Orthotics and prosthetics are entering a new era. Instead of hand-built devices that take days to shape and adjust, clinicians can now scan a limb, tune the geometry in software, and print a device that fits with impressive consistency. This episode explores how that shift is happening in real clinics and fabrication labs by hearing from experts who are shaping the future of digital O and P.

We have Michael Schmitt of Prosthetic Plus , who has moved from traditional clinical practice into advanced additive manufacturing and now helps run a central fabrication site that blends MJF and FDM production. He explains how accurate scanning and thoughtful CAD design create devices that can be reprinted months later from the same file in a perfect new size. David Johnson of HP builds on this by showing how polymer Multi Jet Fusion has become a reliable platform for orthotics and prosthetics, offering durable materials, isotropic strength, and the throughput needed for large-scale production.

Once the prints come off the build plate, Emilie Simpson of DyeMansion
explains how they are transformed into smooth, hygienic, biocompatible devices through cleaning, surfacing, vapor smoothing, and deep-dye coloring. Her work shows why post-processing is essential for patient comfort and clinical durability. Finally, Tara Wright of Gillette Children’s Specialty Healthcare brings everything back to the patient. She shares a compelling case where her team scanned and printed a replacement UCBL that matched the feel of a worn original, cut fitting time dramatically, and performed well for more than fifteen months. Her experience demonstrates how digital production can raise consistency and reduce strain on clinicians.

Together, these voices map out a practical path for clinics that want to adopt scan-to-print workflows. Start with accessible FDM printers to learn digital modification. Move to production with MJF through central fabrication or service bureaus. Scale when your volume, staffing, and materials align, and explore decentralized scanning with centralized manufacturing to broaden access.

Whether you are a clinician, technician, engineer, or healthcare innovator, this conversation offers a clear look at how digital manufacturing is transforming O and P. Tune in to learn how these tools can deliver better fit, faster turnaround, and more equitable access for patients everywhere.

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In this episode, Dr. Karolina Valente, Founder and CEO of VoxCell BioInnovation, discusses her journey in biotechnology, focusing on 3D bioprinting and its impact on cancer research and drug discovery. She shares insights into her leadership at VoxCell, the company's growth, and the accolades it has received. Dr. Valente also talks about the importance of partnerships, the future of biotechnology, and her personal experiences that drive her passion for innovation.

Questions answered:

• How did Karolina first get involved with entrepreneurship and founding VoxCell BioInnovation?
• What was it like to start a career across multiple continents? (From Brazil to Canada)
• How to switch the hat from a scientist to a company founder?
• What were some of the early milestones in the VoxCell journey that were impactful to the company today?
• What is the core technology of the 3D bioprinting platform at VoxCell?
• How does VoxCell’s technology address the Vascular Challenge in cancer research?
• What kind of data do you provide in preclinical studies, and how does it compare to animal models?
• How does Karolina navigate and build company culture at VoxCell?
• What advice does Karolina have for young entrepreneurs and students in school?

See full show notes, links, and resources.

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The future of medicine is growing closer to recreating the very building blocks of life itself. In this groundbreaking discussion, four bioprinting experts reveal how their technologies are moving rapidly from laboratory concepts to clinical realities that could forever change how we treat disease.

Mike Graffeo, the CEO and co-founder of FluidForm Bio, shares the group's remarkable progress toward eliminating insulin injections for type 1 diabetes patients. Their FRESH 3D bioprinting technology creates implants that produce insulin naturally in response to blood glucose. "Life should not come with a needle," Graffeo emphasizes, highlighting how their approach could deliver a functional cure. 

Other leaders in bioprinting go on to share their unqiue approaches to 3D innovation in medicine. Annaliese Vojnich, Business Development and Technical Sales Manager at ViscoTec America, demonstrates how Puredyne's progressive cavity pump technology achieves precise extrusion while maintaining cell viability.

 Dr. Jorge Madrid-Wolff, Application Scientist, reveals Readily3D's volumetric printing, which creates complex structures in seconds rather than hours, enabling functional mammary gland models that produce milk proteins and beating cardiac tissue. Dr. Karolina Valente, Founder and CEO, explains how VoxCell BioInnovation's vascularized tissue models are addressing the 95% failure rate of oncology drugs in clinical trials by providing more translatable data than animal testing.

Ready to witness firsthand how bioprinting is transforming from science fiction into medical reality? This discussion provides both the scientific foundations and practical pathways that will bring these revolutionary technologies from laboratory benches to hospital bedsides within the next decade.

Sound Engineer: Faith Fernandes

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What happens when cutting-edge technology meets veterinary expertise? Precision, innovation, and better outcomes for our four-legged family members. 

Dr. Bill Oxley, a prominent figure in veterinary orthopaedics, walks us through the evolving world of 3D-guided veterinary surgery. With years of surgical experience behind him, Dr. Oxley began to question the limits of traditional planning methods. Complex bone deformities that looked manageable on initially often became challenges in the operating room. The tools weren’t the problem. The planning was. His solution? Bringing veterinary orthopedics into the three-dimensional world through advanced imaging, computer-aided design, and 3D printing.

Dr. Oxley's approach helped 3D planning completely change how we asses deformities for the better. The shift from struggling with conventional 2D planning to creating precise surgical guides. These custom guides allow surgeons to make exactly the right cuts in exactly the right places, dramatically improving outcomes for patients with complex orthopedic conditions. The emotional highlight comes when he shares the story of a Great Dane with bone cancer who, thanks to this technology, went from facing amputation to running joyfully on the beach just weeks after reconstructive surgery.

Beyond the technical aspects, we explore the business challenges of building Vet3D, the global adoption of these techniques, and how pet insurance dramatically impacts which animals can access these life-changing procedures. For pet owners, this conversation offers invaluable insights into what's possible when your beloved companion faces orthopedic challenges.

Curious about the cutting edge of veterinary care? Want to understand how technology is expanding what's possible for our pets? This episode will leave you amazed at how far veterinary medicine has come and hopeful about where it's heading. Connect with Dr. Bill directly at bill@vet3d.co.uk to learn more about these groundbreaking approaches.

Show notes, photo gallery, resource links: Please see our show notes here.

Sound Engineer: Faith Fernandes 

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This is an AI-generated audio version of the news section of the Lattice Newsletter. You can find the full newsletter, including a list of recent healthcare 3D printing and bioprinting news here. 

Full Lattice Newsletter Archive.

Highlighted news this week:

• US Army developing field-deployable bioprinting labs for creating custom skin grafts in combat zones
• Stanford researchers designing organ-scale vascular trees for 3D-printed hearts 200 times faster than previous methods
• First patient treated with a bioengineered external liver (ELAP) for acute liver failure
• Researchers creating 3D bioprinted brain models that mimic real neural networks for studying Alzheimer's
• FDA-cleared monolithic full-color 3D printed dentures (Trudent) revolutionizing dental prosthetics
• New polymer blend for 3D printed medical devices kills 99.99999% of common bacteria
• World's first 3D-printed femur transplant in an 8-year-old child in Vietnam
• Healthcare systems bringing 3D printing capabilities directly into hospitals for point-of-care manufacturing
• Six key trends: hyper-personalization, point-of-care manufacturing, advanced materials, increased efficiency, addressing healthcare challenges, and regulatory progress

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Artificial intelligence is transforming medical 3D printing and bioprinting. In this virtual event, hear from a panel of experts from across the globe. Our speakers showcase the practical applications of AI in creating personalized medical solutions that were previously impossible.

One size does not fit all. William Jung, Business Development Director of FITme in South Korea, explains how AI-driven customized silicone implants are revolutionizing cosmetic and reconstructive surgery. Using a design screening engine that reduces design time from hours to minutes, FITme’s technology has supported over 30,000 surgical cases and captured 85% of the Korean market.

At the National University of Singapore, Dr. Gopu Sriram explores dental applications of 3D bioprinting. He discusses how an AI-optimized bioprinting process allow for the biofabrication of personalized gum tissue constructs. Gum disease is a worldwide public health burden that affects almost half adults over age thirty. This solution not only addresses these patients, but dramatically accelerates experimental timelines.

Dr. Gregory Hayes brings in the business perspective and shares how EOS Additive Minds is implementing AI across multiple fronts to democratize access to additive manufacturing. Their systems incorporate advanced monitoring tools capable of making real-time adjustments during printing. This allows medical professionals to stay focused on patient outcomes over technical issues.

Focusing on women's health, Aye Nyein San from Cosm Medical shared how their AI-powered digital gynecologic devices are giving women their lives back, with patients describing their products as "magical" and "life-changing."

