Kidney Compass: Navigating Clinical Trials – Details, episodes & analysis

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Kidney Compass: Navigating Clinical Trials

Health & Fitness

Frequency: 1 episode/13d. Total Eps: 11

Hosted by Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, Kidney Compass: Navigating Clinical Trials is a regular podcast exploring and breaking down the latest updates and nuances of clinical trials in nephrology. By listening to Kidney Compass, you'll get the guidance you need to navigate the changing landscape of clinical trials across the spectrum of kidney disease.

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Score global : 42%

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The PARASOL Initiative and FSGS Management, with Laura Mariani, MD, MS, and Daniel Gale, PhD, MB BChir

Wednesday, December 11, 2024 • Duration 01:04:24

In this episode of Kidney Compass: Navigating Clinical Trials, hosts Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, the director of Clinical trials in the Division of Nephrology and the vice chair of Clinical Research in the Department of Medicine at the University of Texas Medical Branch, are joined by Laura Mariani, MD, MS, co-chair of the PARASOL Initiative associate professor in the Division of Nephrology at the University of Michigan, and Daniel Gale, PhD, MB BChir, director of the UK-based RaDaR Registry and the St Peter's Chair of Nephrology at University College London.

During the episode, guests take Neuen and Wadhwani on a deep dive into the Proteinuria and GFR as Clinical Trial Endpoints in FSGS (PARASOL) Initiative. An international collaboration launched in 2023, the initiative is aimed at investigating the link between short-term changes in biomarkers, like proteinuria and GFR, and long-term outcomes to support alternative endpoints for drug approval in focal segmental glomerulosclerosis.

The video version of this episode is only available on HCPLive.com.

Chapters

00:00:00 - Start
00:02:37 - Mariani & Gale Introduction
00:05:03 - Discussing RaDaR Registry Insights
00:09:52 - Challenges and Opportunities in Rare Kidney Disease Research
00:18:44 - PARASOL Initiative Origins
00:25:45- PARASOL Partnership with US FDA
00:35:10 - Key findings from PARASOL
00:46:35 - Proteinuria as a Surrogate Outcome in FSGS
00:53:45 - Applying PARASOL Findings
01:00:30 - Future of PARASOL Initiative

Relevant disclosures for Neuen include AstraZeneca, Bayer, Boehringer and Ingelheim, Janssen, and others. Relevant disclosures for .

Kidney Compass: Navigating Clinical Trials – Details, episodes & analysis

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Kidney Compass: Navigating Clinical Trials – Details, episodes & analysis

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