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In this episode of Journal Club, Ben and Daphna discuss several recent neonatal studies. They begin with a paper from Pediatrics examining variability in care practices for extremely early deliveries (22-24 weeks gestation), highlighting changes over time and persistent differences between centers. They also review a commentary on important questions raised by these variations in care.

The hosts then analyze a study on the use of inhaled nitric oxide in preterm infants, discussing its effectiveness, costs, and potential overuse. They cover a paper on monocyte count trends as a potential diagnostic tool for necrotizing enterocolitis.

A special segment features Dr. Jane Stremming discussing a New England Journal of Medicine study on nutritional support for moderate to late preterm infants. The hosts also touch on new treatments for hemolytic disease of the fetus and newborn, and surfactant use in infants who develop bronchopulmonary dysplasia.

The episode concludes with an ethical case study about a father's unexpected request to withdraw care for his preterm infant, emphasizing the importance of understanding families' perspectives in complex medical decisions.

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Beyond the Question: Reexamining a Parent's Unusual Request.

Callahan KP, Narva A, Stoller JZ, Fiester A.Pediatrics. 2024 Aug 1;154(2):e2023064954. doi: 10.1542/peds.2023-064954.PMID: 39040023

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In this episode of The Incubator podcast, hosts Ben Courchia and Daphna Barbeau welcome Dr. David Askenazi and Dr. Tara Beck to discuss neonatal nephrology. The conversation explores the challenges of defining and diagnosing acute kidney injury (AKI) in newborns, highlighting the variability in nephron numbers at birth and the complexities of interpreting creatinine levels in the first days of life.

The guests discuss the long-term effects of neonatal AKI, the importance of follow-up care, and strategies for supporting kidney health in the NICU and beyond. They emphasize the need for a partnership between neonatology and nephrology to improve outcomes.

Dr. Askenazi introduces the Neonatal Kidney Collaborative (NKC), explaining its mission to advance research, education, and advocacy in neonatal nephrology. Dr. Beck shares her experience as a trainee involved with the NKC, highlighting the mentorship opportunities available.

The episode concludes with a look towards the future of neonatal nephrology research, including potential therapies and the evolving approach to renal replacement therapy in newborns. This informative discussion provides valuable insights for both neonatologists and nephrologists caring for vulnerable newborns.

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As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of the Tech Tuesday podcast, Dr. Yamile C. Jackson, CEO of Nurtured by Design, shares her journey from an engineer to an innovator in the neonatal care space, inspired by her son Zach's premature birth and the challenges she faced in the NICU. Focused on improving the NICU experience for both infants and their families, Yamile developed the Zaky Hug and Zaki Zak, tools designed to provide comfort, support, and safety to hospitalized infants. The conversation dives deep into the concept of kangaroo care, its benefits for premature babies, and how Yamile’s products facilitate this essential practice. By blending personal narrative with practical innovation, the episode illuminates the power of parental touch and involvement in neonatal care, underscoring the need for hospitals to adopt more family-centered approaches. This inspiring story not only showcases Yamile's commitment to enhancing neonatal care but also encourages healthcare professionals to recognize the profound impact of integrating human elements into medical care.

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As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of the Incubator Podcast, Daphna Barbeau and Ben Courchia are joined by Dr. Rachel Fleishman, a neonatologist, writer, and advocate for narrative medicine in neonatal care. Dr. Fleishman shares her journey in discovering the power of storytelling and its potential to humanize and transform the NICU experience for providers, patients, and families alike. She discusses the importance of listening beyond the numbers and medical jargon to truly understand and empathize with the stories of those involved in neonatal care. Dr. Fleishman also explores the role of writing as a tool for personal reflection, healing, and advocacy, emphasizing the value of embracing creativity in medicine. The conversation delves into the challenges and rewards of bridging the gap between the analytical world of medicine and the humanistic approach of narrative, ultimately highlighting the transformative potential of storytelling in the NICU. The episode concludes with an exciting announcement of a collaborative project between Dr. Fleishman and the Incubator Podcast, aimed at fostering a community of neonatal storytellers and showcasing their powerful narratives at the upcoming Delphi Neonatal Innovation Conference.

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As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of The Incubator podcast, we reflect on our recent visit to Nationwide Children's Hospital in Columbus, Ohio. They discuss the welcoming atmosphere and the impressive cohesion among the hospital staff, from the division chief to the fellows and coordinators. We also review a recent JAMA paper on the timing of inguinal hernia repair in preterm infants, highlighting the study's findings and implications for practice.

