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Explore every episode of the podcast Mastering Nutrition

Dive into the complete episode list for Mastering Nutrition. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

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TitlePub. DateDuration
SSRI Withdrawal Is Mitochondrial Dysfunction23 Nov 202501:29:04

Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it.

This is not medical advice, diagnosis, or treatment. 

29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression.

These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis.

On the other hand, 20-50% of people who go off experience SSRI discontinuation syndrome.

This can involve irritability, anxiety, mood problems, crying, dread, suicidal ideation, insomnia, nightmares, excessive dreaming, lethargy, fatigue, headache, tremor, sweating, anorexia, flu-like symptoms, nausea, vomiting, diarrhea, pain, numbness, tingling, feeling like something is crawling on the skin, electric shocks running through the brain or body, rushing noises, visual traces (seeing something persist when it is no longer there, or seeing moving objects leaving illusory streaks of light behind them, etc), dizziness, light-headedness, "brain zaps," vertigo, confusion, difficulty concentrating, amnesia, genital hypersensitivity, and premature ejaculation.

A closely related problem is post-SSRI sexual dysfunction (PSSD), which can cause total inability to feel the penis for males or for females the genitals and nipples, loss of sexual pleasure, weak orgasms, decreased libido, erectile dysfunction, and premature ejaculation. PSSD is often associated with general anhedonia, apathy, and poor mood.

In this video, Masterjohn maintains that the reason there are no good solutions to these problems is because we have completely misunderstood the role of serotonin and SSRIs.

Serotonin's role is to help mitochondria adapt to changing demands for oxygen-based energy production. 

SSRIs enhance some of the mechanisms, and interfere with others. They enter the cell and stimulate independent mechanisms of mitochondrial stress adaptation, but in doing so they turn a cyclical and rhythmic pathway into a constantly stimulated one, creating mitochondrial dependence and making mitochondria vulnerable to new-onset dysfunction upon withdrawal. Once they make it to the mitochondria itself, the SSRIs act as mitochondrial toxins.

Scientific references for everything covered in the video can be found in this series:

https://chrismasterjohnphd.substack.com/p/prozac-is-a-performance-enhancing

At the bottom of each article is a link to the next one.

0:30 SSRI Side Effects

1:00 SSRI Discontinuation Syndrome and PSSD

11:33 The Problem With Primary Care Doctors and Psychiatrists

14:56 The Reason We Don't Have Good Solutions Is Because We Don't Understand the Problem

16:22 Prozac Is a Performance-Enhancing Drug

18:40 Depression and Altitude

19:36 The Truth About Serotonin  

25:10 How Serotonin Helps Us Breathe 

30:05 Hypoxia Explains Why Serotonin Is So Abundant In the Gut

33:55 Serotonin, Melatonin, and the Mitochondria

35:50 Serotonin and Light

39:25 Intermittent Hypobaric Hypoxia Training

42:56 SSRIs Are Whole-Body, Primarily Non-Brain, Non-Neuronal, Mitochondrial Drugs

44:00 SSRIs and Birth Defects

46:37 SSRIs Deplete Serotonin

48:50 SSRIs Distort the Sigma-1 Receptor From a Cyclical to a Constant Activation

51:10 Different SSRIs Promote Different Ratios of Mitophagy and Mitochondrial Biogenesis

54:00 Going Off SSRIs Causes New-Onset Mitochondrial Dysfunction

58:30 Slow and Hyperbolic Tapers

1:02:10 What to Do About SSRI Withdrawal Mitochondrial Dysfunction

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondrial test Mitome.

Do You Have Hidden Mitochondrial Dysfunction?

Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don't know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.

Find it here at mito.me

How Lactate Alkalinizes Your Muscles06 Sep 202401:34:50

For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this.

You may have heard the argument against it from well-known figures like Andy Galpin, or, if you're deep into the science, you may have read the work of George Brooks.

