Dr. Mike Todorovic, medical educator and science communicator extraordinaire, joins The Curious Clinicians to discuss the Na+/K+ ATPase pump ("the most important enzyme in the human body") and his approach to digital medical education.

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Dr. Matt & Dr. Mike's podcast: https://drmattdrmike.com.au/dr-matt-mikes-medical-podcast/

Dr. Matt & Dr. Mike's YouTube channel: https://www.youtube.com/@DrMattDrMike/featured

This week, the Curious Clinicians return to the topic of episode 72, "Bringing up Beethoven" with a surprising news update and new perspectives on a 200 year old tale!

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

In this episode from our archives, originally posted on September 16, 2020, The Curious Clinicians examined why the savory flavor umami is SO DELICIOUS. Dig in!

Show notes: https://curiousclinicians.com/2020/09/16/episode-9-why-is-umami-so-delicious/

CME: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

Audio edited by Clair Morgan of Nodderly

This is the first in a series where Hannah explores clinical questions that have arisen during her intern year. In this episode, The Curious Clinicians learn why acetaminophen toxicity can lead to an anion gap metabolic acidosis. 

Don't forget, you can obtain CE/MOC credits just for listening!

To learn more, check out the show notes for this episode on our website.

Avi, Tony, and Hannah are back at it, investigating why metronidazole treats both bacterial and parasitic infections, why it's only effective against anaerobic organisms, and how this relates to the supposed disulfiram-like reaction. 

The episode opens with an important message from Dr. Mark Shapiro (host of the Explore The Space podcast) about VoteHealth 2020.

Here are some links for obtaining CE/MOC credits just for listening to this episode and to read the show notes on our website.

You can also check out Avi's original tweetorial on metronidazole and all of The Curious Clinician Podcast's other episodes.

Hannah, Tony, and Avi dig into the origins and mechanism of that most wondrous of flavors: umami. 

Show notes: https://curiousclinicians.com/?p=722

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

The Curious Clinicians examine why coronary ischemia can present with dyspnea.

Show notes: https://curiousclinicians.com/?p=888

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

The Curious Clinicians dive into the history and physiologic effects of IV fluids and why saline is definitely not "normal".

Show notes: https://curiousclinicians.com/?p=824

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

Avi, Hannah, and Tony investigate why the antibiotic azithromycin has anti-inflammatory properties. 

Show notes: https://curiousclinicians.com/?p=741

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Tony, Avi, and Hannah examine the mechanisms of contraction alkalosis as a result of diuretic use, as well as the roles of chloride and a protein that none of them had previously heard of: pendrin.

Show notes: http://curiousclinicians.com/?p=788

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Hannah, Tony, and Avi dive into the health and art of Vincent Van Gogh. Was he treated with digitalis? Was he "dig toxic" and did this influence his color palette? 

Show notes: https://curiousclinicians.com/?p=311

CE/MOC: https://vcu.cloud-cme.com/default.aspx?p=4000&curriculum=Curious%20Clinicians

On this episode of the The Curious Clinicians, Tony, Avi, and Hannah explore why trimethoprim/sulfamethoxazole can cause an isolated rise in creatinine. 

Show notes: http://curiousclinicians.com/?p=561

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Hannah, Avi, and Tony break down why cancer leads to a hypercoagulable state, recalling the story of Armand Trousseau and exploring the roles of tissue factor and evading the immune system. 

Show notes: https://curiousclinicians.com/?p=304

CE/MOC: https://vcu.cloud-cme.com/default.aspx?P=0&EID=18166

The Curious Clinicians are on tap to ask, why does chronic alcohol use cause macrocytosis?

Read the show notes here. 

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

Do you miss digging into the "why" behind what we do every day in medicine? Join Hannah, Tony, and Avi in The Curious Clinicians podcast as they delve into "why", starting with episode 1: Why does fingernail clubbing happen in so many different diseases?

Show notes: https://curiousclinicians.com/?p=481

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

In this preview of The Curious Clinicians, we provide an introduction to the podcast and a sneak peak at Episode 1! The full episode will be released June 3rd. 

Welcome to NephMadness 2024! In collaboration with Things We Do For No Reason (TWDFNR), we are excited to promote the start of this amazing medical education opportunity.