The main focus of the episode is the upcoming Delphi Conference in Fort Lauderdale, Florida, on September 23-25, 2024. We discuss the conference's unique features, including the NSU Art Museum venue, workshops on point-of-care ultrasound, leveraging AI tools, unit design, and writing and reflection in the NICU. They also introduce the Neonatal Brainiacs trivia competition for fellowship programs and the pitch presentation session for sharing innovative ideas.

Additionally, We announce a special storytelling night during the conference's welcome event, featuring author and neonatologist Dr. Rachel Fleishman. They emphasize the conference's intimate and approachable atmosphere, encouraging attendees to reach out with any questions or concerns. The episode concludes with a reminder about the recently released episodes of the Neonatology Review Podcast and the successful launch of the Beyond the Beeps podcast.

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One NICU mother’s story of resilience in the face of her baby’s multiple medical procedures.

In this conversation, Leah interviews Katia Herminio, a mother of a former 24-week preemie who spent almost four months in the NICU. They discuss Katia's unexpected preterm birth experience, the procedures and surgeries her son underwent, the challenges of breastfeeding, and the setbacks they faced. Katia shares her first time holding her baby, the power of hope, and the strength and resilience she found during their NICU journey. She emphasizes the importance of relying on nurses and doctors to help understand the NICU and having faith in the process.

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In this episode, Ben and Daphna review the latest research on neonatal hyperbilirubinemia, optimistic vs. pessimistic prognostic communication, endotracheal tube sizing, intimate partner violence screening, and congenital CMV outcomes. They also welcome back James Roberts, the founder of the MOM Incubator, to discuss the progress and impact of his innovative mobile incubator system.

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In this episode of “At the Bench”, we are interviewing one of our show’s co-hosts, Dr. David McCulley. David is a neonatologist and developmental biologist at the University of California, San Diego and in this show he talks about what motivated him to build a research program investigating the genetic and developmental mechanisms responsible for congenital diaphragmatic hernia (CDH). David directs an NIH-supported study to determine the genetic mechanisms responsible for abnormal lung and pulmonary vascular development in patients with CDH. He describes the mentorship and collaborative research experiences that have shaped his career path. David also talks about the work that he is doing along with the Society for Pediatric Research and the co-hosts of this program, Dr. Misty Good and Dr. Betsy Crouch, to encourage and promote pediatric physician-scientist career development.

Some highlighted papers:

 Stokes, G., Li, Z., Talaba, N., Genthe, W., Brix, M.B., Pham, B., Wienhold, M.D., Sandok, G., Hernan, R., Wynn, J., Tang, H., Tabima, D.M., Rodgers, A., Hacker, T.A., Chesler, N.C., Zhang, P., Murad, R., Yuan, J.X., Shen, Y., Chung, W.K., McCulley, D.J. Rescuing lung development through embryonic inhibition of histone acetylation. Science Translational Medicine. 2024 Jan 31;16(732). Epub 2024 Jan 31. https://pubmed.ncbi.nlm.nih.gov/38295182/

Qiao, L., Wynn, J., Yu, L., Hernan, R., Zhou, X., Duron, V., Aspelund, G., Farkouh-Karoleski, C., Zygumunt, A., Krishnan, U.S., Nees, S., Khlevner, J., Lim, F.Y., Crombleholme, T., Cusick, R., Azarow, K., Danko, M.E., Chung, D., Warner, B.W., Mychaliska, G.B., Potoka, D., Wagner, A.J., Soffer, S., Schindel, D., McCulley, D.J., Shen, Y., Chung, W.K. Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes. Genetics in Medicine. 2020 Dec;22(12):2020-2028. https://pubmed.ncbi.nlm.nih.gov/32719394/

McCulley, D.J., Wienhold, M.D., Hines, E.A., Hacker, T.A., Rogers, A., Pewowaruk, R.J., Zewdu, R. Chesler, N.C., Selleri, L., Sun, X. PBX transcription factors drive pulmonary vascular adaptation to birth. Journal of Clinical Investigation. 2018 Feb 1;128(2):655-667. https://pubmed.ncbi.nlm.nih.gov/29251627/

