Explore every episode of the podcast The Human Upgrade: Biohacking for Longevity & Performance
| Title | Pub. Date | Duration | |
|---|---|---|---|
| How to Live Healthier Without Obsessing Over Health : 1550 | 06 oct. 2026 | 00:51:49 | |
Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time. Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped spark her lifelong interest in organic living, holistic health, and reducing unnecessary exposures. That experience later became a driving force behind KORA Organics and her focus on certified organic skincare. They explore the habits Miranda now prioritizes after years of experimenting with wellness, including morning sunlight, quality food, meditation, sleep, breathwork, strong relationships, and time with family. She also explains how she manages stress while raising four children and running an international company. Dave and Miranda discuss raising healthy kids without making health feel restrictive, navigating different health values within a family, and why acceptance matters when you cannot control another person’s choices. The episode also covers clean beauty, plant-based retinol alternatives, non-nano zinc sunscreen, essential oils, rose quartz, intention, and the philosophy behind KORA Organics. Miranda also explains why constantly chasing new wellness tools eventually pushed her back toward a smaller set of foundational habits that consistently make her feel better. This episode is essential listening for anyone interested in clean living, stress reduction, meditation, sleep, healthy parenting, skincare, organic beauty, biohacking, and building a wellness routine that supports your life rather than taking it over. You’ll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Miranda Kerr, KORA Organics, clean living, clean beauty, wellness, healthy living, holistic health, skincare, organic skincare, certified organic skincare, healthy skin, anti-aging skincare, skin health, non-nano zinc sunscreen, mineral sunscreen, retinol alternative, bakuchi oil, meditation, TM meditation, breathwork, stress reduction, stress management, sleep, circadian rhythm, morning sunlight, blue light, grounding, healthy parenting, raising healthy kids, nutrition, toxins, environmental toxins, ingredient safety, essential oils, rose quartz, mindset, intention, biohacking, healthy aging, wellness routine, simple wellness, holistic wellness Resources: • Grab 20% Off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. Timestamps: 00:00 — Trailer 00:51 — Miranda’s Health Awakening 06:21 — Mind, Body & Crystals 13:12 — Roots of Positive Thinking 17:04 — The McDonald's Birthday Hack 22:36 — Acceptance in Relationships 28:34 — Intention Behind the Products 32:28 — Proving Organic Skincare Works 36:56 — Stress & Morning Rituals 42:09 — Back to Basics 48:17 — Health Without Public Pressure 51:06 — Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549 | 04 oct. 2026 | 00:19:07 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that helped me lose over 100 pounds, kill brain fog, and feel two decades younger, starting with something as simple as what I put in my morning coffee. If you're tired of doing everything 'right' and still feeling old, this one's for you. You'll Learn:
Timestamps: 00:00 — The 300-Pound Millionaire 01:26 — Discovery in Tibet 03:05 — Eat More Saturated Fat 04:38 — The Low-Fat Scam 07:01 — Quality Over Quantity 09:20 — Hidden Plant Toxins 12:04 — Watch the Fructose 13:08 — Skip Breakfast 16:38 — Diet Beats the Gym Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/discount/dave15? Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Join my Substack: https://substack.daveasprey.com Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548 | 02 oct. 2026 | 00:10:37 | |
Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer device will reproduce the study’s results.pubmed.ncbi.nlm.nih+1 Sources: https://pubmed.ncbi.nlm.nih.gov/36150665/ https://pmc.ncbi.nlm.nih.gov/articles/PMC13214873/ ~~~ Nearly 500 Cat Tumors Reveal Cancer Genes Shared With Humans Researchers analyzed 493 matched tumor and normal-tissue samples across 13 types of cancer in domestic cats. They found alterations in genes familiar to human cancer researchers, including TP53, and tested whether a mutation called FBXW7 might predict drug sensitivity in lab-grown models of feline mammary tumors. Host Dave Asprey examines why naturally occurring cancers in pets could help scientists investigate treatments across species, while making clear that a promising response in six laboratory tumor models is not a proven treatment for cats or people.pmc.ncbi.nlm.nih Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC7618901/ https://pubmed.ncbi.nlm.nih.gov/41712721/ https://www.sciencedaily.com/releases/2026/09/260924231826.htm ~~~ Twin-Family Study Challenges a Simple Explanation for Inherited Intelligence Why do parents and children often score similarly on tests of cognitive ability? Researchers using Germany’s TwinLife data found that genetic transmission explained more of that resemblance than the particular shared-home-environment pathway their model tested. Host Dave Asprey unpacks the distinction between why relatives resemble one another and whether a child’s environment matters. The study does not show that parenting, education, or other experiences have no effect on cognition.pub.uni-bielefeld+1 Sources: https://pub.uni-bielefeld.de/record/2993432 ~~~ Mulberry Compounds May Change Gut Bacteria and Metabolism A review of mulberry research highlights how leaves, fruit, and differently processed extracts contain distinct mixtures of compounds that gut microbes may use. In mouse experiments, a fraction combining mulberry polyphenols and polysaccharides produced more favorable microbiome and metabolic changes than either fraction alone; transferring microbes from treated mice passed along some of those effects. Host Dave Asprey explores the idea that a plant extract’s preparation may matter as much as its name—and why the findings do not yet establish a microbiome benefit from mulberry products in humans.pmc.ncbi.nlm.nih+1 Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC13406227/ https://www.sciencedaily.com/releases/2026/09/260928100551.htm ~~~ Magnesium Changes Vitamin D Metabolism—But Not Always in the Same Direction Magnesium helps regulate the pathways that process vitamin D, but “more magnesium means more vitamin D” is too simple. In a 12-week randomized trial involving 180 adults, magnesium supplementation changed a measured vitamin D metabolite differently depending on participants’ starting vitamin D levels: the modeled difference was positive at 30 ng/mL and negative at 50 ng/mL. Host Dave Asprey explains why this matters to people tracking supplement stacks and bloodwork, while distinguishing a change in a lab marker from a demonstrated health benefit.pubmed.ncbi.nlm.nih+1 Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC6693398/ https://pubmed.ncbi.nlm.nih.gov/29480918/ https://www.sciencedaily.com/releases/2018/02/180226122548.htm This episode is designed for biohackers, longevity enthusiasts, pet owners, parents, and anyone trying to separate a compelling biological mechanism from a proven health intervention. Host Dave Asprey examines brain stimulation and memory, what cat cancers could teach human researchers, how genes and environment contribute to cognitive similarity, whether mulberry’s microbiome effects translate beyond mice, and why nutrient interactions are rarely as simple as a supplement headline suggests. Several studies discussed here predate this week’s coverage; this is a research roundup, not a list of five newly published trials.pmc.ncbi.nlm.nih+4 New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: vagus nerve stimulation memory, auricular vagus nerve stimulation, mild cognitive impairment, Alzheimer’s research, locus coeruleus, cat cancer genetics, feline oncogenome, FBXW7 feline mammary cancer, comparative oncology, parent child cognitive ability, TwinLife cognitive ability study, intelligence genetics, shared environment cognition, mulberry gut microbiome, mulberry polyphenols polysaccharides, microbiota transfer mice, magnesium vitamin D metabolism, magnesium supplementation vitamin D, biohacking research roundup Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 — Intro 00:18 — Vagus Nerve 01:51 — Cat Cancer 03:53 — Genetics & Parenting 05:46 — Mulberries 07:43 — Magnesium & Vitamin D 09:25 — Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547 | 01 oct. 2026 | 00:47:03 | |
Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer. Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health. Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging. The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair. Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging. They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light. The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science. They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized. This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare. You’ll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity Resources: • Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Thank you to our sponsors! - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Timeline | Go to timeline.com/dave and get up to 20% off when you subscribe and save - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Timestamps: 00:00 — Trailer 01:09 — Skin Testing & Metabolomics 04:48 — Longevity Skincare Paradigm 07:50 — Airplane Skincare Routine 11:15 — Tardigrade Juice & Antioxidants 16:00 — Mitochondrial Dysfunction 21:00 — Skincare Ingredients: Old vs New 27:20 — Vampire Exosomes 32:30 — Red Light Therapy Stacking 38:00 — Proteomics & Klotho 41:00 — Exosome Safety, Growth Factors & MicroRNAs 44:00 — Senescent Cells & Senomorphics 47:00 — Skin Longevity Takeaways 50:00 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546 | 29 sept. 2026 | 00:56:58 | |
Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity. Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis. Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver. The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process. Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation. This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking. You’ll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking Resources: • Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com. Timestamps: 00:00 — Trailer 01:00 — Liver Basics & Signs 05:30 — Liver Scan Technology 08:15 — Chemicals & Liver Disease 11:30 — Deliverance Formula Story 17:15 — Estrogen, Alcohol & HRT 22:30 — GLP-1s & Liver Toxicity 28:00 — Bile & Gut Health 33:10 — Chimerism & Transplants 41:30 — Hormesis & Painkillers 50:00 — Sweeteners, Hormones & Thyroid 55:00 — Outro - Discount See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545 | 27 sept. 2026 | 00:14:24 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction. If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off. You'll Learn:
Thank you to our sponsors!
Timestamps: 00:00 — Introduction & Calorie Myth 01:27 — Power of Protein 02:37 — Cut Sugar & Carbs 03:48 — HIIT for Fat Loss 05:44 — Cold Exposure 06:32 — Resistance Training 08:22 — Sleep & Growth Hormone 10:30 — Stress & Cortisol 13:39 — Breaking the Fat Loop Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544 | 25 sept. 2026 | 00:14:40 | |
Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness. Sources: https://www.novonordisk.com/investors/capital-markets-day-2026.html https://www.irishexaminer.com/business/companies/arid-41914219.html ~~~ Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth. Sources: https://doi.org/10.1177/21532176261486979 https://www.sciencedaily.com/releases/2026/09/260923035926.htm ~~~ Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites. Sources: https://www.nature.com/articles/s44220-025-00468-6 https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html ~~~ Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods. Sources: https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203 https://link.springer.com/article/10.1186/s12916-026-05132-z ~~~ Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives. Sources: https://www.nature.com/articles/s41598-017-05051-3 https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/ This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026 Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 — Intro 00:18 — Novo Nordisk & Hair Loss 02:52 — GLP-1s & Kids' Nutrition 05:08 — Stomach-Brain Sync 07:49 — Preservatives & Heart Risk 10:53 — Taurine & Stress Resilience 13:28 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Best Singular Hack To Change EVERYTHING About Your Life : 1543 | 24 sept. 2026 | 01:13:45 | |
Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive. Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study:
Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:
You'll Learn:
Resources: • Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 — Introduction & the Study 04:43 — What Makes a Good Life 08:47 — How Relationships Heal 13:44 — Happiness: Nature vs Nurture 17:59 — Measuring Happiness 23:56 — Life Stages & Happiness 35:34 — Social Fitness 44:30 — Energizing Relationships 56:14 — Attachment & Childhood 1:05:04 — Casual Friends & Legacy Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| 15g Every Morning for Anti-Aging Mitochondria : 1541 | 22 sept. 2026 | 00:58:42 | |
Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity? Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author of Love Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these microscopic organisms have been studied for decades as unusually nutrient-dense foods. Catharine explains the major differences between spirulina and chlorella, from how they are grown and processed to how she uses them for completely different purposes. Spirulina contains compounds including phycocyanin and superoxide dismutase that Catharine believes can support mitochondrial function, antioxidant defenses, cellular energy, and brain health, while chlorella is used primarily for binding and removing unwanted compounds such as heavy metals. They also discuss why water quality, sourcing, drying temperature, and processing can dramatically change the final product. The conversation goes deep into mitochondrial biology, including the electron transport chain, ATP production, oxidative stress, free radicals, cytochrome c, superoxide dismutase, and the blue pigment phycocyanin. Dave connects these mechanisms to his own experience rebuilding mitochondrial function and explains why increasing cellular energy without adequate antioxidant defenses may create problems, particularly for people experimenting with advanced longevity interventions such as mitochondrial peptides. Dave and Catharine also explore methylene blue, psychedelics, exercise, brain aging, environmental toxins, nutrient density, food quality, algae farming, sustainable agriculture, and why maintaining mitochondrial function may become increasingly important with age. Catharine, who turns 70 shortly after the recording, also shares the philosophy behind her first book and her belief that aging does not have to mean accepting declining energy and cognitive function. This is essential listening for anyone interested in mitochondria, spirulina, chlorella, cellular energy, brain health, detoxification, oxidative stress, longevity, biohacking, nutrient density, methylene blue, peptides, and maintaining performance as you age. You’ll Learn:
Dave Asprey is 4x NY Times Bestselling Author, Longevity Expert and Creator of the Biohacking Movement. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Catharine Arnston, ENERGYbits, spirulina, chlorella, algae, microalgae, mitochondrial health, mitochondria, cellular energy, ATP production, electron transport chain, oxidative stress, free radicals, superoxide dismutase, SOD, phycocyanin, brain health, detoxification, heavy metals, glyphosate, environmental toxins, methylene blue, MOTS-c, peptides, biohacking, longevity, healthy aging, nutrient density, antioxidant defense, sustainable food Resources: • Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Timestamps: 00:00 — Show Open 01:25 — Algae Origins & History 06:15 — Sourcing Quality Algae 09:15 — Nutrient Density Crisis 17:15 — Spirulina vs. Chlorella 22:30 — Algae Industry Applications 27:45 — Algae in Your Cells 33:20 — SOD & Brain Health 42:00 — Phycocyanin & Cancer 52:30 — Aging vs. Declining See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| I Wasted 10 Years Stuck With Brain Fog Until I Learned This : 1540 | 20 sept. 2026 | 00:20:31 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey If you're waking up exhausted, foggy, or inflamed and nothing seems to fix it, the answer might be hiding in your walls. This deep dive walks through how toxic mold and mycotoxins settle into your brain, nerves, and mitochondria, how to properly test your home and body for exposure, and the exact order of operations, environment first, then detox, that actually leads to recovery. Drawing from his own diagnosis with mold-related brain damage, the creator breaks down everything from HVAC contamination to binders and glutathione so you can finally stop chasing symptoms and address the real source. Thank you to our sponsors!
