Explore every episode of the podcast PhageLine

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the effect of an antibiotic and a probiotic on phage communities in swine gut microbiota as featured in a recent paper by Lemieux et al. in BMC Research Notes. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss Vitamin B12 release through bacteriophage-mediated cell lysis of a marine bacterium as featured in a recent paper by Sultana et al. in ISME Communications. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the synergistic effect of bacteriophages and fusidic acid against meticillin-­resistant Staphylococcus pseudintermedius in an ex vivo canine dermis model as featured in a recent paper by Ehling et al. in Veterinary Dermatology. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss Bacteriophage immunotherapy with artificial antigen-­directed immune labeling, as presented in a recent paper by Yao et al. in Science Advances. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world which is a recent paper by Wendling et al. in Briefings in Bioinformatics. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the anti-restriction functions of injected phage proteins, as presented in a recent paper by Silas et al. in Nature Communications. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the in vitro and in vivo selection and cost of bacteriophage resistance on natural Escherichia coli, as presented in a recent paper by Cardoso et al. in FEMS microLife. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage

This week, we will discuss the efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii to overcome phage resistance, as presented in a recent paper by Choi et al. in Microbiology Spectrum. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss a hydrogel with physically entrapped phages to control Pseudomonas aeruginosa infections in burn wound models, as presented in a recent paper by Walji et al. in Biomaterials Advances. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss a bacteriophage‑based virus‑like particle vaccine that induces cross‑reactive neutralising antibodies against porcine epidemic diarrhoea viruses (PEDV) by talking about a recent paper from Gu et al in Veterinary Research. Have fun!

This episode was generated using artificial intelligence.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss Phage-antibiotic synergy to combat multidrug-resistant strains of Gram-negative ESKAPE pathogens by examining a recent paper by Morris et al. in Scientific Reports. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the episode's contents.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the impact of microplastics on bacteriophage activity in aqueous environments by talking about a recent paper from Ochirbat et al. in the Journal of Physical Chemistry. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the episode's contents.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the bacteriophage potential of SARS-CoV-2 in human gut microbiota by talking about a recent paper by Petrillo et al in F1000. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the episode's contents.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss a method for the targeted discovery of bacteriophages by co-culture, called Phage DisCo, which was recently published in mSystems by Eleanor Rand and her colleagues at Harvard University. Usually, I would say "have fun" here; however, there is also a dark side to this episode: all five federal grants that supported different parts of this work were part of the mass termination of Harvard grants three weeks ago, as confirmed by principal investigator Michael Baym.

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the in vitro genomic characterization and pre-clinical evaluation of a new thermostable lytic Obolenskvirus phage formulated as a hydrogel against carbapenem-resistant Acinetobacter baumannii by discussing a recent paper by Sherif et al. in Scientific Reports. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss personalized inhaled bacteriophage therapy for treating multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis by talking about a recent publication by Chan et al in Nature Medicine. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss the effects of Phage–phage competition and biofilms on interactions between two virulent bacteriophages and Pseudomonas aeruginosa, which were recently published by Bürkle et al. in ISME. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will discuss PhageDPO, a machine-learning-based computational framework for identifying phage depolymerases, recently published by Viera et al. in Elsevier's Computers in Biology and Medicine. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will focus on the differences in phage recognition and immunogenicity in humans unraveled in a recent paper by Le et al. in the European Journal of Immunology. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will focus on optimizing phage engineering through an accelerated evolution platform by discussing a recent paper by Favor et al. from Nextbiotics Inc. in Scientific Reports. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will focus on 3D models for mimicking biofilms in diabetic foot ulcers for phage therapy. German researchers from Frankfurt and Jena recently reviewed this topic. The phage lab at the University Hospital Frankfurt was recently featured in Capsid & Tail for having built its own phage laboratory from scratch under very challenging conditions. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This week, we will focus on the mechanisms of tailed bacteriophage adsorption. For that, we will discuss a review from Storms and Sauvageau from the Department of Chemical and Materials Engineering at the University of Alberta, which was published in Elsevier's "Virology" in 2015. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. This week, we will focus on the applications of bacteriophage-derived endolysins for foodborne bacterial pathogens and food safety, a topic recently reviewed by Kahn et al. from Shenzhen University in Frontiers of Microbiology. Have fun!

#medicine #biology #bacteriophages #infection #amr #basicresearch #food #foodsafety

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. This week, we will focus on CRISPRi-ART, a method for functional genomics of diverse bacteriophages published by Benjamin Adler et al. from the University of California in Nature Microbiology at the end of February. Have fun!

#medicine #biology #bacteriophages #infection #amr #basicresearch #CRISPR #genomics #cas13

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. This week we will examine the synergistic action of mucoactive drugs and phages against Pseudomonas aeruginosa and Klebsiella pneumoniae. Have fun!

#medicine #biology #bacteriophages #cough #amb #nac #infection #amr

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. This week we will focus on the molecular basis of foreign DNA recognition by the BREX anti-phage immunity system. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.#medicine #biology #bacteriophages #bacteria #defense #infection #amr

Welcome to PhageLine. This week we will focus on a bacteriophage-based method for infection and thrombosis prevention using a phage-immobilized, nitric oxide-releasing surface. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

#medicine #biology #bacteriophages #devices #engineering #thrombosis #infection #amr

Welcome to PhageLine. This week we will focus on using specific phage proteins called endolysins instead of whole phages to fight bacteria by discussing the in vitro and in vivo efficacy of an engineered endolysin targeting Gram-negative pathogens. Have fun!

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. In this week's episode, we will focus on one of the biggest phage papers in 2024: a multicentre, multinational, retrospective observational study of personalized bacteriophage therapy outcomes for 100 consecutive cases headed by Jean-Paul Pirnay and Sarah Djebara.

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. In this week's episode, we will discuss bacteriophage-based biosensor technology by discussing the review Bacteriophage-based biosensors technology: Materials, fabrications, efficiencies and shortcomings (Haq et al., 2025 Biotechnology Reports).

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Welcome to PhageLine. In this week's episode, we will discuss the isolation and characterization of phages with clinical relevance from environmental sources.

This week's papers are:

1. Isolation of a lytic bacteriophage against extensively drug-resistant Acinetobacter baumannii infections and its dramatic effect in rat model of burn infection (Ghaznavi-Rad et al. 2022 JCLA)
2. Isolation and characterization of a lytic bacteriophage against Pseudomonas aeruginosa (Sharma et al. 2021 Sci Rep)

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.

Hello and welcome to PhageLine - your line to everything phage.

This podcast is where we discuss exciting research papers on bacteriophages once a week.

To get started let's get a general overview of the topic by talking through a review by Kortright et al. from 2019 (last author Paul E. Turner), titled "Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria".

This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents before publication.