Explore every episode of the podcast Real Science Exchange-Dairy

The episode opens with Dr. Overton discussing his work at Cornell University and how Dr. Somare came to Cornell from Argentina on a Fulbright scholarship after gaining experience in the feed industry and teaching. Dr. Somare also introduces the poster he is presenting at the meeting. (00:00 – 01:28)

Dr. Somare explains that the study evaluated whether combining zeolite and calcidiol could positively affect mineral metabolism, calcium regulation, and milk performance during early lactation. The study enrolled 92 multiparous Holstein cows in four groups involving either a negative DCAD diet or zeolite feeding, with one group under each strategy receiving calcidiol. The zeolite groups received around 300 g. (02:34 – 04:13)

Looking at the results, Dr. Somare explains how cows were retrospectively classified as dyscalcemic or eucalcemic based on calcium recovery, with dyscalcemic cows remaining below 2.2 millimoles per liter on day four. Dr. Overton notes that previous work used 500 grams of zeolite per day, while the 300-gram dose evaluated here was more economical and appeared to be just as effective. Around 90% of cows fed zeolite during the prepartum period were eucalcemic. (04:14 – 06:27)

Moving into practical application, Dr. Somare describes zeolite as a lower-management strategy compared with negative DCAD diets, which require urine pH monitoring and forage mineral analysis. When asked about dosing, he says the appropriate amount will probably depend on the mineral balance of the diet, but the study achieved good results with 300 grams. (06:28 – 08:09)

Dr. Overton adds that recommendations may move up or down depending on the grams of phosphorus in the diet. He also emphasizes that negative DCAD diets continue to work well and that many herds and nutritionists have extensive experience with them, describing both approaches as viable options. (09:01 – End)

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Controlled vs. uncontrolled inflammation. After introductions, Dr. Rico explains that inflammation is a natural, protective immune response that cows need for processes such as calving. However, it has to stay limited in extent and duration, and it has to resolve properly. Otherwise, it can become uncontrolled inflammation that works against the cow. (00:00 – 07:26)

Are high-producing cows getting what their immune systems need? Next, Dr. Rico asks whether cows get the nutrients needed for a competent immune response as production rises. Building on this, Dr. Fox links chronic inflammation to respiratory disease, liver abscesses, mastitis, lameness and other conditions. He stresses prevention because treatment options can become very limited once disease is chronic. (07:27 – 13:04)

Key nutrients involved in inflammation. From there, Dr. Rico describes how omega-6 and omega-3 fatty acids help start and resolve inflammatory responses. He also explains that niacin (vitamin B3) supports the systems that defend against reactive oxygen species. In addition, he covers minerals and vitamin D3. He suggests that requirements built for maximum productivity may not fully cover immune protection during a challenge. (13:05 – 18:09)

The high-performance athlete analogy. Similarly, Dr. Rico compares high-producing cows to elite athletes: high output doesn't have to mean sickness when the right building blocks are supplied. He points to studies presented at the conference that saw improved immune responses when certain nutrients were supplied at three to four times the recommendation. In those studies, cows under challenge had less dramatic rectal temperatures and toned-down inflammatory markers. Importantly, he frames this as a question about supplementation during stress, not proof that cows are generally underfed. (18:10 – 21:02)

The open question of timing. Even so, timing is still uncertain. Research doesn't yet define exactly when supplementation should start ahead of heat stress. B-complex vitamins are metabolized quickly, for example, while vitamin D3 builds up differently in the body. As for omega-3s, cows don't yet have an established requirement. On top of that, rumen biohydrogenation and the very low conversion of alpha-linolenic acid to DHA and EPA create further bottlenecks. (21:03 – 24:48)

Management first: vaccination, cow comfort and stress. The conversation then turns to management. Dr. Fox advises against vaccinating during stress or when nutrition is inadequate. He also describes changing vaccine timing based partly on cowside sensor data. Together, he and Dr. Rico stress getting the basics right before fine-tuning supplementation: feed intake, lying time, bunk space, stocking density, feeding management and social stress. (24:49 – 30:30)

Transition cows and overconditioning. Around transition, Dr. Fox prefers to minimize disruption for about three weeks before and three weeks after calving. During that window, he prioritizes lying time, rumination, feed access and intake. The panel also looks at overconditioning and chronic low-grade inflammation. Dr. Fox argues that prevention has to start in late lactation, because overweight cows may already eat less before calving and regain their appetite more slowly afterward. (30:31 – 38:20)

Putting prevention into practice. Still, prevention can be hard to carry out with one-group TMR systems. Dr. Fox talks about separating first-lactation animals and adjusting diets for mature cows that are gaining too much weight. He notes, however, that everyday realities like pens, gates and people can undermine precise grouping. As a result, the speakers come back to forage quality, consistent husbandry and doing the basics well. (38:21 – 44:37)

Emerging strategies and final takeaways. Finally, the panel considers botanicals, polyphenols and other nutraceutical approaches for supporting immune response. Dr. Fox proposes a nutritional "pre-adjuvant" before planned vaccinations. Meanwhile, Dr. Rico notes that more research is needed, since nutrient requirements have traditionally focused on production rather than on preparing cows for stress. The closing takeaways center on management, cowside monitoring, earlier detection of uncontrolled inflammation in dairy cows and continued research into nutritional support for immune function. (44:38 – End)

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Frequently Asked Questions

What is uncontrolled inflammation in dairy cows? Inflammation is a normal, protective immune response, and cows need it for events like calving. It becomes uncontrolled when it isn't contained in extent or duration, or when it doesn't resolve properly. When that happens, it can contribute to health and performance challenges.

How can nutritional management support the immune response? The panel discusses nutrients such as omega-3 and omega-6 fatty acids, niacin (vitamin B3), minerals and vitamin D3. These nutrients play roles in starting and resolving inflammation and in antioxidant defense. Research is still exploring whether supplying more of them during stress can help.

Why does the transition period matter for inflammation? The weeks around calving bring major physiological change. Because of this, the speakers prioritize feed intake, lying time, rumination and limiting disruption. They also point to body condition management in late lactation as a key prevention step.

Does vaccination timing affect immune response? According to Dr. Fox, vaccinating during stress or when nutrition is inadequate may be less effective. He describes using cowside sensor data to help guide vaccine timing.

What is the most important takeaway from this episode? Get the basics right first: management, cow comfort, forage quality and monitoring. From there, research continues to look at how targeted nutrition can support immune function during stress.

 

Introductions and Symposium Previews

Dr. Andrew Lapierre shares the nearly 50-year history of CNCPS, and Dr. Jonas de Souza previews his work on fatty acid modeling. Dr. Veridiana Daley reviews milk protein modeling, amino acid nutrition and new technologies that could sharpen decision-making. (00:00 – 10:45)

Models in the Field

The consulting nutritionists explain how they use models' day to day. They discuss how ration software has evolved and why model outputs still need practical farm management and observation behind them. (10:46 – 15:12)

NASEM vs. CNCPS

The panel compares empirical and mechanistic models. Models are the best interpretation of available data, not perfect pictures of biology. That's why it's critical to understand each model's assumptions before acting on its recommendations. (15:13 – 19:25)

Protein and Rumen Degradable Protein Predictions

NASEM and CNCPS often reach different answers because they rely on different assumptions, microbial compositions and prediction methods. Neither is perfect, but both are useful for evaluating amino acid supply and nutrient responses. (19:26 – 24:08)

Modeling the Modern Dairy Cow

Genetic progress has raised production potential, yet many post-absorptive efficiency assumptions still come from older datasets. The panel names nutrient use efficiency and variable animal responses as key areas for future research. (24:09 – 29:46)

Making Practical Ration Changes

Nutritionists use models to guide gradual ration changes within real-world constraints. They also point out that management decisions can affect performance as much as the diet itself. (29:47 – 33:32)

Adding Sensor Data to Models

Rumination, rumen health and other precision dairy sensor data could improve intake predictions, flag health events and support nutritional decisions. (33:33 – 37:43)

Dry Matter Intake and Forage Quality

The panel looks at dry matter intake optimization and forage quality challenges. They also ask whether maximizing intake is always the most profitable strategy. (37:44 – 43:29)

Improving Feed Libraries and Response Models

The group sees room to expand response modeling and improve feed libraries. They also want to better characterize ingredients and add amino acid and fatty acid data, all while validating models against research and field datasets. (43:30 – 58:41)

The Future of Nutritional Modeling

Looking ahead, the panel discusses better fatty acid and amino acid prediction systems, sensor integration, artificial intelligence and stochastic modeling. They also call for stronger collaboration between researchers and field nutritionists, with better data and ongoing validation driving progress. (58:42 – End)

Conclusion

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Host Scott Sorrell is joined by Dr. Billy Brown (Kansas State University) and Carson Corwin (Kansas State University). The episode centers on Carson Corwin's presentation, "Effect of prenatal rumen-protected choline on dam feeding behavior and offspring mammary development."

Carson Corwin outlines the study design, which evaluated multiparous cows fed a rumen-protected choline supplement during the 21-day prepartum period. Individualized feeding bunks equipped with RFID technology were used to measure intake and feeding behavior, including meal timing, meal intervals, meal size, and number of meals. The team also followed heifer calves and collected mammary ultrasound images on days 1, 42, and 84. (03:15 – 05:43)

Discussing the results, Carson highlights what he describes as the most exciting finding: increased mammary parenchyma area in calves born to supplemented dams. The researchers also observed a tendency for a greater parenchyma-to-fat-pad ratio, which they describe as an indicator of greater mammary system development potential. Dr. Brown explains that the effect was observed across the evaluation period rather than at a single time point and notes an approximately 10% difference in the measured area. (05:44 – 07:49)

Dr. Brown places the findings into the context of earlier research that reported benefits in calf growth, immune responses, and longer-term development. He explains that previous studies and observations have suggested potential downstream production advantages, although some of those observations remain unpublished. The speakers emphasize that the current work is an early step toward understanding possible biological mechanisms and that additional follow-up is needed to determine how these developmental differences may relate to later-life performance. (07:50 – 08:59)

When discussing why prenatal choline exposure might influence calf development, Dr. Brown notes that the mechanism remains a "black box." He says the team's best speculation is that epigenetic factors may be involved, but stresses that researchers have not yet identified a definitive explanation. The conversation also turns to future work, including continued monitoring of the calves and plans to evaluate metabolic factors that could provide further insight into observed responses. (09:00 – 09:41)

Looking ahead, Carson shares plans for a new project evaluating a yeast supplement fed to prepartum cows beginning earlier in the dry period, with a focus on calf immune response and colostrum quality. The episode closes with reflections on future career goals and the researchers' enthusiasm for continuing to investigate how prenatal nutritional interventions may influence calf development. (09:42 – End)

Throughout the episode, the panel reinforces a central message: prenatal nutritional strategies may have effects that extend beyond the dam, but further research is needed to understand the biological mechanisms and long-term implications of those responses.

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The episode begins with introductions from Dr. Addison Carroll and Dr. Kelly Mitchell, who share their educational backgrounds, research experience, and current roles at Washington State University and Elanco Animal Health. They also preview the Tri-State Dairy Nutrition Conference session featuring presentations from Dr. Carroll, Dr. Edward Rico, and Dr. Kelly Nichols. Dr. Carroll's presentation, Nutrient Variation in Feed Delivery and the Impacts on Lactating Dairy Cows, provides the foundation for the conversation, examining how nutrient deviation can influence dairy cow performance and why understanding variation matters for effective feeding management. (00:00 – 03:26)

Nutrient variability can begin long before a dairy ration reaches the cow. Dr. Carroll explains that inconsistencies can originate from feed composition, ration formulation, ingredient loading, feed mixing, and cow behavior. Identifying where variation enters the feeding process, along with its potential economic consequences, can help dairy producers uncover opportunities to improve feed consistency and overall herd management. (03:27 – 05:20)

Breaking the dairy feeding process into four major areas, Dr. Carroll highlights variation associated with ration formulation, feed loading, feed mixing, and animal consumption. Human involvement in loading and mixing can be a significant source of inconsistency, while Dr. Mitchell notes that small variations at individual stages can compound throughout the feeding process. Understanding these sources provides a clearer picture of how the ration formulated by the nutritionist may differ from what ultimately reaches the cow. (05:21 – 08:26)

Drawing on research involving eight dairies ranging from 3,000 to 30,000 head, Dr. Carroll explains that nutrients were overfed 92% of the time, averaging approximately 25 of 28 days per month. However, the magnitude of nutrient deviation varied considerably among farms. These findings reinforce the importance of measuring and evaluating feed and nutrient variation at the individual dairy level rather than assuming every operation experiences the same degree of inconsistency. (08:27 – 10:58)

The conversation then examines the relationship between nutrient variation and dairy cow performance. The research linked greater starch deviation with lower dry matter intake but increased milk yield, while crude protein deviation was associated with increased feed intake. Greater NDF deviation was associated with reduced milk yield, and fat deviation was linked with improved pregnancy rate. Dr. Carroll notes that the relationship between crude protein deviation and reproductive performance deserves additional research. (10:59 – 13:19)

So, how can dairy farms better monitor feeding consistency? Dr. Carroll recommends using feed weights and loading records to establish benchmarks, with variation below 2% as the goal. Regularly reviewing feeding data and monitoring trends can help producers and nutritionists better understand nutrient deviation and identify where improvements may support more consistent dairy cow performance. (13:20 – 15:23)

Importantly, the discussion challenges the idea that all nutrient variation is necessarily negative. Dr. Carroll points to research showing that increases in dietary starch may result in short-term production responses. However, she cautions that the longer-term effects remain less clear, emphasizing the need to consider both immediate and long-term cow responses before adjusting dairy rations. (15:24 – 16:33)

Technology may also play a role in improving dairy feed consistency and precision feeding. Dr. Carroll discusses research evaluating a Vector feeding system, which showed modest improvements in variation for dry matter and ADF. The findings suggest that greater automation could help reduce some sources of feed delivery variation and support more precise nutrient management on dairy farms. (16:34 – 20:55)

Beyond technology, many opportunities for improving dairy feeding management may already exist in the data farms collect every day. Dr. Carroll encourages producers to review feed records, prepare for weather-related changes in dry matter intake, maintain consistent feed availability, and prioritize employee training. Analyzing existing feeding data can help dairy teams identify patterns and make more informed decisions about ration delivery and management. (20:56 – 23:42)

To close the conversation, Dr. Carroll returns to a central theme: nutrient variation does not have to be viewed solely as a problem. While consistency remains an important goal in dairy nutrition, nutrient deviation can also provide an opportunity for producers and nutritionists to examine cow responses, reassess feeding strategies, and better understand what the herd is telling them. Monitoring variation alongside production and reproductive data can provide valuable insight into opportunities for more precise dairy nutrition and feeding management. (23:43 – End)

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The panel features the speakers behind the symposium "Concepts and Strategies to Improve Physiological Resilience to Heat Stress in Dairy Cows": Dr. Yun Jiang (University of Wisconsin-Madison), Dr. Jimena Laporta (University of Wisconsin-Madison), Dr. Vincenzo Lopreiato (University of Messina), and Dr. Maya Zachut (Volcani Institute).

The episode begins with introductions. Dr. Jiang describes her research on stress mitigation and dairy nutrition sustainability, and Dr. Laporta shares her path from the University of Florida to UW. Dr. Lopreiato, based in Sicily, notes he has worked on heat stress for three years. (00:00 – 03:48)

The discussion turns to heat stress as a global issue. Dr. Zachut explains that cows in Israel are now considered heat stressed eight months a year, and that the topic has become relevant even in northern regions. She stresses that even the most advanced cooling systems cannot fully alleviate heat stress, which is why the symposium brings physiology and nutrition together. (03:49 – 09:19)

Dr. Jiang then shares her work on why some cows are naturally more resilient, showing smaller milk drops and less rise in body temperature. Resilient cows produced less methane and had lower inflammation, and she suspects differences in energy metabolism. With 64 cows, she notes the study was too small for genetic analysis. (09:20 – 11:58)

Attention then shifts to the dry cow and the "transition calf." Dr. Laporta explains that heat stress in the first 60 to 90 days of life affects the mammary gland, ovary, thymus, and spleen. Cooling pre-weaned calves improved survival and slightly increased milk production later as cows, an opportunity she calls practical for producers facing replacement shortages. (11:59 – 19:37)

Dr. Zachut next presents a 2x2 study comparing three versus six cooling sessions per day in mid-lactation cows, with or without beta-caryophyllene, a dietary cannabinoid. More cooling improved welfare, behavior, and milk production, but surprisingly had little effect on immune function after an intramammary LPS challenge. The best cooling plus the supplement showed synergistic effects. (19:38 – 26:10)

Dr. Lopreiato then discusses methionine and plant polyphenols, which both activate antioxidant defenses. He notes that even with efficient cooling, milk losses can reach 15%, and he suggests oxidative stress may be a key driver of heat stress damage. (26:11 – 32:18)

Particular emphasis is placed on fine-tuning, not suppressing, the immune response. Dr. Zachut calls cooling by far the strongest tool, but cows cooled three times daily with the supplement had resting times similar to cows cooled six times. The panel also discusses capsaicin-containing extracts, which may increase sweating, while Dr. Lopreiato highlights the importance of rumen protection. (32:19 – 38:47)

The panel also explores immune function in calves. Dr. Laporta explains that heat stress activates the calf's immune system but makes it less effective, with lower neutrophil function and more illness. Dr. Zachut sees young calves as an opportunity to feed polyphenols before the rumen is fully functional. (38:48 – 43:53)

The conversation concludes with key takeaways. Dr. Zachut notes that even the best-cooled farms still see losses in fertility and immune function, while Dr. Jiang asks whether heat-stressed cows have different nutrient requirements. Dr. Laporta emphasizes there is no one solution and that early life matters for building cows resilient to climate change. (43:54 – End)

Throughout the episode, the panel reinforces a central message: cooling remains essential, but it is not enough on its own, and pairing good management with targeted nutrition across every life stage offers the greatest opportunity.

