In this episode, Dr. Grady and Dr. Garrett discuss stress, cortisol, and the potential nightmare of managing your blood sugar through it all. 

 

Topics Discussed:

- What is the Dawn Phenomenon?  - How does stress affect it? - What stressors affect cortisol and the Dawn phenomenon? - How does stress affect your blood sugar throughout the day? - The adrenals are not the problem! - How to reduce stress - The importance of having plenty of data to successfully manage blood sugar through stress - Steroid medicine and high blood sugar - How does stress and blood sugar affect the brain - How does stress and blood sugar affect your hormones - How to reduce stress - The importance of long-term stress management and good blood sugar control.

 

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In this episode, Dr. Grady and Dr. Garrett discuss the benefits and problems with intermittent fasting and how to do it as a T1D (type 1 diabetic).

 

Topics Discussed:

- Do we do Intermittent Fasting? - Importance of checking your blood sugar frequently while intermittent fasting - What diet makes it easier to fast? - What is intermittent fasting? - What can you consume during a fast without breaking it? - Should you ride out a low blood sugar or consume sugar during a fast - The importance of changing your basal rate and insulin dosage - Types of fasting - Importance of protein and blood sugar stability - Exercising in a fasted state and its effect on blood sugar and the rest of the body - Benefits of intermittent fasting  - Who should not do intermittent fasting? - How long or how frequent should you do intermittent fasting?

 

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In this episode, Dr. Grady and Dr. Garrett have the pleasure of interviewing Zach from Cedar Oak Kennels where he trains Diabetic Aert Dogs (DADs). He walks us through the training process, the breed that is best suited to be a DAD, and his why. All while sprinkling in some great success stories.

 

If you are interested in getting to know more about what Zach does and how to get ahold of him, you can visit his website, Instagram, or send an email.

 

Instagram: diabetic_alert_dog_training

Website: https://cedaroakkennels.com/

Email: cedaroakkennels@gmail.com

 

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 Time Stamps

0:25 - Introduction

1:10 - What Is a Diabetic Alert Dog? How Long Has Zach Been Doing This Work?

14:50 - What is the training process?

32:55 - Why British Labs are the best.

41:40 - Are there other breeds that Zach trains?

49:35 - How many people utilize DADs?

55:40 - How much does a DAD cost?

1:16:35 - Burst My Beta Cells

 

In this episode, Dr. Grady and Dr. Garrett interview Eric Zucaro who is a fitness fanatic. He has competed in a wide variety of events such as CrossFit, ultrarunning, obstacle racing, and Olympic lifting. We ask him about his training, diet, and how he was able to do all of this despite being T1D.

 

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In this episode, Dr. Grady and Dr. Garrett review a research article titled "Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives." We define what leaky gut is, how/why it develops, and how that relates to autoimmune and T1D. We discuss the importance of this information and the hope that it provides in the treatment of T1D. Research Article discussed: "Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives" https://diabetes.diabetesjournals.org/content/55/5/1443.long

 

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Time Stamps

0:25 - Introduction

2:10 - What is leaky gut

9:30 - Paper: Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives

21:50 - What causes increased zonulin and leaky gut?

25:00 - How does leaky gut lead to Autoimmune (T1D)?

32:20 - Does what you eat cause diabetes?

35:00 - Can you reverse T1D? Dr. Grady goes without insulin.

44:00 - What are other things that can affect your immune system and impact autoimmune besides diet?

47:00 - What is THE CURE of T1D?

49:50 - Stopping the development of a second autoimmune disease

54:00 - Burst My Beta Cells

In this episode, Dr. Grady and Dr. Garrett are "in studio" with each other after a few days of working out and hanging out. We talk what we ate, how we dosed insulin, and managed blood sugar while doing two very different workouts and eating out at a restaurant.

 

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 Time Stamps

0:25 - Introduction: Garrett Is In Town!!

2:20 - Yesterday’s HIIT Workout And How We Managed Our Blood Sugars Through It

9:03 - Managing BG after the workout and eating and while running out of insulin

15:50 - Today’s “bodybuilding” workout

18:50 - Dosing Our Insulin For Our HUGE Breakfast Before The Workout

27:40 - Not Being Afraid Changing Basal Rates And Dangers of Lows

33:40 - Our BG Post Workout

38:50 - Muggles Thinking That 160 BG Is Way High

40:30 - The Balance Of Enjoying Life And Monitoring Your Diabetes

44:49 - Burst My Beta Cells

 

In this episode, Dr. Grady and Dr. Garrett discuss all things sleep and blood sugar. We go over how what you do during the day (food, exercise, etc) affects your blood sugars through the night, the impact that your blood sugars have on your quality of sleep, the importance of sleep itself, and how that impacts your blood sugars the next day. 

 

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Time Stamps

1:02 - Introduction: Garrett’s Current Sleep Regime  2:12 - Why is sleep so important for Type 1 diabetics 7:24 - High Blood Sugar Leading to Increased Urination And Yo-Yoing  10:40 - Is Having High Blood Sugar At Night Better Than Being Low? 15:47 - Grady’s Near-Death Experience 26:00 - Having A System To Protect You From Dangerous Lows At Night When Living On Your Own  29:40 - What You Do During The Day Effects What Your Blood Sugar Is Like Through The Night 34:00 - Taking Control of Your Diabetes And Being Comfortable Changing Insulin Dosage 38:36 - How What You Eat And When You Eat Affects Your Blood Sugar Through The Night 44:50 - Exercise’s Effect On Blood Sugar Through The Night 53:35 - How Does Sleep Effect Blood Sugars The Next Day 2:08:55 - Grady And Garrett’s Daily Wins And Losses

In this episode, Dr. Grady and Dr. Garrett loosen up and shoot the breeze about their "wrastlin" days. We dive into the struggles we faced managing blood sugars throughout our wrestling careers, as well as blood sugar's effect on performance and what could have been. Then we share some "war stories". 

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Time Stamps

1:02 - Introduction: Boxes Up and Wrastlin’

2:55 - Garrett’s Terrible Weight Loss Strategies and The Effect on Performance

14:00 - Using Diabetes As An Excuse To Get Out Of Things

23:20 - If You Aren’t T1D Don’t Even Try Talking To Me About It

29:30 - Strategies For Managing BG Through Practices

46:00 - Diabetic Wrestling Stories

WE HAVE A NEW WEBSITE!!!!! CHECK IT OUT!!!!

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In this episode, Dr. Grady and Dr. Garrett discuss the controversy surrounding the Super Bowl ad that Dexcom made on Sunday. What was the goal/purpose of the ad? Was it to spread awareness of type 1 diabetes? Was it to spread awareness of the high prices of diabetes care? Or was it an advertisement for their product?

 

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In this episode, Dr. Donohoe and Dr. Panno discuss the frustrations of diabetes "tech" failing, such as the pump, glucometer, CGM, insulin, etc. We walk through our thought process when we see a high blood glucose reading. Is it due to food, our physiology, or our "tech?" We also talk about the mental/emotional tax that it has on you when you do everything right and yet you have poor blood sugar control due to something that is so unexpected and not necessarily your fault. 

 

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Time Stamps

1:39 - Start/Introduction

3:13 - You See A High BG Reading What Is Your Problem Solving Thought Process

27:05 - When Tech Fails: Pumps and MDIs

31:42 - Glucometer and CGM Failure

39:51 - What Do You Do When One Hand As A Different BG Reading Than The Other?

49:10 - Emotional Impact Of Tech Failing

 

In this episode, Dr. Donohoe and Dr. Panno discuss two of the most commonly used interventions, both in mainstream medical and functional medicine fields, Metformin and Berberine. Dr. Panno recently wrote a paper on this topic where he read through numerous research articles in order to gain more clarity and understanding of these two products (how they work and how effective they are). We get into the science behind them but also the clinical takeaways and what it all means. Below we reference all the articles used. 

