Date aired: 16.03.2022

Title: A cure for MS; mindfulness debunked; and when Harry met Sally - is opposite sex friendship possible?

Papers:

• Bjornevik, K. et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science 375, 296-301, doi:10.1126/science.abj8222 (2022).
• Goldberg, S. B., Riordan, K. M., Sun, S. & Davidson, R. J. The Empirical Status of Mindfulness-Based Interventions: A Systematic Review of 44 Meta-Analyses of Randomized Controlled Trials. Perspect Psychol Sci 17, 108-130, doi:10.1177/1745691620968771 (2022).
• Szymkow, A. & Frankowska, N. Moderators of Sexual Interest in Opposite-sex Friends. Evol Psychol 20, 14747049211068672, doi:10.1177/14747049211068672 (2022).

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Date aired: 16.02.2022

Time: 17:00 -17:45

Title: Size doesn't matter, but anticipation does: Big data paradox, placebo, and perceptions of smokers

Papers:

Bradley VC, Kuriwaki S, Isakov M, et al. Unrepresentative big surveys significantly overestimated US vaccine uptake. Nature 2021;600(7890):695-700. 

Hjorth OR, Frick A, Gingnell M, et al. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial. Transl Psychiatry 2021;11(1):559. 

Philip KEJ, Bu F, Polkey MI, et al. Relationship of smoking with current and future social isolation and loneliness: 12-year follow-up of older adults in England. The Lancet Regional Health - Europe 2022;14:100302. doi

For more information click here: https://maudsleylearning.com/webinars-podcasts/kaleidoscope-live/size-doesnt-matter-but-anticipation-does-big-data-paradox-placebo-and-perceptions-of-smokers/

Title:

In this episode, the Kaleidoscope Live! team discussed:

• 95% of women report their PPE hampers their work: the dangers of being a woman in a man’s world
• The citizen scientists who took part in psychedelic micro dosing study showed improved wellbeing and life satisfaction but, half of them were on the placebo.

They covered the sex and drugs, watch the recording for the rock and roll.

Citations:

Shansky, R. M., & Murphy, A. Z. (2021). Considering sex as a biological variable will require a global shift in science culture. Nature Neuroscience, 1-8. https://doi.org/10.1038/s41593-021-00806-8

Szigeti, B, Kartner L, Blemings A et al. Self-blinding citizen science to explore psychedelic microdosing. eLife 2021; 10:e62878.

Title: Phenotyping, Relapse, and Racism

There is an impetus for the use of emerging technologies in both assessing and improving mental health, as well as in examining complex processes like recruitment practices.  In this Kaleidoscope Live! the team discuss the use of digital phenotyping for relapse in schizophrenia and the monitoring of discrimination in online recruitment.

Citations:

Henson, P, D’Mello, R, Vaidyam A et al. Anomaly detection to predict relapse risk in schizophrenia. Translational Psychiatry, 2021; 11:28. https://doi.org/10.1038/s41398-020-01123-7

Hangartner, D., Kopp, D. & Siegenthaler, M. Monitoring hiring discrimination through online recruitment platforms. Nature 589, 572–576 (2021). https://doi.org/10.1038/s41586-020-03136-0

Title: COVID and Ketamine

Citations:

• Pan K-Y, Kok AA, Eikelenboom M, Horsfall M, Jörg F, Luteijn RA, et al. The mental health impact of the COVID-19 pandemic on people with and without depressive, anxiety, or obsessive-compulsive disorders: a longitudinal study of three Dutch case-control cohorts. Lancet Psychiatry 2021. Available from: https://doi.org/10.1016/S2215-0366(20)30491-0.
• Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E. et al. Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature (2020). https://doi.org/10.1038/s41586-020-03047-0

Title: This week the Kaleidoscope team are talking about the unsung hero that is statistics, the maths that influences what we deem important in research, and an exciting emerging idea in schizophrenia.

Citations:

Gelman, A., & Vehtari, A. (2020). What are the most important statistical ideas of the past 50 years?. arXiv preprint arXiv:2012.00174 

Mealer RG, Williams SE, Daly MJ et al. Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research. Molecular Psychiatry, 2020; 25:3129-3139.

Title: In the latest episode, the Kaleidoscope crew discuss moving mental health away from being a reactive field, exploring the possibilities of prevention in school and workplaces, and reflect on environmental green and blue prescriptions for the treatment of anxiety and depression.

Citations:

• Hoare E, Callaly E, Berk M. Can Depression Be Prevented? If So, How? JAMA Psychiatry, 2020; 77(11):1095-1096.
• Tester-Jones, M., White, M.P., Elliott, L.R. et al. Results from an 18 country cross-sectional study examining experiences of nature for people with common mental health disorders. Sci Rep 10, 19408 (2020). https://doi.org/10.1038/s41598-020-75825-9

Title: Cannabis

In this episode, the Kaleidoscope team talked all things marijuana including the use of cannabidiol to treat marijuana dependence, the history and lore of the drug,  and a major flaw in the marijuana supply informing US-based research.

Citations:

• Freeman, T. P., Hindocha, C., Baio, G., Shaban, N. D., Thomas, E. M., Astbury, D., … & Bloomfield, M. A. (2020). Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial. The Lancet Psychiatry, 7(10), 865-874.
• Schwabe, A. L., Hansen, C. J., Hyslop, R. M., & McGlaughlin, M. E. (2019). Research grade marijuana supplied by the National Institute on Drug Abuse is genetically divergent from commercially available Cannabis. bioRxiv, 592725.