What makes this event so compelling to listen to is how our speakers illustrate AI’s ability to break down long-standing barriers to 3D printing adoption. By automating complex design decisions and enhancing process reliability, AI is turning specialized, expertise-heavy workflows into scalable, patient-centered solutions.

Ready to explore how AI and 3D printing could effect your medical practice or research? Subscribe to our podcast for more insights into this rapidly evolving field, and join our community of innovators.

Shownotes: https://3dheals.com/event-recap-artificial-intelligence-updates-for-3d-printing-and-bioprinting/

Podcast Engineer: Faith Fernandes

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Printhead technology may not sound revolutionary, but what if it could radically transform the way we manufacture everything from electric motors to medical implants? That's exactly what Ben Harkoff and his team at Quantica have achieved with their breakthrough inkjet system that can handle materials 10-20 times more viscous than any conventional technology.

Starting in 2018 with a simple goal of printing electronics, Ben's team became frustrated when every existing printhead failed spectacularly when trying to eject viscous resins. Their solution? Design something completely new using piezo crystal actuators and compliant mechanisms that could amplify deformation. This innovation unlocked the ability to print materials with viscosities ranging from 250 millipascal-seconds at operating temperatures to 15,000 millipascal-seconds at room temperature, opening up vast new possibilities for manufacturing.

What's particularly fascinating is Quantica's journey from 3D printing visionaries to practical problem-solvers. As Ben candidly shares, the company discovered its most immediate impact wasn't in creating complete 3D-printed products but in revolutionizing existing manufacturing processes. Their technology now enables precision deposition of adhesives for e-motors, replacing inefficient dispensing methods and potentially improving motor efficiency. They've validated the printing of true platinum-catalyzed silicone (SYLGARD 184) without additives—a breakthrough for medical applications—and are exploring how viscoelastic materials enhance cell viability for bioprinting applications.

Whether you're interested in manufacturing technology, materials science, or how startups navigate the challenging path from invention to commercial success, this conversation offers valuable insights. Ben's advice for aspiring inventors? "Become obsessed and become an expert in research... train your attention span... and learn about politics, because part of the job is not only the technical depth but also dealing with people." Listen now to discover how printing the unprintable is creating entirely new possibilities across industries.

Complete show notes with references

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Tuan Tranpham shares his extraordinary journey from Vietnamese refugee to 3D printing industry leader, offering unique insights on industry evolution, technological innovation, and future trends. His global perspective bridges Eastern and Western manufacturing approaches while highlighting continuous carbon fiber printing opportunities and microfactory development.

• Vietnamese refugee turned global 3D printing leader
• 3D printing in 2003, after Z Corp 
• The Journey: 3D Systems, Desktop Metal, Anisoprint
• Industry consolidation and integration strategies
• Carbon fiber 3D printing for aerospace and defense
• Highlights China’s rapid rise in 3D printing innovation
• AI, robotics, and AM will enable portable microfactories
• Built a personal brand on LinkedIn
• Innovation is key to staying competitive
• Bravery and generosity in career growth

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When EOS president Glynn Fletcher declared "3D printing is cool, but cool is not a business model" at Rapid TCT 2025, he captured the evolution across the additive manufacturing landscape. In this eye-opening conversation with Craig Rosenblum, president of Himed, we explore how the industry matures beyond technological demonstrations toward practical, sustainable applications.

Craig brings a unique perspective as both a materials science expert and the leader of a 35-year-old biomaterials company (Himed) that has adapted to incorporate 3D printing into its portfolio. He walks us through the shifts he observed at North America's largest 3D printing conference, where the atmosphere has noticeably changed from previous years' technology showcases to focused discussions on industry-specific solutions.

The conversation reveals fascinating developments, from the MIT startup creating "gravity-defying" materials through Rapid Liquid Printing in hydrogels to the reality behind AI buzzwords in additive manufacturing. We discuss how the ecosystem surrounding 3D printing is expanding, with increased participation from supporting industries like materials suppliers and testing laboratories, who recognize their crucial role in advancing the technology.

Perhaps most compelling is the emphasis on collaboration over competition. As Stratasys CEO Yoav Zeif noted, "The competition is status quo" - a recognition that advancing additive manufacturing requires collective effort across sectors rather than siloed approaches. This collaborative mindset particularly resonates in healthcare applications, where improved patient outcomes provide a powerful shared purpose.

Whether you're a 3D printing professional, healthcare innovator, or curious about how manufacturing is evolving, this conversation offers valuable insights into an industry at an inflection point - moving from what's possible to what's useful, from technological spectacle to sustainable transformation.

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Peering into the microscopic world of fluid channels just got a revolutionary upgrade. At this 3DHEALS event, we explore the transformative impact of 3D printing on microfluidic device development with industry experts and researchers at the cutting edge of this technology convergence. Our speakers share how specialized 3D printing systems are overcoming traditional fabrication limitations, enabling rapid prototyping and the creation of revolutionary new designs. 

Summary: 

• Hamdeep Patel from CatWorks3D discusses a specialized 3D printing system optimized for microfluidics with unbeatable feature resolution.
• CatWorks3D’s CytoClear material achieves 90% cell viability with optical transparency for direct microscopic analysis.s
• Paul Marshall from RapidFluidics provides rapid microfluidic prototyping services for researchers and companies worldwide.
• Professor Christopher Moraes from McGill University utilizes 3D-printed parts combined with biocompatible materials for advanced organoid culture applications.
• Jeff Schultz from Phase AM is developing technology to directly 3D print PDMS (Silgard 184) without modifications.
• Key adoption factors include leveraging 3D printing's unique capabilities rather than replicating 2D designs.
• The integration of world-to-chip interfaces, such as Luer locks, significantly improves device reliability.
• Creating truly 3D structures with complex internal geometries represents the future of microfluidics.

The consensus is clear: successful adoption requires leveraging 3D printing's unique capabilities rather than simply replicating 2D designs. As these technologies mature, we are witnessing the emergence of truly three-dimensional microfluidic systems with integrated functionality that promises to revolutionize diagnostics, drug development, and biological research.

SUBSCRIBE to join us at future 3DHEALS conferences to connect with innovators and investors in the rapidly evolving field of 3D printing for healthcare applications.

Watch this event recording on demand.

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Podcast engineer: Faith Fernandes

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Sam Onukuri takes us through his remarkable 30-year journey at Johnson & Johnson, where he transformed the landscape of medical devices through pioneering work in 3D printing technology. As a material scientist who led the development of J&J's Center of Excellence for additive manufacturing, Sam offers rare insights into how a global healthcare giant approached innovation and personalized medicine.

The conversation reveals the fascinating evolution of medical 3D printing from basic prototyping to FDA-approved implants. Sam shares the story behind breakthrough products, such as the TrueMatch graft cage – a PCL-based, bioabsorbable scaffold for bone reconstruction that has dramatically improved patient outcomes. His candid assessment of where personalization succeeds (craniomaxillofacial implants) and where it falls short (knee replacements) provides a nuanced perspective rarely found in technology discussions.

We examine the unexpected challenges that have shaped the industry, including the complex regulatory landscape, the emergence of surgical robots, and the economic realities that have tempered some early expectations. Sam's firsthand experience with point-of-care printing initiatives and customized surgical instruments provides valuable lessons about striking a balance between innovation and practicality in healthcare settings.

Looking toward the future, Sam identifies promising frontiers, including bioprinting, advancements in materials science, and the integration of AI with 3D printing technologies. For students and professionals considering careers in this field, he emphasizes the importance of strong engineering fundamentals and experiencing both startup and corporate environments to develop a comprehensive skill set.

Whether you're a healthcare professional, engineer, investor, or simply curious about how medical innovation occurs, this conversation offers an authentic glimpse into the triumphs, setbacks, and unrealized dreams that continue to shape the future of personalized medicine and additive manufacturing.

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3DHEALS kicked off its first in-person/hybrid event in 2025 in San Francisco, welcoming investors, entrepreneurs, and innovators in the space. The healthcare industry is transforming, driven by 3D printing and bioprinting technologies redefining patient care. This exclusive in-person hybrid event offered an opportunity to explore the latest advancements in custom prosthetics, implants, bioprinted tissues, and scaffolds.  The remarkable convergence of 3D printing and healthcare transforms medicine through customized solutions that weren't possible a decade ago. This episode brings together five leaders in the healthcare field who are harnessing additive manufacturing to solve real clinical problems and improve patient outcomes.

