Summary

At some point this medication may show its face on the pain boards.  Whether or not Suzetrigine will appear on the pain boards, all of us need to know about this new class of analgesic.

Brought to you by NRAP Academy, home of the PainExam Board Prep

Here, Dr. David Rosenblum delivered a comprehensive lecture about a new pain medication called Journavx (Suzetrigine). He discussed its mechanism of action as a NAV 1.8 receptor inhibitor, its clinical applications, contraindications, and dosing guidelines. Dr. Rosenblum emphasized that this non-opioid medication represents a new class of pain management drugs with no addiction potential. He also shared information about upcoming educational events, including ultrasound courses and various pain management conferences. The lecture included detailed information about drug interactions, safety considerations, and clinical trial results comparing Journavx to placebo and hydrocodone-acetaminophen combinations. Key findings from clinical trials showed that Jornavix achieved pain relief in 119 minutes compared to 480 minutes for placebo in abdominoplasty trials, and 240 minutes versus 480 minutes in bunionectomy trials. The recommended dosing is 50mg tablets twice daily, with an initial loading dose of 100mg. While the drug showed promising results for moderate to severe acute pain management, it did not demonstrate superiority over hydrocodone in clinical trials. Important contraindications include CYP3A inhibitors, and special considerations are needed for patients with hepatic impairment or those taking hormonal contraceptives. The medication should be taken on an empty stomach, either one hour before or two hours after food, and patients should avoid grapefruit juice while on this medication.

For more infomation....

Chapters Introduction and Upcoming Events

Dr. Rosenblum announced several upcoming events, including an ultrasound course in New York City on May 17th, 2025. He mentioned offering ultrasound and IV training for healthcare professionals, particularly nurses, ICUs, PAs, and hospital doctors. He also highlighted upcoming conferences including ASPN, Pain Week, Latin American Pain Society, New York, New Jersey Pain Congress, ASIPP, and EPA.

Introduction to Journavx (Suzetrigine)

Dr. Rosenblum introduced Suzetrigine (Journavx), a new 50mg tablet medication. He emphasized that this discussion was not sponsored by any pharmaceutical company but rather focused on educating about a new class of pain medication. He noted its potential importance as a future board examination topic.

Mechanism of Action

Dr. Rosenblum explained that Jornavx works by inhibiting the NAV 1.8 receptor. He detailed how the drug blocks sodium ions from entering pain-sensing neurons, disrupting action potential initiation and propagation. He emphasized that the drug is highly selective, binding over 31,000 times more selectively to NAV 1.8 than other NAV subtypes.

Contraindications and Drug Interactions

Dr. Rosenblum outlined various contraindications, particularly focusing on CYP3A inhibitors and inducers. He listed specific medications in each category and emphasized the importance of careful monitoring when prescribing Journavx alongside these medications.

Clinical Trial Results and Dosing Guidelines

Dr. Rosenblum presented clinical trial results showing Journavx's effectiveness in treating moderate to severe acute pain. He detailed the dosing guidelines: 50mg tablets twice daily, with an initial loading dose of 100mg. He emphasized the importance of taking the medication on an empty stomach and avoiding grapefruit juice.

Q&A

No Q&A session in this lecture

Summary

The video covers a conversation between Dr. David Rosenblum and Dr. Hamed Sadeghipour, discussing board preparation experiences and the current state of pain management practice. Dr. Rosenblum begins by announcing upcoming events, including a May 17th ultrasound course in New York City and his lectures at various conferences. He also mentions shadowing opportunities at his office. Dr. Sadeghipour shares his board preparation experience, discussing three main resources he used: Huntoon book (800 questions), Board Vitals (700 questions), and Pain Exam. He achieved notably high scores using these resources. Regarding his current practice, Dr. Sadeghipour describes working both in academic anesthesia (40-50% time) and private pain practice, managing four offices with four nurse practitioners.   The discussion then shifts to the changing landscape of pain management, with both doctors noting concerning trends: increasing focus on surgery center procedures over office-based ones due to reimbursement differences, the challenge of maintaining competency in advanced procedures, and competition from non-specialists entering the field. They also discuss the future of the specialty, suggesting it's moving toward becoming a hybrid of neurosurgery and orthopedic surgery with traditional pain management procedures.

 

For pain medicine Board Prep go to NRAPpain.org

For ultraound training go to NRAP Academy

Highlights Introduction and Upcoming Events

Dr. Rosenblum introduces the podcast and announces several upcoming events, including an ultrasound course in New York City on May 17th, appearances at ASPN and Pain Week conferences, and opportunities for shadowing at his practice.

Board Preparation Experience Discussion

Dr. Sadeghipour details his board preparation strategy using three main resources: Huntoon book (800 questions), Board Vitals (700 questions), and Pain Exam(700 questions videos, lectures, ultrasound training, regenerative medicine training and more). He explains the strengths and limitations of each resource and mentions achieving exceptionally high scores.

Current Practice Structure

Dr. Sadeghipour describes his dual practice model: 

Evolution of Pain Management Practice

Both doctors discuss the shifting landscape of pain management, noting increased focus on surgery center procedures, reimbursement challenges, and competition from non-specialists. They address concerns about fellowship training adequacy and the financial pressures affecting new practitioners.

Future of Pain Management Specialty

The discussion concludes with perspectives on the specialty's future, suggesting it's evolving toward a combination of minimally invasive spine surgery and traditional pain management, with concerns about maintaining specialty integrity and the need for stronger regulatory oversight.

Podcast Show Notes Episode Title: Optimizing Genicular Nerve Chemical Ablation: Insights from Dr. David Rosenblum Episode Summary:

In this episode, we are joined by Dr. David Rosenblum, a New York-based interventional pain physician, who discusses optimizing genicular nerve chemical ablation. Dr. Rosenblum shares insights as well as his upcoming ultrasound course schedyke in New York City, focusing on regional anesthesia, interventional pain, and IV ultrasound placement. He emphasizes the significance of ultrasound in enhancing pain management procedures and the latest advancements in the field.

Key Topics Discussed:

• Overview of Dr. Rosenblum's upcoming ultrasound courses in NYC, including regional anesthesia and IV ultrasound placement. More information can be found here or at NRAPpain.org.
• The role of ultrasound in interventional pain management, specifically in optimizing genicular nerve chemical ablation.
• Discussion on the recent study comparing genicular nerve phenol neurolysis and radiofrequency ablation.
• Importance of updating anatomical targets for pain management.
• Recommendations for expanding the number of targets in pain interventions.
• Insights on the safety and efficacy of chemical neurolysis versus radiofrequency procedures.
• Challenges and considerations in performing neurolytic blocks.
• Future directions in personalized treatment for chronic pain patients.

Featured Article:

Dr. Rosenblum references an article from The Korean Journal of Pain discussing the optimization of genicular nerve chemical ablation. Key takeaways include:

• The evolution of anatomical understanding related to genicular nerves.
• The recommendation to consider multiple targets for pain management instead of the traditional three.
• The need for careful patient examination to map pain effectively before intervention.