Kardon, G., Ackerman, K., McCulley, D.J., Shen, Y., Wynn, J., Shang, L., Bogenschutz, E.L., Sun, X., Chung, W.K. Congenital diaphragmatic hernias: from genes to mechanisms to therapies. Disease Models & Mechanisms. 2017 Aug 1;10(8):955-970. https://pubmed.ncbi.nlm.nih.gov/28768736/

McCulley, D., Wienhold, M.D., Sun, X. “The pulmonary mesenchyme directs lung development.” Current Opinion in Genetics & Development. 2015 Jun;32:98-105. https://pubmed.ncbi.nlm.nih.gov/25796078/

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This episode of the Incubator Podcast, hosted by Ben and Daphna, delves into the significant impact of Point of Care Ultrasound (POCUS) in neonatal care. Featuring experts from the National Neonatal POCUS Collaborative, including Dr. Yogen Singh, Dr. Maria Fraga, Dr. Shazia Bhombal, and Dr. Sai Mukthapuram, the discussion focuses on the advancements in neonatal diagnostics and care through POCUS, the collaborative's goals for standardization and education, and the future of POCUS in enhancing outcomes for neonates.

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As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Dr. Jennifer Harling, a pediatrician and medical missionary in Burundi, shares her experiences and challenges in providing healthcare in a low-resource setting. She discusses the decision to do medical mission work, the background of Burundi and the hospital where she works, the language and cultural challenges she faced, and the improvements she has made in neonatal care. Dr. Harling also talks about staying inspired and connected, her role in medical education, and the importance of finding a balance between work and personal life.

Links mentioned in the episode

https://mccropders.blogspot.com

Dr. Harling’s contact: jenniferb.harling@gmail.com

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In this episode, Dr. David Kaufman discusses his interest in pediatrics and infectious disease, particularly in the prevention and treatment of neonatal infections. He highlights the challenges of antibiotic use in the NICU and the interplay between probiotics, prebiotics, antibiotics, and infections. Dr. Kaufman emphasizes the need for better quality control and standardization of probiotics, as well as the importance of consent and shared decision-making in their use. He also discusses the potential benefits of lactoferrin in reducing necrotizing enterocolitis (NEC) and the future directions in infection management. The episode concludes with a discussion of the Neonatal Antibiotic Stewardship web app.

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In this episode, Dr. Jonathan Swanson discusses the evolution of neonatal nutrition and the major tenants of neonatal nutrition that have been learned over the years. He emphasizes the importance of breast milk and the role it plays in neurodevelopment and short-term outcomes. Dr. Swanson also explores the impact of necrotizing enterocolitis (NEC) on neonatal nutrition and the efforts to prevent NEC through good nutrition and optimizing homeostasis. The conversation then delves into the role of the maternal-fetal dyad in preparing the infant microbiome and the potential for probiotics to re-regulate the microbiome. The discussion concludes with a focus on the challenges and opportunities surrounding the use of probiotics in the NICU, including the role of families in decision-making and the impact of FDA regulations.

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In this episode of Journal Club, hosts Ben and Daphna dive into several impactful studies in neonatology. They begin with a series of papers on patent ductus arteriosus (PDA) management, discussing pharmacological treatments, transcatheter closure techniques, and new clinical practice guidelines. The conversation highlights the evolving landscape of PDA treatment and the need for more robust research.

The hosts also explore a study on diazoxide for neonatal hypoglycemia, examining its effects on glycemic stability and feeding outcomes. They discuss recent findings on infant mortality rates in Texas following abortion restrictions, emphasizing the impact of policy changes on neonatal health outcomes.

Additionally, the episode covers a systematic review of quality improvement interventions to prevent intraventricular hemorrhage in preterm infants, highlighting the complexity of implementing effective "neurobundles".

The hosts conclude with a study on vasopressin as an adjunctive therapy for pulmonary hypertension in term newborns, noting its potential benefits in improving oxygenation and hemodynamic status.

Throughout the episode, Ben and Daphna provide insightful commentary on the clinical implications of these studies, making complex research accessible to listeners while emphasizing the need for continued investigation in key areas of neonatal care.

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In this episode, Dr. Jonathan Blau discusses the FDA warning on probiotics and its implications for the future of probiotic use in the NICU. He expresses mixed feelings about the FDA's involvement and highlights the need for regulation while also expressing concerns about the way the warning was issued. The debate between single-strain and multi-strain probiotics is also discussed, with Dr. Blau emphasizing the importance of using the triple strain recommended by ESPAGAN and AAP. He shares his experiences with rolling out probiotics in his NICU, including the decision-making process and the involvement of different disciplines. The administration and preparation of probiotics, as well as the consent and assent process, are also explored. Dr. Blau concludes by discussing the outcomes of probiotic use in his NICU and the ethical considerations surrounding the use of probiotics.