Summary:

• 3D-printed spinal implants have evolved from simple titanium cages to sophisticated expandable devices that restore alignment and relieve nerve compression
• Patient-specific radiation shields protect healthy tissue during cancer treatment, reducing devastating side effects like oral mucositis
• Bioprinted organoids are creating human-derived testing platforms for drug discovery
• 3D-printed trabecular metal structures are providing better bone integration for joint replacements
• AR/VR integration with 3D printing is a robust tool for surgical planning, training, and patient education..
• Evidence-based innovation remains critical, focusing on validated clinical problems rather than technology for technology's sake.
• The shift toward ambulatory surgical centers drives demand for minimally invasive solutions that 3D printing can uniquely deliver.
• Investment in medical 3D printing continues as clinical applications expand.

The experts emphasize that successful innovation must be evidence-based, addressing validated clinical problems rather than pursuing complexity for its own sake. The speakers agreed, "Just because it's complex doesn't mean it's better." This wisdom encapsulates the mindful approach needed as we continue exploring the vast potential of 3D printing in healthcare.

SUBSCRIBE to join us at future 3DHEALS conferences to connect with innovators and investors in the rapidly evolving field of 3D printing for healthcare applications.

Watch this event recording on demand.

Check out our blog for an in-depth analysis of the event!

Youtube Event Highlight Playlist.

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Summary

In this conversation, Jenny Chen explores the complex implications of ChatGPT on intelligence and education. She emphasizes the need for careful consideration of the technology's impact, particularly in academic settings, and discusses the broader context of a technological revolution that may have both positive and negative consequences.


Takeaways

• Is ChatGPT making us dumb?
• This is a much more complicated question.
• ChatGPT is problematic, especially for students.
• We should consider this carefully and thoughtfully.
• We're at a juncture of technological revolution.
• Revolutions typically will have some casualties.
• How can we use this new tool effectively?
• Maximize our productivity without diminishing humanity.
• Not causing something unthinkable, like being ruled by AI.
• The good and evil of this very potent tool.

Show Notes: 

https://3dheals.com/is-chatgtp-or-ai-making-us-stupid-two-cents/

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 Jenny and Matthew discussed the latest trends and innovations in the orthopedic and medical device industry, including regenerative medicine approaches for joint and spine conditions, new technologies like 3D printing and wireless endoscopes, and workflow management solutions to improve hospital efficiency after Matthew's recent blog about his AAOS 2025 experiences. They highlighted exciting startups like Genix, Osteal Therapeutics, and Ospitek that are disrupting traditional treatment paradigms. Matthew also shared his insights on the changing landscape of industry conferences and the potential impact of politics and regulation on medical innovation. Overall, the conversation covered a wide range of cutting-edge developments that could significantly improve patient outcomes and transform the future of orthopedics.

Introductions and background

Jenny and Matthew introduce themselves and provide background on their respective roles and businesses. 

Trends at recent industry conferences

Matthew shares his observations from attending recent industry conferences like the Canaccord Genuity and AAOS events. He notes trends around decreasing surgeon attendance at the larger conferences, and increased interest in regenerative medicine and solutions for prosthetic joint infections (PJI).

Regenerative medicine innovations

Matthew highlights two promising regenerative medicine companies - DiscGenics, Osteal Therapeutics, which has an implantable pain relief solution. He discusses the potential for these innovations to disrupt traditional spine surgery

Advancements in surgical tools and workflow

Matthew discusses new technologies like wireless endoscopes from companies like Lazurite and single-use endoscopes from Pristine Surgical that are improving surgical visualization and sterility. He also highlights Ospitek, a company using real-time patient tracking to optimize hospital workflow and efficiency.

Potential impact of political changes

Matthew shares his perspective on how the new Trump administration may impact medical device companies.

Recap and future outlook

Jenny and Matthew conclude by discussing the dynamic and evolving nature of the medtech industry, and the importance of remaining optimistic about the potential for innovation to improve patient outcomes, despite political and economic uncertainties.

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Learn how 3D printing technology is revolutionizing veterinary medicine with applications from orthopedic correction guides to custom-made titanium implants for cancer patients.

• 3D printing allows unprecedented precision in complex veterinary surgeries
• Orthopedic surgical guides can correct deformities within two degrees of accuracy
• Custom implants enable limb-sparing procedures for bone cancer patients
• Neurosurgical applications make pedicle screw placement safer for spinal fixation
• Maxillofacial reconstruction with 3D printed implants offers solutions for trauma and cancer cases
• Manufacturing standards remain a concern as veterinary implants lack human-grade regulations
• Technology has evolved from simple models to complex guide systems in less than a decade
• Educational models with bone-like properties are enhancing surgical training
• Proper CT imaging techniques are crucial for successful 3D model creation
• Collaboration between surgeons and engineers produces the best outcomes

Join us on this journey through cutting-edge veterinary medicine and see how this technology could benefit your practice or pet.

Full video recording is now available at 3DHEALS.COM/Courses

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We examine the pivotal role of 3D printing technology in reshaping orthopedic implants and enhancing patient outcomes in this virtual event. This discussion navigates the crossroads of innovation and caregiving in modern medicine by featuring expert insights from industry leaders. 

• Focus on patient-specific implants and their clinical implications 
• Discussion on biocompatible materials and new technologies 
• Regulatory landscape for 3D-printed orthopedic devices 
• Insights on surgical practices and patient recovery trends 
• The benefits of personalization in surgical interventions 
• Investigations into osseointegration and design efficacy 
• Evolving market dynamics and future trends in 3D printing 

Listen to this virtual event recording, a thought-provoking exploration of 3D printing's revolution in healthcare and the impact of innovation in the orthopedic space!

Full on-demand recording: https://3dheals.com/courses/3d-printed-devices-in-orthopedics/

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Discover FRESH 3D bioprinting with Mike Graffio, CEO and co-founder of Fluoform3D. Having met at Carnegie Mellon University, Mike and Adam Feinberg have been on a mission to revolutionize the field of bioprinting, focusing on creating replacement tissues and organs without introducing foreign substances into the body. Mike shares the captivating journey from their engineering days in the 1990s through a pivotal 2015 conversation that transformed their research into a thriving startup and onto achieving significant milestones like developing living cardiac tissues and heart valves by 2018.

Our conversation uncovers the next frontier in 3D bioprinting, particularly the promising strides in islet cell replacement therapy for diabetes. You'll hear about how the FRESH bioprinitng propels this innovative field forward. With breakthroughs in small animal models showing potential for diabetes management, we explore how the team is gearing up for more extensive studies and human clinical trials. This episode also delves into their strategic fundraising efforts and partnerships to bring these advancements to life.

Summary:

• Overview of Fluoform3D and its founding story 
• Explanation of FRESH Technology and its significance in bioprinting 
• Current progress in cardiac applications and in vitro tissues 
• Ongoing projects related to therapeutic applications  for type I diabetes
• Insights into navigating funding and building investor relationships 
• Discussion on regulatory pathways and interactions with the FDA 
• Emphasis on company culture and team dynamics 
• Recommendations for industry insights and staying informed about bioprinting trends

Show Notes:

Instagram interview with Mike in 2021
Fluidform3D website
Breakthrough publication in 2019 made it to the cover of Science magazine-"FRESH 3D Printing Used to Rebuild Functional Components of the Human Heart"
YouTube Video: https://youtu.be/BJbReV0v7Co

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Our panel of investors at the 3DHEALS Pitch3D Demo Day 2025 provide 3D printing startups and entrepreneurs advice and opportunities as they start their journey in MedTech.

Nicole Black, PhD (https://www.linkedin.com/in/nicole-black-phd/) is the Program Director for MedTech Innovator, a nonprofit supporting early-stage and mid-stage medical device and diagnostics startups.

Peter Mercelis (https://www.linkedin.com/in/peter-mercelis-1624358/) is a medical device and 3D printing entrepreneur who has been active in 3D printing industry since 2003.

Dr. Jesse Courtier (https://www.linkedin.com/in/jesse-courtiermd/) is Chief of Pediatric Radiology at UCSF Benioff Children’s -San Francisco, Founder of Sira Medical, a venture backed UCSF spinout in the Augmented Reality space, and serves as an advisor to a number of accelerators and VC firms including KidsX and Avon River Ventures.

Full recordings are now on Youtube channel:

Pitch3D Playlist

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#medical3dprinting #medtech #bioimpression #surgicalplanning #ARVR #3DTechnology #anatomicalmodels #implants #digitalhealth #healthcare #biotech #bioprinting #bioprinter #tissueengineering #regenerativemedicine #biomedical #bioartificial #bioengineering  #pharma #dental3dprinting #dentallaboratory #digitaldentistry #dentistry #digitaldentures

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This just dropped! #podcast This past Saturday, I had a pleasant visit from Dr. Mohit Chhaya, CEO and co-founder of BellaSeno, a startup in Leipzig, Germany, working on #3Dprintedimplants for soft tissues and bone. We had some nice green tea and pastries and chatted about many things from his worldly experiences of residing in four countries and #GameofThrones, as well as the joy of reading. However, more importantly, we chatted about his company, technologies, vision and ambition, and a little military strategy and history. Enjoy!

