Great science doesn't happen in a vacuum — it happens at universities, in labs, and in the minds of researchers who've dedicated their lives to solving problems that matter. At the fifty-third degree of latitude, the University of Alberta is home to some of the world's most compelling scientific work. And most people have never heard of it.
Science at the Fifty-Third Degree changes that.
Hosted by Dr. Nayiar Shahid, each episode takes a deep dive into a single piece of research — exploring not just the science itself, but the human story behind it. The questions being asked. The methods being used. And what the answers might one day mean for the rest of us.
From the molecular machinery of a healing heart to the cutting edge of fields you didn't know existed, this is science made accessible, personal, and genuinely surprising — one discovery at a time.
New episodes available on the University of Alberta's Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at basicsci@ualberta.ca.
This podcast was recorded and produced at the University of Alberta. The University of Alberta, its buildings, labs and research stations are primarily located on the territory of Néhiyaw (Cree), Niitsitapi (Blackfoot), Métis, Nakoda (Stoney), Dene, Haudenosaunee (Iroquois) and Anishinaabe (Ojibway/Saulteaux), lands that are now known as part of Treaties 6, 7 and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems and cultures of all First Nations, Métis, and Inuit.
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What if wearable technology could do more than track your steps—what if it could listen to radio signals drifting through your bloodstream to monitor your health in real time? In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid sits down with Dr. Peter Light from the Department of Pharmacology at the University of Alberta to explore where pharmacology meets radio waves and artificial intelligence. Dr. Light unpacks two major medical discoveries from his career: why a class of diabetes drugs designed for the kidneys (SGLT2 inhibitors) unexpectedly reduces heart failure events by 40%, and how his lab engineered WaveSense—a needle-free continuous glucose monitor that uses radio frequencies and AI algorithms to measure blood sugar without test strips or consumables. This episode covers: ● The heart-kidney mystery: How SGLT2 inhibitors offer direct cardioprotection even though SGLT2 receptors aren't expressed in the heart. ● How radio frequencies combined with AI match the accuracy of traditional glucose sensors completely non-invasively. ● Fostering intrinsic motivation: How real-time trend visualization helps prevent Type 2 diabetes far better than static finger-prick numbers. ● The "Beyond Glucose" initiative: Adapting radio frequency software to measure other vital blood metabolites like lactate and ketones.
Note: Science at the Fifty-Third Degree is produced by the University of Alberta Basic Science Administrative Team and is available on the Aviary platform and wherever you listen to podcasts. Questions or feedback? Reach us at basicsci@ualberta.ca.
S2E2: Time is on Fly Side
Season 2 · Episode 2
Tuesday, October 6, 2026 • Duration 17:30
Have you ever woken up just moments before your alarm clock goes off, or felt completely undone by jet lag? In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid sits down with Dr. Deniz Top from the Department of Cell Biology at the University of Alberta to explore the molecular clocks that keep our bodies on schedule. Using fruit flies (Drosophila) as a pared-down genetic model, Dr. Top’s lab investigates how genetic mutations and environmental disruptions—like Edmonton's short winter days or blue light exposure—can desynchronize our internal timing and impact mental health. The discussion dives into viewing neural biochemistry as a binary operating system, using firefly genes to watch cellular clocks tick in real time, and why uncoupling clock programs across brain regions may explain complex behavioral disorders. This episode covers: ● How circadian rhythms link to mental health, Seasonal Affective Disorder, and directional jet lag. ● The binary code analogy: viewing biochemical interactions as 1s and 0s driving the brain's operating system. ● Why fruit flies are the ultimate model for circadian neuroscience ● Using firefly luciferase reporters to track tissue-specific clock oscillations in real time. ● Dr. Top's uncoupling hypothesis for behavioral disorders and practical chronobiology tips for daily living.
