11:20

Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

Guest: Bruce Carter

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Music is by Ronald Jenkees

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TWiN 22: It's never lupus29 Sep 202101:08:17

TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 21: How do we know if a mouse is hallucinating?24 Aug 202101:28:02

TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.

Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung

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Music is by Ronald Jenkees

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TWiN 20: Drifting aromas in the brain14 Jul 202101:18:08

While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 19: Glia 10121 Jun 202101:12:54

On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli12 May 202101:10:52

Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Music is by Ronald Jenkees

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TWiN 17: Worms see the light with Michael Nitabach21 Apr 202101:21:59

Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Michael Nitabach

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Music is by Ronald Jenkees

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TWiN 15: Microbiome and neurodevelopment with Helen Vuong17 Feb 202100:49:33

Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

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Music is by Ronald Jenkees

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TWiN 50: Neurological sequelae after COVID-1929 Apr 202401:04:25

TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. 

Hosts: Vincent RacanielloJason ShepherdTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 14: Reducing Alzheimer-like pathology in mice14 Jan 202101:10:52

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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Music is by Ronald Jenkees

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TWiN 13: mRNAs for long-term memory15 Dec 202001:08:29

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Music is by Ronald Jenkees

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TWiN 12: A gene for short-term memory11 Nov 202001:12:57

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd   Subscribe (free): iTunesGoogle PodcastsRSS, email

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Music is by Ronald Jenkees

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TWiN 11: A dollar per neuron14 Oct 202001:06:21

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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Music is by Ronald Jenkees

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TWiN 10: Remodeling synapses with a cytokine29 Sep 202001:07:23

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

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  • IL-33 promotes synaptic plasticity (Cell)
  • Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 9: COVID-19 neurology with Genna Waldman11 Aug 202001:06:33

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

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Intro music is by Ronald Jenkees

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TWiN 8: Replacing lost neurons07 Jul 202001:11:25

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiN 7: Stress, the good, bad and beautiful13 Jun 202001:24:13

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiN 6: Neural control of sexual behavior20 May 202001:04:03

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd

Guest: Nirao Shah

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Intro music is by Ronald Jenkees.

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TWiN 5: Anosmia and COVID-1918 Apr 202000:58:53

Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello

Guest: Bob Datta

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Intro music is by Ronald Jenkees.

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TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?25 Mar 202401:31:25

TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. 

Hosts: Vincent RacanielloTimothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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TWiN 4: It's a trap!09 Jan 202001:08:15

Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.

Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello

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Intro music is by Ronald Jenkees.

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TWiN 3: Gambling on dopamine18 Dec 201901:20:59

Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.

Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello

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TWiN 2: Cells that fire together wire together05 Nov 201901:25:33

The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing.

Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent Racaniello

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Intro music is by Ronald Jenkees.

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TWiN 1: The ultimate challenge26 Oct 201900:43:51

The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Intro music is by Ronald Jenkees.

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TWiN 48: Traumatic brain injury and retroviruses19 Feb 202400:51:13

TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. 

Hosts: Vincent RacanielloJason Shepherd, and Timothy Cheung

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Music is by Ronald Jenkees

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