Written interview here
Book suggestion: Alexander the Great and the Logistics of the Macedonian Army
Reconstruction of an Extensive Segmental Radial Shaft Bone Defect by Vascularized 3D-Printed Graft Cage

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A lot of us started our journey in healthcare 3D printing accidentally. Listen to this ice-breaker style interview with Dr. Shafkat Anwar, Pediatric Cardiology Director of Cardiac MRI, as well as Co-Founder and Co-Director of the UCSF Center for Advanced 3D+ Technologies (CA3D+). Hear his story on how 3D+ Technologies beyond 3D printing is helping patients (and their families) fighting against congenital heart disease and how UCSF 3D+ Lab is combating against the ongoing pandemic. His full written interview can be found here.   He will be speaking at "Point of Care" panel at the upcoming 3DHEALS2020 in June, 2020.


Dr. Shafkat Anwar (Twitter: @ShafkatAnwar) is a pediatric cardiologist with a specialty in non-invasive cardiac imaging, including echocardiography and cardiac magnetic resonance imaging (MRI). 

He is the Pediatric Cardiology Director of Cardiac MRI, as well as Co-Founder and Co-Director of the UCSF Center for Advanced 3D+ Technologies (CA3D+). He is a founding member and the inaugural Chair of the Advanced 3D+ Visualization Special Interest Group in the Society for Cardiovascular Magnetic Resonance. He is a consultant at Printerprezz, a medical start-up in Fremont, CA utilizing additive and other advanced manufacturing technologies to develop the next generation of medical devices.  At Printerprezz. Dr. Anwar serves as the Senior Vice President of Medical Innovations. Dr. Anwar completed his internship and residency in Pediatrics at Children’s National Medical Center, as well as a research fellowship at the National Institutes of Health. He completed fellowships in Pediatric Cardiology and Cardiac Imaging at Cleveland Clinic and Children’s Hospital of Philadelphia. Prior to joining UCSF, Dr. Anwar was the Cardiology Director of Cardiac MRI at Washington University in St. Louis, St. Louis Children’s Hospital.  At Wash. U. Dr. Anwar co-founded and co-directed the Center for 3D Printing, a multi-disciplinary 3D printing center. He will be speaking at "Point of Care" panel at the upcoming 3DHEALS2020 in June, 2020.

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How well do we really understand the body? For decades, surgeons have relied on static scans and flat 2D models to plan procedures. Gilly Yildirim believes it’s time to expand our view to more dimensions. As founder and CEO of Vent Creativity, he is bringing together point clouds, digital twins, and physics-based AI to capture movement with a level of precision that static imaging is far from.

In conversation with Jenny Chen, Gilly Yildirim describes how his team built a platform that sees the body not as a collection of bones, but as a dynamic system of forces and interactions. Their software models the physics of ligaments, cartilage, and bone to predict how a patient’s knee will behave before surgery even begins. The goal is to give surgeons a more clear and reliable picture of what they’re working with.

Yildirim shares the thinking that shaped his company’s approach. The team’s goal wasn’t to design a product, but to build a service that integrates into real clinical practice. Vent’s technology includes Minerva, an adaptive AI engine trained on real anatomical data. It powers Hermes, an FDA-cleared knee planning tool, and inVENT, a cloud platform that lets surgeons explore patient-specific digital twins in full 3D.

Gilly Yildirim has 20 years of experience in orthopedics, so he has unique understanding of the clinical and technical sides of surgical innovation. He discusses how biomechanics, imaging physics, and computational modeling converge within Vent’s framework to create accurate, reproducible results. The same methods used to map a knee could soon extend to hips, shoulders, cardiac systems, and even to full-body digital twins that integrate data across multiple organs and modalities. His work points toward a future where medical planning is not based on snapshots, but on simulations that mirror the patient’s unique physiology.

This episode offers a deep, imaginative look at how AI, physics, and human creativity are coming together to build the next generation of surgical intelligence.

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Microfluidics has long promised to reshape diagnostics, drug discovery, and laboratory science. Microfluidics is about manipulating how tiny amounts of liquid move through channels no wider than a human hair; a "lab on a chip" diagnostic. Now imagine being able to 3D print those channels instead of painstakingly etching them. Paul Marshall, CEO of Rapid Fluidics, is working to improve the norm by applying additive manufacturing to the design and production of microfluidic systems.

In this episode, Jenny Chen speaks with Marshall about how 3D printing enables fluidic devices with architectures that cannot be produced through conventional techniques. Traditional fabrication locks researchers into rigid patterns and flat geometries. Paul's work extends beyond basic microfluidics. 

His team creates remarkably detailed anatomical models by converting medical imaging data into functional vascular systems that mimic human biology. These models provide alternatives to animal testing and training platforms for medical procedures. They've also worked on embedding electronics directly into microfluidic devices, creating "smart" systems that can measure biological changes in real-time. Their work clearly demonstrates the potential of infusing engineering precision with scientific imagination.

Paul Marshall reflects on the growth of his career as a founder by detailing the progression from experimental prototypes to a growing enterprise serving research communities. Marshall launched this venture at the beginning of the COVID-19 pandemic, a seemingly unpromising time to start a business. However, as diagnostic companies pivoted to develop coronavirus tests, the demand for rapid prototyping exploded. Now five years later, Rapid Fluidics serves global healthcare giants from their base in Newcastle, England, while planning expansion to the United States. 

This conversation offers a perspective on microfluidics that goes beyond the traditional. If you’ve ever wondered how big breakthroughs emerge from small scales, this episode makes the case that the tiniest channels can carry some of the most exciting ideas.

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What truly makes bioprinting possible isn’t just 3D printers. It's important to understand the materials that flow through them. In this virtual event, we explored the world of biomaterials for tissue engineering and how chemists are shaping the future of regenerative medicine through careful material design. 

On demand course: https://3dheals.com/courses/advanced-biomaterials-for-3d-printed-medtech-and-biotech/

YouTube highlights: Here

Our editorial event recap: https://3dheals.com/what-are-the-latest-advances-in-biomaterials-for-3d-bioprinting/

Bowman Bagley, Vice President of Commercial at CollPlant, introduces recombinant human collagen made from genetically modified tobacco plants. This approach avoids animal-derived components while improving performance. The collagen can be concentrated to higher levels and modified more effectively than traditional sources, producing structures that support tissue regeneration while staying printable.

Dr. Janaina Dernowsek, Co-Founder and CEO, takes us inside the Quantis Biotechnology platform, where her team has developed a way to create human extracellular matrix (ECM) from bioprinted tissue constructs. By using dermal-like tissues as bioreactors, they harvest complex protein networks that promote cell growth without triggering inflammation, opening new possibilities for skin regeneration and beyond.

Dr. Riccardo Levato, highlights volumetric bioprinting, a method that uses patterned light to form entire structures within seconds. His team combines material chemistry with advanced design techniques, allowing printers to respond to cellular environments in real time and build vascular networks that support tissue function.

 Dr. Jasper Van Hoorick, Co-Founder and CEO of BIO INX, addresses the need for standardization and confronts "biofabrication deception". He describes how his company creates consistent, high-performing materials tailored to specific printing technologies. This work helps make bioprinting more reliable and accessible for researchers worldwide.

Finally, Dr. Scott Taylor, CTO at Poly-Med, discusses absorbable synthetic polymers that provide mechanical support during tissue regeneration and then safely degrade once their job is done.

Whether you are a researcher, clinician, or industry professional, this episode highlights how material science is driving progress in bioprinting and bringing new possibilities to tissue engineering.

Podcast Engineer: Faith Fernandes

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What happens when advanced mathematics meets manufacturing? The result is a new way of creating products that range from record-breaking running shoes to life-changing medical devices.

In this episode, we sit down with Elissa Ross, mathematician and CEO of Metafold 3D, to explore how her company is using mathematics to reshape design and manufacturing. Metafold’s platform is built on geometric intelligence which is her company's novel approach that transforms shapes into data that can be analyzed and improved. Instead of simply representing objects the way traditional CAD software does this method allows engineers to simulate and optimize designs with greater speed and accuracy.

At the core of this approach is implicit modeling with signed distance functions. While it may sound highly abstract, it has very practical applications. This technique allows manufacturers can run thousands of simulations in the time it would normally take to analyze a single design. The result is shorter development cycles and products that perform better in the real world.