Date aired: 19.01.2022

Title: Courting controversy: The call for women-specific medication guidance and psychology's "physics envy" problem

Papers:

Brand BA, Haveman YRA, de Beer F, de Boer JN, Dazzan P, Sommer IEC. Antipsychotic medication for women with schizophrenia spectrum disorders. Psychol Med [Epub ahead of print] 12 Nov 2021. Available from: https://doi.org/ 10.1017/S0033291721004591.

Debrouwere S, Rosseel Y. The conceptual, cunning, and conclusive experiment in psychology. Perspect Psychol Sci [Epub ahead of print] 8 Dec 2021. Available from: https://doi.org/10.1177/17456916211026947.

Date: 01.12.2021

Title:

Good Sh*t, Bad Outcomes:

Differentiating performance from interpretation with machine learning approaches to healthcare outcomes

-AND-

The microbiome and early life indicators of mental health

Papers:

Li B, Jang I, Riphagen J et al. Identifying individuals with Alzheimer’s disease-like brains based on structural imaging in the Human Connectome Project Aging Cohort. Hum Brain Mapp, 2021; 1-12. DOI: 10.1002/hbm.25626

Ghassemi, M., Oakden-Rayner, L., & Beam, A. L. (2021). The false hope of current approaches to explainable artificial intelligence in health care. The Lancet Digital Health, 3(11), e745-e750.

Laue, HE, Karagas, MR, Coker, MO et al. Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes. Pediatric Research, 2021; DOI: 10.1038/s41390-021-01785-z

Register for future episodes:

https://us02web.zoom.us/webinar/register/WN_jgj-1_9eSe-K8_HcBGihFQ

In this Kaleidoscope Live episode, the team discuss:

Real life decisions: nudge or hold? Antidepressant withdrawal and behaviour modification

Lewis G, Marston L, Duffy L et al. Maintenance or discontinuation of antidepressants in primary care. The New England Journal of Medicine, 2021; 385(14): 1257-1267. DOI: 10.1056/NEJMoa2106356

Dai, H. et al (2021) Behavioural nudges increase COVID-19 vaccinations. Nature, Vol 597, September, pp. 404–409

Watch on YouTube here:

https://youtu.be/z9uASO70fbM 

Papers:

1. Stop that! It’s not Tourette’s but a new type of mass sociogenic illness
2. Grey and white matter microstructure is associated with polygenic risk for schizophrenia

Read more here:

https://maudsleylearning.com/webinars-podcasts/kaleidoscope-live/big-ass-data-brain-correlation-and-social-contagion/ 

Citations:

Arantes, J., Pinho, M., Wearden, J., & Albuquerque, P. B. (2021). “Time Slows Down Whenever You Are Around” for Women but Not for Men. Frontiers in Psychology, 12, 951. https://www.frontiersin.org/article/10.3389/fpsyg.2021.641729

K. Schmack, M. Bosc, T. Ott, J. F. Sturgill, A. Kepecs. Striatal dopamine mediates hallucination-like perception in mice. Science, 2021; 372 (6537): eabf4740 DOI: 10.1126/science.abf4740

Title: In this episode the panelists indulged in the positives of hedonism and took controversy head on discussing a now retracted paper on professionalism – sexism in a scientific sheep’s clothing?

Citations:

• Bernecker K, Becker D. Beyond self-control: mechanisms of hedonic goal
  pursuit and its relevance for well-being. Pers Soc Psychol Bull 26 Jul 2020 [Epub
  ahead of print]. Available from: https://doi.org/10.1177/0146167220941998.
• Hardouin S, Cheng TW, Mitchell E, Raulli SJ, Jones DW, Siracuse JJ, et al.
  RETRACTED: Prevalence of unprofessional social media content among young
  vascular surgeons. J Vasc Surg 2020; 72: 667–71.

Title: The role of media in suicide, a statistical controversy with fMRI data, and the perceived helpfulness of treatment.

Citations:

• Harris, M. G., Kazdin, A. E., Chiu, W. T., Sampson, N. A., Aguilar-Gaxiola, S., Al-Hamzawi, A., … & Cía, A. (2020). Findings From World Mental Health Surveys of the Perceived Helpfulness of Treatment for Patients With Major Depressive Disorder. JAMA Psychiatry.
• Niederkrotenthaler, T., Braun, M., Pirkis, J., Till, B., Stack, S., Sinyor, M., … & Scherr, S. (2020). Association between suicide reporting in the media and suicide: systematic review and meta-analysis. Bmj, 368.
• Botvinik-Nezer, R., Holzmeister, F., Camerer, C. F., Dreber, A., Huber, J., Johannesson, M., … & Avesani, P. (2020). Variability in the analysis of a single neuroimaging dataset by many teams. Nature, 1-7.
• Berg, E. L., Pedersen, L. R., Pride, M. C., Petkova, S. P., Patten, K. T., Valenzuela, A. E., … & Silverman, J. L. (2020). Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats. Translational psychiatry, 10(1), 1-16.

Title: Size doesn’t matter – either in psychometrics or brain volume

Citations:

• Lutz W, Striessnig W, Dimitrova A et al. Years of good life is a well-being indicator designed to serve research on sustainability. Proceedings of the National Academy of Sciences, 2021; 118 (12): e1907351118 DOI: 10.1073/pnas.1907351118
• Chopra S, Fornito A, Francey SM et al. Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study. Neuropsychopharmacology, 2021, https://doi.org/10.1038/s41386-021-00980-0