Timestamps: 00:00 — Mold Toxins and My Story 02:14 — How Mycotoxins Damage Cells 04:09 — Three Sources of Mold 05:35 — Track Symptoms by Location 07:20 — Fix Environment Before Detox 08:53 — Mold Testing Methods 10:35 — Remediation and Moisture Control 12:47 — Belongings Can Recontaminate 14:45 — Why Recovery Varies 17:23 — Detox Protocol and Binders Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539 | 18 sept. 2026 | 01:02:36 | |
Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species? These are just a few of the big questions you’ll tackle in this enlightening and esoteric episode re-run. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability to talk about psychology, shadow work, and the nature of our world. Teal shares the unusual and special way she sees the world. We talk about her ESP powers, how to identify a narcissist, and her favorite dimensions. We also get into the divine masculine vs. the divine feminine, the nature of ego, and how to build trust in the world and others. 00:00 — Trailer 00:18 — Intro 6:12 — Understanding Narcissism 13:20 — AI and Spiritual Perception 19:30 — Birth Trauma and Memory 28:00 — Art and Different Realities 35:22 — The Nature of Ego 42:50 — Divine Masculine and Feminine 50:00 — Hormones and Hope 54:05 — Synchronization Workshops 1:00:29 — Outro Sponsors
Resources: • Learn More About Teal's Work At: https://tealswan.com/about-teal/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538 | 17 sept. 2026 | 00:54:16 | |
Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function. **Visit https://memoryair.com/ and use code DAVE15 for 15% off. ** Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world’s most cited scientists, to explore why smell may be one of the most overlooked tools for brain health and longevity. Dr. Leon explains why the olfactory system has unusually direct access to the brain’s memory and emotional centers, why smell often declines alongside memory after age 60, and why reduced olfactory function has been associated with Alzheimer’s disease, cognitive decline, depression, and increased all-cause mortality. They also discuss how COVID, chronic congestion, pollution, stress, and aging can impair smell without people realizing it. The conversation dives into olfactory enrichment, including research showing major improvements in memory when older adults were exposed to multiple scents during sleep. Dr. Leon explains why novelty matters, how nighttime scent exposure may increase deep sleep and reduce nightmares, and why olfactory stimulation is being studied in dementia, PTSD, depression, and autism. Dave also explores connections between smell, GLP-1 drugs, exercise, rapamycin, spermidine, oxytocin, hormones, mitochondrial function, and other longevity interventions. This is essential listening for anyone interested in memory, sleep, Alzheimer’s prevention, brain aging, smell training, dementia, PTSD, autism, longevity, neuroplasticity, biohacking, and protecting cognitive function as you age. You’ll Learn: -Why your sense of smell often declines alongside memory -How smell connects directly to the brain’s memory and emotional centers -Why poor olfactory function is associated with Alzheimer’s risk and mortality -How chronic congestion may affect memory and brain health -What COVID-related smell loss may mean for long-term cognitive health -How olfactory enrichment can stimulate memory centers while you sleep -Why one study reported a 226% improvement in memory in healthy older adults -How scent exposure may increase deep sleep and reduce nightmares -Why novelty and rotating scents appear to matter for neuroplasticity -How smell training is being studied in dementia, depression, PTSD, and autism -Why several longevity interventions are also associated with improved olfaction -How GLP-1 drugs may affect smell, food enjoyment, memory, and emotion -Why professional wine tasters may offer clues about protecting the aging brain
Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.comDAVE and using code DAVE at checkout. - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Michael Leon, smell training, olfactory enrichment, sense of smell, memory improvement, brain aging, Alzheimer’s disease, dementia, deep sleep, nightmares, PTSD, autism, depression, COVID smell loss, olfactory system, neuroplasticity, MemoryAir, essential oils, cognitive decline, all-cause mortality, GLP-1, rapamycin, spermidine, oxytocin, longevity, brain health, sleep optimization, memory loss, olfactory stimulation
Resources: • Visit https://memoryair.com/ and use code DAVE15 for 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 — Smell and Your Brain 01:25 — Intro 06:52 — Why Smell Goes Unnoticed 10:59 — Making MemoryAir 15:46 — Smell and Dementia 20:00 — Smell Predicts Lifespan 25:32 — Testing Your Sense of Smell 28:33 — Autism and Olfactory Therapy 36:23 — Biohacking Your Nose 42:50 — GLP-1 and Olfaction 45:55 — PTSD, Nightmares, and Sleep See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537 | 16 sept. 2026 | 00:55:33 | |
**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!** At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools. The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance. This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity. You'll Learn:
Thank you to our sponsors! - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality Resources: • Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 – Trailer 01:15 – Intro 07:16 – Alcohol & Hangover Hacks 13:24 – Spirituality & Health 19:36 – Hormone Therapy for Women 24:45 – Inside Gatlan's Model 30:35 – Potty Training Secrets 38:39 – North Dakota & Fargo 43:57 – Hollywood's Beauty Secrets 50:19 – Acting Career & Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Peptide Secrets to a Youthful Face : 1536 | 15 sept. 2026 | 00:55:39 | |
Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. **For Dave’s listeners only, visit oneskin.co/Dave for exclusive early access to the OS-01 Face Rich Cream!** Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a co-inventor of five patents, and has co-authored numerous scientific publications. She and her team are studying skin longevity by targeting one of the central drivers of aging: the accumulation of senescent cells. They break down why skin loses its ability to hold water as you age, and why that process can accelerate dramatically during perimenopause and menopause. Carolina explains the skin's "brick and mortar" barrier system, how declining estrogen affects collagen, ceramides, cholesterol, hyaluronic acid, and elastin, and why simply sealing moisture into your skin with occlusive products does not solve the underlying biology. They also explore why GLP-1 users can experience loose or sagging skin after rapid weight loss and what may help preserve skin structure over time. Carolina reveals how her team screened hundreds of peptides to develop OS-01, a senomorphic peptide designed to reduce the damaging signals produced by senescent "zombie" cells while supporting healthier skin function. In their research, OS-01 reduced markers of cellular senescence and inflammation, increased collagen production, and was associated with a 2.5-year reduction in measured biological skin age. She also explains why more peptides are not necessarily better, why some GHK-Cu formulations may fail to perform, and why peptide stability, concentration, delivery, and formulation matter. The conversation also covers why the skin around your eyes may biologically age decades faster than your cheeks, whether topical collagen really works, why cholesterol is essential for a healthy skin barrier, how over-moisturizing and "slugging" can backfire, and how damaged skin may contribute to systemic inflammation. Carolina also shares clinical data on OneSkin's new OS-01 Rich moisturizer, including improvements in hydration, firmness, fine lines, wrinkles, collagen, hyaluronic acid, and elastin. This is essential listening for anyone serious about skin longevity, anti-aging, menopause, GLP-1 weight loss, collagen, senescent cells, peptides, biological age testing, inflammation, hydration, hair and skin health, and maintaining younger-looking skin as you age. You'll Learn: -Why menopause can rapidly accelerate dry, thin, and crepey skin -How your skin's natural barrier holds water and why it breaks down with age -Why GLP-1 weight loss can make loose and sagging skin more noticeable -How senescent "zombie" cells accelerate inflammation and collagen loss -How OS-01 was associated with a 2.5-year reduction in biological skin age -Why skin around your eyes may be biologically much older than skin on your cheeks -Why topical collagen is different from collagen amino acids and collagen-producing signals -How cholesterol, ceramides, fatty acids, and hyaluronic acid support skin hydration -Why some GHK-Cu peptide products may not perform as expected -How over-moisturizing, face masks, Vaseline, and "slugging" can disrupt the skin barrier -How scientists measure the biological age of skin with epigenetic clocks -Why healthier skin may help lower inflammation throughout the body
Thank you to our sponsors! - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Calroy | Go to calroy.com/dave for your discount. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Carolina Reis de Oliveira, OneSkin, OS-01, skin longevity, skin biological age, skin age reversal, senescent cells, zombie cells, menopause skin, perimenopause skin, GLP-1 weight loss, loose skin, crepey skin, skin hydration, skin barrier, collagen production, hyaluronic acid, elastin, ceramides, cholesterol skin, GHK-Cu, copper peptide, peptides, epigenetic skin clock, MoClock, fine lines, wrinkles, skin firmness, slugging, topical collagen Resources: • OneSkin | Get Early Access To OS-01 Rich Cream: oneskin.co/Dave • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 — Trailer 01:33 — Meet Carolina & OneSkin 04:31 — Skin Hydration Decline 11:46 — How the Peptide Hydrates Skin 18:20 — Zombie Cells Explained 23:32 — Discovering Peptide OS-01 32:44 — Measuring Biological Skin Age 39:00 — Skincare Philosophy for Men 43:32 — Body Lotion & Inflammation 50:09 — New Rich Cream Data See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| What 36 Hours Without Sugar Does to Your Body : 1535 | 13 sept. 2026 | 00:12:05 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video walks you through the complete biological timeline of a 36-hour sugar fast, from insulin dropping and liver glycogen draining to fat burning, ketone production, lower inflammation, and sharper mental clarity. You’ll see how quickly your metabolism can start switching back to the fuel system it was built to use. Thank you to our sponsors!
00:00 – Sugar's Deadly Toll 01:31 – Insulin's Hidden Damage 02:52 – The Glycogen Reserve 04:12 – Liver Fuel Runs Low 05:29 – Reversing Insulin Resistance 07:30 – Brain's Fuel Problem 07:53 – Ketones: Backup Fuel 09:24 – The Hormonal Reset 10:46 – Visible Physical Changes Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534 | 11 sept. 2026 | 00:09:48 | |
Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased signaling tied to neurite growth and synapse development, with treated mice even growing thicker, darker, glossier hair. Plasmalogens are specialized lipids concentrated in cell membranes and the brain that tend to decline with age and neurodegenerative disease, making them an intriguing target for cognitive longevity. Host Dave Asprey breaks down why membrane composition matters for brain signaling, mitochondrial function, and inflammation, while stressing that this remains mouse research from 2022 and does not mean eating sea squirts or taking an unproven plasmalogen supplement will reproduce the same effects in humans. Sources: https://www.sciencedaily.com/releases/2026/09/260902234518.htm https://doi.org/10.3389/fmolb.2022.815320 ~~ Apple Watch Series 12 Adds More HRV Data, Readiness Scoring, And Health Age Apple Watch Series 12 pushes deeper into health tracking with heart rate measurements every five seconds, substantially more frequent HRV sampling, a new daily Readiness score, and a Longevity section in the Health app featuring Health Age. Apple is also expanding its health ecosystem with daytime vitals, movement assessments, menopause tracking, and Quest Diagnostics lab ordering for more than fifty biomarkers. Host Dave Asprey explains why higher-frequency wearable data can become useful for spotting changes in stress, recovery, sleep, and illness, but warns against letting algorithmic scores override your own baseline, symptoms, and real-world performance. Source: ~~ FDA Moves To Accelerate Botanical Drug Development The FDA has opened a formal request for input on how to accelerate botanical drug development, including better clinical trial designs, stronger quality standards, improved standardization of complex plant mixtures, and expanded use of real-world evidence. The agency is also working with the European Medicines Agency on regulatory considerations for herbal and botanical medicines, potentially creating a clearer path for standardized plant-derived therapies to move beyond vague supplement claims and into more rigorous clinical testing. Host Dave Asprey breaks down why this could strengthen the evidence behind compounds like berberine, saffron, medicinal mushrooms, and flavanols, while also warning that more pharmaceutical-style regulation could increase costs and reduce access. Source: https://www.healthmanagement.com/insights/weekly-roundup-v2/september-9-2026/ ~~ Persistent Adolescent Cannabis Use Linked To Long-Term IQ And Cognitive Decline A long-running New Zealand birth cohort found that people with persistent cannabis dependence beginning in adolescence showed significant cognitive decline by age thirty-eight, including losses in IQ, memory, processing speed, attention, and executive function. The most persistent users showed an average decline of roughly eight IQ points, while adult-onset users did not show the same pattern, pointing toward adolescence as a potentially important developmental vulnerability window. Host Dave Asprey explains why this 2012 observational study cannot prove cannabis caused every cognitive change, but argues that dose, frequency, age of exposure, and brain development all matter when evaluating cannabis for performance, health, or therapeutic use. Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC3479587/ ~~ Pterostilbene Helps Mouse Muscle Cells Burn More Fat Through PPAR-Delta Researchers testing pterostilbene, a polyphenol found in blueberries and grapes, found that it reduced intracellular fat accumulation and increased fatty acid oxidation in cultured mouse muscle cells. Rather than directly activating PPAR-delta, pterostilbene appeared to slow its breakdown, leaving more of the protein available to regulate genes involved in fat metabolism and potentially offering a new mechanistic target for myosteatosis and metabolic dysfunction. Host Dave Asprey explains why the PPAR-delta mechanism is interesting for metabolic health, but draws a clear line between promising cell research and human outcomes, emphasizing that resistance training, walking, muscle mass, and mitochondrial health still have far stronger evidence than taking blueberry extracts to reduce muscle fat. Sources: https://www.sciencedaily.com/releases/2026/09/260903064219.htm https://doi.org/10.1016/j.fbio.2026.109519 https://www.reddit.com/r/Biohackers/comments/1w8flq4/compound_in_blueberries_may_help_muscle_cells/ ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want emerging research on brain aging, wearables, botanical medicine, cannabis, metabolic health, and supplements translated into what matters for human biology. Host Dave Asprey separates promising mechanisms from premature hype and explains how to evaluate new health research through the lens of evidence quality, dose, biological context, and measurable outcomes. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: plasmalogens aging, plasmalogens brain health, sea squirt plasmalogens, cognitive longevity, neuroinflammation, synaptic health, Apple Watch Series 12, Apple Watch HRV, Apple Watch Readiness score, Apple Health Age, biological age tracking, wearable health data, Quest Diagnostics Apple Health, FDA botanical drugs, botanical medicine regulation, standardized botanical extracts, berberine research, medicinal mushrooms, cannabis IQ decline, adolescent cannabis brain development, cannabis cognitive decline, marijuana memory, pterostilbene fat metabolism, pterostilbene PPAR delta, blueberries metabolism, intramuscular fat, myosteatosis, metabolic flexibility, longevity news 2026, biohacking news 2026 Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:24 – Sea Squirt Anti-Aging Lipids 01:39 – Apple Watch Series 12 03:38 – FDA Botanical Drug Push 05:25 – Cannabis & Brain Health 06:47 – Blueberry Fat Metabolism 08:33 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533 | 08 sept. 2026 | 01:09:00 | |
Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has built a following of over 12 million people by making gut science accessible and actionable. He has spent his career removing colon cancers, treating digestive disease, and now studies how gut bacteria drive nearly every system in the body, from hormone metabolism to brain optimization. They break down why fibermaxxing can backfire without the right mix of fast, medium, and slow fermenting fibers, and why generic "eat more fiber" advice ignores what your gut bacteria actually need. The conversation covers protein absorption limits and how much your body can really use, the truth about saturated fat and metabolism, and why the sodium-to-potassium ratio matters more than sodium alone. They also dig into fasting and the gut's natural cleaning cycle, the estrobolome and testobolome and their role in hormone balance and longevity, and how AI is starting to reshape personalized health data, supplements, and functional medicine. Dr. Rajan shares some of the strangest objects he has surgically removed from patients, and explains what your poop's color, shape, and consistency reveal about liver function, inflammation, and disease risk long before symptoms show up anywhere else. This is essential listening for anyone serious about biohacking, gut health, human performance, longevity, mitochondria function, nootropics, ketosis, carnivore and fiber-based diets, sleep optimization, anti-aging, and hacking your metabolism from the inside out. You'll Learn:
Thank you to our sponsors! - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Karan Rajan, gut surgeon, fibermaxxing, gut microbiome, Bristol stool chart, poop health, Throne, fermentation geography, soluble fiber, insoluble fiber, prebiotics, inulin, oxalates, estrobolome, testobolome, migrating motor complex, sodium potassium ratio, saturated fat, ghee, collagen, protein absorption, keto, carnivore, fasting, gut bacteria, flatulence science
Resources: • Dr. Karan's Newsletter: https://drkaran.kit.com • Learn more about Throne - https://www.thronescience.com/ • Check Out Dr. Karan’s YouTube: https://www.youtube.com/c/DrKaran • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 – Trailer 00:55 – Meet Dr. Karan Rajan 04:04 – Kellogg's History & Farts 11:53 – Throne Poop Tracking 19:35 – Poop Colors & Wild Stories 28:02 – Worst Foods & Saturated Fat 36:26 – Fiber Fermentation Geography 46:57 – Sodium & Salt Myths 59:03 – Keto, Carnivore & Fasting 01:04:45 – AI, Misinformation & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532 | 06 sept. 2026 | 00:10:03 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey Most people fail to lose weight because they have a metabolic block nobody told them about. In this video, I’ve shared the three golden rules for losing 50 pounds fast, and why everything you've been told about weight loss is working directly against you. You'll also learn:
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00:00 – Intro 00:24 – The Metabolic Block 02:21 – Rule 1: Cut Processed Food 03:46 – Rule 2: Fasting Matters 05:29 – Two Types of Hunger 06:34 – How Fasting Works 07:11 – Rule 3: Environment Design 08:32 – Redesign Your Kitchen Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531 | 04 sept. 2026 | 00:07:48 | |
Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol and better insulin sensitivity to cleared acne, eliminated brain fog, and colds cured within 24 hours. The biochemistry behind the trend is real: garlic contains no allicin until it's crushed or chopped, which mixes an enzyme with a sulfur compound to form the active compound, and letting it sit for ten to fifteen minutes before cooking preserves more of that activity. Host Dave Asprey separates what the human data actually supports, modest blood pressure and cholesterol effects, real antimicrobial properties, and a genuine bleeding-risk caution for anyone on blood thinners, from the unproven parasite-cleanse and brain fog claims driving the trend online, drawing on his own EEG tracking to challenge the cognitive benefit narrative directly. Sources: https://nypost.com/2026/09/01/health/is-garlic-the-ultimate-biohack/ https://holisticheartcenters.com/new-cholesterol-guidelines-2026/ ~~ HEPA Air Filtration Linked To Measurable Brain Function Improvements In One Month A new study found that older adults using true HEPA filtration to reduce indoor fine particulate matter saw small but measurable cognitive improvements after just one month, adding to a growing body of evidence connecting air pollution exposure to neuroinflammation and long-term cognitive decline. Host Dave Asprey breaks down why clean air belongs in the biohacking conversation alongside supplements and training protocols, and why the World Health Organization's decision to list air pollution as a modifiable dementia risk factor is a bigger deal than it sounds. Sources: https://www.sciencedaily.com/releases/2026/08/260830000016.htm ~~ Egg Yolk-Derived Peptides Show Neuroprotective Effects Against Oxidative Stress New research on phosphopeptides isolated from egg yolk phosvitin found that the compounds reduced reactive oxygen species, improved antioxidant defense markers, and increased neuron survival in cells exposed to oxidative stress in the lab. Host Dave Asprey connects this early but promising finding to his long-standing case for the whole egg, yolk included, as one of the most nutrient-dense foods available, and flags what would need to happen next for this to translate into a usable protocol. Source: ~~ Heat Stroke Survivors Face Elevated Cardiovascular Risk Years Later, Research Shows A closer look at heat stroke recovery reveals it's rarely a one-day event. Survivors of classic heat stroke had three and a half times the rate of ischemic heart disease twelve years later compared to matched controls, along with elevated long-term risk of kidney disease and lingering heat intolerance, fatigue, and dizziness. Host Dave Asprey draws the line between the controlled heat stress he uses deliberately in sauna and hyperthermic conditioning and the uncontrolled, uncooled heat exposure that leaves this kind of lasting cardiovascular damage, and what that distinction means for how to think about any stressor. Source: ~~ Long-Term Melatonin Use Linked To Nearly Double Heart Failure Risk In Large Cohort Study A cohort study of over 130,000 adults with chronic insomnia found that those who used melatonin for a year or more had nearly double the rate of heart failure and all-cause mortality compared to non-users, along with a three and a half times higher rate of heart failure hospitalization. Host Dave Asprey walks through why this is observational data, not proof of causation, and why he's stayed a low-dose, occasional melatonin user for years rather than a nightly one, plus what the real underlying driver of chronic insomnia might be for listeners still relying on it every night. Source: https://www.sciencedaily.com/releases/2026/08/260829035228.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest research on nutrition, air quality, brain health, heat stress, and sleep translated into what actually matters for your biology right now. Host Dave Asprey connects viral trends, clinical data, and decades of context into practical frameworks for taking control of your own health decisions. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: raw garlic biohack, allicin formation, garlic blood pressure, aged garlic extract, garlic cholesterol, HEPA air purifier brain health, PM2.5 cognitive decline, air pollution dementia risk, egg yolk phosvitin peptides, oxidative stress neuroprotection, egg yolk nutrition, heat stroke cardiovascular risk, heat stroke recovery, hyperthermic conditioning, sauna protocol, melatonin heart failure risk, chronic insomnia, sleep hygiene, circadian rhythm, biohacking news 2026 Thank you to our sponsors!
Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Garlic & Brain Fog 02:06 – HEPA Filtration & Cognition 03:20 – Egg Yolk Peptides 04:16 – Heat Stroke 05:22 – Melatonin 06:54 - Wrapup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530 | 03 sept. 2026 | 01:58:16 | |
Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know Back with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook to reverse all three. Want to try Jenny's makeup and skincare line? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount. Host Dave Asprey sits down with Jenny McCarthy Wahlberg, a New York Times bestselling author, actress, comedian, and 14-season judge on The Masked Singer who became one of the most trusted voices in the autism community after her son's regression following a vaccine reaction. She documented his recovery in books including Louder Than Words and Healing and Preventing Autism, founded the vegan, cruelty-free beauty brand Formless Beauty, and now develops unscripted television, documentaries, and podcasts with her husband Donnie Wahlberg through their Work Baby Productions banner under a first look deal with Lionsgate. Dave and Jenny trace her son's autism diagnosis back to a vaccine reaction and walk through the biohacking protocol that helped him recover, including candida detox, activated charcoal binders, collagen and hypermobility support, and hacking his gut with a low toxin diet that removed wheat and dairy. They connect autism to mitochondria energy collapse and neuroinflammation, and explain how nootropics like modafinil restore focus without the crash of stimulants. The conversation moves into longevity and human performance strategies for adults, covering low dose Cialis for brain blood flow, DHEA and thyroid optimization for women over 35, peptide protocols including melanotan and Retatrutide, cyclical ketosis and fasting alternatives, and why hormone replacement therapy reverses aging instead of causing cancer. They dig into functional medicine tools for everyday life: electrolytes and salt for blood pressure and sleep optimization, blackout darkness for circadian repair, baking soda for metabolism and alkaline balance, and why Jenny trusts krill oil over fish oil for anti-aging support. Dave breaks down ibogaine and neuroplasticity for brain repair, defends his carnivore leaning diet, shares why Danger Coffee still starts his morning, and calls out AI chatbots for pushing censored health narratives. This is essential listening for anyone interested in biohacking, human performance, longevity, functional medicine, brain optimization, and building a smarter, not harder approach to supplements and long-term health. You'll Learn:
Thank you to our sponsors! - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jenny McCarthy Wahlberg, autism recovery, vaccine injury, biohacking, longevity, mitochondria, neuroinflammation, candida detox, mold toxicity, activated charcoal, hypermobility, collagen, modafinil, nootropics, human performance, hormone replacement therapy, DHEA, peptides, melanotan, ketosis, fasting, functional medicine, Danger Coffee, Smarter Not Harder, Dave Asprey, anti-aging, sleep optimization, brain optimization, metabolism, carnivore, ibogaine, neuroplasticity, supplements, PANS PANDAS Resources: • Want To Try Jenny's Makeup And Skincare Sine? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount. • Check Out Formless Beauty On YouTube: https://www.youtube.com/@formlessbeauty • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps: 00:00 – Trailer 01:20 – The Human Upgrade Starts 07:13 – Detoxing Candida: The Turnaround 15:00 – The Anti-Vaxxer Backlash 23:02 – The Many Flavors of Autism 29:36 – Powering Up the Autistic Brain 35:59 – The Bile & Binder Protocol 43:53 – Intuition, Trust & Integrity 53:40 – Building an Ethical Beauty Brand 58:34 – Sensory Sensitivities & Clean Living 01:04:00 – Modafinil: The Focus Drug 01:13:45 – Mold Illness, Memory & Brain Health 01:18:26 – Jenny McCarthy's Show Starts 01:22:45 – Dave's Mold Poisoning Story 01:31:04 – Nicotine, Ibogaine & Biohacking Extremes 01:38:33 – When Biohacking Goes Too Far 01:45:07 – Peptides, Hormones & Anti-Aging Hacks 01:52:24 – Hormone Replacement Therapy for Women See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| 3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529 | 01 sept. 2026 | 00:35:54 | |
The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering
Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system. Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing. This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork. You'll Learn:
Thank you to our sponsors! - ALP | Go to alppouch.com, code DAVE for 10% off. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - Visit www.myvitalc.com/davesfav to unlock Dave’s discount Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com
Timestamps: 00:00 – Trailer 01:01 – Intro 03:48 – Metformin 09:18 – Rapamycin 12:55 – Statins 17:28 – Statins & CoQ10 19:38 – Tadalafil 23:43 – SGLT2 Inhibitors 26:12 – Acarbose 28:40 – Low-Dose Naltrexone (LDN) 31:44 – Dosing & Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| 7 Brain Compounds I Take For Superhuman Focus : 1528 | 30 août 2026 | 00:09:43 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey The most powerful energy compounds aren't in your local supplement store. They're sitting in Eastern European science, and Thai herbal medicine, completely ignored by an industry that only profits from what it can patent. In this video I break down 7 compounds that have transformed my energy, sharpened my focus, and kept my brain performing like it did decades ago. You'll also learn:
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00:00 – Intro 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Change Your Morning, Change Your Life! Hal Elrod : 1527 | 28 août 2026 | 01:13:33 | |
Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to! Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives. On today’s episode, Hal tells us all about his updated version of The Miracle Morning. He explains SAVERS, the six foundational practices that will transform your morning and change your life. We also talk about tips for hacking your sleep, productivity, and relationships. Hal shares the stories of his devastating car accident and rare cancer diagnosis—and the superpowers he gained from coming back to life. We explore how these near-death experiences changed his perspective on life and what he values most. He also tackles some tough questions… Should we try to help everyone? What does it mean to be a “man”? And what does it take to truly serve others? There’s so much to take away from Hal’s refreshing and optimistic perspective. (00:03:20) Creative Ways To Hold Yourself Accountable (00:13:57) Ditching Veganism (00:21:08) Hal’s Near-Death Experiences (00:27:35) Taking Your Health in Your Hands (00:29:37) Did Hal Come Back With Superpowers? (00:31:55) Are You Supposed To Help Everyone? (00:40:51) How the Miracle Morning Changed Hal’s LIfe (00:43:42) What Does It Mean To Be a “Man”? (00:51:25) Customizing Your Morning To Meet Your Needs (00:54:05) The Six Savers for Success (00:56:53) Tips To Save Your Sleep (01:01:51) The MVP of Personal Development Practices (01:06:14) Nourishing Our Connections Sponsors -Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. -The One Device | Use code DAVE for $10 off at theonedevice.com/dave -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: The Miracle Morning and The Miracle Equation Website: halelrod.com Facebook: Hal Elrod X: @HalElrod YouTube: @HalElrod See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Learn THIS And You’ll Become Impossible To Trigger : 1526 | 27 août 2026 | 01:01:46 | |
Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads
Your nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you the exact framework for building real nervous system mastery instead of running on autopilot until it fails. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jonny Miller, host of the Inner Frontier Podcast and founder of Nervous System Mastery, who has taught more than 1,000 people how to build the skills of interoception, self-regulation, and emotional fluidity. A former Silicon Valley founder turned nervous system expert, Jonny brings a rare mix of rational, data-driven thinking and deep somatic work to a field most high performers avoid entirely. They break down why interoception, self-regulation, and emotional fluidity are the three learnable skills behind every major shift in performance, relationships, and decision-making, and why most high achievers have spent their whole lives disconnected from what's happening below the neck. Jonny introduces the half-life of reactivity, his framework for measuring how quickly someone can move from triggered back to calm, and explains how free diving became his gateway into surrender, breath work, and pressure equalization as a form of high-stakes meditation. Dave shares his own parallel journey through nervous system work, including lessons from running 40 Years of Zen and a costly business betrayal that reshaped how he reads people. Dave and Jonny also open up about grief, including Jonny's experience losing his fiancée and later his mother, and how community and co-regulation shape how fast someone actually heals. You'll Learn:
Thank you to our sponsors! - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jonny Miller, Inner Frontier Podcast, Nervous System Mastery, interoception, self-regulation, emotional fluidity, half-life of reactivity, free diving, breathwork, nervous system regulation, somatic healing, grief processing, co-regulation, congruence, trauma response, boundary setting, narcissism, hiring intuition, cold plunge, surrender, NSDR, yoga nidra, Breath Buddy, biohacking, high performance, 40 Years of Zen, psychedelic integration, Silicon Valley founder, emotional resilience Resources: • Nervous System Mastery Course: https://www.nsmastery.com/ • Listen To Jonny’s Podcast ‘The Inner Frontier’ at: https://open.spotify.com/show/1lGD5wIfhnE4bepja42C9S • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:10 – Losing His Fiancée 04:28 – Nervous System Mastery 11:52 – Community & Co-Regulation 17:37 – From Head to Body 22:52 – Surrender & Free Diving 28:54 – Half-Life of Reactivity 35:33 – Congruence & the $100M Lesson 38:58 – Stupidity, Narcissism & Intuition 50:22 – Biohacking Trojan Horses 59:11 – Breath Buddy & Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525 | 25 août 2026 | 01:01:59 | |
Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial Intelligence
Your brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to use artificial intelligence as a tool for brain optimization instead of a crutch that erodes your memory, focus, and critical thinking. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jim Kwik, one of the world's leading experts in memory improvement, brain optimization, and accelerated learning. For more than 30 years, Jim has served as the brain coach to professional athletes, political leaders, business magnates, and Hollywood icons, with corporate clients including Google, Nike, SpaceX, and Harvard. He hosts the Kwik Brain podcast with over 100 million downloads, reaches 200,000 people annually through live keynotes, and just wrapped his 14th annual Beyond Biohacking Conference with 5,000 attendees in Austin. Jim overcame a childhood brain injury that left him labeled "learning disabled," and turned that struggle into a mission he calls "no brain left behind." They break down the MIT study showing that people who use AI to write and think score worse on memory and comprehension than those who rely on their own brains, and why that matters for anyone serious about longevity, human performance, and anti-aging. Jim introduces the concept of digital dementia and cognitive sovereignty, explaining how nootropics, neuroplasticity, and functional medicine can support your biology while AI still requires you to keep your own hardware sharp. They cover the MEDS Rx framework for brain optimization: meditation, exercise, diet, sleep optimization, and relationships, plus why mitochondria, metabolism, and inflammation from processed food directly impact your cognitive output. Jim also shares how his own kids use AI as a tutor rather than a replacement for thinking, and why sleep inertia and the first few minutes after waking set the tone for your entire day. This is essential listening for anyone serious about biohacking, hacking their own brain, longevity, neuroplasticity, brain optimization, supplements, and building a Smarter Not Harder approach to human performance in the age of AI. You'll Learn:
Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. - LMNT | Check it out at drinklmnt.com/DAVE. You'll get a free 8 count sample pack with any purchase. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jim Kwik, Limitless, Kwik Brain, digital dementia, cognitive sovereignty, human intelligence, artificial intelligence, MIT AI study, brain injury recovery, accelerated learning, memory improvement, speed reading, neuroplasticity, spaced repetition, memory palace, MEDS Rx framework, sleep inertia, attentional priming, metacognition, digital deduction, brain optimization, cognitive flexibility, cognitive anti-fragility, 40 Years of Zen, biohacking, Beyond Biohacking Conference, HUMAN framework, learning how to learn, GPS dependency, mental fatigue, burnout recovery, Limitless Daily Resources: • Learn More About Jim At: https://limitlessdaily.com/ • Follow Jim On Instagram At: https://www.instagram.com/jimkwik/ • Watch Jim On YouTube At: https://www.youtube.com/jimkwik • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:55 – Intro 06:54 – AI as Tool, Not Crutch 13:00 – Protecting Cognitive Sovereignty 21:28 – Digital Dementia Explained 27:13 – AI-Enhanced Learning Techniques 32:18 – Speed Listening and Reading 40:38 – Rapid Tips by Age 46:59 – Building an AI Second Brain 53:04 – Burnout and Brain Optimization See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Most Important Longevity Molecule I've Ever Found : 1524 | 23 août 2026 | 00:14:42 | |
Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey Most people see the physical decline of aging as an inevitable process that can only be managed with medications, but this video cuts through that assumption by explaining that the smartest minds in science, including multiple Nobel Prize winners, have identified a single root cause of aging tied to a specific molecule called NAD+. You'll also learn:
Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors!
Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523 | 21 août 2026 | 00:35:32 | |
This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles. Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels. I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode. Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you. Thank you to our sponsors! -Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Sri Sri Ravi Shankar, Dave Asprey, Art of Living, Sudarshan Kriya, breathwork, pranayama, meditation, non-dual consciousness, gut feeling intuition, biohacking, quantum physics consciousness, Nobel Prize physics, curiosity and childlike wonder, skepticism vs cynicism, scientific temper, dogmatism, veterans PTSD breathwork, SKY campus happiness program, violence prevention, community building, dating apps romance, Elon Musk Mars, computer chip brain implant, duality and consciousness, equanimity, ego and inner voice, spirituality and science, yoga philosophy, guru interview, positive energy radiation, transcending fear
Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com
Timestamps: 00:00 - Trailer 01:11 - Curiosity & Skepticism 03:42 - Reality, Physics & Illusion 06:34 - Non-Dual Consciousness 08:37 - Origins of Breathwork 13:36 - Trusting Your Gut Feeling 14:28 - Violence, Peace & Veterans 19:54 - Romance & Dating Apps 23:44 - Science Behind Meditation 27:27 - Fear of the Unknown See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Wild New Theory of Cancer (It's GOOD For You?) : 1522 | 20 août 2026 | 01:03:07 | |
Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload
Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous? Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel computing hardware for AI applications. Previously a Staff Scientist at Los Alamos National Lab, Coles led their near-term quantum computing group and made significant contributions to quantum computing theory. He holds a Ph.D. in Chemical Engineering from UC Berkeley and a Master of Philosophy in Biochemistry from Cambridge, and he's currently developing a new theory for cancer and chronic disease, the subject of this conversation. His rare combination of hard physics and deep biochemistry gives him a radically different lens on one of medicine's most misunderstood diseases. Coles lays out his Toxin Sequestration Theory, a framework that reframes cancer tumors not as malignant accidents but as intentional storage vaults the body builds to sequester toxins, heavy metals, seed oils, mold, and excess glucose, away from healthy tissue and mitochondria. He and Dave connect the dots between this theory and chronic disease, biohacking fundamentals, and why chemotherapy itself behaves as a toxin that can backfire. They dig into oxalates, deuterium, linoleic acid, circadian biology, and the detox protocols that support the body's natural ability to shrink these toxic reservoirs. This conversation challenges the mainstream genetic theory of cancer, explores the metabolic theory popularized by Thomas Seyfried, and lands on a radical, functional medicine-aligned framework for anyone serious about longevity, anti-aging, and human performance. Dave and Coles also break down how sleep optimization, fasting, ketosis, and a carnivore approach to nutrition support the body's detox hierarchy, from fat tissue and the liver to moles, cysts, and eventually tumors themselves. This is essential listening for anyone serious about biohacking, functional medicine, mitochondria health, brain optimization, nootropics, and taking full control of their metabolism and longevity. You'll Learn:
Thank you to our sponsors! - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: toxin sequestration theory, cancer theory, Patrick Coles, quantum computing scientist, thermodynamic computing, Normal Computing, Los Alamos National Lab, chemotherapy toxicity, oxalates cancer, deuterium toxin, Stephanie Seneff, heavy metal detox, mycotoxins tumors, seed oils cancer, linoleic acid, oleic acid oxidation, lipid peroxidation, glucose toxicity, mitochondria downregulation, genetic theory of cancer, metabolic theory of cancer, Thomas Seyfried, spontaneous tumor regression, backup detox organ, circadian rhythm cancer, mold toxins, forever chemicals, microplastics, bile flow, activated charcoal binders, cholestyramine
Resources: • Follow Patrick’s Work At: https://www.instagram.com/patrickc_tst/ • Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com
Timestamps: 00:00 – Trailer 00:58 – Introducing Patrick Coles 04:08 – Toxin Sequestration Theory 06:26 – Defining a Toxin 14:13 – Cancer as Backup Detox Organ 15:01 – History of the Theory 16:30 – Deuterium and Oxalates 21:31 – Cancer Theories Compared 28:06 – Chemotherapy and Toxic Overload 37:23 – Tiered Toxin Storage System 45:17 – Diet, Light, and Circadian Rhythm 50:39 – Detox Protocols and Binders See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521 | 18 août 2026 | 02:46:40 | |
Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview Episode
Mega-Episode time! Your hormones might be causing symptoms you've been blaming on aging, stress, or your heart. This double interview episode gives you a real look at biohacking from two different angles: cutting-edge longevity science and the lived experience of hormone optimization after 50.
Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Gabby Reece, an American athletic icon, wellness entrepreneur, and one of the most influential voices in women's health, fitness, and performance. A former professional beach volleyball player who became Nike's first female spokesperson and shoe designer, Gabby set volleyball records at Florida State University that still stand today, and her signature Nike shoe line famously outsold Air Jordan during its release. She has since built a career at the intersection of performance and longevity, co-founding Hamilton House, Laird Superfood (NYSE: LSF), XPT, and HIGHX, and hosting both The Gabby Reece Show and the Proof of Practice podcast alongside leading voices in women's health and evidence-based performance. She is also a New York Times bestselling author. In this episode, Gabby turns the tables and interviews Dave herself, creating a rare two-way conversation between two people deeply immersed in human performance and biohacking. Dave and Gabby dig into how mitochondria function as quantum systems that shape everything from cognitive performance to spiritual perception, why autism can come with genuine neurological superpowers, and what actually happens in the body when hormone levels shift after 40. Gabby shares her personal protocol, including weekly testosterone injections, an estradiol patch, and a compounded hormone cream that most people have never heard of, and explains how correcting her hormones, not her thyroid, resolved a heart arrhythmia doctors initially missed. The conversation also covers Dave's approach to cancer protocols, why he avoids GLP-1 drugs despite their longevity benefits, the peptides he actually uses for mitochondrial renewal, and how cyclical ketosis, fasting, and a carnivore-leaning diet fit into a sustainable performance strategy. They also talk about AI's growing role in personalized longevity research, sleep optimization while traveling, and the supplement and functional medicine protocols Dave relies on daily. You'll Learn:
Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Visit www.myvitalc.com/davesfav to unlock Dave’s discount - Fatty15 | You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone therapy, hormone replacement therapy, HRT for women, weekly testosterone injections, scream cream, compounded testosterone cream, vasodilation, AFib hormones, heart arrhythmia, menopause symptoms, thyroid vs testosterone, mitochondria quantum biology, biohacking, Dave Asprey, autism superpowers, cancer protocols, serrapeptase, nattokinase, peptides longevity, cyclical ketosis, carnivore diet, Gabby Reece, longevity for women, anti-aging hormones Resources: • Learn More About The Hamilton House At: https://hamiltonhouse.co/ • Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:52 – Gabby Interviews Dave 02:58 – Fatherhood and Teenagers 12:25 – Autism and Superpowers 17:02 – Quantum Biology & Biohacking 24:03 – Autism Epidemic and Hope 35:01 – Joe Rogan Feud 48:04 – Death, Immortality, Living to 180 56:24 – The Four F's Framework 1:04:55 – Cancer Prevention and Detection 1:18:20 – Travel Biohacking Tips 1:31:46 – Nothing You Can't Hack 1:41:23 – Peptides Deep Dive 1:52:33 – The Human Upgrade Podcast Starts 1:59:35 – Advice at Eighteen 2:10:03 – Fame and Holding Back 2:22:44 – Hormone Replacement Therapy 2:31:31 – Pursuit Over Happiness 2:43:02 – Advice for Tall Women See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| It's Weird, But It Turns On Your Anti-Aging Switch : 1520 | 16 août 2026 | 00:15:10 | |
Save Up To $600: SUNLIGHTEN.COM/DAVE Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:
Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors!
