Longevity Roadmap – Details, episodes & analysis

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies.

00:00 - Introduction to Longevity Roadmap

03:08 - Case Study: A 70-Year-Old Patient's Health

12:07 - Understanding Lipid Management and Atherosclerosis

19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

Hey Sapio Fans,

I’ve got something really exciting for you today—a chance to win a full-body MRI worth $2,500!

This giveaway comes from my new podcast, Longevity Junky (that’s junky with a Y). It’s a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity.

This week’s episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—before they pose a serious threat to your health.

Here’s how you can enter to win this $2,500 Prenuvo MRI scan for free:

1. Go to Apple Podcasts and find the Longevity Junky podcast (that's "Junky" with a Y).
2. Leave a five-star review for the podcast.
3. Subscribe to the podcast.
4. Take a screenshot of your review.
5. Visit LongevityJunky.com (again, "Junky" with a Y).
6. Send the screenshot of your review along with a brief explanation of why you’d like a full-body MRI.

Winners will be announced in 2 weeks—stay tuned and good luck to everyone!

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity.

00:00  The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal.

• 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life
• 0:03:33 - Average Age When Women Experience Menopause And Perimenopause
• 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In Women: Premarin And Provera
• 0:13:47 - Benefits Of Hormone Replacement Therapy
• 0:17:12 - Understanding Perimenopause And Testosterone Decline In Women
• 0:22:55 - The Secret Female Hormone: How Testosterone Replacement Can Change Your Life By Dr. Kathy C. Maupin
• 0:23:57 - Hormone Pellet Replacement For Women
• 0:25:02 - Side Effects Of Testosterone Replacement In Women
• 0:27:09 - Benefits Of Testosterone Replacement In Women
• 0:30:57 - Acoustic Wave Therapy For Women

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion. 

• 0:00:12 - Rob Hamilton’s Background 
• 0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time?
• 0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40
• 0:09:23 - Testosterone Is An Anabolic Hormone
• 0:11:17 - Testosterone Is An Important Hormone To Maintain Health. 
• 0:18:37 - Replacing Testosterone Even If You Feel Like There's Nothing Wrong With You
• 0:19:50 - Options For Increasing Testosterone Levels 
• 0:20:28 - Tongkat Ali, Ashwagandha, And Other Supplements For Increasing Testosterone Levels
• 0:27:55 - Using Clomifene To Increase Testosterone Levels 
• 0:29:20 - How Much Variability On A Day-To-Day Basis Is There In Testosterone In Men?
• 0:30:53 - Options For Testosterone Replacement 
• 0:32:03 - Topical Testosterone Application And Side Effects 
• 0:33:13 - Injectable Testosterone
• 0:35:03 - Titrating Testosterone Pellets For Optimal Therapy 
• 0:37:33 - Risks Of Testosterone Replacement Options
• 0:44:04 - Human Growth Hormones
• 0:45:59 - The Challenges Of Prescribing Human Growth Hormones
• 0:50:28 -Testosterone Is A Necessary But Not Sufficient Component Of Good Erectile Function
• 0:51:02 - Atherosclerotic Cardiovascular Disease
• 0:52:46 - Phosphodiesterase Inhibitors
• 0:51:28 - GAINSwave Shockwave Therapy
• 0:57:05 - Erectile Function And Nerve Regeneration

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics.

• 0:00:29 - What Is Psilocybin?
• 0:01:42 - The Serotonergic Effects Of Psilocybin 
• 0:04:08 - Exploring The Effects Of Microdosing Psilocybin
• 0:09:16 - Microdosing And Euphoria
• 0:12:03 - Exploring Psychedelic Microdosing
• 0:15:31 - The Fadiman Protocol
• 0:17:10 - The Stamets Protocol
• 0:19:59 - Microdosing Ketamine And Serotonergic Function 

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop.

• 0:00:39 - About Dr. Michael Mantz
• 0:02:47 - Studying With Famous Herbalists In Utah
• 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements
• 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine
• 0:08:43 - Ketamine Assisted Psychotherapy
• 0:11:06 - What Are Psychedelics?
• 0:12:49 - Understanding Ketamine's Mechanism
• 00:14:47 - Ketamine As A Dissociative Anesthetic
• 00:16:38 - Effects Of Ketamine On GABA
• 0:17:53 - Ketamine Working On The Nmda Receptors
• 0:19:44 - NMDA Receptors And Expanding Consciousness 
• 0:22:23 - Augmenting Psychotherapy With Ketamine 
• 0:28:37 - Placebo Effect And Inflection Points
• 0:33:35 - Clinical Depression And Its Symptoms
• 0:35:18 - SIG-E-CAPS And Dysregulations Of Sleep
• 0:37:24 - Is Depression Physiological Or Psychological?
• 0:39:56 - The Impact Of Depression On Perception
• 0:40:10 - Understanding Depression And Medication Options
• 0:47:39 - Effectiveness Of SSRIS In Treatment
• 0:52:38 - Ketamine Therapy And Treating Depression
• 0:54:44 - Western Medicine's Relationship With Psychedelics
• 1:01:55 - Today's Opioid Epidemic
• 1:04:26 - Psychedelics In Mental Health

Buck discusses studies on the effect of saunas for overall health and longevity.

• 0:01:35 - What's The Big Deal With Saunas?
• 0:02:03 - Kuopio Ischemic Heart Disease Study
• 0:04:44 - Sauna Benefits For The Body
• 0:04:53 - Heat Shock Proteins
• 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor
• 0:09:05 - Saunas And Longevity
• 0:11:08 - Blood Glucose Spikes While In The Sauna
• 0:12:19 - Optimal Timing For Sauna Usage

Buck and Montecito Concierge Medicine’s Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life.

• 0:00:09 - Last Pillar Of Longevity: Social Relationships
• 0:01:11 - Tribal Societies And The Common Goal Of Survival
• 0:01:29 - Human Beings Are Fundamentally Social Creatures
• 0:03:41 - Social Relationships And Physiological Determinants Of Longevity Across The Human Life Span
• 0:05:33 - Social Connectedness Is Powerful
• 0:07:47 - What Happens When You're Lacking Quality Relationships?
• 0:09:06 - How Social Relationships Have Shown Can Impact Health
• 0:11:28 - Ortisol: The Classic Stress Hormone
• 0:12:14 - Oxytocin: The Love Hormone
• 0:14:22 - Blue Zones As Parts Of The World Where People Seem To Live For A Longer Period Of Time
• 0:16:46 - Social Relationships Sustain Happiness
• 0:19:27 - Cortisol And The Obesity Epidemic
• 0:19:52 - Blue Light At Night And Cortisol Levels
• 0:20:18 - How Technology Leads To More Isolation

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies. 

• 0:01:30 What we knew about Taurine before the study.
• 0:03:22 What is Taurine?
• 0:03:39 What new information did we learn from the study?
• 0:06:30 Why do multiple models matter when it comes to studies?
• 0:07:04 What is the mechanism between improvements in health span and longevity?
• 0:07:30 Cellular Senescence - what is it and why does it matter?
• 0:09:00 DNA damage in aging.
• 0:10:30 Connecting the dots between low taurine levels and poor health.
• 0:11:10 Steps Buck is taking since reading the study.