 

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 Time Stamps

1:10 - Start/Introduction

6:25 - Berberine: What Does It Do And How Effective Is It?

16:30 - Where Does Berberine Come From?

22:45 - Where Does Metformin Come From?

31:30 - How Does Metformin Work? (MOA)

39:50 - How Does Berberine Work? (MOA)

44:10 - Can you take Metformin and Berberine Together?

57:30 - Burst My Beta Cells

 

Resources/Links Discussed in the episode:

References

1. Arayne, M., Sultana, N., & Bahadur, S., (2007). The berberis story: berberis vulgaris in therapeutics. Park J Pharm Sci; 20(1): 83-92. PMID: 17337435
2. Bailey, C., & Day, C., (2004). Metformin: its botanical background. Pract Diabetes Int; 21: 115-117. https://doi.org/10.1002/pdi.606
3. Bailey, C., & Day, C., (1989). Traditional plant medicines as treatments for diabetes. Diabetes Care; 12(8): 553-564. PMID: 2673695
4. Center of Disease Control (2020). National Diabetes Statistic Report 2020, Estimates of Diabetes and its burden in the united states. Retrieved at: https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf
5. Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., Chen, L., & Hatch, G., (2013). Berberine improves insulin resistance in cardiomyocytes via activation of 5’adenosine monophosphate-activated protein kinase. Metabolism; 62(8): 1159-1167. PMID: 23537779
6. Chang, W., Chen, L., & Hatch, G., (2015). Berberine as a therapy for type 2 diabetes and its complication: from mechanism of action to clinical studies. Biochem Cell Biol; 93(5): 479-486. PMID: 19800084
7. Cheuh, W., & Lin, J., (2012). Protective effect of berberine on serum glucose levels in non-obese diabetic mice. International Immunopharmacology; 12(3): 534-538. PMID: 22266065
8. Choi, YH., & Lee, MG., (2006). Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1, 3A1/2 for the metabolism of metformin. B J Pharmacol; 149(4): 424-30. PMID: 16940989
9. ClinCal (2020). The Top 200 Drugs of 2021. Medical Expenditure Panel Survey (MEPS). Retrieved at: https://clincalc.com/DrugStats/Top200Drugs.aspx
10. Dong, H., Wang, H., Zhao, L., & Lu, F., (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence Based complement alternative med; 2012: 591654. PMID: 23118793
11. Elbere, I., Kalnina, I., Silamikelis, I., Konrade, I., Zaharenko, L., Sekace, K., et al., Klovins, J., (2018). Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. PLoS One; 13(9): e0204317. PMID: 30261008
12. Foretz, M., Herbrad, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., et al., & Viollet, B., (2010). Metformin inhibits hepatic gluconeogenesis in mice independently of LKB1/AMPK pathway via a decrease in hepatic energy state. The Journal of Clinical investigation; 120(7): 2355-2369. PMID: 20577053
13. Fullerton, M., Galic, S., Marcinko, K., Sikkema, S., Pulinikunnil, T., Chen, Z., et al., & Steinberg, G., (2013). Single phosphorylation sites in ACC1 and ACC2 regulate lipid homeostasis in the insulin-sensitizing effects of metformin. Nat Med; 19(12): 1649-1654. PMID: 24185692
14. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G., (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia, and hypertension. Journal of Ethnopharmacology; 16H: 69-81. PMID: 25498346
15. Le Bastard, Q., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Montassier, E., Al, G. G. A., & Knights, D. (2018). Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications. Alimentary Pharmacology & Therapeutics, 47(3), 332. PMID: 29205415 
16. Li, Y., Wang, Y., Kong, W., Yang, P., Wang, Y., Li, Y., Yi, H., et al., & Jiang, J., (2011). Bioactivates of berberine metabolites after transformation throughout CYP450 isoenzymes. Journal of translational medicine; 9(62): 62. PMID: 21569619
17. Liang, Y., Xu, X., Yin, M., Zhang, Y., Haung, L., Chen, R., & Ni, J., (2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and meta-analysis. Endocrine Journal; 66(1): 51-63. PMID: 30393248
18. Lyu, Y., Zhang, Y., Yang, M., Lin, L., Yang, X., Cheung, S., et al., & Zuo, Z., (2019). Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sciences; 235: 116818. PMID: 31473193
19. Mao, L., Chen, Q., Gong, K., Xu, X., Xie, Y., Zhang W., et al., & Zhang, Y., (2018). Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells. Oncol Rep; 39(5). 2436-2442. PMID: 29565467
20. Miller, R., Chu, Q., Xie, J., Foretz, M., Viollet, B., & Birnbaum, M., (2013). Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP. Nature; 494(7436):256-260. PMID: 23292513
21. Neag, M., Mocan, A., Echeverria, J., Pop, R., Bocsan, C., Crisan, G., & Buzoianu, A., (2018). Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacology; 9: 557. PMID: 30186157
22. Owen, M., Doran, E., & Halestrap, A., (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondria respiratory chain. Biochem J; 348; 607-614. PMID: 10839993
23. Petersen, M., American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2017. Diabetes care; 41(5): 917-928. PMID: 29567642
24. Pryor R., & Cabreiro F., (2015). Repurposing metformin: an old drug with new tricks in its binding pockets. Biochemical Journal; 471(3): 307-322. PMID: 26475449
25. Ren, G., Guo, J., Quian, Y., Kong, W., & Jiang, J., (2020). Berberine improves glucose and lipid metabolism in HepG2 cells through AMPKα1 activation. Front Pharmacology; 11: 647. PMID: 32457629
26. Yin, J., Xing, H., & Ye, J., (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism; 57(5): 712-717. PMID: 18442638
27. Yue, S., Liu, J., Wang, W., Wang, A., Yang, X., Guan, H., Wang, C., & Yan, D., (2019). Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Biomed Pharmacother; 116: 109002. PMID: 31154270
28. Zhang, H., Wei, J., Xue, R., Wu, J., Zhao, W., Wang, Z., et al., & Jiang, J., (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism; 59(2): 285-292. PMID: 19800084
29. Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., et al., & Moller, D., (2001). Role of AMP-activated protein kinase in mechanisms of metformin action. The Journal of Clinical Investigation; 108(8): 1167-1174. PMID: 27654259

In this, episode Dr. Grady and Dr. Garrett have the pleasure of hearing Brandon Mouw's incredible journey from developing brittle diabetes to receiving a lifesaving pancreas-only transplant. His story is truly incredible. He has gone through so many struggles from trying to stay alive through years of battling constant lows to jumping through the hoops of trying to qualify and raise the money for a pancreas-only transplant. This is a great interview that you are guaranteed to enjoy.

If you would like to connect with Brandon follow him on Instagram (@brandonmouwofficial) or visit his website https://brandonmouw.com/ . And look for his new book coming in 2021!

 

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Time Stamps

1:10 - Start/Introduction

3:45 - Brandon’s Diabetes Management Early In Life

13:35 - The Kidney Stone From Hell That Sabotaged Brandon’s Health

16:35 - Life As a Brittle Diabetic Fighting Constant Lows

25:40 - Trying To Find Answers

31:40 - Starting The Journey Back To Life

36:20 - Brandon’s Motivation To Keep Moving Forward

42:40 - Raising Money To Get A New Pancreas 

55:40 - Waiting For THE CALL

1:01:50 - Getting THE CALL And Rushing Into Surgery

1:11:50 - The Uniqueness of A Pancreas-Only Transplant

1:19:10 - Recovering From Surgery And Preventing Rejection

1:36:00 - Coming Out The Other Side A Better Person And Trying To Stay Healthy

1:45:05 - How Does The New Pancreas Work? (I’m A Little Jealous)

1:50:50 - Burst My Beta Cells/ Diabetic Win 

1:58:35 - Brandon’s Book and Contact Info

 

In this episode, Dr. Grady and Dr. Garrett discuss functional medicine and holistic concepts about the thyroid, blood sugar regulation, and how diabetes can impact it. 