Ross also reflects on her journey building Metafold, from its early focus on 3D printing to its current role serving major industries. She explains how their API-first platform gives customers the flexibility to solve specific challenges, such as analyzing tolerances, reusing similar parts, or predicting how designs will hold up under different conditions.

Whether you are a designer, an engineer, or simply curious about how mathematics is shaping the technologies around us, this episode offers a thoughtful look at the future of manufacturing intelligence.

Shownotes: Check back soon

Podcast Engineer: Faith Fernandes

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Cartilage injuries sideline millions every year, yet current treatments often fail to restore long-term function. In this episode, Dr. Nathan Castro and Dr. Ben Holmes, co-founders of Nanochon, explain how they are tackling this challenge with a 3D-printed implant designed not only to replace damaged tissue but to help it regrow. What began as a collaboration in a graduate lab has grown into a company now preparing for its first human clinical trial.

Their journey began at George Washington University in Dr. Grace Zhong’s tissue engineering lab, where the freedom to explore outside of strict grant-funded projects encouraged bold experimentation. Nathan even purchased specialized materials with his own money to expedite early tests. That investment in curiosity became the foundation for a technology that could change how orthopedic surgeons treat cartilage damage.

Nanochon’s implant blends strength with biology. It pairs a smooth articular surface with a porous lattice that integrates directly with surrounding tissue. Traditional approaches, Nathan explains, can be “like filling a pothole with jelly.” By contrast, their device provides stability without the need for sutures or pins. Despite being less than half the thickness of conventional implants, it requires two to three times more force to dislodge, which may result in shorter recovery times for patients.

From there, the company advanced step by step. They began with small animal studies in rats, progressed to goats, and finally proved the implant’s strength and integration in horses. These results not only built regulatory confidence but also convinced investors. With Health Canada’s approval for its first-in-human trial, Nanochon stands on the edge of translating a decade of persistence into clinical impact.

Ben and Nathan also reveal the realities of building a medical device startup, including raising funds during tight markets, meeting ISO 13485 quality standards, and learning to manage external contractors. This conversation is a rare look behind the curtain of medtech entrepreneurship. It shows how innovation happens in steady layers, built one on top of another, much like 3D printing itself.

Shownotes

Podcast Engineer: Faith Fernandes

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What if your medication could be made just for you? No more pill overload and no more awkward dosing workarounds. Just the exact treatment you need when you need it. That is the promise of 3D printed pharmaceuticals.

Drug manufacturing has relied on a one-size-fits-all model for decades. Nearly half of all medications lack proper formulations for children and seniors are often left struggling to manage boxes of pills each day. It is time for a smarter, more personal approach.

In this episode, you will hear how innovators around the world are reimagining what medicine can be. Dr. Alvaro Goyanes, CEO and Co-Founder of FABRX, explains how his team launched the world’s first clinical application of 3D printed drugs in 2018, paving the way for personalized dosing. From Singapore, Dr. Seng Han Lim, Co-Founder and COO of Craft Health, describes how their heat-free printing technology protects fragile biologics that traditional methods destroy. And in Finland, Dr. Niklas Sandler, Founder and CTO of CurifyLabs, shows how they are bringing 3D printing directly into pharmacies with compact printers and cartridge systems, giving pharmacists the ability to produce safe, customized medicines on demand. To ensure these advances are reliable and widely adopted, Dr. Thomas Forbes of the NIST shares how the institute is building essential measurement standards for printed pharmaceuticals.

From shrinking the pill burden for tuberculosis patients to tailoring cancer treatments for individuals, the breakthroughs are already here. The possibilities are just as striking looking ahead. Just think of on-demand medicines in disaster zones, or astronauts printing personalized therapies on long space missions.

This conversation offers a front-row seat to the future of medicine, whether you are a healthcare professional, technologist, or patient advocate. Tune in as we explore how 3D printing is not only changing the way drugs are made, but also redefining what medicine can mean.

Watch on demand: https://3dheals.com/courses/3d-printed-pharmaceuticals/

Event highlight shownotes

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Lee Dockstader takes us on a fascinating journey through the commercialization of 3D printing in healthcare, drawing from his decades of experience with industry giants like HP and 3D Systems. Dockstader is one of the major pioneers of the 3D printing revolution that helped transform medical applications today.

The conversation takes us behind the curtain of industry-defining moments few people know about. One is the story of Invisalign. Today it’s a household name, but in its early years Align Technology struggled to survive. Orthodontists resisted the innovation, and for nearly a decade the company failed to turn a profit. It was only when dentists began to embrace the technology that it found its footing. We explore why some healthcare segments adopt 3D printing rapidly while others move at glacial pace, and the fascinating business dynamics that determine success beyond just having superior technology.

Dockstader then goes on to give his account of the hearing aid industry's rapid transformation. Unlike dental's decades-long evolution, hearing aid manufacturing converted entirely to 3D printing within just five years in the early 2000s. The perfect storm of new scanning technology, specialized resins, and advanced printers led to dramatic improvements: reducing remake rates from 20% to 5% and transforming a craft that took a year to master into a skill learnable in days. With five companies controlling 80% of the market, once one adopted the technology, competitors had no choice but follow.

Looking toward the future, Dockstader shares his surprise that 3D printed eyewear hasn't yet achieved mainstream adoption despite its obvious benefits. With conventional frames offering limited sizing options despite high tooling costs, 3D printing could provide perfectly fitted frames for diverse facial structures at competitive prices. 

As he looks back on his career, Lee Dockstader leaves listeners with a clear message. Persistence pays off, and finding the right champions within an industry can be the key to turning groundbreaking ideas into world-changing realities.

Stay tuned for show notes with relevant links and resources.

Sound Engineer: Faith Fernandes 

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Imagine holding a child’s heart in your hands and seeing the exact path a surgeon must take before a single incision. That shift from uncertainty to clarity frames this conversation on how 3D printing, virtual reality, and advanced imaging are transforming pediatric cardiology. Our speakers show how AI-assisted segmentation, multimodality fusion, VR rehearsal, and rapid mixed-reality planning are reshaping preoperative strategy and improving communication with families.

Sarah Ptashnik of Materialise opens with the modeling perspective, walking through how CT, MRI, echo, and cath-lab 3DRA are turned into precise hollow heart models that guide baffles, conduits, and catheter routes. Nicholas Jacobson of Tangible Vet Tech brings the design and device lens, sharing how voxel modeling, hemocompatible printing, and cross-species research accelerate innovation for complex repairs. Dr. Ravi Ashwath of Baylor College of Medicine and Christus Children’s Hospital explains how advanced MRI, CT, and VR planning shorten procedure time and help teams anticipate complications in demanding congenital cases. Dr. Shafkat Anwar of UCSF Benioff Children’s Hospitals expands on fusion imaging and mixed reality for high-risk interventions, while Dr. Jenny Zablah of Children’s Hospital Colorado highlights how 3D tools improve strategy for pulmonary vein stenosis and other complex anatomies.

Together, they explore real cases in which 3D models reshaped surgical plans, revealed hazards that imaging alone missed, and enabled bench-testing of devices before entering the cath lab. The discussion covers sterilizable materials, device libraries, accuracy checks, and how VR and AR support rapid decision-making when there is no time to print.

If you are building or refining a 3D program, you will find practical guidance on quality control, when to print versus stay digital, and how to scale these tools across a health system. 3D technologies are becoming the standard for safer, smarter, and more human cardiac care.

See show notes and video highlights

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In this episode, Alyssa Huffman, CEO and co-founder of Allumin8, shares the six-year journey behind a first-of-its-kind 5.5 mm porous, 3D-printed pedicle screw. We discussed how Allumin8 earned FDA clearance and why design details matter for fatigue, fixation, and fewer revisions. We also map a path toward therapeutic hardware that integrates orthobiologics without slowing surgeons down.

Critical questions addressed:

Why does 5.5 mm matter so much?

How does Gaussian topography support bone ingrowth?
What are some of the lessons from fatigue testing and post-processing?
What are the additive vs milled manufacturing trade-offs?
What was Allumin8's FDA journey and strategy?
When and how do orthobiologics add value?
How did Alyssa build a purpose-aligned team and investor base?
What are some practical founder advice on equity and boards?
What is on Alyssa's wishlist for the future of orthopedic implants? 

Please listen to the disclaimer at the end of this podcast.

Stay tuned for our show notes for relevant links, video highlights, glossary of terms, and more resources to enjoy this episode. 

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We map the biggest shifts in healthcare 3D printing this month, from emissions safety to custom eyewear, implant surfaces, microfluidics, and space-based biomanufacturing. We weigh promise against risk and share where standards and design can close the gap.

