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Explore every episode of the podcast Ninja Nerd

Dive into the complete episode list for Ninja Nerd. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

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TitlePub. DateDuration
Pancreatic and Hepatobiliary Cancer06 Nov 202500:37:00

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In this episode of the Ninja Nerd Podcast, Zach and Rob explore pancreatic and hepatobiliary cancers through four patient cases packed with clinical pearls.

We begin with a 63-year-old man presenting with painless jaundice, pruritus, and weight loss. Zach walks through the differential for obstructive cholestasis, covering malignant (pancreatic head cancer, cholangiocarcinoma, ampullary tumors) and benign (stones, strictures) causes. We emphasize RUQ ultrasound's role in assessing for ductal dilation, followed by pancreas-protocol CT and EUS-guided FNA to confirm pancreatic adenocarcinoma. Management hinges on resectability, with Zach outlining surgical criteria and adjuvant chemotherapy options.

Next, we discuss a 58-year-old man with cirrhosis and a newly detected liver nodule on routine surveillance. With an elevated AFP and classic arterial enhancement with portal venous washout on imaging, the diagnosis of hepatocellular carcinoma (HCC) becomes clear. We outline curative options for early-stage disease—including surgical resection and radiofrequency ablation—and review the role of transplant under Milan criteria.

Case three features a 48-year-old woman with primary sclerosing cholangitis and rising cholestasis, prompting a focused discussion on perihilar cholangiocarcinoma (Klatskin tumor). We highlight the role of MRCP for mapping strictures, followed by ERCP with brushings to confirm malignancy. With localized disease, Zach walks through surgical resection with liver wedge + bile duct excision, followed by adjuvant capecitabine, and offers guidance on palliative strategies for unresectable disease.

Finally, we examine a 72-year-old woman with a porcelain gallbladder and new mass—raising suspicion for gallbladder carcinoma. The case underscores the importance of RUQ ultrasound for polypoid lesions and how staging dictates surgery. For early T1a disease, simple laparoscopic cholecystectomy is curative; deeper invasion requires extended cholecystectomy.

We close with a summary of diagnostic strategies: ultrasound for ductal or gallbladder disease, triphasic CT or MRI for liver masses, MRCP for PSC patients, and pancreas-protocol CT for head-of-pancreas tumors. Each case reinforces the principle: start broad, refine with the right imaging, and let stage drive treatment.

Let’s get into it, Ninja Nerds!

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Esophageal & Gastric Cancer23 Oct 202500:28:56

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In this episode of the Ninja Nerd Podcast, Zach and Rob discuss two high-yield, board-relevant cases highlighting the diagnosis, staging, and treatment of esophageal adenocarcinoma and intestinal-type gastric adenocarcinoma.

We begin with a 56-year-old man presenting with progressive dysphagia and unintentional weight loss. Zach breaks down the concern for distal esophageal adenocarcinoma in the long-standing GERD and Barrett's esophagus setting. We walk through the stepwise diagnostic process—starting with barium swallow, followed by EGD with biopsy, and endoscopic ultrasound (EUS) and CT chest/abdomen/pelvis for staging. Based on a staging result of T2 N1 M0, we discuss the standard approach of neoadjuvant chemoradiation followed by transthoracic esophagectomy, with comparisons to management of early mucosal disease and metastatic presentations.

Next, we pivot to a 63-year-old woman with chronic Helicobacter pylori gastritis, now presenting with early satiety, epigastric discomfort, and melena. The focus shifts to intestinal-type gastric adenocarcinoma, classically found along the lesser curvature. We review the appropriate use of EGD with biopsy as the first test in alarm dyspepsia, followed by CT imaging and EUS to assess depth and nodal involvement. With a staging result of T1b N0, we emphasize the role of subtotal (distal) gastrectomy with D2 lymph node dissection, and outline when perioperative chemotherapy or palliation (e.g., GOO stents, systemic chemo, trastuzumab for HER2⁺ tumors) becomes necessary.