In this lesson, we are going to cover the biochemistry of lactate production. We will see that we never make lactic acid, ever. We make lactate. Making lactate is fundamentally alkalinizing.

We will take a look at the presentation of glycolysis in the Berg and Lehninger biochemistry textbooks to see that, on the one hand, they give us everything we need to know to understand that the human body never makes lactic acid, but, on the other hand, they really do not equip us well to understand where acidity does comes from during exercise. This is because they do not consider acid-base balance important enough to completely present the proton balances of the chemical reactions.

Finally, we will cover what does cause muscular fatigue, take a look at the research on lactate supplements, and come to some conclusions about the best way to manage acidity during exercise to maximize performance.

This is part of a larger course on the biochemistry of how we derive energy from food and use it to fuel our wellness, performance, and longevity. Take the full course here:

https://chrismasterjohnphd.substack.com/p/masterclass-with-masterjohn-energy

To see the slides, watch this lesson on youtube:

https://www.youtube.com/watch?v=IrpbLllsSHQ 

To obtain the written version with timestamped slides for better studying, see here:

https://chrismasterjohnphd.substack.com/p/how-lactate-alkalinizes-your-muscles

This lesson is free for one week. After that it will be reserved for Masterpass members. You can learn more about the Masterpass here:

https://chrismasterjohnphd.substack.com/about 

You can subscribe to the Masterpass here:

https://chrismasterjohnphd.substack.com/subscribe 

2:52 How textbooks present glycolysis

3:36 What is acidity?

4:32 The acidfying and alkalinizing phases of glycolysis

7:09 Glycolysis: A brief review

10:08 The Principles

29:33 The Reactions -- and Where the Textbooks Go Wrong

38:59 Human beings do not make lactic acid

42:13 Lactate transport is even more alkalinizing to muscle

47:44 Robert Robergs Fights an Uphill Battle in Clarifying the Sources of Acidity and the Alkalinizing Effect of Lactate

1:01:08 What causes fatigue?

1:05:15 Does CO2 contribute to acidity?

1:13:45 Where is Glycolysis Getting Backed Up?

1:23:10 Conclusiuons: What's realy going on with exercise-induced acidosis.

1:26:34 Lactate supplements

1:30:53 How to use this information in training for optimal performance.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondrial test Mitome.

Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation14 Nov 202300:06:03

Watch or listen to the full critique here:

https://www.youtube.com/watch?v=kMPvCiOkEtQ

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

BH4 vs tyrosine for low neurotransmitters and a high phenylalanine-to-tyrosine ratio. | Masterjohn Q&A Files #29205 Oct 202100:19:12

Short Answer: BH4 is expensive and requires very high doses, so if the problem is modest it can much more easily be solved by taking tyrosine.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Does TMG have to be taken in the fasting state? | Masterjohn Q&A Files #29104 Oct 202100:04:00

Short Answer: While the body will tend to use TMG for methylation in the fasting state, it is normally found in food, so you should be able to absorb it with meals and hold on to it for later use, much as we do with folate.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Is urinary mycotoxin testing useful for indoor mold exposure? | Masterjohn Q&A Files #29001 Oct 202100:08:04

Short Answer: When I had a serious case of indoor mold-induced illness, I tested my urine and my apartment dust for mycotoxins. Both were high, but the classes of toxins were totally different between the two, making me think the mycotoxins in my urine came from food rather than my apartment. Symptoms going away when outside of the apartment was a far more useful clue, so I think you should consider the cost of a vacation, the cost of mycotoxins, and assume you get more information out of taking the vacation, and then decide which to do.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Ferritin sky-high without hemochromatosis? | Masterjohn Q&A Files #28930 Sep 202100:11:35

Short Answer: Even if genetics and other bloodwork don't look like hemochromatosis, sky-high ferritin justifies trying to lower it with blood donation or phlebotomy if inflammation markers are low. If this doesn't work, oxidative stress should be investigated.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Will the booster shot be worth it? | Masterjohn Q&A Files #28829 Sep 202100:14:36

