The Allo Podcast – Details, episodes & analysis

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The Allo Podcast

Allo Hope Foundation

Health & Fitness

Kids & Family

Science

Frequency: 1 episode/22d. Total Eps: 41

The Allo Podcast brings you into the complex world of maternal red blood cell alloimmunization and Hemolytic Disease of the Fetus and Newborn (HDFN.) We share real life patient experiences, valuable insights for providers and care teams, and easy to understand monitoring and treatment information. We empower you to advocate for the best possible care, and we have a great time doing it.

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🇨🇦 Canada - medicine
13/05/2025
#95

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https://allohopefoundation.org/
28 shares
https://allohopefoundation.org/library/terminology/
28 shares
https://www.mediaclub.co/
25 shares

https://www.facebook.com/groups/antibodiesinpregnancy
18 shares
https://www.facebook.com/ONegFoundationKenya/
2 shares

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RSS feed quality

Good

Score global : 78%

Publication history

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From Tragedy to Triumph: Closing Amanda’s Story and Celebrating Allo Hope

Season 3 · Episode 12

Tuesday, January 21, 2025 • Duration 01:43:32

Bethany and Molly close out Amanda’s incredible survival story that began in Episode 2 of this season (Low Titer Pregnancies). After a rapid increase in titers from too low to titer to 2,048, Amanda’s referral to an MFM team went unnoticed for a few weeks. By the time she was seen, her son was very sick, but he was in the right hands with Dr. Snowise and his team. Listen to this miraculous story unfold.

Then, Bethany and Molly reflect on AHF’s accomplishments and goals for the year and close with a powerful reflection that will touch the hearts of every listener, ending with a special dedication.

References in this episode:

Nipocalimab trial results: Nipocalimab

Use of cffDNA to find fetal antigen status for D, E, C, c, K, Fya: Fetal Antigen Study

ESAs for newborns with HDFN to reduce the number of transfusions: Transfusion Reduction

Donate to AHF: Allo Hope Donate

AHF Merch: Allo Hope Merch

Watch this episode on YouTube: Allo Hope on YouTube

Join the AHF patient support group:

AHF Support Facebook

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S3E11 The Impact of Alloimmunization on Parenthood

Season 3 · Episode 11

Tuesday, January 14, 2025 • Duration 01:04:18

Bethany, Katie and Molly talk together about how their parenting is affected during and after the life-changing experience of an alloimmunized pregnancy.

Donate to AHF: Allo Hope Donate

AHF Merch: Allo Hope Merch

Watch this episode on YouTube: Allo Hope on YouTube

Join the AHF patient support group:

AHF Support Facebook

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What You Need to Know About Low Titer Pregnancies

Season 3 · Episode 2

Tuesday, November 12, 2024 • Duration 01:09:56

S3E2: Low Titer Alloimmunized Pregnancies

Over half of alloimmunized pregnancies begin with a low antibody titer, and a portion stay low throughout the pregnancy. Others begin low and later rise to critical levels. This episode is dedicated to management of the low titer pregnancy and how to anticipate a potential change in disease trajectory if titers increase.

Bethany and Molly include management recommendations and stories submitted by low titer moms before transitioning to a special interview with allo mom Amanda, whose pregnancy began as a low titer pregnancy before taking a surprising turn. We meet Amanda in this episode before resuming the second half of her HDFN journey in this season’s final episode, Incredible HDFN Survival Stories.

Key aspects of low titer disease management:

Determine baby’s antigen status if possible. If not possible, monitor as if antigen positive. If the baby is certainly antigen negative, the pregnancy proceeds as normal and there is no need to do anything further beyond standard pregnancy care
Establish care with an MFM and determine up front if this MFM is able to do IUTs on your baby if your disease progresses. If not, have a referral plan set up
Check titers every 4 weeks in the first and second trimester, then every 2 in the third trimester
Weekly fetal assessment beginning at 32 weeks (Nonstress tests and biophysical profiles).
Delivery at 37-38 weeks
Follow all neonatal recommendations (establish a plan with pediatrician in advance if possible b/c they are likely to be doing the follow-up care) - bilirubin consistent with AAP guidelines which may include daily testing after discharge for a week or more, and hemoglobin/hematocrit weekly for the first six weeks and until hemoglobin/hematocrit increases or is in stable normal range for two consecutive weeks

Delivery timing 37-38 weeks: ACOG Medically Indicated Late Term and Early Preterm Deliveries. ACOG Early Delivery Guidlines

The Essential 5 Key Steps to Help HDFN Babies Thrive

Season 3 · Episode 1

Tuesday, November 5, 2024 • Duration 37:19

S3E1: Top 5 Things to Save HDFN Babies

Bethany and Molly begin Season 3 with a review of the episodes ahead before challenging each other to list what they think are Top 5 things that would keep the most HDFN babies safe. The episode takes a turn when they reveal that they have signed themselves up for plenty more than 5 things (listed below).