• Discussion on Knee Pain Management

  • ArticlebyAndresRochaRomero:
  • Discussion on knee pain targeting genicular nerve ablation.
  • Co-authored by Tony Ng and King K Stanley Lam.
  • Published in Korean Journal of Pain.
  • Highlights differences in pain management practices outside the U.S.

  Other Points on Genicular Nerve Chemical Ablation discussed

  • Phenol ablation being used more internationally vs. radiofrequency ablations.

  • Considerations for more extensive targeting of genicular nerves:
    • Importance of the median branch of the nerve to the vastus intermedius. • Expansion of targeting to include 6 nerves, not just 3.
    • Anatomical variations require different approaches.

    Recommendations and Observations

    • Importance of considering patient-specific anatomy and pain. • Repeat procedures and rehabilitation:

    • Concerns about bio intensity and fascia integrity.
    • Emphasizes muscle strengthening exercises to support knee.

  • CRPS Considerations:
  • Elderly patients may develop CRPS post-knee replacement.
  • Importance of lumbar sympathetic block in diagnosis and treatment.

Host Bio:

Dr. David Rosenblum, MD is an interventional pain physician based in New York City. With extensive experience in pain management techniques, Dr. Rosenblum is dedicated to advancing the field through education and innovative practices. He is particularly focused on the integration of ultrasound technology into pain management procedures.

Course Information:

Dr. Rosenblum's upcoming ultrasound courses are CME supported, monthly hands on workshops to give clinicians experience with ultrasound imaging to identify targets for nerve block joint injection, soft tissue injection and more..

• Monthly IV Ultrasound Course in Manhattan:
• Ideal for nurses, PAs, anesthesiologists, ER docs.
• Provides practice with phantoms, short lecture on IV ultrasound. • Offers CME credits.

• Ultrasound Courses:
• Held one Saturday a month, mostly in New York, but travels if needed. • Upcoming dates: December 21st, January 11th in Manhattan.

• Presentation Invitation at Pain Expo in Dubai: April 26-27. •  

• Next LAPS conference in September in Chile.

Call to Action:

• Subscribe to our podcast for more episodes on advancements in pain management.
• Follow us on social media for updates on upcoming courses and events.
• Share this episode with colleagues who may benefit from learning about ultrasound techniques in pain management.

 

 

 

Upcoming Opportunities and Closing Remarks

• Dr. Rosenblum encourages attending his ultrasound courses and conferences.

• Mention of upcoming conferences in ASPN inMiami, Pain Expo in Dubai, and  LAPS inChile.

• Recommendations to subscribe to newsletters for updates and free info.

• The podcast aims to support pain management professionals.

SIS Guidelines on COVID Vaccination & Steroid Injections

Regional Anesthesia Virtual Training Sunday March 14, 2021...

Dr. Rosenblum discusses the precautions recommended by the Spine Intervention Society. Concerns addressed:

• How soon after a Covid vaccination can I get a steroid injection?
• How long after a steroid injection can I get a COVID Vaccination?
• Is it dangerous to get a steroid injection during the vaccination period?
• Does a steroid injection render the COVID Vaccination ineffective?

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Upcoming Ultrasound Training Workshop Event Schedule-

March 14, 2021-
Ultrasound Guided Regional Anesthesia for Anesthesiologists-

https://painexam.com/events/march-14-2020-anesthesiology-ultrasound-course-regional-anesthesia-acute-pain/

April 18, 2021-
Live Ultrasound Training in NYC for Pain and Regional Anesthesia-

https://painexam.com/events/in-person-live-ultrasound-training-april-18-nyc/

May 16th, 2021-
Advanced Ultrasound Guided Regional Injections for Emergency Room Doctors-

https://painexam.com/events/us_guided_pain_for_emergency_medicine_physicians/

Podcast Resources:
https://www.spineintervention.org/news/548668/Preliminary-Recommendations-on-Corticosteroid-Injections-and-COVID-19-Vaccinations.htm

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New Updates-

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Dr. Rosenblum Interviews Amitabh Gulati, MD- WAPMU Faculty

Dr. Rosenblum sits down with Amitabh Gulati, MD
WAPMU Faculty, to Discuss Cancer Pain Topics.

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Upcoming Ultrasound Training Workshop Event Schedule-

March 14, 2021-
Ultrasound Guided Regional Anesthesia for Anesthesiologists-
https://painexam.com/events/march-14-2020-anesthesiology-ultrasound-course-regional-anesthesia-acute-pain/

April 18, 2021-
Live Ultrasound Training in NYC for Pain and Regional Anesthesia-
https://painexam.com/events/in-person-live-ultrasound-training-april-18-nyc/

May 16th, 2021-
Advanced Ultrasound Guided Regional Injections for Emergency Room Doctors-
https://painexam.com/events/us_guided_pain_for_emergency_medicine_physicians/

Resources:
About Amitabh Gulati, MD-
https://www.mskcc.org/cancer-care/doctors/amitabh-gulati#about-me

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Ginger and Muscle Pain? Dr. Rosenblum Discusses the Effects of Ginger on Muscle Pain and Updates on the Upcoming Ultrasound Training Workshops: Ultrasound Training Event Schedule-

February 28, 2021-
Ultrasound Guided Pain Procedures in the Pain Office
https://painexam.com/events/ultrasound-guided-interventional-pain-and-regional-anesthesia-virtual-training/

March 14, 2021-
Ultrasound Guided Regional Anesthesia for Anesthesiologists
https://painexam.com/events/march-14-2020-anesthesiology-ultrasound-course-regional-anesthesia-acute-pain/

April 18, 2021-
Live Ultrasound Training in NYC for Pain and Regional Anesthesia
https://painexam.com/events/in-person-live-ultrasound-training-april-18-nyc/

Podcast Resources:

Köhne JL, Ormsbee MJ, McKune AJ. Supplementation Strategies to Reduce Muscle Damage and Improve Recovery Following Exercise in Females: A Systematic Review. Sports (Basel). 2016 Nov 11;4(4):51. doi: 10.3390/sports4040051. PMID: 29910299; PMCID: PMC5968901.

Wilson PB. Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic Review. J Strength Cond Res. 2015 Oct;29(10):2980-95. doi: 10.1519/JSC.0000000000001098. PMID: 26200194.

Black CD, Herring MP, Hurley DJ, O'Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain. 2010 Sep;11(9):894-903. doi: 10.1016/j.jpain.2009.12.013. Epub 2010 Apr 24. PMID: 20418184.

Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med. 2011 Dec;12(12):1808-18. doi: 10.1111/j.1526-4637.2011.01261.x. Epub 2011 Nov 4. PMID: 22054010.

Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9. doi: 10.1016/j.joca.2009.10.002. Epub 2009 Oct 8. PMID: 19836480.

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See you in Miami at ASPN this July....

Dr. Rosenblum sits down with Tim Deer and discusses work life balance, neuromodulation, pain management training, the American Society of Pain and Neuroscience...

Next Ultrasound Course for Pain Docs:

Virtual: February 28th

In Person: April 18th in NYC

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Annual ASPN Conference link:

https://aspnpain.com/annual-conference-2021/   March Madness Debate link (we’ll continue to update the page as more information becomes available): https://aspnpain.com/aspn-march-madness-debates/   The Superbowl of Debates link: https://aspnpain.com/aspn-the-superbowl-of-debates/   If desired, the 2021 Call for Poster Abstracts link: https://aspnpain.com/aspn-call-for-poster-abstracts/

Interscalene Block, Piriformis Trigger Point, & Propofol in the ED?