Short Answer: If optimizing for efficacy, the booster shot will likely be worth it for Pfizer, whereas other vaccines don't have clear evidence of declining efficacy yet. If optimizing for safety, one should be skeptical of the booster since a 3-dose regiment hasn't been tested in clinical trials.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

How to use carbs and glycine for sleep. | Masterjohn Q&A Files #28728 Sep 202100:10:52

Short Answer: To get adequate raw material for melatonin synthesis in the brain, carbs can come any time of day and are best if high-glycemic. To suppress brain histamine levels, carbs in the evening, with low protein and relatively low fat, is best. From among protein, collagen is best at night for the glycine.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

What are the downsides to taking prescription calcitriol for bones? | Masterjohn Q&A Files #28627 Sep 202100:05:41

Short Answer: It requires more frequent dosing and has some risk of hypercalcemia, and it would be best to make sure you have adequate D and magnesium and aren't overdoing anything that could deplete D, such as other fat-soluble vitamins, first.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

NEW! Version 7 of the COVID Guide!26 Sep 202100:07:43

Newly updated September 25, 2021, and now in Version 7:

https://chris-masterjohn-phd.myshopify.com/products/the-food-and-supplement-guide-for-the-coronavirus

This guide provides my recommendations for nutritional and herbal defense against COVID. This version covers 41 randomized controlled trials, which are the gold standard of evidence, as well as many other studies providing context for interpreting the trials. Since much of this research is recent, not all of it is peer-reviewed. However, I have used my own expertise in nutritional sciences and extensive experience evaluating research to fully review the quality of this evidence myself. This protocol represents the best of science-backed strategies for nutritional and herbal anti-COVID defense.

The gold standard of evidence in medicine is the randomized, controlled trial, or RCT. In RCTs, people are randomly given a treatment, or not. That this is determined at random means people's health, behavioral traits, and choices play no role in the outcomes. This helps us be more confident the treatment really works, or doesn't work.

We now have 41 RCTs on the ability of nutrients, herbs, or other natural compounds to fight COVID. While these trials are usually small, some haven't been peer-reviewed yet, some are funded by supplement manufacturers, and most haven't yet been replicated by different researchers from different institutions and different parts of the world, they are the best evidence we currently have and serve as the highest priority evidence used in this guide.

In evaluating these trials, the most important things I looked for were whether the trials were done well, whether the data were reported clearly, and whether the interpretations were sound. However, I also considered the funding source, whether different groups had come to similar results, how much of the data was peer reviewed, and whether the substance is an essential nutrient.

Based on these considerations, I categorized anything that made the cut into three tiers: "Essentials," "Best Add-Ons," or "These Might Help." Having better quality, more trustworthy, more consistent data, and having essential nutrient status pushed the strategies up toward the Essentials tier, while lacking these qualities pushed them down toward the "These Might Help" tier. Those with intermediate support are included as Best Add-Ons.

The guide includes suggestions on how to tailor the protocol to your individual needs, your personal risk, your environmental risk, and your own risk tolerance. It also includes full instructions on how to implement the strategies.

When you buy it, you will get free updates the research continues to emerge. The guide is currently in version 7 and was last updated on September 25, 2021.

By the way, you can also get the report for free if you pre-order a copy of my Vitamins and Minerals 101 book. But if you don't want to pre-order the book, you can order it here:

https://chris-masterjohn-phd.myshopify.com/products/the-food-and-supplement-guide-for-the-coronavirus

The format of the report is a downloadable PDF. As soon as you complete your order, you will also receive an email with your download. 

The guide is 59 pages and contains 157 references.