Inspired by the "March Madness" college basketball tournament, NephMadness is a "a free online, CME-granting, evidenced-based, noncommercial learning initiative that leverages the tools of social media to teach about the latest and greatest breakthroughs in the field of nephrology!". Fill out your bracket today!

Dr. Jeff Kott, NephMadness Executive Committee member, Critical Care Medicine Fellow At Stony Brook Medicine on Long Island, NY and former nephrology fellow at Mount Sinai Hospital in Manhattan, joins Avi, Hannah, and Tony to discuss two hot button TWDFNR topics in nephrology:

1. Whether we should use phosphate binders in acute kidney injury
2. If the urine anion gap in non-gap metabolic acidosis is helpful or not

Read the show notes here.

Audio edited by Clair Morgan of Nodderly.com. 

The Curious Clinicians examine why the genetic mutations leading to hereditary hemochromatosis might have offered an evolutionarily advantage to our Neolithic ancestors. The answer relates to an old breakfast stalwart- cereal and milk!

Read the show notes here.

Audio edited by Clair Morgan of Nodderly.com. 

This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. 

On this episode from our archive, originally posted on March 15, 2022, The Curious Clinicians examine why cirrhosis predisposes to SBP, and why bacterial translocation across the bowel wall into ascites doesn't actually occur!

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of nodderly.com.

This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. 

The Curious Clinicians investigate the history and mechanisms of how thalidomide caused embryopathy in the late 1950s and early 1960s in over 10,000 babies across the world.

Read the show notes here. 

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. 

On this episode from our archive, originally posted on February 16, 2022, The Curious Clinicians investigate why antiphospholipid antibodies can be falsely positive during acute illness or thrombosis.

Read the show notes here. 

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode is sponsored by Audible! New members can try Audible free for 30 days using our own Curious Clinicians podcast code - visit Audible.com/TCCPOD or text TCCPOD to 500-500. 

In this episode, we investigate the reasons why we don't (and don't need to) transfuse to normal hemoglobin levels.

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Our producer is medical student Giancarlo Buonomo.

The Curious Clinicians are currently on a holiday break, but we'll be back with new content in 2024!

In the meantime, we hope you enjoy this episode from our archive, originally posted December 10, 2022. We told the story of a tiny carbohydrate called alpha-gal, delving into unsettling meat allergies after tick bites, ancient viruses, allergic reactions to an anti-cancer antibody, and xenotransplantation.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

In this episode, we examine how sickle cell trait protects against malaria, in multiple ways.

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Our producer is medical student Giancarlo Buonomo.

This week, the Curious Clinicians give a 'hot take' on a common symptoms: why do hot flashes occur?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Today we reach back into The Curious Clinicians archives, just in time for Thanksgiving. In this episode, originally posted in November 2021, Hannah, Avi, and Tony examine whether tryptophan from turkey actually causes the infamous Thanksgiving food coma. The answer might surprise you...

Check out the episode's show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of nodderly.com.

In this episode, we explore why ACE inhibitors treat scleroderma renal crisis so effectively (and why bilateral nephrectomy used to be the treatment of choice…).

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

We'd like to welcome the newest member of our team, Giancarlo Buonomo, a medical student who is joining on as a producer!

In this episode, The Curious Clinicians ask why a ketogenic diet can help control seizures in refractory epilepsy?

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

For this episode, The Curious Clinicians ask why patients with bioprosthetic heart valves don't require immunosuppression?

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

On this episode, The Curious Clinicians learn about why hyperthyroidism is associated with atrial fibrillation.

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

On this episode, The Curious Clinicians explore the liver's incredible ability to regenerate after injury or resection.  

Read the show notes on our website here. And subscribe to our new Substack!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode was sponsored by Brooklinen! Use promo code "CURIOUS" for $20 off your first order + free shipping.

This week, The Curious Clinicians are bringing back an episode from the archive that was originally posted in December, 2021.

Tony joined Dr. Adam Rodman as a guest on the Bedside Rounds podcast. We were thrilled to share that episode here. 