In preparation for this weekend's:

Ultrasound Pain Course for Emergency Medicine Physicians,

Dr. Rosenblum discusses two recent articles in the literature discussing Interscalene Brachial Plexus Blocks vs Propofol for anterior shoulder dislocation and Piriformis injections...

EM Physicians:  Opt in for the Emergency Room Ultrasound Pain Newsletter for Course Calendar!

Pain Physicians! Subscribe for US Course Schedule, Calendar & Discounts! * indicates required Email Address * First Name Last Name      

Course Schedule- Winter 2021 Released- Join our newsletter for updates!

Upcoming  Ultrasound Course Dates for Emergency Medicine Physicians, Anesthesiologists and Pain Physicians Learn Brachial Plexus, Femoral, Sciatic, Saphenous, Genicular, IPACK, TAP, Paravertebral, Inercostal, Sacroiliac, Peripheral nerves, Iliioinguinal, Cluneal nerve blocks and more! February 7, 2020
Ultrasound Guided Pain Procedures for Emergency Room Physicians

February 28, 2020
Ultrasound Guided Pain Procedures in the Pain Office

March 14, 2020
Ultrasound Guided Regional Anesthesia for Anesthesiologists   Podcast References:
1.  Ultrasound-guided interscalene nerve block vs procedural sedation by propofol and fentanyl for anterior shoulder dislocations. Author links open overlay pane lEsmaeilRaeyat DoostaMohammad MehdiHeiranbMitraMovahedicAmirhosseinMirafzalchttps://www.sciencedirect.com/science/article/abs/pii/S0735675717302966#!   2- Ultrasound‐guided trigger point injection for piriformis syndrome in the emergency department Victor M. Aquino‐Jose MD Veronika Blinder MD Jennifer Johnson BA Tatiana Havryliuk MD Journal of the American College of Emergency Physicians Open Volume 1, Issue 5

Dr. Rosenblum interviews Dr. Baxter on her thermo-mechanical neuro-modulatory pain relief platform.

Amy Baxter MD FAAP FACEP is a Clinical Associate Professor in Emergency Medicine at Augusta University and the founder and CEO of Pain Care Labs, the industry leader in noninvasive pain relief solutions. She is an academic, physician and research focused entrepreneur that invented a thermo-mechanical neuro-modulatory pain relief platform. Her patents include VibraCool® Vibrational Cryotherapy to treat tendinopathies and decrease opioid use, and her disruptive Buzzy® device, which has been used to control needle pain for over 37 million needle procedures. Dr. Baxter was awarded over 2.8MM in Fast-Track SBIRs by the NIH.

She also prepared and filed the FDA 510K submission for medical devices, securing the FDA expansion of the utilization to include muscle pain and cosmetic injection pain control. Dr. Baxter and Pain Care Labs were recently honored with the 2020 Tibbetts Award for Innovation for the substantial economic and social benefits the company’s pain-relieving medical devices have contributed to the United States. 

Buzzy for Healthcare, https://shop.paincarelabs.com/collections/healthcare

Buzzy for personal, https://shop.paincarelabs.com/collections/buzzy%C2%AE

VibraCool, https://shop.paincarelabs.com/collections/vibracool-r

Ultrasound Guided Interventional Pain Training

 

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Dr. Rosenblum preempts his upcoming Ultrasound Guided Interventional Pain Course for Emergency Medicine Physicians on February 7, 2021 with a Journal club describing the Erector Spinae Plane Block.   https://painexam.com/ultrasound-guided-regional-anesthesia-pain-management-regenerative-medicine/ Subscribe for US Course Schedule, Calendar & Discounts! * indicates required Email Address * First Name Last Name     February 7, 2020
Ultrasound Guided Pain Procedures for Emergency Room Physicians

February 28, 2020
Ultrasound Guided Pain Procedures in the Pain Office

March 14, 2020
Ultrasound Guided Regional Anesthesia for  Anesthesiologists Find out More! Private Session
Register on Link (for any day)- Set Day and Time Separately with Dr. Rosenblum Sign Up and Schedule a Private Session

• 4 Hour CME Webinar Access
• 2 Hour Hands on (in Person in NY or via Zoom)
• Tips on Safe Integration into your Practice
• Billing

Register Now!         Reference  

1. Krishnan S, Cascella M. Erector Spinae Plane Block. [Updated 2020 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545305/

2. EnesAydinbEmreSengunaAtifBayramogluaHaci AhmetAlicibHigh-thoracic ultrasound-guided erector spinae plane block for acute herpes zoster pain management in emergency department. The American Journal of Emergency Medicine. Volume 37, Issue 2, February 2019, Pages 375.e1-375.e3ErdalTekinaAliAhiskalioglubMuhammed 

    

Dr. Rosenblum interviews SmartAppt Creator, Albert Pilip, MD on his Doctor-Patient Friendly App that takes the Pain out of Scheduling Appointments.

Sign up to my latest affiliates answer to Zocdoc

Ultrasound Course Schedule- Winter 2021 Released- Join our newsletter for updates!

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  https://painexam.com/product/private-ultrasound-instruction-for-regional-anesthesia-pain-management/Private Session
Register on Link (for any day)- Set Day and Time Separately with Dr. Rosenblum Sign Up and Schedule a Private Session

• 4 Hour CME Webinar Access
• 2 Hour Hands on (in Person in NY or via Zoom)
• Tips on Safe Integration into your Practice
• Billing

Upcoming  Ultrasound Course Dates for Emergency Medicine Physicians, Anesthesiologists and Pain Physicians

Learn Brachial Plexus, Femoral, Sciatic, Saphenous, Genicular, IPACK, TAP, Paravertebral, Inercostal, Sacroiliac, Peripheral nerves, Iliioinguinal, Cluneal nerve blocks and more!

February 7, 2020
Ultrasound Guided Pain Procedures for Emergency Room Physicians

February 28, 2020
Ultrasound Guided Pain Procedures in the Pain Office

March 14, 2020
Ultrasound Guided Regional Anesthesia for  Anesthesiologists Register Now!

Dr. Rosenblum apologizes on behalf of the Pain Physicians for 2 overlooked topics that could help pain patients...

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References

Nutritionalfacts.org

Mendonça CR, Noll M, Castro MCR, Silveira EA. Effects of Nutritional Interventions in the Control of Musculoskeletal Pain: An Integrative Review. Nutrients. 2020 Oct 9;12(10):3075. doi: 10.3390/nu12103075. PMID: 33050122; PMCID: PMC7601187.

