What happens when a bedside question sparks a career that reaches from the lab to public health leadership?
In “Why the Physician-Scientist Career Pathway Still Matters,” host Evan Noch, MD, PhD, talks with Elizabeth “Betsy” Nabel, MD, chair of the Lasker Foundation Board of Directors and advisor to ModeX Therapeutics/OPKO Health, and Rochelle P. Walensky, MD, MPH, professor of medicine at Harvard Medical School and former director of the Centers for Disease Control and Prevention.
Their careers began with very different questions. For Nabel, it was why patients experienced recurrent narrowing of their arteries after angioplasty. For Walensky, it was why lifesaving HIV treatments remained financially out of reach for so many patients. Those questions would lead them into laboratory research, health economics, biotechnology, and leadership at some of the nation's most influential health institutions.
Together, they discuss the mentors and unexpected opportunities that shaped their careers, what it means to be a physician-scientist beyond the traditional academic model, and how to navigate an increasingly uncertain research environment. They also offer candid advice about finding support, reconsidering how physician-scientists are trained, and recognizing the small victories along the way.
Quote of the Episode“Seek the advice of your mentors, but don't be limited by that.”
— Elizabeth “Betsy” Nabel, MD
Key Takeaways
- Let clinical questions guide your research. Nabel recalls how observing high rates of restenosis after coronary angioplasty inspired her to investigate the underlying molecular mechanisms. With support from her department chair, she established a small research laboratory and secured her first NIH R01 grant within 18 months. Walensky's experiences treating patients with HIV similarly led her to study the costs and accessibility of lifesaving therapies.
- There's more than one way to be a physician-scientist. Neither Nabel nor Walensky followed the traditional MD-PhD pathway. Their experiences demonstrate how research careers can extend beyond the laboratory into decision science, public health, government, biotechnology, and health care leadership. Nabel encourages early-career investigators to explore opportunities in biopharma and other settings, even when their mentors' careers have remained entirely in academia.
About the Guests