Explore every episode of the podcast The Rounds Table

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1)https://mountpleasantgroup.permavita.com/site/DrMichaelPaulFigueroaFralick.html

2)https://deptmedicine.utoronto.ca/news/memoriam-dr-michael-paul-figueroa-fralick

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Welcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent trial looking at metformin for knee osteoarthritis in patients with overweight or obesity. Here we go!

1. Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity:
   A Randomized Clinical Trial (0:00 – 8:19).

The Good Stuff (8:20 – 9:13):

• Diabetes Trial Files (https://diabetestrialfiles.substack.com/) 
• Trial Files (https://trialfiles.substack.com/)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of a Mediterranean diet, compared with traditional dietary advice, on irritable bowel syndrome (IBS). Here we go!

1. The Mediterranean Diet for Irritable Bowel Syndrome: A Randomized Clinical Trial (0:00 – 4:50).

The Good Stuff (4:51 – 5:57):

• 3Blue1Brown's Neural Network educational video series: Check out the playlist on YouTube

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of caffeinated coffee consumption compared with abstinence from coffee and caffeine on recurrent atrial fibrillation (AF). Here we go!

1. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation:
   The DECAF Randomized Clinical Trial (0:00 – 4:32).

The Good Stuff (4:33 – 5:29):

• Moss in space! (https://www.cbc.ca/news/science/space-moss-9.6984791)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Happy New Year, Rounds Table Listeners! In this throwback episode (initial release 29 May 2025), Dr. Mike Fralick and special guest Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, sit down to chat about the top drug interactions you might be missing. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In our year-end episode, Drs. Mike and John Fralick discuss five important research studies published in 2025:

1. Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO) (0:00 – 4:20)
2. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (SUMMIT) (4:21 – 9:30)
3. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) (9:31 – 15:03)
4. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) (15:04 – 18:09)
5. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE) (18:10 – 23:49)

The Good Stuff (23:50 – 25:27):

• Toronto Star Santa Claus Fund, Calgary Food Bank, The War Amps 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent meta-analysis examining beta-blockers after myocardial infarction in patients with an ejection fraction of at least 50% and no other indications for beta-blocker therapy. Here we go!

1. Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction (0:00 – 8:54).

The Good Stuff (8:55 – 9:43):

• NPR Music Tiny Desk Concerts

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent trial examining whether noninvasive blood-pressure monitoring is noninferior to early insertion of an arterial catheter in patients with shock admitted to the ICU. Here we go!

1.  Deferring Arterial Catheterization in Critically Ill Patients with Shock (0:00 – 11:05).

The Good Stuff (11:06 – 11:59):

• We've launched Critical Care Trial Files! https://criticalcaretrialfiles.substack.com/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial comparing rituximab with conventional strategy for the induction of remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Here we go!

1. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis: A Randomized Controlled Trial (0:00 – 5:40).

The Good Stuff (5:41 – 6:31):

• The I'm Pharmacy podcast, now featured on Medicine Pods: https://medicinepods.com/im-pharmacy/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! This week, Dr. Mike Fralick welcomes returning guest Dr. Yatin Chadha, radiologist at North York General Hospital and founder of the beyond MD podcast, to chat about Dr. Chadha's recently launched online course series beyond Radiology. Here we go!

Check out Dr. Chadha's course series beyond Radiology:

• CT Head Basics for Clinicians - Ruling out Neurosurgical Emergencies
• CT Head Basics - Artifact or Pathology?

Learn more about Dr. Chadha and his work:

• https://www.beyondmd.ca/
• https://www.linkedin.com/in/yatin-chadha/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent systematic review and meta-analysis that looks at continuing versus withholding RAS inhibitors before noncardiac surgery. Here we go!

1. Evaluating the risks and benefits of continuing versus withholding renin–angiotensin system inhibitors: a systematic review and meta-analysis with trial sequential analysis (0:00 – 8:20).

The Good Stuff (8:21 – 9:44):

• NotebookLM

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of spironolactone on heart failure and cardiovascular death in patients undergoing maintenance dialysis, and antibiotic prophylaxis in patients with cirrhosis and upper gastrointestinal bleeding. Two papers, here we go!

1. Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial (0:00 – 7:19)
2. Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis (7:20 – 15:08)

And for the Good Stuff (15:09 – 17:51):

• The $500m slugger who helped Canada get to the World Series
• Clinical practice guidelines one-pagers coming soon to Trial Files: https://trialfiles.substack.com/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this throwback episode (initial release 14 Mar 2024), Dr. Mike Fralick and special guest, Dr. Laiya Carayannopoulos from the Intern at Work Podcast, discuss two papers: one exploring the role of non-invasive ventilation in comatose patients after acute poisoning, and and one on the use of the PEN-FAST Score in the point-of-care risk assessment of penicillin allergy. Two papers, here we go!

1. Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning (0:00 – 16:25).
2. Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy (16:26 – 24:17).

And for the Good Stuff:

• Celebrating Research Success! (24:18 – 25:14).
• Non-inferiority results: everything you need know in 5 minutes! and Is Noninferior Not Inferior? (25:15 – 26:48).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent trial examining whether amiloride is noninferior to spironolactone in reducing systolic blood pressure in patients with resistant hypertension. Here we go!

1. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial (0:00 – 8:10).

Run-in studies:

• Application and impact of run-in studies
• Application and Impact of Run-In Studies for the Evaluation of Statin Efficacy and Safety

The Good Stuff (8:11 - 9:14):

• Trial Files: https://trialfiles.substack.com/
• Heme Onc Trial Files: https://hemeonctrialfiles.substack.com/
• Allergy & Immunology Trial Files: https://allergyimmtrialfiles.substack.com/
• Critical Care Trial Files: https://criticalcaretrialfiles.substack.com/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent phase 2 trial looking at the effects of once-weekly semaglutide on alcohol consumption and craving in adults with alcohol use disorder (AUD). Here we go!

1. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder (0:00 – 10:28).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! This week, Dr. Mike Fralick sits down with Mihir Pandya, a third-year medical student at Western University. Mihir picks Mike’s brain for advice on preparing for internal medicine clerkship: What’s the best approach to acquire knowledge on the varying conditions seen in internal medicine? How can you foster better rapport with patients? What’s the best way to ask your staff physician for a reference letter? Answers to these questions and more—here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining fecal microbiota transplantation (FMT) in primary C. difficile infection. Here we go!

1. Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection: A Randomized Controlled Trial (0:00 – 4:47).

The Good Stuff (4:48 – 5:36):

• The I'm Pharmacy podcast, now featured on https://medicinepods.com/im-pharmacy/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial looking at aspirin in patients with chronic coronary syndrome receiving oral anticoagulation. Here we go!

1. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (0:00 – 9:43).

Throwback to EPIC-CAD: 

• The Rounds Table Episode 94: Top Papers from the 2024 European Society of Cardiology Congress 

The Good Stuff:

• Trial Files is a free monthly newsletter on practice-changing trials, delivered straight to your inbox (https://trialfiles.substack.com/).
• Guidelines summaries coming to Trial Files soon!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Drs. Mike and John Fralick discuss some of the top papers from the 2025 European Society of Cardiology (ESC) Congress. Hot off the presses, here we go!

1. Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias (0:00 - 5:23)
2. Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction (5:24 - 10:23)
3. RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults (10:24 - 16:09)
4. Apixaban for Extended Treatment of Provoked Venous Thromboembolism (16:10 - 20:55)

The Good Stuff (20:56 - 22:53):

• Thrombo Trial Files (https://thrombotrialfiles.substack.com/)
• John Candy: I Like Me at the Toronto International Film Festival 
• The I'm Pharmacy podcast is now live on www.medicinepods.com 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! This week, Dr. Mike Fralick sits down with Dr. Mina Tadrous, a pharmacist, researcher, Assistant Professor at the University of Toronto's Leslie Dan Faculty of Pharmacy, and host of the I'm Pharmacy podcast. If you're curious about what it takes to run a podcast, musings on the future of AI and drug discovery, and whether Mike can hold his own in a 90's-style rap battle, this is a conversation you don't want to miss. Here we go!

Check out the I'm Pharmacy podcast (new season begins 17 Sep 2025), now on https://medicinepods.com/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a throwback trial of dexamethasone in adults with acute bacterial meningitis. Here we go!

