Explore every episode of the podcast Latent Space: The AI Engineer Podcast
| Title | Pub. Date | Duration | |
|---|---|---|---|
| Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO | 22 Oct 2026 | 01:25:32 | |
Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the occasion of their monster Series D! Two y... | |||
| The Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi | 22 Oct 2026 | 00:26:40 | |
Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · Moshi · Anekha 0:00 AI Engineer New York a... | |||
| AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess | 21 Oct 2026 | 00:43:32 | |
Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes: Tenex: https://www.tenex.co/ Building an AI-nat... | |||
| The Programmable Data Center — Evan Conrad, SF Compute | 20 Oct 2026 | 00:36:43 | |
This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest Martin Casado made something so disruptive... | |||
| 🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio | 14 Oct 2026 | 01:49:56 | |
A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding, or their crazy discovery that knowing a molecule’s author is perhaps all you need... | |||
| Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics | 13 Oct 2026 | 01:11:56 | |
Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made waves by announcing Dyna-2, a world-action model pre-trained on one million hours o... | |||
| 🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub | 10 Oct 2026 | 00:31:55 | |
From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel moderated by Bra... | |||
| 🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk | 08 Oct 2026 | 01:23:59 | |
It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout: Most people are famili... | |||
| ⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0 | 02 Oct 2026 | 00:57:51 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=MWX36ZYnsm0 | |||
| Academia is for Ambition — Alex Zhang, MIT | 02 Oct 2026 | 01:41:27 | |
Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we tend to cover industry on the pod,... | |||
| Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week | 30 Sep 2026 | 00:39:12 | |
Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to learning in public and are no strangers to the... | |||
| Claude Code’s Next Era — Thariq Shihipar, Anthropic | 29 Sep 2026 | 01:32:28 | |
We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York ( https://ai.engineer/nyc/2026 ), coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive list of what Anthropic has been shipping sin... | |||
| OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha | 25 Sep 2026 | 01:20:43 | |
From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode, OpenRouter co-founder & CEO Alex ... | |||
| Runway’s WorldPrompt and the Engineering of Real-Time Worlds | 25 Sep 2026 | 01:36:20 | |
Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation.” Runway calls this an “autoregressive diffusion” model; with autoregr... | |||
| 🔬 Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics) | 23 Sep 2026 | 01:31:58 | |
The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues that cyber-warfa... | |||
| 🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science | 22 Sep 2026 | 02:01:25 | |
How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorithms, two named asteroids, and an Erdos-Bacon number of 6. This was easily the most... | |||
| Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI | 21 Sep 2026 | 02:20:52 | |
Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us! We have an unusual relationship with today’s guest: for years since coauthoring the InstructGPT paper, Diogo Almeida had been saying that API-available frontier models have ... | |||
| ⚡️ A Worm With 302 Neurons Inspired Their Architecture — Ramin Hasani, Liquid AI | 18 Sep 2026 | 01:09:51 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=V_9TCu_21SE | |||
| Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC | 16 Sep 2026 | 01:26:14 | |
AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen for an early startup behind AIUC-1, their agent standard backed by real insurance: F... | |||
| Humanity’s Last Invention — Richard Socher of Recursive | 14 Sep 2026 | 01:32:09 | |
At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from Bridgewater, Ramp, Coatue, Mastercard, Vanguard, Coinbase, Blackrock, Fidelity, P... | |||
| 🔬 “We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing | 26 Aug 2026 | 01:23:31 | |
A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Talking to experts in the field, she was met with skepticism. Weather is chaotic, physics simul... | |||
| ⏭️ Forward Deployed: Voice AI on what works in 2026 | 25 Aug 2026 | 00:36:30 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=MwNvowwcZOo | |||
| Simulation: the new Scaling Law — Joon Sung Park, Simile AI | 21 Aug 2026 | 01:09:37 | |
When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and now Simile AI’s $2B Series B, backed by GreenOaks and Index Ventures with prominent ... | |||
| ⚡️ Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research | 15 Aug 2026 | 00:47:11 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=5lFD-34dhqE | |||
| 🔬 The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery | 11 Aug 2026 | 01:35:19 | |
This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery (now worth $4B) was somehow at the heart despite being all of 2 years old. The Scienc... | |||
| The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten | 03 Aug 2026 | 01:41:28 | |
Watch the full episode on YouTube: We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become one of the new cohort of AI Infra decacorns that are (with Nvidia, Intel, and the semis com... | |||
| Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI | 28 Jul 2026 | 01:09:27 | |