Once again it's at chrismasterjohnphd.com/covidguide

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Does quinolinate sometimes indicate niacin or inflammation instead of B6? | Masterjohn Q&A Files #28524 Sep 202100:11:33

Short Answer: B6 cannot be ruled out, though inflammation and estrogen could also be involved. While it is possibly a regulated means of increasing excitatory effects of quinolinate, it makes sense to assume it may respond to B6.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a


Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why would 5,000 IU vitamin D cause tooth sensitivity? | Masterjohn Q&A Files #28423 Sep 202100:06:53

Short Answer: While it is unclear, it could relate to vitamin K depletion, hypercalcemia, or compensation in acid-base balance. First and foremost, use the full testing algorithm in Testing Nutritional Status: The Ultimate Cheat Sheet (available at https://chrismasterjohnphd.com/cheatsheet) rather than just testing 25(OH)D to determine deficiency.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Cancer, IV Drips, and the Glutathione Vitamin C Connection06 Nov 202300:02:10

Is high-dose vitamin C good for you?

 

High-dose intravenous vitamin C can selectively kill cancer cells in live patients and can save sepsis patients from dying, but it acts as a pro-oxidant in cancer and an antioxidant in sepsis.

 

So what does it do in the rest of us?

 

Oral doses of 2000 milligrams raise oxalate levels in most people, and as little as 400 milligrams raises oxalate in some people.

 

This seems to be the most sensitive indicator of a delicate imbalance with glutathione and other factors needed to recycle vitamin C. Such a balance actually needs to be avoided when killing cancer yet is critical to maintaining health in every other context.

 

Given that vitamin C is important to immunity and general health, how do we take advantage of these benefits without upsetting the delicate balance with glutathione and the propensity to generate oxalate?

 

That is the topic of this podcast.

 

This podcast is a preview of a video only available to Masterpass members.

 

Get evergreen access to the video and podcast, as well as the written article with references, here:

https://chrismasterjohnphd.substack.com/p/balancing-vitamin-c-and-glutathione-d6f

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

What's the best and most affordable diet for a hungry teenage boy? | Masterjohn Q&A Files #28322 Sep 202100:14:48

Short Answer: A half a gram to a gram of protein per pound of bodyweight, no more than 20-40 grams of that from protein powder, and whole foods supplying the targets for vitamins and minerals, erring on the side of overshooting them. Lentils and other legumes as primary carb foods and supply a portion of protein, and adjusting quality of meat to what you can afford, can help with budgeting.

This video was mentioned: https://chrismasterjohnphd.com/lite-videos/2018/07/24/track-vitamin-mineral-intake

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why would MCV be elevated if MMA and FIGlu are normal? | Masterjohn Q&A Files #28221 Sep 202100:06:49

Short Answer: If the cause is nutritional, FIGlu cannot rule out folate deficiency as a cause because it reflects tetrahydrofolate rather than methylene-THF. So, increasing the dose of folate or switching from methylfolate to folinic acid could be tried. Otherwise the most likely  nutritional solution would be copper.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

How to further explore slightly high coronary calcium and Lp(a) and borderline high LDL-P? | Masterjohn Q&A Files #28120 Sep 202100:13:18

Short answer: If inflammatory markers are low and Lp(a) is proportionally more elevated than LDL-P, then blood lipids probably account for part of the calcification, while factors impacting LDL oxidation come next and those impacting calcification directly come after that. For the latter two, the oxidative stress and calcium sections of the Cheat Sheet should be consulted.

Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Is blackstrap molasses toxic because of AGEs? | Masterjohn Q&A Files #28017 Sep 202100:07:42

Short answer: The science behind dietary AGEs being bad for us is very poor-quality. While food that is treated to excessively high heat, such as fried food, should not be the major portion of our diet, dietary tables of AGEs in foods are not accurate and dietary AGEs are probably not a major source of AGEs within our bodies. Blackstrap molasses should be seen as a sweetener that is better than refined sugar and can be an important source of minerals.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

If you have high ferritin, are there any downsides to blood donation? | Masterjohn Q&A Files #27714 Sep 202100:05:34