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The episode opens with introductions. Dr. Santos, who has been at the University of Florida for almost 20 years, explains that Giovanna's undergraduate mentor at the University of São Paulo was his friend from grad school at the University of Arizona. She came to Florida with high recommendations after an externship at the University of Georgia. (00:00 – 03:06)

The discussion then shifts to Giovanna's study design. The data set included over 4,000 animals across 11 experiments and 38 treatments. About 21 phenotypic factors, including calving season, parity, dry period length, calf birth body weight, cow body weight, retained placenta and metritis, were first tested in univariable models. Factors with P ≤ 0.20 moved forward, and those with P ≤ 0.10 were kept in the final models for colostrum yield, fat and IgG. (03:07 – 05:01)

Giovanna then shares the colostrum yield results. Cows produced more colostrum in fall and summer, multiparous cows produced more, and a longer dry period was positively associated with yield. Surprisingly, dry matter, metabolizable protein and net energy intake had no significant association with colostrum yield, and the slope was actually negative. Cows that produced more colostrum also performed better in the first 10 weeks of the next lactation. (05:02 – 06:52)

A key theme of the episode is questioning the common advice to feed more protein before calving when colostrum is poor. Dr. Santos notes that cows eating 800 g of metabolizable protein showed no difference in colostrum yield compared with cows eating 1,400 g. He calls the strong genetic component, with moderate to high heritability, the nicest finding. It suggests cows could potentially be selected for better colostrum yield and composition, possibly as a trait separate from milk yield. (06:53 – 10:11)

The conversation also covers the biology behind colostrum IgG. It's still unknown whether colostrum IgG comes only from maternal blood or also from plasma cells in the mammary gland. Giovanna hopes to use RNA sequencing of the placenta to see whether a missing Fc receptor explains why IgG doesn't cross it. She also plans nutritional experiments to see whether specific nutrients change colostrum IgG. (10:12 – 13:01)

Next, Giovanna shares her plans to pursue a PhD and likely work in industry in the U.S. Dr. Santos points out research gaps, including limited data on immunoglobulin transporters in the ruminant placenta and how colostrum is made in ruminants. Much of that data currently comes from laboratory animals. (13:02 – End)

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Host Scott Sorrell is joined by co-host Dr. Laura Nihus (Balchem), Dr. Bill Weiss, and Steve Massie (Renaissance Nutrition) for a wide-ranging discussion on heat stress, leaky gut biology, transition cow management, inflammation, precision technologies, and the future of dairy cow health monitoring.

The conversation opens with introductions and backgrounds from the panel, highlighting decades of experience in dairy nutrition and physiology before transitioning into Dr. Baumgard’s research focus on stress biology across multiple species. (00:00 – 05:59)

Dr. Baumgard explains how his work evolved from studying heat stress in dairy cows to investigating broader mechanisms of stress physiology. Drawing from military and human medical research, he describes how heat stress can compromise gastrointestinal barrier function and how similar biological responses occur across species. (06:00 – 10:19)

The discussion explores the distinction between short-duration heat exposure used therapeutically, such as sauna treatments, and prolonged heat stress that negatively affects animal health and performance. The panel reviews how different stressors can influence metabolism, gut function, and animal productivity. (10:20 – 12:08)

Attention then shifts to the biological relationship between psychological stress, gut health, and immune activation. Dr. Baumgard describes evolutionary explanations for stress responses, including reduced feed intake, vomiting, diarrhea, and shifts in gastrointestinal function as defense mechanisms against pathogens. (12:09 – 15:52)

The panel examines how stress can alter gut microbial populations, reduce mucin production, increase gut permeability, and potentially promote pathogen growth and shedding. These changes help explain why stress frequently precedes disease challenges in dairy cattle and other species. (15:53 – 18:03)

A major topic throughout the discussion is the distinction between sterile inflammation and pathogenic inflammation. Sterile inflammation is a normal and necessary process associated with events such as calving and tissue remodeling, while pathogenic inflammation arises from infections or disease challenges. The panel discusses why differentiating between these two forms of inflammation is critical for developing effective prevention and treatment strategies. (18:04 – 24:37)

The conversation also touches on unexpected findings involving respiratory disease and lung pathology in transition cows. Dr. Baumgard shares observations suggesting that undetected respiratory issues may contribute to health problems more often than previously recognized. (21:03 – 23:21)

The panel then explores the future of precision dairy technologies. Feed intake monitoring systems, rumen boluses, activity collars, milk production records, and emerging predictive technologies may help identify health challenges days before clinical signs become obvious. The group discusses how these tools could transform transition cow management and disease detection. (24:38 – 29:43)

Individual variation among cows becomes another central theme. The speakers discuss why some animals appear more resilient to stress than others, even when exposed to identical environments and management conditions. They consider possible roles for personality traits, behavior, physiology, and individual adaptability. (29:44 – 32:40)

Management practices remain at the core of the conversation. The panel highlights transition cow overcrowding, facility limitations, feeding consistency, cow comfort, and overall farm environment as major contributors to stress and health outcomes. (32:41 – 35:41)

Additional discussion focuses on repeated versus stacked stressors, anti-inflammatory interventions, the role of inflammation in normal biology, and the challenge of balancing beneficial and excessive inflammatory responses. (35:42 – 40:35)

The group also reviews emerging industry tools such as the Fresh Cow Index (FCI) and discusses how milk production may serve as one of the most practical biomarkers of health available to dairy producers today. (40:36 – 43:33)

Throughout the episode, the panel emphasizes a central message: many of the biggest opportunities for improving cow health, resilience, and performance are rooted in management rather than nutrition alone. Reducing avoidable stressors, improving transition cow environments, and leveraging new technologies may ultimately provide the greatest gains in animal health and productivity.

Join nutritionists, researchers, veterinarians, and producers from around the world as they explore the latest science shaping the future of animal agriculture.

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The conversation begins with introductions and an overview of Dr. Wilkens' research examining vitamin D biology across ruminants and other livestock species. It is explained that vitamin D should not be viewed solely as a vitamin but rather as the precursor to a highly regulated steroid hormone system with complex feedback mechanisms that influence numerous physiological processes throughout the body. The panel discusses how activation and regulation of vitamin D metabolism affects livestock health and why a deeper understanding of these pathways continues to be important for both researchers and nutritionists (00:00 – 06:59).

Building on that foundation, the discussion explores emerging areas of vitamin D research beyond its traditional role in preventing rickets and supporting skeletal development. Evidence suggesting vitamin D may influence muscle function, recovery, immune responses, and other physiological systems is reviewed. However, the panel also emphasizes that caution should be exercised when interpreting observational studies, since associations do not necessarily establish causation. Consequently, additional controlled research is believed to be necessary before broader conclusions can be drawn (07:00 – 10:33).

Attention then turns to one of the most frequently debated questions in mineral nutrition: what constitutes an optimal vitamin D status in modern dairy cattle. Plasma 25-hydroxyvitamin D concentrations are discussed as a common biomarker, yet challenges remain when attempting to define ideal target values. Furthermore, differences observed between pasture-raised and indoor-housed animals are examined, illustrating the complexity of developing universal recommendations. As dairy production systems continue to evolve, uncertainty remains regarding the most appropriate vitamin D supplementation strategies for high-producing livestock (10:34 – 16:47).

The relationship between vitamin D, calcium, phosphorus, and vitamin K is subsequently explored. Questions surrounding vitamin K2 supplementation, calcium transport mechanisms, and mineral metabolism are discussed in detail. In addition, species-specific differences are highlighted as an important factor that complicates the development of broad nutritional recommendations across animal populations (16:48 – 18:38).

A major focus of the episode centers on phosphorus management and transition cow health. Dr. Wilkens and the panel discuss phosphorus binders and their potential role in hypocalcemia prevention by influencing calcium homeostasis. The biological mechanisms linking phosphorus restriction and calcium metabolism are examined, while practical questions regarding implementation and effectiveness are also considered. As a result, listeners gain insight into how phosphorus-binding strategies may complement established approaches used to reduce milk fever risk in dairy herds (18:39 – 21:24).

The conversation then shifts toward vitamin D's role in immune function. Research examining the local production of active vitamin D metabolites within immune cells is reviewed, along with evidence suggesting vitamin D status may affect immune responses under specific challenge conditions. While promising findings have been reported, the panel notes that additional work remains necessary to fully understand these relationships and their practical applications in livestock production systems ((21:25 – 23:10).

Vitamin D nutrition in calves and young animals is also discussed. Natural vitamin D concentrations found in colostrum and milk are reviewed alongside supplementation strategies commonly used in milk replacers. However, it is noted that much of the available research focuses primarily on preventing classical deficiency diseases, while comparatively little information exists regarding optimal vitamin D levels for growth, immunity, and overall performance in young animals. Consequently, significant opportunities for future research continue to exist in this area (23:11 – 27:16).

The episode also addresses vitamin D toxicity and excessive supplementation. Toxicity thresholds, elevated circulating 25-hydroxyvitamin D concentrations, and clinical observations from cattle and camelid species are examined. Furthermore, the panel discusses how different vitamin D metabolites can contribute to both intended physiological responses and unintended consequences when supplementation exceeds biological requirements (27:17 – 35:24).

A detailed conversation follows regarding the practical implementation of phosphorus binders in transition cow programs. Drawing from commercial field experiences, Dr. Schwab shares insights regarding dosage recommendations, monitoring strategies, lessons learned, and the potential risks associated with excessive phosphorus restriction. The panel also discusses how phosphorus binders are currently being utilized in commercial settings and where additional research is still needed to better define best practices (35:25 – 46:25).

The discussion then broadens beyond dairy cattle to examine phosphorus metabolism across species. Emerging concerns related to phosphorus consumption, kidney health, feline nutrition, and species-specific mechanisms of phosphorus absorption and regulation are explored. These comparisons provide valuable perspective on how findings from companion animal and human nutrition research may help guide future investigations in livestock species (46:26 – 50:53).

The episode concludes with reflections from each panelist on the future of vitamin D and mineral nutrition research. The complexity of vitamin D biology is emphasized throughout the discussion, while the need for additional dose-response studies is repeatedly highlighted. Similarly, the value of integrating field observations with mechanistic science is reinforced. Ultimately, continued collaboration among academia, industry, nutritionists, veterinarians, and producers is viewed as essential for advancing nutritional understanding and improving animal health outcomes (50:54 – 56:05).

Continue the Conversation at the Real Science Exchange

As new research continues to emerge in dairy nutrition and transition cow management, the Real Science Exchange podcast remains committed to bringing science-based discussions directly to industry professionals. If this episode was found valuable, it is encouraged to be shared with colleagues, nutritionists, veterinarians, researchers, and producers throughout the dairy industry.

Please subscribe and share with your industry friends. This helps increase awareness of topics like the impact of excess liver copper concentrations. Invite more people to join us at the Real Science Exchange virtual pub table. Please be sure to register for our upcoming Real Science Lecture Series.

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Introduction

The episode opens with introductions of Dr. Jonas de Souza, Steve Martin, and Dr. Ben Wenner, who discuss their backgrounds and experiences in dairy nutrition. The panel outlines the key topics shaping modern dairy nutrition, including fresh cow management, nutrient utilization, amino acid balancing, and the industry's growing adoption of response-based nutrition models designed to improve biological and economic outcomes. (00:00 – 03:26)

Fresh Cow Management in the Real World

Drawing on both research and field experience, the panel discusses transition cow management, fresh pen logistics, cow flow, and the operational challenges producers face when trying to maintain intake and health during early lactation. The speakers emphasize that successful fresh cow programs depend on both sound nutrition and consistent management practices. (09:06 – 18:56)

Why Academic Dairy Science Fails in Real-World Operations

One of the most engaging conversations centers on the gap between controlled university research and commercial dairy production. The panel explains how labor, facilities, stocking density, cow comfort, and day-to-day management practices often influence outcomes as much as nutrition itself, reinforcing the need to translate research into practical, farm-ready recommendations. (09:06 – 16:06)

Regional Differences in Dairy Management

The discussion explores how climate, labor availability, facility design, and production systems influence fresh cow performance across different regions. The speakers stress the importance of tailoring nutritional recommendations to each dairy rather than applying a one-size-fits-all approach. (18:56 – 24:06)

Why Feeding Methionine to Fresh Dairy Cows Is So Complicated

Methionine is one of the most studied amino acids in dairy nutrition, but applying recommendations in fresh cows remains challenging. The panel examines variable dry matter intake, energy balance, and the metabolic demands of early lactation that make amino acid balancing so complex. (16:11 – 24:04)

Energy Supply, Fermentable Starch, and Dietary Fat

Much of the discussion focuses on how energy drives production response. The panel discusses the relationship between fermentable starch, propionate production, nutrient partitioning, and milk production while examining how dietary fat and fatty acid profiles influence feed efficiency and performance. (24:06 – 31:39)

Should You Feed Fat and Fatty Acids to Fresh Cows?

The speakers evaluate the benefits and limitations of supplementing fat during the transition period, discussing how different fatty acid sources can impact energy balance, milk production, and fresh cow performance. (28:17 – 33:59)

Amino Acids for Dairy Cows: Lysine, Methionine, or Histidine?

As amino acid nutrition continues to evolve, the panel explores emerging research on amino acid balancing and discusses the roles of lysine, methionine, and histidine in supporting performance. Dr. de Souza reviews amino acid response models and essential amino acid targets while the panel shares practical perspectives from commercial dairy operations. (35:19 – 43:46)

Response Curves, Digestibility, and Return on Investment

The conversation turns to nonlinear optimization, nutrient digestibility, response curves, and economic returns. The speakers explain how these tools can help nutritionists improve efficiency and profitability while making more informed feeding decisions. (42:07 – 55:14)

The Surprising Truth About Palmitic Acid and Fiber Digestion

The panel explores how fatty acid profiles influence rumen function, fiber digestion, nutrient utilization, and production responses in high-producing dairy cows. The discussion highlights the complexity of balancing energy and fiber utilization while maximizing milk production and feed efficiency. (49:13 – 56:23)

Final Insights and Future Directions

The discussion concludes with insights on body condition scoring, herd monitoring tools, tracer cows, protein sourcing, muscle mobilization, and the future of dairy nutrition. Dr. Jonas de Souza, Steve Martin, and Dr. Ben Wenner emphasize the importance of combining research findings with practical farm experience to maximize cow performance, feed efficiency, and profitability while continuing to refine amino acid and energy nutrition strategies for modern dairy herds. (56:23 – 1:10:04)

Conclusion

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Recorded live at the Tri-State Dairy Nutrition Conference, this episode of the Real Science Exchange podcast explores one of the biggest opportunities facing modern dairy producers: unlocking the full genetic potential of today's high-producing cows through nutrition.

The conversation opens with introductions and a discussion of each speaker's background in dairy nutrition, fatty acid research, and commercial consulting. Dr. Bales shares insights from her graduate research on oleic acid and high-oleic soybeans, while Nate Elzinga discusses lessons learned working directly with dairy operations across Michigan. Their combined perspectives set the stage for understanding how science and practical farm management intersect. (00:00 - 05:31)

As the discussion progresses, Dr. Lock explains a critical concept shaping the future of dairy nutrition: genetics establish the ceiling for milk fat production, but nutrition, management, and environment determine whether cows actually reach that ceiling. The panel reviews how genomic selection has dramatically accelerated gains in both milk fat and milk protein output, creating new opportunities for producers who can provide nutritional programs capable of supporting these genetically advanced animals. (05:32 - 08:31)

While new technologies continue to emerge, the speakers repeatedly emphasize that forage quality remains the foundation of milk fat production. Success starts with highly digestible fiber, proper hybrid selection, timely harvest, and preserving forage quality throughout storage and feeding. High-producing cows can only express their genetic potential when the nutritional base of the diet is optimized. The panel discusses how forage management decisions often have a greater impact on long-term performance than any single feed additive or nutritional intervention. (08:32 - 11:03)

The conversation naturally transitions into the role of fatty acid nutrition. Research continues to demonstrate that milk fat responses depend not simply on feeding more fat but on delivering the right fatty acid profile. The group discusses the growing use of palmitic acid, oleic acid, and high-oleic soybeans, highlighting how different fatty acid sources influence milk fat production and overall cow performance. (11:04 - 13:27)

Building on that discussion, Dr. Lock introduces a more advanced framework for evaluating milk fat synthesis. Rather than focusing solely on dietary fat inclusion, he explains the importance of understanding fatty acid requirements on a molar basis. This perspective draws attention to the crucial role of de novo fatty acid synthesis within the mammary gland and reinforces how rumen fiber digestion supplies acetate and butyrate, two key building blocks needed to support increasing milk fat output. The message is clear: healthy rumen function remains essential for maximizing milk components. (12:18 - 16:10)

From there, the discussion shifts to transition cow management and the lasting impact of nutritional interventions during early lactation. The panel reviews research demonstrating that nutrition strategies implemented during the first few weeks after calving can influence milk yield, energy-corrected milk production, body condition, and overall lactation performance long after the treatment period ends. The fresh cow period presents a unique opportunity to establish the trajectory for an entire lactation. (16:11 - 21:41)

Several studies discussed during the episode evaluate combinations of higher metabolizable protein diets, protected amino acids, palmitic acid supplementation, and high-oleic soybeans. Results suggest that strategically combining these nutritional tools during early lactation may create additive responses that improve performance well beyond the immediate treatment window. (19:24 - 23:33)

Despite the strong biological responses observed with many premium nutrition programs, implementation ultimately depends on economics. The speakers discuss how milk prices, feed costs, and return-on-investment considerations influence producer decision-making. Even when nutritional technologies deliver measurable improvements in milk fat production, adoption can be challenging during periods of reduced profitability. (23:34 - 24:29)

As the episode concludes, the panel looks toward emerging opportunities in dairy nutrition, including amino acid balancing beyond lysine and methionine, evolving nutrition models, nutrient interactions between amino acids and fatty acids, and future strategies for optimizing milk components. Continued innovation will be necessary as dairy genetics continue advancing at a remarkable pace. (24:30 - 33:35)

Throughout the discussion, one message remains consistent: maximizing milk fat production requires far more than adding supplemental fat to a ration. Success depends on integrating genetics, forage quality, rumen function, fatty acid nutrition, amino acid balancing, and transition cow management into a comprehensive feeding strategy. When these factors work together, dairy producers can better position their herds to capture the full value of today's remarkable genetic progress.