• emissions from desktop and industrial printers and why they matter 
• safeguards for vulnerable groups and safer materials and testing 
• face-scan eyewear, on-demand manufacturing, and fashion collaborations 
• implant surface roughness, porosity, coatings, and clinical outcomes 
• ceramic, titanium, and PEEK devices for spine, ankle, and CMF 
• microfluidics for diagnostics and microneedle vaccines and immunotherapy 
• digital microfluidics and 3D cell culture for faster R&D 
• microgravity biomanufacturing and what space enables for medicine

See blog post related to this podcast: https://3dheals.com/the-lattice-feb-2026-advanced-devices-custom-eyewear-and-hidden-health-risks-of-3d-printing/

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We share how a decade of soft robotics, open APIs, and relentless iteration turned a 3D-printed prototype into a durable, touch-sensing bionic hand used by amputees and robots. Stories of failure, funding, and firsts reveal how speed, sensation, and design choices translate to real lives and real factories.

• early 3D printing wins and durability limits
• shift to soft robotics, silicone overmolding, carbon fiber reinforcement
• founding spark, Ecuador trial, and move from academia to company
• SBIR lifeline, failed crowdfunding, then coverage and clinical validation
• speed, grip force, and touch sensors compared with the market
• open API for control and data streaming in minutes
• robotics crossover in automotive and research labs
• access initiatives via the Ability Fund and global impact
• manufacturing scale plans and ethical boundaries
• practical founder habits, grit, and advice to start now

Please listen to the disclaimer at the end of this podcast

Show notes: https://3dheals.com/aadeel-akhtar-bionic-hands-for-humans-and-robots-the-psyonic-story/

YouTube: https://youtu.be/mDVMRhjXr0w?si=qoZrScjaC6nbiPMJ

About our guest:

Dr. Aadeel Akhtar, CEO of PSYONIC, founded the company to create advanced, accessible bionic limbs after meeting a young girl in Pakistan who was missing a limb. PSYONIC's bionic Ability Hand is the fastest on the market, impact-resistant, and the first to provide a sense of touch. It is also covered by Medicare and is being used by humans and robotics companies globally, including NASA, Meta, Mercedes, and Google. Dr. Akhtar earned a Ph.D. in Neuroscience and an M.S. in Electrical & Computer Engineering from the University of Illinois, along with a B.S. in Biology and an M.S. in Computer Science from Loyola University Chicago. He’s been recognized by MIT Technology Review and Newsweek and secured a 3-shark deal on Shark Tank. 

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We track a month of fast-moving news in healthcare 3D printing, from organ-scale bioprinting programs and ARPA-H’s funding model to point-of-care tools already entering clinics. The throughline is clear: vascularization, immune compatibility, and scale are converging with real-world deployment.

• UT Southwestern’s organoid-plus-bioprinting strategy for durable liver tissue
• Carnegie Mellon’s consortium on vascularization, immune control, and scale
• ARPA-H’s moonshot funding model is accelerating medical innovation
• Aspect Biosystems and Novo Nordisk’s bet on curing diabetes
• Cost shift from chronic management to curative therapies
• Near-term point-of-care printing: Curify Labs and AZORG integrations
• Key milestone to watch: functional vascular networks
• Outlook as research, industry, and funding align

Remember, this podcast is for educational and informational purposes only
The views expressed do not constitute engineering, medical, or financial advice. The technologies and procedures discussed may not be commercially available or suitable for every case. Always consult with a qualified professional

Shownotes: https://3dheals.com/lattice-news-arpa-h-organ-moonshots-point-of-care-manufacturing-and-more/

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A crowded JP Morgan week can blur into noise, so we built a quieter stage to focus on what actually moves healthcare forward: 3D software‑planned care, on‑demand manufacturing, and proof that patients and payers can feel. Recorded live in San Francisco, this special episode brings founders and investors together to show how 3D data and advanced manufacturing are turning personalization into a scalable, measurable reality.

We start with a rare blueprint for value in spine surgery: virtual planning, patient‑specific 3D printed implants, and post‑op analytics that cut two‑year reoperations by 74% while compressing lead times from eight weeks to eight days. From there, the conversation widens fast. Hear how microarray patches with five‑micron precision enable co‑delivery without co‑formulation and factory‑level scale; how therapeutic hardware draws on bone biology to reduce revisions; how personalized pessaries bring dental‑style business models to women’s health; and how drill‑free, patient‑specific dental implants fit in six days without a single turn of a drill.

We also explore the frontier where human recovery meets robotics. A single bionic hand platform serves amputees and humanoid robots, translating human manipulation data into industrial automation while staying Medicare‑covered. On the R&D side, vascularized tissues and cryobioprinted models aim to fix translational failure by making complex biology reproducible and shippable. Structural biopolymer fibers unlock sutures, meshes, and sports medicine implants with clean‑room scale. A countertop system automates cell therapy final formulation so community hospitals can treat more patients safely. And a new biomanufacturing approach targets IVIG supply constraints by achieving human‑like B‑cell densities in ultrafast 3D printed bioreactors. We close with high‑viscosity inkjet that prints materials traditional jets can’t, powering durable dental parts and microneedle patches at true production speeds.

Along the way, an investor panel compares notes on 2026: where exits might return, where non‑dilutive capital is shifting, and what it now takes to earn a check—clear end‑user value, defensible tech, and a distribution edge. If you care about medtech, bioprinting, cell and gene therapy delivery, or the future of personalized care, this is your field guide to what’s working right now.

If this conversation sparks new ideas or a partnership you want to pursue, subscribe, share the episode with a colleague, and leave a quick review telling us which breakthrough you want to hear more about.

Event speaker biographies: https://3dheals.com/life-in-3d-investing-in-the-next-frontier/

On-Demand Video (Pending publication): https://3dheals.com/courses/

Pitch 3D Application link: https://3dheals.com/pitch3d/

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Healthcare 3D printing is moving fast, and design is leading the way. In this episode, we explore how advanced CAD, simulation, and automation are enabling patient-specific implants, multi-material tissue-like structures, AI-powered prosthetics, and fully custom pediatric seating. Beyond the printer, human-centered design and smart workflows are turning ideas into devices that improve patient care. 

We start with the biology. Orthopedic engineer Matthew Shomper of Not a Robot Engineering, LatticeRobot, and Allumin8 explains why stress shielding sets up decades of problems and shows how patient-specific scaffolds can be generated in minutes. Analyze intact versus defect states, compare strain fields, and synthesize a topology- and strain-matched lattice tuned to a person’s real loading. Swap patterns, change valency, target grafting, and even plan for resorbable polymers as bone fills in. It is a shift from “stronger” to “more biologically honest.”

Then we open the toolbox. With volumetric and implicit design approaches explored by Rob MacCurdy at the University of Colorado Boulder’s Matter Assembly Computation Lab, design moves from surfaces to functions that define geometry, material, and behavior together. Think functional grading across a dogbone, gyroids blended between materials, or lattice struts whose composition varies along their length to steer buckling. The same logic can drive multiple printers and processes, enabling surgical models and tissue-like parts that span from soft to structural in a single build.

The payoff comes at the point of care. In prosthetics, comfort is the foundation. Joshua Steer, Founder and CEO of Radii Devices, shows how data-driven rectification gives clinicians an informed starting point they can refine. Nathan Shirley of HP explains how automation turns that interface into a robust, production-ready socket with a single request. No brittle CAD models. No days in design. And in pediatric seating, Alexander Geht of Testa-Seat shows how lightweight, water-cleanable, fully custom supports help children eat with family, attend school, and travel without a van full of gear.

Validation, reimbursement, and regulation still lag behind what is technically possible. But with open toolchains, integrated simulation, and outcomes data, patient-specific devices are moving from heroic one-offs to dependable care. Subscribe, share this with a clinician or engineer who should hear it, and tell us the one custom device you wish existed. What would you build next?

Video On Demand 

Event recap and video highlights: What are the latest design innovations in healthcare 3D printing?

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We explore how to move IVIG from donor scarcity to on‑demand manufacturing with tissue‑engineered bioreactors, and why that shift could lower costs, expand access, and improve consistency. We dig into polyclonal advantages, regulatory guardrails, scaling plans, and what success would mean for complex biologics beyond antibodies.

• Defining a bioreactor that recreates human tissue niches
• Why polyclonal IVIG remains essential across 100+ conditions
• Limits of donor‑dependent plasma supply and regional variability
• Complex therapeutics as a new manufacturing category
• Cost targets of 10–100x reduction and CapEx shrink
• Coffee‑cup reactors and near‑term validation milestones
• Quality metrics including pathogen panels and glycosylation
• Donor variability, blending strategies, and future immortalization
• Clinical impact of moving from rationing to earlier use
• Funding update and industry partnerships

Please listen to the disclaimer at the end of this podcast.