Timestamps: 00:00 – The Longevity Switch 00:59 – Mitochondria: Power Plants 02:14 – What Is Mitophagy 04:05 – How Stress Blocks It 05:36 – Exercise Extremes 07:29 – NAD+ and Silent Damage 08:59 – Reversing It: Fasting 10:27 – REHIT and Cold Exposure 12:02 – The Supplement Stack Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519 | 14 août 2026 | 00:10:54 | |
PhenoNet Cleared By FDA To Begin Phase 3 Trial Of Inhaled Alzheimer's Drug PhenoNet has received FDA clearance to begin a Phase 3 trial of PHENOGENE-1A, an inhaled formulation of cromolyn sodium, an asthma drug with decades of safety data. Unlike most Alzheimer's therapies, which target only APOE4 gene carriers, this ~648-person trial stratifies both carriers and non-carriers by genotype, testing whether reducing amyloid aggregation, inflammation, and microglial dysfunction can benefit a broader Alzheimer's population than current treatments reach. Host Dave Asprey explains why this genotype-inclusive design challenges the field's narrow focus on APOE4 carriers, and what it means for families with Alzheimer's history who don't carry the gene. Sources:
~~~ University Of Zurich Researchers Discover The Adult Brain Can Repair Itself Better Than Believed Researchers at the University of Zurich identified a population of "regenerative astrocytes" in living mouse brains that repair damaged tissue through a previously unknown mechanism: dividing cells send newly formed nuclei traveling across long cellular extensions to repopulate injured regions and rebuild the astrocyte network. The discovery overturns the long-standing assumption that adult brains have limited capacity to replace lost astrocytes after injury or autoimmune disease. Host Dave Asprey unpacks why this finding reframes brain injury recovery as something the body may already be equipped to handle, and what the newly identified genetic pathways could mean for future regenerative therapies. Sources:
~~~ Sheep's Wool-Derived Keratin Outperforms Collagen In Bone Regeneration Study Researchers at King's College London developed a keratin scaffold from sheep's wool, a farming industry waste product, and tested it against collagen, the current gold standard, in rats with non-healing skull defects. While collagen produced more total bone volume, the keratin scaffold generated bone that was more structurally organized and closer to natural bone architecture, while remaining stable and integrating cleanly with surrounding tissue. Host Dave Asprey explains why bone quality, not just quantity, matters for weight-bearing repair, and why a cheaper, more sustainable material outperforming the standard is a bigger deal than it sounds. Sources:
~~~ Oral GLP-1 Pill Aleniglipron Shows 12% Weight Loss In Phase 2b Trial Structure Therapeutics' oral small-molecule GLP-1 receptor agonist, aleniglipron, produced up to 12.1% weight loss at 36 weeks in a 230-person Phase 2b trial, with no apparent plateau and continued loss to 16% in the open-label extension, putting an oral pill in the same efficacy range as injectable GLP-1 drugs like Wegovy and Ozempic. Host Dave Asprey weighs the compliance advantage of an oral option against his ongoing concerns about muscle loss, rebound weight gain, and the fact that GLP-1 drugs treat a symptom rather than the underlying metabolic cause. Sources:
~~~ Study Finds 150 Minutes Of Weekly Exercise Falls Far Short Of Real Heart Protection A Macao Polytechnic University analysis of over 17,000 UK Biobank participants found that the standard 150-minute weekly exercise guideline only reduces cardiovascular risk by 8-9%, while achieving a substantial risk reduction of over 30% requires 560-610 minutes a week, three to four times current recommendations. Only 12% of participants hit that higher threshold. Host Dave Asprey breaks down why public health minimums are a floor, not an optimization target, and what listeners serious about cardiovascular protection should actually be aiming for. Sources:
~~~ New Research Clarifies The Mechanism Behind IV Vitamin C's Anti-Cancer Effect Decades after Linus Pauling's high-dose vitamin C claims were dismissed following failed oral-dose trials, researchers have clarified that Pauling had the mechanism right and the delivery method wrong: IV vitamin C bypasses gut absorption limits to reach plasma concentrations up to 100 times higher than oral dosing, generating hydrogen peroxide that is selectively toxic to cancer cells due to their lower catalase levels. A 2024 University of Iowa study found IV vitamin C combined with chemotherapy doubled overall survival in advanced pancreatic cancer patients. Host Dave Asprey reflects on how this vindicates a decades-old idea that was dismissed for the wrong reasons, and what it means for anyone facing a cancer diagnosis. Sources:
This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest breakthroughs in neurodegenerative disease, regenerative medicine, metabolic health, and cancer therapeutics, translated into what actually matters for your biology right now. Host Dave Asprey connects clinical trial data, mechanistic research, and decades of context into practical frameworks for taking control of your own health decisions. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: PhenoNet PHENOGENE-1A, inhaled cromolyn Alzheimer's, APOE4 genotype Alzheimer's trial, regenerative astrocytes brain repair, University of Zurich brain regeneration, adult neuroplasticity, keratin bone scaffold, sheep's wool regenerative medicine, collagen vs keratin bone repair, aleniglipron oral GLP-1, Structure Therapeutics weight loss drug, oral semaglutide alternative, exercise minutes cardiovascular risk, 150 minutes exercise guideline, Macao Polytechnic University heart study, IV vitamin C cancer, Linus Pauling vitamin C, ascorbate hydrogen peroxide cancer cells, integrative oncology, biohacking news 2026, Thank you to our sponsors! - Visit www.myvitalc.com/davesfav to unlock Dave’s discount - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Alzheimer's Drug Trial 01:43 – Brain Repair Cells 03:07 – Keratin Bone Scaffolds 04:45 – Oral GLP-1 Pill 05:59 – Minimum Effective Exercise 07:26 – IV Vitamin C Revisited 08:12 – Vitamin C Cancer Trial 09:30 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Dave Solo Pod: The Original Smart Drug Masterclass : 1518 | 13 août 2026 | 00:41:29 | |
Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive Decline
We're excited to bring you another Dave solo education masterclass, this one breaking down the molecule that started the entire nootropics industry: Racetams Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey pulls back the curtain on piracetam and the racetam family, the original nootropics that quietly built the foundation for modern human performance and brain optimization. As the father of biohacking and someone who has taken racetams almost every single day for 25 years, Dave brings firsthand experience most experts simply don't have. He built two Bulletproof-era companies and led the biohacking movement while running this stack daily, and in this episode, he shares exactly how it worked for him. Dave traces the strange 1964 Belgian lab discovery that forced scientists to invent the word "nootropic" in the first place, then breaks down how these compounds shift acetylcholine, glutamate, and AMPA signaling to improve memory, focus, and neuroplasticity without touching dopamine or spiking your heart rate. He covers the mitochondria and membrane fluidity mechanisms behind the anti-aging and longevity effects, walks through dosing for all five major racetams, and explains who actually benefits versus who's wasting their money. This is essential listening for anyone serious about biohacking, human performance, functional medicine, and brain optimization. Whether you're stacking supplements for sleep optimization, exploring fasting and ketosis for metabolism, or just trying to think clearer without sacrificing your health, this episode hands you a real framework for hacking cognitive decline before it starts. You'll Learn:
Thank you to our sponsors! - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: piracetam, racetam, nootropics, smart drugs, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, cognitive enhancement, brain optimization, memory improvement, neuroplasticity, mitochondrial function, acetylcholine, glutamate AMPA receptors, choline supplements, CDP-choline citicoline, alpha-GPC, brain fog remedy, stroke recovery cognitive, dementia prevention, biohacking supplements, Dave Asprey nootropics, longevity brain health, focus and concentration, memory recall, cognitive decline aging
Resources: • Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:10 – Intro 04:30 – Birth of the Nootropic 08:55 – How Racetams Work 12:51 – Membranes & Blood Flow 15:55 – Piracetam: The Original 19:30 – Aniracetam & Others 22:00 – Phenylpiracetam Power 26:37 – Who Benefits & Stacking 32:25 – Safety & Regulation 36:41 – Starter Protocol & Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life : 1517 | 11 août 2026 | 01:11:13 | |
UFOs, UAPs, Non-Human Contact & Zero-Point Energy: Dr. Steven Greer on Government Disclosure, Consciousness and the Truth About Extraterrestrial Intelligence
Get ready to have your entire understanding of reality challenged. This episode reveals the science behind non-human intelligence contact, the physics of consciousness, and why the biggest secret in human history could rewrite everything you know about energy, medicine, and human potential. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Steven Greer, a retired emergency physician and founder of the Center for the Study of Extraterrestrial Intelligence. For over 35 years, Dr. Greer has briefed CIA directors, Pentagon officials, and members of Congress on UFO disclosure, built an archive of more than 750 whistleblower testimonies, and pioneered the CE5 Contact protocol used to initiate peaceful contact with non-human craft. His firsthand experiences, government-level access, and decades of documented research make him one of the most credible voices in the disclosure movement. Dr. Greer and Dave dive into the science of consciousness as a nonlocal field, the zero-point energy technology he believes has been suppressed for 70 years, and how mastering this "hacking" of physics could eliminate scarcity, extend human longevity, and unlock forms of neuroplasticity and human performance most people have never considered. They explore near-death experiences, precognitive dreams, remote viewing, and the idea that a small percentage of people practicing deep meditative states can shift collective consciousness at scale. The conversation also touches on how corruption, fear, and disinformation have kept transformative technology out of public hands, and what it would take for humanity to responsibly manage a disclosure that changes everything. This is essential listening for anyone into biohacking, human performance, consciousness exploration, longevity, functional medicine, and understanding how the mind and unseen fields of energy shape human potential. You'll Learn:
Thank you to our sponsors! - Qualia | Go to qualialife.com/ASPREY for 50% off, and use code ASPREY for an additional 15% off. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Steven Greer, Steven Greer UFO, CE5 Contact protocol, Disclosure Project, UFO disclosure 2026, UAP disclosure government, zero point energy technology, anti-gravity technology suppressed, Roswell crash truth, non-human intelligence contact, extraterrestrial biological entity, remote viewing training, nonlocal consciousness field, Maharishi effect meditation, near-death experience consciousness, Dave Asprey Steven Greer, military industrial complex UFO, Eisenhower alien meeting, whistleblower testimony UFO, consciousness and quantum entanglement
Resources: • Learn More About Dr. Greer’s Work At: http://drstevengreer.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 — Trailer 01:02 — Intro 02:29 — Evidence & Whistleblowers 08:30 — Free Energy Suppression 12:52 — The Suppressed Tech 20:46 — Who Controls the Cover-Up 28:44 — Roswell & ET History 35:26 — Fake UFOs & Disinformation 39:00 — Threats, Bribes & Going Public 41:46 — Consciousness & CE5 50:13 — Greer's Personal Contact 01:05:20 — Free Energy Entrepreneurship See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| 300mg Improves Appearance of Wrinkles In 7 Days (Study) : 1516 | 09 août 2026 | 00:13:32 | |
This video reveals how your skin uses glutathione to defend itself, how Dr. Nayan Patel solved its delivery problem, and why his topical antioxidant serum was clinically shown to improve the appearance of fine lines, wrinkles, and skin tone in just 1 week. You’ll also learn:
Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors!