Join dairy nutritionists, researchers, veterinarians, and producers from around the world as they explore the latest science shaping the future of animal agriculture.

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The episode opens with a discussion of the Florida Ruminant Nutrition Conference, one of the dairy industry's leading educational events. Dr. Santos reflects on the conference's growth, its practical focus on dairy nutrition, and the diverse international audience of researchers, nutritionists, and industry professionals it attracts each year. The speakers also discuss the critical role industry partnerships play in advancing applied dairy nutrition research and delivering science-based solutions to producers. (00:00 – 03:30)

Sebastian Salvatierra shares his educational background and his journey into graduate research at the University of Florida. He describes how his passion for dairy nutrition and applied research led him to investigate the use of DDGS as an alternative protein source for lactating dairy cows under the mentorship of Dr. Santos. (03:31 – 06:27)

Why Evaluate DDGS as a Soybean Protein Replacement?

The conversation shifts to the scientific rationale behind the project. The researchers hypothesized that replacing soybean-derived protein with protein supplied by DDGS could maintain dairy cow productivity while potentially reducing methane emissions. The discussion explores how the unsaturated fatty acids found in DDGS may act as hydrogen sinks during rumen fermentation, helping reduce methane production without compromising animal performance. (06:28 – 07:56)

Study Design and Experimental Approach

Sebastian explains the research methodology used to evaluate DDGS inclusion rates in dairy cow diets. The trial included multiple dietary treatments along with extensive measurements of production performance, blood metabolites, rumen fermentation characteristics, nutrient digestibility, and methane emissions. Importantly, the study was designed to reflect practical commercial feeding situations rather than highly controlled laboratory conditions, increasing the relevance of the results to real-world dairy operations. (07:57 – 08:31)

Effects of DDGS on Milk Production and Performance

Results from the study indicated that increasing DDGS inclusion did not negatively affect dry matter intake. While milk production increased modestly as DDGS replaced soybean protein, reductions in milk fat and milk protein concentrations influenced energy-corrected milk production in some treatment groups. The panel discusses possible explanations, including effects on ruminal fiber digestion, fatty acid metabolism, and milk fat synthesis. (08:32 – 09:51)

Growing Importance of DDGS in Global Dairy Nutrition

Dr. Santos provides broader industry context, highlighting the growing availability of DDGS in both the United States and Brazil as ethanol production expands. As a major co-product of the ethanol industry, DDGS continues to gain attention as a cost-effective feed ingredient that can contribute valuable protein, energy, and digestible nutrients to dairy rations. (09:52 – 11:02)

DDGS and Methane Reduction Opportunities

A major focus of the research centers on the relationship between dietary fat, rumen fermentation, and methane emissions. Preliminary findings suggest that moderate inclusion levels of DDGS reduced methane production while maintaining overall animal performance. The researchers also discuss ongoing efforts to evaluate digestible energy, metabolizable energy, and overall production efficiency associated with these dietary substitutions. (11:03 – 13:48)

Amino Acid Balancing and Practical Diet Formulation

The panel explains how the experimental diets were formulated using rumen-protected amino acids, including lysine and methionine, to maintain amino acid supply despite changing protein sources. The discussion emphasizes the importance of formulating diets that mirror practical commercial conditions so researchers can generate results that nutritionists and producers can confidently apply on farm. (13:49 – 15:54)

Understanding Variability in DDGS Quality

Not all DDGS sources are created equal. The speakers discuss how nutrient composition, sulfur concentrations, fatty acid profiles, and protein characteristics can vary considerably depending on ethanol plant processes and grain sources. As a result, ingredient evaluation, laboratory analysis, and quality control remain essential when incorporating DDGS into dairy nutrition programs. (15:55 – 18:26)

Economic and Sustainability Benefits of Feeding DDGS

Beyond nutrition, the researchers discuss the broader sustainability implications of incorporating DDGS into dairy cow diets. By effectively utilizing a major co-product from ethanol production, dairy producers can support circular agriculture systems while potentially reducing feed costs. The panel notes that converting co-products into nutrient-dense foods such as milk represents an efficient use of agricultural resources and contributes to overall feed system sustainability. (18:27 – 22:46)

Digestibility and Protein Utilization Research

Additional research is underway to better understand how DDGS influences protein digestibility, amino acid availability, and nutrient utilization. Because DDGS undergoes heat processing during manufacturing, protein characteristics can differ from other protein sources, potentially affecting utilization efficiency and helping explain some of the production responses observed in this study. (22:47 – 24:01)

Future Research and Industry Collaboration

The episode concludes with Sebastian discussing his future academic goals, including plans to pursue a PhD at the University of Florida. Dr. Santos and Dr. Marinho also highlight the importance of continued collaboration between universities and industry partners to advance dairy nutrition science, improve sustainability, and support the development of practical feeding solutions for dairy producers worldwide. (24:02 – 32:32)

Conclusion

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The conversation begins with introductions from experts specializing in dairy genetics, reproductive management, transition cow health, and calf monitoring technologies, providing insight into how precision dairy tools are being applied across the dairy industry. 0:00-6:21 The panel then explores the evolution of computer vision and artificial intelligence, discussing how modern dairy technologies are moving beyond simple data collection to deliver actionable insights that help producers solve real-world challenges. They also examine technology adoption trends, workforce development, and the barriers farms continue to face, including connectivity and technical support. 9:32-24:08 A major focus of the discussion is precision health monitoring for transition cows and calves. The experts explain why the transition period remains one of the most critical opportunities for intervention and how emerging technologies can help identify animals needing attention while addressing the challenges of managing "yellow cows" that fall between healthy and sick. 24:08-36:11 Looking toward the future, the panel explores digital twin technology, genetic considerations, calf health monitoring, audio sensing, and innovative approaches such as Wi-Fi-based cattle monitoring systems. The discussion highlights how these emerging technologies may further advance precision dairy management in the coming years. 36:11-45:55 The episode concludes with a discussion on dairy welfare monitoring, AI model development, and reinforcement learning, emphasizing the importance of transforming large amounts of farm data into meaningful information that supports animal wellbeing and management decisions. 46:41-52:10

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Stress is often associated with obvious challenges such as heat or transportation, but Dr. Baumgard explains that many stressors trigger similar biological responses. Understanding these shared pathways provides important insight into how stress influences animal health, nutrient utilization, immune function, and ultimately dairy cow performance. (00:00 – 05:16) 

The panel examines common stressors encountered in dairy systems, including heat stress, weaning, overcrowding, feed interruptions, dehorning, environmental noise, facility design challenges, and routine management disruptions. The speakers emphasize that stress is not always obvious. In addition, they note that multiple seemingly minor challenges can collectively impact health, welfare, and productivity. (05:17 – 08:29) 

A major portion of the discussion focuses on what happens inside the animal during periods of stress. Dr. Baumgard explains how activation of the hypothalamic-pituitary-adrenal (HPA) axis triggers a cascade involving mast cell signaling, reduced mucus production, and increased intestinal permeability. These physiological changes can create conditions that favor pathogen growth. In addition, they can increase inflammation, and reduce productive efficiency. (08:30 – 11:12) 

The conversation then turns to gastrointestinal barrier dysfunction, often referred to as "leaky gut." The panel discusses the gut's role as a critical defense system and explains why maintaining intestinal integrity is essential for nutrient absorption, immune regulation, and overall animal health. When stress compromises this barrier, animals become more susceptible to inflammation and disease challenges. (11:13 – 13:26) 

While nutrition can play a supportive role, Dr. Baumgard argues that reducing stress through management practices often delivers the greatest return on investment. Preventing stress before it occurs is frequently more effective than attempting to correct physiological disruptions after they have already begun. (13:27 – 14:18) 

The speakers also explore the concept of adaptation and stacked stressors, particularly during the transition period. Transition cows frequently encounter multiple challenges simultaneously. Moreover, the cumulative effects of several stressors may overwhelm an animal's ability to adapt. This helps explain why health disorders and performance declines often emerge during critical production stages. (14:19 – 17:28)

Heat stress receives special attention as one of the most economically significant stressors affecting dairy cattle worldwide. Dr. Baumgard details how heat stress redistributes blood flow away from the gastrointestinal tract, leading to gut hypoxia and impaired intestinal function. The discussion also examines why cows naturally reduce feed intake during hot conditions. In addition, it explains why cooling and management interventions often outperform nutritional strategies alone. (17:29 – 27:04)

The panel then reviews nutritional approaches that may help support animals during periods of stress. While antioxidant responses have been inconsistent across research studies, Dr. Baumgard highlights evidence suggesting that highly bioavailable zinc sources can consistently support intestinal integrity. These zinc sources can also improve resilience during stressful events. (27:05 – 32:22)

Another key topic is immune activation and nutrient partitioning. The speakers explain that activated immune systems become major consumers of glucose and amino acids, diverting nutrients away from productive functions such as milk synthesis. This shift helps explain why production losses during stressful periods often exceed what would be expected from reduced feed intake alone. (32:23 – 37:13) 

The episode concludes with a discussion on inflammation, endotoxin handling, mineral metabolism, hypocalcemia, and future research priorities. The panel examines how inflammation influences calcium and trace mineral dynamics during the transition period. Furthermore, they discuss the ongoing challenge of identifying practical solutions to stress-induced gut barrier dysfunction. (37:14 – 45:38)

Understanding stress physiology requires looking beyond individual stress events and recognizing the interconnected biological systems that influence animal performance. Whether stress originates from environmental conditions, management practices, or physiological demands, many stressors converge on common pathways that affect gut health, immune function, nutrient utilization, and productivity. This episode provides valuable insight into the mechanisms behind those responses. Moreover, it highlights why effective stress management remains one of the most powerful tools for improving dairy cattle health and performance.

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The discussion begins with the origins of the research and the collaboration between Dr. Santos and Dr. Lima on large commercial dairies in California. They also share the challenges of conducting nutrition research under real-world dairy conditions. Additionally, they explain how these early studies became a cornerstone of transition cow nutrition research. Their experiences implementing treatments on commercial operations provided valuable insights. Ultimately, these insights would influence dairy management practices around the world. (00:00 – 05:22)

The conversation then shifts to the study objectives and hypotheses that guided the research. The researchers discuss how supplemental choline was expected to improve liver function by reducing triglyceride accumulation, enhancing fat export from the liver, and supporting energy metabolism during the transition period. The episode also reviews two complementary experiments. These experiments evaluated both prepartum-only and prepartum-plus-postpartum supplementation strategies. Thus, they helped establish a deeper understanding of choline's role in dairy cow health. (05:23 – 08:25)

The panel next explores the health and production outcomes observed in the research. Results included improvements in milk yield, energy-corrected milk production, and milk component yields, along with reductions in transition-related disorders such as clinical ketosis, mastitis, and retained fetal membranes. These findings were among the first to demonstrate a clear relationship between improved liver function and enhanced lactation performance. As a result, they helped reshape how the industry viewed transition cow nutrition. (08:26 – 17:38)

One of the most influential aspects of the study was the liver biopsy research discussed later in the episode. Dr. Lima explains how cows supplemented with rumen-protected choline exhibited lower liver triglyceride concentrations than unsupplemented cows. The researchers also found a strong relationship between plasma choline concentrations and improved liver health. Therefore, this provides some of the most direct evidence supporting the proposed mechanism behind rumen-protected choline supplementation. (17:39 – 22:26)

Beyond liver health, the conversation explores potential biological mechanisms that may explain reductions in mastitis and retained placentas among supplemented cows. The panel discusses how improved liver function may support immune competency, reduce inflammatory burden, and improve nutrient utilization during the transition period. These findings suggest that the benefits of choline supplementation extend beyond preventing fatty liver. Furthermore, they may contribute to broader improvements in overall cow health and resilience. (22:27 – 26:42)

The discussion then expands into feed efficiency, dry matter intake, nutrient digestibility, and emerging research hypotheses surrounding choline's impact on whole-animal metabolism. The researchers reflect on how the original study sparked decades of additional research investigating the role of choline in dairy cow productivity, reproduction, metabolic health, and long-term performance. They also discuss new areas of interest, including potential effects on lower-gut fermentation and nutrient utilization. (26:43 – 30:51)

The conversation then turns to health outcomes. The researchers review reductions in clinical ketosis, mastitis, retained placenta incidence, and overall disease burden observed among supplemented cows. Potential biological mechanisms are explored, including improved liver function, enhanced immune competence, reduced inflammation, and better metabolic adaptation to the transition period. (30:52 – 38:19)

As the episode concludes, Dr. Santos and Dr. Lima reflect on the lasting impact of the research and how one of the earliest commercial dairy studies evaluating rumen-protected choline helped establish the scientific foundation for what has become one of the most extensively researched nutritional interventions in transition cow management. Their conversation provides valuable historical perspective on the evolution of dairy nutrition science. It also highlights why rumen-protected choline continues to play an important role in supporting transition cow health and performance today. (38:20 – 48:29)

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Drawing on decades of research and practical field experience, the panel begins by examining large laboratory datasets that reveal substantial variation in trace mineral concentrations across forages and total mixed rations. These observations highlight the importance of understanding real-world variability rather than relying solely on average values when making nutritional decisions. (00:00–03:16)

The discussion quickly moves into one of dairy nutrition's most debated topics: the reliability of TMR testing. While many nutritionists use TMR analyses as a quality control measure, others remain skeptical due to the challenges associated with obtaining representative samples from inherently heterogeneous rations. The panel agrees that TMR testing can provide valuable information, but only when consistent sampling protocols and proper laboratory procedures are followed. (03:16–06:46)

Building on this theme, the group discusses mixer studies as a powerful quality control tool. By evaluating nutrient variation within a load and across multiple batches, producers and nutritionists can better assess feeding consistency, identify operational issues, and improve ration delivery accuracy. These studies often provide a more complete picture of feeding performance than a single feed sample alone. (06:46–12:12)

A significant portion of the conversation focuses on trace mineral supplementation practices. The panel notes that although average mineral concentrations may appear appropriate on paper, many diets still contain excessive levels of trace minerals. Overfeeding can increase costs, contribute to nutrient antagonisms, impair rumen function, and raise concerns about toxicity. The experts emphasize the importance of balancing supplementation programs based on actual dietary contributions rather than adding large safety margins. (12:13–16:46)

The discussion then shifts to the impact of soil contamination on forage analysis and nutrient interpretation. Soil contamination can dramatically influence ash concentrations and artificially inflate measured trace mineral levels, creating challenges for nutritionists attempting to accurately evaluate feed value. The panel highlights emerging approaches, including the use of carbon measurements as a more precise indicator of contamination, which may improve how forage quality is assessed in the future. (16:47–25:47)

Regional differences in feed composition also receive considerable attention. Factors such as irrigation practices, soil characteristics, and co-product feeding programs can contribute to elevated sulfur and trace mineral concentrations in certain areas, increasing the risk of mineral antagonisms and affecting nutrient availability. Understanding these local influences is essential for developing effective mineral nutrition programs that are tailored to specific production environments.

Looking ahead, the panel explores innovations that could transform feed evaluation and ration formulation. Topics include amino acid profiling, the industry's gradual move beyond crude protein as a primary nutritional metric, and the potential for artificial intelligence to improve predictions of forage quality and nutrient composition. These advances may provide nutritionists with more accurate tools for optimizing dairy cow performance and feed efficiency. (35:16–41:10)

The episode concludes with a practical takeaway for dairy producers, nutritionists, and consultants: laboratory analyses and advanced technologies are most valuable when paired with a thorough understanding of feed variability and strong on-farm quality control practices. Whether evaluating trace minerals, interpreting forage analyses, or implementing new technologies, success ultimately depends on consistently managing variation throughout the feeding system.