 

Topics Discussed:

- What does the thyroid do and why it is important? - How to assess thyroid function (What blood work to get) - What impacts your thyroid function? - Link between T1D and Autoimmune Thyroid disease  - How does blood sugar and stress affect thyroid function - Blood sugar, sex hormones, and thyroid hormone - How does thyroid function affect blood sugar - What are the things that cause or promote autoimmune diseases? - The importance of sleep

 

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In this Holiday Special, Dr. Grady and Dr. Garrett the chaos that the holidays bring into your health and how to combat it. We tell disastrous stories from past holiday celebrations and strategies that we use to avoid ending up in those situations again. We try to give you various tools that will hopefully allow you to successfully navigate the holiday season without derailing your health.

 

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 Time Stamps

1:10 - Start/Our Holiday Plans

4:55 - Chaotic Holiday Blood Sugar Stories

9:40 - Being Dialed In With Your Diabetes VS Being Dialed In With Your Health

18:35 - Mindset and Healthy Strategies Going Into The Holiday Season (Making Healthy Decisions)

28:20 - Grady’s Past Guilty Pleasures

32:25 - Grady’s Strategies To Avoid Those Guilty Pleasures

37:20 - Training Your Family To Allow You To Stay Healthy During Celebrations (Peer Pressure)

41:40 - Garrett’s Guilty Pleasure And Strategy/Mindset

45:05 - Strategies To Mitigate The Blood Sugar and Health Consequences If You ARE Going Off The Deep End With Your Diet

55:20 - Closing Tips To Get Through the Holidays As Healthy As Possible

59:15 - What We Are Looking Forward To For The Holidays And Next Year

In this episode, we have the pleasure of interviewing John Roth who was a commercial airline pilot for 20 years when his life was turned upside down by a diagnosis of type 1 diabetes. Since then he has been fighting for the ability of type 1 diabetics to earn a Class 1 and 2 medical certifications so that he and others can resume or pursue a career in aviation. We get into his struggles with the government, his diagnosis, and how he maintains such tight blood sugar control. 

If you would like to contact John to show support or get guidance, you can contact him via email or social media. 

Facebook (https://www.facebook.com/john.roth.1217) and instagram (@t1flyer)

flyroth16@yahoo.com

 

Resources/Links Discussed in the episode:

Suggested Facebook Groups:

• Pilots for the Advancement of Medical Standards https://www.facebook.com/PAMSApilots
• Flying with Diabetes https://www.facebook.com/groups/flyingwithdiabetes 

AOPA (Aircraft Owners and Pilots Association) https://www.aopa.org/ 

GetInsulin.org

 

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 Time Stamps

1:02 - Start

2:05 - John’s Diagnosis Story (Late in Life)

12:30 - Positive Mindsets Moving Forward

18:10 - Teaming Up With Other T1Ds  to Get Class 1 Medical Certification

29:15 - Proving T1Ds CAN Have Stable Blood Sugar and Setting “Tight” The Standards

36:15 - The Process of Figuring Out To Achieve “Tight” Control

45:15 - John’s Current Diet and Exercise Routine

56:35 - Carb Intake and Using Resistant Starches for Long Endurance Workouts

1:02:00 - Invest In Learning About Health (Most Of It Is Free)

1:04:05 - John’s Insulin Management (MDI)

1:08:00 - Coaching Other Diabetics (Type 1 and 2) To Achieve Better Blood Sugars

1:16:55 - Current Progress and Process To Get Class 1 Medical Certification Required To Fly Commercial Airplanes

1:28:40 - Current Process To Get Class 3 Medical Cert. (To Fly Private Planes)

1:31:25 - Future Goals for The T1D Airline Pilot Community

1:48:30 - Burst My Beta Cells

 1:54:45 - Diabetic Win

1:59:10 - John’s Closing Thoughts and Advice

In this episode, Dr. Donohoe and Dr. Panno talk about planning and executing a successful camping trip as a type 1 diabetic. We go into figuring out how much supplies to bring, packing and storing insulin, strategies to manage BG throughout the trip, and the various factors that impact BG. We then talk about Thanksgiving and how we approach the holiday so as to not wreck ourselves.

 

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 Time Stamps

1:02 - Start

4:35 - Preparing For A Camping Trip

17:55 - Food While Camping

29:30 - Dosing Basal and Long-acting Insulin According to Activity

36:25 - How to Pack and Store Insulin When Camping

47:05 - Managing Blood Sugar When Swimming

58:20 - The Sum of All the Positive and Negative Effects That Occur during Camping

1:00:15 - Alcohol Consumption When Camping

1:04:55 - Thanksgiving: Grady’s Thoughts 

In this episode, Dr. Donohoe and Dr. Panno walk through different scenarios in regards to blood sugar management before and during a leg day workout. We both utilize very different strategies. Garrrett likes to change pump settings whereas Grady uses more of an MDI approach by using bolus doses and juice to manage blood sugar.

 

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Time Stamps

1:02 - Start/Diabetes Awareness Month

5:55 - Types of Leg Day and Their Effect on Blood Sugar

21:15 - Leg Day Scenario 1 - Stable Blood Sugar at 120mg/dl for an Hour Before Workout

37:20 - Leg Day Scenario 2 - Stable Blood Sugar at 70-80mg/dl for an Hour Before Workout

45:55 - Leg Day Scenario 3 - Fasted Workout with a Stable Blood Sugar Going Into The Workout

56:40 - Leg Day Scenario 4 - Stable Blood Sugar at 60mg/dl or Below for an Hour Before Workout

1:08:25 - Leg Day Scenario 5 - Stable Blood Sugar at 200-220mg/dl for an Hour Before Workout

1:17:35 - Leg Day Scenario 6 - Yo-Yo Going High and Yo-Yo Going Low

1:28:30 - Wrap Up/Burst My Beta Cells 

In this episode, Dr. Donohoe and Dr. Panno discuss the obstacles of health. Primarily, we focus on the costs of mainstream healthcare, but also the expense of making healthier decisions like food, exercise, and individualized/preventative healthcare. And even though it's tough and it may not be our fault that we are in the condition of health that we are in, it is ultimately our responsibility to turn things around and strive for the best possible level of health.

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In this episode, Dr. Grady and Dr. Garrett talk with Jay Horley who was raised in the UK and now resides in Hong Kong, China and has been in the health and fitness industry for nearly a decade and a Type 1 diabetic since he was 14 years old. Jay shares his diabetic journey from struggles as a youth to digestive problems and nutrient deficiencies to where he is now which is successfully pursuing optimal health using a carnivore diet.  We dive deep into the carnivore diet, how it has changed his health, and how he manages his diabetes. This conversation was very interesting and eye-opening, to say the least.

