Off Script: A Pharma Manufacturing Podcast – Details, episodes & analysis

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Technical and general information from the podcast's RSS feed.

Off Script: A Pharma Manufacturing Podcast

Pharma Manufacturing

News

Frequency: 1 episode/15d. Total Eps: 145

The Off Script podcast offers in-depth interviews and discussions with industry experts about hot-button topics in pharma, and goes behind the scenes of Pharma Manufacturing’s print and online coverage, which follows the industry’s biggest issues surrounding scale-up, technology innovations, regulations and more!

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Data updated on 10/10/2026

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https://www.stevanatogroup.com/en/
6 shares
https://www.pharmamanufacturing.com/home/contact/55247313/greg-slabodkin
5 shares
https://www.emdmillipore.com/US/en
4 shares

https://www.youtube.com/watch?v=eEHJNQV7cNw
2 shares
https://www.youtube.com/watch?v=StsFJgGdGhQ
2 shares
https://www.youtube.com/watch?v=ek3T8xiu1Fw
2 shares

https://www.science.org/doi/10.1126/science.aed8713
1 share

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Score global : 31%

Publication history

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How Life Sciences Manufacturers are Scaling Smarter

Episode 146

Tuesday, October 6, 2026 • Duration 36:19

Life science manufacturers are investing in expanded production capacity while rethinking facility design and technology strategies to improve efficiency, manage costs, and prepare for the future. Balancing upfront investments with long-term operating costs, while navigating the opportunities of automation, single-use technologies and AI, is becoming an increasingly important part of manufacturing decisions.

In this episode of Off Script, we spoke with Peter Walters, fellow of advanced therapies at CRB and a co-author of the company's Horizons: Life Sciences 2026 report, about some key findings from the report. The conversation explored how manufacturers are weighing technology investments against potential cost savings and designing facilities for greater flexibility and efficiency. Walters also discussed how manufacturing strategies may differ across modalities, where AI could have the greatest impact, and why phased implementation, human oversight and careful planning remain important as companies adopt new technologies.

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Connecting Digital Technologies Across Biomanufacturing

Episode 145

Tuesday, September 29, 2026 • Duration 33:18

As biopharmaceutical manufacturers work to accelerate facility timelines while managing complex production environments, greater integration between automation, manufacturing systems and other digital technologies is becoming essential. Moving to more connected manufacturing is also driving companies to rethink how different capabilities are brought together, including a growing focus on integrating project delivery, automation, IT and manufacturing operations.

This episode of Off Script explores that push toward greater integration via biomanufacturing consultancy firm Project Farma’s recent acquisition of SimoTech, a company specializing in manufacturing automation and GMP IT services for the life sciences industry. We spoke with Rich Tree, president of Project Farma, and Pat Desmond, CEO of SimoTech, about what the deal says about the industry’s broader move toward digital integration. They also more broadly discussed barriers to digital transformation, the role of standardization in accelerating projects and supporting flexible manufacturing, and how manufacturers can better connect technology investments with broader manufacturing strategies.

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Are Biomanufacturers Ready for AI?

Episode 144

Tuesday, September 22, 2026 • Duration 27:23

While artificial intelligence is expected to transform biopharmaceutical manufacturing, many manufacturers still face challenges in adopting these technologies at scale. Fragmented data, disconnected manufacturing systems and differences in how information is shared across organizations are creating barriers to AI adoption, raising questions about what manufacturers need to prioritize before investing in more advanced tools.

In this episode of Off Script, we spoke with Justin Byers, founder and CEO of Axio BioPharma, about some of the findings from the company's report, AI in Biomanufacturing: The 2026–2029 Outlook. The conversation explored the gap between AI ambitions and the reality of manufacturing facilities, the importance of building a strong data foundation, and how digital twins could support more advanced biomanufacturing processes. Byers also discussed the challenges of sharing manufacturing data across industry partners, the evolving regulatory expectations around AI in GMP environments, and how AI and digital technologies could reshape biologics manufacturing in the coming years.

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Adapting Biologics Manufacturing to a More Complex Market

Episode 143

Tuesday, September 15, 2026 • Duration 39:03

The pipeline of biologic products entering the market is becoming increasingly complex, and biomanufacturers are incorporating newer technologies and manufacturing strategies into their processes to meet unique production needs. CDMOs, for example, are developing advanced platforms to improve their adaptability and flexibility as the biologics market continues to grow and evolve.

In this episode of Off Script, we spoke with Randal Bass, executive vice president of process design and innovation for Just-Evotec Biologics, a Seattle-based CDMO specializing in the development and manufacturing of biologic products. The conversation explored the challenges of meeting the demands of an expanding but increasingly fragmented biologics market, how single-use and continuous technologies are influencing the industry, and how integrated development strategies can help reduce scale-up risk. Bass also discussed the growing role of AI and machine learning in process development and what could drive broader adoption of advanced biomanufacturing technologies.

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What Will It Take to Reshore Generic Drug Manufacturing?

Episode 142

Tuesday, September 8, 2026 • Duration 23:19

The Trump administration’s plan to impose 100% tariffs on imported generic drugs by August 2028 is spurring conversations about whether manufacturers can realistically reshore production before that deadline. But bringing production back to the U.S. will require more than tariffs alone, as manufacturers consider challenges around cost, capacity, workforce and infrastructure.

In this episode of Off Script, we spoke with Tom Strohl, president of Oliver Wight Americas, about the critical factors manufacturers need to consider to make pharmaceutical reshoring a reality. Strohl discussed the importance of considering the total landed cost of domestic versus overseas production, the capacity and workforce challenges associated with large-scale reshoring, and why moving API production back to the U.S. could prove even more difficult than finished-dose manufacturing. We also discussed if manufacturers have enough time to prepare for the 2028 tariff cliff, how manufacturers can balance cost with the long-term benefits of a more resilient domestic supply chain, and how AI and robotics could support a new generation of domestic manufacturing.

