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Episode 29 Gestational Diabetes

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Modern Classical Inspirational Cinematic Motivational Music

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

Answers for Episode 28 Polycystic Ovarian syndrome

Question 1: Diagnosis and Pathophysiology

A 24-year-old woman presents with irregular menstrual cycles and concerns about excessive facial hair. Physical examination reveals mild hirsutism and acne. Laboratory testing shows mildly elevated total testosterone and normal thyroid function. Transvaginal ultrasound reveals 24 follicles in the right ovary and an ovarian volume of 12 mL. Which of the following best explains the underlying pathophysiology of this patient’s condition?

C. Increased luteinizing hormone (LH) secretion and insulin resistance

Question 2: Management

A 29-year-old woman with PCOS and a BMI of 32 kg/m² presents with concerns about infertility. She has been attempting to conceive for 8 months. Her cycles are irregular, occurring every 40–60 days. She is not on any medications. Which of the following is the most appropriate first-line pharmacologic treatment to induce ovulation?

B. Letrozole

Question 3: Long-Term Complications

A 35-year-old woman with a history of PCOS presents for a routine follow-up. She has a BMI of 28 kg/m² and reports daytime fatigue and snoring. Which of the following long-term complications is she at significantly increased risk for, independent of her BMI?

B. Obstructive sleep apnea

Paper for next week:

Geoffrey Hackett, Michael Kirby, Rowland W. Rees, T. Hugh Jones, Asif Muneer,  Mark Livingston, Nick Ossei-Gerning, Janine David, Jeff Foster, Philip A. Kalra, Sudarshan Ramachandran, The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, with Statements for Practice, World J Mens Health 2023 Jul 41(3): 508-537

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 28 Polycystic Ovarian Syndrome

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Science Documentary by Lexin Music 

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO 

Edited by: Todd Fredricks DO

Answers for Episode 27 Metabolic Syndrome

Question 1: Pathophysiology

A 52-year-old male with central obesity, elevated triglycerides, and hypertension is diagnosed with metabolic syndrome. Which of the following best describes the role of free fatty acids (FFAs) in the development of insulin resistance in this condition?

C. FFAs impair insulin signaling by altering the insulin receptor substrate pathway

Question 2: Clinical Biomarkers

Which of the following biomarkers is most consistently decreased in patients with metabolic syndrome and is known for its anti-inflammatory and insulin-sensitizing properties?

C. Adiponectin

Question 3: Diagnostic Criteria

According to the harmonized definition by the International Diabetes Federation and the American Heart Association/NHLBI, which of the following combinations qualifies a patient for a diagnosis of metabolic syndrome?

C. Central obesity, low HDL cholesterol, and elevated blood pressure

Paper for next week:

Thomas A. Buchanan, Anny H. Xiang, Kathleen A. Page, and Richard M. Watanabe, What Is Gestational Diabetes—Really?, Diabetes 2025;74:1037–1046

Important legal things:

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 22 Type 2 Diabetes Mellitus 

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: KI Instrumental (Rock Malmsteen-Style) by Lyrium-2025

Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 21

1.     A 62-year-old man presents with fever, productive cough, and pleuritic chest pain. Chest X-ray reveals a moderate right-sided pleural effusion. Thoracentesis is performed, and pleural fluid analysis shows:

• pH: 6.95
• Glucose: 32 mg/dL
• LDH: 1,200 IU/L
• Gram stain: negative

Which of the following is the most appropriate next step in management?

 C. Insert a chest tube for drainage

2. A 55-year-old woman is admitted with pneumonia and a suspected pleural effusion. A contrast-enhanced chest CT reveals thickened, enhancing visceral and parietal pleura with a fluid collection measuring 35 mm. Which of the following radiologic signs is most consistent with this finding?

 B. Split pleura sign
 
 3.     A 70-year-old man is diagnosed with hospital-acquired empyema. Pleural fluid culture grows methicillin-resistant Staphylococcus aureus (MRSA). According to recent studies, which of the following statements best describes the prognosis associated with this organism?

 C. It is associated with significantly increased 1-year mortality

 Paper for next week

 Giuseppe Maltese, Sybil A McAuley, Steven Trawley, Alan J Sinclair, Ageing well with diabetes: the role of technology, Diabetologia (2024) 67:2085–2102

 Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

 Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

 Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

 Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 21 Pleural Space Infections 

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Survival by ikoliks

Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 20

Question 1: Cardiovascular Risk and OSA

 A 58-year-old man with a BMI of 36 kg/m² presents with excessive daytime sleepiness, loud snoring, and witnessed apneas during sleep. His blood pressure remains elevated despite being on three antihypertensive medications. A sleep study reveals an apnea-hypopnea index (AHI) of 38 events/hour and a mean nocturnal oxygen saturation of 76%.Which of the following findings in this patient is most predictive of increased cardiovascular mortality?