1. Dexamethasone in Adults with Bacterial Meningitis (0:00 – 11:19).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the effects of mifepristone on glycemic control in adults with inadequately controlled type 2 diabetes and hypercortisolism. Here we go!

1. Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment (0:00 – 10:24).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of infrequent zoledronate administration on vertebral fracture prevention in early postmenopausal women, and the efficacy and safety of semaglutide in adults with type 1 diabetes and obesity. Two papers, here we go!

1. Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age (0:00 – 10:24)
2. Semaglutide in Adults with Type 1 Diabetes and Obesity (10:25 – 17:48)

And for the Good Stuff (17:49 – 19:46):

• Canadian tennis player Victoria Mboko wins the Canadian Open!
• The I'm Pharmacy podcast— coming soon to www.medicinepods.com.

Thank you to our sponsor, FIGS scrubs. Rounds Table listeners can save 20% on their next purchase with code FIGSCA at https://www.wearfigs.com/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of perioperative hypotension-avoidance versus hypertension-avoidance
strategies on delirium and 1-year cognitive decline after noncardiac surgery, and the effect of as-needed albuterol–budesonide on risk of severe asthma exacerbation among patients with moderate-to-severe asthma. Two papers, here we go!

1. Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery (0:00 – 11:25)
2. As-Needed Albuterol–Budesonide in Mild Asthma (11:26 – 21:12)

And for the Good Stuff (21:13 – 23:17):

• Shout out to all the emergency medicine physicians!
• If you are interested in checking out the alpha version of the chatbot for One-Pagers for the Wards, reach out to Mike at fralickmpf@gmail.com.

Thank you to our sponsor, FIGS scrubs. Rounds Table listeners can save 20% on their next purchase with code FIGSCA at https://www.wearfigs.com/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of bedtime vs morning administration of antihypertensive medications on major cardiovascular events and death. Here we go!

1. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial (0:00 – 5:18).

The Good Stuff:

• Resources for trainees (5:19 - 6:20):
  • Medicine Pods: https://medicinepods.com/
  • Life in the Fast Lane: https://litfl.com/ecg-library/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2024:

1. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (FINEARTS-HF) (0:00 – 4:09)
2. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) (4:10 – 9:28)
3. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW) (9:29 – 14:23)
4. Tirzepatide for Metabolic-Dysfunction Associated Steatohepatitis with Liver Fibrosis (SYNERGY-NASH) (14:24 – 20:28)
5. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (BALANCE) (20:29 – 23:59)

And for the Good Stuff:

• Toronto Star Santa Claus Fund, Calgary Food Bank, Epilepsy Canada (24:00 - 25:23)

Calling keen trainees!

• Trainees, med students, residents: The Rounds Table and Trial Files (https://trialfiles.substack.com/) are looking for keen individuals to support our efforts.
• Reach out to fralickmpf@gmail.com if you are interested in getting involved. 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the simultaneous initiation of SGLT2 inhibitors and finerenone (a nonsteroidal mineralocorticoid receptor antagonist) in persons with chronic kidney disease and type 2 diabetes. Here we go!

1. Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (0:00 – 9:28).

Calling keen trainees! (9:29 - 10:28)

• Trainees, med students, residents: The Rounds Table and Trial Files are looking for keen individuals to support our efforts.
• Trial Files is a free monthly newsletter on practice-changing trials, delivered straight to your inbox (https://trialfiles.substack.com/).
• Reach out to fralickmpf@gmail.com if you are interested in getting involved. 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. Karim Ladak—rheumatologist and internist, Clinical Assistant Professor at McMaster University, and host of the Rheumatology for the Royal College podcast—to talk about leukocytoclastic vasculitis. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial exploring the effects of add-on sotatercept in patients with advanced pulmonary arterial hypertension and a high risk of death. Here we go!

1. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death (0:00 – 5:38).

The Good Stuff:

• 2025 Scripps National Spelling Bee winning word: éclaircissement (5:39 - 6:34)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Dr. Mike Fralick and guest host Danielle Cutler discuss the top papers from the 2025 American Diabetes Association (ADA) Scientific Session. Hot off the presses, here we go!

1. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial (0:00 - 6:05)
2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (6:06 - 13:22)
3. Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes (13:23 - 20:35)

The Good Stuff:

• Diabetes Trial Files - Free monthly newsletter! Subscribe at https://diabetestrialfiles.substack.com/ (20:36 - 21:00)
• Congrats to Danielle and all the med students finishing their academic year! (21:01 - 21:57)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have the next episode in our Clinical Practice Guidelines series. Drs. Mike and John Fralick discuss the top takeaways from the 2024 KDIGO Clinical Practice Guidelines for chronic kidney disease. Here we go!

1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (0:00 - 24:24)

Access the KDIGO 2024 "Top 10 Takeaways" PDFs here: https://kdigo.org/guidelines/ckd-evaluation-and-management/

The Good Stuff:

• Nephrology Trial Files - https://nephrotrialfiles.substack.com/ (24:25 - 24:48)
• The Phoenician Scheme (24:49 - 25:33)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have another special episode— Trial Files turns two years old this June, and we're celebrating with an episode summarizing the Top 5 RCTs in the Trial Files catalogue to date. Dr. Mike Fralick takes us through five trials in 15 minutes. Here we go!

1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (0:00 - 3:08)

2. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (3:09 - 5:37)

3. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis (5:38 - 8:33)

4. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (8:34 - 11:22)

5. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (11:23 - 13:23)

Happy 2nd Birthday, Trial Files!

• A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up at https://trialfiles.substack.com/ (13:24 - 14:19)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Trial Files series, where we provide an overview of a recent Trial Files issue. This week, Dr. Mike Fralick discusses three trials included in a recent throwback issue: opioids versus non-opioids for chronic pain; IV albumin for renal impairment and mortality; and omeprazole before endoscopy in patients with GI bleed. Three trials, 9 minutes, here we go!

1. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Trial (00:00 - 2:46)

2. Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis (2:47 - 4:50)

3. Omeprazole before Endoscopy in Patients with Gastrointestinal Bleeding (4:51 - 7:39)

What is Trial Files?

• A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up here! (7:40 - 8:40)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go!

1. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07).

The Good Stuff:

• Trial Files, a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:08 - 7:53)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, to chat about the top drug interactions you might be missing. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back, Rounds Table Listeners! This week we have a solo episode with Dr. John Fralick, discussing a recently published trial of the GLP-1 receptor agonist semaglutide for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Here we go!

1. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (0:00 – 6:33).

The Good Stuff:

• Go Leafs go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the safety and efficacy of lorundrostat (an aldosterone synthase inhibitor) in treatment of uncontrolled and treatment-resistant hypertension. Here we go!

1. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension (0:00 – 7:02).

The Good Stuff:

• Trial Files, a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:03 - 7:50)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast. This week, Dr. Mike Fralick and special guest Dr. Laiya Carayannopoulos from the Intern at Work Podcast and our Medicine Pods collaboration discuss two recent papers: the use of brensocatib (a DPP-1 inhibitor) to treat bronchiectasis, and the effect of alteplase administered 4.5 to 24 hours after stroke in patients with mild posterior circulation stroke who did not receive thrombectomy. Two papers, here we go!

1. Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis (0:00 – 12:46)
2. Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours (12:47 – 24:55)

And for the Good Stuff (24:56 – 26:08):

• Medicine Pods 
• qMonthly newsletter 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Clinical Practice Guidelines series. This week, Drs. Mike and John Fralick discuss the 2025 ACC/AHA Clinical Practice Guidelines for Acute Coronary Syndrome. Here we go!

1. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes (0:00 - 18:56)

Mike's interview with Dr. Jeff Carson:

• Episode 110 - Restrictive versus Liberal Transfusion in Myocardial Infarction with Dr. Jeff Carson

The Good Stuff:

• Egg cracking tips! (18:57 - 19:47)
• Jerro (19:48 - 20:47)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of tirzepatide in weight reduction and diabetes prevention in persons with obesity. Here we go!

1. Tirzepatide for Obesity Treatment and Diabetes Prevention (0:00 – 10:24).

The Good Stuff:

• We've launched qMonthly, a monthly blog highlighting headliners and hidden gem trials published each month. Check it out here! (10:25 - 11:23)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining liberal fluid intake vs. fluid restriction in chronic heart failure. Here we go!

1. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (0:00 – 4:20).

