This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.
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Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Why I Believe Fish Oil's Big CV Benefit in Dialysis Patients https://www.medscape.com/viewarticle/why-i-believe-fish-oils-big-cv-benefit-dialysis-patients-2025a1000uzg
In Global Trial, PCSK9 Inhibitor Provides Major Protection Against First CV Event https://www.medscape.com/viewarticle/global-trial-pcsk9-inhibitor-provides-major-protection-2025a1000uzp
CAPITAL RCT trial https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
Beta-Blockers after MI with mildly reduced EF https://pubmed.ncbi.nlm.nih.gov/40897190/
John Cleland Clinical Outlook https://www.nature.com/articles/s41569-025-01228-w
IVLeft Atrial Appendage Closure – The CLOSURE-AF trial
Percutaneous LAAC in AF Falls Short Again in CLOSURE-AF https://www.medscape.com/viewarticle/percutaneous-left-atrial-appendage-closure-af-falls-short-2025a1000uzu
Anticoagulation After AF Ablation: The OCEAN Trial Still Leaves Questionshttps://www.medscape.com/viewarticle/anticoagulation-after-af-ablation-ocean-trial-still-leaves-2025a1000v4t
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Nov 07, 2025 This Week in Cardiology
Friday, November 7, 2025 • Duration 32:17
Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Meta-analysis of MI as a surrogatehttps://pubmed.ncbi.nlm.nih.gov/34694318/
FISH trialhttps://jamanetwork.com/journals/jama/fullarticle/1150094
III Obesity Agents
White House announces deal with Lilly and Novo on GLP-1 drugshttps://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/
Amylin Agonists
Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial
Sep 05 2025 This Week in Cardiology
Friday, September 5, 2025 • Duration 38:01
The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
This Week in Cardiology Podcast – August 29 https://www.medscape.com/viewarticle/1002877
II The Big Beta-blocker Story from ESC
Beta-Blockers Post-MI: A Clear Clinical Message https://www.medscape.com/viewarticle/beta-blockers-post-mi-clear-clinical-message-2025a1000mz0
REDUCE AMI https://www.nejm.org/doi/10.1056/NEJMoa2401479
CAPITAL RCT https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
Post Hoc Analysis From REBOOT Trial https://eurointervention.pcronline.com/article/effect-of-beta-blocker-withholding-or-withdrawal-after-myocardial-infarction-without-reduced-ejection-fraction-on-ischaemic-events-a-post-hoc-analysis-from-the-reboot-trial
Beta-Blockers After MI With Mildly Reduced Ejection Fraction https://doi.org/10.1016/S0140-6736(25)01592-2
CAPRICORN 10.1016/S0140-6736(00)04560-8 External Link
Aspirin Plus Oral Anticoagulants Raises Mortality, Bleeding https://www.medscape.com/viewarticle/aspirin-plus-oral-anticoagulants-raises-mortality-bleeding-2025a1000nam
Oct 06 2023 This Week in Cardiology
Friday, October 6, 2023 • Duration 23:42
Coated vs uncoated ASA, a new trial in CAD, conflicts of interest, first AF in the hospital, and changing HTN scoring and CHADSVASC are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. ASA
No Benefit of Enteric-Coated Aspirin vs Uncoated in CVD https://www.medscape.com/viewarticle/997119
- JAMA Cardiology: Coated vs Uncoated ASA https://jamanetwork.com/journals/jamacardiology/fullarticle/2809795
- Revascularization Choices Among Under-Represented Groups Evaluation (The RECHARGE Program) https://www.pcori.org/research-results/2023/revascularization-choices-among-under-represented-groups-evaluation-recharge-program
- Financial Conflicts of Interest in Public Comments on Medicare National Coverage Determinations of Medical Devices https://jamanetwork.com/journals/jama/fullarticle/2808721
IV. First AF in the Hospital
Decoding AFib Recurrence: PCPs' Role in Personalized Care https://www.medscape.com/viewarticle/997011
- Annals of Internal Medicine: AF Recurrence https://doi.org/10.7326/M23-1411
V. Changing CHADSVASC Score
- JAMA Network Open: HTN Guidelines and CHADSVASC Up-Scoring https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809933
Sep 29 2023 This Week in Cardiology
Friday, September 29, 2023 • Duration 26:06
Reader feedback, leadless pacing, ABIM, SGLT2 inhibitors, peri-operative MI after cardiac surgery, and. AHA late-breakers are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
Coronary calcium, cardiac arrest survival, Factor XI drug findings, APCs and a potential new board certification in cardiology are the topics discussed by John Mandrola, MD in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
Reader feedback, imaging in the cath lab, AF ablation to relieve anxiety, and some possible help in hypertension are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Reader Feedback
Sep 08, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/996233
First Clinical Trial of CTO Procedures Fails to Deliver https://www.medscape.com/viewarticle/877405
Parity for Prompt vs Staged STEMI Complete Revascularization: MULTISTARS-AMI https://www.medscape.com/viewarticle/995961
- MULTISTARS AMI trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823
- Complete Revascularization Now Compulsory? MULTISTARS-AMI and FIRE in Context https://www.medscape.com/viewarticle/995676
IV. Iron-Supplementation in Heart Failure
IV Iron Shows Only Modest Benefit in HF: HEART-FID https://www.medscape.com/viewarticle/995874
Sep 01 2023 This Week in Cardiology
Friday, September 1, 2023 • Duration 31:14
ESC Wrap-up 1: Obesity, heart failure with preserved EF and reduced EF, AF, frailty, evidence translation, and catheter ablation are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
Anticoagulation No Benefit in Presumed AF Detected by Cardiac Devices
https://www.medscape.com/viewarticle/995861
Aug 25 2023 This Week in Cardiology
Friday, August 25, 2023 • Duration 30:25
GLP-1 agonists in HFpEF, DOACs for subclinical AF, renal denervation, and the matter of remaining in the profession are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Obesity and HFpEF
GLP-1 Agonists in HFpEF With Obesity: Are We There Yet? https://www.medscape.com/viewarticle/993980
Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844
- Semaglutide in Obese Patients With HFpEF https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
- Rationale/Protocol Paper https://doi.org/10.1016/j.jchf.2023.05.010
AHA 2025: Mandrola's Four Trials to Look Forhttps://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
DANCAVAS II https://doi.org/10.1093/eurheartj/ehaf704
DANCAVAS I https://www.nejm.org/doi/full/10.1056/NEJMoa2208681
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
- EHJ meta-analysis of Iron Supplementation https://doi.org/10.1093/eurheartj/ehad586
V. AF Prevention with Pacing
Minimizing Atrial Pacing No Benefit in Sinus Node Disease: DANPACE II https://www.medscape.com/viewarticle/996076
- DANPACE II https://doi.org/10.1093/eurheartj/ehad564
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine. https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
How Much AF Warrants Anticoagulation? NOAH-AFNET 6 Provides Clues
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Features
Mandrola's 5 Things to Look for at the Upcoming ESC 2023
https://www.medscape.com/viewarticle/995614
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact: news@medscape.net
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