Finally, we conclude with a rapid comparison of the two cases, highlighting shared themes: the importance of depth of invasion, nodal status, and the shift from endoscopic resection to surgical and systemic therapies based on stage.

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Amyloidosis14 Mar 202500:30:35

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), highlighting their unique pathogenesis, clinical manifestations, and diagnostic approaches.

Our discussion covers the systemic vs. localized forms of the disease, exploring how amyloid deposition can impact critical organs like the heart (restrictive cardiomyopathy), kidneys (nephrotic syndrome), nervous system (autonomic and peripheral neuropathy), and gastrointestinal tract. We also walk through essential diagnostic tools, including serum and urine electrophoresis, fat pad biopsy with Congo red staining, mass spectrometry, and advanced imaging techniques like cardiac MRI and PYP scanning for ATTR amyloidosis.

Finally, we break down the latest treatment strategies, from chemotherapy and autologous stem cell transplant for AL amyloidosis. Whether you’re preparing for exams, rotations, or just want to master this challenging topic, this episode is packed with high-yield insights to boost your understanding!

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Lymphoma07 Mar 202500:34:14

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, examining the role of Reed-Sternberg cells, CD markers, and genetic mutations that define these malignancies.

Our discussion includes high-yield diagnostic tools like lymph node biopsy, flow cytometry, PET/CT imaging, and molecular studies, helping you differentiate between indolent and aggressive subtypes. We also analyze cutting-edge treatments, including immunotherapy, targeted monoclonal antibodies (e.g., rituximab), chemotherapy regimens like R-CHOP, and the role of stem cell transplantation in refractory cases.

Additionally, we cover disease progression, prognostic factors, and complications such as tumor lysis syndrome and secondary malignancies. Whether you’re studying for boards, preparing for clinical rotations, or just love hematology-oncology, this episode is packed with high-yield pearls you don’t want to miss!

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Chronic Leukemias28 Feb 202500:35:23

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), discussing the role of BCR-ABL in CML and the implications of smudge cells and monoclonal B-cell proliferation in CLL. Our conversation covers key diagnostic tools such as PCR, flow cytometry, and blood smear findings, as well as cutting-edge treatment options like tyrosine kinase inhibitors (TKIs) for CML and targeted monoclonal antibody therapy for CLL. We also discuss disease progression, complications like Richter transformation, and indications for therapy in asymptomatic patients. This high-yield episode is perfect for both exam prep and clinical application—enjoy and support us below!

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Acute Leukemias21 Feb 202500:45:29

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL), focusing on the genetic mutations, risk factors, and cellular mechanisms driving these malignancies. Our discussion includes high-yield diagnostic approaches such as peripheral blood smear, bone marrow biopsy, flow cytometry, and cytogenetic analysis. We also cover essential treatment strategies, including induction chemotherapy, targeted therapies, and hematopoietic stem cell transplantation (HSCT), while highlighting critical complications like tumor lysis syndrome and leukostasis. This episode is packed with clinically relevant insights and board exam pearls—tune in and support us below!

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Myeloproliferative Neoplasia14 Feb 202500:37:25

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myeloproliferative Neoplasms, covering their pathophysiology, clinical presentation, and management. We discuss Polycythemia Vera, Essential Thrombocythemia, Chronic Myeloid Leukemia, and Primary Myelofibrosis, focusing on key mutations like JAK2, CALR, and BCR-ABL. Our discussion includes diagnostic tools such as peripheral blood smear, bone marrow biopsy, and laboratory markers like erythropoietin levels, leukocyte alkaline phosphatase, and BCR-ABL testing. We also review treatment options, including tyrosine kinase inhibitors, cytoreductive therapy, and JAK inhibitors, as well as complications like thrombosis, bleeding, and transformation to acute leukemia. This episode provides a high-yield review for exams and clinical practice. Enjoy the episode, and support us below!

