Luminous: A Podcast about Psychedelics from To The Best Of Our Knowledge – Details, episodes & analysis

There’s a huge question swirling around the really big psychedelic experiences. Are these mind-blowing trips just hallucinations – the brain shot full of chemicals, playing tricks on you - or do they crack open some transpersonal dimension of consciousness? Most scholars who study psychedelics won’t go anywhere near this question, and yet it’s central to how you interpret these experiences. If you’re in psychedelic-assisted therapy, you want to know if this glimpse of the divine was real or just some figment of your imagination. Philosopher Peter Sjöstedt-Hughes believes we need a metaphysics of psychedelics to explain these powerful experiences.

Original Air Date: November 30, 2024

Interviews In This Hour:

Guests:
Peter Sjöstedt-Hughes

For more from Luminous: ttbook.org/luminous

Psychedelic people are practicing at the very edge of anyone else’s comfort zone,” says psychologist Katherine MacLean, author of the psychedelic memoir “Midnight Water.” MacLean was a pioneering psychedelic researcher at Johns Hopkins, who then left her job to pursue her own unconventional psychedelic journey. She talks with Steve Paulson about her work as a psychedelic guide, her personal history with psychoactive substances, and why she reveres the Mexican healer Maria Sabina.

Original Air Date: August 30, 2024

Guests:
Katherine MacLean

For more from Luminous: ttbook.org/luminous

Just a few years ago, it was pretty unusual to hear big-time celebrities talk about their own psychedelic experiences. But that stigma is starting to fade thanks to people like the rock star and music icon Melissa Etheridge. 

For her, this psychedelic renaissance has gotten very personal. Three years ago, her son Beckett died at the age of 21 from an opioid drug overdose. When Etheridge heard that clinical trials with psilocybin were showing real promise for treating addiction, she became an outspoken advocate for psychedelic therapy. And she started her own nonprofit organization, the Etheridge Foundation, to support scientific research into the causes and treatments for opioid addiction. 

Melissa Etheridge recently came through Madison, Wisconsin for an evening concert. Earlier that day, she stopped by the Usona Institute — which is running its own clinical trials on psilocybin and 5-MeO-DMT — where she sat down with Steve for a short interview. She talked about the death of her son, and her own life-changing experiences with ayahuasca. She explains why she’s fascinated by psychedelics as both a path for spiritual exploration and a source of creativity.

Original Air Date: July 08, 2023

For more from Luminous, check out ttbook.org/luminous.

In the last decade, an unlikely place has emerged as a hub for the latest psychedelic renaissance — Madison, Wisconsin. And the Usona Institute is a major part of that.

Usona is currently building a 93,000-square foot structure devoted to psychedelics. There’s nothing else like it. The man behind it all is the psychedelic CEO Bill Linton. He prefers to stay out of the spotlight, but he recently sat down for a rare interview with Steve Paulson.

In this episode of "Luminous," we go inside Usona’s chemistry lab and go deep with Bill Linton about his pioneering work with psychedelics.

Original Air Date: May 17, 2023

Interviews In This Hour:

The lab that could supply psilocybin to the world — Psilocybin, the 'God molecule,' and the quest to revolutionize mental health care

Guests:

Bill Linton, Alex Sherwood

Check out the full series at ttbook.org/luminous

In the first episode of "Luminous," our series about the philosophy and the future of psychedelics, how can psilocybin ease our fears about dying? And how can psychedelics change the way we approach the end of life?

Original Air Date: April 08, 2023

Interviews In This Hour:

How a pioneering psychedelic researcher 'leaned in' to his terminal cancer diagnosis — Dying without fear: How psychedelics can ease the anxiety of terminal illness — The terror and the ecstasy of psychedelics

Guests:

Roland Griffiths, Lou Lukas, Anthony Bossis

Check out the full series at ttbook.org/luminous

Are you ready for the psychedelic revolution? In the next few years, the FDA is likely to approve these mind-bending drugs for treating depression and post-traumatic stress disorder. Some states have already decriminalized psilocybin, the active ingredient in "magic" mushrooms. But for all the headlines, many questions are swirling around this psychedelic renaissance. How do we make these drugs effective, safe and accessible to the people who need the most help? And how can they be used ethically, when much of the knowledge about plant medicines comes from Indigenous cultures? 

Psychedelics also raise profound questions about the nature of consciousness and mystical experience. People often describe their psychedelic experiences as “more real” than everyday life. Is this just an illusion, or do these experiences tap into some deeper reality? 

In “Luminous,” TTBOOK executive producer Steve Paulson explores the philosophical and cultural implications of psychedelics through conversations with scientists, healers and religious scholars. You can listen to each episode on the radio or find the series plus bonus extended conversations on Apple Podcasts, Spotify, YouTube or wherever you get your podcasts.

Erik Davis’ “Blotter” is really three books in one: It’s about the way LSD tabs were embedded in blotter paper so they wouldn’t be detected by the authorities; it’s also a deep dive into the psychedelic underground; and finally, it’s an art book — gorgeously illustrated, with lots of very trippy blotter art. Steve talks with Erik about the wildness of psychedelic experiences and whether they reveal a deeper dimension of consciousness.

Original Air Date: July 20, 2024

Guests:
Erik Davis

For more from Luminous: ttbook.org/luminous

Brian Muraresku makes the controversial argument that the famous Eleusinian Mysteries were fueled by a psychedelic wine. And he speculates that this secret ceremony, with its mind-altering drugs, became the Eucharist — the foundational event of early Christianity.

Original Air Date: May 04, 2024

Guests: 

Brian Muraresku

More from Luminous: ttbook.org/luminous

It’s remarkable how fast psychedelics have gone mainstream. Just look at how so many major universities are racing to set up their own psychedelic institutes. Psilocybin and MDMA are now considered the most promising treatments for depression and PTSD that we’ve had in decades. But this is not the first time psychoactive drugs were hailed as miracle cures. Heroin and cocaine were also once considered wonder drugs. Today, what’s so striking is how the public conversation about psychedelics ignores this deeper history of intoxicants.

British historian Mike Jay wants to challenge this narrative of psychedelic “exceptionalism.” In his book “Psychonauts: Drugs and the Making of the Modern Mind,” he digs into the 19th century’s rich history of psychoactive experiences — and tells the story of seminal figures like Humphry Davy, Sigmund Freud and William James – and lots of other people I’d never heard of.

Jay is also upfront about his own psychedelic experiences. He’s had plenty of them. And he believes the scientists and doctors who study psychedelics should talk more openly about their own mind-altering experiences — which is definitely not the case for most of them.

Original Air Date: January 27, 2024

Guests:

Mike Jay

Further Reading:

"Psychonauts Drugs and the Making of the Modern Mind"—Nautilus: "Why Scientists Need to Get High"

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For all the talk about how psychedelics might transform psychiatric care, there's still a fascinating question at the heart of psychedelic science. Is it the mind-blowing experience that fundamentally changes a person’s outlook on life? Or is it the powerful molecules that rewire the brain?

Check out more from the series at ttbook.org/luminous.

Original Air Date: December 16, 2023

Interviews In This Hour:

Does psychedelic therapy need the trip? — Will psychedelics replace antidepressants? — Spiritual warriors in the psychedelic underground

Guests:

David Olson, Charles Raison, Rachel Harris

Never want to miss an episode? Subscribe to the podcast.

Want to hear more from us, including extended interviews and favorites from the archive? Subscribe to our newsletter.