 

You can follow Jay on Instagram @diabetic.carnivore

 

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Time Stamps

2:08 - Early Diabetic Years

9:01 - Some Differences In Diabetes Supplies In The United Kingdom and Asia

14:02 - HRV (Heart Rate Variability) & Gut Dysfunction Led Jay On His Quest For Optimal Health

20:39 - Taking The First Bite: Starting Carnivore

30:00 - Protein Volume and Calorie Volume

31:16 - Matching Different Insulin Types To Different Diets

44:40 - Meat:Organ Ratios

53:10 - Hypoglycemia On A Carnivore Diet

58:55 - HRV, Recovery, Overtraining

1:06:20 - Longevity And Sustainability Of Carnivore

1:11:45 - Intermittent Fasting With T1D

1:16:55 - Many Forms of Training And Diabetes Balance

1:30:50 - Burst My Beta Cells

Dr. Stephen Hussey is a Chiropractor, has a Masters in Human Nutrition and Functional Medicine, a very strong advocate of a low carb/animal based diet, has two books, 

- The Health Evolution: Why Understanding Evolution is the Key to Vibrant Health and 

- The Heart: Our Most Medically Misunderstood Organ

Dr. Hussey has been on a number of podcasts and sees patients ranging from a variety of chronic different disorders such as heart disease, autonomic imbalances, diabetes and more. 

And the coolest thing about Dr. Hussey, is he too is a type one diabetic!

In this episode, we discuss many health topics ranging from diets, diabetes, insulin resistance/sensitivity, heart disease, immune function, allergies, among other things. It was a pleasure picking Dr. Hussey's brilliant mind.

You can find Dr. Hussey on instagram @DrStephenHussey and on his website https://www.resourceyourhealth.com/

 

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Time Stamps

0:00 - Intro

1:56 - Dr. Hussey's T1D Story

6:33 - Good Pediatric Endocrinologist and Teenage Years

11:51 - 20+ Years of using an insulin pump and switching to MDI

13:20 - Animal/Carnivore based diet with Type 1 Diabetes Management

15:10 - How to "Lick a Cat" using diet to manage inflammatory conditions and pathways

21:29 - Constant Insulin Monitor? Insulin utilization in T1D vs non-Diabetic

29:13 - One Day or Day One - Dr. Hussey's passion for health

35:00 - The Greater impact of diet and health on the world around us

40:45 - Causes of Chronic Disease: More then just poor diet and exercise

42:00 - Toxins, Autonomic Nervous System (ANS) Imbalances, EMFs

45:40 - How lifestyle impacts our autonomic balance

53:30 Creating balance in the ANS

1:01:16 - Diabetes and ANS imbalances

1:03:30 - Heart Disease as a Chronic Disease

1:06:41 - What is metabolic flexibility

1:13:20 - Insulin Metabolism and Misconceptions

1:20:29 - Vegetable oils - Insulin Sensitivity in Adipose isn't all its cracked up to be

1:29:47 - The understandable but unnecessary fear of "injecting too much insulin" as a T1D

1:32:40 - Why diabetics should focus more on inflammation

1:38:00 - Burst My Beta Cells

1:48:09 - More info on Dr. Hussey

In this episode, Dr. Grady and Dr. Garrett continue their conversation from last episode on the article "Modeling insulin resistance in rodents by alterations in diet: what have high-fat and high-calorie diets revealed?" This time we dive into how diets effect glucose metabolism, but how to also keep in mind your health goals when implementing a dietary lifestyle.

 

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Time Stamps:

0:00 - Appreciating Nutritional Research Critically

4:40 - Range of Fat % in High Fat Diets (HFD) and Keto

11:30 - How Different Fatty Acids Create Different Metabolic Changes

14:50 - HFD + Omega 3 Supps Improve Insulin Sensitivity

19:30 - Saturated Fat Lengths and Fatty Sources

22:35 - Dr. Donohoe's MANY uses for coconut oil

27:35 - High Fat/High Sucrose (HSHS) diets AKA Standard American Diet (SAD)

29:55 - Epigenetics and HFHS

34:33 - Epigenetics and T1D Patterns

37:43 - Expansion on the SAD

43:00 - "Cafeteria" and "Choice" diets

46:48 - High Carb Diets (HCD): Picking a side is better then the combo

55:10 - HCD effect on Insulin Resistance (IR)

56:10 - Fructose's role on Hepatic IR

1:06:49 - Controls in HCD vs HFD

1:10:25 - Playing Devils Advocate Against One's Own Bias

1:14:10 - Altering Protein Content in Diets

1:18:23 - Dr. Panno's attempt at Amino Acid case study

1:20:50 - Protein Powder vs Food Sources

1:23:52 - Diabetic Win: Bone Broth Protein and night time blood sugars

1:27:00 - Diabetic Win: Mr. Incredible at Medtronic

 

Resources/Links Discussed in the episode:

Small, Lewin, et al. “Modeling Insulin Resistance in Rodents by Alterations in Diet: What Have High-Fat and High-Calorie Diets Revealed?” American Journal of Physiology-Endocrinology and Metabolism, vol. 314, no. 3, 2018, doi:10.1152/ajpendo.00337.2017.

In this episode, Dr. Grady and Dr. Garrett discuss the mechanisms of insulin resistance in various tissues in the body (muscle, liver, fat). This leads to several digressions about lifestyle habits that will that will affect these tissues directly to improve insulin resistance, such as exercise and muscle glucose metabolism. We also talk about what "Bursts Our Beta Cells" and a diabetic win that we recently had.

 

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Time Stamps:

0:36 - Grady's "Burst My Beta Cells": Insurance and Pharmacies

9:53 - Garrett's "Bursts My Beta Cells": Margaritas, Celebration and T1D

15:03 - Diet Induced Obesity for Insulin Resistance (IR) Models and Studies

22:04 - Importance of Muscle Physiology

25:50 - Moving Your Body for Metabolism and Insulin Sensitivity

35:10 - 4 Major IR Models within Myocytes (Muscle Cells)

37:19 - Intracellular Lipids within Myocytes (Muscle Cells)

41:53 - Explanation on Glucose Sparing

45:07 - Athlete Paradox with Intracellular Lipids

50:06 - TAGs and Lipid Panels in Context of Muscle Physiology

55:10 - Mitochondria Dysfunction within Myocytes

1:02:38 - IR within Hepatocytes (Liver Cells) Definition

1:12:58 - IR in the Liver and NAFLD

1:15:43 - IR Liver Leads to Increased Lipogenesis and Transportation

1:19:33 - Brief Discussion on IR and Adipose Tissue

1:23:58 - Personal Diabetes Win

 

Resources/Links Discussed in the episode:

Small, Lewin, et al. “Modeling Insulin Resistance in Rodents by Alterations in Diet: What Have High-Fat and High-Calorie Diets Revealed?” American Journal of Physiology-Endocrinology and Metabolism, vol. 314, no. 3, 2018, doi:10.1152/ajpendo.00337.2017.

In this episode, Dr. Grady and Dr. Garrett discuss all things fat. We get into the differences in dietary fat, body fat, and visceral fat. We also go over saturated fatty acids, mono- and polyunsaturated fatty acids, omega fatty acids, what they all are and what they do for/to the human body. We then touch on the ketogenic diet and how all of this affects insulin sensitivity.

 

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Time Stamps:

2:33 - What is basic insulin resistance?

6:00 - How T1D and T2D use insulin differently

9:00 - Efficiency of insulin sensitivity (IS)

12:05 - Markers of IS

13:05 - Lipid Panel and it's relationship to IS

21:15 - C-peptide and other biomarkers of IS

24:07 - Adipose Tissue Threshold Theory

31:12 - Dietary Carbs and Fats

36:30 - Different types of Fats

39:05 - Saturated fats in food vs Saturated fats in the blood

44:47 - Omega 3's and Omega 6's

56:00 - Is ketosis magical?

1:01:50 - Timing of Carbs

1:03:15 - Epilepsy and the brain with keto

1:10:35 - Individualized Nutrition and Medicine

1:17:13 - What really bursts your beta cells?