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Plasma Cell Disorders07 Feb 202500:27:25

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström macroglobulinemia, as well as the role of paraproteins and their clinical implications. We discuss diagnostic approaches such as serum protein electrophoresis (SPEP), immunofixation, and bone marrow biopsy, along with treatment options like proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. We also explore complications like hypercalcemia, renal impairment, anemia, and bone lesions, ensuring a high-yield overview for exams and clinical practice. Enjoy the episode, and support us below!

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Antiplatelets, Anticoagulants, and Thrombolytics31 Jan 202500:47:19

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Antiplatelets, Anticoagulants, and Thrombolytics, focusing on their mechanisms and clinical uses. Topics include the pharmacology of antiplatelet agents such as aspirin and P2Y12 inhibitors, the role of anticoagulants like heparins, direct oral anticoagulants (DOACs), and warfarin in preventing thromboembolic events, and the use of thrombolytics like tPA in acute ischemic stroke and myocardial infarction. We also discuss strategies for managing bleeding risks, reversal agents, and clinical considerations for optimizing anticoagulation therapy. Enjoy the episode, and support us below!

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Hypercoagulable States24 Jan 202500:39:33

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Hypercoagulable States, covering key disorders and their clinical significance. Topics include Antiphospholipid Syndrome (APLS), its role in thrombosis and pregnancy loss; Factor V Leiden Mutation, the most common inherited thrombophilia; and Prothrombin Gene Mutation and its increased clotting risk. We also explore Protein C and S Deficiency, Antithrombin Deficiency, and acquired states like Cancer-Associated Thrombosis, Heparin-Induced Thrombocytopenia (HIT), and Paroxysmal Nocturnal Hemoglobinuria (PNH). Tune in to learn more, and support us below!

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Coagulopathy17 Jan 202500:39:33

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Coagulopathy, focusing on key bleeding and clotting disorders. Topics include Hemophilia A and B, their genetic causes, and modern treatments; Von Willebrand Disease (vWD), the most common inherited bleeding disorder; and Heparin-Induced Coagulopathy, with its paradoxical effects. We also cover Acquired Factor VIII Inhibitors in autoimmune and malignancy settings, Vitamin K Deficiency as a cause of bleeding, Disseminated Intravascular Coagulation (DIC) and its management challenges, and coagulopathy in Cirrhosis, linking liver dysfunction to bleeding and thrombosis. Enjoy the episode, and support us below!

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Platelet Disorders29 Nov 202400:58:22

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Platelet Disorders, breaking down the essential concepts and clinical applications. We will discuss Heparin-Induced Thrombocytopenia (HIT), focusing on its pathophysiology and management. Learn about Antiphospholipid Syndrome (APLS) and its role in thrombosis and pregnancy complications. We’ll also cover Disseminated Intravascular Coagulation (DIC), including its triggers and treatment strategies, and Hemolytic Uremic Syndrome (HUS), with an emphasis on its pediatric presentations. Dive into Thrombotic Thrombocytopenic Purpura (TTP) and its life-threatening manifestations, Von Willebrand Disease (vWD) as the most common inherited bleeding disorder, and Immune Thrombocytopenic Purpura (ITP), highlighting its diagnostic approach and treatment. Enjoy the podcast, and please support us below!

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Testicular Cancer09 Oct 202500:20:36

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In this episode of the Ninja Nerd Podcast, Zach and Rob discuss testicular cancer, one of the most common solid tumors in young adult men.

We begin with a classic clinical vignette of a young male presenting with a painless testicular mass. From there, we explore the epidemiology and key risk factors for testicular germ cell tumors, including cryptorchidism, family history, and Klinefelter syndrome (in rare cases of nonseminomatous tumors like mediastinal choriocarcinoma). We then distinguish between the two major types: seminomas and nonseminomas—breaking down their unique biological behaviors and typical age distributions.