Dr. Rosenblum interviews Pain Physician, Dr. Sidharth Verma on his initiative the Mumbai Pain School and discusses the next 

fb.me/MumbaiPainSchool
instagr.am/MumbaiPainSchool
twitter.com/MumbaiPain

Upcoming  Ultrasound Course Dates for Emergency Medicine Physicians, Anesthesiologists and Pain Physicians Learn Brachial Plexus, Femoral, Sciatic, Saphenous, Genicular, IPACK, TAP, Paravertebral, Inercostal, Sacroiliac, Peripheral nerves, Iliioinguinal, Cluneal nerve blocks and more! February 7, 2020
Ultrasound Guided Pain Procedures for Emergency Room Physicians

February 28, 2020
Ultrasound Guided Pain Procedures in the Pain Office

March 14, 2020
Ultrasound Guided Regional Anesthesia for  Anesthesiologists

 

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Exploring the Efficacy of Autologous Platelet Leukocyte Rich Plasma Injections in Chronic Low Back Pain & Understanding Degenerative Lumbar Spinal Stenosis

 Host David Rosenblum, MD

 Episode Date: October 25, 2024

In this episode, Dr. David Rosenblum discusses two significant studies related to chronic low back pain and degenerative lumbar conditions. The first study focuses on the use of autologous platelet leukocyte rich plasma (PLRP) injections for treating atrophied lumbar multifidus muscles, while the second study investigates the correlation between muscle atrophy and the severity of degenerative lumbar spinal stenosis (DLSS).

 Featured Article 1: 
- Effect of Autologous Platelet Leukocyte Rich Plasma Injections on Atrophied Lumbar Multifidus Muscle in Low Back Pain Patients with Monosegmental Degenerative Disc Disease
- **Authors:** Mohamed Hussein, Tamer Hussein
 

 Key Points Discussed 
1. Background:  Correlation between lumbar multifidus muscle dysfunction and chronic low back pain.
2.  Study Overview: 115 patients treated with weekly PLRP injections for six weeks, followed for 24 months.
3.  Outcome Measures:  Significant improvements in NRS and ODI scores, with high patient satisfaction.
4. Conclusions: PLRP injections into the atrophied multifidus muscle are safe and effective for managing chronic low back pain.

 Featured Article 2: 
-   Degenerative Lumbar Spinal Stenosis
 Authors:*  Gen Xia, Xueru Li, Yanbing Shang, Bin Fu, Feng Jiang, Huan Liu, Yongdong Qiao

 Key Points Discussed 
1. Background:  DLSS is a common condition in older adults, often leading to muscle atrophy and disability.
2. Study Overview: A retrospective analysis involving 232 patients to investigate the correlation between muscle atrophy and spinal stenosis severity.
3.  Results: 
   - Significant differences in the ratio of fat-free multifidus muscle cross-sectional area between stenotic and non-stenotic segments.
   - A strong positive correlation was found between multifidus atrophy and the severity of spinal stenosis.
   - The atrophy was more pronounced on symptomatic sides of the spine compared to contralateral sides.
4.  Conclusions:  The findings suggest that more severe spinal stenosis is associated with greater muscle atrophy, emphasizing the importance of addressing muscle health in DLSS patients.

 Discussion: 
Dr. Rosenblum provides insights into how these studies inform clinical practices for treating chronic low back pain and managing degenerative conditions. He emphasizes the need for comprehensive treatment strategies that consider both muscle health and spinal integrity which may be achieved via peripheral nerve stimulation of the medial branch nerve and multifidus muscle or PRP injection in to the multifidus muscle.

 Closing Remarks: 
Listeners are encouraged to stay informed about innovative treatment options and the importance of muscle assessment in managing spinal disorders.

 

**Follow Us:**
- Subscribe to the Painexam Podcast for more episodes discussing the latest in pain management research and treatments.
- Connect with us on social media [insert social media links].

NRAP Academy also offers:

• Board Review
• Anesthesiology
• Pain Management
• Physical Medicine and Rehabilitation
• Regenerative Medicine Training 
• Live Workshops
• Online Training
• The Virtual Pain Fellowship (online training program with discount to live workshops)

 

 

 

 

Regional Anesthesia & Pain Ultrasound Course

 

Private Training Available

Email Info@NRAPpain.org

**Disclaimer:** The information presented in this podcast is for educational purposes only and should not be considered medical advice. Always consult a healthcare professional for medical concerns.

References

Xia, G., Li, X., Shang, Y. et al. Correlation between severity of spinal stenosis and multifidus atrophy in degenerative lumbar spinal stenosis. BMC Musculoskelet Disord 22, 536 (2021). https://doi.org/10.1186/s12891-021-04411-5

Hussein M, Hussein T. Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. SICOT J. 2016 Mar 22;2:12. doi: 10.1051/sicotj/2016002. PMID: 27163101; PMCID: PMC4849261.

Is PRP Cost Effective? If So, At What Price?

Discussed in this episode:
-Talking to patients about PRP and Biologics
-Is PRP better?
-Dr. Rosenblum’s management of his own knee pain
-Ultrasound Training

Live Virtual Ultrasound CME Training Event Set for Dec. 6th, 2020

Click here to register now! https://painexam.com/events/

Podcast References:
Bendich, I, et al. What Is the Appropriate Price for Platelet-Rich Plasma Injections for Knee Osteoarthritis? A Cost-Effectiveness Analysis Based on Evidence From Level I Randomized Controlled Trial The Journal of Arthroscopic an Related Surgery. VOLUME 36, ISSUE 7, P1983-1991.E1, JULY 01, 2020

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• https://www.youtube.com/user/DocRosenblum/videos

  http://www.RSDS.org               www.RSDS.org   On this Episode Dr.  Rosenblum: ·         Interviews Jim Broatch, Executive VP and Director: jwbroatch@rsds.org and Beth Seickel bseickel45@gmail.com of the RSDSA ·         Discuss how the Reflex Sympathetic Dystrophy Syndrome Association is making a difference in the lives of Patients and Families affected by CRPS ·         NonProfit activities that the RSDSA has developed ·         Clinician Education and more! RSDSA Courses Below https://rsds.org/accredited-course-on-crps-for-mds-and-rns/https://rsds.org/accredited-course-on-crps-for-mds-and-rns/   https://rsds.org/rsdsa-pediatric-crps-accredited-online-course/ w Log in and enter RSDSA as your cause! They will make a donation to RSDSA!  Thank you for your support.   http://rsds.org/donate/ Other links which may be helpful   http://rsds.org/youve-been-diagnosed-with-crpsrsd-now-what/   http://rsds.org/joinmembership/ https://rsds.org/how-to-obtain-the-best-medical-care-for-crps/ https://rsds.org/understanding-crps-pain/ https://rsds.org/how-crps-is-diagnosed/

Is Local Anesthetic in Cervical Epidurals Beneficial?

In this podcast episode:
Dr. Rosenblum announces postponement of November 22 Ultrasound Course.

• Discusses RAPM article on Lidocaine in the Cervical Epidural Space
• Benefits of Ultrasound for Guiding injections to treat Cervical Radiculopathy
• Pitfalls of the Standard of Care

Private Consultation Service and Chart Review Available for Pain Patients- Inquire at DRosenblum@RMCPain.com

Live Virtual Ultrasound CME Training Event Set for Dec. 6th, 2020

Click here to register now! https://painexam.com/events/ultrasound-guided-interventional-pain-and-regional-anesthesia-virtual-training/

Podcast References:
McCormick ZL, Burnham T, Cunningham S, et al
Effect of low-dose lidocaine on objective upper extremity strength and immediate pain relief following cervical interlaminar epidural injections: a double-blinded randomized controlled trial
Regional Anesthesia & Pain Medicine Published Online First: 11 August 2020. doi: 10.1136/rapm-2020-101598

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https://www.youtube.com/user/DocRosenblum/videos

Autism and Labor Epidurals?