Show notes: https://3dheals.com/episode-102-can-bioprinting-bioreactor-reshape-the-future-of-immunology/

About our guests:

Dr. Melanie Matheu is an immunologist, inventor, and biotechnologist recognized for pioneering work in high-resolution tissue engineering and human immunology. She received her PhD in Physiology and Biophysics with a focus on Immunology from UC Irvine and completed postdoctoral training at VIB (Ghent University, Belgium) and UC San Francisco, where she specialized in 2-photon imaging and cellular immune responses. As founder of Prellis Biologics, Dr. Matheu brought forward laser-based tissue bioprinting to solve complex challenges in organ transplantation and therapeutic antibody discovery. She later co-founded Lyric Bio, where she serves as Chief Scientific Officer, advancing scalable biomanufacturing platforms and rapid human immune system modeling. Dr. Matheu has authored numerous peer-reviewed publications, holds multiple patents, and is a passionate advocate for innovation at the intersection of immunology and bioengineering.

Kevin Shannon (Kayj) holds a degree in Molecular Biology from Princeton University and a MBA from Stanford Graduate School of Business. Kayj has held positions spanning the biotech ecosystem including start-ups, big pharma, venture capital, and consulting. As part of Corporate Strategy at Amgen, he worked with Amgen’s C-Suite to shape long-term strategy, built partnerships in novel therapeutic modalities, and led investments in emerging categories including cell & gene therapy, antibody engineering, single cell analysis, and quantum computing. Kayj has also consulted for multiple VC funds where he developed investment theses and performed diligence in emerging technologies. Most recently, led business development for Zafrens, raising >$20M and securing two pharma company partnerships.

Kayj was first introduced to Melanie and the Prellis bioprinting technology when she brought him on as a consultant to evaluate initial applications for the company’s technology. Because of their strong working relationship and the remarkable nature of the technology, Kayj is excited to reunite with Melanie and join Lyric as CEO.

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What happens when a hospital needs a simple part but the supply chain takes weeks or months to deliver it? Dr. Stephan Ryan, physician and co-founder of PolyUnity, set out to solve that problem by helping hospitals produce parts themselves through safe, compliant 3D printing. In this episode, Stephen Ryan shares how early clinical experiences and an academic 3D printing lab evolved into a platform designed to help hospitals manufacture equipment on demand. The COVID pandemic accelerated that vision, exposing major supply chain gaps and pushing the team to rapidly scale production. Stephen Ryan explains how those lessons shaped PolyUnity’s approach to building practical additive manufacturing systems within the realities of healthcare procurement, regulation, and hospital workflows.

Bullet points:

• Defining PolyUnity’s mission to democratize hospital 3D printing with compliant workflows
• The rural hospital supply chain problem that sparked the original research project
• How COVID accelerated real-world production and forced end-to-end process design
• Why post-pandemic red tape returned and how it shaped the software moat
• Bootstrapping a medtech startup in Canada with long procurement cycles
• Building a small team and staying capital efficient through iterative deployment
• Good and "bad" ideas for hospital 3D printing applications
• High-ROI case applications that avoid big spend
• Distributed manufacturing hubs and the practical path toward on-site production
• The wisdom of choosing simple over complexity.
• Post-processing bottlenecks and what are potential solutions.
• Personal transformation from clinician to entrepreneur.
 
Show notes: https://3dheals.com/teleporting-medicine-with-3d-printing-dr-stephen-ryan-of-polyunity-interview/

Full video interview: https://youtu.be/cO7mTr5GLJ8?si=icmU03OI1cPDZJL9

About our guest: 

Dr. Stephen Ryan is a physician, entrepreneur, and the co-founder and Chief Medical Officer of PolyUnity, a Canadian health tech company focused on lowering the barrier for hospitals to adopt 3D printing through its i3D platform and solutions. His work centers on building software, quality systems, and distributed print capacity so that hospitals can reliably order and receive end use 3D printed parts, from simple fixtures to clinically relevant devices, within existing procurement and regulatory frameworks.

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What does it take to invent a technology that didn't exist before?

In this episode, host Dr. Jenny Chen sits down with Professor Paul Dalton, the inventor of melt electrowriting (MEW) and one of the rare "triple threats" in science: an inventor, educator, and futurist. This is also a conversation about science, creativity, and why MEW isn't just a technology but a movement.

Paul takes us from a boredom-filled childhood on a rural farm outside Perth, Australia, to the ophthalmic research lab where he helped build artificial corneas that restored sight to blind patients. He shares the moment a failing electrospinning experiment pushed him toward MEW instead — and the "breathless" discovery under the microscope that became MEW.

Along the way, Jenny and Paul explore:

• What electrospinning and melt electrowriting actually are, explained in plain language
• Why MEW pulls fibers instead of pushing them, and how it prints at one-tenth of a teardrop per hour
• The decades-long pursuit of clinical applications
• The open-source "MEWron" printer is bringing MEW to labs for a fraction of the cost of commercial machines
• The two kinds of makers — builders vs. users — and where the community is heading
• Paul's advice for clinicians and newcomers entering biofabrication

Plus, a remarkable offer for listeners at the end of this episode. 

🔗 Show notes

YouTube recording: Coming soon

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Surgery is moving into a world where we can measure, simulate, and even rehearse before we ever touch a patient, but getting 3D surgical planning to feel “normal” inside a hospital is still a battle. We bring together a rare mix of voices across the ecosystem to explain what’s actually working, what’s still missing, and what it takes to scale medical 3D printing and virtual surgical planning without sacrificing safety or quality.

Event Page: https://3dheals.com/3d-surgical-planning/

Subscribe, share this with someone building a 3D program, and leave a review with the biggest blocker you see to making 3D planning routine.

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This is our second episode recorded at the Materialise conference.  Our guest for this episode is no other than the CEO of Materialise Brigitte de Vet-Veithen. It is a pleasure for me to be able to conduct this interview, because Materialise is such a legendary company that has spent 35 years building the software and services infrastructure behind patient-specific implants, surgical planning, and point-of-care manufacturing. We also got to know Brigitte as a person and the new leader of the company. Importantly, we covered the metrics that signal adoption, challenges to scale beyond the halo case, and her vision for the industry.  In my opinion, this is perhaps one of the most important conversations for the medical 3D printing industry in 2026.

Highlights of this episode:

• Brigitte's journey from MedTech leadership to being the CEO at Materialise
• Why reimbursement is the clearest signal of adoption for medical 3D printing
• Building health economics evidence for patient-specific devices when every case is unique
• Helping physicians shift mindset toward pre-operative planning and new workflows
• The move from “3D printing company” to solution partner for specific clinical needs
• Why robots and surgical guides coexist, especially in ambulatory surgery centers
• How AI compresses lead times and expands access for trauma patients
• Mass personalization roadmap across orthopedics, CMF, pediatrics, respiratory, and structural heart
• Global adoption differences and why imaging availability sets the pace
• Investment priorities across education, evidence generation, R&D, and M&A

Please listen to the disclaimer at the end of this podcast.

Show Notes: https://3dheals.com/episode-114-interview-with-brigitte-de-vet-veithen-ceo-of-materialise/

YouTube: https://youtu.be/9PgME2RAmog?si=t-0X_DkrBdRg4MHe

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This is one of two episodes we have recorded during our trip to Leuven Belgium for the Materialise 2026 Conference, focusing on 3D planning and 3D printing in hospitals. We talked with Dr. Tristan Remcharan about how pediatric cardiology imaging can become something you can literally hold, using 3D segmentation and 3D printing to make congenital heart disease easier to plan, teach, and explain. We also dig into the 2D versus 3D generational divide and the real-world funding hurdles that decide whether point-of-care 3D becomes routine care. 

Show notes: https://3dheals.com/episode-113-how-3d-printing-explains-the-unexplainable-with-dr-tristan-ramcharan/

YouTube Video: https://youtu.be/eNUQWwJq5HM?si=3QhxXxvvUaEhO1MD

The 3D cardiac printing program at Birmingham Children's Hospital is funded by charitable donations. 

To support Tristan's works directly: Birmingham Children's Hospital Charity — https://www.bch.org.uk/appeal/donate

Donate to the 3D cardiac printing program

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You can learn a lot about the future of healthcare by watching how a single pill gets made. From a small office in London, we sit down with Prof Alvaro Goyanes, co-founder and CEO of FabRx, to unpack how 3D printed pharmaceuticals are turning personalized medicine from an idea into a working system. If you’ve ever wondered why patients still get forced into a handful of standard doses, this conversation shows what changes when medicine becomes software-driven and printable on demand. 