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In this episode, Dr. Jonathan Blau discusses the evidence for probiotics in the prevention of necrotizing enterocolitis (NEC) in the neonatal intensive care unit (NICU). He explains that the history of probiotics in neonatology spans almost 20 years, with meta-analyses showing a significant reduction in NEC rates. The pathophysiology of NEC is related to dysbiosis in premature infants, and probiotics aim to restore a healthy microbiome. The use of probiotics varies internationally, with Europe and Canada having higher rates of use compared to the United States. Dr. Blau also discusses the optimal study design for probiotics and the potential benefits beyond NEC prevention.

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As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of the Incubator Podcast, Ben and Daphna discuss maternal mental health with Maureen Fiora, CEO of Mammha, a femtech startup aimed at revolutionizing maternal mental health care. Mammha focuses on addressing postpartum and perinatal depression by improving identification, diagnosis, referral, and treatment processes. Maureen shared her personal journey, highlighting the significant gaps in current healthcare systems regarding maternal mental health, emphasizing that less than 20% of physicians screen for these conditions. She detailed how Mammha streamlines screening with technology and ensures that women who screen positive receive comprehensive follow-up care, overcoming the usual fragmentation in care pathways.

The conversation also touched on the importance of screening in NICUs due to the heightened vulnerability of parents there, with Mammha capturing significant data on both mothers and fathers experiencing mental health issues. Maureen explained how Mammha operates, starting with provider-initiated screening using QR codes and validated tools, to engaging care coordinators for immediate follow-up. The company's success stories include partnerships and awards for their innovative approach to closing care gaps, especially among underserved populations.

Mammha's model has significantly increased engagement and follow-up care for screened parents, showcasing a promising pathway to better maternal mental health outcomes. Maureen's background in policy and advocacy, combined with personal experience, positions her uniquely to lead this initiative, aiming to make a tangible difference in the lives of parents navigating the challenges of mental health during the perinatal period.

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In this week’s episode of The Incubator Podcast, hosts Ben Courchia, MD, and Daphna Yasova Barbeau, MD, dive into the complex world of neonatal care for infants with congenital heart disease. 

Our guest, Dr. Nim Goldshtrom, shares insights from his extensive experience in neonatology and pediatric cardiac intensive care, focusing on the multidisciplinary approach to caring for the sickest infants at Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital. Dr. Goldshtrom discusses the evolution of his career, the importance of specialized training for dealing with congenital heart disease in neonates, and how modern technology like near-infrared spectroscopy (NIRS) is being used to improve patient outcomes. The conversation also touches on the challenges and opportunities presented by genetic screening and the future directions of neonatal and congenital heart disease care. Join us for an enlightening discussion that sheds light on the nuanced care required for these vulnerable patients and the ongoing advancements in the field.

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Hello Friends,

We have a new episode of journal club for you this week. On this episode Ben & Daphna review the latest research in neonatology, and welcome the EBNEO team for a new commentary. The articles reviewed this week include:

Esophageal versus Rectal Temperature Monitoring during Whole-body Therapeutic Hypothermia for Hypoxic-ischemic Encephalopathy: Association with Short and Long-term Outcomes. Wu TW, Schmicker R, Wood TR, Mietzsch U, Comstock B, Heagerty PJ, Rao R, Gonzalez F, Juul S, Wu YW.J Pediatr. 2024 Feb 1:113933. doi: 10.1016/j.jpeds.2024.113933. Online ahead of print.PMID: 38309524 Free article.

Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK, Håberg S, Stephansson O.JAMA. 2024 Feb 6;331(5):396-407. doi: 10.1001/jama.2023.26945.PMID: 38319332

Maternal syphilis rates tripled in the US between 2016 and 2022, data show. Tanne JH.BMJ. 2024 Feb 15;384:q416. doi: 10.1136/bmj.q416.PMID: 38359912 No abstract available.

 Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy. Kim SH, El-Shibiny H, Inder T, El-Dib M.J Perinatol. 2024 Jan 16. doi: 10.1038/s41372-024-01874-x. Online ahead of print.PMID: 38228763

Randomised study of a new inline respiratory function monitor (Juno) to improve mask seal and delivered ventilation with neonatal manikins. Tracy MB, Hinder M, Morakeas S, Lowe K, Priyadarshi A, Crott M, Boustred M, Culcer M.Arch Dis Child Fetal Neonatal Ed. 2024 Feb 9:fetalneonatal-2023-326256. doi: 10.1136/archdischild-2023-326256. Online ahead of print.PMID: 38336472

Dextrose gel prophylaxis for neonatal hypoglycaemia and neurocognitive function at early school age: a randomised dosage trial. Wei X, Franke N, Alsweiler JM, Brown GTL, Gamble GD, McNeill A, Rogers J, Thompson B, Turuwhenua J, Wouldes TA, Harding JE, McKinlay CJD; pre-hPOD Early School-age Outcomes Study Group.Arch Dis Child Fetal Neonatal Ed. 2024 Feb 12:fetalneonatal-2023-326452. doi: 10.1136/archdischild-2023-326452. Online ahead of print.PMID: 38307710

Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial. Jensen, G. B., Domellöf, M., Ahlsson, F., Elfvin, A., Navér, L., & Abrahamsson, T. eClinicalMedicine (2023).

Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial. Colaizy TT, Poindexter BB, McDonald SA, et al. JAMA. 2024;331(7):582–591. doi:10.1001/jama.2023.27693

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EBNEO Commentary: De-MIST-ifying the 2-year outcomes of non-invasive surfactant therapy. Loft L, Ferguson KN, Tingay DG.Acta Paediatr. 2024 Jan 25. doi: 10.1111/apa.17116. Online ahead of print.

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Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial. Jensen, G. B., Domellöf, M., Ahlsson, F., Elfvin, A., Navér, L., & Abrahamsson, T. eClinicalMedicine (2023).

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Esophageal versus Rectal Temperature Monitoring during Whole-body Therapeutic Hypothermia for Hypoxic-ischemic Encephalopathy: Association with Short and Long-term Outcomes. Wu TW, Schmicker R, Wood TR, Mietzsch U, Comstock B, Heagerty PJ, Rao R, Gonzalez F, Juul S, Wu YW.J Pediatr. 2024 Feb 1:113933. doi: 10.1016/j.jpeds.2024.113933. Online ahead of print.PMID: 38309524 Free article.

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Summary
Dr. Eliza Myers, an academic neonatologist, shares her journey in neonatology and her passion for combining art and medicine. She discusses the importance of pursuing personal passions and making time for hobbies. Dr. Myers also highlights the role of visual arts in medicine and the impact it has on creativity and problem-solving. She then delves into her dedication to breastfeeding and lactation, including the development of the Track My Milk app. She explains the process of building the app and its integration into the electronic medical record system. Dr. Myers emphasizes the importance of parent compliance and engagement in using the app and the positive impact it has on the bedside experience. She also discusses the collaboration between physicians and lactation specialists and the support needed for trainees with unique ideas. Finally, Dr. Myers shares her thoughts on expanding the app to other electronic medical record systems and the challenges and rewards of the development process. In this conversation, Eliza Myers discusses her work on Track My Milk, a mobile app for tracking breast milk production. The conversation covers challenges of collaboration, the impact of technology on research in medicine, the importance of parent engagement and data collection, the potential of artificial intelligence in healthcare, and the exploration of brain microstructure in neonatology. The conversation concludes with a discussion on the future of Track My Milk and its potential dissemination.

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In this episode of “At the Bench”, we have the privilege of interviewing one of our hosts, Dr. Misty Good. Dr. Good discusses her amazing career journey from learning to pipette water at the beginning of her neonatology fellowship to becoming a multiple R01-funded investigator. She shares how she is inspired every day to improve the care of preterm infants with necrotizing enterocolitis through her research and how she decided to pursue a career as a physician-scientist due to the desire to improve the lives of all babies. Dr. Good’s story serves as an inspiration to early career faculty and those navigating the challenging but incredibly rewarding career path of a neonatologist-scientist. 

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Diazoxide for Severe or Recurrent Neonatal Hypoglycemia: A Randomized Clinical Trial.

Laing D, Walsh EPG, Alsweiler JM, Hanning SM, Meyer MP, Ardern J, Cutfield WS, Rogers J, Gamble GD, Chase JG, Harding JE, McKinlay CJD.JAMA Netw Open. 2024 Jun 3;7(6):e2415764. doi: 10.1001/jamanetworkopen.2024.15764.PMID: 38869900 Free PMC article. Clinical Trial.