Timestamps: 00:00 - Intro 00:19 - Anti-Aging Drug Screening 01:43 - Protein Restriction & Aging 03:36 - New Skin Injectable 05:23 - Arts & Longevity 07:30 - Biohacking Interventions Reviewed 08:51 - Semaglutide & Aging Clocks 09:29 - Closing Takeaways Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more... : 1515 | 07 août 2026 | 00:10:33 | |
Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle Nasal Spray Ingredient Emerges As Unexpected Longevity Candidate In Massive Drug Screen Researchers mapped 2,358 longevity-associated genes across the body's broader protein and signaling networks, then screened 6,442 approved drugs to see which ones nudged those aging pathways in a healthier direction. Oxymetazoline, the active ingredient in nasal sprays like Afrin, was among 21 standout candidates, with a predicted pathway running through the ACKR3 receptor and connecting to major aging proteins including NF-kB, TP53, and AKT1. Host Dave Asprey explains why this computational screen is a promising research lead rather than a protocol, and why chronic use of a vasoconstricting nasal spray carries real risks regardless of what a network analysis suggests. Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC12425021/ ~~ New Review Of 350+ Studies Asks Whether Less Protein Means Longer Life A review spanning more than 350 studies found that protein restriction consistently extended lifespan and improved metabolic health across mice, rats, flies, and fish, with smaller human studies showing improvements in body fat and fasting glucose even when total calorie intake rose. Researchers point to FGF21, a liver hormone that rises under protein or amino acid scarcity and boosts energy expenditure and glucose regulation, as a key mechanism. Host Dave Asprey breaks down why blanket protein advice fails older adults preserving muscle and highly active people just as badly as it fails everyone else, and why matching intake to actual biology beats maximizing protein at every meal. Sources: https://time.com/article/2026/08/03/eat-less-protein-age-better-live-longer/ https://www.sciencedaily.com/releases/2026/08/260801042811.htm https://www.cell.com/cell-reports-blue/fulltext/S2949-8821(26)00079-9 https://pmc.ncbi.nlm.nih.gov/articles/PMC8991228/ https://www.eurekalert.org/news-releases/1137190 ~~ Processed Cadaver Skin Injectable Enters The Anti-Aging Market As Elravie Re2O A new injectable called Elravie Re2O, short for "return to your 20s," is made from donated human skin processed to remove living cells and most genetic material, leaving a collagen-rich extracellular matrix that gets injected into the face and neck as a biological scaffold rather than a simple filler. Human-derived tissue matrices already have a track record in burn and wound care, but this specific product is not yet FDA-approved and lacks comparative trial data against existing fillers. Host Dave Asprey separates legitimate regenerative medicine from a novel cosmetic product still waiting on long-term safety and consistency data. Sources: https://nypost.com/2026/07/21/health/the-hottest-new-anti-aging-treatment-cadaver-skin/ https://www.newsobserver.com/living/article316698211.html https://www.miamiherald.com/living/article316698295.html https://pmc.ncbi.nlm.nih.gov/articles/PMC12985180/ https://laboderm-skin.com/elravie-re2o-application/ ~~ UCL Study Finds Weekly Arts Engagement Tracks With Slower Epigenetic Aging A University College London study of more than 3,500 adults found that people who engaged weekly with arts and culture, including painting, music, museums, and theater, showed a roughly four percent slower pace of aging on the DunedinPACE clock and appeared about one biological year younger on PhenoAge, with the effect holding after adjusting for income, education, smoking, and physical activity. Benefits appeared whether people were actively creating art or simply attending performances and exhibits. Host Dave Asprey argues this expands what counts as a health input beyond molecules and devices, since novelty, meaning, and social connection influence the nervous system too. Sources: https://www.npr.org/2026/05/12/nx-s1-5818172/study-arts-slow-biological-aging https://studyfinds.com/arts-culture-may-slow-aging/ ~~ Review Of 41 Human Studies Ranks Which Interventions Actually Shift Epigenetic Clocks A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, semaglutide, pitavastatin, and ketamine, while nicotinamide riboside, rapamycin, and senolytics showed no detected clock improvement in the studies reviewed. Semaglutide produced the strongest single result, slowing DunedinPACE by about nine percent in a trial of adults with HIV-associated fat redistribution, though a separate fatty liver study produced mixed outcomes. Host Dave Asprey explains why a strong mechanistic story does not guarantee a moved biomarker, and why clinical outcomes, functional measures, and safety data all matter alongside any single clock reading. Sources: https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1836446/full https://pubmed.ncbi.nlm.nih.gov/42294499/ https://www.nature.com/articles/s41514-026-00383-9 https://pmc.ncbi.nlm.nih.gov/articles/PMC12338914/ https://medicalxpress.com/news/2026-06-popular-glp-drug-biological-aging.html https://www.creativebiomart.net/blog/semaglutide-may-slow-epigenetic-aging-in-humans https://www.aging-us.com/article/202913/text https://superpower.com/guides/can-you-reverse-epigenetic-age https://www.nature.com/articles/d41586-026-01836-7 https://www.businessinsider.com/first-ever-reverse-aging-drug-was-just-injected-into-a-human-2026-6 ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into a computational drug-repurposing screen, the case for eating less protein, a new regenerative injectable made from human tissue, the biological effect of creative engagement, and a data-driven ranking of which longevity interventions actually move epigenetic clocks. Host Dave Asprey connects computational biology, nutrition science, regenerative medicine, and biomarker research into practical frameworks for evaluating what belongs in a real longevity protocol versus what belongs on a watch list. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oxymetazoline longevity, drug repurposing screen aging, ACKR3 receptor aging pathway, protein restriction longevity, FGF21 hormone aging, low protein diet healthspan, cadaver skin injectable, Elravie Re2O, extracellular matrix regenerative medicine, anti-aging injectable 2026, arts engagement biological age, DunedinPACE epigenetic clock, PhenoAge biological age, epigenetic clock interventions, semaglutide epigenetic aging, rapamycin epigenetic clock, senolytics human trials, biological age testing, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Anti-Aging Drug Screening 01:43 – Protein Restriction & Aging 03:36 – New Skin Injectable 05:23 – Arts & Longevity 07:30 – Biohacking Interventions Reviewed 08:51 – Semaglutide & Aging Clocks 09:29 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Here's How You Can Have a 3-hour Orgasm (real!) : 1514 | 06 août 2026 | 01:00:43 | |
The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena)
Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your hormones, and your longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Regena Thomashauer, known worldwide as Mama Gena, founder and CEO of the School of Womanly Arts and a New York Times bestselling author. For over three decades she has taught hundreds of thousands of women how to reclaim pleasure as a source of power, and her work has redefined what modern feminism and embodiment look like in practice. Dave and Regena break down the actual biology behind orgasm: the oxytocin, prolactin, and endorphin cascade that shifts the body out of fight or flight and into repair, the role of sleep optimization in processing trauma, and how chronic disconnection from pleasure keeps people stuck in survival mode instead of human performance mode. They dig into semen retention research and its link to longevity and anti-aging, why shame around the body blocks neuroplasticity and emotional healing, and how learning to regulate arousal, rage, and surrender is its own form of nervous system hacking. This is a masterclass in reclaiming a part of your biology most people were never taught to understand, let alone optimize. This is essential listening for anyone serious about biohacking, human performance, brain optimization, functional medicine, longevity, and building a body and mind that can hold more pleasure, more power, and more presence. You'll Learn:
Thank you to our sponsors! - ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask. - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Mama Gena, Regena Thomashauer, On Our Knees book, Pussy A Reclamation, School of Womanly Arts, orgasm and oxytocin, prolactin endorphins orgasm, extended orgasm training, semen retention benefits, Daoist orgasm practices, Lafayette Morehouse, truth tantrum tender tantrum, clitoris anatomy explained, vulva versus vagina, goddess archetypes women, embodiment practice trauma, devotion versus attention, Dave Asprey Mama Gena, female pleasure biohacking, nervous system relaxation orgasm
Resources: • Order Regena’s New Book On Our Knee’s and visit her website at: https://mamagenas.com/books/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com
Timestamps: 00:00 – Trailer 01:21 –Intro 07:24 – Orgasm saved my life 16:34 – The body's medicine cabinet 20:08 – Meaning of On Our Knees 27:34 – Betrayal and forgiveness 37:05 – Righteous anger vs. stridence 47:02 – Semen retention practice 52:51 – Energetic heart connection 01:00:53 – Daoist orgasm equations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513 | 04 août 2026 | 01:12:44 | |
The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek Lal Your lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic inflammation, and slow aging, and gives you a science-backed way to biohack your breath from the inside out. Get A generous discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’
Host Dave Asprey sits down with Dr. Vivek Lal, MD, FAAP, a double board-certified physician scientist who discovered the gut-lung axis while running the Pulmonary Microbiome Lab at the University of Alabama at Birmingham. He serves as Director of Clinical Innovation at UAB's Marnix Heersink Institute of Biomedical Innovation and trained in pulmonary and vascular biology at UT Southwestern before completing MIT's executive program in drug and device development. As a serial entrepreneur through his venture studio Biostack Ventures, he founded and now serves as CEO of Resbiotic Nutrition, and also launched Alveolus Bio, an FDA-track pulmonary drug development company. His decade of research turned into the world's first probiotic built specifically for respiratory health. Dave and Vivek break down MMP-9, the overlooked inflammatory pathway that drives collagen breakdown, chronic lung disease, and accelerated aging throughout the body. They cover why germ-free mice outperform normal mice, how antibiotics and toxic mold reshape your lung bacteria for years, why breathwork actually changes your lung microbiome, and how postbiotics and inhaled probiotics could become the next frontier in functional medicine. Along the way they get into supplement formulation, drug development red tape, and why self-experimentation should be treated as a right, not a privilege. You'll Learn:
Thank you to our sponsors! - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. - Calroy | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: gut-lung axis, lung microbiome, MMP-9 inflammation pathway, Resbiotic review, does Resbiotic work, Resbiotic lung support, Dr. Vivek Lal, gut-lung axis probiotic, lung microbiome science, MMP-9 longevity pathway, MMP-9 collagen breakdown, best probiotic for lung health, probiotics for asthma, probiotics for allergies, inhaled probiotics FDA, postbiotics for inflammation, NLRP3 inflammasome, NF-kappa B pathway, breathwork lung microbiome, toxic mold lung bacteria, antibiotics lung damage, biohacking respiratory health, lung microbiome 2026, resbiotic.com discount code DAVE20, functional medicine for lungs, quit vaping lung health
Resources: • Get a discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Cold Open 01:08 – Intro 05:17 – Discovering the Lung Microbiome 16:58 – Antibiotics' Effect on Lungs 20:30 – MMP-9 Explained 25:56 – NLRP3 & the Inflammasome 31:36 – The Right to Self-Experiment 42:04 – Lung Training 1:00:18 – Astronaut Microbiomes 1:12:33 – Closing & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| I Wish I Knew This Anti-Aging Hack Sooner : 1512 | 02 août 2026 | 00:13:54 | |
There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older. In this video, I explain why glutathione is known as the body’s master antioxidant and why it plays a critical role in cellular defense, mitochondrial energy, immune regulation, and liver detoxification. You’ll discover why aging is not just your body “wearing out,” but the slow breakdown of your internal repair and antioxidant defense systems. You’ll also learn: -Why oxidative stress damages mitochondria and accelerates aging -How glutathione helps protect cells from daily stress -Why your liver uses huge amounts of glutathione for detox support -The difference between oral, liposomal, IV, and topical glutathione -Why delivery matters if you want your body to actually use it -How to stack glutathione with sleep, protein, sunlight, training, and sauna Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors!
00:00 – Intro: The Anti-Aging Molecule 02:59 – The Vicious Decline Cycle 04:15 – Step 1: Lower Oxidative Load 05:00 – Step 2: Support Mitochondria 05:41 – Introducing Glutathione 08:54 – Oral & Liposomal Glutathione 10:02 – IV Glutathione 10:17 – Topical/Transdermal Delivery 11:23 – The Glutaryl Solution 12:47 – Daily Routine & Final Thoughts Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Chicken Diarrhea, TV Kills You Quicker, CO2 for Health, Deadly Hot Neighborhoods, and more... : 1511 | 31 juil. 2026 | 00:08:49 | |
Viagra's Cancer Signal, TV's Toll on Your Brain, Heat and Accelerated Aging, and a New Way to Flush Your Brain Explained Viagra's Active Ingredient May Block Cancer From Spreading A study published in Cancer Research from the Weizmann Institute of Science, in collaboration with Clalit and the U.S. National Cancer Institute, found that sildenafil, the active ingredient in Viagra, may interfere with cancer cells' ability to metastasize by disrupting how they regulate cholesterol, a resource tumors need to detach and invade new tissue. The team combined mouse models and human cell cultures with more than twenty years of medical records covering roughly five million people, and found better survival outcomes among about forty thousand cancer patients who had taken sildenafil before diagnosis. Researchers also flagged a possible combination effect with statins. Host Dave Asprey breaks down why this cheap, off-patent drug class deserves more attention than it's getting, and where it fits alongside his own longevity protocol. Source: https://www.healthline.com/health-news/viagra-may-stop-cancer-from-spreading-study ~~ Heavy TV Watching In Midlife Tied To Alzheimer's-Related Brain Changes A nearly twenty-four-year study published in Alzheimer's & Dementia followed more than 1,700 adults, tracking TV habits in their early fifties and scanning their brains in their mid-seventies. Men who watched more TV showed greater white matter damage and smaller frontal and occipital lobes, while women showed no such association. Critically, people with desk jobs that kept them sedentary all day did not show the same brain changes, and the TV association held even after adjusting for exercise levels. Host Dave Asprey unpacks why passive screen time, not sitting itself, may be the real driver here. Sources: https://www.the-independent.com/life-style/tv-time-linked-alzheimers-study-b3023054.html https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71582 ~~ Ambient Heat Exposure Linked To Faster Biological Aging A Science Advances study of 3,686 older adults linked neighborhood-level heat index exposure to accelerated biological aging using DNA methylation clocks. Short-term heat exposure moved one clock significantly, while exposure sustained over a full year or six years moved all major clocks, with extreme-caution heat days tied to nearly a three-year jump in one aging measure and a five percent faster overall aging pace on another. Researchers point to inflammation and stress signaling as likely drivers. Host Dave Asprey explains why this is a fundamentally different kind of heat story than the sauna and cold-plunge conversation biohackers are used to. Source: https://www.science.org/doi/10.1126/sciadv.adr0616 ~~ Industrial Chicken Farming May Be Accelerating The Spread Of Drug-Resistant Bacteria A genomic analysis of nearly 2,800 bacterial samples from chickens and wild birds across thirty countries, published in PNAS and covered by The Guardian, found a roughly hundredfold increase in Campylobacter strain transitions between wild birds and farmed chickens since 1900. Global chicken populations have grown sevenfold since the 1960s to about 27 billion birds, and researchers identified genetic adaptations tied to antimicrobial resistance developing inside that population. Sixty to eighty percent of human Campylobacter infections trace back to raw chicken, with links to post-infectious IBS in some cases. Host Dave Asprey connects the dots between industrial farming density and the gut-health stakes for anyone who eats chicken. Sources: https://doi.org/10.1073/pnas.2609969123 ~~ VA Researchers Develop Breathing-Based "Brain Flush" For Parkinson's And Alzheimer's VA researchers led by Dr. Henry Lin found a way to trigger the brain's glymphatic clearance system, normally active during deep sleep, in people who are awake, using alternating puffs of five percent carbon dioxide and room air every thirty-five seconds. In a study of thirty Parkinson's patients and thirty-three healthy controls, a single thirty-minute session produced measurable increases in blood levels of beta-amyloid, alpha-synuclein, and other waste proteins associated with neurodegeneration. The VA's Technology Transfer Program is now developing a patent and prototype device. Host Dave Asprey explains why this gives breathwork protocols a real physiological mechanism instead of just a hunch. Source: ~~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into an overlooked cancer drug repurposing story, the real difference between passive and active screen time, a new angle on heat as a biological stressor, the hidden gut-health cost of industrial poultry farming, and a breathing technique that may unlock your brain's own detox system. Host Dave Asprey connects clinical research, large-scale genomic data, and translational neuroscience into practical frameworks for improving longevity, gut health, and brain performance. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sildenafil cancer metastasis, Viagra cancer research, cholesterol cancer cells, PDE5 inhibitor longevity, TV Alzheimer's risk, screen time dementia, white matter brain aging, passive sedentary behavior brain, ambient heat epigenetic aging, DNA methylation clock, heat index biological aging, industrial chicken farming bacteria, Campylobacter antibiotic resistance, foodborne illness IBS, glymphatic system brain flush, CO2 breathing brain detox, Parkinson's Alzheimer's treatment, VA brain research, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Story #1: Viagra & Cancer 02:01 – Story #2: TV Watching & Brain Aging 03:16 – Story #3: Heat Exposure & Biological Age 04:46 – Story #4: Chicken Farming 06:34 – Story #5: CO2 Therapy & Brain Detox See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The $18 Million Pills Nobody Can Explain | Igniton : 1510 | 30 juil. 2026 | 00:55:24 | |
Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and Longevity
There's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes inside the lasers, vacuum chambers, and cold plasma behind the new science of quantum-charged supplements. Get 15% off your next purchase at: igniton.com/dave Host Dave Asprey sits down with Ashley Grace, an executive working directly with Igniton, the company behind a new category of supplements charged with particles pulled from the surface of the sun.