Short answer: Apart from well known acute risks such as fainting, hypoglycemia, or dehydration from a blood donation, there isn't anything to worry about except making sure you don't become deficient in iron.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

What type and how much psyllium to lower LDL-cholesterol? | Masterjohn Q&A Files #27613 Sep 202100:10:59

Short answer: 15 grams of psyllium husk should lower LDL-C over 6 weeks, and you may be able to get away with cutting the dose down to 5-10 grams if using a fine powder.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

What is the most sustainable way to implement carb cycling? | Masterjohn Q&A Files #27510 Sep 202100:14:08

Short answer: When trying to stop the early progression of insulin resistance, it is best to use a combination of strength, power and muscle building, fat loss, and high-intensity exercise in 20-second to one-minute bouts; to institute a rhythmic fasting-feeding cycle; and not to use berberine or metformin unless absolutely needed. One good way to integrate these is to use an "earn your carbs" approach to tie your carb rewards to specific physical activity goals.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Do fat and carbs differ in how much energy they yield? | Masterjohn Q&A Files #27408 Sep 202100:11:08

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Should green tea be taken with meals and can it hurt nutrient absorption? | Masterjohn Q&A Files #27307 Sep 202100:05:30

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why does methylfolate act as the off-switch for the glycine buffer system? | Masterjohn Q&A Files #27206 Sep 202100:10:19

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

How to Find the Root Cause of Autoimmunity? | Masterjohn Q&A Files #32706 Nov 202300:20:38

Question: How to Find the Root Cause of Autoimmunity?

Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism. 

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In that batch of free episodes you will also find the answer to this question:

  • Can NAC hurt your gut health?

  • Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog?

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This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

  • GLA to lower hydroxyhaemopyrrolin-2-one?

  • When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

  • Energy metabolism as a root cause of gut issues?

  • Nutrition for skin healing?

  • Nutrition for hypnic jerks?

  • Suggestions for snoring or sleep apnea?

  • Nutrition to protect against restaurant meals?

  • What is the cause of crusty eyes in the morning?

  • What causes brain fog?

  • How much oxalate should one eat each day?

  • Should I be concerned about low alkaline phosphatase?

  • What nutrients give tall children to short parents?

  • Energy metabolism impairment mimicking Wilson's disease.

  • Can taking digestive enzymes reduce our own production?

  • Rapid-fire response to non-winners from the question contest.

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 Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Vitamin D and COVID-19: The Current State of the Evidence03 Sep 202100:01:03
Here is my comprehensive review of the literature to date, covering 98 observational studies, 6 randomized controlled trials, with 173 references:   chrismasterjohnphd.com/vitamind   This is a topic we can't afford to ignore!   Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome
How to get by on poor sleep? | Masterjohn Q&A Files #27103 Sep 202100:06:24

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Across what timeframe should we diversify foods? | Masterjohn Q&A Files #27002 Sep 202100:07:45

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Nutrition For Bone Healing | Masterjohn Q&A Files #26901 Sep 202100:09:46

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

What tests to use for protein status? | Masterjohn Q&A Files #26831 Aug 202100:10:14

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Is nicotinamide riboside hydrogen malate as good as NR for fasting? | Masterjohn Q&A Files #26730 Aug 202100:17:03

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Would high-dose thiamin cause imbalances with other B vitamins? | Masterjohn Q&A Files #26627 Aug 202100:04:23

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why does B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate? | Masterjohn Q&A Files #26526 Aug 202100:17:51

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Nutrition, Metformin, and Respiratory Chain Disorders | Masterjohn Q&A Files #26425 Aug 202100:20:01

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why do some paleo advocates and functional medicine practitioners recommend low-calcium diets? | Masterjohn Q&A Files #26324 Aug 202100:16:02

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

The Powerful Duo: How Glutathione and Vitamin C IV Drips Impact Cancer01 Nov 202300:00:32

High-dose intravenous (IV) vitamin C has the potential to kill cancer cells and prolong the survival of terminal cancer patients.