There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest prize of all — if you can get the agentic interface right. A key trend we have been tracking ov... | |||
| Inside the Model Factory — Eiso Kant, Poolside AI | 23 Jul 2026 | 01:54:33 | |
In recent months, the open vs closed, and US vs China discussions on model ownership and sovereign/local AI have heated up to a fever pitch. So it is very very good news that Poolside AI are finally emerging with new models, like Laguna S 2.1, that are... | |||
| 🔬 Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist) | 21 Jul 2026 | 01:29:46 | |
Bet on information If test loss flatlines after 1.5B parameters while training loss continues to drop as you scale, that tells you that your model is limited by the amount of information in your data. Training on a single, smallish data set exposed an ... | |||
| 🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences | 16 Jul 2026 | 01:41:04 | |
Imagine a dark warehouse. Racks and racks of devices with wires, tubes, and electronics sticking out. The next AI data center? No. This is Lila Sciences ‘ dream for the future of science. A dark warehouse full of AI-guided robotics and lab equipment, c... | |||
| ⚡️ Podcast Crossover: AIE, AGI, frontier lab strategy with @matthew_berman and @swyxtv | 10 Jul 2026 | 00:28:03 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=bIOCKXcxloQ | |||
| Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO | 08 Jul 2026 | 00:57:55 | |
We’ve been running a bit of an Agent Cloud series surveying all the top inference/compute/cloud providers, from Databricks to Daytona to Railway and, even further back, E2B, but we’re excited to conclude this series returning to Modal, which has just r... | |||
| 🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI | 01 Jul 2026 | 01:48:39 | |
This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI, the company behind today’s episode. A certain introduction happened a few weeks too late and I had already happily signed at Atomwise... | |||
| ⚡️ The Blueprint for Autonomous Work Agents | Gavriel Cohen, NanoClaw | 29 Jun 2026 | 00:23:15 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=hLUGXO5DSpo | |||
| Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks | 24 Jun 2026 | 01:08:51 | |
We’re excited to have Databricks join us at AIEWF, among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in sponsor offers! Everyone is still talki... | |||
| Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan | 22 Jun 2026 | 01:06:22 | |
AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending! Thanks to the US Government issuing an export control directive on Mythos and Fable, ... | |||
| ⚡️ Every product of the future will be a living system — Ronak Malde, Trajectory.ai | 21 Jun 2026 | 00:33:58 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=DcvgPEApHT8 | |||
| The Professor of Outputmaxxing — Anjney Midha, AMP | 18 Jun 2026 | 00:59:24 | |
Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor credits and talk tracks are looking F... | |||
| 🔬 The Self-Driving Lab — Joseph Krause, Radical AI | 17 Jun 2026 | 01:16:49 | |
On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math, bio, or physics? Today we’re back in Materials S... | |||
| ⚡️ Making DeepSeek v4 outperform Opus 4.7 with Taste — @AhmadAwais , CommandCode.ai | 06 Jun 2026 | 00:40:41 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=-rIAVuaRjOg | |||
| Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs | 04 Jun 2026 | 01:15:39 | |
The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets! Most industry benchmarks compress intelligence and reasoning ability into scores. SWE-B... | |||
| 🔬 Scaling Past Informal AI - Carina Hong, Axiom Math | 03 Jun 2026 | 01:33:03 | |
In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120) and the closest AI system that repo... | |||
| ⚡️ Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build | 03 Jun 2026 | 00:38:57 | |
We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at No Priors, the leading VC AI Podcast that we also greatly admire! We ... | |||
| GitHub's plan for Agents — Kyle Daigle, GitHub | 02 Jun 2026 | 01:23:26 | |
I’m excited to work with Microsoft once again as the presenting sponsors of the AI Engineer World’s Fair! We’ll streaming live from MS Build today for a special crossover pod with our friends at No Priors and the one and only Satya Nadella. However we ... | |||
| Why Video Agent models are next — Ethan He, xAI Grok Imagine | 01 Jun 2026 | 01:43:25 | |
We’re announcing AIEWF speakers this week! Take the AI Engineering Survey! Today’s guest Ethan first joined us for the LS Paper Club as the lead on NVIDIA Cosmos World Model, but then joined xAI and built Grok Imagine in 3 months: He comes back on Late... | |||
| The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray | 28 May 2026 | 01:08:02 | |
The new AIEWF website is live! CFPs close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets! O... | |||
| 🔬 ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub | 27 May 2026 | 01:10:11 | |
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from ac... | |||
| ⚡️ Google's Open AI Strategy — Omar Sanseviero, Google DeepMind | 24 May 2026 | 00:29:59 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=Hxlayqs-IAs | |||
| ⚡️ Why you should build Science Fiction — Sunil Pai, Cloudflare | 24 May 2026 | 00:14:47 | |
Watch the full show on YouTube: https://www.youtube.com/watch?v=287Q-bs_pEU | |||
| Giving Agents Computers — Ivan Burazin, Daytona | 21 May 2026 | 01:10:27 | |
Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets! On the product side, everyone is getting Computer - Perplexity, Manus, Cursor, and so on. Meanwhile on the research side, agentic evals like TerminalBench and GDPVal are al... | |||