As Andy Burnham is confirmed as the Labour candidate for the Makerfield by-election, George Parker asks whether this signals the start of a long goodbye for Sir Keir Starmer as Prime Minister. He brings together Labour MP, Miatta Fahnbulleh, who resigned as an Energy minister earlier this month, and Jonathan Ashworth, formerly a member of Keir Starmer's Shadow Cabinet.

The question of whether Britain should one day rejoin the EU has reared up once again in this shadow Labour leadership contest. To discuss that George speaks to the EU's former ambassador to the UK, Joao Vale de Almeida.

Following the Government's confirmation that HS2 could eventually cost over £100bn and may not open until 2039, George turns to Labour MP Ruth Cadbury, who chairs the Transport Select Committee, and Sir Geoffrey Clifton-Brown, the Conservative chairman of the Public Accounts Committee.

And, is Kemi Badenoch doing a good job as Conservative leader? George speaks to Lee Cain, former Number Ten Director of Communications to Boris Johnson, and Times columnist, Seb Payne.

Pippa Crerar discusses the political reaction to the murder of 18-year-old student Henry Nowak, following the release of police bodycam footage. She is joined by Labour peer and human rights campaigner Shami Chakrabarti and Reform UK MP Richard Tice, who is also the party's deputy leader.

To discuss the battle of ideas and leadership sparked by former Labour prime minister Tony Blair's recent essay, Pippa is joined by Stewart Wood, Labour peer and former adviser to Gordon Brown, and the Conservative peer David Willetts, who is president of think tank the Resolution Foundation.

This week, the new Archbishop of Canterbury, Dame Sarah Mullally, led her first debate in the House of Lords on the impact of artificial intelligence on human relationships and society. To discuss this, Pippa is joined by the Lord Bishop of Leicester, Martyn Snow, and crossbench peer Beeban Kidron, who both took part in the debate.

This year marks the centenary of the 1926 general strike. Pippa discusses the impact and legacy of the strike with Labour peer and former general secretary of the Trades Union Congress, John Monks, and journalist and author Anne Perkins, who wrote a book about the strike, A Very British Strike.

Following the bombshell resignation of John Healey as Defence Secretary, Ben speaks to Sir Michael Fallon, a former Conservative Defence Secretary, and Luke Charters, a Labour MP who has campaigned on defence finance issues.

After the horrific knife attack in Belfast on Monday, and the street violence that followed, Ben brings together the former First Minister of Northern Ireland, Baroness Foster, and the Labour Chair of the Northern Ireland Select Committee, Tonia Antoniazzi.

Could next week's by-election in Makerfield precipitate a change of Prime Minister? And, if so, how tricky is it to change a leader in the middle of a parliament? Ben hears from Professor Philip Cowley of Queen Mary University of London and Cleo Watson, a former senior aide to Boris Johnson.

And, as the World Cup gets underway, Ben talks football and politics with two superfans, former Scottish Conservative leader, Ruth Davidson, and comedian and political interviewer, Matt Forde.

Vicki Young assesses Andy Burnham's Makerfield by-election win, which paves the way for a leadership challenge against Sir Keir Starmer.

She is joined by FT political editor, George Parker; New Statesman political editor, Ailbhe Rae; GB News political editor Christopher Hope and Labour peer and broadcaster Ayesha Hazarika.