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How AI-Based Bioreactors Can Improve Enzyme Production

Episode 141

Tuesday, September 1, 2026 • Duration 28:30

Researchers have developed a new sensor-enabled bioreactor that uses machine learning technology for improved enzyme production. This advanced technology—created by researchers at Iowa State University and Novonesis, with funding by BioMADE—pairs continuous monitoring with AI-guided control to give manufacturers a faster, more precise way to manage enzyme production.

In this episode of Off Script, we connected with Mike Hess, senior regional technology manager at Novonesis, and David Nathan, program director at BioMADE, to discuss the development of the new bioreactor and how real-time monitoring and AI-based control help manufacturers automate previously manual processes, improve batch consistency, and ultimately accelerate the path to market. The conversation also explored how the project led to the development of low-cost bioreactors that researchers are now working to turn into hands-on bioprocessing educational kits for students.

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Blow-Fill-Seal and the Future of Sterile Ophthalmic Manufacturing

Episode 140

Tuesday, August 25, 2026 • Duration 24:28

Sterile ophthalmic manufacturing is facing growing demand as more preservative-free therapies move through development, while manufacturers also contend with increasingly stringent expectations around contamination control, inspection, and quality. Blow-fill-seal (BFS) technology offers a closed, highly automated approach that can reduce contamination risks while producing billions of unit doses at scale.

In this episode of Off Script, we spoke with Jody Chastain, CEO of The Ritedose Corporation, about the role of BFS in the future of sterile ophthalmic manufacturing. Chastain discussed how automation is improving manufacturing speed and container integrity, why packaging decisions are increasingly being made earlier in development, and how manufacturers are adapting to evolving FDA expectations and Annex 1 principles. He also explored manufacturing redundancy, AI-enabled quality operations, automated inspection, and the future of BFS technology.

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Can Radiopharma Manufacturing Keep Pace with Demand?

Episode 139

Tuesday, August 18, 2026 • Duration 29:46

Radiopharmaceuticals are a rapidly growing area of oncology, fueled by advances in targeted therapies and expanding product pipelines. But bringing these therapies from development to commercialization presents unique manufacturing challenges, from isotope supply and specialized GMP facilities to the “just-in-time” distribution models required by the short half-lives of these radioactive medicines.

In this episode of Off Script, we spoke with Thijs Spoor, CEO of Perspective Therapeutics, about the current state of radiopharmaceutical manufacturing and what the industry needs to support the next phase of growth. Spoor discussed why manufacturing capacity has become one of the industry's biggest bottlenecks, how companies are approaching facility expansion and supply chain resilience, and why distributed manufacturing networks are integral. He also touched on workforce challenges, evolving regulatory expectations, and continued investment that is supporting the industry's growth.

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AI’s Impact on Quality Management in Pharma Manufacturing

Episode 138

Tuesday, August 11, 2026 • Duration 25:03

The demands on pharmaceutical manufacturing quality teams are growing as they manage larger volumes of data driven by increasingly complex therapies and evolving regulatory expectations. In response, artificial intelligence is emerging as a powerful tool to help quality professionals synthesize information more efficiently, improve consistency across investigations, and support more informed decision-making.

In this episode of Off Script, we spoke with Charlie Lickfold, Chief Technology Officer at Catalent, about how the company is deploying AI to modernize pharmaceutical quality management. Lickfold explains why advanced modalities like cell and gene therapies are driving demand for AI-enabled quality systems, how Catalent’s new QAI platform is assisting in quality management, and why human oversight remains essential in regulated quality operations. He also discusses evolving regulatory expectations, AI governance, and organizational strategies that can support successful enterprise AI deployment.

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Single-Use Technologies and the Future of Flexible Biomanufacturing

Episode 137

Tuesday, August 4, 2026 • Duration 34:24

Single-use technologies have reshaped biopharma manufacturing facility design, capacity strategy, and flexibility over the past decade. The industry has expanded with a growing range of targeted therapies and emerging modalities, which has led to manufacturers adopting single-use systems to meet demand. The shift has enabled more flexible facilities, faster product changeovers, and manufacturing strategies better suited to scaling next-generation biologics.

In this episode of Off Script, we spoke with Charlie Heise, associate director of Bioprocess Strategy and Development at Fujifilm Biotechnologies, about how single-use technologies have transformed facility design over the past decade and where things are headed. Heise discusses the industry's shift from process-specific plants to flexible manufacturing platforms, the growing role of single-use systems in continuous manufacturing and process intensification, and why standardization and digital integration are essential. He also explores how hybrid manufacturing models, regional production, and evolving therapeutic modalities will shape the next generation of biopharma manufacturing.

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Off Script: A Pharma Manufacturing Podcast – Details, episodes & analysis

Podcast details

Recent rankings

Apple Podcasts

Spotify

Shared links between episodes and podcasts

RSS feed quality and score

Publication history

Latest published episodes

Related Shows Based on Content Similarities

Related Shows Based on Content Similarities

Apple Podcasts

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Off Script: A Pharma Manufacturing Podcast – Details, episodes & analysis

Podcast details

Recent rankings

Apple Podcasts

Spotify

Shared links between episodes and podcasts

Other90

YouTube6

Science1

RSS feed quality and score

Publication history

Latest published episodes

Similar podcasts and content

Related Shows Based on Content Similarities

Related Shows Based on Content Similarities

Other90

YouTube6

Science1

Apple Podcasts

Spotify