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Dr. Mike Van Amburgh begins by outlining how amino acid nutrition has historically been viewed almost exclusively through the lens of milk protein. He explains that emerging research clearly shows amino acids play far broader roles in the cow, influencing milk fat synthesis, energy metabolism, and overall efficiency. As genetic potential has increased, amino acids are now supporting many biological pathways beyond simple milk protein yield. (05:50) 

Dr. Van Amburgh explains that dairy systems across Europe and North America are under increasing pressure to reduce nitrogen losses. By formulating more precise diets that better match amino acid requirements, cows can excrete significantly less urinary nitrogen while maintaining—or even improving—milk production, creating both environmental and economic benefits. (09:30) 

The panel discusses the robustness of current CNCPS model libraries and explains why forage amino acid profiles tend to be relatively conserved. While management factors like heat damage or poor fermentation can alter availability, microbial protein ultimately supplies a large and consistent portion of metabolizable amino acids to the cow. (12:15) 

Dr. Van Amburgh emphasizes that microbial protein should supply roughly half of total amino acid needs, making rumen efficiency critical. However, as production levels rise, microbial protein alone is no longer sufficient creating a clear role for rumen‑protected amino acids to close growing nutritional gaps. (16:20) 

Dr. Usman Arshad then leads a deep discussion on choline and methionine in transition cows. He explains why these two nutrients are not interchangeable, despite both acting as methyl donors. Choline has a unique lipotropic role in supporting liver fat export and reducing fatty liver risk during early lactation, while methionine primarily supports milk production and protein synthesis. Research shows that choline supplementation during the transition period alone can generate lasting carryover improvements in milk yield later in lactation. (29:00) 

The panel addresses a common industry question: how much choline is enough? Dr. Arshad reviews decades of research, including meta‑analyses showing a largely linear response between choline ion intake and milk production. While 12–13 g/day of choline ion remains, the standard recommendation based on most available studies, data suggest additional benefits may exist at higher levels—even though more research is still needed. (34:00) 

Dr. Van Amburgh explains that recent infusion and feeding studies demonstrate much higher metabolizable protein requirements than traditionally assumed, driven in part by the important role of non‑essential amino acids. These nutrients support energy generation, glucose synthesis, and tissue metabolism during early lactation—contributing to substantial gains in energy‑corrected milk when requirements are met. (44:30) 

The panel also discusses whether amino acid balancing can help cows cope with heat stress. While amino acids do not eliminate heat stress, improving metabolic efficiency appears to reduce wasted heat production and support immune function and gut integrity, potentially helping cows better navigate stressful conditions. (54:45) 

The group shares real‑world examples showing that improving amino acid balance often increases milk components without increasing intake, frequently delivering returns of 2:1 or greater, depending on milk pricing and market structure. (58:00) 

Dr. Van Amburgh then offers candid insights into rumen‑protected amino acid bioavailability, explaining that products on the market are not created equal. Independent testing has shown efficiencies ranging from as low as ~10% to as high as ~80%. The panel stresses that transparent, published bioavailability data are essential for accurate formulation and for maintaining credibility across the industry. (01:01:30) 

Lastly, the panel examines modern high‑starch diets, monensin use, and intake regulation. Dr. Van Amburgh suggests many systems may now be producing excessive propionate, potentially limiting intake through chemical fill. He argues that rebalancing starch and NDF—rather than simply adding more concentrate—may unlock better efficiency and performance. (01:10:00) 

The episode concludes with final audience questions. (01:20:29) 

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The episode begins with an introduction to the panel and research objectives. This sets the stage for a deeper discussion on how elevated liver copper levels may influence immune resilience in crossbred calves. The panel examines why the impact of excess concentrations of liver copper is significant for animal health. (00:00 – 02:55)

Dr. Hansen then provides an overview of the featured Journal of Animal Science study, emphasizing its interdisciplinary approach and the motivation behind evaluating copper status in emerging beef-on-dairy production systems. She also references how excess copper concentrations in the liver can alter expected outcomes. (02:55 – 05:47)

As the discussion progresses, the panel highlights how copper accumulates throughout the production cycle, from late gestation through milk replacer feeding. This results in many calves entering the feedlot with elevated liver copper levels. The excess may influence health outcomes. Importantly, the impact of liver copper concentrations in excess is considered in feedlot transition and calf growth. (05:47 – 10:33)

A key theme throughout the episode is the concept of subclinical copper toxicity, where animals may experience negative physiological effects without obvious clinical signs. The panel explains how traditional definitions of copper toxicity may overlook subtle yet economically significant impacts on immune function and disease susceptibility, this is particularly important in relation to BRD. In the context of excess liver copper concentrations, even mild impact on metabolic processes is discussed. (10:33 – 12:28)

Dr. Hansen then walks through the experimental design, outlining how calves were assigned to high and adequate-copper groups. They were subjected to a controlled BRD challenge that incorporated stress, viral exposure, and bacterial infection. These steps better simulate real-world conditions. The impact of concentrations exceeding normal liver copper thresholds is addressed in their study design. (12:28 – 17:46)

The findings reveal that calves with elevated liver copper levels experienced more severe disease outcomes. This includes higher clinical scores, increased lung consolidation, and slower recovery. Therefore, excess copper in the liver clearly demonstrates a measurable impact on calf recovery and health status. (19:18 – 23:50)

The panel explores potential mechanisms behind these results, including increased oxidative stress, reduced antioxidant capacity, and disruptions to normal immune signaling pathways. Next, the discussion also examines how excess copper may interfere with nutritional immunity. This happens by altering the balance and movement of other essential trace minerals, such as zinc and iron, during infection. Ultimately, this compromises the animal’s ability to respond effectively to disease challenges. (27:17 – 29:10)

From a practical standpoint, the episode provides valuable guidance on managing copper supplementation in cattle diets. The panel emphasizes the importance of evaluating total mineral intake across life stages. They recommend carefully formulating diets to avoid over-supplementation. They discuss the challenges associated with reducing liver copper once it has accumulated and the time required to bring levels back into an optimal range. Most notably, managing the impact of excess concentrations in liver copper requires proactive nutrition strategies. (34:26 – 36:07)

The episode concludes with a discussion on diagnostic tools and future research needs, including the role of liver biopsies in accurately assessing copper status and the limitations of blood biomarkers. There is also a need for a deeper understanding of mineral dynamics during disease. The panel highlights the importance of industry education and awareness as this issue continues to gain attention. To summarize, the impact of excess liver copper concentrations is a subject demanding ongoing research and producer awareness. (43:12 – 47:15)

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Why the Transition Period Is a Critical Window for Dairy Cow Health (02:10 – 10:36)

The discussion begins by examining the transition period as one of the most challenging phases in a dairy cow’s lifecycle. Research suggests that 30–50% of disease events occur within the first three weeks after calving, making this a key window for understanding and supporting immune function.

Dr. Rostoll-Cangiano shares insights into the biological changes that occur during this time, emphasizing the importance of immune adaptation as cows move from late gestation into early lactation.

Immune Cell Dynamics and Metabolic Stress in Transition Cows (02:10 – 10:36)

Building on this foundation, Dr. Rostoll-Cangiano discusses emerging research on T-cells, dendritic cells, and the differences between systemic and intestinal immune responses. The panel explores how immune cells face substantial metabolic demands after calving, often becoming metabolically constrained as they attempt to support both immune defense and milk production.

This competition for energy and nutrients may leave cows more susceptible to disease challenges and environmental stressors during the transition period.

Dry Period Management and Prepartum Feed Intake (10:36 – 16:26)

The conversation then turns to management practices that can influence transition success before calving. The panel examines how changes in dry matter intake (DMI), bunk space availability, and social stress can significantly affect a cow’s metabolic health and immune resilience.

Maintaining consistent feed intake and minimizing unnecessary stressors during the dry period are highlighted as key strategies for supporting a smoother transition into lactation.

Genetics, Productivity, and Cow Resilience (17:52 – 24:44)

The group explores whether modern dairy genetics have altered the balance between productivity and resilience. While today’s dairy cows produce substantially more milk than previous generations, the panel discusses whether this increased productivity may come with narrower physiological margins under stress.

The discussion highlights the ongoing challenge of improving production while preserving the ability of cows to adapt to metabolic and environmental stressors.

Factors Affecting Colostrum Quality and Calf Immunity (28:17 – 35:18)

Attention then shifts to colostrum production and quality, with a focus on how maternal health before calving can influence calf outcomes. 

Topics include the effects of:

• Metabolic status during the transition period
• Somatic cell count at dry-off
• Prepartum inflammation
• Immunoglobulin G (IgG) concentration
• Passive transfer and calf health

The panel explains how these factors can influence both the quality of colostrum and the long-term health and performance of newborn calves.

Nutritional Interventions to Support Transition Cow Performance

The experts review research evaluating choline and chromium supplementation as potential tools for supporting transition cow health and improving colostrum production. While published responses have been variable, these nutritional strategies continue to receive attention for their potential role in enhancing metabolic function and immune responses around calving.

Precision Dairy Technologies for Managing At-Risk Cows (37:27 – 44:51)

The conversation expands into 
 activity monitors and rumination tracking systems. These tools allow producers to identify at-risk cows earlier, monitor behavioral changes, and make more informed management decisions at the individual cow level.

By detecting potential problems before clinical signs appear, precision technologies can help improve intervention timing and overall herd health outcomes.

Key Transition Cow Management Takeaways

The episode concludes with a reminder that, despite advances in dairy research and technology, strong management fundamentals remain the most effective way to support cow health and performance:

• Maximize dry matter intake
• Reduce stress and unnecessary regrouping
• Manage body condition score changes
• Prioritize cow comfort
• Provide adequate feeding and resting space

Ultimately, while the biology of transition cows is complex, the panel emphasizes that the greatest improvements in health, productivity, and resilience often come from consistently executing proven management practices.

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The episode opens with a discussion on the growing importance of milk components in today's dairy economy (00:00 – 03:52). As demand for cheese, yogurt, high-protein dairy products, and dairy nutritional ingredients continues to increase, producers are finding greater value in maximizing milk fat and protein production. Rather than focusing solely on milk volume, they prioritize these components. The panel explains how evolving market dynamics have shifted management priorities. In addition, these changes have created new opportunities for dairies that can consistently deliver higher component yields.

The conversation then examines the remarkable evolution of milk component production over the past decade (03:52 – 10:33). The producers reflect on how advances in genetics, breeding strategies, and management practices have transformed herd performance. What was once considered exceptional production has become increasingly achievable. Now, dairy operations combine superior genetics with better management and nutrition programs. The discussion demonstrates how continual improvement has redefined expectations across progressive dairy farms.

A significant portion of the conversation focuses on nutrition and rumen function as foundational drivers of component production. The panel discusses the importance of maximizing energy density, balancing amino acids, and maintaining exceptional forage quality to support today's genetically advanced dairy cows. To achieve higher milk component goals, producers focus on nutritional programs that support both peak production and long-term cow health.

Next, attention shifts to cow comfort and facility design (12:29 – 22:12), with the panel emphasizing that even the best genetics and nutrition programs can be limited if cows are exposed to environmental stress. The producers discuss the impact of ventilation systems, cooling technologies, airflow management, and barn design on overall herd performance. Modern approaches such as tunnel ventilation and enhanced cooling systems have significantly improved cow comfort. These innovations help minimize heat stress and maintain consistent milk component production throughout the year.

The discussion continues with transition cow management and the benefits of reducing culling rates (22:12 – 26:26). The panel explains how improvements in transition management, feeding consistency, and day-to-day operational execution have enabled cows to remain productive in the herd for longer periods. By supporting cows through critical transition periods, producers can improve lifetime productivity. This, in turn, creates greater opportunities to maximize component output.

Technology adoption and innovation are also explored, including lessons learned from robotics and automation (26:27 – 29:43). The speakers share real-world experiences, both successes and setbacks, emphasizing that not every technology investment automatically delivers value. The discussion reinforces the importance of carefully evaluating return on investment, labor impacts, operational compatibility, and long-term sustainability before implementing new systems at scale.

One of the strongest themes throughout the episode is consistency (29:44 – 37:22). Whether discussing forage quality, feeding accuracy, ration consistency, cow routines, or management practices, the panel repeatedly emphasizes that elite performance is built on stable, repeatable processes. Consistency reduces variability, improves rumen health, and allows cows to express their genetic potential more effectively. According to the producers, exceptional results are rarely achieved through dramatic changes. Instead, they are created through disciplined daily execution over time.

Finally, the episode concludes with practical advice for dairy producers aspiring to achieve elite milk component production (37:22 – 41:06). The panel emphasizes the importance of adopting a growth mindset, maintaining attention to detail, building strong systems, and committing to continuous improvement. While there is no single formula for success, the speakers agree that high-performing dairies share a common commitment to excellence. This commitment is present across every aspect of their operation.

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The episode opens with introductions and an overview of the discussion, establishing the critical role trace minerals play in modern beef production (00:00 – 01:35). The conversation frames mineral nutrition not simply as a requirement for preventing deficiencies, but as a strategic management tool that can influence animal performance, health, reproductive success, and profitability throughout the production cycle.

Early in the discussion, Dr. Hansen introduces her "Olympic podium" framework for evaluating mineral nutrition programs (01:35 – 06:28). She describes bronze-level nutrition as meeting basic NRC requirements, silver-level nutrition as incorporating regional considerations and mineral antagonists, and gold-level nutrition as fully optimized supplementation tailored to the unique challenges and goals of a specific production system. This framework highlights the difference between simply meeting minimum requirements and strategically maximizing animal performance through precision nutrition.

The conversation then examines how dramatic advances in genetics, nutrition, and management have transformed the beef industry (06:28 – 07:42). Today's cattle are capable of growth rates, feed efficiencies, and production outcomes that exceed historical standards, prompting questions about whether traditional mineral recommendations remain adequate for supporting the needs of modern animals. As performance expectations have evolved, mineral nutrition strategies may need to evolve as well.

One of the most important discussions in the episode focuses on the balance between zinc and copper supplementation (07:42 – 13:13). Dr. Hansen explains that while zinc frequently delivers benefits at higher inclusion levels due to its involvement in countless biological processes, copper requires a much more cautious approach. The panel discusses how copper availability is heavily influenced by antagonists and how both deficiency and excess can create significant challenges. Rather than relying solely on predetermined mineral ratios, producers are encouraged to evaluate their systems holistically and make decisions based on actual risk factors and mineral availability.

A major theme throughout the episode is the impact of mineral antagonists and water quality on trace mineral status (13:13 – 17:18). The discussion highlights sulfur, iron, and molybdenum as some of the most important antagonists affecting mineral absorption and utilization. Water quality often receives less attention than feed ingredients, yet seasonal changes, differences in water sources, and fluctuations in mineral content can substantially influence animal performance. Understanding these variables is essential for developing effective supplementation programs that account for real-world production conditions.

The conversation then shifts to reproductive performance and immune health, with particular emphasis on zinc's biological importance (17:18 – 22:14). Often referred to as the "spark of life," zinc plays critical roles in early embryo development, cellular function, tissue repair, and immune response. The panel explains why maintaining adequate zinc status can have far-reaching implications for fertility, calf viability, and overall herd productivity, making it one of the most influential trace minerals in beef cattle nutrition.

A particularly timely discussion centers on the growing population of dairy-beef cross calves entering beef production systems (22:14 – 27:57). Dr. Hansen explains that these animals may arrive with mineral profiles that differ substantially from traditional beef calves. While many native beef calves often enter feedlots with copper deficiencies, dairy-beef calves may possess excessively high liver copper concentrations due to different management and supplementation practices. These differences underscore the need for targeted mineral programs rather than blanket recommendations applied across all cattle populations.

Beyond these key topics, the panel shares practical management strategies for improving mineral nutrition in commercial beef operations. The discussion explores how mineral supplementation can be viewed as a form of risk mitigation, helping animals better withstand stressors such as transportation, weather fluctuations, health challenges, and inconsistent feed intake. The speakers also emphasize the importance of adjusting supplementation strategies based on antagonists and environmental conditions rather than relying exclusively on fixed formulations. Additional insights focus on improving consistency in cow-calf mineral delivery systems and developing nutrition programs that support long-term herd resilience.

The episode concludes with a reminder that modern beef production systems are increasingly diverse and complex. As genetics, management, and production goals continue to evolve, mineral nutrition programs must become more targeted and system-specific. Success depends on understanding the unique challenges within each operation and developing strategies that optimize animal health, reproductive performance, efficiency, and lifetime productivity.