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In this week's episode of The Incubator Podcast's Journal Club, Ben and Daphna delve into recent pivotal studies impacting neonatal intensive care. Their expert discussion navigates through the latest research findings, offering deep insights for professionals in the field. Highlights include:

• Hydrocortisone in Preterm Neonates for BPD Prevention: A detailed analysis of hydrocortisone's role in preventing bronchopulmonary dysplasia, based on a systematic review and meta-analysis.
• Factors Influencing CRP Status in Neonates: An exploration of the determinants affecting C-reactive protein levels, with a focus on gestational age, birth weight, and specific maternal and neonatal conditions.
• Transition to Adulthood for Extremely Preterm Survivors: Insights from a longitudinal study on the long-term outcomes of extremely preterm/low birth weight survivors in education, employment, and health.
• Sustained Inflation and Chest Compression in Neonatal CPR: A comparison of CPR methods for asphyxiated newborns, evaluating sustained inflation versus traditional compression to ventilation ratios.
• Early vs. Late Tracheostomy in Infants with Severe BPD: An examination of the neurodevelopmental outcomes associated with the timing of tracheostomy in infants with severe BPD and the impact of postnatal steroid exposure.

Join us for a deep dive into these topics, designed to inform and challenge the current understanding and practices in neonatal care.

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Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.

Pirlotte S, Beeckman K, Ooms I, Cools F.Cochrane Database Syst Rev. 2024 Jan 18;1(1):CD013353. doi: 10.1002/14651858.CD013353.pub2.PMID: 38235838

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Daily skin-to-skin contact alters microbiota development in healthy full-term infants.

Eckermann HA, Meijer J, Cooijmans K, Lahti L, de Weerth C.Gut Microbes. 2024 Jan-Dec;16(1):2295403. doi: 10.1080/19490976.2023.2295403. Epub 2024 Jan 10.PMID: 38197254 Free PMC article. Clinical Trial.

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The impact of early tracheostomy on neurodevelopmental outcomes of infants with severe bronchopulmonary dysplasia exposed to postnatal corticosteroids.

Taha A, Akangire G, Noel-Macdonnell J, Gladdis T, Manimtim W.J Perinatol. 2023 Dec 29. doi: 10.1038/s41372-023-01864-5. Online ahead of print.PMID: 38158399

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Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns (SURV1VE): A cluster randomised controlled trial.

Schmölzer GM, Pichler G, Solevåg AL, Law BHY, Mitra S, Wagner M, Pfurtscheller D, Yaskina M, Cheung PY; SURV1VE- Trial Investigators.Arch Dis Child Fetal Neonatal Ed. 2024 Jan 11:fetalneonatal-2023-326383. doi: 10.1136/archdischild-2023-326383. Online ahead of print.PMID: 38212104

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https://www.kare11.com/article/news/local/islamic-legal-solves-donated-breast-milk-quandary-for-muslim-parents/89-5fb4a3f3-3646-4601-89c0-a2de6c9ef684

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Transition to Adulthood for Extremely Preterm Survivors.

Pigdon L, Mainzer RM, Burnett AC, Anderson PJ, Roberts G, Patton GC, Cheung M, Wark JD, Garland SM, Albesher RA, Doyle LW, Cheong JLY; Victorian Infant Collaborative Study Group.Pediatrics. 2024 Jan 1;153(1):e2022060119. doi: 10.1542/peds.2022-060119.PMID: 38124530

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Factors influencing C-reactive protein status on admission in neonates after birth.

Cao C, Wang S, Liu Y, Yue S, Wang M, Yu X, Ding Y, Lv M, Fang K, Chu M, Liao Z.BMC Pediatr. 2024 Feb 1;24(1):89. doi: 10.1186/s12887-024-04583-8.PMID: 38302903 Free PMC article.

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Hydrocortisone in very preterm neonates for BPD prevention: meta-analysis and effect size modifiers.

De Luca D, Ferraioli S, Watterberg KL, Baud O, Gualano MR.Arch Dis Child Fetal Neonatal Ed. 2024 Jan 17:fetalneonatal-2023-326254. doi: 10.1136/archdischild-2023-326254. Online ahead of print.PMID: 38237961

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In this episode, Shelly-Ann, Ben, and Gabriel discuss the Newborn Toolkit with Dr. Joy Lawn, Dr. Mbozu Sipalo, and Lauren Allison from the Newborn Toolkit Team. They highlight the importance of newborn care, the challenges faced in providing adequate care globally, and the development of the Newborn Toolkit to address these challenges. 

