The Biorevolution Podcast with Andreas Horchler and Louise von Stechow – father and daughter, journalist and biologist, talking about the technologies of the biorevolution. Can genetic engineering, synthetic biology, and artificial intelligence save humanity from disease, climate change, and overpopulation, or are these technologies the first step towards its downfall?
Content and Editing:
Louise von Stechow and Andreas Horchler
Disclaimer:
Louise von Stechow, Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics but do not claim to give medical, investment, or life advice in the podcast.
Learn more about the future of biotech in our podcasts and keynotes. Contact us here:
scientific communication: https://science-tales.com/
Podcasts: https://www.podcon.de/
Image: Kelly Sikkema via Unsplash
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The future of medicine - trends, technologies and skills
Monday, September 2, 2024 • Duration 30:52
How will the medicine of the future look? Healthcare and medicine are on the verge of transformative change, driven by new technologies such as artificial intelligence, telemedicine, and wearable devices. Alongside the technologization and virtualization of medicine, there is a shift from reactive "fix the broken" approaches to preventative strategies and from one-size-fits-all treatments to personalized medicine.
In this future, human healthcare professionals and machines will work hand-in-hand to deliver the best possible care, with empowered patients acting as equal decision-makers who understand and access their own healthcare data. However, a darker scenario could see medicine becoming fully industrialized and dehumanized.
In episode 26 of We’re Doomed, We’re Saved, Andreas Horchler and Louise von Stechow outline the key trends shaping the future of medicine and discuss the opportunities and risks that accompany these developments.
Content and Editing:
Louise von Stechow and Andreas Horchler
Disclaimer:
Louise von Stechow & Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.
Learn more about the future of biotech in our podcasts and keynotes. Contact us here:
scientific communication: https://science-tales.com/
Podcasts: https://www.podcon.de/
Keynotes: https://www.zukunftsinstitut.de/louise-von-stechow
Image:
alexander-sinn-KgLtFCgfC28-unsplash via Unsplash
References:
https://www.nature.com/articles/s41591-019-0693-y?fbclid=IwZXh0bgNhZW0CMTAAAR0RAb4UU5v5896AQfVNYfdCpLi80iN7JwoZux55ffxyI9W7TMsqVPakS3M_aem_49GYkWynL_l8fmMWXq_Xlg
https://www.zukunftsinstitut.de/zukunftsthemen/megatrend-gesundheit
https://www.nature.com/articles/s41591-024-03097-1#Sec9
https://www.nature.com/articles/s41591-023-02700-1
https://ai.nejm.org/doi/full/10.1056/AIcs2300145
https://www.nature.com/articles/s41599-022-01451-7
https://www.nejm.org/doi/10.1056/NEJMra2215899?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
https://www.imperial.ac.uk/news/167866/information-handling-some-health-apps-secure/
https://journals.sagepub.com/doi/full/10.1177/1357633X211022907
https://www.mckinsey.com/industries/life-sciences/our-insights/germanys-e-health-infrastructure-strengthens-but-digital-uptake-is-lagging
https://www.mckinsey.com/industries/life-sciences/our-insights/german-e-health-offerings-expand-but-adoption-remains-uneven
https://empeek.com/insights/everything-about-telemedicine-statistics-usage-trends/
https://blogs.deloitte.co.uk/health/2023/11/the-future-of-health-in-europe-digital-equitable-sustainable.html
https://www2.deloitte.com/content/dam/Deloitte/uk/Documents/life-sciences-health-care/deloitte-uk-shaping-the-future-of-european-healthcare.pdf
https://www.nature.com/articles/s41569-021-00522-7
https://web-assets.bcg.com/1e/74/5d14d48346bcb56a79c6e7e7ba0f/bcg-the-future-of-digital-health-2024-jan-2024-1.pdf
Update on LLMs - hope, hype and hallucination
Friday, August 2, 2024 • Duration 37:02
Some 36 months after the release of ChatGPT, the verdict is still out on the role that large language models (LLMs) will play in biotech, pharma, and medicine. On paper, the range of tasks that LLMs can perform in biomedical research and healthcare is vast—excavating relevant information for drug discovery from mountains of scientific literature, designing novel proteins, transcribing doctors' notes, aiding diagnostic decision-making, and acting as patient-facing chatbots.
But given the models’ propensity to hallucinate, we need to define how much error we can tolerate for different LLM use cases in the biomedical fields and create evaluation frameworks that allow us to apply the models confidently. In some cases, it might turn out that the time spent for human supervision of the model will outweigh the efficiency gain.