Our discussion dives deep into the pathophysiology of germ cell tumors, highlighting tumor markers like AFP, β-hCG, and LDH, and how they guide diagnosis and treatment. We walk through the classic presentations of seminomas (often β-hCG positive and radiosensitive) versus nonseminomas (associated with aggressive behavior and elevated AFP/β-hCG levels).

Next, we focus on the diagnostic workup, including scrotal ultrasound, serum tumor marker analysis, and CT imaging for staging. We emphasize the importance of inguinal orchiectomy as both a diagnostic and therapeutic intervention.

Finally, we cover treatment strategies based on stage and histology—ranging from surveillance and radiation therapy for early-stage seminomas to cisplatin-based chemotherapy regimens and retroperitoneal lymph node dissection (RPLND) for advanced or nonseminomatous disease.

Don’t miss it—let’s get into it, Ninja Nerds!

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Blood Transfusions22 Nov 202401:00:31

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive into blood transfusions, breaking down the essential components and clinical uses. We will discuss packed red blood cell transfusions (PRBC) for anemia management, platelet transfusions for thrombocytopenia and bleeding risk, and the role of Fresh Frozen Plasma (FFP) transfusions in reversing anticoagulation or treating coagulopathies. You will also learn about Prothrombin Complex Concentrate (PCC) transfusions for rapid anticoagulant reversal, Cryoprecipitate Transfusions for fibrinogen replacement, and how to manage complications like transfusion-related acute lung injury (TRALI). Lastly, we will tackle the massive transfusion protocol (MTP), also known as a Code Crimson, highlighting its life-saving importance in critical care settings. Enjoy the podcast, and please support us below!

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Macrocytic Anemia15 Nov 202400:31:44

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Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode dives into Macrocytic Anemia. During this discussion, we will review B12 Deficiency Anemia, Folate Deficiency Anemia, and Non-Megaloblastic Anemia. We have three cases we will be working through, so please listen along and see if you can figure out these cases.  Enjoy the podcast, and be sure to support us below!

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Normocytic Anemia08 Nov 202401:15:58

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Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode dives into Normocytic Anemia, exploring the primary types, including Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria (PNH), G6PDH Deficiency, Hereditary Spherocytosis, Autoimmune Hemolytic Anemia (AIHA), Sickle Cell Anemia, Microangiopathic Hemolytic Anemia (MAHA), Acute Blood Loss Anemia (ABLA). Enjoy the podcast, and be sure to support us below!

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Microcytic Anemia02 Nov 202400:42:19

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Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode is on Microcytic Anemia, covering the major types such as iron deficiency anemia, thalassemia, anemia of chronic disease, and sideroblastic anemia. Enjoy the podcast and support us below!

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Vasculitis25 Oct 202400:58:24

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Vasculitis. You'll learn about the causes, symptoms, and treatment options for Large, Medium, and Small Vessel Vasculitis. We'll discuss clinical cases to highlight critical diagnostic and management strategies for diseases such as Giant Cell Arteritis, Takayasu's Arteritis, Polyarteritis Nodosa, Kawasaki Disease, Granulomatosis with Polyangiitis (GPA), Eosinophilic Granulomatosis with Polyangiitis (EGPA), Microscopic Polyangiitis (MPA), IgA Vasculitis, and Cryoglobulinemic Vasculitis. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Vasculitis. Please support us below!

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Nephrolithiasis18 Oct 202400:35:11

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Nephrolithiasis. You'll learn about the causes, symptoms, and treatment options for Nephrolithiasis. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Nephrolithiasis. Please support us below!

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Diuretics11 Oct 202400:22:34

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Diuretics. You'll learn about the causes, symptoms, and treatment options for Diuretics. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Diuretics. Please support us below!

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IV Fluids04 Oct 202400:21:05

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss IV Fluids. You'll learn about the causes, symptoms, and treatment options for IV Fluids. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of IV Fluids. Please support us below!

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Approach to Hematuria27 Sep 202400:19:34

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss the Approach to Hematuria. You'll learn about the causes, symptoms, and treatment options for Hematuria. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Hematuria. Please support us below!