S1E5: He Can Go His Own Way
Season 1 · Episode 5
Tuesday, June 2, 2026 • Duration 13:35
Science is all about getting a closer look, but instead of diving into a molecule or an organ, this episode zooms in on the person behind the science. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid goes behind the lab bench to explore the journey from student to success with Dr. Martin Munz. Spanning two continents and numerous postings, Dr. Munz shares how he has built a vibrant scientific community around his research on neural circuits. From early work with tadpoles to whole-brain studies in mice, Dr. Munz discusses how key mentorships, early career funding, and a willingness to take high-impact risks have shaped his career. Now establishing his own lab at the University of Alberta with local support from the Stollery Children's Hospital Foundation through the Women's and Children's Health Research Institute (WCHRI), he is pushing the boundaries of neuroscience. This episode covers: ● The story behind his 2014 Science paper investigating how neuronal activity impacts circuit development in Xenopus laevis tadpoles. ● His decision to move to Switzerland for a postdoc in Dr. Boton-Roska’s lab, expanding from retina research into embryonic neocortex development. ● The critical role of early career funding, specifically the Simons Foundation Bridge to Independence Fellowship. ● Transitioning from an experimental postdoc to a professor building a team and working with lab manager Araya at the University of Alberta. ● Navigating a high-risk, high-reward phase of launching ambitious research projects aimed at high-impact publications.
S1E4: Library is a Highway
Season 1 · Episode 4
Tuesday, May 26, 2026 • Duration 14:52
Forget the image of dusty shelves and quiet rooms. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid explores how the modern library has transformed into "mission control" for the information age. Joined by Janice Kung, a professional librarian at the University of Alberta, the discussion dives into the chaotic world of Artificial Intelligence (AI) and the crucial role librarians play as the "superheroes" of information literacy. As AI tools generate "hallucinations" and fake research papers, the challenge for scientists is no longer just finding data, but verifying if it is real. This episode introduces the CARE framework—a vital tool for evaluating AI-generated content—and discusses the ethics of AI in academic publishing. This episode covers: ● The evolution of libraries from analog sanctuaries to digital hubs. ● How AI is changing the way researchers search for and filter data. ● The danger of AI hallucinations and "noise" in scientific literature. ● A breakdown of the CARE framework: Check the source, Analyze the info, Review for bias, and Evaluate accuracy. ● Why AI cannot be a co-author and the importance of human accountability in research.
S1E3: Come Fruit Fly With Me
Season 1 · Episode 3
Tuesday, May 19, 2026 • Duration 14:30
Most people see the fruit fly as a kitchen nuisance or an agricultural menace, but to cancer researchers, Drosophila is a giant in the field. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid talks with Dr. Sarah Hughes, a Medical Genetics professor at the University of Alberta. Dr. Hughes explains why this tiny insect is a foundational tool for human oncology, sharing roughly 75% of human cancer genes. The conversation dives deep into the SNR1 gene (known as SMARCB1 in humans), a critical regulator of chromatin remodeling. When this regulation fails, neural stem cells become "confused," leading to aggressive pediatric brain tumors like Atypical Rhabdoid Tumors (ATRT). This episode covers: ● Why fruit flies are powerful models for human organ systems. ● The role of SNR1/SMARCB1 in stopping proliferation and guiding cell differentiation. ● How "stem-cell-like" cells in the wrong place lead to tumor overgrowth. ● The future of RNA-based therapies to regulate protein production. ● The importance of lab culture and mentorship in driving scientific discovery.
S1E2: The Power of N-of-1
Season 1 · Episode 3
Tuesday, May 12, 2026 • Duration 12:03
What happens when the patient sitting across from you is the only person in the world with their specific condition? In traditional medicine, that's a problem. For Harry Wilton-Clark, it's the whole point. In this episode of Science at the Fifty-Third Degree, host Dr. Nayiar Shahid talks with Harry Wilton-Clark, a researcher at the University of Alberta's Women and Children's Health Research Institute, about a quiet revolution happening at the edges of medicine — the rise of N-of-1 therapies. These are treatments designed not for thousands of patients, but for one. Harry's work focuses on Duchenne muscular dystrophy, a rare and fatal disease that strikes children. Using a technique called exon skipping therapy, his lab designs what he calls "genetic band-aids" — molecules that bind to a specific mutation in a patient's DNA and hide it from the body, allowing it to function more normally. The therapy isn't built for a population. It's built for a child. This episode covers: What Duchenne muscular dystrophy is and why it's so difficult to treat How exon skipping therapy works — and what a "genetic band-aid" actually does Why traditional clinical trials fail rare disease patients — and what N-of-1 trials offer instead How patient families and advocacy organizations are driving research breakthroughs What it felt like when a mouse that wouldn't run — finally ran Why a single patient's treatment could become a master key for thousands of others Harry recently represented Canada at the Falling Walls Lab in Berlin — one of 100 researchers selected from around the world to present work breaking the boundaries of science's biggest problems. The wall he chose to break: the one standing between a child and a cure.