In episode 25 of We’re doomed we’re saved we talk to idalab founder and mathematician, Paul von Bünau we discuss the promise and challenges of LLMs in the biomedical field and ask the question if we can ever stop them from hallucinating.
Content and Editing:
Louise von Stechow and Andreas Horchler
Disclaimer:
Louise von Stechow & Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.
Learn more about the future of biotech in our podcasts and keynotes. Contact us here:
scientific communication: https://science-tales.com/
Podcasts: https://www.podcon.de/
Keynotes: https://www.zukunftsinstitut.de/louise-von-stechow
Image:
jo-coenen-studio-dries-2-6-yST9mzlMVLQ via Unsplash
References:
Excavating scientific literature
1. https://www.nature.com/articles/s41587-023-01788-7
2. https://idalab.de/insights/how-large-language-models-excavate-crucial-information-to-scale-drug-discovery
3. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00222-6#secsectitle0015
Unburdening Healthcare
1. https://www.nature.com/articles/s41591-023-02700-1
2. https://medium.com/mantisnlp/applications-of-llms-in-patient-care-83e07548dbb1#:~:text=Applications%20of%20LLMs%20in%20Patient%20Care%201%201.,6%206.%20Personalized%20Health%20Plans%20and%20Coaching%20
3. https://www.nature.com/articles/s41591-023-02700-1
4. https://arxiv.org/pdf/2303.16416
5. https://www.nature.com/articles/s41467-024-46411-8
6. https://link.springer.com/article/10.1007/s00330-023-10213-1
7. https://link.springer.com/article/10.1007/s00330-023-10213-1
8. https://link.springer.com/article/10.1007/s00330-023-10213-1
9. https://www.nature.com/articles/s41591-024-03097-1#Sec9
Reading molecular language
1. https://academic.oup.com/bioinformatics/article/36/4/1234/5566506
2. https://arxiv.org/abs/2106.03598
3. https://resources.nvidia.com/en-us-hc-biopharma/hc-solution-overview-5
4. https://www.nature.com/articles/s41592-024-02201-0#author-information
5. https://www.prnewswire.com/news-releases/ginkgo-bioworks-and-google-cloud-partner-to-build-next-generation-ai-platform-for-biological-engineering-and-biosecurity-301912283.html
6. https://www.nature.com/articles/s41598-024-61124-0
7. https://www.nature.com/articles/s41587-022-01618-2
8. https://www.biopharmatrend.com/post/835-14-companies-pioneering-ai-foundation-models-in-pharma-and-biotech/
9. https://www.biorxiv.org/content/10.1101/2023.01.11.523679v1
10. https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-024-05847-x
11. https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-024-05847-x
12. https://arxiv.org/abs/2403.04197
13. https://arxiv.org/abs/2311.07621
Synthetic Biology - Rewriting Life
Wednesday, November 1, 2023 • Duration 40:36
Synthetic biology - the artificial creation of biological molecules, cells, and even organisms - has the potential to revolutionize biotechnology and agriculture, allowing for the creation of novel biomaterials and fuels, opening new opportunities for DNA-based information storage and computation, and even aiding in the exploration and colonization of space. The first synthetic bacterium was created about ten years ago, and since then, the technologies supporting synthetic biology have become faster, cheaper, and more innovative. With the assistance of artificial intelligence, synthetic biology could unlock vast potential, recognized by various industries. Synthetic biology could also enable bad actors to create harmful microbes.
Big data in pharma - From garbage to gold
Monday, October 2, 2023 • Duration 33:25
In our data-heavy age, data becomes a treasure, a currency, a valuable good. This is true especially for the biotech and pharmaceutical industries, where data can inform the development of novel drugs. But should own biomedical data – and where should the lines between privacy and patient benefit be drawn?
In the new episode of We’re doomed, we’re saved, Andreas Horchler and Louise von Stechow discuss new strategies of data sharing and ownership in biomedicine and pharma.
De-extinction - A mammoth project
Monday, September 4, 2023 • Duration 35:07
The rapid spread of humans is causing many species to disappear off the face of the earth – in a so-called mass extinction. Some scientists are trying to reverse this process, by bringing back extinct species, such as the Dodo, the Passenger Pigeon, or the Wolly Mammoth.