Dr. Rosenblum discusses JAMA’s October 2020 article that suggests an association between Labor Epidural and the diagnosis of Autism Spectrum Disorder

• Summary of the study
• Responses from other physicians
• Statements by the The Society for Obstetric Anesthesia and Perinatology (SOAP), the American Society of Anesthesiologists (ASA), the Society for Pediatric Anesthesia (SPA), the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM)

Speaking of Labor Analgesia... Learn TAP Blocks, Ilioinguianl Block and more!

Next Ultrasound Guided Regional Anesthesia and Interventional Pain Courses..

November 22, 2020 - Live In Person Ultrasound Training-

"In-Person" Ultrasound Guided Pain Management 7 CME Credit Training Event Nov. 22nd, 2020. Limited Spaces!

Covering:
-Upper Extremity (Brachial Plexus, Axillary, Suprascapular)
-Lower Extremity (Femoral, Sciatic, Popliteal, Ankle, IPACK, Genicular)
-Soft Tissue & Joint (Shoulder, ITB, Hip, Knee, Plantar Fascia)
-Peripheral Nerve Blocks and Spine (Ilioinguinal, TAP, Intercostal, -Paravertebral, Caudal, Cervical , Cluneal and much more!)
-Live Model Scanning and Practice with Phantoms

Register Now!

https://painexam.com/events/in-person-live-ultrasound-training-november-22-nyc/

December 6, 2020-  Virtual Interventional Pain and Regional Anesthesia Training Webinar-

New Ultrasound Guided Interventional Pain Management & Regional Anesthesia 4 CME Webinar Event by PainExam, Set for Dec. 6th, 2020

Covering:

Ultrasound Guided Interventional Pain Virtual Training on Nerve Blocks, Soft Tissue Injections, Spine, etc.
-Upper extremity (Brachial Plexus, Axillary, Suprascapular, Radial, Ulna, Median)
-Lower Extremity (Femoral, Sciatic, Popliteal, Genicular, IPACK, Ankle)
-Soft Tissue and Joint (Knee & Shoulder)
-Peripheral Nerve Block (Occipital, TAP, Ilioinguinal, Intercostal Paravertebral
-Spine (Sacroiliac, Caudal, Cervical Selective Nerve Root, Medial Branch)

Register Now!
https://painexam.com/events/ultrasound-guided-interventional-pain-and-regional-anesthesia-virtual-training/

Podcast References:

https://www.asahq.org/about-asa/newsroom/news-releases/2020/10/labor-epidurals-and-autism-joint-statement

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2771634

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Myths in Pain Medicine: Steroid Doses, Spine Surgery, Vasectomies, etc.

Dr. Rosenblum discusses a recent email (below) from a patient suffering from Post Vasectomy Pain who reached out after hearing the recent PVPS Episode of the PainExam Podcast.

Also Discussed:
- Myth of 3 Steroid Shots Per Year
- Myth of Needing Cervical Spine Surgery to Avoid Paralysis if Rear Ended
- Myth of Downplaying Surgeries like Vasectomies (See Below)

"Dr. Rosenblum

I appreciated your recent podcast on Post Vasectomy Pain Syndrome. This is a condition I am currently suffering from. I am being treated by a pelvic floor physical therapist, which is improving muscular coordination, but not improving the pain much.

My vasectomy was in December, 2017 and I have been in pain since then. It was very distracting for about 10 months, and I had a 2 month course of Lyrica which helped reduce the pain. After about October 2018 the pain went down but it is always there. Ejacuation is not pleasurable, rather it feels like someone is squeezing my testicles unpleasantly and afterward I have a dull ache or burning sensation which persists for about 1-2 days.

I thought your reactions and impressions on reviewing the medical consequences of vasectomy to be amusing. The surgery is typically presented as being as trivial as excising a wart. This may be the experience of 90% of men, but if you end up with chronic complications, it is no exaggeration to say that it is capable of ruining your life. I am convinced that this is more common and causes far more suffering that is generally understood, affecting probably 1-2% of men who get a vasectomy. Men tend to suffer in silence. Urologists tend to resist attributing the problems to the vasectomy.

I have collected several thousand links to stories that men have posted over the last few decades, describing this unfortunate disease. I would encourage you to take a look at the ones I have posted here:

https://www.reddit.com/r/postvasectomypain/wiki/timeline

There are over 720 stories that I have posted, linked to the original source, and indexed chronologically, along with story codes. I have made it my unhealthy hobby to create the best reference possible for understanding what men go through when they end up with PVPS. I post a new story every morning and have enough to keep going for many years.

The best online forum for PVPS is www.postvasectomypain.org

Good luck with your patient"

Live "In-Person" Ultrasound Guided Injection 7 CME Training Event in NYC! Nov. 22nd, 2020

Limited Seating, Register Here! https://painexam.com/events/in-person-live-ultrasound-training-november-22-nyc/

Live "Virtual" Ultrasound Guided Pain Management Injection 4 CME Training Event- Dec. 6th, 2020

Register Here! https://painexam.com/events/ultrasound-guided-interventional-pain-and-regional-anesthesia-virtual-training/

Podcast References:
https://cdn.ymaws.com/www.spineintervention.org/resource/resmgr/factfinder/FactFinder_2019_06_Annual_Do.pdf

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Podcast Episode Sponsor-

Post Vasectomy Pain Syndrome:

Dr. Rosenblum reviews Post Vasectomy Pain Syndrome
When Urology cannot help, he ponders:

Ultrasound Guided Genito Femoral Nerve Block

• Ganglion impar
• PRP Injection
• Peripheral Nerve Stimulation
• DRG Stimulation

For Ultrasound Training online go to PainExam.com/Events
For Private in person training, email Dr. Rosenblum at DRosenblum@RMCPain.com or...

"LIVE" In-Person Ultrasound Training Event in NYC Nov. 22nd!

For more information about the Live In-Person Ultrasound CME Training Event, please visit:

https://painexam.com/events/in-person-live-ultrasound-training-november-22-nyc/

Dec. 6 "LIVE" Ultrasound Training CME Webinar Event-

For more information about the Live Ultrasound Training CME Webinar Event, please visit:

https://painexam.com/events/ultrasound-guided-interventional-pain-and-regional-anesthesia-virtual-training/

Check Out Dr. Rosenblum in the recent Clarius Webinar!

Click here to Watch Now!

 

Podcast References:

http://vasectomy-lib.s3.amazonaws.com/BJU%20International%202008%20Tandon.pdf

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Consensus Statement on Facet Joints Reviewed!

Dr. Rosenblum Discusses the recent Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group released earlier this year.