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Cystic Kidney Disease20 Sep 202400:19:51

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Cystic Kidney Disease. You'll learn about the causes, symptoms, and treatment options for Cystic Kidney Disease. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Cystic Kidney Disease. Please support us below!

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Urinary Tract Malignancies25 Sep 202500:29:41

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In this episode of the Ninja Nerd Podcast, Zach and Rob dive into the essential clinical and pathophysiologic features of urinary tract malignancies, beginning with renal cell carcinoma (RCC) and followed by urothelial carcinoma of the bladder.

We start with a patient case of renal cell carcinoma, exploring the epidemiology and risk factors such as smoking, obesity, hypertension, and inherited syndromes like von Hippel-Lindau disease. The discussion focuses on the pathophysiology of clear cell RCC, particularly the loss of VHL gene function and dysregulation of the HIF pathway, leading to increased angiogenesis.

We review the classic triad of RCC—flank pain, hematuria, and a palpable abdominal mass—along with common paraneoplastic syndromes, including polycythemia and hypercalcemia. Diagnostic evaluation includes CT imaging of the abdomen and pelvis, with treatment strategies ranging from partial or radical nephrectomy to immune checkpoint inhibitors and targeted therapies for advanced disease.

Next, we shift to a patient with urothelial carcinoma, highlighting epidemiologic risks like tobacco use, occupational exposures, chronic inflammation, and cyclophosphamide.

Clinical signs such as painless hematuria, irritative voiding symptoms, and hydronephrosis are discussed alongside the diagnostic approach: urine cytology, cystoscopy with biopsy, and CT urography. Management strategies include TURBT, intravesical BCG, radical cystectomy, and systemic chemotherapy, based on staging and risk.

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Glomerular Diseases23 Aug 202400:41:43

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Glomerular Diseases, including Nephrotic and Nephritic Syndrome. You'll learn about the causes, symptoms, and treatment options for Glomerular Diseases. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Glomerular Diseases. Please support us below!

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Chronic Kidney Disease (CKD)16 Aug 202400:42:52

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Chronic Kidney Disease (CKD). You'll learn about the causes, symptoms, and treatment options for CKD. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Chronic Kidney Disease (CKD). Please support us below!

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Acute Kidney Injury (AKI)09 Aug 202400:48:31

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Acute Kidney Injury (AKI). You'll learn about the causes, symptoms, and treatment options for Prerenal, Intrarenal, and Postrenal AKI. We'll discuss three clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Acute Kidney Injury (AKI). Please support us below!

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Calcium Disorders02 Aug 202400:36:42

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Calcium Disorders. You'll learn about the causes, symptoms, and treatment options for Hypocalcemia and Hypercalcemia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Calcium Disorders. Please support us below!

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Potassium Disorders26 Jul 202400:32:42

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Potassium Disorders. You'll learn about the causes, symptoms, and treatment options for Hypokalemia and Hyperkalemia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Potassium Disorders. Please support us below!

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Sodium Disorders19 Jul 202400:33:46

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Sodium Disorders. You'll learn about the causes, symptoms, and treatment options for Hyponatremia and Hypernatremia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Sodium Disorders. Please support us below!

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Acid-Base Disorders12 Jul 202400:53:24

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Acid-Base Disorders. You'll learn about the causes, symptoms, and treatment options for Metabolic Acidosis, Metabolic Alkalosis, Respiratory Acidosis, and Respiratory Alkalosis. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of Acid-Base Disorders. Please support us below!

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Volume Disorders14 May 202400:33:29

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Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore the intricacies of hypovolemia and hypervolemia. You'll learn about the causes, symptoms, and treatment options for both conditions. We'll discuss clinical cases to highlight key diagnostic and management strategies, ensuring you're well-prepared for your exams and clinical practice. Whether you're a medical student, resident, or practicing clinician, this episode offers valuable insights to enhance your understanding of volume disorders.