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The episode opens with introductions to the panel and co-host Dr. Mariana Marenho, highlighting her background in ruminant nutrition and setting the stage for a discussion that bridges academic research with real-world application. (00:00 – 01:27) 

The conversation then introduces the featured Journal of Dairy Science review paper, focusing on the regulation of hepatic glucose production “carbon by carbon.” Dr. White shares how the paper originated from an invited symposium and the collaborative effort to connect detailed biochemical mechanisms with practical dairy nutrition strategies. (01:27 – 04:15) 

The discussion quickly centers on a foundational concept in ruminant biology: dairy cows must synthesize nearly all their glucose internally. Unlike monogastrics, cows rely on hepatic gluconeogenesis to generate the large amounts of glucose needed to support lactose production—and therefore milk yield—making this process essential for performance. (04:15 – 08:44) 

From there, the panel explores how glucose production directly drives milk synthesis, emphasizing that lactose production determines milk volume. This creates a continuous metabolic demand on the liver, requiring cows to sustain high rates of glucose production throughout lactation. (08:44 – 09:53) 

The discussion then shifts into the primary substrates for gluconeogenesis, including propionate, amino acids, lactate, and glycerol. The panel explains why propionate is the dominant precursor in fed cows and how efficient rumen fermentation is critical to supporting glucose supply. (09:53 – 11:13) 

The conversation also revisits the concept of bypass starch, challenging the idea that delivering glucose directly to the small intestine can offset hepatic glucose production. The panel explains how glucose sparing mechanisms in ruminants limit the effectiveness of this strategy, as absorbed glucose is often utilized by other tissues instead of supporting milk production. (11:13 – 13:17) 

Attention then turns to practical feeding strategies, particularly how to increase propionate supply through forage quality, rumen fermentation management, and dietary tools such as ionophores and targeted supplements. These approaches help ensure that cows have adequate precursors to meet their genetic potential for milk production. (13:17 – 14:29) 

The episode also dives deeper into nutrient partitioning and metabolic regulation, highlighting how the availability of precursors must align with gene expression and enzyme activity. The panel discusses how nutrients like choline can influence gluconeogenesis not just as substrates, but as regulators of metabolic pathways. (14:29 – 27:30) 

From a management perspective, the panel emphasizes foundational practices such as high-quality forages, consistent feed intake, and transition cow management. Maintaining rumen health and minimizing disruptions in feeding behavior are critical for supporting stable nutrient supply and efficient glucose production. (27:30 – 30:07)

The discussion also explores the impact of feeding behavior, competition, and daily nutrient flow, showing how disruptions in intake patterns can affect rumen fermentation dynamics and ultimately nutrient partitioning within the cow. (30:07 – 32:31) 

Finally, the episode examines the role of genetics and future research opportunities, noting that modern dairy cows already have increased gluconeogenic capacity due to selection for higher milk production. The remaining challenge lies in optimizing nutrition and management to fully support that genetic potential. (34:32 – 37:14) 

The episode concludes by emphasizing the importance of integrating fundamental biochemical research with practical feeding strategies, reinforcing that understanding metabolism at a deeper level can lead to more precise and effective nutrition programs on farm. 

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Lara Moody (iFeeder), Dr. Yuan-Tai Hung, and Leah Wilkinson (AFIA) join the Real Science Exchange podcast to explore the growing concern around vitamin and amino acid supply chain disruptions—and their potential impact on U.S. food security.

Recorded live at IPPE, this episode dives into how feed ingredient availability influences animal performance, producer profitability, and long-term resilience across the food system. The conversation opens with introductions and an overview of the iFeeder report, setting the stage for a data-driven discussion on supply chain stability and its importance to the animal feed and food industries (00:00–01:08).

The panel begins by outlining the mission of iFeeder and the origin of the resiliency challenge, explaining how the organization was tasked with delivering fact-based insights to quantify supply chain risks tied to vitamins and amino acids (01:08–03:19). The discussion then traces the report’s development back to COVID-19, when widespread disruptions exposed vulnerabilities in sourcing critical feed ingredients and highlighted the need for credible data to inform policymakers (03:19–04:15).

As the episode progresses, the panel walks through the data collection and analysis process, describing how global trade data is translated into meaningful, species-specific insights for producers and nutritionists (04:15–07:36). This foundation reinforces the importance of evidence-based decision-making across the industry.

The Role of Vitamins and Amino Acids in Animal Nutrition

Attention then shifts to the essential role of vitamin and amino acid supplementation in modern animal nutrition systems (07:36–09:18). While feed ingredients provide baseline nutrients, supplementation is required to support optimal production, maintain animal health, and ensure efficient growth across species.

These findings align with broader research showing that consistent access to these nutrients is critical for maintaining livestock productivity and food supply stability. [ifeeder.org]

The conversation further explores global production capacity, noting that many systems are currently operating below optimal utilization levels—raising concerns about long-term supply reliability and resilience (09:18–10:33).

Real-World Impacts of Supply Chain Disruptions

The panel then dives into the real-world consequences of nutrient shortages, using examples like lysine to demonstrate how disruptions can reduce growth rates, extend time to market, and significantly impact production efficiency (10:33–13:26).

These disruptions ripple throughout the value chain, influencing not only on-farm productivity but also economic outcomes and consumer-level impacts such as reduced food supply and higher prices (13:26–14:31).

Global Supply Dependency and Food Security Risks

The discussion also highlights global sourcing trends, particularly the increasing reliance on imports for vitamins and amino acids—often driven by cost advantages (14:31–16:50). This dependency introduces new vulnerabilities into the supply chain.

Industry research has shown that the U.S. feed sector relies heavily on a limited number of global suppliers, creating potential risks to animal production and broader food security if disruptions occur. [feedandadditive.com]

Policy, Innovation, and National Resilience

The conversation then transitions to policy and national security considerations, exploring how outsourcing production affects more than just agriculture (16:50–18:44). The panel discusses potential pathways forward, including the need to rebuild domestic capacity and enhance supply chain stability.

Ongoing legislative and policy efforts are also highlighted, including engagement with Congress and federal agencies to address supply chain risks through incentives, research investment, and public-private cooperation (18:44–20:51).

As the discussion continues, the panel emphasizes the importance of maintaining long-term momentum and ensuring sustained focus across political cycles, regardless of changing administrations (20:51–23:07).

Industry Resources and Call to Action

The episode also outlines available resources for industry stakeholders, including the full iFeeder report, summary versions, and species-specific subreports designed to make the findings more actionable (23:07–23:53).

The panel concludes with a call for continued industry support and investment in research to better quantify downstream impacts on food systems and strengthen overall resilience (23:53–26:44). The episode wraps with key takeaways emphasizing that supply chain risks are real, collaboration is essential, and long-term resilience is critical to sustaining animal agriculture and food security (26:44–28:49).

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The episode opens with a welcome to the podcast and introductions to the panelists. It highlights their diverse expertise in mineral metabolism, applied nutrition, and industry insights. (00:00 – 02:38)

The discussion begins with a deep dive into the mechanisms of mineral absorption, focusing on epithelial barriers and transporters. The panel discusses how minerals like magnesium are absorbed across the rumen wall. Moreover, they explore how antagonists interfere with absorption and introduce the concept of measuring bioavailability under field conditions. (04:35 – 10:13)

From there, the conversation shifts to practical dairy nutrition strategies, including how to manage macro minerals and antagonists within the diet. The panel discusses the importance of water quality and alternative magnesium sources. Additionally, they share effective calcium strategies for supporting fresh cows and reducing metabolic challenges. (11:36 – 16:48)

The panel then explores mineral interactions and balance, including the concept of mineral homeostasis and the role of skeletal calcium reserves. They challenge traditional thinking around calcium-to-phosphorus ratios. Furthermore, they examine key interactions between potassium, magnesium, and sodium that can impact absorption and overall animal health. (18:59 – 24:42)

As the episode continues, the discussion turns to the future of agricultural research, including the growing role of genomics in shaping nutrient requirements. The panel also addresses ongoing challenges in funding and education. Additionally, they discuss the broader influence of policy and corporate investment on the direction of scientific research. (26:03 – 32:43)

Attention then shifts to diagnostics and emerging tools, where the panel discusses biomarkers and enzyme-based approaches for tracking bioavailability. They also emphasize the importance of proper blood sampling timing. Additional topics include phosphorus binders, zeolite-based diets, and unanswered questions around the evolutionary role of magnesium. (33:48 – 38:34)

The episode concludes with a focus on holistic mineral management, emphasizing the importance of integrating scientific understanding into practical feeding decisions. The panel shares final insights and key takeaways for improving mineral nutrition programs. In summary, they also support long-term dairy cow performance. (41:20 – 42:38)

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The episode opens with introductions to the panel, including Kurt Cotanch, Gianni Raffrenato, Steve Martin, and Jacob Copeland, establishing a diverse mix of academic, applied, and field-based expertise in dairy nutrition and forage systems. (00:00 – 07:39) 

The conversation begins with a deep dive into forage quality, emphasizing the importance of harvest timing, speed, and efficiency. The panel discusses how mold and yeast contamination can compromise digestibility—both in the lab and in the rumen—and how improving harvest practices can significantly impact overall feed value. (07:39 – 12:35) 

From there, the discussion broadens to regional feeding strategies, comparing dairy systems across environments such as the Northeast and Western U.S. The panel highlights how forage availability, climate, and production goals influence diet formulation, and how nutritionists adapt fiber strategies to maintain performance under very different conditions. (12:36 – 17:31) 

Attention then turns to practical, on-farm evaluation tools, particularly the use of shaker boxes. While sometimes considered outdated, the panel reinforces their value in assessing particle size distribution, identifying ration inconsistencies, and helping bridge the gap between theoretical models and real-world feeding outcomes. (17:32 – 23:04) 

A significant portion of the episode focuses on troubleshooting fiber digestibility in nutrition models, particularly within NDS and CNCPS systems. The panel explores how to interpret digestibility values, adjust degradation rates, and calibrate models based on observed animal performance—while also emphasizing the importance of accurate inputs, including feed descriptions and animal data. (25:27 – 32:10) 

The conversation also highlights the complexity of fiber as a nutrient, discussing concepts such as undigested NDF pools, passage rate, and the interaction between physical and chemical fiber characteristics. The panel reinforces that while models provide structure, effective nutrition still requires experience, observation, and critical thinking. Finally, the episode looks ahead to the future of dairy nutrition, examining the growing role of artificial intelligence in ration formulation. While AI and large language models show promise, the panel raises important concerns about their ability to capture biological nuance, emphasizing that human expertise, on-farm observation, and scientific judgment will remain essential. (39:25 – 44:38) 

The episode concludes with key takeaways from each speaker, reinforcing the importance of responsible model use, accurate data inputs, and maintaining a strong connection between computer-generated rations and real-world cow performance. 

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The discussion opens with a welcome to the Real Science Exchange and an introduction to the expert panel, followed by foundational context around amino acid nutrition and its growing importance in dairy production systems. Early in the episode, the panel introduces the concept of feeding the “one-ton” component cow, highlighting the nutritional intensity required for high-output animals and comparing genomic potential with real-world feeding practices. (0:00–2:53) 

As the conversation develops, the panel emphasizes the importance of challenging traditional scientific assumptions and pushing the boundaries of dairy nutrition research. Practical, on-farm insights are shared through examples from Sunnyside Dairy, including consulting experience, environmental considerations, and feed quality management. The group also addresses stocking density and heat abatement strategies, reinforcing the relationship between cow comfort and production efficiency. (6:59–11:28) 

A shift toward performance philosophy introduces a high input–high output approach to dairy production, setting the stage for a deeper dive into amino acid research. The panel explores histidine as a potentially limiting amino acid and discusses its bioavailability, supported by both U.S. and global research perspectives. The conversation also covers the role of low-protein diets and how they influence histidine responses in modern dairy systems. (13:16–18:34) 

Attention then turns to rumen function and feeding stability, with a focus on total mixed ration (TMR) consistency and its impact on production outcomes. The panel explains methods for evaluating amino acid bioavailability and rumen protection, bridging the gap between controlled research and practical application on commercial dairies. (20:10–21:16) 

During an extended audience Q&A, experts provide actionable strategies for managing high metabolizable protein diets in fresh cows, along with day-to-day feeding practices that support consistency. The discussion highlights ongoing challenges with maintaining accurate data and ensuring feeding precision, both of which are essential for optimizing herd performance. (23:23–31:49) 

The episode then transitions into performance measurement and economic considerations. Panelists examine the biological drivers of milk production and discuss how to evaluate feed additives and nutritional strategies in commercial settings. Emphasis is placed on maintaining economic discipline in on-farm research, with Milk Urea Nitrogen (MUN) presented as a valuable metric for assessing protein efficiency. (34:50–38:48) 

Further exploration of protein nutrition includes discussion on casein and whey contributions to high-yield production, amino acid interactions, and differences in European feeding limits and regulations. The panel also reviews the role of lysine in fat synthesis and de novo milk fat production, along with sourcing challenges related to histidine and variability in protein ingredients such as blood meal digestibility. (40:51–50:54) 

As market dynamics come into focus, the group evaluates the value proposition of different protein sources and how nutrition strategies must adapt to economic fluctuations. These insights highlight the importance of balancing cost, performance, and efficiency when formulating rations in a changing market environment. (54:21–55:30) 

In the closing portion of the episode, the panel addresses final audience questions and discusses the benefits of precision release methionine technologies in supporting production efficiency. The conversation wraps up with forward-looking insights into dairy nutrition, including opportunities in fresh cow management and the ongoing interaction between genotype and feeding strategies. (58:22–1:05:48) 

The episode concludes with key takeaways and additional resources for continued learning through Balchem ANH’s Real Science Exchange podcasts and webinars, providing listeners with access to further insights on dairy nutrition and innovation. (1:07:53) 

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Recorded live at the Florida Ruminant Nutrition Conference, this episode of the Real Science Exchange explores how improving nitrogen efficiency can enhance both dairy performance and environmental sustainability. Featuring Dr. Kelly Nichols (UC Davis), Dr. Jonas de Souza (Perdue Animal Nutrition), and Dr. Ben Wenner (Feed Works), the conversation brings together leading perspectives on how nitrogen utilization continues to shape modern dairy nutrition programs.

The episode opens with a welcome to the Real Science Exchange and introductions to the panel, including Steve Martin, Maria Spindola, Stephanie Hansen, and Dr. Bill Weiss, setting the stage for a deep dive into mineral nutrition. (00:00 – 02:19) 

The discussion begins by comparing NASEM requirements with practical feeding recommendations, emphasizing how minimum requirements are designed to prevent deficiency—not maximize productivity. The panel explores how nutritionists incorporate safety margins and manage risk in formulation, including considerations around mineral toxicity and environmental impact. (04:21 – 08:19) 

From there, the conversation shifts to real-world application, highlighting the challenges of measuring mineral absorption and translating formulation strategies into on-farm execution. The panel discusses feeding logistics and how variability in mixing, delivery, and intake affects outcomes in dairy nutrition programs. (08:19 – 09:58) 

Attention then turns to specific minerals, including copper and iodine, and the role of antagonists in reducing mineral availability. The speakers discuss the risks of overfeeding inorganic minerals and the dairy industry’s evolving approach to copper supplementation, along with the broader implications for animal performance and human health. (12:44 – 18:44) 

The panel also explores diagnostic tools and testing methods, including feed, water, and forage analysis, as well as more advanced techniques like liver biopsies. They highlight the importance of understanding molybdenum levels, ash content, and other factors that can influence trace mineral balance and absorption. (20:32 – 27:54) 

As the conversation continues, the focus shifts to optimization strategies—connecting mineral nutrition to health outcomes like hoof integrity, antioxidant status, and overall performance. The role of selenium, vitamin E, and structured testing approaches are discussed, along with practical tools nutritionists can use to evaluate and refine feeding programs. (31:14 – 41:45) 

The episode also examines water quality and background mineral contributions, emphasizing how often-overlooked sources can impact total mineral intake. A deeper dive into mineral requirements and sources follows, including emerging insights on manganese, differences between beef and dairy systems, and key areas for future research. (43:37 – 49:52) 

Finally, the panel tackles the ongoing debate around sulfate trace minerals and their potential effects on fiber digestibility and nutrient utilization. The episode closes with a discussion on alternative mineral sources, cobalt and vitamin B12 requirements, and key takeaways for building more precise, performance-driven mineral nutrition programs. (51:21 – 58:12) 

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Yeast supplements play a critical role in modern animal nutrition, gut health, and feed efficiency, but not all yeast products work the same way. In this episode of the Real Science Exchange, recorded live at IPPE in Atlanta, Dr. Melina Bonato of ICC Animal Nutrition breaks down the science behind yeast supplements, yeast cultures, and pure yeast products, and explains how different yeast types are produced, processed, and applied across species.

The discussion covers yeast functionality in the gut microbiome, differences between autolyzed yeast, hydrolyzed yeast, and yeast cell walls, and how nutritionists and producers can select the right yeast solution for swine, piglets, and animals in high‑stress production phases such as reproduction and transition. The episode concludes with practical guidance on matching yeast supplements to production goals for improved animal performance and health.

⏱️ Episode Chapters

00:00 – Welcome and Guest Introduction
Recorded live from IPPE, the episode opens with an introduction to Dr. Melina Bonato and her expertise in yeast research and animal nutrition.

01:06 – Dr. Bonato’s Academic and Professional Journey
Dr. Bonato shares her education, research background, and career path in yeast-based nutritional solutions.

04:30 – The Evolution of Yeast in Animal Nutrition
How yeast products have evolved over time and why their role continues to expand across species.

07:35 – Introduction of Graciella Valini
Graciella Valini joins the conversation, adding perspective to the discussion.

09:27 – Yeast Functionality and the Microbiome
An overview of how yeast interacts with the gut microbiome to support animal health.

10:54 – Defining Different Types of Yeast
Key differences between yeast products used in animal nutrition and how they are classified.

13:09 – Processing Yeast: Autolysis and Hydrolysis
How processing methods influence yeast structure, functionality, and application.

15:24 – Components of Yeast: Cytoplasm vs. Cell Wall
What’s inside yeast cells and why different fractions play distinct nutritional roles.

17:24 – Yeast Culture vs. Pure Yeast
Clarifying the differences between yeast cultures and pure yeast products.

18:48 – Identifying the Problem to Solve
Why clearly defining the nutritional or production challenge is critical before selecting a yeast solution.

20:24 – Yeast Solutions for Swine and Piglets
How yeast can support gut health and performance in young animals.

25:08 – Targeting Reproductive and Transition Phases
Using yeast strategically during periods of higher stress and physiological change.

28:41 – Pure Yeast vs. Yeast Cultures in Challenging Conditions
Comparing how different yeast forms perform under stress or disease pressure.

30:51 – The Future of Yeast Research
Emerging research areas and what’s next for yeast in animal nutrition.

37:11 – Key Takeaways: Begin With the End in Mind
Final insights on aligning yeast selection with specific production goals.