And for the Good Stuff:

• starpowerdrummer on YouTube (4:21 – 5:20).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of high-dose Vitamin D therapy in reducing disease activity in patients with clinically isolated syndrome (CIS) typical of multiple sclerosis (MS). Here we go!

1. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Trial (0:00 – 7:35).

Announcements (7:36 – 9:15):

• Canadian physicians, 2025 CMPA Council elections are underway in Alberta and Ontario! View the candidates and cast your ballot here.
• Check out Dr. Yatin Chada's podcast, beyondMD!

And we've launched qMonthly, a monthly blog highlighting headliners and hidden gem trials published each month. Check it out here!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss top papers from the 2025  American College of Cardiology (ACC) Annual Scientific Session. Hot off the presses, here we go!

1. Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism (0:00 - 5:55)
2. Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation (DapaTAVI) (5:56 - 9:51)
3. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes (9:52 - 14:04)
4. Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE) (14:05 - 18:36)

The Good Stuff:

• The Studio TV series on Apple (18:37 - 19:11)
• Cardiology Trial Files (19:12 - 20:40)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Dr. John Fralick and guest host Dr. Chunpeng Nie discuss two recent papers: resmetirom for the treatment of Nonalcoholic Steatohepatitis (NASH)—now known as Metabolic Dysfunction-Associated Steatohepatitis (MASH)—with liver fibrosis, and the effect of a Mediterranean diet on disease activity, inflammation, and the gut microbiome in patients with ulcerative colitis. Two papers, here we go!

1. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis (0:00 – 10:17)
2. A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial (10:18– 15:45)

And for the Good Stuff:

• Shoutout to all the MTU teams supporting their R1's! (15:46 – 16:20).
• For the 1st time in Canada, surgeons put teeth in patients' eyes to restore sight (16:21 – 17:56)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2023:

1. Hydrocortisone in Severe Community-Acquired Pneumonia (0:00 – 5:39).
2. Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes (5:40 – 8:48).
3. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (8:49 – 12:29).
4. Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection (12:30 – 17:49).
5. Early versus Later Anticoagulation for Stroke with Atrial Fibrillation (17:50 – 23:38).

And for the Good Stuff:

• The Beckham docuseries on Netflix (23:39 – 24:15)
• Upside Drinks (24:16 – 26:04).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners!

We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Jeffrey Carson, Distinguished Professor of Medicine at the Rutgers Robert Wood Johnson Medical School and Provost at Rutgers University, to chat about his recent publication - Restrictive versus Liberal Transfusion in Myocardial Infarction — A Patient-Level Meta-Analysis. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss two recent papers examining the effect of glucagon-like peptide-1 receptor agonists (GLP1's) on patients living with Parkinson’s disease. Two papers, here we go!

1. Trial of Lixisenatide in Early Parkinson's Disease (0:00 – 10:24).
2. Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease (10:25 – 17:40).

And for the Good Stuff:

• Port Blandford artist creates portraits from Scotch tape (17:41 – 18:33).
• Rheumatology for the Royal College podcast (18:34 – 19:42).

This episode is sponsored by Northern Ontario Resident Streamlined Training and Reimbursement Program (NORSTAR). Check out details here!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he will discuss a paper exploring endovascular treatment (EVT) for acute ischemic stroke due to medium-vessel occlusion. Here we go!

• Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion (0:00 – 6:02).

This episode is sponsored by Northern Ontario Resident Streamlined Training and Reimbursement Program (NORSTAR). Check out details here!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners!

We are back today with our Classic Rapid Fire Podcast!

This week, Drs. Mike and John Fralick discuss two recent papers - the role of continuous glucose monitoring for diabetes management in hospital and the benefit of tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Two papers, here we go!

1. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (0:00 – 11:26).
2. DIATEC: A Randomized Controlled Trial (11:26 – 19:56).

And for the Good Stuff:

• Surgeons successfully transplant genetically edited pig kidney into U.S. man (19:56 – 20:55).
• Diabetes Trial Files (20:55 – 22:25)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners!

We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Amy Yu, a Stroke Neurologist, Clinician-Scientist, and Associate Professor of Medicine at the University of Toronto and Sunnybrook Hospital, to chat about her hot-off-the press publication - Population-Level Screening for Diabetes and Dyslipidemia After Pregnancies Complicated by Hypertension or Diabetes!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods