Explore every episode of the podcast Immune
| Title | Pub. Date | Duration | |
|---|---|---|---|
| Immune 83: Immune cells eating other cells | 27 Aug 2024 | 01:23:37 | |
Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Music by Steve Neal. | |||
| Immune Booster #7: Emerging viruses with David Martinez | 20 Aug 2024 | 00:23:46 | |
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey. Hosts: Cindy Leifer and Steph Langel Guest: David Martinez Subscribe (free): Apple Podcasts, RSS, email Music by Tatami. Content in this podcast should not be construed as medical advice. | |||
| Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes | 28 May 2024 | 01:15:56 | |
Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Music by Steve Neal. | |||
| Immune 79: Spa therapy for the immune system | 26 May 2024 | 01:04:21 | |
Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 78: Tolerance and tolerating many vaccines | 26 Mar 2024 | 01:24:03 | |
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 77: Squeezing the most killing out of neutrophils | 27 Feb 2024 | 00:56:58 | |
Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 76: Macrophages to the rescue with Juliet Morrison | 30 Jan 2024 | 01:07:07 | |
Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Guest: Juliet Morrison Click arrow to play
Music by Steve Neal | |||
| Immune 75: Ang Cui unveils the cytokine symphony | 28 Dec 2023 | 01:15:03 | |
Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 74: Germinal center dynamics with Carla Nowosad | 11 Dec 2023 | 01:11:19 | |
Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Carla R. Nowosad Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 73: Big macs | 08 Nov 2023 | 01:14:32 | |
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 72: After dark in the library with Ellen Rothenberg | 23 Sep 2023 | 00:57:29 | |
From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Ellen Rothenberg Click arrow to play
Music by Steve Neal. | |||
| Immune 71: Can parasitic worms prevent pandemics? | 08 Sep 2023 | 01:13:33 | |
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune Booster #6: From Ghana to heat shock with Robert Binder | 13 Aug 2024 | 00:27:29 | |
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science. Hosts: Cindy Leifer and Brianne Barker Guest: Robert Binder Subscribe (free): Apple Podcasts, RSS, email Music by Tatami. Content in this podcast should not be construed as medical advice. | |||
| Immune 70: Immunology of picky eating | 26 Jul 2023 | 01:07:32 | |
Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 69: Lung cancer and retroviruses | 15 Jun 2023 | 01:09:50 | |
Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Kevin Ng Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 68: Sins and blessings of immunity | 18 May 2023 | 01:07:42 | |
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Links for this episode
Music by Steve Neal. Send your immunology questions and comments to immune@microbe.tv | |||
| Immune 67: Can T cells live forever? | 03 May 2023 | 01:15:32 | |
Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 66: COVID-19 immune memory - what you need to know | 04 Apr 2023 | 01:30:07 | |
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 65: Infection infidelities with Jonathan Kagan | 20 Feb 2023 | 01:15:40 | |
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Jonathan C. Kagan Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 64: A tangled web of wires | 24 Jan 2023 | 01:50:11 | |
Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal | |||
| Immune 63: Immune, promptly | 20 Dec 2022 | 01:42:59 | |
Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 62: Every cell is an immune cell with De'Broski Herbert | 02 Dec 2022 | 01:23:43 | |
De'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests D'Broski Herbert Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga | 08 Nov 2022 | 01:04:23 | |
From SLB22 on the Island of Hawai'i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests: Julia Bohannon and Musa Mhlanga Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune Booster #5: Infections and the gut microbiome with Rafael Polidoro | 06 Aug 2024 | 00:28:35 | |
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts: Cindy Leifer and Steph Langel Guest: Rafael Polidoro Subscribe (free): Apple Podcasts, RSS, email Music by Tatami. Content in this podcast should not be construed as medical advice. | |||
| Immune 60: Immunoeducation with Sumali Pandey and Phil Mixter | 22 Sep 2022 | 01:41:50 | |
Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 59: Forks in the road: Th17 cells with Mandy McGeachy | 19 Aug 2022 | 01:23:00 | |
At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be 'good' or 'bad' in their function. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Mandy McGeachy Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 58: Gut B cells awry in ulcerative colitis | 03 Aug 2022 | 01:17:22 | |
Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 57: Bacteria, the new cure for wounds? | 30 Jun 2022 | 01:27:40 | |
Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 56: Flip flops on the thymic beach with Al Singer | 01 Jun 2022 | 01:15:00 | |
Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Al Singer Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 55: Cells that suck at their job | 03 May 2022 | 01:09:17 | |
Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 54: Asthma and aging | 06 Apr 2022 | 01:28:04 | |
Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 53: Dendritic cell robbers | 21 Feb 2022 | 01:20:25 | |
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 52: B cell boot camp with Gabriel Victora | 29 Jan 2022 | 01:13:33 | |
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Gabriel Victora Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 51: Teenage NINJA mice with Nikhil Joshi | 22 Dec 2021 | 01:03:23 | |
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Nikhil Joshi Subscribe (free): iTunes, Google Podcasts. RSS, email Music by Steve Neal. | |||
| Immune 82: Bat antibodies are hot | 30 Jul 2024 | 01:14:58 | |
Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel and Brianne BarkerSubscribe (free): Apple Podcasts, RSS, email
Music by Steve Neal. | |||
| Immune 50: Red blood cells are immune sentinels | 11 Nov 2021 | 01:21:25 | |
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 49: I fell in love with worms with Keke Fairfax | 13 Oct 2021 | 01:34:20 | |
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 48: Environmental enteric dysfunction with Timothy Hand | 13 Sep 2021 | 01:14:56 | |
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Timothy Hand Click arrow to play
Music by Steve Neal. | |||
| Immune 47: Trapping viruses in NETs | 23 Aug 2021 | 01:10:51 | |
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 46: Bats don't STING like a bee | 27 Jul 2021 | 01:10:37 | |
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 45: Immune messages | 16 Jun 2021 | 01:23:52 | |
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 44: Got IgA on the brain | 17 May 2021 | 01:12:12 | |
On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box | 24 Mar 2021 | 01:18:53 | |
On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal.
| |||
| Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler | 13 Feb 2021 | 01:11:23 | |
Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Christian Gaebler Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 41: Zebrafish immunology with Madina Wane | 25 Jan 2021 | 01:23:00 | |
Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Madina Wane Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune Booster #4: Human autoimmunity with Jane Buckner | 23 Jul 2024 | 00:19:51 | |
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer and Steph Langel Guest: Jane Buckner Subscribe (free): Apple Podcasts, RSS, email Music by Tatami. Content in this podcast should not be construed as medical advice. | |||
| Immune 40: COVID-19 nuances | 30 Dec 2020 | 01:35:18 | |
Immune reminisces about a year in COVID-19 immunology, Steph's receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 39: A Tonka Truck full of salt | 01 Dec 2020 | 01:23:38 | |
Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 38: COVID-19 and kids with Sallie Permar | 28 Nov 2020 | 01:10:57 | |
Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne BarkerGuest: Sallie Permar Subscribe (free): iTunes, Google Podcasts. RSS, email
Music by Steve Neal. | |||
| Immune 37: Black in Immuno | 16 Nov 2020 | 02:00:55 | |
Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean Become a patron of Immune! Links for this episode
Music by Steve Neal. | |||