Donate to AHF: https://allohopefoundation.org/get-involved/donate/

AHF Merch: https://allo-hope-foundation.myspreadshop.com/

Watch this episode on YouTube:YouTube The Essential 5

Join the AHF patient support group: https://www.facebook.com/groups/antibodiesinpregnancy

Top 5 Prenatal Things (in no particular order):

Bethany:

Quick referral to MFM (and a list of MFMs worldwide who specialize in treating alloimmunized pregnancies)
Preventative medications accessible to all women who need them (Rh immune globulin/RhoGAM; intravenous immune globulin, plasmapheresis for severely affected pregnancies)
Weekly, accurate MCA scans beginning at 16-17 weeks for those with critical titers or previously affected babies; for those with early onset severe disease, starting sooner
MFMs who collaborate with other experts and refer when necessary
IUTs performed on time, using fetal paralytic meds, by providers with ample experience performing IUTs who know to space and attempt the last IUT at 34-35 weeks if possible
(Honorable mention): Referring all women with positive antibody screen to Allo Hope Foundation
(Honorable mention): Delivery at 37-38 weeks unless you are certain baby is antigen negative

Allo Hope Podcast Season 3 Announcment

Season 3

Friday, November 1, 2024 • Duration 01:45

The Allo Podcast is back for a third season! This season features:

New stories of survival in the most critical of medical situations.
Conversations with MFM Dr Kara Markham and Neonatal Specialist Dr Tim Bahr.
New information about medical advancements in the treatment of HDFN.
A live gender reveal from one of the podcast’s previous guests.
And, of course, Bethany Weathersby and Molly Sherwood are back to brighten your day.

New episodes begin streaming on Tuesday November 5th. So, shine up your earbuds, get ready to be inspired and empowered, and follow the Allo Podcast wherever fine podcasts are streamed. Or, if you’re looking for some smiling faces and the occasional teary eye, join us over on YouTube.

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Vital HDFN Treatments & Cutting Edge Research with Dr. Ken Moise

Season 2 · Episode 12

Tuesday, November 28, 2023 • Duration 01:20:36

Over the Past 2 seasons Bethany and Molly have discussed the lack of consistent, accessible treatment and the current ways we can treat an alloimmunized mom and her children with HDFN, but on this episode with Dr. Moise we discuss a bright future. Can a simple carbon monoxide reader replace a needle procedure to monitor for anemia? Can a drug stop antibodies from crossing the placenta entirely? We look to the cutting edge of medical treatment for disease that brought these women together.

Guest: Dr. Kenneth J Moise Jr, M.D. Dell Medical School – UT Austin
Director, Comprehensive Fetal Care Center Dell Children’s Medical Center

DONATE TO AHF AFRICA

Episode Topics:

Severity of subsequent alloimmunized pregnancies
IVIG and importance of timely treatment
Ideal newborn management of HDFN
Antibody-specific differences in newborn HDFN presentation
Erythropoietin to prevent or delay need for neonatal transfusion
Cell free fetal DNA (cffDNA) (Billion To One’s Unity Screen) for fetal antigen typing instead of amniocentesis
Exhaled carbon monoxide to monitor for newborn anemia
Nipocalimab trial update
State of alloimmunization/HDFN in Africa
What can you do to help?

Links:

Rose's Story part 2

Season 2 · Episode 11

Tuesday, November 21, 2023 • Duration 01:32:24

Continuing from last episode, Bethany and Molly listen to Rose Murage’s story. As Rose navigates the final few steps to the United States, she discovers that both the lack of quality care in Kenya and the trauma of her previous pregnancies will follow her to America. But tears of sorrow become tears of joy when she is finally in the hands of a provider who can offer empathetic, quality care, and the world and the podcast welcomes baby Lucas.

Episode themes:

Traveling to another country to receive care for alloimmunization/HDFN
Severe HDFN
MCA Doppler ultrasound to monitor for fetal anemia
Intrauterine blood transfusion (IUT)
Emergency c-section
NICU experience with HDFN baby
Welcoming a miracle while coping with the grief of previous loss
Hope

What can you do as a listener?

Please donate to the AHF Africa program. An antibody screen in Kenya costs $5, but most families cannot afford this additional expense. We need $12,000 a year to sustain this program. Learn more about what we do with your donations and make a donation here. Anyone who contributes a $50/month recurring donation will receive quarterly e-mail updates directly from Rose, AHF’s Ambassador to Kenya.
Join O Negative Foundation Kenya if you live in Kenya and have a negative blood type.
Follow or donate to Rhesus Solution Initiative, a Nigerian NGO dedicated to educating women about their blood type and providing access to Rh immune globulin to prevent alloimmunization.

Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org

The Allo Podcast is produced and edited by https://www.mediaclub.co.

