In this episode Dr. Tiago Outeiro talks with Dr. Andrew Siderowf about the exciting new results in his most recent publication on alpha-synuclein seed amplification assay. Read the article.

Dr. Sarah Camargos interviews Dr. Zhonghbo Chen and Prof. Henry Houlden, first and senior author of a MDJ paper exploring a GGC repeat expansion in the ZFHX3 gene associated with spinocerebellar ataxia type 4. They describe a criative methodology to find a gene in a family with a Swedish ancestry.
Journal CME is available until April 04, 2025 Read the article.

In this issue Dr. Filip Sheperjans shares the results of the article published in the March 2020 issue of the Movement Disorders journal on the effect of antibiotic exposure on the risk of developing Parkinson's disease. Read the article

Dr. Matarazzo interviews Émeline Courtois about the recently published article on machine learning approach to discover marketed drugs that could have an impact on the development of Parkinson's disease. Interestingly, furosemide and adrenergic drugs showed a potential protective effect in this very large cohort.
Journal CME is available until January 19, 2024 Read the article.

Award Replay: Dr. Eduardo Fernandez interviews Professor Günther Deuschl and Dr. Robin Wolke on their article on the challenges levodopa poses when predicting the outcome of subthalamic deep brain stimulation — which was recently named the Movement Disorders Clinical Practice journal Research Article of the Year. Read the article

Dr. Sara Schaefer speaks with Dr. Beatrice Heim, author of the MDCP Review Article of the Year 2023, about alpha-synuclein seed amplification assays of the CSF and their use in the diagnosis of synucleinopathies. Read the article

Prof. Alessio Di Fonzo shares the results of his award winning, multi-center work examining genetic data from people with early-onset PD in hopes of highlighting the difficulties in interpreting genetic variants emerging from NGS-multigene panels. Read the article.

Dr. Poewe and Dr. Mahlknecht discuss the details of their Review Article of the Year on what we know about how DBS in Parkinson's disease alters symptoms, disability, survival, and more in this special episode. Read the article

Dr. Sara Schaefer interviews Dr. Jennifer Goldman about her systematic review and meta-analysis on subjective cognitive complaints in Parkinson's disease, including the prevalence, epidemiology, and correlation with objective cognitive findings and neuropsychiatric disease. The article was recently named the Movement Disorders journal Review Article of the Year.

Dr. Eduardo de Pablo-Fernández interviews Dr. Iva Stankovic and Prof. Gregor Wenning on the newly published MDS Criteria for the Diagnosis of Multiple System Atrophy. Read the article.
Journal CME will be available for this article until June 17, 2023.

Dr. Farwa Ali discusses with Dr. Sara Schaefer the results of her study on the use of the MDS criteria for PSP with the MAX rules and their clinical implications, as well as the challenges of the phenotype variability of this disease in clinical practice and research. Read the article

Dr. Hilmar Sigurdsson shares the results of an FDG PET study that found 2 distinct patterns of brain metabolism related to gait disfunction in PD, suggesting that this objective measure could help better understand the neural basis of gait disorders and could also be used to predict gait involvement in clinical practice and as outcome measure in clinical trials. Read the article.

Dr. Jussi Sipilä joins Dr. Eduardo de Pablo-Fernandez to discuss the interesting findings of the article on mortality rate in Parkinson's disease using nationwide data from multiple health registries in Finland. Read the article

Dr. Marta San Luciano shares the main findings of the recently published article on the impact of non-steroidal anti-inflammatory drugs use on the risk of developing PD in a large LRRK2 mutation carriers cohort. Read the article

Dr. Brit Mollenhauer discusses the recent advances in the use of neurofilament light chain for the diagnosis and follow up of Parkinson's disease and related disorders, highlighting the results of a recent longitudinal study. Read the article

As part of the MDS Congress 2019 Special Issue, Dr. Sara Schaefer interviews Dr. Antonio Strafella about the emerging research in neuroimaging in movement disorders and plans to establish a centralized database for neuroimaging in atypical parkinsonisms.

Dr. Mcihele Matarazzo interviews Dr. David Standaert about the review article he recently published on neuroinflammation in Parkinson's disease, including the main evidence of its role on the pathogenesis of the disease and how understanding it better may help us discovering new therapeutic targets. Read the article

Dr. Hugo Morales discusses "Neuropsychiatric Features of Punding and Hobbyism in Parkinson’s Disease," by Dr. Pedro Barbosa et al., from Movement Disorders Clinical Practice. Read the article.

Studies have shown a close interplay between the cerebrovascular system and neurodegeneration. But what is the current evidence, and how can it help us better understand the pathophysiology of Lewy body disorders and potentially change their course? In this episode, Dr. Michele Matarazzo interviews Prof. Sephira Ryman about a recently published review article that explores the complexities of this relationship.
Journal CME is available until August 21, 2025 Read the article.

Dr. Kishore Kumar shares the new genes associated with Parkinson's disease, dystonia, and ataxia. He also shares how new technologies, like long read sequencing, can assist in finding epigenetic changes.

Dr. Sarah Camargos interviews Dr. Thiago Leal and Dr. Ignacio Mata about the need of genetic studies on underrepresented populations and the technical challenges they faced when alayzing admixture ancestries and X chromosome. Read the article

As part of the MDS Congress 2019 Special Issue, Dr. Matarazzo interviews Dr. Alberto Espay about technology in movement disorders, highlighting recent advances and the goal of the MDS to create a platform that will combine technology-based data and e-diaries.

Members of the task force for Axial Postural Abnormalities in Parkinsonism, Prof. Tinazzi, Dr. Geroin and Dr. Artusi, discuss new nosology and cut-off values. Read the article.

Sara Schaefer speaks to Alan Whone of the University of Bristol on his retrospective analysis of off-state dyskinesias in Parkinson's disease patients who received serial infusions of GDNF into the putamen. Read the article.

Dr. Michele Matarazzo interviews Dr. Rosa De Micco on the functional MRI correlates of anxiety in Parkinson's disease, highlighting the main results of the article she recently published on the topic in the Movement Disorders journal.Read the article

For the first episode of the special series focused on the peer review process, Dr. Daniel Di Luca speaks with Dr. Christopher Goetz about the importance and most important aspects of a peer review.

Prof. Paresh Doshi discusses with Dr. Sara Schaefer the short- and long-term outcomes of unilateral radiofrequency pallidotomy in focal and hemidystonia patients in this single-blind cohort study published in Movement Disorders Clinical Practice. Read the article

In this episode, we interviewed Prof. Jian Feng about his most recent paper covering the role of parkin mutations in human A9 dopaminergic neurons and role they play in locomotor activities of early-onset PD.
Journal CME is available until July 20, 2024 Read the article.

Dr. Sara Schaefer speaks with Dr. Nicola Pavese about the imaging modalities currently in use and emerging to differentiate parkinsonian syndromes and Parkinson's subtypes, and how imaging helps us to understand, study, and treat these conditions. Read the article

Dr. Sara Schaefer speaks with Dr. Nicola Pavese about the imaging modalities currently in use and emerging to differentiate parkinsonian syndromes and Parkinson's subtypes, and how imaging helps us to understand, study, and treat these conditions. Read the article

As part of the MDS Congress 2019 Special Issue, Dr. Matarazzo interviews Dr. K. Ray Chaudhuri about news in Parkinson’s disease and Lewy body dementia, including new treatments, scales and other advances in early and late-stage PD. Read the article

Dr. Eduardo de Pablo-Fernández speaks with Dr. Dilan Athauda about his recent paper, "The impact of type 2 diabetes in Parkinson's disease" recently published in Movement Disorders. They discuss the clinical impact of type 2 diabetes in the phenotype and disease progression and the therapeutic implications of this association. Read the article.