 

Resources/Links Discussed in the episode:

• Adeva-Adany, M., Martinez-Rodriguez, J., Gonzalez-Lucan, M., Fernadez-Fernadez, C., Castro-Quintela, E., (2019). Insulin Resistance is a cardiovascular risk factor in humans.  Diabetes and Metabolic Syndrome: Clinical Research & Reviews; 13(2): 1449-1455. Retrieved at: https://www.sciencedirect.com/science/article/abs/pii/S1871402119300785
• Cox, N., Gibas, S., Salisbury, M., Gomer, J., & Gibas, K., (2019). Ketogenic diets potentially reverse Type II diabetes and ameliorate clinical depression: a case study. Diabetes and Metabolic Syndrome: Clinical Research & Reviews; 13(2): 1475-1479. Retrieved at: https://www.sciencedirect.com/science/article/abs/pii/S1871402119300189
• Nunes, E., & Rafacho, A., (2017). Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes. Current Drug Targets; 18(6): 619-628. Retrieved at: https://pubmed.ncbi.nlm.nih.gov/26648072/
• Ricci, A., Idzikowski, M., Soares, C., & Brietzke, E., (2020). Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet. Reviews in Neuroscience; ahead of print, https://doi.org/10.1515/revneuro-2019-0073, retrieved at:  https://pubmed.ncbi.nlm.nih.gov/32406387/

• Strandberg, Timo E., et al. “Increased Mortality Despite Successful Multifactorial Cardiovascular Risk Reduction in Healthy Men: 40-Year Follow-Up of the Helsinki Businessmen Study Intervention Trial.” The Journal of Nutrition, Health & Aging, vol. 22, no. 8, 2018, pp. 885–891., doi:10.1007/s12603-018-1099-0 https://pubmed.ncbi.nlm.nih.gov/30272088/ 

   

• Vazquez-Jimenez, J., Chavez-Reyes, J., Romero-Garcia, T., … & Olivares-Reyes J., (2016). Cell Signal; 28(1): 59-59. Retrieved at: https://pubmed.ncbi.nlm.nih.gov/26475209/
• Xiong, SW., Cao, J., Liu, XM., Deng, XM., Liu, Z., & Zhang, FT., (2015). Effect of modification ROux-enY Gastric Bypass Surgery on GLP-1, GIP, in patients with Type 2 Diabetes Mellitus. Gastroenterology Research and Practice; 625196. Retrieved at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488585/#:~:text=The%20results%20suggested%20that%20modified,glucose%20of%20patients%20with%20T2DM.
• Volk, B., Kunces, L., Freidenreich, D., … & Volek, J., (2019). Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome. PLOS ONE; 9(11): retrieved at: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113605

 

In this episode, Dr. Grady and Dr. Garrett go through everything you should know, think about, and do to successfully be a runner as a T1D (type 1 diabetic).

 

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Topics Discussed:

- Fear of Running as a Type 1 Diabetic - Preparation: Carrying sugar, tester, phone, etc - Start Slow and check your blood sugar often (Get Data!) - Don't be afraid to stop - False High Blood Sugars (sugar on the finger) - Signs of low blood sugar while running - Checking Blood Sugar while running or CGM - Rewards/Benefits of running - What happens to your blood sugar during the running - Strategies for managing your blood sugar before, during, and after the run (short, mid, and long-distance runs) - Running with severe high blood sugar - Different correction factors for severe highs vs moderately high blood sugar - How to track and utilize data to better manage your blood sugar, especially for longer runs (Dr. Garrett gives a real-life example) - How stress and sleep affects your blood sugar differently during a run - How the time of day affects your blood sugar during a run

In this episode Dr. Donohoe and Dr. Panno discuss digestion, post-prandial (post-meal) glucose, and how they each affect one another.  We go over several studies that assess gastric emptying time (rate of digestion) and its impact on post-prandial glucose spikes and stability. We cover the various things that can change gastric emptying time and how you can use this information to better control your blood sugar.

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Time Stamps

• 2:11 - Why Carbs are not the only factor for dosing a meal?
• 4:20 - Defining Post-Prandial Glucose and Gastric Emptying (GE)
• 6:05 - Common Symptoms for Digestive Issues for Non-Diabetics, Type 1’s and Type 2’s
• 9:52 - The 3 Main Factors that affect the Postprandial response
• 14:40 - You can get Neuropathy on your stomach? Autonomic Neuropathy and Digestion
• 22:25 - More Accurate (Nerdy) Definition of Gastric Emptying 
• 23:45 - The 3 Main Factors of Macronutrients and their Impact on Gastric Emptying
• 27:00 - Blood Sugar’s Impact on the Motility of Food in Non Diabetics and Diabetics 
• 34:51 - Meal Characteristics with the macronutrients (Carb/Protein/Fat)
• 43:16 - Cholecystectomy (Removal of Gallbladder), and its impact on Digestion and therefore Blood Sugar
• 50:03 - Different Insulin Dosage Strategies for different macronutrients 
• 57:56 - SO WHAT? How can we use GE in the future to manage blood sugar?
• 1:10:41 - Applying GE to specific diets (Keto/Vegan/Low Carb, etc) and other health conditions 
• 1:14:39 - Bursts My Beta cells

 

Resources/Links Discussed in the episode:

Lupoli, Roberta, et al. “Gastric Emptying Impacts the Timing of Meal Glucose Peak in Subjects With Uncomplicated Type 1 Diabetes.” The Journal of Clinical Endocrinology & Metabolism, vol. 103, no. 6, 2018, pp. 2269–2276., doi:10.1210/jc.2017-02811.

Lupoli, Roberta, et al. “Postprandial Glucose Control in Type 1 Diabetes: Importance of the Gastric Emptying Rate.” Nutrients, vol. 11, no. 7, 2019, p. 1559., doi:10.3390/nu11071559.

Marathe, Chinmay S., et al. “Hypoglycaemia and Gastric Emptying.” Diabetes, Obesity and Metabolism, vol. 21, no. 3, 2018, pp. 491–498., doi:10.1111/dom.13570.

Smart, C. E. M., et al. “Both Dietary Protein and Fat Increase Postprandial Glucose Excursions in Children With Type 1 Diabetes, and the Effect Is Additive.” Diabetes Care, vol. 36, no. 12, 2013, pp. 3897–3902., doi:10.2337/dc13-1195.

In this episode Dr. Grady Donohoe outlines one of the greatest advancements in blood sugar management. With CGMs, both diabetics (type 1 and 2) and non-diabetics can so much data from these little devices that they can use to master the balancing act of staying "in range" and lowering HbA1c. He talks about the difference of CGMs and finger stick glucometers, the 3 available CGM systems, and how to use them to make less guesses and more educated decisions when it comes to managing your blood sugar (whether you are diabetic or not).

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Resources/Links Discussed in the episode:

Beck, Roy W., et al. “Effect of Continuous Glucose Monitoring on Glycemic Control in Adults With Type 1 Diabetes Using Insulin Injections.” Jama, vol. 317, no. 4, 2017, p. 371., doi:10.1001/jama.2016.19975.

Lind, Marcus, et al. “Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections.” Jama, vol. 317, no. 4, 2017, p. 379., doi:10.1001/jama.2016.19976.

Shah, Viral N, et al. “Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study.” The Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 10, 2019, pp. 4356–4364., doi:10.1210/jc.2018-02763.

In this episode we interview the Kash Family (Connor, Elizabeth, and Bryan). Their whole world changed when Connor was diagnosed at the age of 4. There are a lot of challenges that come with having a young one with T1D. We had a great time talking with Connor, who is now 12, and his parents and hearing how they have overcome those challenges. It was also inspiring to hear their attitude and mindset in regards to owning diabetes and not letting it stop Connor from living his life.