Newborn Toolkit link - https://newborntoolkit.org/toolkit

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Vasopressin as adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension in term newborns.

Santelices F, Masoli D, Kattan J, Toso A, Luco M.J Perinatol. 2024 Jul 4. doi: 10.1038/s41372-024-02015-0. Online ahead of print.PMID: 38965377

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In this episode of The Incubator, hosts Ben and Daphna discuss Bronchopulmonary Dysplasia (BPD) with Dr. Steve Abman, Dr. Milenka Cuevas Guaman, and Dr. Laurie C. Eldredge from the BPD Collaborative. They cover the progression of BPD understanding, emphasizing the collaborative efforts in neonatology, the critical role of interdisciplinary care, and current approaches to improve patient outcomes.

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In this episode of The Incubator Podcast, hosts Ben and Daphna sit down with Tracy Warren, co-founder and CEO of Astarte Medical, to discuss the NICUtrition tool. They delve into how NICUtrition is tailored to improve nutritional outcomes in premature infants, its development journey, and real-world application insights.

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In the latest episode of the Incubator Podcast's Journal Club, the hosts, Ben and Daphna, delve into a detailed discussion of recent neonatology research.

• The Oscar Trial: Examined the efficacy of early ibuprofen treatment for large patent ductus arteriosus (PDA) in extremely preterm infants to improve outcomes like survival and severe bronchopulmonary dysplasia (BPD). The study, a randomized double-blind placebo-controlled trial across 32 UK units, found no significant benefit of early ibuprofen treatment.
• Breastfeeding as a Protective Factor Against BPD: A retrospective study from the British Journal of Nutrition by José Uberos, focusing on the intake of mother's own milk, donor human milk, or preterm formula within the first two weeks of life in very low birth weight infants. It highlighted the benefits of mother's milk in reducing the odds of BPD and noted the importance of enteral nutrition in the development of BPD.
• Clinical Chorioamnionitis and Neurodevelopment: Drawn from the Epipage to cohort, the study found no significant association between clinical chorioamnionitis and neurodevelopmental disorders at five years of age for infants born between 24 and 34 weeks of gestation.
• Polyethylene Bags Before Cord Clamping: This randomized control trial published in the Archives of Disease in Childhood investigated whether placing very preterm infants in a polyethylene bag before cord clamping could ensure normothermia upon NICU admission. The trial concluded that there was no significant difference in the normothermia rates between those bagged before and after cord clamping.
• Marijuana Use and Breastfeeding: Survey results from a Pediatrics journal article showing variability in hospital practices regarding breastfeeding for mothers who use marijuana. It calls for more standardized, evidence-based practices to ensure healthcare equity.
• Platelet Transfusion and Neurodevelopmental Impairment: A JAMA Network Open study using data from the PEANUT trial, examining the association between platelet transfusion exposure and death or severe neurodevelopmental impairment at two years of age in extremely preterm children.
• Azithromycin During Routine Well Infant Visits: A study from Burkina Faso published in the New England Journal of Medicine tested the effectiveness of Azithromycin given during routine health care visits in preventing infant mortality. The results did not support the prophylactic use of Azithromycin for this purpose.
• Challenges in Managing Refractory Pain and Sedation in Infants: A review article from Frontiers in Pharmacology compiling guidelines and providing insights into the management of pain, sedation, and withdrawal in infants, including the issue of delirium in the NICU setting.
• EBNEO Commentary with Dr. Eugene How and Dr. Cami Martin on the study by Ariel Salas et al published in Pediatrics: Early human milk fortification in infants born extremely preterm: A randomised trial. 

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Support the show

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Support the show

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Support the show

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Welcome to “At the Bench” a new podcast in the Incubator network focusing on physician-scientists in neonatology, their research, and career journeys. 