We talk about what FabRx is building, why they’ve stayed deeply research-led while pushing toward clinical application, and how partnerships with hospitals are translating 3D printing into real studies. We also get specific about the compounding pharmacy workflow: “pharma ink” syringes prepared ahead of time, doses selected in software, and tablets printed with controls that reduce manual steps and help cut inconsistency. It’s a practical look at personalized drug manufacturing for therapies that need flexible dosing across pediatrics, elderly care, hormones, and more. 

Quality is the backbone of everything here, so we dig into traceability, weighing each unit, pressure-sensing to catch extrusion problems early, camera systems that verify prints, and where AI inspection and near-infrared methods fit in. We zoom out to the policy layer, including the UK’s move toward distributed point-of-care manufacturing and how regulators in Europe and the US are beginning to shape guidance for 3D printing in pharmacies. Then we end on a wild but serious frontier: why NASA cares about printing medicines in space, where supply chains and gravity don’t cooperate. 

If you care about personalized medicine, 3D printing in healthcare, and the future of compounding pharmacies, hit subscribe, share this with a friend in pharma or medtech, and leave a review telling us what application you want to see next.

About Our Guest: 

Alvaro Goyanes is the co-founder and CEO of FABRX, the first company dedicated to developing 3D printing technology for the fabrication of personalized medicines and medical devices. He is also an Honorary Associate Professor at University College London- School of Pharmacy (UK) and an Associate Professor at the Faculty of Pharmacy, University of Santiago de Compostela (Spain).
A pioneer in the field, Alvaro was among the first researchers to explore the potential of 3D printing for manufacturing oral dosage forms and medical devices. Recognized as a world expert in 3D-printed medicines, he has been listed among the World's Most Highly Influential Researchers by Web of Science for six consecutive years since 2019.
Alvaro holds a PhD in Pharmaceutics from the University of Santiago de Compostela and previously worked as a Registered Pharmacist for three years, giving him firsthand insight into the needs of community pharmacy.

Show notes: Coming soon

YouTube: Coming soon

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A fun but insightful conversation during 3DHEALS2020 with two inspiring entrepreneurs in 3D Bioprinting space, Tamer Mohamed (CEO and co-founder of Aspect Biosystems), and Mike Graffeo (CEO and co-founder of Fluidform). Aspect bio has just successfully completed its series A round, and Fluidform just successfully raised its seed round. Learn from Tamer and Mike on what startup CEOs' challenges, experiences, visions, and advice for the biofabrication and 3D printing space.

Full conference video recording can be purchased here. 

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Have a complex spine problem? Mike Cordonnier from Carlsmed may have an answer for you. While orthopedic surgeons are no strangers to virtual pre-operative surgical planning, it is a different challenge to also provide a patient-specific implant to fit into the patient, rather than molding patient to fit the device. In this interview with our upcoming 3DHEALS2020 speaker, Mike and I discussed how his company aims to realize medical imaging to patient-specific surgical plan and device, leveraging AI, cloud computing, data, and additive manufacturing (or 3D printing). We also touched upon how the ongoing COVID19 pandemic will change the future of surgery. 

Mike Cordonnier is CEO and co-founder of Carlsmed, a San Diego based Med Tech company. Carlsmed’s Corra system utilizes predictive analytics to create patient-specific surgical plans and 3d printed implants to improve patient outcomes for spine surgery.  Mike has held various leadership roles for large MedTech companies NuVasive, Zimmer Biomet, and Orchid Orthopedics as well as early-stage startups Ellipse Technologies and X-Spine Systems.  Mike is passionate about leveraging technology to improve patient outcomes and decrease the cost of healthcare.  Mike has a B.S. in Mechanical Engineering from the University of Dayton. Mike will be a speaker for 3DHEALS2020 Orthopedic Panel.

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Neurotech is the category most investors whisper about and then walk away from: too technical, too regulated, too slow. We wanted to talk to someone who leans in anyway, so I sat down with Varun Turlapati, founder of Chanakya Capital, to hear how he’s building an early-stage fund dedicated to neurotech devices and why he thinks the “long horizon” objection often misses what’s actually happening on the ground.

We unpack Varun’s path from software engineering into venture capital, including the mindset shift from analysis paralysis to fast iteration with smart guardrails. From there, we widen the frame on what neurotech means. Yes, brain-computer interfaces matter, but we also get into neuromodulation, bioelectronics, and the nervous system as the body’s command network, linking the brain, gut, and heart, and addressing disease. That lens turns “niche” into “everyone with a brain,” and it changes how you think about markets, clinical impact, and investable product strategy.

Varun also shares the practical mechanics of deep tech investing: how he triages an 80+ company pipeline, separates “interesting” from “investable,” and brings in PhD scientists, physicians, and specialist advisors to evaluate clinical workflows and real differentiation. We dive into real examples across neuroprosthetics, Alzheimer’s, ADHD, and autism wearables, and a smart shunt for hydrocephalus, plus how regulatory signals like Breakthrough Device Designation can reshape the risk profile.

If you care about neurotech startups, medical devices, FDA pathways, or where venture capital goes after AI becomes commoditized, this conversation will sharpen your evaluation of both science and execution. Subscribe to Lattice, share this with a founder or investor who’s curious about neurotech, and leave a review with the biggest question you still have about building in this space.

Show notes: https://3dheals.com/episode-110-neurotech-investing-with-varun-turlapati-chaanakya-capital/

YouTube recording: coming soon

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Everyone talks about printing organs, but the closest thing to real impact often starts with something less flashy and far more practical: the materials. We bring together founders and operators working across bioprinted implants, structural bone substitutes, cryopreserved tissue models, and natural biopolymer manufacturing to answer one question that matters: what actually makes advanced biofabrication translate from bench to bedside?

We dig into bone regeneration and why scaffolds fail when they can’t balance strength, vascular support, and predictable resorption. You’ll hear how absorbable polyurethane platforms aim to avoid acidic degradation while letting teams program mechanics and timelines, plus how 3D printed beta-tricalcium phosphate ceramics can deliver structural consistency and then remodel into native bone. The conversation stays grounded in the realities that decide adoption: predicates and evidence expectations for FDA 510(k), the heavier burden of EU MDR, and the uncomfortable truth that clearance doesn’t guarantee reimbursement.

Then we shift to new approach methodologies for drug development, where cryobioprinting tackles the biggest blocker in bioprinted tissues: logistics. If tissues can be frozen, inventoried, shipped, and used on demand, bioprinting becomes a consumable workflow instead of an artisanal one-off. We close with a candid translation playbook for natural biopolymers and a high-volume pediatric use case: dissolvable chitosan ear tubes designed to reduce repeat surgeries, plus the pricing and coverage strategy needed to make that upgrade viable.

Subscribe, share this with a builder in medtech or biotech, and leave a review with your biggest takeaway: which bottleneck matters most right now, materials, regulation, reimbursement, or scale-up?

Event link: https://3dheals.com/bench-to-bedside-bioprinting-innovations/

YouTube highlights: Stay tuned

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We track the biggest healthcare 3D printing stories from March 2026, from bioprinted organs and sustainable bioinks to FDA-cleared implants and hospital point-of-care wins. We also look at how 3D printed cancer tools, training models, microrobots, and AI quality control are moving from research into real clinical and manufacturing workflows. 
• bioprinted uterus model for preterm labor drug testing and future personalization 
• ENLIGHT pancreas project using volumetric bioprinting and long viability gels for diabetes research 
• vascularized adipose tissue implants for soft tissue repair and breast reconstruction 
• Singapore biofabrication roadmap focused on sustainable biomaterials and circular supply chains 
• FDA 510(k) cleared titanium spinal implant plus trends in lumbar cage materials and coatings 
• EU MDR certified denture manufacturing and implications for scaled dental 3D printing 
• 3D printed breast cancer locator improving surgical margins with patient-specific guides 
• 3D printed metastasis research platform showing fibroblast protection in blood flow stress 
• brain phantoms and beating heart simulators for realistic surgical training 
• bioprinted cardiac spheroids for studying SARS-CoV-2 heart infection and drug testing 
• microrobots, AI defect prediction, volumetric production methods, and micro-scale printers 
• hospital-made rehab devices cutting costs and a reality check on AI-driven implants 
Please subscribe for more future updates and let us know if anything is missing or incorrect. 

Complete show notes, including links to all articles mentioned in this podcast, are here. 

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About Pitch3D