38:34 – Matching Yeast Products to Production Goals
Practical considerations for choosing the right yeast product.

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Recorded live at the Florida Ruminant Nutrition Conference, this episode of the Real Science Exchange features Drs. Heather White and Brad Johnson exploring the role of maternal choline nutrition and its emerging impact on beef × dairy calf performance. 

Maternal nutrition plays a powerful role in shaping beef quality outcomes. In this episode, Dr. Heather White explores how maternal choline supplementation influences fetal muscle development, marbling, feed efficiency, and tenderness—providing new insight into value creation for beef × dairy systems. 

⏱️ Episode Chapters 

0:00 – 2:18 | Unlocking Marbling: Why Maternal Nutrition Matters An overview of how maternal choline supplementation during gestation can influence carcass quality and marbling in offspring. 

2:18 – 8:50 | The Science of In‑Utero Programming and Muscle Development How fetal programming affects muscle fiber formation, intramuscular fat deposition, and long‑term beef quality. 

8:50 – 12:32 | The Economic Multiplier: Why Early Choline Investment Pays Off Connecting maternal nutrition to downstream economic returns through improved performance and carcass value. 

12:32 – 21:33 | Boosting Feed Efficiency: Lessons from Argentina’s Receiving Trials Real‑world data showing how early nutritional strategies influence feed efficiency and growth during receiving and backgrounding. 

21:33 – 26:59 | Muscle Physiology and Tenderness A deeper look at how muscle development impacts tenderness and eating quality. 

26:59 – 33:33 | The Future of Branded Beef Programs How maternal nutrition insights may shape branded beef strategies and differentiated beef × dairy value chains.

This episode of the Real Science Exchange features Dr. Mary Beth Hall, founder of The Cows Are Always Right and former USDA‑ARS scientist, discussing her highly attended Real Science Exchange webinar, Manure Evaluation: Figuring Out What’s Going On Between Cows and Their Rations. Joining the pub‑table conversation are Dr. Clay Zimmerman, Dr. Stefano Vandoni, and Dr. Sion Richards. Dr. Mary Beth Hall explains why manure evaluation is one of the most reliable diagnostic tools in dairy nutrition, providing a direct biological response that may not appear in ration models or performance data. She emphasizes why manure must be evaluated alongside cow behavior and production metrics. (09:28) Mary Beth breaks down the science of fecal pH, including how to measure it correctly, why results can be misleading if done improperly, and what fecal pH reveals about digestion beyond the rumen. She explains why fecal pH does not directly reflect rumen pH and how fiber source influences hindgut fermentation. (14:46) The discussion shifts to practical manure screening on farm. Mary Beth explains what to look for when rinsing manure, how undigested fiber or grain can signal rate‑of‑passage and feed processing issues, and why screening is best used as a qualitative diagnostic tool rather than a strict numerical benchmark. (21:36) The panel compares manure evaluation with rumination monitors and emerging dairy technologies, highlighting why sensor data must be interpreted in context with manure consistency, cow behavior, intake patterns, and diet composition to accurately assess cow health. (28:16) Real‑world troubleshooting examples illustrate how ration and management issues—including spoiled silage, feed sorting, inconsistent intake, and water quality problems—often appear first in the manure. Variation within a pen is discussed as an early warning sign for nutrition challenges. (42:14) In closing, the group reinforces why manure evaluation remains underutilized despite being one of the clearest biological indicators of cow health. Integrating manure observation with cow comfort, rumination, feeding management, and overall herd behavior is critical for better nutrition decision‑making. (46:34) Please subscribe and share this episode with your industry colleagues and invite them to join us at the Real Science Exchange virtual pub table. Be sure to register for upcoming Real Science Lecture Series webinars to continue the conversation. Finally, if you’d like a Real Science Exchange t‑shirt, screenshot your rating, review, or subscription and email it to anh.marketing@balchem.com with your size and mailing address, and we’ll send one your way.

This episode of Real Science Exchange was recorded live at the 2026 IPPE Show and focuses on the newly formalized IFEEDER Research Submission Program and its role in advancing innovation across the animal feed and pet food industries. 

Lara Moody, Executive Director of the Institute for Feed Education and Research (IFEEDER), opens the discussion by outlining IFeeder’s mission to advance understanding and trust in a sustainable animal feed and pet food supply chain. Founded in 2009, IFEEDER has steadily expanded its scope of work, recently releasing key industry resources including feed ingredient consumption reports, a comprehensive pet food ingredient report covering more than 600 ingredients, and a strategic assessment of vitamins and amino acids related to U.S. food security. (0:46) 

Lara then introduces Dr. Yan‑Tai Hung, IFeeder’s Senior Research Manager, whose background as a swine nutritionist brings additional technical depth to the organization’s research efforts. Dr. Hung discusses his experience in applied nutrition research and how IFEEDER is expanding beyond individual ingredients to address the broader animal food production chain and food availability challenges. (2:05) 

The conversation turns to IFEEDER’s funding model and organizational growth, with Laura explaining how the foundation has diversified beyond industry funding alone. Over the past five years, IFeeder has shifted from relying almost entirely on industry contributions to securing significant support through grants and partnerships with organizations such as the USDA, commodity groups, and other stakeholders—allowing annual project funding to grow substantially. (3:24) 

Dr. Chad Risley, Research Committee Chair, shares his long‑standing involvement with IFeeder and reflects on how the organization has evolved from early educational initiatives to a more focused, impact‑driven research foundation. He highlights the importance of IFEEDER’s sustainability toolkit and strategic planning in helping the organization gain momentum and relevance across the industry. (4:29) 

A major focus of the episode is the new IFeeder Research Submission Program, which formalizes how research ideas move from concept to funded projects. Previously, projects originated informally through committees and the board. The new process provides clear submission guidelines and evaluation criteria to ensure proposed projects align with AFIA priorities and deliver practical value to the industry. (8:39) 

The panel explains that while the submission process is newly approved, outreach is already underway with AFIA committees and industry stakeholders to encourage future submissions. With 14 AFIA committees representing diverse areas of animal nutrition, IFEEDER aims to ensure broad participation across the feed and pet food sectors. (11:28) 

Dr. Risley discusses how IFEEDER‑supported research has already driven regulatory and policy wins, including data used to demonstrate the economic impact of delayed feed additive approvals—a project that helped secure additional FDA resources to improve regulatory efficiency. (12:04) 

The discussion then shifts to collaboration with universities, where Laura emphasizes IFEEDER’s role as a bridge between academic research, industry needs, and nonprofit funding. By partnering with universities, IFEEDER helps align research proposals with real‑world challenges while strengthening grant competitiveness and knowledge transfer. (13:26) 

Looking ahead, the panel outlines research priorities for 2026 and beyond, including sustainability, foreign animal disease prevention, biosecurity risks, and improving communication around animal health and nutrition. Sustainability is framed not only as environmental stewardship, but as the long‑term viability and profitability of the animal feed and pet food industries. (16:21) 

Lara highlights strategic wins over the past five years, including the development of a formal strategic plan, increased industry visibility, and the creation of tools and datasets that support foot printing, feed formulation decisions, and industry advocacy. (18:59) 

The episode wraps up with discussion of IFEEDER’s feed consumption reports, which quantify the economic impact of the feed industry at state and congressional district levels. These reports have become valuable tools for educating policymakers and supporting science‑based advocacy efforts on Capitol Hill. (21:52) 

Final remarks encourage listeners to stay engaged with IFEEDER, subscribe to its newsletter, share research ideas, and support the foundation’s work through contributions and participation in its annual Day of Giving. (24:41) 

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This episode features Andrea Lendewig, Head of Research & Development at IFCN, discussing her Real Science Exchange webinar presentation Global Dairy Market Status and 2035 Perspectives. Joining the conversation are Philipp Goetz, Head of Sales and Business Development at IFCN; Lucas Fess, Senior Dairy Analyst with Rabobank; and Jeremy Painter, Vice President of Global Commercial Operations for Animal Nutrition & Health at Balchem. Together, the panel examines current milk production trends, regional differences, butter and protein markets, exports, herd dynamics, and what the next decade may hold for global dairy.

Andrea opens by outlining IFCN’s global dairy data network and explains how annual farm‑level data collection and monthly updates allow IFCN to monitor milk production, prices, and costs across major dairy regions. She highlights a major industry milestone: global milk production surpassing 1 billion tons, driven by growth across multiple regions. (04:40)

The discussion then turns to recent production trends. The panel explains how the U.S. has shown consistent strength, while the EU experienced slower growth early before unexpected late‑season increases. China and parts of Latin America continue to grow production but remain dependent on international markets. Weather, animal health, and strong milk prices aligned to create production surprises in several regions. (17:30)

Andrea and Lucas examine global milk price dynamics, focusing on the growing divergence between butter and cheese prices over the last decade. Butter prices have increasingly driven global milk price signals, influencing producer behavior and trade flows. One notable shift discussed is the U.S. becoming a net exporter of butter in 2025 after more than a decade as a net importer. (25:10)

The panel also explores rising costs of milk production. IFCN data show that milk production costs have increased sharply over the last five years, with roughly 75% of countries now facing costs above $40 per hundredweight. These pressures are influencing farm investment decisions, particularly in regions with stricter environmental regulations. (28:30)

Herd dynamics and beef‑on‑dairy economics are another key theme. Lucas and Jeremy describe how record beef prices have reshaped breeding decisions in the U.S., increased calf values, and encouraged producers to keep cows longer. This dynamic has contributed to U.S. herd growth and stronger-than-expected milk supply, raising the question of whether current production trends represent a new normal. (35:00)

The conversation contrasts structural differences between Europe, and the U.S. European producers face tighter environmental regulations, land constraints, and aging farmer demographics, limiting expansion. In response, many EU farmers are diversifying income through solar energy, agri‑tourism, and land leasing rather than increasing milk output. Both IFCN and Rabobank suggest 2025 may represent peak milk production for the EU under current conditions. (45:00)

Attention then shifts to exports and demand. Lucas outlines where U.S. dairy exports are growing—especially in Mexico, Asia, and emerging markets—and explains why exports will be critical as domestic consumption grows more slowly than production. The panel also discusses rising consumer interest in protein, from high‑protein milk and beverages to whey ingredients, and how this trend supports long‑term dairy demand. (51:00)

Looking ahead to 2035, Andrea and Philip share IFCN’s long‑term outlook. The U.S. is expected to drive most global production growth, while Europe trends closer to self‑sufficiency and Oceania remains export‑focused. Demand growth—driven by population increases and more westernized diets in Asia, Africa, and the Middle East—is expected to outpace supply growth, supporting higher dairy prices over time. (57:30)

In closing, the panel reflects on key takeaways: the importance of data‑driven decisions, diversification of farm income, continued productivity gains through genetics and technology, and strong long‑term fundamentals for dairy. While risks remain, the group agrees the global dairy sector is well positioned for the next decade. (01:02:00)

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Dr. Mike Van Amburgh begins by outlining how amino acid nutrition has historically been viewed almost exclusively through the lens of milk protein. He explains that emerging research clearly shows amino acids play far broader roles in the cow, influencing milk fat synthesis, energy metabolism, and overall efficiency. As genetic potential has increased, amino acids are now supporting many biological pathways beyond simple milk protein yield. (05:50)

The discussion quickly expands to nitrogen efficiency and environmental sustainability. Dr. Van Amburgh explains that dairy systems across Europe and North America are under increasing pressure to reduce nitrogen losses. By formulating more precise diets that better match amino acid requirements, cows can excrete significantly less urinary nitrogen while maintaining—or even improving—milk production, creating both environmental and economic benefits. (09:30)

An audience question shifts the conversation toward the challenge of quantifying amino acids in forages. The panel discusses the robustness of current CNCPS model libraries and explains why forage amino acid profiles tend to be relatively conserved. While management factors like heat damage or poor fermentation can alter availability, microbial protein ultimately supplies a large and consistent portion of metabolizable amino acids to the cow. (12:15)

Building on this, the panel explores where required amino acids actually come from. Dr. Van Amburgh emphasizes that microbial protein should supply roughly half of total amino acid needs, making rumen efficiency critical. However, as production levels rise, microbial protein alone is no longer sufficient—creating a clear role for rumen‑protected amino acids to close growing nutritional gaps. (16:20)

Dr. Usman Arshad then leads a deep discussion on choline and methionine in transition cows. He explains why these two nutrients are not interchangeable, despite both acting as methyl donors. Choline has a unique lipotropic role in supporting liver fat export and reducing fatty liver risk during early lactation, while methionine primarily supports milk production and protein synthesis. Research shows that choline supplementation during the transition period alone can generate lasting carryover improvements in milk yield later in lactation. (29:00)

The panel addresses a common industry question: how much choline is enough? Dr. Arshad reviews decades of research, including meta‑analyses showing a largely linear response between choline ion intake and milk production. While 12–13 g/day of choline ion remains the standard recommendation based on most available studies, data suggest additional benefits may exist at higher levels—even though more research is still needed. (34:00)

Attention then turns to amino acid nutrition in close‑up and fresh cows. Dr. Van Amburgh explains that recent infusion and feeding studies demonstrate much higher metabolizable protein requirements than traditionally assumed, driven in part by the important role of non‑essential amino acids. These nutrients support energy generation, glucose synthesis, and tissue metabolism during early lactation—contributing to substantial gains in energy‑corrected milk when requirements are met. (44:30)

The panel also discusses whether amino acid balancing can help cows cope with heat stress. While amino acids do not eliminate heat stress, improving metabolic efficiency appears to reduce wasted heat production and support immune function and gut integrity, potentially helping cows better navigate stressful conditions. (54:45)

From science to economics, producers raise questions about return on investment. The group shares real‑world examples showing that improving amino acid balance often increases milk components without increasing intake, frequently delivering returns of 2:1 or greater, depending on milk pricing and market structure. (58:00)

Dr. Van Amburgh then offers candid insights into rumen‑protected amino acid bioavailability, explaining that products on the market are not created equal. Independent testing has shown efficiencies ranging from as low as ~10% to as high as ~80%. The panel stresses that transparent, published bioavailability data are essential for accurate formulation and for maintaining credibility across the industry. (01:01:30)

A technical discussion follows on measuring amino acid bioavailability, comparing isotope dilution, selenium‑methionine, and in vitro approaches. The group agrees that no method is perfect, but understanding assumptions and applying methods consistently can produce reliable, actionable data. (01:06:00)

In the final phase of the episode, the panel examines modern high‑starch diets, monensin use, and intake regulation. Dr. Van Amburgh suggests many systems may now be producing excessive propionate, potentially limiting intake through chemical fill. He argues that rebalancing starch and NDF—rather than simply adding more concentrate—may unlock better efficiency and performance. (01:10:00)

The episode concludes with final audience questions and a call to rethink traditional nutrition paradigms. The panel emphasizes that precision amino acid nutrition—supported by sound science, verified bioavailability, and thoughtful diet structure—is becoming essential for meeting the production, economic, and environmental demands facing dairy systems today. (01:20:29)

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Dr. Baumgard opens by explaining the origin of the “immune suppression” theory in transition cows. Research dating back to the late 1970s showed slower neutrophil infiltration into the mammary gland in early lactation, which led to the assumption that cows are immunosuppressed after calving. This idea has shaped industry thinking for more than 40 years. (10:43)

He outlines two primary mechanisms traditionally blamed for immune suppression: the cortisol surge at calving, which may impair neutrophil migration, and the metabolic changes of early lactation—high NEFAs, ketones, and low calcium—which appear to reduce neutrophil function in laboratory settings. (13:16)

Dr. Baumgard then challenges the central assumption: are cows truly immunosuppressed, or are they simply exposed to greater pathogen loads and stressors during a narrow window around calving? He argues that morbidity may reflect increased environmental and physiological challenges rather than a dysfunctional immune system. (15:25)

Dr. Fry shares field data from three herds representing over 100,000 calvings. After implementing management changes—primarily building a well-designed transition barn with lower stocking density, improved hygiene, and better cow flow—metritis rates dropped from 21.3% to 9.7%. Nutrition and innate immunity remained unchanged, suggesting management and environment were key drivers. (21:29)

The panel discusses the role of stress stacking during the transition period. Dr. Baumgard explains that multiple simultaneous stressors, such as overcrowding, heat stress, hygiene challenges, social stress, and nutritional shifts, may overwhelm cows. He emphasizes growing evidence that stress compromises gut integrity (“leaky gut”), potentially triggering systemic inflammation and increasing susceptibility in tissues like the mammary gland. (27:27)

Heat stress provides another example. While mastitis rates often increase during humid Midwest summers, they decline in arid regions like Arizona and Israel despite severe heat stress. Dr. Baumgard suggests environmental pathogen load—not immune suppression—is the primary driver. (27:43)

The conversation shifts to ketosis and hyperketonemia. Dr. Baumgard and Dr. Pralle discuss how elevated BHB and NEFAs may not always indicate disease but instead reflect normal metabolic adaptation to support milk production. The key distinction is productivity: cows milking well with high ketones may not require intervention, while cows with high ketones and poor milk production warrant deeper investigation into underlying causes such as metritis, mastitis, hypocalcemia, gut inflammation, or environmental stress. (37:13)

Dr. Fry reinforces the importance of whole-cow and whole-environment evaluation rather than treating metabolic markers in isolation. Monitoring milk yield, rumination, activity, and cow demeanor—along with assessing stocking density, pen hygiene, hoof health, and stockmanship—are critical to identifying true problems. (44:00)