Also discussing:

FREE Ultrasound Webinar with Clarius on Wednesday October 28th,

https://clarius.com/webinar/bullseye-why-ultrasound-is-now-the-standard-for-guiding-injections/

NEW COMPREHENSIVE ULTRASOUND COURSE FOR PAIN MANAGEMENT AND REGIONAL ANESTHESIA- Dec. 6th!

Podcast reference:

Cohen SP, Bhaskar A, Bhatia A, et al Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group Regional Anesthesia & Pain Medicine Published Online First: 03 April 2020. doi: 10.1136/rapm-2019-101243

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Peng Blocks   On this Podcast episode Doctor Rosenblum discusses the Pericapsular Nerve Group Block as An Excellent Option for Analgesia for Positional Pain in Hip Fractures...   Dr. Rosenblum is proud to announce joining the WAPMU Faculty!
  In addition, Dr. Rosenblum is offering a 30% discount on Sunday October 18, 2020’s Ultrasound webinar  to those who listen to the podcast.   Register at PainExam.com/Events   SoMeDocs Guest Appearance! Join tomorrow at 10:30 AM! Dr. Rosenblum will appear on SoMeDocs discussing Consulting as a Medical Professional. https://www.facebook.com/groups/somedocs/permalink/953862511690182 Subscribe to our mailing list * indicates required Email Address *       References- Utsav Acharya, Ritesh Lamsal, "Pericapsular Nerve Group Block: An Excellent Option for Analgesia for Positional Pain in Hip Fractures", Case Reports in Anesthesiology, vol. 2020, Article ID 1830136, 3 pages, 2020. https://doi.org/10.1155/2020/1830136

COVID-19 and Pain Management

Dr Rosenblum discusses Medications and Immune Response. Considerations for pain patients at risk for COVID-19.

Dr. Rosenblum also discusses Peripheral Nerve Stimulation in a patient with a Spinal Cord Stimulator...

New Ultrasound Pain Management CME Webinar Event Hosted by PainExam, Set for October 18, 2020!

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References-
Puntillo F, Giglio M, Brienza N, et al. Impact of COVID-19 pandemic on chronic pain management: Looking for the best way to deliver care. Best Pract Res Clin Anaesthesiol. 2020;34(3):529-537. doi:10.1016/j.bpa.2020.07.001

About PainExam-

Online Pain Management Board Review for the ABA, ABPM, ASIPP and WIP FIPP MOCA and primary certification in pain management. 40 CME credits available for participation
https://www.painexam.com

Dr. Rosenblum Discusses:

• Sickle Cell Disease
• Crisis
• Types of Pain associated with Sickle Cell Disease
• Opiate and non opiate management

 

Subscribe to our mailing list * indicates required Email Address *       References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294061/

Dr. Rosenblum reviews the benefits of Scrambler Therapy for CRPS and Neuropathic Pain State. 

• What is Scrambler Therapy?
• Efficacy of Scrambler Therapy for Neuropathic Pain 
• Mechanism of action of Scrambler Therapy
• Regenerative Pain Management Course
• PainExam Board Prep
• NRAP Academy Private Tutorials for Ultrasound Guidance and Regenerative Medicine

ST was introduced as a chronic pain relief method in 2003. That same year, Giuseppe Marineo published findings from a small clinical trial involving 11 terminal cancer patients suffering from drug-resistant chronic visceral pain, with all participants showing positive responses and significant reductions in pain scores. In a subsequent trial involving 226 patients with neuropathic pain, 80% reported a 50% reduction in pain. Since then, numerous case reports and studies have documented the use of ST for various pain types.

Evidence from these reports suggests that ST is effective for managing both acute and chronic pain from different causes. For instance, a child with acute mixed pain, resistant to pharmacological treatment, experienced significant relief after four ST sessions, with pain levels dropping from 5/10 to 0/10. Additionally, a 52-year-old woman with burning pain from her foot to knee, stemming from a right medullary acute hemorrhage and suffering for 12 years, reported immediate relief after ST. Her pain score decreased from 9/10 to 3/10 on the first day, and to 0/10 by the second day, remaining below 1 on the Visual Analog Scale (VAS) throughout the 10-day treatment period.

In terms of chronic pain, literature includes a case where a patient with shoulder joint pain and limited range of motion saw significant pain reduction and increased mobility after 10 sessions of ST. ST has shown considerable promise in treating severe pain conditions that are typically difficult to manage, such as complex regional pain syndrome and pain related to HIV.

Despite the encouraging results from these case studies, higher-quality evidence is necessary to establish the efficacy of ST, which could be obtained through extensive clinical trials, particularly focusing on chronic pain. Besides the aforementioned studies by Marineo and Sabato et al, additional trials have indicated that ST is an effective treatment for various chronic pain conditions, including low back pain, postherpetic pain, and neuropathic pain. For instance, a prospective study on chronic low back pain patients showed a significant decrease in VAS scores from 8.12 to 3.63 after six treatment days. Another trial involving 10 patients with postherpetic pain reported a drop in the average Numeric Rating Scale (NRS-11) score from 7.64 to 1.46 at baseline and 0.42 to 0.89 after one month, with benefits persisting at two and three months.

ST has also demonstrated significant potential in treating neuropathic pain. In a prospective study of 45 patients with neuropathic pain lasting over three months, 28 experienced a decrease in Douleur Neuropathique en 4 questions (DN4) pain scores, with four patients stopping treatment early due to complete pain resolution. The mean baseline DN4 score dropped from 5.67 to 2.82 by the end of treatment. A pilot randomized trial involving 52 patients found that 21 out of 26 in the intervention group achieved complete pain relief.

While the findings from these studies, along with others that have been systematically analyzed, suggest strong evidence for the efficacy of ST, a definitive conclusion regarding its effectiveness has not yet been reached. A systematic review by Majithia et al concluded that while studies generally indicate ST results in pain reduction with lasting benefits, there are still gaps in the evidence.

This article aims to evaluate the research needs surrounding ST for cancer pain management. While Majithia et al focused on chronic pain across various conditions and noted specific evidence limitations, this study will concentrate on the effectiveness of ST for cancer-related pain. The objective is to identify gaps in the existing literature and provide recommendations for future research through a systematic review. We will specifically analyze the types and levels of evidence supporting the use of ST in managing cancer pain and determine what studies are necessary to enhance the evidence base.

References 

Majithia, N., Smith, T.J., Coyne, P.J. et al. Scrambler Therapy for the management of chronic pain. Support Care Cancer 24, 2807–2814 (2016). https://doi.org/10.1007/s00520-016-3177-3

Mohamed, Mohamed S. I.1; Alkahlout, Lama1; Elgamal, Salma1; Mohiuddin, Amna1; Al-sayed, Talal1; Al-Marri, Hamad1; Zahid, Fatima1; Martínez-Magallanes, Daniela2; Fregni, Felipe2; Doi, Suhail A. R.1; Abdallah, Abdallah M.3; Musa, Omran A.H.1,4; Khan, Muhammad Naseem1; Babu, Giridhara R.1,*. Efficacy of scrambler therapy in chronic neuropathic pain: pairwise and dose-response meta-analysis. Brain Network and Modulation 3(3):p 63-70, Jul–Sep 2024. | DOI: 10.4103/BNM.BNM_20_24

Kashyap, Komal, and Sushma Bhatnagar. "Evidence for the efficacy of scrambler therapy for cancer pain: a systematic review." Pain Physician 23.4 (2020): 349.