How can we medically tell whether or not someone is alive or dead? The answer is more complicated than you'd think. This episode was a live podcast Adam and Tony gave at the Massachusetts Chapter of the American College of Physicians annual meeting on October 16, 2021. They track the evolution and controversies of the death exam, from a trans-Atlantic scandal surrounding a possible vivisection, a 19th century "X-prize" to determine a technology that could diagnose death, the important distinction between "permanent" and irreversible, and the mysterious Lazarus phenomenon.

Link to episode page: http://bedside-rounds.org/episode-65-the-last-breath/

On this episode, The Curious Clinicians investigate why alcohol both causes a burning sensation when you first swallow it (hint: the mechanism has something to do with chili peppers) and why you get a general sense of total body warmth within the next few minutes. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode was sponsored by Brooklinen! Use promo code "CURIOUS" for $20 off your first order + free shipping.

On this episode, The Curious Clinicians examine an intriguing question - why are babies protected from infection and colitis by C. Diff? We'll touch on factors relating to immunology, microbiology and human development.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

On this episode, The Curious Clinicians are joined by Dr Christopher Worsham, co-author of a fascinating and insightful new book, Random Acts of Medicine, which explores the use of natural experiments to better understand healthcare and is now out in hardcover!

Audio edited by Clair Morgan of Nodderly.com.

Producer Giancarlo Buonomo joins the Curious Clinicians this week to answer a morning report musing: why do we use IV PPIs to treat upper GI bleeding?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

This week, we reach back into the archive for an episode from 2021 (the first in a two-part series related to the eyes) where Tony, Hannah, and Avi explored why Wilson disease can present with Kayser-Fleischer corneal rings. 

Remember to pick up CME/MOC credit just for listening to the episode! 

Check out the show notes for this episode and read Avi's tweetorial on this topic. 

Audio edited by Clair Morgan of Nodderly.com

On this episode, The Curious Clinicians dive into musical history, examining what might have caused German composer Ludwig van Beethoven's infamous deafness.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

In this episode, The Curious Clinicians learn about why pneumonia takes weeks to resolve on chest x-ray, whereas symptoms generally resolve much sooner.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode originally aired April, 2021, where The Curious Clinicians examined why some patients feel short of breath specifically when bending over, aka "bendopnea". 

You can read the show notes for this episode on our website. 

Don't forget to pick up CME/MOC credits, courtesy of VCU Health.

Audio edited by Clair Morgan of Nodderly.

In this episode, The Curious Clinicians examine why upper gastrointestinal bleeding raises BUN. The answer involves experiments where participants were asked to drink blood (!) and the 700 sextillion (7 x 1023) amino acids that comprise the hemoglobin content in a liter of blood. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode was sponsored by Green Chef!

In this episode, The Curious Clinicians tackle why alpha-1 antitrypsin deficiency can cause chronic liver disease. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode is sponsored by BetterHelp! You can give online therapy a try at betterhelp.com/CLINICIANS.

In this episode, The Curious Clinicians investigate whether atrial fibrillation should be considered a risk factor for PE. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode was sponsored by Green Chef!

In this episode, The Curious Clinicians investigate the mysterious blood brain barrier, and how dexamethasone has a seemingly miraculous ability to treat cerebral edema caused by brain tumors. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode is sponsored by BetterHelp! You can give online therapy a try at betterhelp.com/CLINICIANS.

In this episode, The Curious Clinicians investigate why tricuspid valve endocarditis is more common in persons who inject IV drugs.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

In this episode, The Curious Clinicians take things to heart and unpack both why rheumatic heart disease so often involves heart valves, and why the mitral valve is by far the most commonly affected.

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode is sponsored by BetterHelp! You can give online therapy a try at betterhelp.com/CLINICIANS.

Instead of "Why do we...?" this week the Curious Clinicians answer a "Why don't we?" question: why don't we use steroids in acute pancreatitis?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

In this episode, The Curious Clinicians investigate why meperidine treats rigors. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode is sponsored by BetterHelp! You can give online therapy a try at betterhelp.com/CLINICIANS.

In this episode, The Curious Clinicians examine why weight training increases muscle size. 

Read the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com.

This episode was sponsored by Green Chef!

The Curious Clinicians took a quick holiday break and will be back with new episodes next week!

This episode, originally posted May, 2022, explores why obstructive sleep apnea can cause nocturia.

Check out the show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of nodderly.com.