The group emphasizes reducing pathogen load through simple, practical management: minimizing manure accumulation, maintaining clean and dry bedding, improving calving hygiene, and lowering stocking density—especially for close-up and fresh cows. (33:39)

Looking ahead, Dr. Baumgard describes his lab’s focus on modeling “stacked stressors” to better replicate the real-world transition period. Rather than studying stressors in isolation, his team is investigating how combined stressors influence physiology, particularly gut health. (47:11)

In closing, the panel encourages industry professionals to reconsider the immune suppression paradigm. Instead of trying to “fix” the immune system at calving, the emphasis should shift toward removing stressors and minimizing environmental challenges that create excessive pathogen exposure. (53:01)

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Dr. Penner presented “Progress in the gut: What we know about ‘gut health’” to lead off the symposium. He highlights using rumen acidosis as a model for gut health, focusing on key structures and how paracellular permeability is maintained or dysregulated, absorptive function, and microbiology. He notes that rumen acidosis affects other parts of the gut besides the rumen. (4:52)

Dr. Laarman wrapped up the  symposium with “Gut health in ruminants: Where to from here?” He agrees with Dr. Penner that we need to look beyond the rumen at all other gut organs. His group has researched rumen acidosis in calves and how it’s linked to hindgut acidosis and pH dynamics. Calves behave very differently from cows in this model. Gut health begins from birth and is the whole tract, not just the rumen.  (7:35)

Work in Dr. Penner’s lab showed that inducing inflammation in the mammary gland actually tightened permeability in the GI tract, which was opposite of their initial hypothesis. Dr. Baumgard’s lab found similar results in a heat stress model, and Dr. Laarman echoes that his group has also found this result.  The panel discusses possible mechanisms of action. Dr. Penner explains that diet may also have an influence on gut permeability. (11:01)

The panel talks more about what we know and don’t know about gut health. We probably know which regions of the gut are most likely to be affected by challenges, what those impacts are, how fast those gut changes occur, and how nutrient absorption can be affected by challenges. The group hypothesizes that pH alone does not have a negative effect, but if low pH occurs at the same time as other signals or molecules, then pathology happens. Dr. Laarman shares some of the observations his group has made with calves, which withstand low pH that would kill a mature cow if she experienced it. (18:40)

Guests talk about some of the reasons why we know less about ruminant gut health compared to monogastric species. They also visit about the microbiome and how perhaps what the microbiome is doing and producing is more important than who all is present in the microbiome. (23:44)

Panelists share their take-home thoughts. (29:33)

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Recommendations for identification and selection of bioactive compounds to develop antimethanogenic feed additives. Dr. Yáñez-Ruiz (8:23)

How can we search for molecules that modify how feed is fermented in the rumen? Conventionally, we have used scientific literature to look for plant extracts and compounds that have been researched before. Now, we have computational technology that offers opportunities to model how molecules interact with rumen microbes. Once a candidate compound is selected, in vitro tools can be used to test dose responses before animal experiments. 

Recommendations for testing enteric methane-mitigating feed additives in ruminant studies.

Dr. Yáñez-Ruiz for Dr. Alexander Hristov (17:07)

Once compounds have been identified and selected, they need to be tested in the animal. These experiments are costly and best practices for experimental design, animals used, diets fed, delivery of the test compound, and measurement of methane should be followed. Some of these guidelines are strongly linked to the regulatory aspects that provide requirements for how in vivo trials need to be conducted. 

Feed additives for methane mitigation: Modeling the impact of feed additives on enteric methane emission of ruminants—Approaches and recommendations. Dr. Bannink (22:43)

Once experimental data is collected, it can be used to develop models to predict how effective an additive is, how it works, and its relevance. The intention is to quantify how an additive will work if you feed it to an animal. This can be complex due to variation among different datasets and natural fluctuation in methane production in the animal. One factor that plays a big role in the effectiveness of additives is the type of diet that animals are fed. 

A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants. Dr. Belanche (30:03)

Understanding the mechanism of action for methane mitigants is challenging. We know some compounds work to reduce methane, but we don’t know how or why they are working. There are five main types of additives when grouped by mode of action: modify rumen fermentation to decrease hydrogen production; methane inhibitors that act specifically against methanogens; inhibit enzymes common to all methanogens; hydrogen sinks to redirect hydrogen away from methanogenesis and toward other metabolic pathways; and promote methanotrophs that oxidize methane. The most effective are methane inhibitors, which decrease methane but don’t increase animal productivity. Combining a methane inhibitor with a hydrogen sink may help redirect hydrogen and result in improved animal productivity.

Regulations and evidence requirements for the authorization of enteric methane-mitigating feed additives. Dr. Tricarico (41:22)

There are as many regulatory systems as there are jurisdictions. Two concepts that are shared across jurisdictions are regulatory status/legal classification and intended use. While each jurisdiction requires some legal classification of a feed additive compound, each has a different criteria base from which they classify products. For example, “inhibitor” is a legal classification in New Zealand, but doesn’t even exist in other jurisdictions. Sometimes, the same word may mean different things in different jurisdictions. Authorization of a compound is not a blanket authorization, it is an authorization of the intended use of the compound. This specificity is critical for all involved to understand.

Feed additives for methane mitigation: How to account for the mitigating potential of antimethanogenic feed additives—Approaches and recommendations. Dr. del Prado (49:42)

A major challenge in this area is what kind of accounting system will be used: farm level, lifecycle analysis, carbon markets, national greenhouse gas inventories, etc. An accounting system needs to be well tailored from the type of experimental data available to the complexity used on the scale of the method. Experimental data, modeling, and accounting move hand-in-hand. 

Panelists share their take-home thoughts. (58:57)

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Dr. Nichols opens by outlining her background in protein nutrition research spanning Canada, the Netherlands, industry R&D, and now academia at UC Davis. Her research has focused on mammary amino acid metabolism, nitrogen efficiency, and the interaction between protein and energy supply in dairy cattle. (1:00–4:05)

Dr. Räisänen shares her path from Penn State to Finland, Switzerland, and now Aarhus University, where she is leading research within a large, multidisciplinary project focused on lifetime nitrogen efficiency in dairy systems. Her current work examines early lactation protein supply and rumen nitrogen balance. (7:32–10:07)

The discussion begins by establishing why protein nutrition plays a central role in sustainability. Ruminants are net protein producers, converting low-value feeds into high-quality milk and meat protein. However, inefficiencies in nitrogen utilization lead to urinary nitrogen excretion, contributing to ammonia emissions, nitrous oxide production, and nitrate leaching. Improving nitrogen efficiency, therefore, directly impacts environmental outcomes. (12:28–14:17)

The group discusses geographic differences in nitrogen regulation. European countries like the Netherlands and Denmark face intense scrutiny due to high livestock density on limited land. Similar regional challenges are emerging in concentrated U.S. dairy regions such as California’s Central Valley and parts of the Midwest. (15:17–18:19)

Dr. Nichols introduces the concept of metabolic flexibility—the ability of ruminants, and especially the mammary gland, to utilize different nutrients and metabolic pathways depending on supply. This flexibility helps explain why responses to protein supplementation are not always black and white, and why traditional limiting amino acid theory does not consistently predict milk protein responses. (24:58–26:23)

The conversation explores early lactation “protein boost” strategies inspired by post-ruminal amino acid infusion studies. Dr. Räisänen describes ongoing work using targeted concentrate supplementation to mimic infusion responses. Preliminary data suggest substantial early lactation milk yield responses, similar to infusion studies, when protein is delivered in a separate concentrate rather than blended into a TMR. (28:33–31:16)

Dr. Nichols discusses three key areas of flexibility highlighted in her webinar:

1. Energy source interactions (glucogenic vs. lipogenic supply),
   
    
2. Rumen nitrogen balance, and
   
    
3. Mammary gland amino acid metabolism. (32:21–33:50)
   
    

The panel explores how feeding systems may influence metabolic responses. PMR systems with separate concentrate feeding may allow temporal and metabolic “choice,” potentially improving efficiency compared to uniform TMR feeding. Robotic milking systems and automated concentrate feeders offer opportunities for more individualized protein nutrition strategies. (35:00–37:57)

Amino acid discussions highlight how flexibility challenges the traditional limiting amino acid model. Milk protein synthesis is not consistently limited by one amino acid, and mammary uptake patterns show that amino acids can serve multiple roles beyond direct incorporation into milk protein. Lysine, leucine, and histidine are discussed as examples of amino acids whose responses may vary depending on metabolic context. (41:07–45:25)

The group also examines energy source effects on nitrogen partitioning. Lipogenic diets (e.g., supplemental fats) may alter amino acid metabolism differently than glucogenic diets, but more research is needed to fully characterize these interactions. (49:24–53:11)

Dr. Räisänen emphasizes the importance of rumen microbial protein synthesis and improving prediction models for digestible amino acid supply. Better understanding and measurement of microbial protein output could significantly improve feed evaluation systems and nitrogen efficiency modeling. (54:04–56:05)

Dr. Nichols highlights endogenous nitrogen recycling and urea transport back to the rumen as another underexplored area. Improved mechanistic understanding of recycled nitrogen could refine models of rumen nitrogen balance and reduce overfeeding of dietary protein. (1:00:46)

The episode closes with a discussion of cow-to-cow variation in nitrogen efficiency and the potential for individualized feeding strategies to optimize the marginal efficiency of protein use. (1:02:00)

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Dr. Ricklefs-Johnson talks about bone health and the cardiovascular health benefits of cheese. Calcium, phosphorus, and vitamins D, K, and B12 are all important for bone health, and cheese is a good source of each. In the past, saturated fat in cheese would have been demonized, but research is finding that saturated fat isn’t created equally across all food types, and cheese has many unique fatty acids. Cheese consumption is associated with reduced risks of coronary heart disease, cardiovascular disease, and stroke. Cheese contains bioactive peptides that appear to help lower blood pressure. (4:18)

The panel discusses the mechanisms of action of cheese consumption on cardiovascular health, how much cheese is recommended daily, and whether different cheeses have different health benefits. Dr. Ricklefs-Johnson explains that the protein in cheese is primarily in the form of casein, rather than whey. Casein had been less utilized as it was thought harder to digest, but more research is showing the benefits of casein in muscle recovery and helping with sleep. (8:27)

Research supports that calcium from cow milk sources is more bioavailable compared to supplements or fortified calcium in plant milks. Cheese is also unique as a dairy food that contains vitamin K, which works in conjunction with vitamin D and calcium for maintaining bone mass. (15:07)

The panel visits about some of the other presentations at the symposium, including feeding cows to influence vitamin K or fatty acids in the milk and how to get the word out about the health benefits of cheese. (19:16)

Panelists share their take-home thoughts. (26:29)

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Dr. Rico’s presentation was titled “Of cows and bugs: Using insects as alternative feeds in dairy cattle nutrition.” He gives an overview of his presentation, noting that while insects are not a major focus of US dairy nutrition, they are of interest in other parts of the world as a protein source to substitute for soybean or fish meal. (2:12)

Dr. Dou’s talk was “Alternative feed for livestock: Opportunities and challenges to support a circular food system.” She explains that a typical agriculture/food system is linear: take, make, and waste, which generates a lot of food residues. Her research aims to recover and recycle some of the food residues from other industries and evaluate their suitability for livestock feeding. (3:51)

Dr. Pinotti’s presentation was titled “Alternative foodstuffs in dairy ruminant nutrition: Basic concepts, recent issues, and future challenges.” His research focuses on using “former food” for livestock feeding and feeding insects not only as a protein source but also as a potential mineral source. (5:38)

Dr. Pinotti talks about the challenges around variability in alternative feedstuffs. He goes on to describe some of the bakery byproducts he has used in research rations. He calls them fortified versions of cereal. They contain quite a lot of starch and also contain a lot of fat. These ingredients are ideal for young monogastric animals and also have utility in lactating dairy cow diets. The panel discusses the EU animal protein ban and whether similar restrictions exist for animal fats. (10:16)

Dr. Rico notes that insects contain between 40 and 70% protein, depending on the type of insect. Crickets, mealworms, and black soldier fly larvae are the most popular. The fly larvae have a higher fat content compared to crickets and are a good energy source for monogastrics like pigs, chickens, or fish. Less is understood about the feeding value of insects in ruminant diets, and Dr. Rico’s lab has been conducting experiments to help define this in dairy cattle. He notes the chitin content of insects is a unique challenge due to its indigestibility. It comes out in the NDF fraction in a nutrient analysis, but it is animal fiber, not plant fiber. (21:27)

The panel talks about the scalability of insects as a protein source and confirms that the theory that insects are a cheap protein source is different from reality at this time. The group talks about small-scale insect projects at universities and in Africa. (27:17)

Dr. Pinotti explains that insects are quite good at accumulating minerals, bad and good. His group conducted an experiment using sodium selenite as the substrate and the insects made selenocysteine and selenomethionine. Future research will include zinc as well as selenium in the substrate, and insects will be fed in an in vivo trial to verify bioavailability. He does not envision issues with chitin interfering with bioavailability since the insects incorporate the minerals into amino acids. (34:27)

Dr. Rico talks about the amino acid and fatty acid profiles in insects. Essential amino acid content is relatively similar to other common protein sources. Insects contain higher levels of lauric and myristic acids than other common sources which could pose a challenge for lactation diets. He explains that there is a low-fat source of black soldier fly larvae with around 12% fat, compared to 30% in the full-fat version. The panel talks about variability in protein and fat content by insect type and the substrate the insects were grown on. (37:35)

Dr. Dou describes some of her circular feed research using fresh cull fruit (kiwi, citrus, apples; delivered daily) blended into the TMR. Later, she also ensiled the fruit with dry hay in an effort to preserve the fruit before spoilage. Dr. Pinotti notes that he has used cull material from a salad plant as feed as well.  (44:31)

Dr. Dou reports that one-third of food produced for human consumption never makes it to the human stomach. Globally, it’s estimated that 1.6-1.9 billion tons of food are lost and wasted each year. The panel talks about the biggest challenges keeping us from using more former food products in livestock feeding. (50:54)

Panelists share their take-home thoughts. (59:51)

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This episode’s guests were speakers on a Hot Topic Panel titled “Farm Management for the Future - Managing for Health, Welfare, and Performance” at the 2025 ADSA annual meeting. 

Dr. Nelson gives some background on how the Hot Topic Panel idea came to be and introduces the rest of the guests. (1:07)

Dr. Devries describes his research program in dairy cattle behavior and nutrition, particularly using behavior as a metric for understanding nutrition and housing management and using automated tools. He has particular expertise in automated milking systems. He envisions incremental adoption of various automated tools to replace human labor in the manufacturing of milk. He predicts this will manifest not only in automated or robot systems, but also in increased automation in a traditional parlor system as well. (5:01)

Dr. Boerman, a nutritionist, collaborates with Dr. Amy Reibman, an engineer, at Purdue to research the use of video analytics on dairy farms. Projects include video prediction of cow intake and cow body weight combined with milk production information in an effort to make improvements in feed efficiency. She emphasizes that technology needs to be used across a large number of farms without disrupting the farm. The panel talks about what technologies are currently available, challenges in identifying individual cows, and specific issues created for technology in a dairy farm environment. Dr. Boerman notes that a collaborative effort with colleagues of different expertise leads to the most optimal outcomes. (15:42)

Dr. Giordano talks about monitoring systems for reproduction, health, and welfare. Wearable sensors are a good example of a technology that can be used to monitor both reproduction and health, as well as aspects of nutritional management. The goal of many research programs in this area is to touch cows as little as possible, yet intervene as early and intensely as possible with cows who truly need intervention. An intervention could be a treatment to ameliorate or reduce clinical signs, or it could be a preventative intervention that prevents the cow from developing a clinical health disorder. More work is needed to refine algorithms and integrate data, as well as distilling the data into what is most valuable to make the best predictions at the most reasonable cost.  (34:08)

The panel further discusses the challenges of data integration, adequate internet and power access on farms, human error for manual data entry, and future training challenges for dairy farm and allied industry employees.(38:32)

Panelists share their take-home thoughts. (52:26)

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Genetic resilience and the dynamics of inbreeding and diversity in dairy breeding. Dr. Maltecca (6:43)

The main issues in managing genetic diversity in dairy cattle include inbreeding depression and continuing selection without exhausting the available variability in the population. These are difficult to investigate in a breeding population, as there is not a model algorithm where there is the luxury of designing an experiment. Dairy cattle closely resemble one another, so it is difficult to distinguish between the effect of selection from the effect of drift and the effect of deleterious mutation accumulation in the population. Researchers find proxies to estimate inbreeding and inbreeding depression because we don’t have good estimates of dominance effects.

Identifying genetic diversity within indigenous and highly commercialized breeds for improved performance and future preservation. Dr. Huson (12:24)

Dr. Huson covered four steps of thinking about genetic diversity in cattle: characterization of the genetic diversity, biological understanding of why we should preserve diversity, utilizing our understanding of diversity in breeding programs, and preserving and reassessing diversity over time. 

Harnessing indigenous African breeds for sustainable dairy production: Opportunities for crossbreeding to accelerate genetic improvement. Dr. Mapholi (16:52)

Dr. Mapholi emphasized the importance of tick and disease resistance for the sustainability of the African dairy industry. The indigenous African breeds had been overlooked due to small frame size and the perception they were not suitable for commercial farming, but they have excellent tick and disease resistance. Exotic breeds from the US and Europe struggled with the harsh environment. Crossbreeding indigenous and exotic breeds is allowing for simultaneous improvement in milk production and disease resistance. Genomics is particularly helpful to identify the best candidate breeds for crossing.