Dr. Rosenblum ponders the value of Anecdotal Medicine and Questions the so called 'Standard of Care'

For More Educational Content and Course Go to PainExam.com/Events

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References

Moffett P, Moore G. The standard of care: legal history and definitions: the bad and good news. West J Emerg Med. 2011;12(1):109-112.

  https://sciencebasedmedicine.org/the-role-of-anecdotes-in-science-based-medicine/

Dr. Rosenblum explores the issue of Post COVID Pain Syndrome!
Is it a real thing or just secondary to prolonged inactivity, anxiety and isolation?

New Ultrasound Guided Interventional Pain Course
SUNDAY OCTOBER 18, 10-2PM!

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REFERENCES

Kemp HI, Corner E, Colvin LA. Chronic pain after COVID-19: implications for rehabilitation [published online ahead of print, 2020 May 31]. Br J Anaesth. 2020;S0007-0912(20)30403-7. doi:10.1016/j.bja.2020.05.021

  https://jamanetwork.com/journals/jama/fullarticle/2768351

 Dr. Rosenblum Interviews Panamanian Pain Physician In Spanish
(en Espanol)

Subtitles on the PainExam Youtube Channel or PainExam.com/news page

David Rosenblum, MD welcomes Justin Harvey, Anesthsia Success Podcast Host and Financial Planner to discuss

Investing
Loans
Diversification
Gold
Fiduciary 
Wealth Management 
COVID and so much more!

David Rosenblum, MD is a Brooklyn and Great Neck Pain Physician at AABP Integrative Pain Care.  For a Telehealth or In Person appointment, go to AABPPain.com or call

Brooklyn     718 436 7246

Great Neck 516 482 7246

Announcement!

https://zoom.us/webinar/register/WN_4tmYVwb8TeWKtjvfMqk3fw

 

Links to Alaa's Anesthsiolgy and Pain Medicine Books   https://www.amazon.com/s?i=digital-text&rh=p_27%3AAlaa+Abd-Elsayed&s=relevancerank&text=Alaa+Abd-Elsayed&ref=dp_byline_sr_ebooks_1 Amazon.com: Alaa Abd-Elsayed: Kindle Store Online shopping from a great selection at Kindle Store Store. www.amazon.com

 

https://pubmed.ncbi.nlm.nih.gov/?term=abd-elsayed   https://www.uwhealth.org/findadoctor/profile/alaa-a-abd-elsayed-md-mph/9646   https://www.anesthesia.wisc.edu/index.php?title=Abd-Elsayed_Laboratory Abd-Elsayed Laboratory - UWSMPH - Department of Anesthesiology Our research is focused on finding new clinical strategies to reduce chronic pain and for general pain management treatment. By carefully considering the pathology of the pain and treating the whole patient, we have been able to treat many patients with state-of-the-art therapies, including using advanced technology and modalities, that are successful in reducing or blocking pain and ... www.anesthesia.wisc.edu    

https://painexam.com/preparation-for-the-pain-boards/

Dr Rosenblum takes a section of his Preparation for the Pain Boards Lecture, given during the ASIPP Board Review Course and gives an informative talk describing the importance of Board Certification in Pain Management, preparation, keywords and  the differences in Pass rates of the ABA, ABPM  and ABIPP.  The discussion is a prelude to upcoming high yield keyword based webinars for the pain boards.

For more info subscribe to the PainExam Newsletter!

 

 

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Dr. Rosenblum discusses a recent consensus guideline on Low Platelets in the Obstetric Patient. 

• Low Platelets and Epidurals in the OB Patient
• ASIPP Board Review Course
• Painexam Alumni Emails
• Congratulations to Graduates!
• Welcome incoming Residents and Pain Fellows!

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Justin Harvey, host of the Anesthesia Success podcast interviews Dr. Rosenblum for his podcast.  Discussed in this podcast:

• Business of Medicine
• Industry Affiliation
• Preparation for COVID
• The Definition of Success

Podcast: www.anesthesiasuccess.com Youtube channel: https://www.youtube.com/channel/UCf-ooT3l5PR6tV5GaQe7NhA Linkedin: https://www.linkedin.com/in/justin-harvey-46625516/ Financial planning: www.apm-wealth.com

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ACGME Accredited Pain Fellowship or not, this is a can't miss episode reviewing the ABIPP Exam and other opportunities available to not only learn pain medicine, but to learn the business and politics of this amazing specialty.

 

Click Below to Preview our Newest Course

 

Click Below to Preview our Newest Course

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PainExam Podcast Episode: An In-Depth Look at Hydrogen-Rich Water for Chronic Inflammatory Pain

In a recent episode of the PainExam podcast, Dr. David Rosenblum delves into an intriguing study published in the journal Antioxidants, exploring the therapeutic potential of hydrogen-rich water (HRW) in alleviating chronic inflammatory pain and associated mood disorders in mice. The study, conducted by Santiago Coral-Pérez and colleagues from the Institut d’Investigació Biomèdica Sant Pau and Universitat Autònoma de Barcelona, presents compelling evidence supporting the analgesic, antidepressant, and anxiolytic effects of HRW.

Study Overview

The study investigates the efficacy of HRW in treating nociceptive responses and affective disorders associated with chronic inflammatory pain. Using a mouse model induced by the subplantar injection of complete Freund's adjuvant (CFA), the researchers evaluated the impact of HRW on several parameters:

1. Nociceptive Responses: Mechanical allodynia and thermal hyperalgesia.
2. Affective Disorders: Depressive-like behaviors (measured by Tail Suspension Test and Forced Swimming Test) and anxiety-like behaviors (assessed using Elevated Plus Maze and Open Field tests).
3. Biomarker Analysis: Levels of oxidative stress, inflammatory, and apoptotic markers in the paws and amygdala.

Key Findings

1. Analgesic Effects:

• Mechanical Allodynia and Thermal Hyperalgesia: The study found that both intraperitoneal and subplantar administration of HRW significantly reduced mechanical allodynia and thermal hyperalgesia in CFA-injected mice. Remarkably, the local (subplantar) administration showed greater effectiveness, achieving complete inhibition of nociceptive responses with just one day of treatment.

2. Antidepressant and Anxiolytic Effects:

• Depressive-like Behaviors: HRW treatment normalized the increased immobility times in both the Tail Suspension Test and Forced Swimming Test, indicating potent antidepressant properties.
• Anxiety-like Behaviors: HRW also reversed the anxiety-like behaviors in the Elevated Plus Maze and Open Field tests, showcasing its anxiolytic effects without impairing motor function.

3. Biochemical Pathways:

• The study highlighted the significant role of the Nrf2/HO-1-NQO1 pathway in mediating the analgesic effects of HRW. Inhibitors targeting this pathway reversed the pain-relieving actions of HRW, underscoring its pivotal role.
• Oxidative Stress and Inflammation: HRW treatment reduced the expression of oxidative (4-HNE), inflammatory (p-IKBα), and apoptotic (BAX) markers in both the paw and amygdala tissues, demonstrating its broad-spectrum protective effects.