 C. Hypoxic burden

Question 2: OSA and Atrial Fibrillation

 A 65-year-old man with a history of paroxysmal atrial fibrillation (AF) undergoes successful catheter ablation. He returns 3 months later with recurrent palpitations. He reports loud snoring and frequent nighttime awakenings. A sleep study confirms moderate OSA.Which of the following interventions is most likely to reduce the recurrence of atrial fibrillation in this patient?

 C. Continuous positive airway pressure (CPAP) therapy
 

Question 3: Stroke and Sleep Apnea

 A 72-year-old woman is admitted for an acute ischemic stroke. She has no prior history of sleep apnea but reports chronic fatigue and poor sleep quality. Her BMI is 29 kg/m². A sleep study performed during rehabilitation reveals an AHI of 22 events/hour. What is the most appropriate next step in managing this patient’s sleep-disordered breathing?

 C. Initiate CPAP therapy
 

Paper for next week

Ewelina Młynarska , Witold Czarnik , Natasza Dzie˙za , Weronika J˛edraszak , Gabriela Majchrowicz  ,Filip Prusinowski , Magdalena Stabrawa  , Jacek Rysz  and Beata Franczyk,  Type 2 DiabetesMellitus: New Pathogenetic Mechanisms,Treatment and the Most Important Complications, Int. J. Mol. Sci. 2025, 26, 1094

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 20 OSA

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Whip Afro Dance Hall Music by Prazkhanal

Courtesy of Pixabay for non-commercial educational use 

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 19 

Question 1: Diagnosis and Testing

A 28-year-old woman presents with a 2-year history of nasal congestion, sneezing, and watery eyes that worsen in the spring and fall. She has no known food allergies and denies asthma. Physical exam reveals pale, boggy nasal mucosa and allergic shiners. Which of the following is the most appropriate next step to confirm the diagnosis?

 B. Perform skin prick testing
 
 Question 2: Pharmacologic Management

A 35-year-old man with moderate persistent allergic rhinitis has been using cetirizine daily with minimal relief. He reports nasal congestion and postnasal drip that interfere with sleep. What is the most appropriate next step in management?

 C. Start an intranasal corticosteroid
 
 Question 3: Immunotherapy Indications

A 22-year-old college student with seasonal allergic rhinitis has tried intranasal corticosteroids and oral antihistamines with limited benefit. She is interested in a long-term solution. Which of the following is the most appropriate indication for initiating allergen immunotherapy?

 C. Persistent symptoms despite optimal pharmacologic treatment

Paper for next week

Sean P. F. Foley * and John Scott Parrish, Pleural Space Infections, Life 2023, 13, 376.

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 19 Allergic Rhinitis

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Tokyo Café by TVARI

Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 18  

Question 1

A 35-year-old male patient presents with newly diagnosed pulmonary tuberculosis (TB) confirmed to be drug-susceptible (DS-TB). The patient has non-cavitary disease and a low bacillary burden. Based on recent clinical trial evidence and World Health Organization (WHO) guidelines, which of the following treatment regimens is most appropriate for this patient?

 B. 4 months of rifapentine, moxifloxacin, isoniazid, and pyrazinamide
 
 Question 2

A 42-year-old female patient is diagnosed with multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) without fluoroquinolone resistance. The patient has no contraindications to new TB drugs. Based on the most recent WHO recommendations and clinical trial data, which regimen is the preferred treatment option for this patient?

 B. 6 months of bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM)

Question 3

A 50-year-old male patient with pre-extensively drug-resistant tuberculosis (pre-XDR TB, defined as MDR/RR-TB with fluoroquinolone resistance) is being considered for a new treatment regimen. The patient has no baseline resistance to bedaquiline or linezolid. Which of the following regimens, supported by recent clinical trial evidence, is most appropriate, and what is a key consideration for its use?

A. 6–9 months of bedaquiline, linezolid, clofazimine, and delamanid; monitor for linezolid-associated toxicity

Paper for next week

Yerem Yeghiazarians, Hani Jneid, Jeremy R. Tietjens, Susan Redline, Devin L. Brown, Nabil El-Sherif, Reena Mehra, Biykem Bozkurt, Chiadi Ericson Ndumele, Virend K. Somers, Obstructive Sleep Apnea and Cardiovascular Disease A Scientific Statement From the American Heart Association, July 20, 2021 Circulation. 2021;144:

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 18.1  Thoughts on TB

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Intro/Outro: Night Detective by Amaksi

 Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

Rotations is produced (bot not sponsored) using (and we always accept donations from any gear folks):

Rode Podcasters (Pro and Duo)

MacBook Pro

Rode NT1-A mics

Polsen Studio Headphones

Kopul XLR cables

SanDisk media

iPhone 6

Final Cut Pro X

Tama mic stands

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS

Rotations is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

 Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 18 Tuberculosis

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Piano Inspiring by Paul Yudin

Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 17 

Question 1: Antiviral Treatment for Elderly Patient

A 65-year-old man with chronic obstructive pulmonary disease (COPD) presents with a 2-day history of fever, cough, and myalgia. He has been diagnosed with influenza A. Which of the following antivirals is most appropriate for this patient?