Genomic- versus pedigree-based inbreeding: 2 sides of the same coin. Dr. Macciotta (24:19)

It was thought that genomic selection would help in slowing the increase of inbreeding because we were looking at the DNA of the animal, not their pedigree. However, the traditional top animals were the population from which genomic selection began, and genomic selection shortens generation interval, so inbreeding continues to increase at a faster rate. Genomics offer new tools for investigating inbreeding, but there are 10-15 options to calculate inbreeding, all of which could provide a different answer. With pedigree selection, there is only one measurement of inbreeding. We are still investigating the best method for calculating inbreeding using genomic tools.

Managing genetic diversity: Strategies for sustainable livestock improvement. Dr. Baes (27:53)

Genomic selection has increased the speed at which animals become more related. There are negative implications of inbreeding, but today, the genetic and economic gains achieved through the current intense directional selection still far outweigh the inbreeding issues. No one knows where the edge of the cliff is, however. Dr. Baes envisions an international system one day where academia, AI companies, and producers all work together to understand and manage genetic diversity in livestock.

The panelists discuss key takeaways they got from the other speakers’ presentations and give perspectives on the topic of genetic diversity for their particular country and field of study. (34:58)

Panelists share their take-home thoughts. (46:10)

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Host Scott Sorrell begins the episode by setting expectations for a science-first conversation on chelated trace minerals, noting panelist affiliations while emphasizing that the discussion is grounded in research, not promotion. Stephen Ashmead, Senior Fellow for Chelates with Balchem, shares the origins of chelated mineral technology through Albion Laboratories, founded in 1956 by his grandfather, Harvey Ashmead, after recognizing challenges with mineral absorption. The conversation also introduces Dr. Bill Weiss of The Ohio State University and co-host Dr. Maria Spinola, who brings both veterinary and applied nutrition perspectives to the discussion. (00:08)

The panel explains chelated minerals from a chemistry standpoint, describing how organic ligands form stable ring structures around trace minerals, helping protect them from antagonists in feed and water. The discussion also extends beyond dairy into human nutrition, including examples such as magnesium and iron, highlighting how mineral interactions affect absorption across species. (09:20)

Dr. Weiss and Dr. Spinola discuss emerging research showing that mineral sources can influence rumen and intestinal microbial populations. The group also explores how inorganic minerals can accelerate the degradation of vitamins A and E in premixes, particularly over time and under heat, whereas organic minerals are largely inert and help preserve vitamin potency. (14:20)

The panel acknowledges the difficulty of trace mineral research due to limited biomarkers and subtle performance responses. They emphasize the importance of using averages for forage mineral contributions rather than relying on single samples, and caution against assuming zero mineral supply from forages. (25:00)

A candid discussion centers on over-supplementation, with consensus that many diets exceed trace mineral requirements, particularly for copper and vitamins. Dr. Weiss explains the difference between requirements and recommendations, noting that modest safety margins are justified to account for biological variability, but feeding two to three times the requirements increases cost and risk without clear benefit. (37:57)

The episode concludes with a warning against “too-good-to-be-true” organic mineral products, explaining why unusually high metal percentages often indicate inferior chemistry. The panelists emphasize that mineral quality, ligand structure and supplier credibility are important in the long term. The panel's final takeaways reinforce feeding minerals thoughtfully, enough to meet needs, but not in excess. Lastly, you need to consider the microbiome effects, vitamin stability and consistency in delivery when feeding these mineral products. (49:41)

Greg Nye introduces himself and Mountain View Dairy, where he manages three facilities and associated farm ground. He outlines the design and construction timeline of their fully enclosed feed center and shares the three primary benefits behind the project: reduced shrinkage, improved ration consistency, and enhanced employee safety. (1:41)

Greg explains how external receiving and intentionally separated traffic flows eliminate cross-traffic between loaders and delivery trucks, which significantly improves safety and efficiency. The group discusses early design considerations, lessons learned from other operations, and how “R&D” (rob and duplicate) helped shape the final layout of the facility. (2:32)

Scott and Walt introduce footage showing how feeds are received, stored, and staged. Greg walks through the grain elevator, unloading, conveyor systems, bay storage, and handling efficiencies that minimize ingredient touches. (5:03)

Greg explains how strategic ingredient placement and facility layout shorten cycle time for high-use ingredients while maintaining flexibility for premixes and specialty feeds. He then goes into inventory management strategies, including rotating bins, tracking shrinkage, and maintaining ingredient freshness. (6:32)

The conversation shifts to dust control and shrink reduction, highlighting the enclosed facility design and the use of an industrial baghouse system to recapture nutrients. Feed processing is simplified by reducing complex operations to just a few controls. Greg highlights the impact of reducing corn handling to a single touch and how it accelerated ROI.  (8:28)

Finally, Greg discusses ration delivery innovations, including feed staging on conveyors and a custom delivery box that allows multiple loads to be staged and delivered efficiently. He shares how learning from other operations and refining those ideas to fit their scale and how it played a critical role in designing a system that maximizes efficiency without sacrificing flexibility. (15:08)

As we look ahead, join us for the next Real Producers Exchange on Tuesday, February 17, 2026, featuring Skylar Gerke, an Arizona dairyman with Midwestern roots. Skylar brings a unique perspective on what it’s like to transition from Midwest dairying to operating in the West. Registration is now open at balchem.com/real-science or agproud.com/real-producer. And as always, thank you to Walt for riding shotgun once again, and to our loyal listeners—thanks for being part of the journey. (20:39)

This episode’s guests were speakers on the Joint ADSA-CSAS Breeding and Genetics Symposium:

Dairy Welfare—Breeding and Management Strategies at the 2025 ADSA annual meeting. 

Jessica’s talk was titled “Herd Sustainability Index: Using milk recording data to evaluate dairy herd sustainability.” This index provides a national percentile ranking benchmark for producers relative to sustainability from DHI data. The index evaluates ten indicators in four major categories: longevity and culling, feeding and production, heifers, and health. (2:51)

Dr. Vasseur’s talk was titled “Improving welfare through inclusive innovation: The story of WELL-E.” This inclusive innovation delivers data-driven solutions with and for the Canadian dairy industry by integrating stakeholder and domain knowledge with cutting-edge tools and methods of the improvement of animal and human welfare. (4:48)

Dr. Vasseur talks about the development of the Code of Practice for the Care and Handling of Dairy Cattle, which was published in 2023. This most recent code of practice included recommendations and requirements for more opportunities for movement for dairy cattle, particularly those in tie stall environments. Dr. Vasseur’s lab has conducted research in this area to help dairy producers with possible modifications of stalls and other recommendations to improve cow comfort. Jessica describes her master’s research in tie stall modifications. The guests go on to talk about how often cows in tie stalls bump into their stall, some proof-on-concept research looking at doubling stall size, and recommendations for cow comfort improvements in existing tie stall operations. (6:53)

Dr. Vasseur discusses the relationship between cow comfort and longevity. She also talks about the realities of converting a tie stall barn to a free stall barn. (20:12)

Jessica describes the indicators used in the Herd Sustainability Index in more detail. A minimum of six tests in the last 12 months with 50% of the cows being recorded are needed to calculate the index for a farm. Seven of the ten HSI indicators are required for the index to be calculated. She goes on to explain how producers can see their index compared to the rest of Canada as well as historical change in their index, and details an incentive program for high-indexing and most-improved herds. (24:07)

Dr. Vasseur talks about cow comfort and welfare comparisons among intensive dairy production countries. She envisions the development and implementation of technology to allow for more automation and reduced observer bias of processes such as lameness evaluation. (30:30)

So what is WELL-E? Dr. Vasseur gives some background and details about bringing together animal scientists, computer scientists, and stakeholders to develop cutting-edge tools for the improvement of animal and human welfare. (33:24)

Jessica talks about her PhD research in dairy cow behavior and pasture management. She conducted a study where pastures were mowed the morning of grazing compared to conventional grazing. Cows in the mowed pastures spent more time ruminating and drank more water, but no differences in milk production or milk components were observed. (38:02)

Panelists share their take-home thoughts. (43:07)

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Rob and Adrian share their family’s journey, from Dutch immigrant roots to managing large-scale dairy operations in California and Colorado, and discuss how communication, leadership structure and disciplined decision-making have helped them successfully scale their operation. The conversation also dives into lessons learned from facility design, sustainability initiatives and the launch of a consumer colostrum brand rooted in dairy science.

Rob and Adrian introduce themselves and share their family’s immigration story and early dairy roots in California, including how prior generations entered the U.S. dairy industry. (1:01)

The Diepersloot’s tell the story growth on their dairy operations, including expansion in California, the decision to diversify geographically and the opportunity that led them to build Wolf Creek Dairy in Colorado in 2017. (1:29)

Rob and Adrian describe how they build and empower a strong leadership team, emphasizing the importance of hiring the right people, expecting managers to think like owners, and conducting efficient and candid meetings that focus on the entire business. (6:25)

The conversation shifts to facility design and operational successes in Colorado, including no-headlock systems, sort gates, feed efficiency improvements, and later adopted in California. (9:59)

Sustainability initiatives are explored, including methane digesters, power generation, manure management and solar energy projects, with a comparison of approaches between California and Colorado. (11:10)

Rob and Adrian share lessons learned from technology challenges, including manure handling systems, activity collars, and feeding infrastructure, and how those experiences shaped future decisions. (15:46)

The discussion turns to the origin of WonderCow Nutrition, detailing how academic research on colostrum and personal family experiences led to the launch of a consumer colostrum brand in 2023. (17:47)

Rob explains WonderCow’s calf-first sourcing commitment, how colostrum is collected responsibly, and what differentiates whole colostrum products from skim-based alternatives. (20:19)

The episode concludes with a preview of the exclusive “Back 30” live Q&A, available only to live webinar attendees, and a reminder of upcoming Real Producer Exchange events including the next one on February 17 with Skylar Gericke out of Arizona which will focus on reproduction success and heat stress. (23:23)

In the Real Science Exchange Legacy Series, we celebrate the pioneers who have shaped the dairy industry. In this episode, we honor Dr. Don Beitz, a distinguished professor at Iowa State University. At the 2025 ADSA Annual Meeting, a symposium was held titled “Donald C. Beitz Recognition Symposium: 50-Plus Years of Dairy Science Research.” The guests on this episode, all former graduate students of Dr. Beitz, were speakers at the event. Join us as we explore Dr. Beitz’s contributions and enduring impact on our industry. 

Panelists introduce themselves and how they met Dr. Beitz. Tricky MS and PhD exam questions are also shared. Panelists emphasize Dr. Beitz’s love for biochemistry, teaching, and collaboration. (1:17)

Dr. Beitz shares about his early life, academic career, and family. (11:45)

Dr. Goff’s symposium presentation focused on Dr. Beitz and colleagues’ contribution to our understanding of transition cow hypocalcemia. He talks about studies on low calcium diets, investigating the metabolic pathways of vitamin D, and low phosphorus diets. Dr. Beitz also studied the impact of vitamin D on meat tenderness. (22:37)

Dr. Nelson’s presentation detailed the advances in understanding bovine immunology from the work of Don Beitz and his colleagues. From the milk fever vitamin D research, it was also discovered that vitamin D had an impact on the immune system, which led to further work with vitamin A and immunity as well. Dr. Beitz also had students investigate calf growth rate influence on immune system development as well as Johne’s disease. (27:22)

Dr. Drackley focused on Dr. Beitz’s work in understanding fatty liver and ketosis. The transition period was of interest to Dr. Beitz, which is reflected not only in his work in hypocalcemia, but also the lipid and carbohydrate metabolism of ketosis. Dr. Beitz and his colleague, Dr. Young, developed a successful ketosis model using a slight feed restriction and supplementing a ketone body precursor, which was used to investigate ketosis and fatty liver. (30:25)

Dr. VandeHaar spoke about Dr. Beitz’s passion for research and teaching in dairy science, biochemistry, and life. He emphasized the depth and breadth of Dr. Beitz’s work and teaching. He shared that Dr. Beitz has served as major professor for around 107 graduate students and has taught biochemistry to over 16,000 students. (35:02)

The panelists share stories about Dr. Beitz’s humility, care and support for students, and the many different professional societies he has been involved in over his career. (38:39)

Panelists share their take-home thoughts. (42:56)

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This episode features Dr. Glen Broderick and Dr. May Beth Hall, speakers at the 2025 ADSA Ruminant Nutrition Symposium: Anomalies in Analyzed Nutrient Composition of Feedstuffs.

Dr. Broderick’s presentation was titled “Protein analysis methodology.” The high points of his talk include recommendations for nitrogen analysis in feeds, potential improvements in determining protein degradability and undegradability in the rumen, and near-infrared spectroscopy (NIR) analysis of amino acid composition of feedstuffs. (7:57)

Dr. Hall’s presentation was titled “Success and continuing challenges in analyzing nonfiber carbohydrates.” She gives some history of the analysis of non-fiber carbohydrates and talks about starch assays and how water-soluble carbohydrates are not solely composed of sugars. She also explains how microbes make decisions on which substrates to ferment and which to store for later. (12:47)

The panelists talk about challenges in obtaining real-time nutrient analyses in order to make ration changes. They recommend using rolling averages rather than a single sample and using milk urea nitrogen as a way to evaluate if something is not quite right with a ration. (21:17)

Dr. Broderick notes he recommends that scientists no longer use the Kjeldahl method of nitrogen analysis, that we look for new or alternative methodology other than in situ digestibility to determine protein degradability, and that NIR analysis of amino acids be used to make ration decisions when calibrated for the feedstuff under consideration. (27:10)

Dr. Hall recommends using the appropriate carbohydrate standard when measuring water-soluble carbohydrates: sucrose for fresh forages, fructose for cool-season grasses with high fructan content,  etc. She also notes that some feeds, like bakery waste or amylase-modified grain, contain soluble starch, which shows up in both the starch category and the water-soluble category in a feed analysis, essentially double-dipping. Lastly, she suggests that nonfiber carbohydrates remain a bit of a nutritional black box and we continue to learn more with improved technology.   (29:36)

Panelists share their take-home thoughts. (43:31)

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This episode features Dr. Jocelyn Johnson with STgenetics, a speaker at the 2025 ADSA Breeding and Genetics Symposium: Creating Carbon-Friendly Cows and Leveraging Omics to Improve the Sustainability of Dairy Production.

Dr. Johnson’s presentation was titled “Advancing dairy sustainability through feed-efficient genetics and genomics: Research insights and applications.” She gives an overview of her talk, which focused on data STgenetics has collected and how the company has applied that data to help their customers be more sustainable. She goes on to describe some of the residual feed intake research they’ve conducted in dairy cows. (4:20)

STgenetics has invested in feed efficiency technology and has shown that selection for improved feed efficiency is correlated to a lower carbon footprint. Dr. Johnson talks about the heritability of feed efficiency compared to other traits we select for in the dairy industry.  (8:16)

Dr. Pralle asks Dr. Johnson if STgenetics is measuring emissions from cows in their research. The company has partnered with Texas A&M to measure methane emissions in heifers divergently selected for feed efficiency. They found that more efficient animals produced less methane. Since that pilot project, STgenetics has purchased equipment to measure emissions at their own research facilities and has collected 2-3 years of data on beef, beef on dairy, and Holstein populations. Dr. Johnson emphasizes that the relationship between methane emissions and high milk production is somewhat of a balancing act. (11:29)

The group discusses feed additives purported to decrease methane emissions and the differences in rumen microbiomes between high and low efficiency animals. They also talk about how best to get information and technology in front of producers.  (17:59)

Panelists share their take-home thoughts. (23:39)

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Eve gives an overview of current and future consumer trends where dairy can play a role. Functional foods, health and wellness, high protein foods, fermented and cultured foods, women’s health, brain health, and aging are all part of the mix. (7:26)

The panelists discuss the healthfulness of saturated fats, the resurgence of butter, milk’s bioactive compounds, and how best to reach the public about the health benefits of dairy. (10:41)

Eve talks about marketing to Gen Z consumers, who are motivated by novelty. How do we reimagine a food that’s been here for thousands of years? What new ways can we talk about it? What ways can we optimize dairy science and research to show up in generative systems like ChatGPT? (20:34)

The group then tackles the topic of lactose. Lactose and honey are the only two sugars not made by plants. Why is it lactose that is in the milk of mammals? Dr. Jiminez-Flores thinks lactose is a dark horse in dairy and we have much yet to discover about it. He notes that some milk oligosaccharides are not digested by babies, but are used by bacteria in the development of a healthy microbiome. Dr. Lucy notes that dairy also contains peptides that have been found to reduce hypertension. The group also delves into how dairy products can be part of preventative health care. (23:53)

Do consumers perceive dairy products to be minimally processed? Eve explains that dairy is perceived as a clean, fresh food. Given the current trend to reduce additives and food dyes, she sees potential for dairy food science innovation in this area. Dr. Aldrich talks about the glycemic index of lactose-free milk. (38:13)

The panelists agree that dairy has a great upcycling story to tell. Converting fiber into milk and meat and feeding non-human grade byproducts are just two examples. Eve notes that younger consumers care about sustainability, but there’s a huge “say-do” gap: 76% of North American consumers identify as caring about conscious and sustainable practices, but less than 40% actually act on those values when making purchases. The panel also notes that whey is another great upcycling story. Dr. Jiminez-Flores emphasizes how important consumer trust in science and research is, and how we are currently experiencing a loss of that trust. (45:48)

Panelists share their take-home thoughts. (1:01:01)

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