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I am not a medical doctor and this is not medical advice. Please do not make cancer prevention or treatment decisions based on this information and if you make any such decisions discuss them with your physician first.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

How should you program the temperature on an Ooler or Eight Sleep? | Masterjohn Q&A Files #26223 Aug 202100:05:49

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Question: How should you program the temperature on an Ooler or Eight Sleep?

The way that I do it is, if I wake up feeling cold, I want to program it to increase the temperature at that time point so that I do not wake up cold. So, I would say, generally speaking, you want it as cold as it can be starting, that does not interfere with your sleep, and you want it as cold as can be in the middle of the night, that does not wake you up. So, I think that's going to be very different for each person, and I think whatever temperature prevents you from waking up cold, is the one you want.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Is it useful to measure HVA, VMA, and 5-HIAA? | Masterjohn Q&A Files #26120 Aug 202100:05:01

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Question: Is it useful to measure HVA, VMA, and 5-HIAA?

I find them useful in a very limited context. The limitation of their usefulness is basically that you can't really tell if something is high or low because of production or degradation.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

What nutrients require insulin to get into cells? | Masterjohn Q&A Files #26019 Aug 202100:04:52

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Question: What nutrients require insulin to get into cells?

Magnesium phosphorus and potassium are the big ones that are going to have poor uptake in response to insulin.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

What are the top whole food supplements to take? | Masterjohn Q&A Files #25918 Aug 202100:03:39

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Question: What are the top whole food supplements to take?

I mean, that's kind of too general a question, especially for end of the AMA rapid-fire. I don't make blanket supplements suggestions, but in the likes of Oystermax, an organ mix or liver supplement from Ancestral or from Paleovalley, although their organ mix is a sold out, and nutritional yeast, I think are great components of a natural, DIY, whole food multivitamin.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Could iron deficiency create a complex 1 disorder? | Masterjohn Q&A Files #25817 Aug 202100:04:15

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Question: Could iron deficiency create a complex 1 disorder?

If you're iron deficient and you have blood work that looks like a complex 1 block, and you feel like you have an energy metabolism disorder, then, while it is possible you have a genetic complex 1 deficiency, it's also possible you have an iron deficiency that is not playing out in your CBC or your thyroid panel that is impacting your energy metabolism.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Startled?! Try Glycine!28 Oct 202300:12:52

The ability to become startled is an adaptive behavior that protects us from being injured by a sudden threat, and prepares us for the fight-or-flight response when necessary.

Nevertheless, getting startled too easily can be a sign that something is wrong.

Here's what to do about it.

For the written version with links to references and links to testing, see here:

https://chrismasterjohnphd.substack.com/p/startled-try-glycine 

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

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Floxed: How to Recover From Cipro | Masterjohn Q&A Files #24904 Aug 202100:24:43

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Question: Floxed: How to Recover From Cipro

And a lot of these things probably have nothing to do with hydration, but are a direct result, or rather not direct, but a secondary indirect result of the failure of mitochondrial energy metabolism. So, I have been doing some limited research on Cipro and brainstorming some educated guesswork around recovering mitochondrial energy metabolism health. And there are multiple hypotheses around Cipro toxicity mechanisms, but the bulk of the thought is in damaging mitochondrial DNA and basically just leading to defective mitochondria. And so it seems to me like the best strategies around regaining health after Cipro toxicity, and this is all educated guesswork, none of this is tested in randomized controlled trials, and I'm not a medical doctor, and this is not medical advice, but it seems like the most promising hypotheses would be around promoting mitophagy and mitochondrial biogenesis. And so probably whatever you can do to maximize the depth of your cycling in the fast and fed states is probably the most promising thing you can do for mitochondrial turnover.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

If you correct a deficiency too fast, can you make it worse? | Masterjohn Q&A Files #24803 Aug 202100:14:14

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Question: If you correct a deficiency too fast, can you make it worse?