Implications for Clinical Practice

Dr. Rosenblum emphasizes the potential of HRW as a novel therapeutic strategy for chronic inflammatory pain and its associated comorbidities. The study's findings suggest that HRW could offer a multifaceted approach, addressing both pain and mood disorders through its antioxidant, anti-inflammatory, and anti-apoptotic properties.

Conclusion

The episode concludes with a discussion on the broader implications of these findings for pain management, particularly in conditions where chronic inflammatory pain is prevalent. Dr. Rosenblum highlights the need for further clinical trials to validate these promising preclinical results and explore the potential of HRW in human subjects.

For more detailed insights into this study, including potential applications and future research directions, tune into the PainExam podcast with Dr. David Rosenblum.

For more information go to:

https://molecularhydrogeninstitute.org/links-mhi/

Other Announcements from NRAP Academy:

• PainExam App is ready for iphone
•  
  •  Pain Management Board Prep migrated to NRAPpain.org
• AnesthesiaExam Board Prep migrated to NRAPpain.org
• PMRExam Board Prep migrated to NRAPpain.org

https://www.nrappain.org/bundles/Virtual-Pain-Fellowship   Live Workshop Calendar

 

 

  Ultrasound Interventional Pain Course Registration    For Anesthesia Board Prep Click Here!

References

Coral-Pérez, S., Martínez-Martel, I., Martínez-Serrat, M., Batallé, G., Bai, X., Leite-Panissi, C. R., & Pol, O. (2022). Treatment with hydrogen-rich water improves the nociceptive and anxio-depressive-like behaviors associated with chronic inflammatory pain in mice. Antioxidants, 11(11), 2153.

 

New Courses at PainExam

Ultrasound Series

Regenerative Medicine

 

Dr. Rosenblum Discusses the uses and theory behind Low Dose Naltrexone for Chronic Pain and Inflammation.

References

Debasish Hota, MD, DM, Anand Srinivasan, MD, Pinaki Dutta, MD, DM, Anil Bhansali, MD, DM, Amitava Chakrabarti, MD, DM, Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy, Pain Medicine, Volume 17, Issue 4, April 2016, Pages 790–791, https://doi.org/10.1093/pm/pnv009

Younger et al: The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain. Clinical Rheumatology (2014) 33:451-459

KTojan, VroomanB.  Low-Dose Naltrexone (LDN) review of Therapeutic Utilization. Med. Sci. 2018, 6,82

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Dr. Rosenblum interviews Amol Soin, MD, ASIPP's (American Society of Interventional Pain Physicians) incoming President.

• Synergy among Pain Physicians
• ASIPP advocating to protect pain patients & physicians
• ABIPP Board Exam
• Ultrasound and Regenerative Pain Courses
• Telehealth and CMS
• Vertebroplasty and Augmentation 

 

 

Dr. Rosenblum considers safe ways to conduct in person Ultrasound Training during the pandemic. Class of 2020 did not even graduate yet and life threw them a nasty curve ball.

Virtual Pain Fellowship at PainExam.com open to Pain Fellows and  Residents.  Free Access Until July 1, 2020

Dr. Rosenblum discusses his plan to help his patients obtain access, maintain and grow his practice in the era of the COVID-19 pandemic. 

Coming Soon the Regenerative Medicine for Spine Disease Course!

 

Dr. Rosenblum discusses COVID-19 and its impact on Pain Management training programs with Lynn Kohan, MD- University of Virginia Pain Fellowship Director

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Dr. Rosenblum discusses his collaboration with ASIPP, and mentions his upcoming Regenerative Spine Course, Trigger finger, DeQuervaine's Syndrome and has started conducting Private Online Ultrasound Zoom Sessions.

For more information email DRosenblum@RMCPain.com

 

A Keyword Review on Nerve Entrapments and the Cervical Spine

• Virtual Pain Fellowship at PainExam.com
• Dr. Rosenblum Discusses Peripheral Stimulation of the Cluneal Nerves on a SPRINT Webinar Tonight!-

Register Here!

This is the registration link: https://register.gotowebinar.com/register/1439533806304538896

This is the donation link: https://ironmanfoundation.donordrive.com/index.cfm?fuseaction=donorDrive.event&eventID=702

 

 

Join us as we hear from some of front line heroes in New York as they tell us about their experiences battling Covid-19.
 
For this webinar, we are raising money for the a great charity, the Ironman Foundation, that will direct funds to those in need here in New York. We know times are tough now, but they are going to get better soon! Please reach down deep in your pockets and contribute what you can in honor of our front line heroes who have gone above and beyond their call. 

Brian Durkin, MD                                                    Sudhir Diwan, MD
President of NYSIPP                                             Executive Director of NYSIPP

 

Dr. Rosenblum interviews a local accupuncturist about his approach to pain and immune optimization. Chinese Herbalists approaches to viral outbreaks.

Luo H, Tang QL, Shang YX, et al. Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs. Chin J Integr Med. 2020;26(4):243–250. doi:10.1007/s11655-020-3192-6

Virtual Pain Fellowship now Live on PainExam.com or VirtualPainFellowship.com

Dr Rosenblum summarizes Dr. Vescusi's efforts to help protect our specialty.
NYSIPP webinar coming up
Advanced Ultrasound Course this weekend on Zoom

 

Click the Link to Watch the Video News Clip on PainExam News

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Dr. Rosenblum serves at AMETD's 2024 Conference as faculty and discusses the safe and accurate usage of Ultrasound to Guide PRP injecitons

Discussed in this lecure:

Knee, Hip, Shoudler, Ligament and Tendon Targets, the ultrasound technique, the evidence for PRP and controversy.  Controversy with respect to the Achilles Tendon!

Other Announcements from NRAP Academy:

• PainExam App is ready for iphone
•  
  •  Pain Management Board Prep migrated to NRAPpain.org
• AnesthesiaExam Board Prep migrated to NRAPpain.org
• PMRExam Board Prep migrated to NRAPpain.org

https://www.nrappain.org/bundles/Virtual-Pain-Fellowship   Live Workshop Calendar

 

 

  Ultrasound Interventional Pain Course Registration    For Anesthesia Board Prep Click Here!

References 
https://rapm.bmj.com/content/rapm/early/2024/07/16/rapm-2024-105593.full.pdf

Disclaimer

Disclaimer: This Podcast, website and any content from NRAP Academy (NRAPpain.org) otherwise known as Qbazaar.com, LLC is  for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. Professionals should conduct their own fact finding, research, and due diligence to come to their own conclusions for treating patients. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Dr. Rosenblum Discusses the upcoming Virtual Pain Fellowship to address gaps in education caused by the COVID-19 Crisis.

 

 

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NY is currently the epicenter of the American COVID-19 Pandemic, Find out what Pain Physicians, and Anesthesiologists are dealing with here first.  The PainExam Podcast and NYSIPP are working non-stop to bring you the latest info to help you stay ahead...

Who should do intubations? Who should Quarantine? Liability in epidural steroid injections?   

What will be the next mesothelioma for lawyers? Steroids during COVID-19?

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Early lessons learned during the NYC COVID-19 Outbreak