Ninja Nerd Website | https://ninjanerd.org

Ninja Nerd Podcast | https://podcast.ninjanerd.org

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#ninjanerd #podcast #volumedisorders

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Hyperaldosteronism26 Jan 202300:26:47

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This week, Rob and Zach will be talking about Hyperaldosteronism.

We will be discussing the following topics within this episode on Hyperaldosteronism!

  • The Aldosterone Pathway and Normal Physiology
  • Aldosterone Target Organs & Effects
  • Causes of High Aldosterone
  • Diagnostic Workup
  • Treatment

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/hyperaldosteronism

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Cushing's Syndrome19 Jan 202300:27:58

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This week, Rob and Zach will be talking about Cushing's Syndrome.

We will be discussing the following topics within this episode on Cushing's Syndrome!

  • The Cortisol Pathway and Normal Physiology
  • Cortisol Target Organs & Effects
  • Causes of High Cortisol
  • Diagnostic Workup
  • Treatment

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/cushings-syndrome

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Prostate Cancer11 Sep 202500:34:59

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Ninja Nerds!

In this episode of the Ninja Nerd Podcast, Zach and Rob break down the essential clinical and pathophysiologic features of Prostate Cancer, one of the most common malignancies affecting men worldwide.

We begin with the epidemiology and risk factors, highlighting age, race, family history, and androgen exposure. From there, we explore the pathogenesis of prostate cancer, focusing on the role of androgen receptor signaling.

The discussion covers clinical manifestations, including urinary symptoms, back pain from bone metastases, and signs of spinal cord compression. We also examine the utility and controversy surrounding PSA screening, along with digital rectal exam findings and the importance of prostate biopsy for histologic confirmation, emphasizing Gleason scoring and its prognostic significance.

Next, we analyze imaging modalities like multiparametric MRI and bone scans, and review treatment strategies based on risk stratification, ranging from active surveillance and radical prostatectomy to radiation therapy and androgen deprivation therapy (ADT).

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Anxiolytic & Hypnotic Drugs12 Jan 202300:43:39

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This week, Rob and Zach will be talking about Anxiolytic & Hypnotic Drugs.

We will be discussing the following topics within this episode on Anxiolytic & Hypnotic Drugs!

  • Pathophysiology
    • Anxiety
    • Insomnia
  • Mechanism of Action
    • Anxiolytics
    • Hypnotics
  • Treatment Approach
    • Anxiety
    • Insomnia
  • Adverse Drug Reactions
    • Anxiolytics
    • Hypnotics

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/anxiolytic-hypnotic-drugs

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Drugs for Epilepsy05 Jan 202300:27:29

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This week, Rob and Zach will be talking about Drugs for Epilepsy.

We will be discussing the following topics within this episode on Drugs for Epilepsy!

  • Classification between Seizures & Epilepsy
  • Causes / Pathophysiology
  • Mechanism of Anti Epileptic Drugs (AEDs)
  • Clinical Approach to Epilepsy
  • Adverse Drug Reactions & Systematic Involvement

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/drugs-for-epilepsy

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Parkinson's Disease Drugs29 Dec 202200:38:02

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This week, Rob and Zach will be talking about Parkinson's Disease (PD) Drugs

We will be discussing the following topics within this episode on Parkinson's Disease (PD) Drugs!

  • Anatomy of Basal Ganglia
    • Direct vs. Indirect Pathway
  • Pathophysiology and Mechanism of Action of PD Drugs
  • PD Drug Categories
    • L-dopa & Carbidopa
    • Dopamine Agonists
    • COMT-Inhibitors
    • MAO-B-Inhibitors
    • Amantadine
    • Anticholinergics
  • Complications
  • Adverse Drug Effects

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/parkinsons-disease-drugs

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Hypernatremia22 Dec 202200:26:11

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This week, Rob and Zach will be talking about Hypernatremia.

We will be discussing the following topics within this episode on Hypernatremia!