This is a great podcast for families going through a similar situation or anyone looking for a positive uplifting conversation that will make their day brighter.

 

Episode Contents:

1:55 - Connor's Diagnosis from his parent's point of view

10:45 - Adaptations and Carb Counting as a Family

19:05 - T1D and Starting School

22:45 - First Experiences with CGMs

29:00 - Using CGMs as a kid in school

33:44 - Involvement in the Diabetic Community

43:35 - Experiences with injecting insulin as a family

46:00 - Empowering Connor to take control of his diabetes

51:14 - Placement of diabetes Tech for an active kid

54:25 - Connor's challenges of self management

1:03:10 - Parenting Experiences

108:58 - Not allowing diabetes to stop you

1:14:03 - If others could only know...

1:29:14 - "Burst My Beta Cells" and wrap up

 

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     In this episode we have the pleasure of interviewing Rodney Miller who is a Type 1 diabetic with a passion for strength training. Rodney is the founder of Bolus and Barbells, a non-profit organization that hosts events that provides lectures and hands-on education about resistance training as a type 1 diabetic. He also does one-on-one coaching for diabetics that are looking to maximize their performance while controlling their blood sugar. Rodney takes us through the challenges that many diabetics face when strength training and strategies to successfully navigate them.

To find out more about Rodney and his organization:

- bolusandbarbells.org

- Follow Bolus and Barbells on Facebook and Instagram

- You can also follow him on Instagram at @StrongLikeTroll

 

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In this episode Dr. Grady Donohoe and Dr. Garrett Panno discuss several strategies to support the various systems in your body that play a role in how your body fights off disease. Also, Garrett has some big news to share with us!!

Episode Contents:

2:05 - Wholistic Mindset To Fighting Off Disease

3:45 - Barrier Systems (Skin, GI Tract, Lungs)

7:50 - The Gut and Probiotics

17:00 - High Carbs, Insulin Resistance and Immune System

20:45 - Stress Responses and the HPA Axis

24:05 - Sleep Strategies

27:30 - Posture and the Lymphatic System

30:03 - Circulation, Detoxification, and Elimination Considerations

39:04 - Vitamin D - Immune Modulator

42:23 - Vitamin A and C

47:50 - Garrett's Big Announcement!

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Resources/Links Discussed in the episode:

  Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review (2019): https://www.ncbi.nlm.nih.gov/pubmed/31752913

•         Influence of Resveratrol on the Immune Response (2019): https://www.ncbi.nlm.nih.gov/pubmed/31035454
•         Modulation of immunity and inflammatory gene expression in the gut in Inflammatory diseases of the gut and in the liver by probiotics. https://www.ncbi.nlm.nih.gov/pubmed/25400447
•         Resveratrol therapeutic combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae (2017): https://www.ncbi.nlm.nih.gov/pubmed/29038519
•         Resveratrol reduces liver endoplasmic stress and improves insulin sensitivity in vivo and in vitro (2019): https://www-ncbi-nlm-nih-gov.uws.idm.oclc.org/pmc/articles/PMC6505469/
•         Role of immune cells in obesity induced low grade inflammation and insulin resistance (2017): https://www.ncbi.nlm.nih.gov/pubmed/28285710
•         Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation (2015): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939543/
•         Vitamin D Nutrient, Hormone and Immunomodulator (2018): https://www.ncbi.nlm.nih.gov/pubmed/30400332

In this episode, Dr. Grady and Garrett attempt to clear up the question, "what does it mean to be "immune compromised"? As diabetics we are often told that we are immune compromised or immune deficient, but is it that simple? Simply diabetic, does automatically mean we are immune compromised? We address these questions and attempt to provide a more complete picture of the immune system in relation to fighting off disease, and the many body systems that work with your immune system to get the job done. They also talk about various factors that can suppress the immune system and its ability to fight infections.

Table of Contents:

3:07 - What is immunocompromised/immune deficient?

6:35 - CBC w/ diff break down

12:40 - Lymphatic system and the immune system

22:25 - What does immune compromised mean for diabetics?

26:35 - Diabetics' general infection and complication risk

30:00 - How the immune system of a diabetic is different

35:00 - The type of infection that diabetics are at greater risk for

36:20 - High blood sugar while you are sick

39:00 - Lymphocytopenia with COVID-19 and diabetes

41:44 - Do you need to have additional fear as a diabetic specifically?

45:10 - Co-morbidities and considerations for overall health

57:03 - Cardiovascular system, hypertension and Sars-CoV-2

 

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Resources/Links Discussed in the episode:

Holt, R.I.G., Cockram, C.S., Flyvbjerg, A., Goldstein, B.J., (2017). Chapter 55, p799, Diabetes and Infections. Textbook of Diabetes, Fifth Edition. Wiley Blackwell publishing.

Knipe, H., & Bell, DJ., (April 2020). COVID-19. Radiopedia. https://radiopaedia.org/articles/covid-19-3?lang=us

Hawryluk, M., (April 6 2020). Mysterious Heart Damage, Not Lung Troubles, Befalling COVID-19 Patients. Kaiser Health News. https://khn.org/news/mysterious-heart-damage-not-just-lung-troubles-befalling-covid-19-patients/

(March 2020). Here’s the Damage Coronavirus (COVID-19) Can do to Your Lungs. Cleveland Clinic, Health Essentials. https://health.clevelandclinic.org/heres-the-damage-coronavirus-covid-19-can-do-to-your-lungs/

Life with T1D, (March 24, 2020). Your Coronavirus Questions Answered. JDRF. https://www.jdrf.org/blog/2020/03/24/answering-your-questions-coronavirus/

Wang, D., Hu, B., Hu, C., et al., (2020). Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus Infected Pneumonia in Wuhan, Chian. JAMA; 323(11): 1061-1069. https://jamanetwork.com/journals/jama/fullarticle/2761044

Patel, PS., Buras, ED., & Balasubramanyam, A., (2013). The Role of the Immune System in Obesity and Insulin Resistance. Journal of Obesity; 616193:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618935/

In this episode we invite a good "Diabuddy" of ours to come on and share his diabetic story and how he has navigated the many obstacles and obligations in his life. Chuck takes us through his childhood growing up loving to play hockey, a passion which then lead into coaching, and how he was able to continue to do what he loves despite being a diabetic. He then talks about being hit with another autoimmune diagnosis of psoriatic arthritis and how that opened his eyes to the importance of developing healthier habits. He also talks about being a husband and becoming a father as a type one diabetic. We appreciate Chuck coming on and sharing with us.

 

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In this episode, Dr. Grady and Garrett discuss a research article “Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial.” We go over what we like and don’t like about the study as well as what the results mean for people trying to manage their type 2 diabetes.

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Resources/Links Discussed in the episode:

Tay, Jeannie, et al. “Comparison of Low- and High-Carbohydrate Diets for Type 2 Diabetes Management: a Randomized Trial.” The American Journal of Clinical Nutrition, vol. 102, no. 4, 2015, pp. 780–790., doi:10.3945/ajcn.115.112581.

In this episode, Dr. Grady and Garrett discuss running with type 1 diabetes. We talk about some of our experiences with running and strategies that we use to manage our blood sugar levels before, during, and after the run.

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In this episode, Dr. Grady and Garrett discuss something that is not talked about a lot in diabetes education, PROTEIN!! That’s right, carbs are not the only thing you need to think about when managing blood sugar levels.  We talk about how it can affect blood sugar in both type 1 and type 2 diabetes. We also go over various sources of protein and the advantages and disadvantages of each.