I think the answer is no. And I definitely don't think that happens, and I've never seen anything to suggest that happens.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

If my methionine is high, do I need to worry about betaine? | Masterjohn Q&A Files #24702 Aug 202100:03:44

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Question: If my methionine is high, do I need to worry about betaine?

If your methionine is on the higher side then it's probably the case that you don't really have an issue with recycling homocysteine to methionine. TMG's role in methylation is to support the recycling of homocysteine methionine. So if your methionine levels are on the high side of normal then you probably don't need TMG, but I'm also not sure what you mean by methylation issues.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

How do I eat to protect my joints? | Masterjohn Q&A Files #24630 Jul 202100:07:55

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Question: How do I eat to protect my joints?

From a nutritional perspective I think it's more a matter of hitting nutritional adequacy across the board. One thing that you can do that is, that's been tested is 15 grams of collagen or gelatin with a little bit of vitamin C taken a half-hour before your workouts will improve collagen synthesis in your joints. Protein and carbohydrates is one, but also sulfur is very important as a constituent of those, and manganese is very important as a cofactor for the enzymatic production of those things. It's probably not a bad idea to consume things that are in joints, and that's sort of whole foods way to do that would be to either, well, the crude way to do it is chew the joints of chickens and stuff like that.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Why do glycine and salt help with sleep? | Masterjohn Q&A Files #24529 Jul 202100:05:25

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Question: Why do glycine and salt help with sleep?

The glycine is probably working primarily by acting as an inhibitory neurotransmitter and lowering core body temperature to promote faster falling asleep and deeper sleep achieved. And then on the salt. The salt is going to stimulate antidiuretic hormone or vasopressin, which is really a mechanism to regulate the concentration of solutes in the blood, and make sure your electrolyte and fluid balance is proper. And so glycine's getting you a deeper sleep. Salt is preventing you from having to pee, and the two of those make you less likely to wake up for that purpose.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Will lowering my PTH with calcium reverse my atherosclerosis? | Masterjohn Q&A Files #24428 Jul 202100:06:37

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Question: Will lowering my PTH with calcium reverse my atherosclerosis?

And so you will definitely be removing a major source of calcification risk if you suppress your PTH down into the bottom half of the reference range. And generally, I don't know exactly where the point of maximal suppression is, and I suspect that it's different between different people.

So what I would do is, however you're approaching that with vitamin D, calcium, et cetera. Try something, re-measure it, try tweaking the dose upwards and see if it keeps going down and find the point of maximal suppression. And if you do that it's hard to say where the difference is between not getting worse and reversing.

But I think that will certainly... To the degree that you can reverse it I think that would be, definitely be an important thing to do in order to get reversal, and so I would hope so. And I think there's good reason to hope for that.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

How long does it take environment to change gene expression, epigenetics, and genetics? | Masterjohn Q&A Files #24327 Jul 202100:10:41

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Question: How long does it take environment to change gene expression, epigenetics, and genetics?

Well, generally speaking, environment mediates, I mean, it depends what you mean by environment mediating, right? So environment mediates changes in gene expression through epigenetics, but gene expression is not SNPs. SNPs are produced through mutations in the heritable genome, and then by environment changing, do you mean the production of the mutation that is the SNP for the first time? Or do you mean the change in the proportion of the population?

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome

Hormones Are Never In Charge27 Oct 202300:21:52

Hormones matter, but they are never in charge. Their abnormalities are never the root cause of anything.

All hormones do is communicate the biochemistry of one tissue to the biochemistry of another tissue.

In this episode:

  • Three Reasons For Hormones to Be Messed Up
  • Exceptions to the Rule
  • Leptin, Insulin, and Thyroid Hormone As an Example
  • How to Approach Hormones

For the written version, the links to references, and the links to testing, see here:

https://chrismasterjohnphd.substack.com/p/hormones-are-never-in-charge

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

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