  • Introduction to Hypernatremia
  • Causes / Pathophysiology
  • Clinical Features
  • Physical Exam Findings
  • Diagnosis
  • Treatment

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/hypernatremia

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Hyponatremia15 Dec 202201:19:21

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This week, Rob and Zach will be talking about Hyponatremia.

We will be discussing the following topics within this episode on Hyponatremia!

  • Introduction to Hyponatremia
  • Causes / Pathophysiology
  • Clinical Features
  • Physical Exam Findings
  • Diagnosis
  • Treatment

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/hyponatremia

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Autonomic Pharmacology: Muscarinic Antagonists08 Dec 202200:24:05

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This week, Rob and Zach will be talking about Muscarinic Antagonists within our short four part series on Autonomic Pharmacology

We will be discussing the following topics within this episode on Muscarinic Antagonists!

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/autonomic-pharmacology-muscarinic-antagonists

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Autonomic Pharmacology: Cholinergic Agonists01 Dec 202200:36:11

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This week, Rob and Zach will be talking about Cholinergic Agonists within our short four part series on Autonomic Pharmacology

We will be discussing the following topics within this episode on Cholinergic Agonists!

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/autonomic-pharmacology-cholinergic-agonists

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Autonomic Pharmacology: Adrenergic Antagonists24 Nov 202200:42:18

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This week, Rob and Zach will be talking about Adrenergic Antagonists within our short four part series on Autonomic Pharmacology

We will be discussing the following topics within this episode on Adrenergic Antagonists!

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org

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Autonomic Pharmacology: Adrenergic Agonists17 Nov 202201:11:14

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This week, Rob and Zach will be talking about Adrenergic Agonists within our short four part series on Autonomic Pharmacology

We will be discussing the following topics within this episode on Adrenergic Agonists!

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/autonomic-pharmacology-adrenergic-agonists

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Anticoagulants, Thrombolytics, and Antiplatelet Agents10 Nov 202201:13:37

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This week, Rob and Zach will be talking about Anticoagulants, Thrombolytics, and Antiplatelet Agents

We will be discussing the following topics within this episode on Anticoagulants, Thrombolytics, and Antiplatelet Agents!

  • Hemostasis: Coagulation Cascade, Extrinsic + Intrinsic Pathway
  • Anticoagulants:
    • Heparin
      • UFH
      • LMWH
      • Fondaparinux 
    • Direct Factor Inhibitors
      • Xa Inhibitors:
        • Rivaroxaban
        • Apixaban
        • Edoxaban
      • Thrombin Inhibitors:
        • Dabigatran
        • Argatroban
        • Bivalirudin
    • Vitamin K Antagonists:
      • Warfarin (Coumadin)
  • Thrombolytics (tPA):
    • Alteplase
    • Reteplase
    • Tenecteplase
    • Streptokinase
    • Urokinase
  • Antiplatelets:
    • Aspirin
    • P2y12 Receptor Blockers:
      • Clopidogrel
      • Ticagrelor
      • Prasugrel
      • Ticlopidine
    • GP2b/3a Inhibitors:
      • Abciximab
      • Eptifibatide
      • Tirofiban
    • PDE-3 Inhibitors:
      • Cilostazol
  • Anticoagulants, Thrombolytics, Antiplatelet Agents MOA
  • Therapeutic Indications
  • Adverse Drug Reactions (ADR's)
  • Drug Complications

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/anticoagulants-thrombolytics-and-antiplatelet-agents

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Colorectal Cancer04 Sep 202500:37:25

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Ninja Nerds!

In this episode of the Ninja Nerd Podcast, Zach and Rob discuss Colorectal Cancer. This comprehensive discussion focuses on the clinical presentation, pathogenesis, and management of one of the most common malignancies encountered in clinical practice.

We start by breaking down the epidemiology and risk factors, covering both sporadic and inherited forms—highlighting Lynch syndrome and familial adenomatous polyposis (FAP). From there, we analyze the adenoma-carcinoma sequence and key molecular mutations such as APC, KRAS, and p53.