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Resources/Links Discussed in the episode:

• Evans, M., et al. “Dietary Protein Affects Both the Dose and Pattern of Insulin Delivery Required to Achieve Postprandial Euglycaemia in Type 1 Diabetes: a Randomized Trial.” Diabetic Medicine, 2018, doi:10.1111/dme.13875.
• Editor, (2019, January). Type 1 Diabetes study shows dietary protein is linked with additional insulin needs. Retrieved at: https://www.diabetes.co.uk/news/2019/jan/type-1-diabetes-study-shows-dietary-protein-is-linked-with-additional-insulin-need-94221545.html
• Huang, Z., Wang, Y., Shafer, R., Winn, NC., Kanaley, JA., Vardhanabhuti, B., (2019). Glycemic effects following the consumption of mixed soy protein isolate and alginate beverages in healthy adults. Food and Function; 10(3): 1718-1725. doi: 10.1039/c8fo01627e.
• Natarajan Sulochana, K., Lakshmi, S., Punitham, R., Arokiasamy, T., Sukumar, B., & Ramakrishnan, S., (2002). Effects of oral supplementation of free amino acids in type 2 diabetic patients – a pilot clinical trail. Med Sci Monit; 8(3): CR131-7. Pubmed ID: 11887024.
• Srinivasan, V., Radhakrishnan, S., Angayarkanni, N, & Sulochana, KN., (2019). Antidiabetic effect of free amino acids supplementation in human visceral adipocytes through adiponecting dependent mechanism. Indian J Med Res; 149(1): 41-46. doi: 10.4103/ijmr.IJMR_1782_16.

The Diabuddies are back for a limited season. In this episode, Dr. Grady and Dr. Garrett talk about what they have been up to since last year and the new diabetic struggles that they have been dealing with. 

 

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Topics Discussed:

1:53 - Podcast start 4:45 - Catching up with the Diabuddies -Dario Blood Sugar Monitoring System - Slacking on blood sugar monitoring - Weather Effecting Blood sugar management  - Tinkering with basal rates - Managing Blood sugar without a CGM (continuous glucose monitor) - Freestyle Libre CGM - Good Rx for more affordable prescriptions - Workouts, running marathons

 

Join Dr. Grady and Garrett on this episode of The Diabuddies Podcast as they discuss their diagnosis stories, as well as conversations on Diabetic Ketoacidosis (DKA), fasting, and deeper conversations on identity, self-worth, and how one defines themself.

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Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

In this episode, we discuss all things carbohydrates including glycemic index, glycemic load, simple vs complex carbs, fiber, fructose, and sugar alcohols. Most importantly, we talk about how to take this information into account when dosing insulin. We top it off with a segment on what #BurstMyBetaCells.

 

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Resources/Links Discussed in the episode:

Glycemicindex.com 

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

In this episode, we discuss why it is important for us to maintain good blood sugar control. We talk about the immediate benefits of good blood sugar levels such as sleep, mental and physical performance, and brainpower. We also get into the long-term considerations of maintaining tight blood sugar control like circulation, eyes, and kidney health. 

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Resources/Links Discussed in the episode:

“The Diabetes Control and Complications Trial (DCCT): Design and Methodologic Considerations for the Feasibility Phase.” Diabetes, vol. 35, no. 5, 1986, pp. 530–545., doi:10.2337/diab.35.5.530.

Gaete, Ximena, et al. “Menstrual Cycle Irregularities and Their Relationship with HbA1c and Insulin Dose in Adolescents with Type 1 Diabetes Mellitus.” Fertility and Sterility, vol. 94, no. 5, 2010, pp. 1822–1826., doi:10.1016/j.fertnstert.2009.08.039.

Huang, Chun-Jen, et al. “Prevalence and Incidence of Diagnosed Depression Disorders in Patients with Diabetes: a National Population-Based Cohort Study.” General Hospital Psychiatry, vol. 34, no. 3, 2012, pp. 242–248., doi:10.1016/j.genhosppsych.2011.12.011.

King, Paromita, et al. “The UK Prospective Diabetes Study (UKPDS): Clinical and Therapeutic Implications for Type 2 Diabetes.” British Journal of Clinical Pharmacology, vol. 48, no. 5, 2001, pp. 643–648., doi:10.1046/j.1365-2125.1999.00092.x.

#6 Dysglycemia and Brain Health

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

In this episode, Dr. Donohoe and Garrett discuss poor blood sugar control in the non-diabetic person and the importance of recognizing blood sugar instability. Along those lines, we talk about the role that dysglycemia has in the development of issues with brain function, from brain fog to Alzheimer’s.

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Resources/Links Discussed in the episode:

• Barbagallo, M., & Dominguez, L., (2014). Type 2 diabetes mellitus and Alzheimer’s disease. World Journal of Diabetes; 5(6): 889-893. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265876/
• Janson J., Laedtke, T., Parisi, J.E., O’Brien, P., Petersen, R.C., & Butler, P.C., (2004). Increased risk of type 2 Diabetes in Alzheimer disease. Diabetes; 53(2): 474-481. https://www.ncbi.nlm.nih.gov/pubmed/14747300
• Arvanitakis, Z., Wilson, RS., Brienias, J.L., Evans, D.A., & Bennett, D.A., (2004). Diabetes mellitus and risk of ALzheimer disease and decline in cognitive function. Arch Neurol; 61(5): 661-666. https://www.ncbi.nlm.nih.gov/pubmed/15148141
• Wu, William, et al. “The Brain in the Age of Old: The Hippocampal Formation Is Targeted Differentially by Diseases of Late Life.” Annals of Neurology, vol. 64, no. 6, 2008, pp. 698–706., doi:10.1002/ana.21557.
• Peixoto, Christina Alves, et al. “AMPK Activation: Role in the Signaling Pathways of Neuroinflammation and Neurodegeneration.” Experimental Neurology, vol. 298, 2017, pp. 31–41., doi:10.1016/j.expneurol.2017.08.013.

Episode #5 Management of Type 2 Diabetes

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

In this episode, Dr. Donohoe and Garrett discuss the management of Type 2 Diabetes and the mechanisms of how diet and exercise are such powerful tools when trying to achieve optimal blood glucose levels. We also get into sleep and stress management in regards to blood sugar.

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Resources/Links Discussed in the episode:

• Richter, E.A., & Hargreaves, M., (2013). Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews; 93(3):993-1017. https://www.physiology.org/doi/full/10.1152/physrev.00038.2012?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
• Niu, Y., et al., (2017). Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. BBA Molecular Basis of Disease; 1863(9):2372-2381 https://www.sciencedirect.com/science/article/pii/S092544391730220X?via%3Dihub
• Yin, J., Xing, H., & Ye, J., (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism; 57(5): 712-717. https://www.ncbi.nlm.nih.gov/pubmed/18442638

• Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z., (2018). Metformin and berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget; 9(11): 10135-10146. https://www.ncbi.nlm.nih.gov/pubmed/29515798
• De Souza, JFT., Dattilo, M., de Mello, MT., Tuflk, S.,&  Antunes, HKM (2017). High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males. Front Physiol; 8: 992. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725446/
• Ahmed, A. Bakrudeen Ali, et al. “In Vitro Callus and in Vivo Leaf Extract of Gymnema Sylvestre Stimulate β-Cells Regeneration and Anti-Diabetic Activity in Wistar Rats.” Phytomedicine, vol. 17, no. 13, 2010, pp. 1033–1039., doi:10.1016/j.phymed.2010.03.019.
• Al‐Romaiyan, Altaf, et al. “A Novel            Gymnema Sylvestre Extract Protects Pancreatic Beta‐Cells from Cytokine‐Induced Apoptosis.” Phytotherapy Research, 2019, doi:10.1002/ptr.6512.
• Kuo, Daih-Huang, et al. “Body Weight Management Effect of Burdock (Arctium Lappa L.) Root Is Associated with the Activation of AMP-Activated Protein Kinase in Human HepG2 Cells.” Food Chemistry, vol. 134, no. 3, 2012, pp. 1320–1326., doi:10.1016/j.foodchem.2012.03.023.
• Lan, Jiarong, et al. “Meta-Analysis of the Effect and Safety of Berberine in the Treatment of Type 2 Diabetes Mellitus, Hyperlipemia and Hypertension.” Journal of Ethnopharmacology, vol. 161, 2015, pp. 69–81., doi:10.1016/j.jep.2014.09.049.
• Lee, Woo Je. “α-Lipoic Acid Increases Insulin Sensitivity by Activating AMPK in Skeletal Muscle.” Biochemical and Biophysical Research Communications, vol. 332, no. 3, 2005, pp. 885–891., doi:10.1016/j.bbrc.2005.05.035.
• Magistrelli, Ashley, and Jo Carol Chezem. “Effect of Ground Cinnamon on Postprandial Blood Glucose Concentration in Normal-Weight and Obese Adults.” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 11, 2012, pp. 1806–1809., doi:10.1016/j.jand.2012.07.037.
• Viollet, Benoit. “Targeting the AMPK Pathway for the Treatment of Type 2 Diabetes.” Frontiers in Bioscience, Volume, no. 14, 2009, p. 3380., doi:10.2741/3460.
• Wei, Wei, et al. “A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.” European Journal of Endocrinology, vol. 166, no. 1, 2012, pp. 99–105., doi:10.1530/eje-11-0616.

Episode 4: What is Type 2 Diabetes?

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

• In this episode, we discuss what Type 2 Diabetes is and how it develops. We then get into various factors that contribute to the high blood sugar and insulin resistance involved in Type 2 Diabetes. We also go over the many organ systems that are affected by Type 2 Diabetes. We conclude by sharing a "Freedom Moment" that we recently had with our diabetes.

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Resources/Links Discussed in the episode:

• Shi, X., et al., (2016). Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutrition Journal; 15: 103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192567/
• Petersen, M.C., & Shulman, G.I., (2018). Mechanisms of Insulin Action and Insulin Resistance. Physiology Reviews; 98(4): 2133–2223. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/
• Burhans, M.C., et al., (2018). Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr Physiol; 9(1): 1–58.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557583/

Episode 3: Management of Type 1 Diabetes

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

• In this episode, we discuss the management of Type 1 Diabetes which includes: shots vs pumps, the different types of insulin, CGMs and the importance of checking blood glucose frequently. We also get into the importance of sleep, diet, and exercise. To conclude, Garrett and Dr. Grady each share a challenge that they recently faced with their diabetes and how they were able to overcome it and what they learned from it. 

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Episode 2: What is Type 1 Diabetes?

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

• In this episode, we discuss what Type 1 Diabetes is and how it develops. We also talk about insulin and how it works. To conclude, we go over the challenges that Type 1 Diabetics face and what really "Burst My Beta Cells".

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Resources/Links Discussed in the episode:

• Mincu, I., Ionescu-Tigoviste, C., (1980). Half-life and hypoglycemic effect of intravenous insulin in patients with diabetic ketoacidosis. Med Interne; 18(3): 287-292. https://www.ncbi.nlm.nih.gov/pubmed/6774410

Episode 1: Introduction

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

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Resources/Links Discussed in the episode:

• Gavrilova, O., et al., (2000). Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. The journal of clinical investigation; 105(3): 271–278. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC377444/

In this episode, Grady and Garrett talk about some of the diabetic obstacles that they have been working through in the last few months. And we announce the end of season one.   

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Time Stamps

0:25 - Introduction: Checking in with Grady (Handling the AZ heat, inconsistent schedule, HIIT workouts

 

17:31 - Checking in with Garrett (training for a marathon in the heat, connecting with more Diabuddies    34:06 - Big Announcement

In this episode, Dr. Grady and Dr. Garrett discuss the daily mental and emotional burden that a type 1 diabetic goes through. This is a great episode to have your non-diabetic friends and family member listen to to get an idea of what you go through on a daily basis.

 

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Time Stamps

0:25 - Introduction: Being Called A “Bad Diabetic”

11:11 - The Mental Burden of constantly thinking about your diabetes

17:40 - The Struggle of venting to a Non-diabetic

22:25 - The Fear of Life (foods, exercise, daily activities)

25:17 - The Emotional Tax of Diabetes

40:02 - You are not your number/Chasing Perfection

47:10 - Our Mindset to Take on Diabetes

58:25 - Diabetic WIN

 

In this episode, Dr. Donohoe and Dr. Panno review a research paper that summarizes insulin's role in the brain and the connection between insulin resistance and Alzheimer's disease. Guess what? INSULIN IS NOT ONLY FOR GETTING GLUCOSE INTO THE CELLS!! 

The Paper Discussed in this Podcast:

Blazquez, E., Velazquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, JM., (2014). Insulin in the Brain: it’s pathophysiological implications for states related to central insulin resistance, type 2 diabetes, and Alzheimer’s disease. Frontiers in Endocrinology; 5(151). Doi: 10.3389/fendo.2015.00161.

 

 

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Time Stamps

0:25 - Introduction: Big takeaways and Major questions that this paper addresses and generates

8:18 - Glut Transporters in the brain

12:22 - Functions of Insulin in the Brain: Memory and learning

20:47 - Functions of Insulin in the Brain: Neuroprotection

28:13 - Production and Regulation of Insulin in the Brain

42:36 - Why are these things not being talked about more in the medical community?

48:23 - Alzheimer's and Diabetes Connection

58:42 - Burst My Beta Cells

 

In this episode, Dr. Grady and Dr. Garrett discuss the benefits of having the plethora of data that a CGM can give you, but not just for T1Ds but also for Type 2 Diabetics and NON-diabetics as well. We also get into what the costs of these devices cost and what that might look like in a healthcare setting for a type 2 diabetic or a non-diabetic looking to optimize their metabolic health. 

 

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Time Stamps

0:25 - Introduction: Why Are CGMs Useful?

5:05 - Why would a type 2 diabetic want to use a CGM?

15:35 - Who needs a CGM and who should get a CGM

23:25 - Using the CGM to tailor your care more specifically to what works for you

25:43 - How expensive are CGMs

38:21 - Are CGMs useful for non-diabetics?

 

In this episode, Dr. Grady and Dr. Garrett have the pleasure of interviewing a truly inspiring T1D Don Muchow. Don recently completed a run across America (Disneyland to Disney World)!! We dive deep into the nitty-gritty of how he was able to accomplish such a journey as a diabetic. What challenges he faced and how he overcame them and his passion for helping T1Ds overcome the fear of exercising for fear of lows. 

If you would like to learn more about Don's run you can visit his website which has a detailed account of the entire journey. 

https://t1determined.org/

If you would like to contact Don you can email him at: donsolo@t1determined.org

 

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 Time Stamps

0:25 - Introduction: How Did You Decide To Run From Disneyland To Disney World?

3:47 - How and why did you start running in your 40s?

11:16 - How Don handles “stress” high blood sugars

14:20 - What diabetic tech do you use to accomplish and ultra run successfully

20:44 - Glucagon (The Liquid Wall) - Don’s Experience with glucagon during a long run

29:38 - What is it like to run across the country?

42:27 - Having ZERO scary lows while running across country and safely managing highs

50:30 - Overcoming the fear of exercise as a diabetic and living with diabetes, not against it.

1:00:42 - What was it like growing up with diabetes in the 70s?

1:07:03 - The tough job of managing diabetes despite having today’s technology

1:12:06 - The specifics of setting a transcontinental record

1:18:13 - What is next for Don? And closing remarks.