Dave and Ashley dig into the science and the story behind Igniton: an $18 million private lab built to recreate solar conditions here on Earth, peer-reviewed studies showing major gains in memory, attention, and sleep, and the strange psychological and even bordering-on-supernatural shifts users report after months on the product. They also get into coherence, cellular entropy, and why some of the biggest breakthroughs in human performance and longevity may come from fields and frequencies rather than another pill. This episode is essential listening for anyone into biohacking, nootropics, sleep optimization, brain optimization, and the cutting edge of anti-aging and functional medicine. You'll Learn:
Thank you to our sponsors! - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Igniton supplement review, subatomic particle supplement, quantum charged supplements, does Igniton work, Igniton sleep formula REM, Igniton cognition supplement, Jirka Rysavy Gaia, holoton NASA chair, cold plasma supplement technology, charged hydrogen bioavailability, Igniton clinical study results, Igniton vs placebo study, best nootropic for focus 2026, supplements for REM sleep, quantum technology longevity, Igniton.com discount code, Ashley Grace Charlotte's Web, coherence and cellular aging, energy healing biohacking, intuition and meditation supplements Resources: • Get 15% off your next purchase at: igniton.com/dave • Visit https://igniton.com to learn more about their processes and offerings • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:32 – Show Intro 06:15 – What Are Ignitons? 13:29 – How Ignitons Are Made 17:31 – Coherence & Longevity 22:18 – Water Molecule Charging 26:25 – Sleep Formula & REM Results 32:02 – Yogic Siddhis & Superpowers 38:43 – Dave's Amplified Abilities 43:31 – Energy Healing 46:22 – Consciousness Scale & Muscle Testing 51:08 – Discount Code Offer 55:12 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem : 1509 | 28 juil. 2026 | 00:58:19 | |
Urologist Dr. Alex Tatum on Girth Enhancement, Testosterone, and Peptide Therapy Most men will never ask their doctor the questions this episode answers. From safe, non-surgical girth enhancement to daily testosterone dosing to the peptides fighting for FDA access right now, this conversation covers what actually works, what's dangerous, and what your doctor probably won't bring up first.
Host Dave Asprey sits down with Dr. Alex Tatem, a board-certified urologist with fellowship training in male sexual and reproductive medicine. Dr. Tatem has built his practice and his YouTube following around pushing medicine beyond what the traditional medical establishment allows, with a focus on male girth enhancement, performance enhancement, peptides, and PEDs. They break down the real science behind penis enhancement, including why length surgery still does not exist, how hyaluronic acid injections safely increase girth, and why silicone and PMMA fillers have left men permanently disfigured. Dave and Dr. Tatem also get into cutting-edge testosterone dosing strategies, the peptides driving the biggest gains in human performance and longevity, including BPC-157, TB-500, SS-31, and MOTS-c, and why PT-141 has become the most talked-about peptide for libido and sexual health. You'll Learn:
Thank you to our sponsors! - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: penis girth enhancement hyaluronic acid, penis enlargement that actually works, average penis size urologist, PT-141 for libido, melanotan II peptide, BPC-157 benefits, TB-500 for injury recovery, SS-31 dosing, MOTS-c peptide FDA, daily subQ testosterone dosing, oral testosterone undecanoate, TRT dosing protocols, Anavar for muscle recovery, silicone penile implant risks, PMMA filler complications, is penis enlargement surgery safe, hyaluronic acid girth injection cost, Dr. Alex Tatem urologist, peptides FDA regulation 2026 Resources: • Check Out Dr. Tatem’s Content At: https://www.youtube.com/@DrAlexTatem • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 03:10 – Penis Enhancement Intro 13:32 – Dangerous Enhancement Methods 22:49 – Girth Procedure Explained 29:56 – Why Demand Is Rising 32:09 – Peptides for Men 41:26 – TRT and Testosterone 50:35 – Peptide Regulation Fight See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Does This Sleep Fasting Hack Actually Cut Cortisol? : 1508 | 26 juil. 2026 | 00:10:21 | |
You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things? In this video, Dave Asprey explains a hidden biological process that controls whether your body stays in stress mode at night… or finally switches into deep recovery mode. He breaks down why so many people wake up exhausted, why cortisol stays elevated while you sleep, and why your body may never fully enter repair mode even if you’re technically asleep. You’ll learn how one overlooked habit affects your brain, metabolism, recovery, heart rate, and overnight repair systems, plus the surprising research that showed dramatic changes in sleep quality from a single adjustment. Once you understand this mechanism, you’ll never look at sleep the same way again. Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors!
00:00 – Trailer 00:53 – Sleep Environment Matters 03:44 – Red Light Bulbs 04:50 – Blackout Curtains 05:16 – Light-Blocking Glasses 07:16 – Morning Supplement Stack 07:41 – Creatine for the Brain 11:48 – MCT Oil Fuel 13:06 – Cellular Cleanup (Autophagy) 15:12 – Magnesium for Sleep 16:56 – Full Stack Recap 18:26 – Biohacking Is Accessibl Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Diet Soda Brain Aging, Hidden Heart Attack Risk, New Cholesterol Pill, Lettuce Recall, and more... : 1507 | 24 juil. 2026 | 00:12:11 | |
Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study A study tracking more than 12,700 adults (average age 52) over eight years found that people consuming the most artificial and low-calorie sweeteners, roughly 191 mg a day, about what's in a single can of diet soda, showed cognitive decline 62% faster than the lowest-intake group, equivalent to 1.6 extra years of brain aging, with memory hit hardest. Six of the seven sweeteners tested, including aspartame, saccharin, and acesulfame K, were linked to faster decline; tagatose was the lone exception. Researchers point to gut-microbiome disruption, altered glucose and insulin signaling, and possible direct neuronal effects as plausible mechanisms. Host Dave Asprey breaks down why a dose this small was enough to move the curve, why tagatose deserves more scrutiny before being called "safe," and where diet products' short-term weight-loss marketing conveniently ignores the long-term cost to your brain. Source: ~~ AI Analysis Of 1,722 Heart Scans Finds Muscle Quality Predicts Heart Attacks Independent Of Calcium Score Using data from the SCOT-HEART trial, a University of Edinburgh team ran an AI model against ten years of coronary CT angiogram scans, measuring skeletal muscle attenuation, a marker of myosteatosis, or fat infiltration into muscle tissue. Every 10-point increase in muscle density corresponded to a 31% lower heart attack risk and 39% lower all-cause mortality over the following decade, and critically, this held independent of coronary calcium score, the current gold-standard risk marker. The same low-density-muscle patients also showed higher lung attenuation, lower liver attenuation, and more torso fat volume, a pattern consistent with systemic insulin resistance rather than a muscle-specific issue. Host Dave Asprey unpacks why calcium score isn't capturing the full risk picture, why myosteatosis is really a readout of whole-body insulin sensitivity, and what he'd add to a routine workup on top of a calcium score. Source: https://www.theguardian.com/science/2026/jun/30/strong-chest-back-less-likely-heart-attack-analysis ~~ FDA Approves First Oral PCSK9 Inhibitor, Cutting LDL By Up To 60% Without Injections Merck's enlicitide (brand name Lipfendra) is now FDA-approved as the first once-daily oral PCSK9 inhibitor, lowering LDL cholesterol by up to 60% in a phase 3 trial of 2,912 patients, routinely bringing levels down to 50-60 mg/dL. It works by blocking PCSK9, a liver protein that tags LDL receptors for destruction, the same target as injectable drugs like Repatha and Praluent, which have shown roughly 20% reductions in heart attacks and strokes in high-risk patients. Lipfendra is priced at $315 for a 30-day supply, with no excess side effects reported versus placebo over six months, though long-term outcome data is still pending. Host Dave Asprey explains why crushing total LDL without checking ApoB, LDL particle number, or oxidized LDL is optimizing the wrong variable, and what he'd want on his labs before considering a drug like this. Sources: https://www.cnbc.com/2026/07/16/mercks-cholesterol-pill-gets-us-fda-approval.html ~~ Cyclospora Outbreak Tied To Taylor Farms Lettuce Spreads To 34 States, Prompts Nationwide Recall Federal investigators have linked a multistate cyclosporiasis outbreak to shredded iceberg lettuce from Taylor Farms de Mexico, with Michigan alone logging over 5,000 cases and 100+ hospitalizations, much of it traced to lettuce used at Taco Bell. Taylor Farms has recalled all iceberg lettuce sourced from central Mexico, and Walmart has pulled Marketside Iceberg Salad and Marketside Shredded Lettuce with specific date codes across 27 states. Cyclospora spreads through fecal contamination and causes weeks of watery, explosive diarrhea if untreated; washing doesn't reliably eliminate it, since the parasite requires heat above 158°F to inactivate. Host Dave Asprey explains why pre-washed, pre-cut bagged greens remain a recurring contamination risk no matter what the label claims, and connects the outbreak's gut damage to lingering gut-brain consequences long after symptoms resolve. Sources: ~~ New Research Links Excessive Gut-Brain Synchronization To Anxiety And Depression Emerging research on the enteric nervous system, which contains over 100 million neurons and sends more signals to the brain than it receives, finds that when the gut's electrical rhythm synchronizes too tightly with the brain's, that over-coupling correlates with higher rates of anxiety and depression. The gut communicates with the brain through the vagus nerve, hormones, and immune signaling, and dysbiosis or ENS dysfunction has separately been linked to mood disorders in both human and animal studies. Host Dave Asprey breaks down why the goal isn't maximum gut-brain connection but the right kind of connection, questions whether the coupling is driving the anxiety or the anxiety is driving the coupling, and makes the case for treating mood from the gut up instead of the brain down. Source: https://refractor.io/medical/enteric-nervous-system-brain-link-mental-health/ ~~ Rhonda Patrick Explains Why She Never Adds Bananas To Her Berry Smoothies Rhonda Patrick has been telling audiences she skips bananas in her berry smoothies because of polyphenol oxidase, an enzyme in bananas that degrades the polyphenols in blueberries linked to improved cognition and vascular health, based on in-vitro and food chemistry data. She now builds her smoothies on an avocado base instead, and notes that vitamin C from citrus can partially inhibit the enzyme for anyone unwilling to drop the banana. Host Dave Asprey weighs in on the gap between lab chemistry and clinical outcome data, why that gap doesn't make the mechanism any less real, and why this is a low-cost swap worth making even without a human trial behind it. Sources: https://www.reddit.com/r/Biohackers/comments/1v2jbib/dr_rhonda_patrick_i_dont_add_bananas_to_my/ https://www.foundmyfitness.com/episodes/polyphenol-oxidase-bananas-smoothies ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insight into a sweetener risk hiding in everyday diet products, a heart attack predictor buried inside routine CT scans, the tradeoffs of a new cholesterol drug, a produce recall worth paying attention to, the science behind gut-driven anxiety, and a smoothie mistake that's quietly undercutting your polyphenol intake. Host Dave Asprey connects clinical research, cohort data, and food chemistry into practical frameworks for protecting brain health, cardiovascular health, and gut-brain resilience. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: artificial sweeteners cognitive decline, aspartame brain aging, tagatose safety, diet soda memory loss, myosteatosis coronary CT, skeletal muscle attenuation heart attack, SCOT-HEART trial, coronary calcium score insulin resistance, enlicitide Lipfendra FDA approval, oral PCSK9 inhibitor, LDL particle number ApoB, cyclospora outbreak 2026, Taylor Farms lettuce recall, cyclosporiasis symptoms treatment, enteric nervous system anxiety, gut brain synchronization, vagus nerve mental health, Rhonda Patrick polyphenol oxidase, banana blueberry smoothie mistake, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Story 1: Artificial Sweeteners 02:05 – Story 2: Muscle Fat & Heart Risk 04:36 – Story 3: PCSK9 Cholesterol Pill 06:27 – Story 4: Cyclospora Lettuce Outbreak 07:56 – Story 5; Gut-Brain Axis & Anxiety 09:29 – Story 6: Banana vs. Blueberry 11:08 – Predictions for Next 5 Years See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506 | 23 juil. 2026 | 01:07:30 | |
Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do.
Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription. Host Dave Asprey sits down with research microbiologist Kiran Krishnan, co-founder of Microbiome Labs, the leading microbiome therapeutics brand among healthcare professionals. He has published multiple peer-reviewed studies, holds global patents, and has spent 20 years building companies focused on the science of the microbiome. His work centers on spore-based probiotics, the rare strains proven to survive the stomach's brutal acidity and actually rebuild the gut from the inside out. Kiran and Dave break down why 98 percent of conventional probiotics die before they ever reach your gut, and why spore-forming bacteria are different. They dig into the "gelding effect," the well-documented pathway where endotoxins from bad gut bacteria shut down testosterone production and drive up cortisol, and how fixing your microbiome can reverse it. They cover the connection between endotoxemia and nearly every major marker of aging, metabolism, and inflammation, why butyrate acts like a natural GLP-1 for fat loss, how Akkermansia can upregulate mitochondria and improve blood sugar control, and the surprising role vitamin K2 plays in bone density and functional medicine. This is biohacking at the cellular level, using ancient biology, fasting-adjacent metabolic pathways, and precision supplementation to optimize human performance from the gut up. You'll Learn:
Keywords: best probiotics that survive stomach acid, spore based probiotics benefits, gelding effect testosterone, endotoxins and testosterone, how to lower endotoxins, LPS gut bacteria, Akkermansia GLP-1 natural, gut bacteria and belly fat, vitamin K2 bone density, Kiran Krishnan microbiologist, Just Thrive probiotic, leaky gut symptoms, microbiome and testosterone, fecal transplant benefits, Dave Asprey, biohacking, longevity Resources: • Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription • Learn More About All Of Just Thrive’s Offerings At: https://justthrivehealth.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Thank you to our sponsors! - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase. - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order. - Show notes - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com Timestamps: 00:00 – Trailer 00:38 – Kiran Intro 02:01 – Stomach Acid & Probiotics 05:25 – Fauci & Spore Bacteria 13:58 – Losing Gut Diversity 19:01 – How Butyrate Is Made 22:11 – Dave's Personal Stack 24:00 – Quorum Sensing 31:26 – Endotoxins Explained 37:13 – Charcoal & Binders 39:41 – SIBO & Gut Bacteria 45:03 – Discovering Vitamin K2 49:33 – Gelding Effect & Testosterone 54:51 – Akkermansia & Weight Loss 01:02:17 – Role of Bitters 01:04:47 – Just Thrive Gift See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Truth About Visceral Fat vs Subcutaneous Fat | Dr. Sean O’Mara : 1505 | 21 juil. 2026 | 01:00:58 | |
Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking your metabolism, heart, and longevity, and exactly what to do about the difference.
Get $300 off your next Prenuvo MRI scan: https://prenuvo.com/?discount=Dave Host Dave Asprey sits down with Dr. Sean O'Mara, a former undercover narcotics agent, criminal prosecutor, emergency medicine physician, and retired U.S. Army Colonel who assisted the White House and Senior Executive Service, treating Vice President Dick Cheney, former President Bill Clinton, and Secretary of State Colin Powell. Today he's recognized as the world's most experienced physician in eliminating visceral fat and epicardial adipose tissue (EAT), the inflammatory fat now linked to nearly every major chronic disease and accelerated aging. He founded Influence Medicine, a specialty built around helping senators, heads of state, and top executives optimize their biology so they can perform and lead at the highest level. Dave and Dr. O'Mara break down the real difference between visceral fat and subcutaneous fat, why a visible six-pack might signal hidden disease, and how MRI scans reveal what your mirror never will. They dig into the biohacking strategies that actually shift your body composition: fasting protocols that build beneficial fat instead of burning it away, microbiome optimization for fat metabolism, and the supplements and functional medicine tools Dr. O'Mara uses with his highest-performing clients. They also cover the gut-hormone connection driving modern metabolic dysfunction, why political leaders are quietly getting scanned, and what your face reveals about your visceral fat levels before you ever step on a scale. You'll Learn:
Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen. Order when you start a subscription. You save more than $26 - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: visceral fat vs subcutaneous fat, how to reduce visceral fat, best fat for longevity, MRI body scan benefits, Prenuvo full body scan, what is epicardial fat, skinny fat TOFI explained, why is my six pack unhealthy, 72 hour fasting benefits, fasting and testosterone, how to build subcutaneous fat, biohacking visceral fat, Sean O'Mara doctor, influence medicine, fecal microbiota transplant benefits, gut microbiome and fat loss, Dave Asprey, biohacking, longevity Resources: • Learn More About Dr. O’Mara’s Work At: https://drseanomara.com/ • Get $300 Off Your Next Prenuvo MRI Scan: https://prenuvo.com/?discount=Dave • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com
Timestamps: 00:00 – Trailer 00:58 – Intro 02:38 – Fat Type Basics 04:19 – Reviewing Dave's Scan 08:04 – Good Fat vs. Bad Fat 16:49 – Fertility & Pregnancy 19:47 – Personality & Health 21:51 – Wealth & Health Neglect 30:32 – Insurance Incentives 39:29 – Microbiome & Disease 40:41 – FDA & Fecal Transplants 42:57 – Viome & Biomarker Data 45:40 – Skinny Fat & Appearance 49:44 – Building Subcutaneous Fat 52:57 – Fasting Protocol 58:37 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| If I Only Had $200 to Reverse My Age... : 1504 | 19 juil. 2026 | 00:20:01 | |
Most people think biohacking is only for billionaires with access to expensive machines, private clinics, and million-dollar anti-aging protocols. But the truth is, some of the most powerful upgrades in your biology start with the basic signals your body receives every single day. In this video, Dave Asprey breaks down how to start biohacking with around $200 by focusing on the foundations that control your sleep, energy, focus, and cellular repair. These are the simple changes that can create a massive difference before you ever spend money on advanced technology. If you’ve ever wanted to feel sharper, recover better, sleep deeper, and support your body’s natural repair systems without wasting money on random gadgets, this video shows you where to start. Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors!
00:00 – Trailer 00:53 – Sleep Environment Matters 03:44 – Red Light Bulbs 04:50 – Blackout Curtains 05:16 – Light-Blocking Glasses 07:16 – Morning Supplement Stack 07:41 – Creatine for the Brain 11:48 – MCT Oil Fuel 13:06 – Cellular Cleanup (Autophagy) 15:12 – Magnesium for Sleep 16:56 – Full Stack Recap 18:26 – Biohacking Is Accessibl Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| The Science And Health Of Community Eating (How Many Times A Week?) : 1503 | 17 juil. 2026 | 01:17:20 | |
Shawn Stevenson On The Science of Family Meals, Oxytocin, and Longevity Your dinner table might be the most overlooked biohack in your house. This episode reveals the exact minimum dose of family meals that lowers a child's risk of obesity, the hormone your body releases every time you eat with people you love, and why teaching your kids to cook may protect their metabolism for life. Host Dave Asprey sits down with Shawn Stevenson, founder of The Model Health Show and author of the bestselling Eat Smarter Family Cookbook series. Shawn spent over two decades studying nutritional science and functional medicine after recovering from advanced degenerative disc disease at age 20, and he has become one of the most trusted voices in health media for turning peer-reviewed research into real-world family habits. Shawn and Dave break down the science of community eating, including new research on oxytocin, nervous system regulation, and metabolism that shows why sitting down together beats eating alone every time. They cover the four biological drives running your behavior, the connection between family culture and longevity, and how simple shifts like humming, breathwork, and intentional meals can support brain optimization and anti-aging at a cellular level. This conversation also dives into the five love languages hidden inside food, a bio-photon DNA experiment that reframes how energy moves between people, and the exact number of meals per week that changes a child's health trajectory. You'll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Keywords: Shawn Stevenson, Dave Asprey, The Human Upgrade, biohacking, family dinner, family meals, community eating, longevity, functional medicine, oxytocin, nervous system regulation, childhood obesity, teaching kids to cook, five love languages, Model Health Show, Eat Smarter Family Cookbook, brain optimization, anti-aging, metabolism, nutrition science, mental health, family culture, healthy habits, minimum effective dose, human performance Thank you to our sponsors! -Gatlan | Book your free consultation at www.gatlan.com/DAVE -Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Here's Why Your Supplements Don't Seem To Work | Nayan Patel : 1502 | 16 juil. 2026 | 00:58:33 | |
Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything) Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there. Use code DAVE for a discount at aurowellness.com/dave Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking. Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects. You'll Learn:
Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com and using code DAVE at checkout Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine Resources: • Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave • Learn More About Dr. Patel’s work at: http://aurowellness.com/dave • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:43 – Episode Intro 03:16 – Glutathione Basics 07:34 – Senescent Cells 11:07 – Cellular Delivery Science 14:20 – GlyNAC Precursors 21:37 – Amino Acid Ratios 25:18 – GHK Copper Peptide 28:41 – Purity & Manufacturing 31:34 – Glutathione vs. NAD 33:49 – Absorption Studies 37:51 – Heavy Metals & Toxins 42:35 – Alcohol & Glutathione 47:43 – Mortality & Reincarnation 49:54 – GLP-1s & Anhedonia 53:25 – Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| Peter McCullough: Spike Protein Detected 3.6 Years After the Shot (Detox Protocol) : 1501 | 14 juil. 2026 | 01:27:32 | |
Cardiologist Dr. Peter McCullough on mRNA Persistence, Nattokinase, and the Fight Over COVID-19 Treatment" Six years after standing before the US Senate and calling out the pandemic response in real time, Dr. Peter McCullough returns with new evidence on where the spike protein came from, how long it persists in the body after infection or vaccination, and what's being done to break it down. This episode traces the science from a 2015 gain-of-function paper to a patient still showing circulating spike protein 3.6 years after vaccination. Get Dr. McCullough's free spike protein guide: myfreespikeguide.com Host Dave Asprey sits down with Dr. Peter McCullough, a physician trained in internal medicine, cardiology, and epidemiology, and one of the most published and most censored voices of the COVID-19 pandemic. He authored the first multi-drug treatment protocol for COVID-19, testified before the US Senate in 2020 and again in 2025, and has published extensively in the peer-reviewed literature on vaccine safety, spike protein biology, and early treatment. His book Courage to Face COVID-19 and his most recent New York Times bestseller, Vaccines, Mythology, Ideology and Reality, examine the history and science behind vaccine policy. Dave and Dr. McCullough trace the origins of the spike protein back to 2015 and 2016 research papers describing a lab-created, SARS-like coronavirus explicitly labeled "poised for human emergence," and discuss the funding, institutions, and researchers involved. They break down why synthetic mRNA vaccines resist the body's normal RNA breakdown process, what a patient case revealed about spike protein circulating 3.6 years after vaccination, and how nattokinase, a natural enzyme, has shown the ability to break the spike protein down. They also cover the suppression campaigns against ivermectin and hydroxychloroquine, the wartime propaganda origins of terms like "misinformation" and "anti-vaxxer," and what Dr. McCullough says he would do differently if he ran HHS. The conversation closes with new research on cognitive superagers, the small percentage of people who reach 100 with intact memory and health. You'll Learn:
Thank you to our sponsors! - TrueDark | Visit truedark.com and use code DAVEASPREY15 (discount applies to all frames except Aegis) - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Qualia | Go to qualialife.com/ASPREY for 50% off, and use code ASPREY for an additional 15% off. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: spike protein detox, how long does spike protein last in your body, nattokinase spike protein, mRNA vaccine side effects, is the spike protein still in my blood, gain of function research explained, where did COVID come from, Wuhan lab leak evidence, ivermectin banned, why was hydroxychloroquine banned, vaccine injury compensation act, mRNA vaccine shedding, spike protein detox protocol, how to live to 100, cognitive superagers, Peter McCullough, Dave Asprey Resources: • Learn More About Dr. McCullough’s Work At: https://www.twc.health/pages/focal-points • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:43 – Intro 02:10 – 2020 Public Health Failures 05:07 – Vaccine History & Mythology 07:19 – Vaccine Hesitancy as Disease 13:12 – Masks & Lockdown Absurdity 18:03 – War on Hydroxychloroquine 23:56 – Ivermectin Suppression 28:58 – FTC Misinformation Crackdown 31:18 – Propaganda Terms Explained 39:55 – McCullough's Confidence & Career 43:08 – Spike Protein Origins 57:10 – Nattokinase & Spike Clearance 58:50 – mRNA Persistence in Body 1:11:50 – Fixing the System 1:17:32 – Political Divisiveness 1:22:41 – Secrets to Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||
| This Ancient Hack Reverses Aging In 72 Hours : 1500 | 12 juil. 2026 | 00:14:13 | |
A Nobel Prize-winning discovery revealed that your body has a built-in repair system that can help clear out old cellular damage and support healthier aging from the inside out. In this video, Dave Asprey breaks down the strange Japanese breakfast ritual linked to some of the longest-living people on Earth, why modern life can shut down your body’s natural repair mode, and how one specific food may help wake it back up. You’ll learn how this process supports brain clarity, energy, inflammation, recovery, and biological age, plus how to use it through food, supplements, sleep, exercise, and testing so you can actually track whether your body is responding. Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors!
Timestamps: 0:00 – Japanese Breakfast Secret 1:02 – Damage vs. Repair 3:39 – What Is Autophagy? 6:03 – Natto & Longevity 7:34 – Using Spermidine Correctly 9:38 – The Under-Dosing Mistake 11:01 – Stacking Habits 12:21 – Measuring Biological Age 12:59 – Take Control of Your Biology Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info. | |||