Dr. Sara Schaefer and Dr. Georgia Richard discuss the breakdown in medication prescribing and administration in hospitalized Parkinson's patients, and potential strategies for improvement. Read the article.

Dr. Victor Fung sat down with Dr. Michele Matarazzo at the #mdscongress to reflect on the advice from his predecessors and how that is helping him achieve his goals as MDS President.

Sara Schaefer discusses with Dr. Eduardo de Pablo-Fernandez his recent paper in Movement Disorders providing retrospective pathological validation of the 2022 MDS MSA Criteria using specimens from the Queens Square Brain Bank. Read the article.

Dr. Sara Schaefer discusses with Professor Antonio Strafella and Dr. Cecilia Peralta their work from the MDS Neuroimaging Study Group published in Movement Disorders Clinical Practice on a "Pragmatic Approach on Neuroimaging Techniques for the Differential Diagnosis of Parkinsonisms." Read the article

Benjamin Deck discusses with Dr. Schaefer the article he recently published in the Movement Disorders Clinical Practice on the patient vs. care partner assessment of cognition in Parkinson's disease. Read the article

In part 1 of the Dystonia Special Series, Dr. Francesca Morgante interviews Dr. Miryam Carecchio on pearls on diagnosis and phenomenology of dystonic syndrome.

In the last episode focused on peer reviews, Dr. Michael Okun discusses historical perspectives and future directions of the peer review process.

Dr. Michele Matarazzo speaks with Prof. Ryosuke Takahashi about the results of his recent study that shows how this anti-epileptic drug may inhibit the transmission of alpha synuclein in PD. While this was tested in animal models, future clinical trials are warranted to test the effects on PD progression. Read the article

Dr. Wszolek shares with Dr. Schaefer his extensive knowledge about the clinical, genetic, and pathological findings in Perry disease, a rare and likely underdiagnosed parkinsonian condition. Read the article.

Dr. Hugo Morales interviews Dr. Chen Honglei about his most recent paper "High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers" published in the Movement Disorders journal. Read the article.
Journal CME will be available for this article until May 20, 2023.

In this episode, Dr. Pierre-Emmanuel Sugier discusses the epidemiological associations between PD and cancers. While investigating several European GWAS databases, his group raised the conundrum whether cancer and Parkinson's disease share common risk factors. Read the article.

Dr. Michele Matarazzo interviews Prof. Roy Alcalay on the effects that the COVID-19 pandemic is having on the clinical activity and how it is changing the way we see patients. Will telemedicine be an integrating part of our clinical practice?

Dr. Marina de Koning Tijssen, the 2024 Stanley Fahn Presidential Lecture Award Winner, discusses her career history and how much she learned just by talking to patients. She also shares her views on the role of AI in the clinic and what legacy she hopes to leave for future movement disorders specialists.

Dr. Virginia Lee, the 2024 C. David Marsden Presidential Lecture Award Winner, recounts her career and what events lead her to study neurodegenerative disease. She also shares her insight into the importance of alpha synuclein research and advice for aspiring researchers.

For the sixth episode of the special series focused on the peer review process, Dr. Shweta Prasad speaks with Prof. Christine Klein to discuss the approach to reviewing a review article.

MDS President Francisco Cardoso shares with Dr. Sara Schaefer his important takeaways from his presidential term and his hopes for the future. 2023 Congress virtual access

Dr. Michele Matarazzo interviews Dr. Amy Amara, the first author of the article awarded as "2020 Research Article from Movement Disorders" on the effects of exercise on sleep in Parkinson's disease. Read the article

A recent trial showed no benefit of 1mg rasagiline versus placebo on 1-year progression in an early Parkinson's disease cohort. The investigators used a novel method to track disease progression with MRI, apart from usual clinical standards. Dr. David Vaillancourt shares the results of this trial recently published in the Movement Disorders Journal. Read the article.