 Correct Answer: B. Oseltamivir 

 Question 2: Diagnostic Test for High-Risk Child

A 3-year-old child with asthma has been exposed to influenza and presents with fever, runny nose, and cough. Which diagnostic test is most appropriate for this patient?

Correct Answer: C. RT-PCR 

Question 3: Vaccination Recommendation for Pregnant Patient

A 30-year-old woman at 28 weeks gestation has not received the influenza vaccine. What is the most appropriate recommendation regarding influenza vaccination for this patient?

Correct Answer: C. Administer the inactivated influenza vaccine (IIV) 

Paper for next week

Lana Rosenfield, Paul K. Keith, Jaclyn Quirt, Peter Small, and Anne K. Ellis,

Allergic rhinitis, Allergy, Asthma & Clinical Immunology (2024) 20:74

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 17 Influenza

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 Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Main Title Blockbuster by Mint Music

 Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

Questions and Answers from Episode 16 

Question 1: Diagnosis of Bacterial Acute Rhinosinusitis

A 25-year-old male presents with a 7-day history of nasal congestion, rhinorrhea, and facial pressure. Initially, his symptoms improved after 3 days but then worsened, and he now has a fever of 38.2°C, maxillary sinus tenderness, and purulent nasal discharge. Based on the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2020 guidelines, what is the most likely diagnosis for this patient?

Answer Choices:
C. Bacterial ARS
 
Question 2: Treatment for Viral Acute Rhinosinusitis

A 30-year-old female with a history of allergic rhinitis presents with a 5-day history of nasal congestion and clear rhinorrhea. She has no fever, no facial pain, and her symptoms have not worsened. What is the most appropriate initial treatment for this patient?

C. Saline nasal irrigation

Question 3: Indication for Antibiotics in Acute Rhinosinusitis

Which of the following scenarios indicates the most appropriate use of antibiotics in acute rhinosinusitis (ARS)?

 B. A 10-day history of facial pain, purulent nasal discharge, and fever of 38.5°C
 
 Paper for next week

 Ilaria Motta, Martin Boeree, Dumitru Chesov, Keertan Dheda, Gunar Günther, Charles Robert Horsburgh Jr., Yousra Kherabi, Christoph Lange, Christian Lienhardt, Helen M. McIlleron, Nicholas I. Paton, Helen R. Stagg, Guy Thwaites, Zarir Udwadia, Reinout Van Crevel, Gustavo E. Vel asquez, Robert J. Wilkinson, Lorenzo Guglielmetti, Clinical Microbiology and Infection, 30 (2024) 1107-1114

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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Episode 16 Common Cold

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Intro: Rock Christmas/ Christmas Music by tramp963

Outro: Rainbow by Mood Mode

Courtesy of Pixabay for non-commercial educational use

Produced by: Todd Fredricks DO MSS

Edited by: Todd Fredricks DO MSS

“Who Moved my Cheese,” Spencer Johnson, 1998

https://en.wikipedia.org/wiki/Who_Moved_My_Cheese%3F

Questions and Answers from Episode 15 

Question 1: 

 A 32-year-old healthy female presents to your clinic with a 5-day history of cough that started as dry but has become productive of yellow sputum over the past 2 days. She denies fever or shortness of breath. Her vital signs are normal  and her chest examination reveals no crackles or wheezing. There are no current outbreaks of influenza or COVID-19 in the area. What is the most appropriate management for this patient? 

 D. Reassure the patient that antibiotics are not necessary and provide symptomatic relief 

Question 2: 

 A 68-year-old male with a history of COPD and heart failure presents with cough productive of purulent sputum, fever (38.5°C), shortness of breath on exertion, and pleuritic chest pain for 3 days. His vital signs include a heart rate of 102/min, respiratory rate of 24/min, blood pressure of 110/70 mmHg, and oxygen saturation of 92% on room air. Chest examination reveals crackles in the right lower lobe. After evaluation using clinical prediction tools (CURB-65 score of 1), it is determined that he can be managed as an outpatient. What is the most appropriate antibiotic regimen for this patient? 

 D. Amoxicillin-clavulanate plus azithromycin 

Question 3: 

 A 70-year-old male with hypertension and type 2 diabetes presents to your clinic with a 3-day history of fatigue, cough, headache, and loss of smell (anosmia). He has no shortness of breath or chest pain. His vital signs are stable (temperature 37.2°C, heart rate 88/min), and his oxygen saturation is 96% on room air. A rapid antigen test for SARS-CoV-2 is positive. What is the most appropriate treatment for this patient as an outpatient? 

 B. Ritonavir-boosted nirmatrelvir (Paxlovid)
 

Correct Answer: B 

Paper for next week

Timothy M Uyeki, David S Hui, Maria Zambon, David E Wentworth, Arnold S Monto, Influenza, the lancet, Vol 400 August 27, 2022

Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.

Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.

Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.

Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.