In the 14th episode of We’re doomed, we’re saved Andreas Horchler and Louise von Stechow discuss the breeding procedures and genetic engineering techniques that might be used for brining back extinct animals. We also discuss the ethical implications from resource waste to animal welfare – and what it might mean to be the first and the last member of a (de)extinct species.
365 days We're doomed we're saved
Wednesday, August 2, 2023 • Duration 25:36
Ein Jahr We're doomed we're saved - seiten einem Jahr sprechen Andreas Horchler und Louise von Stechow über die Themen der Biorevolution. Wir haben über Anitbiotikaresistenzen, Biowaffen, Gentherapien, Neuroprothesen und AI gesprochen. Wir hatten spannende Gäste, wie den Mathematiker und idalab Gründer Paul von Bünau, und den Forschungs- und Entwicklungschef von Sanofi Adventis Deutschland mit denen wir über die Rolle neuer Technologien wie AI für die Medikamentenentwicklung gesprochen haben.
In dieser Folge lassen wir die erste Staffel Revue passieren und machen "A big announcment". Dies wird unsere vorerst letzte Deutsche Episode sein - in der neuen Staffel, ab September, werden wir uns auf Englisch unterhalten.
Follow the money - Die Geldquellen der Biowissenschaften
Monday, July 3, 2023 • Duration 33:09
Follow the money, folge dem Geld, ist eine alte Weisheit wenn man den Kern einer Angelegenheit verstehen will.
In der 12. Folge von We're doomed we're saved folgen wir diesem Weg zu den Geldquellen der Biomedizinischen Forschung, zu Regierungszuschüssen, großen Pharmaunternehmen und privaten Stiftungen, wie der Bill und Melinda Gates Foundation, die ganze Forschungszweige quasi im Alleingang finanziert. Solche privaten Geldgeber haben besonders in den USA einen großen Einfluss auf die Forschungslandschaft, obwohl ihre Auswahlkriterien und Transparenz umstritten sind und die Verbindung von Wissenschaftlern und reichen Technokraten das Vertrauen in die Wissenschaft verringern kann.
Von und mit Andreas Horchler und Louise von Stechow
Die Zukunft der Pharmaindustrie - Neue Technologien und Modelle
Thursday, June 1, 2023 • Duration 39:16
Wie werden neue Technologien, wie die künstliche Intelligenz die Pharmaindustrie beeinflussen? Welche neuen Modelle werden die Blockbuster der Vergangenheit ablösen?
In dieser Folge sprechen wir mit unserem Gast Professor Jochen Maas, Geschäftsführer Forschung & Entwicklung der Sanofi-Aventis, Deutschland GMBH über die Zukunft der Pharmaindustrie
Biohackers - Die Garagenwissenschaftler
Tuesday, May 2, 2023 • Duration 38:51
Biohacker experimentieren an sich selbst, führen genetische Modifikationen durch, implantieren Mikrochips und testen neue Medikamente. Dabei bewegen sie die Wissenschaft aus den Elfenbeintürmen der Universitäten hin zu privaten Laboren, Küchen und Garagen. Dies verspricht größere Chancengleichheit und neue Möglichkeiten für Innovationen in der Wissenschaft, birgt jedoch auch die Gefahr einer mangelnden Regulierung mit unvorhersehbaren Konsequenzen.
In der neuen Folge von We’re doomed we’re saved besprechen Andreas Horchler und Louise von Stechow die Ziele und Methoden der Biohacker und stellen die Frage ob sie eine Chance ohne eine Gefahr darstellen.
ChatGPT - The rise of the chatbots
Monday, April 3, 2023 • Duration 38:02
ChatGPT, das Large Language Model von OpenAI ist in aller Munde. Von Untergangsszenarien in denen der Mensch und seine Arbeitsleistung als obsolet erklärt werden, über Lehrende, die sich fragen, wie sie Seminararbeiten bewerten sollen, bis hin zur Frage menschlicher und maschineller Kreativität – ChatGPT bewegt uns alle.
In der neuen Folge von We’re doomed we’re saved besprechen Louise von Stechow und Andreas Horchler welche Auswirkungen ChatGPT und andere Large Language Modelle für den Gesundheit Sektor und die Biotech und Pharma Industrie haben könnten und ob sie gar dabei helfen können den Code des Lebens zu verstehen oder sogar umzuschreiben.
Unterstützt werden sie dabei zum ersten Mal von einem Gast, Paul von Bünau, Mathematiker und Gründer der Firma idalab, die sich auf künstliche Intelligenzlösungen für die Biotech Industrie spezialisiert.
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