Rose's Story part 1

Season 2 · Episode 10

Tuesday, November 14, 2023 • Duration 01:39:44

This special two-part episode of the Allo Podcast is intended for our regular listeners and for those who are unfamiliar with alloimmunization. A beautiful testament to the grace of humanity, Bethany and Molly sit on the floor of Molly’s bedroom with guest Rose Murage, a native Kenyan with a harrowing pregnancy journey. Rose shares the pain of watching her first two children die tragic, inexplicable deaths. But when Rose reached out to Bethany for help, a new journey began to diagnose Rose with red cell alloimmunization and find a way towards a living baby in a country with limited resources. Join us for the first part of Rose’s story as she tells of her life in Kenya, the short physical lives of Alexis and Max, the obstacles she overcame to seek treatment, and the gift of an American doctor and a network of activists to heal a family.

Definitions for the show notes as they appear in the episode:

Rhogam shot/Rh immune globulin/Anti-D injection: An injection for Rh negative women to help prevent them from developing Anti-D antibodies during pregnancy. This needs to be administered after pregnancy bleeding, at 28 weeks, and after birth. Access to this injection is limited in developing countries and often not affordable for the average family.
ICT test: Indirect Coombs Test, a blood draw on the mother to see if she has red cell antibodies (alloimmunization) which can attack her baby's blood and cause HDFN. This is also called an antibody screen.
DCT test: Direct Coombs Test, a blood test that is run on babies after birth to see if mom's antibodies are attaching to their blood cells. A baby with a positive DCT usually means they have hemolytic disease of the fetus and newborn (HDFN).
MCA Doppler scan: Specialized ultrasounds that detect fetal anemia. This is the best way to monitor a baby at risk for HDFN to determine if they need an intrauterine blood transfusion to treat their anemia. An MCA value of 1.0 is normal, and 1.5 means the baby is anemic and needs a transfusion. In Kenya, very few hospitals can conduct these MCA Doppler ultrasounds accurately.
IUT: Intrauterine transfusion, currently the only way to treat a baby with HDFN in utero. This is a blood transfusion into the baby's umbilical vein using a long needle through the mother's abdomen.
Rhesus positive: This means that a person has a positive blood type (D antigen positive). Rose's body is Rhesus negative and makes antibodies to Rhesus positive (D antigen positive) blood. Any donors for her baby would need to be Rhesus negative so that her antibodies do not destroy the newly donated blood.

Agne's Story

Season 2 · Episode 9

Tuesday, November 7, 2023 • Duration 01:07:32

Agne’s experience of growing up in the Soviet Union has left her with a vague medical record that doesn’t explain her severe antibody titer affecting her pregnancies. Bethany and Molly experience the culture shock of Agne’s uncommon options following the loss of her first child to a failed intrauterine blood transfusion, followed by two more unthinkable losses as she searches for the information she needs to have her rainbow baby even when it feels impossible.

Show Themes:

Alloimmunization and HDFN treatments in Eastern Europe
Parental antigen and antibody status testing
Conflicting issues between social views and medical treatment
Social customs on discussing loss and pregnancy complications
Experiencing the Nipocalimab trial in Belgium

References:

Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.

The Allo Podcast is produced and edited by Media Club.

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Processing Grief & Trauma in Alloimmunized Pregnancies

Season 2 · Episode 8

Tuesday, October 31, 2023 • Duration 57:59

A powerful episode that you may not know you needed. Bethany and Molly share from the heart in this special episode that will open you up to an awareness and understanding you may not have considered before. Grief and trauma are more common than you think across the motherhood journey, but especially in pregnancies affected by alloimmunization. This episode is intended for any listener who has experienced loss related to pregnancy and motherhood, no matter how big or small, and for those who want to better support a person who has experienced pregnancy trauma and grief. Bethany and Molly share about grief from the loss of a child, and also grief from the loss of expectations, loss of trust, loss of hope for what pregnancy and motherhood would feel like. With the help of insights from previous guests, they discuss a path toward hope and healing the wounds we suffer with loss of a child, the burden of high risk pregnancy, and how to honor our losses.

Show Themes:

Defining trauma and grief: it’s more than pregnancy loss
Identifying the types of trauma with this disease
How to find support in times of need
Specific coping tips for loss and grief
How to support a person who has lost a child
Finding hope in the darkest moments

Links:

Why high risk pregnancy causes trauma
Articles on Losing Lucy and Finding Hope
Books on finding hope and accepting grief
- “A Grace Disguised” by Jerry Sittser
- “An Exact Replica of a Figment of my Imagination” by Elizabeth McCracken
- “A Grief Observed” by CS Lewis
- “I Will Carry You” by Angie Smith
- “A Path through Suffering” by Elisabeth Elliott
Effectiveness of a counseling intervention after a traumatic childbirth: a randomized controlled trial

If you or a loved one are having thoughts of suicide contact your national suicide prevention hotline

The Allo Podcast – Details, episodes & analysis

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The Allo Podcast – Details, episodes & analysis

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