The conversation then shifts to clinical features and how tumor location influences presentation—such as iron deficiency anemia in right-sided lesions and obstructive symptoms in left-sided tumors. We’ll walk through the diagnostic workup, including colonoscopy findings, biopsy, and imaging, and review the role of CEA as a tumor marker.

Finally, we discuss treatment strategies based on TNM staging, including surgical resection, adjuvant chemotherapy regimens like FOLFOX, and the importance of routine screening protocols for early detection.

This episode has high-yield insights to help you excel on exams and confidently approach colorectal cancer in clinical settings.

🎧 Tune in, take notes, and let’s conquer colorectal cancer—one polyp at a time.

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Diuretics03 Nov 202200:35:15

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This week, Rob and Zach will be talking about Diuretics

We will be discussing the following topics within this episode on Diuretics!

  • Defining a Diuretic
  • Diuretics Drug Categories:
    • Osmotic Diuretics
    • Carbonic Anhydrase Inhibitors
    • Loop Diuretics
    • Thiazide Diuretics
    • Potassium Sparing Diuretics
  • Diuretics MOA
  • Therapeutic Indications
  • Adverse Drug Reactions (ADR's)

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/diuretics

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Antiarrhythmic Drugs27 Oct 202200:52:56

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This week, Rob and Zach will be talking about Antiarrhythmic Drugs

We will be discussing the following topics within this episode on Antiarrhythmic Drugs!

  • Defining an Arrhythmia
  • Pathophysiology of an Arrhythmia:
    • Abnormal Automaticity
    • Increased Triggered Activity
    • Re-Entrant Circuits
  • Antiarrhythmic Drug Categories:
    • Class I: Sodium Channel Blockers (Type Ia, Ib, Ic)
    • Class II: Beta Blockers
    • Class III: Potassium Channel Blockers
    • Class IV: Calcium Channel Blockers
    • Class V: Miscellaneous
      • Adenosine
      • Magnesium
      • Digoxin

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https:// www.ninjanerd.org/podcast/antiarrhythmic-drugs 

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Drugs for Heart Failure20 Oct 202201:00:13

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This week, Rob and Zach will be talking about Drugs for Treating Heart Failure - Let's master this topic together, Ninja Nerds!

We will be discussing the following topics within this episode on Drugs for Heart Failure!

  • Defining Congestive Heart Failure (CHF)
  • Pathophysiology of CHF
  • Drug Categories used to Treat Heart Failure:
    • Beta Blockers
    • ACE Inhibitors
    • Angiotensin II Receptor Blockers (ARBs)
    • Neprilysin Inhibitors + ARB (Known as ARNi)
    • Hydralazine + Isosorbide Dinitrate
    • Diuretics
    • Ivabradine
    • Positive Inotropes (Digoxin, Dobutamine, Milrinone, Dopamine)
  • NYHA Heart Failure Classification
  • Acute Heart Failure
    • Causes
    • Pathophysiology
    • Complications
    • Treatment

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/drugs-for-heart-failure

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Drugs for Hyperlipidemia13 Oct 202200:39:51

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This week, Rob and Zach will be talking about Drugs for Treating Hyperlipidemia. Make sure you stick around for the entire episode, this one is a beauty, unlike my coronary vessels...

We will be discussing the following topics within this episode on Hyperlipidemia Drugs!

  • Defining Hyperlipidemia
  • Pathophysiology & Complications of Hyperlipidemia
  • Drug Categories of Hyperlipidemia Drugs:
    • HMG CoA Reductase Inhibitors
    • Niacin
    • Fibrates
    • Bile Acid Sequestrants
    • Cholesterol Absorption Inhibitors
    • PCSK9 Inhibitors
  • ACC/AHA Guidelines for Hyperlipidemia
  • Combination Therapy

To follow along with Notes & Illustrations for our podcasts please become a member on our website! https:// www.ninjanerd.org/podcast/drugs-for-hyperlipidemia

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