This week, we start by interviewing Dr. Elizabeth “Betsy” Crouch, a neonatologist, neuroscientist, and vascular biologist at the University of California, San Francisco. Dr. Crouch’s lab takes a “Vascular-centric” perspective to neurodevelopment and studies how the blood vessels in the developing brain and spinal cord impact the growing neural cells, and vice versa. In part, this approach is inspired by germinal matrix hemorrhage, a devastating condition unfortunately common in the NICU that can cause cerebral palsy, hydrocephalus, and death. Early in Dr. Crouch’s training, a family she cared for in the NICU questioned the status quo in germinal matrix hemorrhage management. They asked why, in this era of modern medicine, their baby had no treatment options for this devastating and common condition. This anecdote highlights what has become a theme in her research: basic and translational science inspired by parents and patients. Her lab now focuses on defining the stages of vascular stem cells in the developing brain and understanding the mechanisms that regulate their functions, applying this knowledge to produce novel technologies and therapeutic strategies for different brain hemorrhages in neonatal and pediatric patients. This episode discusses the challenges and victories in Dr. Crouch’s journey, her mentors and their wisdom, and how we might create a future without germinal matrix hemorrhage for our premies and their families.

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In this episode of the incubator, Dr. Nora Colman, a pediatric critical care physician, and Sarah Walter, a registered architect and senior medical planner, delve into the intricacies of designing Neonatal Intensive Care Units (NICUs). They explore the impact of the built environment on neonatal care, emphasizing evidence-based design and the need for healthcare architecture to support patient outcomes. Discussions revolve around how elements like lighting, noise, and spatial design influence both the health of newborns and the efficiency of care. The episode underscores the importance of collaboration between healthcare professionals and architects in creating optimal NICU environments, with real-world examples and innovative approaches highlighted.

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Dr. Kunda Mutesu-Kapembwa is a Paediatrician and Neonatologist working in Zambia. She holds a Bachelor of Medicine and Surgery, a Master in Paediatrics and Child Health, a Certificate and Master of Philosophy in Neonatology. Her career is dedicated to nursing and doctors’ education and to the health of neonates and their families. She Co-founded Newborn Support Zambia, a not for profit Non-Governmental Organization to help improve the care of neonates in Zambia.

https://www.the-incubator.org/post/176-global-neonatal-pod-pioneering-neonatology-in-zambia-with-dr-kunda-mutesu-kapwemb

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1. A trial on using sildenafil for brain injury in neonates with hypoxic-ischemic encephalopathy (HIE). The safety and feasibility of sildenafil as a restorative treatment are explored.
2. The effectiveness of NIR-CIVIMAB for RSV prevention in infants. The focus is on reducing hospitalizations due to RSV-associated lower respiratory tract infections.
3. The impact of antenatal corticosteroid treatment during late preterm periods on neonatal outcomes, especially in twin pregnancies.
4. A study on energy drink intake before and during pregnancy and its association with adverse pregnancy outcomes.
5. Jennifer Canvasser's meeting with the FDA regarding probiotic use in NICUs and the implications of recent FDA warnings.
6. Research on early and exclusive enteral nutrition in preterm infants, the time taken to reach target cooling temperature in infants with HIE, and the potential role of blood transfusions in bronchopulmonary dysplasia.

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Procedural closure of the patent ductus arteriosus in preterm infants: a clinical practice guideline.

Mitra S, Bischoff AR, Sathanandam S, Lakshminrusimha S, McNamara PJ.J Perinatol. 2024 Jul 12. doi: 10.1038/s41372-024-02052-9. Online ahead of print.PMID: 38997403 Review.

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Early and exclusive enteral nutrition in infants born very preterm.Razzaghy J, Shukla VV, Gunawan E, Reeves A, Nguyen K, Salas AA.Arch Dis Child Fetal Neonatal Ed. 2023 Dec 22:fetalneonatal-2023-325969. doi: 10.1136/archdischild-2023-325969. Online ahead of print.PMID: 38135494

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Positioning for lumbar puncture in newborn infants. Pessano S, Bruschettini M, Prescott MG, Romantsik O.Cochrane Database Syst Rev. 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3.PMID: 38096386 Review.

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Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): A randomized, double-blind, placebo-controlled phase Ib clinical trial. Wintermark P, Lapointe A, Steinhorn R, Rampakakis E, Burhenne J, Meid AD, Bajraktari-Sylejmani G, Khairy M, Altit G, Adamo MT, Poccia A, Gilbert G, Saint-Martin C, Toffoli D, Vachon J, Hailu E, Colin P, Haefeli WE.J Pediatr. 2023 Dec 21:113879. doi: 10.1016/j.jpeds.2023.113879. Online ahead of print.PMID: 38142044 Free article.

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